SIMILAR PATTERNS OF AMINO ACIDS FOR 1DMA_A_NCAA700_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
4 HIS A 412
GLY A 411
LEU A 406
TYR A 410
None
0.72A 1dmaA-1aorA:
undetectable
1dmaA-1aorA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avg TRIABIN

(Meccus
pallidipennis)
PF03973
(Triabin)
4 GLY I  30
TYR I  58
LEU I  27
ALA I  28
None
0.84A 1dmaA-1avgI:
undetectable
1dmaA-1avgI:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta)
PF02763
(Diphtheria_C)
5 HIS A  21
GLY A  22
ALA A  62
TYR A  65
GLU A 148
APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.7A)
APU  A 200 ( 3.6A)
None
0.61A 1dmaA-1dtpA:
9.7
1dmaA-1dtpA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta)
PF02763
(Diphtheria_C)
5 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
0.46A 1dmaA-1dtpA:
9.7
1dmaA-1dtpA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efy POLY (ADP-RIBOSE)
POLYMERASE


(Gallus gallus)
PF00644
(PARP)
PF02877
(PARP_reg)
5 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.51A 1dmaA-1efyA:
5.8
1dmaA-1efyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epv ALANINE RACEMASE

(Geobacillus
stearothermophilus)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 HIS A  45
GLY A  44
ALA A  42
TYR A  43
None
None
None
DCS  A1001 (-4.3A)
0.87A 1dmaA-1epvA:
undetectable
1dmaA-1epvA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE


(Escherichia
coli)
PF13378
(MR_MLE_C)
4 GLY A  41
TYR A  31
ALA A  90
GLU A  44
None
0.81A 1dmaA-1fhuA:
undetectable
1dmaA-1fhuA:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa)
PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target)
6 HIS A 440
GLY A 441
TYR A 470
LEU A 477
ALA A 478
TYR A 481
None
0.29A 1dmaA-1ikpA:
33.1
1dmaA-1ikpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa)
PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target)
5 TYR A 470
LEU A 477
ALA A 478
TYR A 481
GLU A 553
None
0.65A 1dmaA-1ikpA:
33.1
1dmaA-1ikpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE


(Escherichia
coli)
PF01380
(SIS)
5 GLY A 471
TYR A 497
LEU A 480
ALA A 479
TYR A 476
None
1.02A 1dmaA-1morA:
undetectable
1dmaA-1morA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT


(Acidaminococcus
fermentans)
PF01039
(Carboxyl_trans)
4 GLY A 378
TYR A 371
ALA A 377
GLU A 373
None
0.75A 1dmaA-1pixA:
undetectable
1dmaA-1pixA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc6 HYPOTHETICAL PROTEIN
YLBA


(Escherichia
coli)
PF05899
(Cupin_3)
PF07883
(Cupin_2)
4 GLY A1106
LEU A1154
ALA A1151
TYR A1108
None
0.91A 1dmaA-1rc6A:
undetectable
1dmaA-1rc6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa)
PF01370
(Epimerase)
4 HIS A  53
GLY A  52
ALA A  25
GLU A  59
None
NAD  A 342 (-2.9A)
NAD  A 342 (-4.2A)
None
0.81A 1dmaA-1sb8A:
undetectable
1dmaA-1sb8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 HIS A  44
GLY A  43
ALA A  41
TYR A  42
None
None
None
DCS  A 401 (-4.6A)
0.83A 1dmaA-1vftA:
undetectable
1dmaA-1vftA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG


(Thermus
thermophilus)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II)
4 GLY A 481
LEU A 550
ALA A 551
TYR A 470
None
0.85A 1dmaA-1wdtA:
undetectable
1dmaA-1wdtA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5d PROTEIN
DISULFIDE-ISOMERASE
A6


(Homo sapiens)
PF00085
(Thioredoxin)
4 GLY A  80
LEU A  75
ALA A  76
TYR A  79
None
0.91A 1dmaA-1x5dA:
undetectable
1dmaA-1x5dA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli)
PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C)
4 GLY A 612
TYR A 398
TYR A 613
GLU A 434
None
UGA  A1101 (-4.5A)
None
UGA  A1101 (-4.0A)
0.73A 1dmaA-1z7eA:
undetectable
1dmaA-1z7eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl5 MGC83862 PROTEIN

(Xenopus laevis)
PF00013
(KH_1)
4 GLY A  27
LEU A  33
ALA A  30
GLU A  36
None
0.85A 1dmaA-2bl5A:
undetectable
1dmaA-2bl5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0n A197

(Sulfolobus
turreted
icosahedral
virus 1)
no annotation 4 GLY A 149
ALA A 138
TYR A 153
GLU A  42
None
0.88A 1dmaA-2c0nA:
undetectable
1dmaA-2c0nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN


(Mus musculus)
PF04564
(U-box)
PF12895
(ANAPC3)
4 LEU A  90
ALA A  61
TYR A  64
GLU A  89
None
0.83A 1dmaA-2c2lA:
undetectable
1dmaA-2c2lA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE


(Escherichia
coli)
PF01380
(SIS)
PF13522
(GATase_6)
4 GLY A 471
LEU A 480
ALA A 479
TYR A 476
None
0.84A 1dmaA-2j6hA:
undetectable
1dmaA-2j6hA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nw0 PLYB

(unidentified
phage)
PF01183
(Glyco_hydro_25)
4 TYR A 121
ALA A  59
TYR A  58
GLU A  92
ACT  A1020 (-3.8A)
None
ACT  A1020 ( 3.9A)
ACT  A1020 (-3.8A)
0.87A 1dmaA-2nw0A:
undetectable
1dmaA-2nw0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odo ALANINE RACEMASE

(Pseudomonas
fluorescens)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 HIS A  39
GLY A  38
ALA A  36
TYR A  37
None
None
None
LLP  A  33 ( 4.5A)
0.88A 1dmaA-2odoA:
undetectable
1dmaA-2odoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqf POLY [ADP-RIBOSE]
POLYMERASE 12


(Homo sapiens)
PF00644
(PARP)
4 HIS A 564
GLY A 565
TYR A 596
TYR A 607
GAB  A 701 ( 3.7A)
GAB  A 701 (-3.6A)
GAB  A 701 (-4.5A)
GAB  A 701 (-3.3A)
0.24A 1dmaA-2pqfA:
5.3
1dmaA-2pqfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLY A  46
TYR A  35
ALA A 108
GLU A  49
None
0.77A 1dmaA-2qddA:
undetectable
1dmaA-2qddA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 HIS A  47
GLY A  46
ALA A  44
TYR A  45
None
None
None
IN5  A1394 ( 4.4A)
0.88A 1dmaA-2vd9A:
undetectable
1dmaA-2vd9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum)
PF03417
(AAT)
4 GLY A 102
LEU A 169
ALA A 168
GLU A 258
None
0.77A 1dmaA-2x1cA:
undetectable
1dmaA-2x1cA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE


(Pseudomonas sp.
P-501)
no annotation 4 GLY A  67
TYR A  73
LEU A 669
ALA A 668
FAD  A 801 (-3.4A)
None
None
None
0.73A 1dmaA-2yr5A:
undetectable
1dmaA-2yr5A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE


(Streptococcus
agalactiae)
PF07470
(Glyco_hydro_88)
4 GLY A 371
ALA A  55
TYR A 364
GLU A  68
None
0.88A 1dmaA-2zzrA:
undetectable
1dmaA-2zzrA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b78 EXOTOXIN A

(Pseudomonas
aeruginosa)
PF09009
(Exotox-A_cataly)
7 HIS B 440
GLY B 441
TYR B 470
LEU B 477
ALA B 478
TYR B 481
GLU B 553
NAD  B 700 (-3.9A)
NAD  B 700 (-3.9A)
NAD  B 700 (-3.9A)
NAD  B 700 ( 4.8A)
NAD  B 700 (-3.6A)
NAD  B 700 (-3.4A)
NAD  B 700 (-3.5A)
0.34A 1dmaA-3b78B:
33.1
1dmaA-3b78B:
99.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3


(Homo sapiens)
PF00644
(PARP)
PF02877
(PARP_reg)
4 HIS A 384
GLY A 385
TYR A 414
TYR A 425
KU8  A 601 (-4.0A)
KU8  A 601 (-3.5A)
KU8  A 601 (-4.1A)
KU8  A 601 (-3.5A)
0.37A 1dmaA-3c49A:
5.9
1dmaA-3c49A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3


(Homo sapiens)
PF00644
(PARP)
PF02877
(PARP_reg)
4 HIS A 384
TYR A 414
TYR A 425
GLU A 514
KU8  A 601 (-4.0A)
KU8  A 601 (-4.1A)
KU8  A 601 (-3.5A)
KU8  A 601 (-3.9A)
0.66A 1dmaA-3c49A:
5.9
1dmaA-3c49A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE


(Escherichia
coli)
PF02798
(GST_N)
PF13410
(GST_C_2)
4 GLY A 222
TYR A 225
LEU A 231
ALA A 228
None
0.78A 1dmaA-3c8eA:
undetectable
1dmaA-3c8eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cea MYO-INOSITOL
2-DEHYDROGENASE


(Lactobacillus
plantarum)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 GLY A  14
TYR A  62
LEU A  41
ALA A  40
NAD  A 400 (-3.3A)
None
NAD  A 400 (-4.2A)
NAD  A 400 (-3.6A)
0.91A 1dmaA-3ceaA:
undetectable
1dmaA-3ceaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc2 O-SUCCINYLBENZOATE
SYNTHASE


(Salmonella
enterica)
PF13378
(MR_MLE_C)
4 GLY A  41
TYR A  31
ALA A  90
GLU A  44
SIN  A 401 ( 4.7A)
None
None
None
0.78A 1dmaA-3gc2A:
undetectable
1dmaA-3gc2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7v O-SUCCINYLBENZOATE
SYNTHASE


(Thermosynechococcus
elongatus)
PF13378
(MR_MLE_C)
4 GLY A  41
TYR A  30
ALA A  92
GLU A  44
None
0.80A 1dmaA-3h7vA:
undetectable
1dmaA-3h7vA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkv POLY [ADP-RIBOSE]
POLYMERASE 10


(Homo sapiens)
PF00644
(PARP)
5 HIS A 887
GLY A 888
TYR A 919
LEU A 926
TYR A 932
3AB  A1025 (-3.8A)
3AB  A1025 (-3.5A)
3AB  A1025 (-4.4A)
3AB  A1025 (-4.4A)
3AB  A1025 (-3.7A)
0.33A 1dmaA-3hkvA:
5.5
1dmaA-3hkvA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25


(Bacillus
anthracis)
PF01183
(Glyco_hydro_25)
4 TYR A 124
ALA A  62
TYR A  61
GLU A  95
MES  A 400 (-3.6A)
None
MES  A 400 (-4.0A)
MES  A 400 (-3.5A)
0.76A 1dmaA-3hmcA:
undetectable
1dmaA-3hmcA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jup PHENAZINE
BIOSYNTHESIS PROTEIN
A/B


(Burkholderia
lata)
PF03284
(PHZA_PHZB)
4 HIS A  42
GLY A  71
LEU A  78
ALA A  74
None
0.87A 1dmaA-3jupA:
undetectable
1dmaA-3jupA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ki6 CHOLIX TOXIN

(Vibrio cholerae)
PF09009
(Exotox-A_cataly)
6 HIS A 460
GLY A 461
TYR A 493
ALA A 501
TYR A 504
GLU A 581
G9L  A   1 (-3.9A)
G9L  A   1 (-3.7A)
G9L  A   1 (-4.5A)
G9L  A   1 (-3.4A)
G9L  A   1 (-3.5A)
G9L  A   1 (-4.6A)
0.27A 1dmaA-3ki6A:
25.3
1dmaA-3ki6A:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE


(Klebsiella
pneumoniae)
PF00266
(Aminotran_5)
4 GLY A 335
LEU A 341
ALA A 338
GLU A 344
None
0.82A 1dmaA-3nnkA:
undetectable
1dmaA-3nnkA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae)
PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target)
6 HIS A 460
GLY A 461
TYR A 493
ALA A 501
TYR A 504
GLU A 581
NAD  A 700 (-3.8A)
NAD  A 700 (-3.7A)
NAD  A 700 ( 3.7A)
NAD  A 700 (-3.5A)
NAD  A 700 (-3.4A)
NAD  A 700 (-3.2A)
0.36A 1dmaA-3q9oA:
24.9
1dmaA-3q9oA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb9 DNA POLYMERASE III
SUBUNIT BETA


(Mycobacterium
tuberculosis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
4 GLY A 304
ALA A 302
TYR A 326
GLU A 329
None
0.90A 1dmaA-3rb9A:
undetectable
1dmaA-3rb9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides)
PF01370
(Epimerase)
4 HIS A  53
GLY A  52
ALA A  25
GLU A  59
None
NAD  A 343 (-3.0A)
NAD  A 343 (-4.3A)
None
0.74A 1dmaA-3rucA:
undetectable
1dmaA-3rucA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s46 ALANINE RACEMASE

(Streptococcus
pneumoniae)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 HIS A  46
GLY A  45
ALA A  43
TYR A  44
None
None
None
LLP  A  40 ( 4.6A)
0.92A 1dmaA-3s46A:
undetectable
1dmaA-3s46A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 GLY A  34
LEU A 117
ALA A 118
TYR A 121
None
0.73A 1dmaA-3tqpA:
undetectable
1dmaA-3tqpA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 GLY A 360
ALA A 333
TYR A 359
GLU A 304
None
0.82A 1dmaA-3tqpA:
undetectable
1dmaA-3tqpA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLY A   9
TYR A  15
ALA A 142
GLU A 327
FAD  A 500 (-3.2A)
None
FAD  A 500 (-4.8A)
None
0.87A 1dmaA-3urhA:
undetectable
1dmaA-3urhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B


(Enterococcus
hirae)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
4 HIS D 242
GLY D 296
LEU D 235
ALA D 236
None
0.85A 1dmaA-3vr5D:
undetectable
1dmaA-3vr5D:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1


(Sulfolobus
solfataricus)
PF10040
(CRISPR_Cas6)
4 LEU A 258
ALA A 259
TYR A 262
GLU A 127
None
0.75A 1dmaA-3zfvA:
undetectable
1dmaA-3zfvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a39 METALLO-CARBOXYPEPTI
DASE


(Pseudomonas
aeruginosa)
PF00246
(Peptidase_M14)
4 HIS A  40
GLY A  10
ALA A   5
GLU A  44
None
0.75A 1dmaA-4a39A:
undetectable
1dmaA-4a39A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae)
PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T)
5 HIS A  21
GLY A  22
TYR A  54
ALA A  62
TYR A  65
None
0.63A 1dmaA-4ae0A:
9.7
1dmaA-4ae0A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae)
PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T)
4 TYR A  54
ALA A  62
TYR A  65
GLU A 148
None
0.79A 1dmaA-4ae0A:
9.7
1dmaA-4ae0A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bk1 PROBABLE SALICYLATE
MONOOXYGENASE


(Rhodococcus
jostii)
PF01494
(FAD_binding_3)
4 HIS A  53
GLY A  51
LEU A  58
ALA A  55
None
0.85A 1dmaA-4bk1A:
undetectable
1dmaA-4bk1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT


(Salmonella
enterica)
PF00374
(NiFeSe_Hases)
4 GLY A 305
LEU A 302
ALA A 303
TYR A 304
None
0.88A 1dmaA-4c3oA:
undetectable
1dmaA-4c3oA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccl 50S RIBOSOMAL
PROTEIN L16 ARGININE
HYDROXYLASE


(Escherichia
coli)
PF08007
(Cupin_4)
4 GLY A 120
LEU A 192
ALA A 191
TYR A 190
None
0.77A 1dmaA-4cclA:
undetectable
1dmaA-4cclA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 HIS A  80
GLY A  79
ALA A  77
TYR A  78
None
None
None
LLP  A  74 ( 4.4A)
0.87A 1dmaA-4dzaA:
undetectable
1dmaA-4dzaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE


(Pectobacterium
carotovorum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 380
ALA A 381
TYR A 384
GLU A 351
None
0.58A 1dmaA-4e4fA:
undetectable
1dmaA-4e4fA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48


(Caldicellulosiruptor
bescii)
PF02011
(Glyco_hydro_48)
4 GLY A 289
LEU A 133
TYR A 290
GLU A 136
None
0.93A 1dmaA-4el8A:
undetectable
1dmaA-4el8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL


(Rhodopseudomonas
palustris)
PF13458
(Peripla_BP_6)
4 GLY A 309
LEU A  56
ALA A  53
TYR A 310
None
None
None
EDO  A 402 (-4.5A)
0.81A 1dmaA-4eygA:
undetectable
1dmaA-4eygA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0d POLY [ADP-RIBOSE]
POLYMERASE 16


(Homo sapiens)
PF00644
(PARP)
6 HIS A 152
GLY A 153
TYR A 182
LEU A 189
ALA A 190
TYR A 193
3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 ( 4.7A)
3AB  A 301 (-3.9A)
3AB  A 301 (-3.8A)
0.37A 1dmaA-4f0dA:
4.7
1dmaA-4f0dA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0e POLY [ADP-RIBOSE]
POLYMERASE 15


(Homo sapiens)
PF00644
(PARP)
4 HIS A 537
GLY A 538
TYR A 569
TYR A 582
0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
0RU  A 701 (-3.7A)
0.30A 1dmaA-4f0eA:
5.1
1dmaA-4f0eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ff5 GLYCOSYL HYDROLASE
25


(Streptococcus
pneumoniae)
PF01183
(Glyco_hydro_25)
4 TYR A 162
ALA A  99
TYR A  98
GLU A 133
None
0.81A 1dmaA-4ff5A:
undetectable
1dmaA-4ff5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Dickeya
paradisiaca)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 391
ALA A 392
TYR A 395
GLU A 362
None
0.66A 1dmaA-4ihcA:
undetectable
1dmaA-4ihcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11


(Homo sapiens)
PF00017
(SH2)
4 GLY A 119
LEU A 125
ALA A 122
GLU A 128
None
0.90A 1dmaA-4jegA:
undetectable
1dmaA-4jegA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2k TANKYRASE-2

(Homo sapiens)
PF00644
(PARP)
4 HIS A1031
GLY A1032
TYR A1060
TYR A1071
1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.3A)
0.21A 1dmaA-4l2kA:
2.8
1dmaA-4l2kA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 HIS A  45
GLY A  44
ALA A  42
TYR A  43
None
None
None
DCS  A 401 (-4.6A)
0.90A 1dmaA-4lutA:
undetectable
1dmaA-4lutA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnm CHITINASE A

(Cycas revoluta)
PF00704
(Glyco_hydro_18)
4 GLY A 110
TYR A  32
LEU A 105
TYR A 109
None
0.87A 1dmaA-4mnmA:
undetectable
1dmaA-4mnmA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN


(Bordetella
pertussis)
PF13458
(Peripla_BP_6)
4 GLY A 304
LEU A  29
ALA A  26
TYR A 305
None
0.87A 1dmaA-4mptA:
undetectable
1dmaA-4mptA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN


(Thermomonospora
curvata)
PF13458
(Peripla_BP_6)
4 GLY A 332
LEU A  77
ALA A  74
TYR A 333
None
0.83A 1dmaA-4n03A:
undetectable
1dmaA-4n03A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oa7 TANKYRASE-1

(Homo sapiens)
PF00644
(PARP)
5 HIS A1184
GLY A1185
TYR A1213
TYR A1224
GLU A1291
2XS  A1402 (-4.2A)
None
2XS  A1402 (-4.2A)
2XS  A1402 ( 3.9A)
None
0.61A 1dmaA-4oa7A:
6.0
1dmaA-4oa7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqa POLY [ADP-RIBOSE]
POLYMERASE 1


(Homo sapiens)
PF00644
(PARP)
PF02877
(PARP_reg)
PF05406
(WGR)
5 HIS C 862
GLY C 863
TYR C 896
TYR C 907
GLU C 988
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
0.52A 1dmaA-4oqaC:
5.4
1dmaA-4oqaC:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pua GLUTATHIONE
S-TRANSFERASE


(Streptococcus
pneumoniae)
PF02798
(GST_N)
PF13410
(GST_C_2)
4 GLY A 220
TYR A 223
LEU A 230
ALA A 227
None
0.86A 1dmaA-4puaA:
undetectable
1dmaA-4puaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py4 POLY [ADP-RIBOSE]
POLYMERASE 14


(Homo sapiens)
PF00644
(PARP)
4 HIS A1682
GLY A1683
TYR A1714
TYR A1727
XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.6A)
0.16A 1dmaA-4py4A:
5.6
1dmaA-4py4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 HIS A  40
GLY A  39
ALA A  37
TYR A  38
None
None
None
LLP  A  34 ( 4.5A)
0.89A 1dmaA-4qhrA:
undetectable
1dmaA-4qhrA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN


(Mycolicibacterium
fortuitum)
PF00722
(Glyco_hydro_16)
4 GLY A 149
TYR A 170
ALA A 150
GLU A 168
GLY  A 149 ( 0.0A)
TYR  A 170 ( 1.3A)
ALA  A 150 ( 0.0A)
GLU  A 168 (-0.5A)
0.90A 1dmaA-4w65A:
undetectable
1dmaA-4w65A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgg DOUBLE BOND
REDUCTASE


(Zingiber
officinale)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
4 GLY A 254
TYR A 234
LEU A 286
GLU A 236
None
0.82A 1dmaA-4wggA:
undetectable
1dmaA-4wggA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC


(Escherichia
coli)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 HIS A  40
GLY A  39
ALA A  37
TYR A  38
None
None
None
PLP  A1001 (-4.4A)
0.88A 1dmaA-4wr3A:
undetectable
1dmaA-4wr3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8k RNA POLYMERASE SIGMA
FACTOR SIGA


(Mycobacterium
tuberculosis)
PF00140
(Sigma70_r1_2)
PF04542
(Sigma70_r2)
4 GLY A 256
ALA A 259
TYR A 258
GLU A 265
None
0.92A 1dmaA-4x8kA:
undetectable
1dmaA-4x8kA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN


(Mycolicibacterium
thermoresistibile)
PF00722
(Glyco_hydro_16)
4 GLY A 126
TYR A 150
ALA A 127
GLU A 148
None
None
None
EDO  A 307 (-3.4A)
0.88A 1dmaA-4xdqA:
undetectable
1dmaA-4xdqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens)
PF00082
(Peptidase_S8)
PF01483
(P_proprotein)
4 GLY A 427
LEU A 337
ALA A 338
TYR A 426
None
0.91A 1dmaA-4z2aA:
undetectable
1dmaA-4z2aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzy POLY [ADP-RIBOSE]
POLYMERASE 2


(Homo sapiens)
PF00644
(PARP)
PF02877
(PARP_reg)
4 HIS A 428
GLY A 429
TYR A 462
TYR A 473
D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.8A)
0.41A 1dmaA-4zzyA:
6.0
1dmaA-4zzyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzy POLY [ADP-RIBOSE]
POLYMERASE 2


(Homo sapiens)
PF00644
(PARP)
PF02877
(PARP_reg)
4 HIS A 428
GLY A 429
TYR A 473
GLU A 558
D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
0.53A 1dmaA-4zzyA:
6.0
1dmaA-4zzyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcz TANKYRASE-2

(Homo sapiens)
PF00644
(PARP)
4 HIS A1031
GLY A1032
TYR A1060
TYR A1071
59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.3A)
0.16A 1dmaA-5dczA:
6.1
1dmaA-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcz TANKYRASE-2

(Homo sapiens)
PF00644
(PARP)
4 HIS A1031
GLY A1032
TYR A1071
GLU A1138
59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
0.75A 1dmaA-5dczA:
6.1
1dmaA-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsy POLY [ADP-RIBOSE]
POLYMERASE 2


(Homo sapiens)
PF00644
(PARP)
4 HIS A 415
GLY A 416
TYR A 449
TYR A 460
UHB  A1001 (-3.7A)
UHB  A1001 (-3.9A)
UHB  A1001 (-3.8A)
UHB  A1001 (-3.4A)
0.31A 1dmaA-5dsyA:
5.8
1dmaA-5dsyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsy POLY [ADP-RIBOSE]
POLYMERASE 2


(Homo sapiens)
PF00644
(PARP)
4 HIS A 415
GLY A 416
TYR A 460
GLU A 545
UHB  A1001 (-3.7A)
UHB  A1001 (-3.9A)
UHB  A1001 (-3.4A)
UHB  A1001 (-3.5A)
0.52A 1dmaA-5dsyA:
5.8
1dmaA-5dsyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eu0 ANTITOXIN 1

(Bartonella
rochalimae)
no annotation 4 GLY B  47
ALA B  49
TYR B  48
GLU B  15
None
0.92A 1dmaA-5eu0B:
undetectable
1dmaA-5eu0B:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 HIS A  52
GLY A  51
ALA A  49
TYR A  50
None
None
None
PLP  A 401 (-4.6A)
0.91A 1dmaA-5facA:
undetectable
1dmaA-5facA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq1 HISTIDINE KINASE

(Geobacillus
thermodenitrificans)
PF13426
(PAS_9)
4 GLY A 220
LEU A 238
ALA A 237
GLU A 246
None
None
None
GOL  A1310 ( 3.9A)
0.86A 1dmaA-5fq1A:
undetectable
1dmaA-5fq1A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE


(Thermococcus
kodakarensis)
PF02272
(DHHA1)
4 GLY A 314
TYR A 325
ALA A 316
GLU A 322
None
0.88A 1dmaA-5ghsA:
undetectable
1dmaA-5ghsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2l NAB2P

(Saccharomyces
cerevisiae)
PF14608
(zf-CCCH_2)
4 HIS A 430
GLY A 418
TYR A 428
GLU A 413
ZN  A 501 (-3.3A)
None
A  G   3 ( 3.9A)
ZN  A 504 (-2.6A)
0.71A 1dmaA-5l2lA:
undetectable
1dmaA-5l2lA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10


(Homo sapiens)
PF00644
(PARP)
5 HIS A 887
GLY A 888
TYR A 919
LEU A 926
TYR A 932
78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.6A)
78P  A1101 (-3.8A)
0.43A 1dmaA-5lx6A:
4.8
1dmaA-5lx6A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdm GLYCOPROTEIN

(Chandipura
vesiculovirus)
no annotation 4 GLY E 200
TYR E 191
LEU E 252
ALA E 199
None
0.72A 1dmaA-5mdmE:
undetectable
1dmaA-5mdmE:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh2 UNCHARACTERIZED
PROTEIN


(Bartonella
henselae)
no annotation 4 GLY B  49
ALA B  51
TYR B  50
GLU B  17
GLY  B  49 ( 0.0A)
ALA  B  51 ( 0.0A)
TYR  B  50 ( 1.3A)
GLU  B  17 ( 0.5A)
0.85A 1dmaA-5nh2B:
undetectable
1dmaA-5nh2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E


(Staphylococcus
aureus)
no annotation 4 GLY A 271
ALA A 273
TYR A 272
GLU A 281
None
0.85A 1dmaA-5xoeA:
undetectable
1dmaA-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xst POLY [ADP-RIBOSE]
POLYMERASE 1


(Homo sapiens)
no annotation 5 HIS A 201
GLY A 202
TYR A 235
TYR A 246
GLU A 327
8E6  A 401 (-3.5A)
8E6  A 401 (-3.9A)
8E6  A 401 (-4.1A)
8E6  A 401 (-3.4A)
8E6  A 401 (-3.9A)
0.46A 1dmaA-5xstA:
6.0
1dmaA-5xstA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1


(Saccharomyces
cerevisiae)
no annotation 4 GLY A  93
TYR A  81
ALA A  90
GLU A  96
None
0.87A 1dmaA-5y58A:
undetectable
1dmaA-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a2f -

(-)
no annotation 4 HIS A  40
GLY A  39
ALA A  37
TYR A  38
None
None
None
LLP  A  34 ( 4.5A)
0.91A 1dmaA-6a2fA:
undetectable
1dmaA-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhv POLY [ADP-RIBOSE]
POLYMERASE 1


(Homo sapiens)
no annotation 5 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
0.45A 1dmaA-6bhvA:
6.0
1dmaA-6bhvA:
undetectable