SIMILAR PATTERNS OF AMINO ACIDS FOR 1DFO_B_FFOB2002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		5 GLY A 203
HIS A 211
ASN A 233
PHE A 167
ARG A 214
 None
 0.99A 1dfoB-12asA:
undetectable		 1dfoB-12asA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		5 GLY A  56
LEU A 228
VAL A 234
ASN A  22
SER A  66
 None
 1.15A 1dfoB-1a4sA:
0.0		 1dfoB-1a4sA:
24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		7 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 347
ARG A 363
 None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
 0.84A 1dfoB-1cj0A:
51.5		 1dfoB-1cj0A:
45.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 298
LEU A 307
VAL A 253
ALA A 457
PHE A 286
 None
 1.09A 1dfoB-1coyA:
undetectable		 1dfoB-1coyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		5 LEU A  85
GLY A  42
LEU A  36
SER A  30
PRO A  31
 None
 1.06A 1dfoB-1esoA:
undetectable		 1dfoB-1esoA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 GLY A 111
VAL A 242
ALA A 167
ASN A 171
PRO A 179
 None
 1.07A 1dfoB-1ex9A:
1.6		 1dfoB-1ex9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Staphylococcus
aureus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 GLY A 263
VAL A 293
ASN A 277
SER A 268
PHE A 274
 None
None
None
None
FAD  A 401 (-4.6A)
 1.08A 1dfoB-1hskA:
undetectable		 1dfoB-1hskA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxn HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		5 LEU A 233
LEU A 430
SER A 226
SER A 236
PHE A 249
 None
 1.11A 1dfoB-1hxnA:
undetectable		 1dfoB-1hxnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imj CCG1-INTERACTING
FACTOR B

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		5 LEU A  69
GLY A  71
SER A  75
ALA A  78
PHE A 120
 None
 1.11A 1dfoB-1imjA:
1.0		 1dfoB-1imjA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 LEU A 579
GLY A 577
LEU A 583
ALA A 433
PHE A 481
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 1.06A 1dfoB-1kwgA:
undetectable		 1dfoB-1kwgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 GLY A 391
LEU A 400
VAL A 403
SER A 319
ALA A 317
 None
 0.98A 1dfoB-1l0wA:
undetectable		 1dfoB-1l0wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		5 LEU A1127
GLY A1129
ALA A1132
ASN A1053
SER A1047
 None
 1.15A 1dfoB-1lu4A:
undetectable		 1dfoB-1lu4A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		5 LEU A 359
GLY A 296
HIS A 351
ALA A  39
PHE A 432
 None
 1.15A 1dfoB-1mf1A:
undetectable		 1dfoB-1mf1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 342
GLY A 344
LEU A 338
VAL A 395
SER A 310
 None
 0.97A 1dfoB-1muuA:
3.4		 1dfoB-1muuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 GLY A 416
LEU A 390
VAL A 392
ALA A 429
SER A 420
 None
 0.88A 1dfoB-1nr0A:
undetectable		 1dfoB-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 LEU A 417
GLY A 416
LEU A 390
VAL A 392
SER A 420
 None
 0.94A 1dfoB-1nr0A:
undetectable		 1dfoB-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 GLY A  98
LEU A  69
VAL A  67
SER A  99
SER A 387
 None
 1.10A 1dfoB-1nr6A:
undetectable		 1dfoB-1nr6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6m RIBONUCLEASE PH

(Pseudomonas
aeruginosa) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 176
GLY A 125
ASN A 189
PHE A 210
ARG A 127
 None
PO4  A 242 (-3.6A)
PO4  A 242 ( 4.9A)
None
PO4  A 242 (-3.8A)
 1.12A 1dfoB-1r6mA:
undetectable		 1dfoB-1r6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 244
GLY A  59
HIS A 245
SER A 255
PRO A 254
 None
 1.09A 1dfoB-1si8A:
undetectable		 1dfoB-1si8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		5 GLY A 401
VAL A 461
SER A 428
ALA A 427
PHE A 367
 SAH  A 801 ( 4.2A)
None
None
None
None
 1.01A 1dfoB-1u2zA:
undetectable		 1dfoB-1u2zA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wtd ECOO109IR

(Escherichia
coli) 		PF14511
(RE_EcoO109I) 		5 GLY A  86
HIS A 111
LEU A 123
VAL A 159
SER A 205
 None
 1.09A 1dfoB-1wtdA:
undetectable		 1dfoB-1wtdA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 GLY A  19
SER A  21
ALA A  22
SER A 189
PRO A 190
 None
None
None
None
NDP  A1278 (-4.1A)
 1.12A 1dfoB-1xhlA:
3.0		 1dfoB-1xhlA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		5 GLY A 199
SER A 142
ALA A 141
SER A 271
PHE A 245
 None
None
NAD  A1378 (-3.6A)
None
None
 1.14A 1dfoB-2c5aA:
undetectable		 1dfoB-2c5aA:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		8 LEU A 117
GLY A 120
HIS A 122
LEU A 123
VAL A 129
SER A 172
ALA A 173
ARG A 358
 None
None
PLP  A 510 (-3.5A)
None
None
PLP  A 510 ( 3.2A)
None
SO4  A2520 (-2.9A)
 0.47A 1dfoB-2dkjA:
61.9		 1dfoB-2dkjA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		7 LEU A 117
GLY A 120
HIS A 122
SER A 172
ALA A 173
ASN A 342
ARG A 358
 None
None
PLP  A 510 (-3.5A)
PLP  A 510 ( 3.2A)
None
None
SO4  A2520 (-2.9A)
 0.84A 1dfoB-2dkjA:
61.9		 1dfoB-2dkjA:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqw DIHYDROPTEROATE
SYNTHASE

(Thermus
thermophilus) 		PF00809
(Pterin_bind) 		5 LEU A  32
GLY A  33
LEU A 266
VAL A 195
ALA A  66
 None
 1.06A 1dfoB-2dqwA:
undetectable		 1dfoB-2dqwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		5 LEU A 451
GLY A 449
LEU A 372
SER A 585
ALA A 584
 None
 1.01A 1dfoB-2e28A:
undetectable		 1dfoB-2e28A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A  91
LEU A 287
SER A 301
ALA A 302
SER A  70
 None
 1.01A 1dfoB-2glxA:
undetectable		 1dfoB-2glxA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mev MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP2)

(Cardiovirus A) 		PF00073
(Rhv) 		5 LEU 2 222
LEU 2 232
ALA 2 220
SER 2 225
PHE 2 121
 None
 1.14A 1dfoB-2mev2:
undetectable		 1dfoB-2mev2:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		5 GLY A 196
LEU A 413
SER A 194
ALA A 195
SER A 116
 GLY  A 196 ( 0.0A)
LEU  A 413 ( 0.6A)
SER  A 194 ( 0.0A)
ALA  A 195 ( 0.0A)
SER  A 116 ( 0.0A)
 0.99A 1dfoB-2ogsA:
undetectable		 1dfoB-2ogsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Escherichia
coli) 		PF04381
(RdgC) 		5 LEU A 293
GLY A 296
LEU A 289
ALA A 186
SER A 249
 None
 1.13A 1dfoB-2owlA:
undetectable		 1dfoB-2owlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		5 LEU A 297
GLY A 295
LEU A 288
VAL A 304
PRO A 195
 None
 1.10A 1dfoB-2rkbA:
undetectable		 1dfoB-2rkbA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rt3 NEGATIVE REGULATOR
OF DIFFERENTIATION 1

(Schizosaccharomyces
pombe) 		PF00076
(RRM_1) 		5 LEU A 226
GLY A 230
LEU A 261
ALA A 253
PHE A 245
 None
 1.05A 1dfoB-2rt3A:
undetectable		 1dfoB-2rt3A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		5 LEU A 105
VAL A 110
SER A 266
ALA A 268
PRO A 135
 None
 1.16A 1dfoB-2v6jA:
undetectable		 1dfoB-2v6jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhq NTPASE P4

(Pseudomonas
phage phi12) 		PF11602
(NTPase_P4) 		5 GLY A 219
LEU A 214
VAL A 194
ALA A 222
SER A 232
 None
 1.09A 1dfoB-2vhqA:
undetectable		 1dfoB-2vhqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
 None
 0.93A 1dfoB-2vk4A:
1.7		 1dfoB-2vk4A:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		8 GLY A 120
HIS A 122
LEU A 123
VAL A 129
SER A 172
ALA A 173
ASN A 341
ARG A 357
 None
PLP  A 501 ( 3.4A)
None
None
ALO  A 502 (-3.9A)
None
None
ALO  A 502 (-3.0A)
 0.77A 1dfoB-2vmxA:
62.3		 1dfoB-2vmxA:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		8 GLY A 120
HIS A 122
SER A 172
ALA A 173
ASN A 341
SER A 349
PRO A 350
ARG A 357
 None
PLP  A 501 ( 3.4A)
ALO  A 502 (-3.9A)
None
None
None
None
ALO  A 502 (-3.0A)
 0.66A 1dfoB-2vmxA:
62.3		 1dfoB-2vmxA:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		6 LEU A 117
GLY A 120
HIS A 122
LEU A 123
VAL A 129
SER A 172
 None
None
PLP  A 501 ( 3.4A)
None
None
ALO  A 502 (-3.9A)
 1.33A 1dfoB-2vmxA:
62.3		 1dfoB-2vmxA:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 LEU A1497
GLY A1499
LEU A1493
SER A1412
PRO A1413
 None
 0.94A 1dfoB-2vz9A:
undetectable		 1dfoB-2vz9A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 444
LEU A 505
VAL A 503
ALA A 451
SER A 480
 None
 1.14A 1dfoB-2xr1A:
undetectable		 1dfoB-2xr1A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		5 LEU B 610
LEU B 613
VAL B 570
SER B 599
PHE B 596
 None
 1.10A 1dfoB-2xwuB:
undetectable		 1dfoB-2xwuB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Agrobacterium
fabrum) 		PF00440
(TetR_N) 		5 LEU A 212
GLY A 213
HIS A 209
LEU A 200
VAL A 196
 None
 1.14A 1dfoB-3c2bA:
undetectable		 1dfoB-3c2bA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 GLY A 124
ASN A 347
SER A 355
PRO A 356
ARG A 363
 None
 1.03A 1dfoB-3g8mA:
58.1		 1dfoB-3g8mA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 GLY A 124
HIS A 126
LEU A 127
ALA A 176
ARG A 363
 None
PLP  A 418 (-4.1A)
PLP  A 418 ( 4.7A)
None
None
 1.04A 1dfoB-3g8mA:
58.1		 1dfoB-3g8mA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 GLY A 124
HIS A 126
LEU A 127
VAL A 133
ARG A 363
 None
PLP  A 418 (-4.1A)
PLP  A 418 ( 4.7A)
None
None
 0.65A 1dfoB-3g8mA:
58.1		 1dfoB-3g8mA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1

(Mycobacterium
tuberculosis) 		PF00464
(SHMT) 		6 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
 None
None
LLP  A 227 ( 3.6A)
None
None
None
 0.94A 1dfoB-3h7fA:
55.9		 1dfoB-3h7fA:
51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1

(Mycobacterium
tuberculosis) 		PF00464
(SHMT) 		6 LEU A 118
HIS A 123
LEU A 124
SER A 173
ALA A 174
ARG A 363
 None
LLP  A 227 ( 3.6A)
None
None
None
None
 1.36A 1dfoB-3h7fA:
55.9		 1dfoB-3h7fA:
51.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 LEU A  41
GLY A  39
LEU A  47
ALA A  38
PHE A 320
 None
 0.96A 1dfoB-3i45A:
4.7		 1dfoB-3i45A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k10 PROTEIN STN1

(Saccharomyces
cerevisiae) 		PF12659
(Stn1_C) 		5 LEU A 323
GLY A 325
LEU A 319
VAL A 377
SER A 332
 None
 0.98A 1dfoB-3k10A:
undetectable		 1dfoB-3k10A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7w PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1704

(Streptococcus
mutans) 		PF03551
(PadR) 		5 LEU A  56
GLY A  54
LEU A  47
ALA A  53
SER A  19
 None
 1.13A 1dfoB-3l7wA:
undetectable		 1dfoB-3l7wA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  50
GLY A  53
VAL A  35
SER A  19
PHE A  15
 None
 1.12A 1dfoB-3pqdA:
undetectable		 1dfoB-3pqdA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN

(Leishmania
major) 		PF00782
(DSPc) 		5 LEU A  47
VAL A  60
ALA A 119
SER A  28
PRO A  27
 None
None
THJ  A 170 (-3.7A)
None
None
 0.96A 1dfoB-3s4oA:
undetectable		 1dfoB-3s4oA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sge HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H 140
VAL H 195
ALA H 132
ASN H 135
SER H 188
 None
 1.09A 1dfoB-3sgeH:
undetectable		 1dfoB-3sgeH:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		5 LEU A  98
GLY A  99
LEU A  50
VAL A  45
SER A  38
 None
 0.99A 1dfoB-3vylA:
undetectable		 1dfoB-3vylA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		5 LEU A  98
GLY A 100
LEU A  50
VAL A  45
SER A  38
 None
 1.07A 1dfoB-3vylA:
undetectable		 1dfoB-3vylA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		5 LEU A 563
LEU A 567
VAL A 474
ALA A 497
SER A 282
 None
None
None
None
ANP  A 700 (-3.6A)
 1.01A 1dfoB-4a5aA:
undetectable		 1dfoB-4a5aA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF01208
(URO-D) 		5 LEU A  17
GLY A  19
LEU A  13
VAL A 145
SER A 261
 None
 0.91A 1dfoB-4ay7A:
undetectable		 1dfoB-4ay7A:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 GLY A 119
HIS A 121
VAL A 127
ASN A 346
ARG A 363
 None
 0.87A 1dfoB-4bhdA:
48.3		 1dfoB-4bhdA:
36.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE

(Mycobacterium
tuberculosis) 		PF02585
(PIG-L) 		5 LEU A  79
LEU A  76
VAL A  37
ALA A 239
SER A  20
 None
 1.11A 1dfoB-4ewlA:
undetectable		 1dfoB-4ewlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		5 GLY A 153
LEU A 128
VAL A  96
SER A 150
ALA A 151
 None
 1.15A 1dfoB-4f48A:
undetectable		 1dfoB-4f48A:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		7 GLY A 124
SER A 176
ALA A 177
ASN A 346
SER A 354
PRO A 355
ARG A 362
 None
 1.07A 1dfoB-4j5uA:
60.9		 1dfoB-4j5uA:
56.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		7 GLY A 124
SER A 176
ALA A 177
SER A 354
PRO A 355
PHE A 356
ARG A 362
 None
 0.96A 1dfoB-4j5uA:
60.9		 1dfoB-4j5uA:
56.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		7 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.97A 1dfoB-4j5uA:
60.9		 1dfoB-4j5uA:
56.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		7 LEU A 121
GLY A 124
SER A 176
ALA A 177
SER A 354
PHE A 356
ARG A 362
 None
 1.12A 1dfoB-4j5uA:
60.9		 1dfoB-4j5uA:
56.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		6 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ARG A 371
 None
None
PLP  A 701 (-3.6A)
None
None
None
 0.68A 1dfoB-4o6zA:
55.1		 1dfoB-4o6zA:
38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		5 LEU A 124
GLY A 127
VAL A 141
ASN A 356
ARG A 371
 None
 1.07A 1dfoB-4o6zA:
55.1		 1dfoB-4o6zA:
38.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio
vulnificus) 		PF05134
(T2SSL) 		5 LEU X 140
LEU X  64
VAL X  62
SER X 163
SER X 227
 None
 1.12A 1dfoB-4phtX:
undetectable		 1dfoB-4phtX:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudarthrobacter
chlorophenolicus) 		PF01547
(SBP_bac_1) 		5 LEU A 140
GLY A 144
LEU A 350
VAL A 346
PHE A 157
 None
 1.04A 1dfoB-4r2fA:
undetectable		 1dfoB-4r2fA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhm ARGINASE

(Trypanosoma
brucei) 		PF00491
(Arginase) 		5 LEU A 165
GLY A 168
LEU A 161
VAL A 154
PHE A 195
 None
 1.16A 1dfoB-4rhmA:
undetectable		 1dfoB-4rhmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		5 LEU B 672
LEU B 668
VAL B 715
ALA B 554
SER B 598
 None
 1.11A 1dfoB-4wwxB:
undetectable		 1dfoB-4wwxB:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 LEU A 115
GLY A 118
LEU A 121
SER A 170
SER A 349
 None
None
CAC  A 502 (-4.7A)
CAC  A 502 ( 4.8A)
None
 1.11A 1dfoB-4wxbA:
60.3		 1dfoB-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		7 LEU A 115
GLY A 118
SER A 170
ALA A 171
ASN A 341
SER A 349
ARG A 357
 None
None
CAC  A 502 ( 4.8A)
None
None
None
CAC  A 502 (-3.1A)
 0.87A 1dfoB-4wxbA:
60.3		 1dfoB-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 LEU A 115
GLY A 119
ASN A 341
SER A 349
ARG A 357
 None
None
None
None
CAC  A 502 (-3.1A)
 1.09A 1dfoB-4wxbA:
60.3		 1dfoB-4wxbA:
58.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 LEU A 824
VAL A 723
ALA A 650
PHE A 783
ARG A 831
 None
 1.05A 1dfoB-4xqkA:
undetectable		 1dfoB-4xqkA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA

(Escherichia
coli) 		PF02917
(Pertussis_S1) 		5 LEU A  36
GLY A  38
LEU A  32
VAL A  95
SER A  40
 None
 1.05A 1dfoB-4z9cA:
undetectable		 1dfoB-4z9cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9d PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA

(Escherichia
coli) 		PF02917
(Pertussis_S1) 		5 LEU A  36
GLY A  38
LEU A  32
VAL A  95
SER A  40
 None
NAD  A 202 (-3.8A)
None
None
None
 1.10A 1dfoB-4z9dA:
undetectable		 1dfoB-4z9dA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 GLY A 417
LEU A  74
VAL A 118
ASN A 394
ARG A 415
 None
 1.05A 1dfoB-5cqfA:
undetectable		 1dfoB-5cqfA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		5 LEU A 368
GLY A 366
LEU A 128
ALA A 363
SER A 266
 None
None
None
None
ADP  A 501 (-2.9A)
 0.97A 1dfoB-5dm3A:
undetectable		 1dfoB-5dm3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT

(Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU B  95
GLY B  98
LEU B  91
VAL B  84
ASN B 112
 None
FAD  B 321 (-3.3A)
None
None
FAD  B 321 (-3.7A)
 1.11A 1dfoB-5g5gB:
undetectable		 1dfoB-5g5gB:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 GLY A 254
HIS A 199
LEU A 203
VAL A 246
PHE A 262
 None
 1.16A 1dfoB-5hkjA:
undetectable		 1dfoB-5hkjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 LEU A 915
GLY A 917
ALA A 920
ASN A 924
SER A 909
 None
 1.14A 1dfoB-5i6hA:
undetectable		 1dfoB-5i6hA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis) 		PF00079
(Serpin) 		5 LEU A 359
LEU A  91
VAL A  95
ALA A 115
PHE A 106
 None
 1.05A 1dfoB-5inwA:
undetectable		 1dfoB-5inwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU A 340
GLY A 338
LEU B1203
PRO B1197
PHE B1158
 None
 1.15A 1dfoB-5ip9A:
undetectable		 1dfoB-5ip9A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixd TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 LEU A 266
LEU A 195
ALA A 201
ASN A 252
SER A 259
 None
 1.14A 1dfoB-5ixdA:
undetectable		 1dfoB-5ixdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx0 DIPEPTIDASE

(Aspergillus
fumigatus) 		PF01244
(Peptidase_M19) 		5 LEU A 188
LEU A 192
ALA A 168
ASN A 165
SER A 142
 None
 1.06A 1dfoB-5lx0A:
undetectable		 1dfoB-5lx0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF03814
(KdpA)
PF02669
(KdpC) 		5 LEU A  69
LEU A 139
ALA A 146
SER C   9
PHE C  13
 None
 1.13A 1dfoB-5mrwA:
undetectable		 1dfoB-5mrwA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 7 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.53A 1dfoB-5v7iA:
51.9		 1dfoB-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		5 ALA A 173
ASN A 342
SER A 350
PHE A 352
ARG A 358
 None
 0.89A 1dfoB-5vc2A:
53.1		 1dfoB-5vc2A:
52.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		5 SER A 172
ALA A 173
ASN A 342
PHE A 352
ARG A 358
 None
 0.85A 1dfoB-5vc2A:
53.1		 1dfoB-5vc2A:
52.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 ALA A 176
ASN A 346
SER A 354
PRO A 355
ARG A 362
 None
 0.71A 1dfoB-5vmbA:
58.5		 1dfoB-5vmbA:
71.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 SER A 175
ALA A 176
ASN A 346
SER A 354
ARG A 362
 None
 0.74A 1dfoB-5vmbA:
58.5		 1dfoB-5vmbA:
71.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfo PHD FINGER PROTEIN 1

(Homo sapiens) 		PF00628
(PHD) 		5 LEU A 171
GLY A 173
LEU A 167
VAL A 236
ASN A 183
 None
 1.07A 1dfoB-5xfoA:
undetectable		 1dfoB-5xfoA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 7 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.66A 1dfoB-5xmrA:
56.4		 1dfoB-5xmrA:
40.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 LEU A  73
LEU A 191
VAL A 108
ALA A  42
PRO A 120
 None
 1.10A 1dfoB-5z06A:
undetectable		 1dfoB-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 5 HIS A 341
LEU A 345
SER A 339
PRO A 285
PHE A 283
 None
 1.05A 1dfoB-6byxA:
undetectable		 1dfoB-6byxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 9 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.64A 1dfoB-6cczA:
56.4		 1dfoB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 5 LEU A 204
GLY A 208
SER A 264
ASN A 439
ARG A 454
 None
None
ACT  A 612 (-2.7A)
None
ACT  A 612 (-2.9A)
 1.06A 1dfoB-6cczA:
56.4		 1dfoB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2x PROTEIN TYROSINE
KINASE A

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 221
GLY A 247
HIS A 251
LEU A 225
ALA A 249
 None
 1.12A 1dfoB-6f2xA:
undetectable		 1dfoB-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Synechocystis
sp. PCC 6803;
Deinococcus
radiodurans) 		no annotation 5 LEU A 498
LEU A 438
ALA A 339
SER A 347
PRO A 348
 None
 1.04A 1dfoB-6fhtA:
undetectable		 1dfoB-6fhtA:
undetectable