SIMILAR PATTERNS OF AMINO ACIDS FOR 1DIT_P_2PPP1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA

(Enterococcus
faecium) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU B 111
ILE B 117
ASP B  72
PRO B  71
 None
 1.06A 1ditH-1e4eB:
0.0
1ditP-1e4eB:
undetectable		 1ditH-1e4eB:
20.34
1ditP-1e4eB:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		4 LEU A  92
ILE A 136
GLU A 198
PRO A 180
 None
 1.15A 1ditH-1fd9A:
0.0
1ditP-1fd9A:
undetectable		 1ditH-1fd9A:
19.49
1ditP-1fd9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqo URE2 PROTEIN

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE A 212
TRP A 202
ASP A 204
PRO A 199
 None
 1.16A 1ditH-1hqoA:
0.0
1ditP-1hqoA:
undetectable		 1ditH-1hqoA:
21.50
1ditP-1hqoA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 145
ILE A  69
GLU A  77
PRO A 137
 None
 1.22A 1ditH-1l1fA:
0.0
1ditP-1l1fA:
undetectable		 1ditH-1l1fA:
19.52
1ditP-1l1fA:
3.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 LEU K  99
ILE K 174
TRP K 215
GLU K 217
 None
 0.66A 1ditH-1mkxK:
36.6
1ditP-1mkxK:
undetectable		 1ditH-1mkxK:
87.26
1ditP-1mkxK:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 LEU Q 391
ILE Q 382
GLU Q 439
PRO Q 424
 None
 1.23A 1ditH-1oh2Q:
undetectable
1ditP-1oh2Q:
undetectable		 1ditH-1oh2Q:
21.79
1ditP-1oh2Q:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfh PROTEIN (GELATION
FACTOR)

(Dictyostelium
discoideum) 		PF00630
(Filamin) 		4 LEU A 701
GLU A 724
ASP A 666
PRO A 722
 None
 1.03A 1ditH-1qfhA:
0.0
1ditP-1qfhA:
undetectable		 1ditH-1qfhA:
20.60
1ditP-1qfhA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 LEU A 468
ILE A 414
ASP A 407
PRO A 405
 None
 1.08A 1ditH-1qhgA:
undetectable
1ditP-1qhgA:
undetectable		 1ditH-1qhgA:
16.83
1ditP-1qhgA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 259
ILE A 252
GLU A 223
ASP A 227
 None
 1.06A 1ditH-1qorA:
0.0
1ditP-1qorA:
undetectable		 1ditH-1qorA:
20.82
1ditP-1qorA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR

(Caenorhabditis
elegans) 		PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 LEU A 590
GLU A 606
ASP A 585
PRO A 563
 None
 1.15A 1ditH-1ttuA:
undetectable
1ditP-1ttuA:
undetectable		 1ditH-1ttuA:
20.14
1ditP-1ttuA:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU B 113
GLU B 165
ASP B 166
PRO B 167
 None
 1.03A 1ditH-1umbB:
undetectable
1ditP-1umbB:
undetectable		 1ditH-1umbB:
20.41
1ditP-1umbB:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbc POLIOVIRUS TYPE 3

(Enterovirus C) 		PF00073
(Rhv) 		4 LEU 3 100
ILE 3  53
ASP 3  92
PRO 3  89
 None
 0.99A 1ditH-1vbc3:
undetectable
1ditP-1vbc3:
undetectable		 1ditH-1vbc3:
23.21
1ditP-1vbc3:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 LEU A 175
ILE A 212
ASP A 157
PRO A 158
 None
 1.19A 1ditH-1vm7A:
undetectable
1ditP-1vm7A:
undetectable		 1ditH-1vm7A:
23.22
1ditP-1vm7A:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 LEU B 437
ILE B 497
GLU B 446
ASP B 450
 None
 1.22A 1ditH-1wa5B:
undetectable
1ditP-1wa5B:
undetectable		 1ditH-1wa5B:
18.34
1ditP-1wa5B:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		4 LEU A 292
ILE A 284
GLU A 286
ASP A 268
 None
 1.20A 1ditH-1x3wA:
undetectable
1ditP-1x3wA:
undetectable		 1ditH-1x3wA:
22.06
1ditP-1x3wA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yif BETA-1,4-XYLOSIDASE

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		4 LEU A  45
ILE A 318
GLU A  22
ASP A  23
 None
 1.13A 1ditH-1yifA:
undetectable
1ditP-1yifA:
undetectable		 1ditH-1yifA:
20.49
1ditP-1yifA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 577
ILE A 587
GLU A 583
ASP A 582
 None
 1.22A 1ditH-1z1wA:
undetectable
1ditP-1z1wA:
undetectable		 1ditH-1z1wA:
14.84
1ditP-1z1wA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctf VIGILIN

(Homo sapiens) 		PF00013
(KH_1) 		4 LEU A  37
GLU A  65
ASP A  68
PRO A  34
 None
 1.02A 1ditH-2ctfA:
undetectable
1ditP-2ctfA:
undetectable		 1ditH-2ctfA:
17.05
1ditP-2ctfA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		4 LEU A  84
ILE A 253
GLU A  92
PRO A 220
 None
 1.22A 1ditH-2cuyA:
undetectable
1ditP-2cuyA:
undetectable		 1ditH-2cuyA:
20.36
1ditP-2cuyA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		4 LEU A 386
ILE A 334
ASP A 222
PRO A 219
 None
 1.18A 1ditH-2d7sA:
undetectable
1ditP-2d7sA:
undetectable		 1ditH-2d7sA:
18.60
1ditP-2d7sA:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dag UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00627
(UBA) 		4 LEU A  16
ILE A  14
GLU A  10
ASP A   9
 None
 1.12A 1ditH-2dagA:
undetectable
1ditP-2dagA:
undetectable		 1ditH-2dagA:
14.67
1ditP-2dagA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dit HIV TAT SPECIFIC
FACTOR 1 VARIANT

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A  58
ILE A  20
GLU A  46
ASP A  42
 None
 1.14A 1ditH-2ditA:
undetectable
1ditP-2ditA:
undetectable		 1ditH-2ditA:
20.61
1ditP-2ditA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Homo sapiens) 		PF12796
(Ank_2) 		4 LEU A 167
ILE A 169
GLU A 172
PRO A 212
 None
 1.21A 1ditH-2f37A:
undetectable
1ditP-2f37A:
undetectable		 1ditH-2f37A:
21.19
1ditP-2f37A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpy O-METHYLTRANSFERASE

(Bacillus
halodurans) 		PF01596
(Methyltransf_3) 		4 LEU A  76
ILE A  81
ASP A 128
PRO A  55
 None
 1.23A 1ditH-2gpyA:
undetectable
1ditP-2gpyA:
undetectable		 1ditH-2gpyA:
21.09
1ditP-2gpyA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 ILE A 259
GLU A 255
ASP A 377
PRO A 379
 None
 1.05A 1ditH-2hxgA:
undetectable
1ditP-2hxgA:
undetectable		 1ditH-2hxgA:
19.88
1ditP-2hxgA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		4 LEU A 802
ILE A 816
GLU A1020
ASP A1018
 None
 1.15A 1ditH-2j7nA:
undetectable
1ditP-2j7nA:
undetectable		 1ditH-2j7nA:
14.30
1ditP-2j7nA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot9 HYPOTHETICAL PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF07152
(YaeQ) 		4 LEU A 104
ILE A 121
ASP A  88
PRO A  87
 None
None
None
SRT  A 201 ( 4.0A)
 1.11A 1ditH-2ot9A:
undetectable
1ditP-2ot9A:
undetectable		 1ditH-2ot9A:
21.32
1ditP-2ot9A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 LEU A1075
ILE A 582
GLU A1081
ASP A1085
 None
 1.15A 1ditH-2po4A:
undetectable
1ditP-2po4A:
undetectable		 1ditH-2po4A:
12.35
1ditP-2po4A:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		4 LEU A 373
ILE A 359
ASP A 546
PRO A 519
 None
 0.95A 1ditH-2x24A:
undetectable
1ditP-2x24A:
undetectable		 1ditH-2x24A:
14.82
1ditP-2x24A:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 LEU A 191
ILE A  51
GLU A 203
PRO A 190
 None
 1.17A 1ditH-2xhyA:
undetectable
1ditP-2xhyA:
undetectable		 1ditH-2xhyA:
20.71
1ditP-2xhyA:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 LEU A  80
GLU A 342
ASP A 354
PRO A 353
 None
 1.20A 1ditH-2yylA:
undetectable
1ditP-2yylA:
undetectable		 1ditH-2yylA:
19.26
1ditP-2yylA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 LEU A 272
ILE A 456
GLU A 457
PRO A 461
 None
 1.06A 1ditH-3al0A:
undetectable
1ditP-3al0A:
undetectable		 1ditH-3al0A:
17.90
1ditP-3al0A:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqw PUTATIVE CAPSID
PROTEIN OF PROPHAGE

(Escherichia
coli) 		PF03864
(Phage_cap_E) 		4 LEU A 217
ILE A 350
ASP A 192
PRO A 189
 None
 1.20A 1ditH-3bqwA:
undetectable
1ditP-3bqwA:
undetectable		 1ditH-3bqwA:
20.87
1ditP-3bqwA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
fabrum) 		PF07229
(VirE2) 		4 LEU A 515
ILE A 454
ASP A 466
PRO A 465
 None
 1.02A 1ditH-3btpA:
undetectable
1ditP-3btpA:
undetectable		 1ditH-3btpA:
18.35
1ditP-3btpA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db7 PUTATIVE
CALCIUM-REGULATED
PERIPLASMIC PROTEIN

(Bacteroides
thetaiotaomicron) 		PF11396
(PepSY_like) 		4 ILE A  65
GLU A  63
ASP A  23
PRO A  25
 None
CA  A   1 (-3.2A)
None
None
 1.14A 1ditH-3db7A:
undetectable
1ditP-3db7A:
undetectable		 1ditH-3db7A:
22.53
1ditP-3db7A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A 297
ILE A 272
GLU A 268
ASP A 260
 None
 0.96A 1ditH-3hn2A:
undetectable
1ditP-3hn2A:
undetectable		 1ditH-3hn2A:
24.84
1ditP-3hn2A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp7 HEMOLYSIN, PUTATIVE

(Streptococcus
thermophilus) 		PF01479
(S4)
PF01728
(FtsJ) 		4 LEU A 148
ILE A  87
ASP A 143
PRO A 141
 None
 1.12A 1ditH-3hp7A:
undetectable
1ditP-3hp7A:
undetectable		 1ditH-3hp7A:
18.24
1ditP-3hp7A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ius UNCHARACTERIZED
CONSERVED PROTEIN

(Ruegeria
pomeroyi) 		no annotation 4 LEU A  50
ILE A  41
ASP A  36
PRO A  35
 None
 1.04A 1ditH-3iusA:
undetectable
1ditP-3iusA:
undetectable		 1ditH-3iusA:
20.77
1ditP-3iusA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2d ABC-TYPE METAL ION
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Vibrio
vulnificus) 		PF03180
(Lipoprotein_9) 		4 LEU A 163
GLU A  97
ASP A  93
PRO A  90
 None
 1.23A 1ditH-3k2dA:
undetectable
1ditP-3k2dA:
undetectable		 1ditH-3k2dA:
22.96
1ditP-3k2dA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 LEU A 315
ILE A 349
ASP A 330
PRO A 329
 None
 1.20A 1ditH-3mfdA:
undetectable
1ditP-3mfdA:
undetectable		 1ditH-3mfdA:
21.64
1ditP-3mfdA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 LEU A 239
ILE A 242
ASP A 207
PRO A 210
 None
 1.22A 1ditH-3n71A:
undetectable
1ditP-3n71A:
undetectable		 1ditH-3n71A:
17.37
1ditP-3n71A:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onk EPSIN-3

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		4 LEU A 147
ILE A 153
GLU A 103
ASP A 107
 None
 1.01A 1ditH-3onkA:
undetectable
1ditP-3onkA:
undetectable		 1ditH-3onkA:
22.78
1ditP-3onkA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p83 RIBONUCLEASE HII

(Archaeoglobus
fulgidus) 		PF01351
(RNase_HII) 		4 LEU D 110
ILE D 106
ASP D 104
PRO D 103
 None
 1.12A 1ditH-3p83D:
undetectable
1ditP-3p83D:
undetectable		 1ditH-3p83D:
24.26
1ditP-3p83D:
9.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU B  99
ILE B 174
TRP B 215
GLU B 217
 None
 0.58A 1ditH-3r3gB:
44.2
1ditP-3r3gB:
undetectable		 1ditH-3r3gB:
97.68
1ditP-3r3gB:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		4 LEU A 242
ILE A 291
ASP A 320
PRO A 275
 None
 1.22A 1ditH-3s5nA:
undetectable
1ditP-3s5nA:
undetectable		 1ditH-3s5nA:
20.13
1ditP-3s5nA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 LEU A 213
ILE A 271
ASP A 276
PRO A 274
 None
 1.23A 1ditH-3s6kA:
undetectable
1ditP-3s6kA:
undetectable		 1ditH-3s6kA:
19.79
1ditP-3s6kA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 108
ILE A 114
ASP A  69
PRO A  68
 None
 1.22A 1ditH-3se7A:
undetectable
1ditP-3se7A:
undetectable		 1ditH-3se7A:
22.03
1ditP-3se7A:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 ILE A 826
TRP A 806
ASP A 754
PRO A 753
 None
 1.13A 1ditH-3sfzA:
undetectable
1ditP-3sfzA:
undetectable		 1ditH-3sfzA:
12.04
1ditP-3sfzA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smv S-(-)-AZETIDINE-2-CA
RBOXYLATE HYDROLASE

(Pseudomonas sp.
AC2) 		PF13419
(HAD_2) 		4 ILE A  24
TRP A  98
ASP A  19
PRO A  99
 None
None
GOL  A 306 ( 4.7A)
None
 1.23A 1ditH-3smvA:
undetectable
1ditP-3smvA:
undetectable		 1ditH-3smvA:
23.35
1ditP-3smvA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Francisella
tularensis) 		PF00793
(DAHP_synth_1) 		4 LEU A 184
ILE A 167
GLU A 148
PRO A 155
 None
None
ACT  A1002 ( 4.6A)
None
 1.20A 1ditH-3tqkA:
undetectable
1ditP-3tqkA:
undetectable		 1ditH-3tqkA:
20.40
1ditP-3tqkA:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u62 SHIKIMATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 LEU A 157
GLU A 162
ASP A 161
PRO A 184
 None
 1.23A 1ditH-3u62A:
undetectable
1ditP-3u62A:
undetectable		 1ditH-3u62A:
23.67
1ditP-3u62A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 554
ILE A 618
ASP A 612
PRO A 613
 None
 1.16A 1ditH-3vrbA:
undetectable
1ditP-3vrbA:
undetectable		 1ditH-3vrbA:
17.01
1ditP-3vrbA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 4 LEU A  80
ILE A  82
ASP A  87
PRO A  85
 None
 1.17A 1ditH-3w36A:
undetectable
1ditP-3w36A:
undetectable		 1ditH-3w36A:
17.10
1ditP-3w36A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuc GALECTIN

(Xenopus laevis) 		PF00337
(Gal-bind_lectin) 		4 LEU A  90
ILE A  61
ASP A 104
PRO A 103
 None
 1.21A 1ditH-3wucA:
undetectable
1ditP-3wucA:
undetectable		 1ditH-3wucA:
16.34
1ditP-3wucA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuc GALECTIN

(Xenopus laevis) 		PF00337
(Gal-bind_lectin) 		4 LEU A  90
ILE A 108
ASP A 104
PRO A 103
 None
 1.19A 1ditH-3wucA:
undetectable
1ditP-3wucA:
undetectable		 1ditH-3wucA:
16.34
1ditP-3wucA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		4 LEU A 276
ILE A  33
ASP A 302
PRO A 303
 None
 0.87A 1ditH-3zdpA:
undetectable
1ditP-3zdpA:
undetectable		 1ditH-3zdpA:
20.81
1ditP-3zdpA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 314
ILE A 316
GLU A 186
ASP A 187
 None
 1.19A 1ditH-4a4lA:
undetectable
1ditP-4a4lA:
undetectable		 1ditH-4a4lA:
19.94
1ditP-4a4lA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		4 LEU A 204
ILE A 207
ASP A 184
PRO A 187
 None
 1.22A 1ditH-4au7A:
undetectable
1ditP-4au7A:
undetectable		 1ditH-4au7A:
21.95
1ditP-4au7A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  53
ILE A 425
TRP A  57
GLU A  89
 None
TPP  A1589 ( 4.8A)
None
None
 1.16A 1ditH-4d5gA:
undetectable
1ditP-4d5gA:
undetectable		 1ditH-4d5gA:
19.28
1ditP-4d5gA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN

(Streptomyces
himastatinicus) 		PF00067
(p450) 		4 LEU A 250
ILE A 124
GLU A 123
PRO A 378
 None
 1.03A 1ditH-4ggvA:
undetectable
1ditP-4ggvA:
undetectable		 1ditH-4ggvA:
20.43
1ditP-4ggvA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus) 		PF01403
(Sema) 		4 ILE A 140
TRP A  93
ASP A  75
PRO A  94
 None
None
None
NAG  A 801 ( 4.3A)
 1.20A 1ditH-4gz8A:
undetectable
1ditP-4gz8A:
undetectable		 1ditH-4gz8A:
15.07
1ditP-4gz8A:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis) 		PF00161
(RIP) 		4 LEU A 107
ILE A  53
GLU A  99
ASP A 100
 None
 1.20A 1ditH-4imvA:
undetectable
1ditP-4imvA:
undetectable		 1ditH-4imvA:
21.16
1ditP-4imvA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqh DYSFERLIN

(Homo sapiens) 		PF00168
(C2) 		4 LEU A  83
GLU A  75
ASP A  23
PRO A  24
 None
 1.16A 1ditH-4iqhA:
undetectable
1ditP-4iqhA:
undetectable		 1ditH-4iqhA:
21.81
1ditP-4iqhA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00245
(Alk_phosphatase) 		4 LEU A 253
GLU A 216
ASP A 285
PRO A 286
 None
MG  A 502 (-2.6A)
MG  A 502 (-3.2A)
None
 1.23A 1ditH-4kjdA:
undetectable
1ditP-4kjdA:
undetectable		 1ditH-4kjdA:
17.74
1ditP-4kjdA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans) 		PF01012
(ETF) 		4 LEU B 138
ILE B 105
ASP B 112
PRO B 172
 None
 1.14A 1ditH-4kpuB:
undetectable
1ditP-4kpuB:
undetectable		 1ditH-4kpuB:
23.38
1ditP-4kpuB:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LEU A 355
ILE A 375
ASP A 371
PRO A 370
 None
 0.95A 1ditH-4lvcA:
undetectable
1ditP-4lvcA:
undetectable		 1ditH-4lvcA:
21.49
1ditP-4lvcA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1b POLYSACCHARIDE
DEACETYLASE

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		4 LEU A 145
ILE A 106
ASP A 101
PRO A 100
 None
 1.14A 1ditH-4m1bA:
undetectable
1ditP-4m1bA:
undetectable		 1ditH-4m1bA:
21.51
1ditP-4m1bA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		4 LEU A 476
GLU A 508
ASP A 509
PRO A 510
 None
 1.21A 1ditH-4obsA:
undetectable
1ditP-4obsA:
undetectable		 1ditH-4obsA:
16.98
1ditP-4obsA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		4 LEU A 264
ILE A 298
GLU A 284
ASP A 288
 None
 1.18A 1ditH-4p6vA:
undetectable
1ditP-4p6vA:
undetectable		 1ditH-4p6vA:
19.02
1ditP-4p6vA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		4 LEU 3 113
ILE 3 189
ASP 3  91
PRO 3  88
 None
 1.14A 1ditH-4q4y3:
undetectable
1ditP-4q4y3:
undetectable		 1ditH-4q4y3:
21.60
1ditP-4q4y3:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF16010
(CDH-cyt) 		4 LEU A  79
GLU A 106
ASP A 103
PRO A 102
 HEM  A 401 ( 3.6A)
None
None
HEM  A 401 ( 4.7A)
 1.22A 1ditH-4qi3A:
undetectable
1ditP-4qi3A:
undetectable		 1ditH-4qi3A:
21.00
1ditP-4qi3A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 LEU A 135
ILE A 199
GLU A 201
ASP A 141
 None
 1.23A 1ditH-4qs9A:
undetectable
1ditP-4qs9A:
undetectable		 1ditH-4qs9A:
21.25
1ditP-4qs9A:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u49 PECTATE LYASE

(Pectobacterium
carotovorum) 		PF03211
(Pectate_lyase) 		4 LEU A 144
ILE A 169
ASP A 176
PRO A 154
 None
 1.12A 1ditH-4u49A:
undetectable
1ditP-4u49A:
undetectable		 1ditH-4u49A:
23.45
1ditP-4u49A:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmd ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		4 LEU A 254
ILE A 300
ASP A 295
PRO A 293
 None
 1.22A 1ditH-4wmdA:
11.9
1ditP-4wmdA:
undetectable		 1ditH-4wmdA:
19.63
1ditP-4wmdA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi9 MCG133388, ISOFORM
CRA_T

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 LEU A  46
ILE A  95
GLU A   9
ASP A  63
 None
None
CA  A 504 ( 2.8A)
CA  A 506 (-3.1A)
 1.15A 1ditH-4zi9A:
undetectable
1ditP-4zi9A:
undetectable		 1ditH-4zi9A:
23.19
1ditP-4zi9A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		4 LEU A 208
GLU A 201
ASP A  77
PRO A  74
 None
 0.97A 1ditH-4zowA:
undetectable
1ditP-4zowA:
undetectable		 1ditH-4zowA:
20.11
1ditP-4zowA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a52 CALCIUM-DEPENDENT
LIPID-BINDING
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00168
(C2) 		4 LEU A  18
ILE A  20
ASP A  27
PRO A  28
 None
None
CA  A1164 (-3.7A)
None
 0.86A 1ditH-5a52A:
undetectable
1ditP-5a52A:
undetectable		 1ditH-5a52A:
20.99
1ditP-5a52A:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus) 		PF00266
(Aminotran_5) 		4 LEU A 277
ILE A  68
GLU A 285
PRO A 218
 None
None
None
LLP  A 216 ( 4.0A)
 1.15A 1ditH-5b7sA:
undetectable
1ditP-5b7sA:
undetectable		 1ditH-5b7sA:
21.34
1ditP-5b7sA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpr HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1

(Homo sapiens) 		PF00856
(SET) 		4 LEU B 294
ILE B 297
ASP B 274
PRO B 277
 None
 1.23A 1ditH-5cprB:
undetectable
1ditP-5cprB:
undetectable		 1ditH-5cprB:
22.53
1ditP-5cprB:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 LEU A 522
ILE A 376
ASP A 424
PRO A 425
 None
 1.23A 1ditH-5df0A:
undetectable
1ditP-5df0A:
undetectable		 1ditH-5df0A:
17.85
1ditP-5df0A:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 4 LEU C 394
ILE C 348
GLU C 328
ASP C 325
 None
 1.03A 1ditH-5elpC:
undetectable
1ditP-5elpC:
undetectable		 1ditH-5elpC:
18.37
1ditP-5elpC:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 LEU D 445
ILE D 375
ASP D 380
PRO D 381
 None
 1.20A 1ditH-5fl7D:
0.5
1ditP-5fl7D:
undetectable		 1ditH-5fl7D:
18.07
1ditP-5fl7D:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 ILE A 176
GLU A 268
ASP A  57
PRO A 127
 None
ACT  A 405 ( 3.8A)
GOL  A 403 (-2.9A)
None
 1.21A 1ditH-5gllA:
undetectable
1ditP-5gllA:
undetectable		 1ditH-5gllA:
22.87
1ditP-5gllA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17

(Sphingomonas
sp. PAMC 26605) 		PF00067
(p450) 		4 LEU A  18
ILE A 321
TRP A  24
PRO A  27
 None
 1.23A 1ditH-5h1zA:
undetectable
1ditP-5h1zA:
undetectable		 1ditH-5h1zA:
17.85
1ditP-5h1zA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 4 ILE B 317
GLU B  81
ASP B 320
PRO B 321
 None
 1.13A 1ditH-5ivlB:
undetectable
1ditP-5ivlB:
undetectable		 1ditH-5ivlB:
19.36
1ditP-5ivlB:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		4 LEU A1186
ILE A1184
GLU A1077
PRO A1193
 None
 1.20A 1ditH-5jbeA:
undetectable
1ditP-5jbeA:
undetectable		 1ditH-5jbeA:
14.61
1ditP-5jbeA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7

(Zea mays) 		PF00248
(Aldo_ket_red) 		4 LEU A 142
ILE A 110
ASP A  88
PRO A  90
 None
 1.01A 1ditH-5jh1A:
undetectable
1ditP-5jh1A:
undetectable		 1ditH-5jh1A:
21.86
1ditP-5jh1A:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 ILE A 139
GLU A 189
ASP A  34
PRO A  95
 TRS  A 601 (-4.8A)
EDO  A 603 ( 2.9A)
TRS  A 601 (-2.8A)
None
 1.20A 1ditH-5jowA:
undetectable
1ditP-5jowA:
undetectable		 1ditH-5jowA:
20.52
1ditP-5jowA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1

(Sorangium
cellulosum) 		PF00067
(p450) 		4 LEU A 312
ILE A 372
ASP A 308
PRO A 309
 None
 0.87A 1ditH-5livA:
undetectable
1ditP-5livA:
undetectable		 1ditH-5livA:
19.33
1ditP-5livA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 4 LEU A  62
GLU A  68
ASP A  69
PRO A  70
 None
 0.96A 1ditH-5ol0A:
undetectable
1ditP-5ol0A:
undetectable		 1ditH-5ol0A:
16.13
1ditP-5ol0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ons DENSITY-REGULATED
PROTEIN
MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1

(Homo sapiens) 		no annotation 4 LEU A 170
ILE A 102
GLU B  45
PRO B  40
 None
 0.99A 1ditH-5onsA:
undetectable
1ditP-5onsA:
undetectable		 1ditH-5onsA:
14.46
1ditP-5onsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 261
ILE A 293
GLU A 337
ASP A 376
 None
 1.10A 1ditH-5vm1A:
undetectable
1ditP-5vm1A:
undetectable		 1ditH-5vm1A:
20.41
1ditP-5vm1A:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 4 LEU A 316
ILE A 250
ASP A 267
PRO A 268
 None
 0.84A 1ditH-5w19A:
undetectable
1ditP-5w19A:
undetectable		 1ditH-5w19A:
15.10
1ditP-5w19A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq3 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Corynebacterium
glutamicum) 		PF03641
(Lysine_decarbox) 		4 LEU A  51
ILE A  53
ASP A  46
PRO A  47
 None
 1.19A 1ditH-5wq3A:
undetectable
1ditP-5wq3A:
undetectable		 1ditH-5wq3A:
22.49
1ditP-5wq3A:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		4 LEU A  22
ILE A 135
GLU A  15
ASP A  14
 None
 1.02A 1ditH-5xa5A:
undetectable
1ditP-5xa5A:
undetectable		 1ditH-5xa5A:
20.13
1ditP-5xa5A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zi9 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Streptomyces
coelicolor) 		no annotation 4 LEU A  55
ILE A  57
ASP A  50
PRO A  51
 None
 1.22A 1ditH-5zi9A:
undetectable
1ditP-5zi9A:
undetectable		 1ditH-5zi9A:
13.13
1ditP-5zi9A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 4 LEU B 167
ILE A 178
GLU A 176
PRO B 166
 None
 1.18A 1ditH-6cxhB:
undetectable
1ditP-6cxhB:
undetectable		 1ditH-6cxhB:
17.97
1ditP-6cxhB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 4 LEU A  55
ILE A  38
TRP A  59
PRO A  78
 None
 1.07A 1ditH-6d95A:
undetectable
1ditP-6d95A:
undetectable		 1ditH-6d95A:
undetectable
1ditP-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni) 		no annotation 4 LEU A 262
ILE A 189
GLU A 275
PRO A 270
 None
None
UDP  A 401 (-2.7A)
NA  A 403 (-4.3A)
 1.13A 1ditH-6ejjA:
undetectable
1ditP-6ejjA:
undetectable		 1ditH-6ejjA:
15.81
1ditP-6ejjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		4 LEU B 217
ILE B 280
ASP B 200
PRO B 201
 None
 0.86A 1ditH-6reqB:
undetectable
1ditP-6reqB:
undetectable		 1ditH-6reqB:
17.19
1ditP-6reqB:
2.86