SIMILAR PATTERNS OF AMINO ACIDS FOR 1DFO_B_FFOB2002_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.75A 1dfoA-1cj0A:
51.0		 1dfoA-1cj0A:
45.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mec MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP1)

(Cardiovirus A) 		no annotation 4 TYR 1  37
TYR 1 242
PHE 1 120
PRO 1 119
 None
 1.16A 1dfoA-1mec1:
undetectable		 1dfoA-1mec1:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tme THEILER'S MURINE
ENCEPHALOMYELITIS
VIRUS (SUBUNIT VP1)

(Cardiovirus B) 		no annotation 4 TYR 1  37
TYR 1 238
PHE 1 120
PRO 1 119
 None
 1.15A 1dfoA-1tme1:
undetectable		 1dfoA-1tme1:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtm COAT PROTEIN

(Tobacco mild
green mosaic
virus) 		PF00721
(TMV_coat) 		4 TYR P  68
TYR P  70
PHE P  62
PRO P  63
 None
 1.33A 1dfoA-1vtmP:
undetectable		 1dfoA-1vtmP:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284

(Homo sapiens) 		PF00179
(UQ_con) 		4 GLU A  52
TYR A  49
PHE A  54
PRO A  79
 None
 1.31A 1dfoA-2a7lA:
undetectable		 1dfoA-2a7lA:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		5 GLU A  53
TYR A  60
TYR A  61
PHE A 252
PRO A 253
 None
 0.33A 1dfoA-2dkjA:
60.5		 1dfoA-2dkjA:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 GLU A 186
TYR A 215
TYR A 213
PRO A 192
 None
 1.45A 1dfoA-2v5dA:
undetectable		 1dfoA-2v5dA:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		4 GLU A  53
TYR A  51
PHE A 251
PRO A 252
 None
 1.38A 1dfoA-2vmxA:
61.2		 1dfoA-2vmxA:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		5 GLU A  53
TYR A  60
TYR A  61
PHE A 251
PRO A 252
 None
 0.41A 1dfoA-2vmxA:
61.2		 1dfoA-2vmxA:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 TYR A 408
TYR A  82
PHE A 399
PRO A 411
 None
 1.37A 1dfoA-2ykyA:
20.7		 1dfoA-2ykyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjq PHAGE-RELATED
PROTEIN

(Bordetella
bronchiseptica) 		PF03864
(Phage_cap_E) 		4 TYR A 264
TYR A 266
PHE A  49
PRO A 260
 None
 1.26A 1dfoA-3bjqA:
undetectable		 1dfoA-3bjqA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcd GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		4 GLU A 124
TYR A 115
PHE A 287
PRO A 254
 None
 1.18A 1dfoA-3dcdA:
undetectable		 1dfoA-3dcdA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.82A 1dfoA-3g8mA:
57.2		 1dfoA-3g8mA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 GLU A 210
TYR A 263
PHE A 214
PRO A 310
 None
 1.30A 1dfoA-3h2zA:
undetectable		 1dfoA-3h2zA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F

(Bacteroides
fragilis) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 GLU A 373
TYR A 280
PHE A 311
PRO A 313
 EDO  A 420 ( 3.5A)
None
EDO  A 418 ( 4.4A)
EDO  A 420 (-4.5A)
 1.02A 1dfoA-3ks7A:
undetectable		 1dfoA-3ks7A:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 GLU A  52
TYR A  50
PHE A 250
PRO A 251
 None
 1.28A 1dfoA-3n0lA:
57.1		 1dfoA-3n0lA:
55.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 GLU A  52
TYR A  59
PHE A 250
PRO A 251
 None
 0.60A 1dfoA-3n0lA:
57.1		 1dfoA-3n0lA:
55.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 GLU A  52
TYR A  59
TYR A  60
PHE A 250
 None
 1.00A 1dfoA-3n0lA:
57.1		 1dfoA-3n0lA:
55.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		4 GLU A  53
TYR A  51
PHE A 251
PRO A 252
 None
 1.02A 1dfoA-3pgyA:
56.4		 1dfoA-3pgyA:
58.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zul FLUORESCENT PROTEIN
DRONPA

(Echinophyllia
sp. SC22) 		PF01353
(GFP) 		4 TYR A 114
TYR A 116
PHE A  68
PRO A  33
 None
GYC  A  63 ( 4.8A)
None
None
 1.48A 1dfoA-3zulA:
undetectable		 1dfoA-3zulA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		4 TYR A 394
TYR A  69
PHE A 385
PRO A 397
 None
 1.34A 1dfoA-4aoaA:
21.1		 1dfoA-4aoaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 GLU A 136
TYR A 133
TYR A 132
PRO A 431
 None
 1.38A 1dfoA-4arcA:
undetectable		 1dfoA-4arcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 TYR A 457
TYR A 164
PHE A 407
PRO A 414
 None
 1.24A 1dfoA-4ckbA:
undetectable		 1dfoA-4ckbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE

(Bacillus
anthracis) 		PF07992
(Pyr_redox_2) 		4 GLU C 114
TYR C 126
PHE C 231
PRO C 275
 FAD  C 500 (-3.7A)
FAD  C 500 (-4.3A)
None
None
 1.26A 1dfoA-4fk1C:
undetectable		 1dfoA-4fk1C:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		4 GLU A  57
TYR A  65
PHE A 256
PRO A 257
 None
 0.40A 1dfoA-4j5uA:
59.7		 1dfoA-4j5uA:
56.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		4 GLU A  56
TYR A  63
PHE A 266
PRO A 267
 None
 0.65A 1dfoA-4o6zA:
52.5		 1dfoA-4o6zA:
38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		4 GLU A  56
TYR A  63
TYR A  64
PHE A 266
 None
 0.85A 1dfoA-4o6zA:
52.5		 1dfoA-4o6zA:
38.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE

(Nicotiana
tabacum) 		PF00145
(DNA_methylase) 		4 GLU A 294
TYR A 293
TYR A 333
PRO A 566
 None
 1.43A 1dfoA-4onqA:
undetectable		 1dfoA-4onqA:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		4 GLU A  57
TYR A  55
PHE A 257
PRO A 258
 None
SO4  A 503 (-4.3A)
None
None
 1.49A 1dfoA-4p3mA:
51.2		 1dfoA-4p3mA:
74.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
 None
 0.46A 1dfoA-4p3mA:
51.2		 1dfoA-4p3mA:
74.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p79 CLAUDIN-15

(Mus musculus) 		PF00822
(PMP22_Claudin) 		4 GLU A  46
TYR A 156
PHE A  65
PRO A  66
 None
 1.33A 1dfoA-4p79A:
undetectable		 1dfoA-4p79A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLU A  28
TYR A  26
PHE A  30
PRO A 210
 None
 1.32A 1dfoA-4px1A:
undetectable		 1dfoA-4px1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 GLU A 374
TYR A 281
PHE A 312
PRO A 314
 None
 1.05A 1dfoA-4qhbA:
undetectable		 1dfoA-4qhbA:
22.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 GLU A  51
TYR A  58
TYR A  59
PHE A 250
PRO A 251
 None
 0.77A 1dfoA-4wxbA:
58.5		 1dfoA-4wxbA:
58.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 GLU A 186
TYR A 215
TYR A 213
PRO A 192
 None
 1.35A 1dfoA-4zxlA:
undetectable		 1dfoA-4zxlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f HUMAN SAFFOLD
VIRUS-3 VP1

(Cardiovirus B) 		no annotation 4 TYR A  37
TYR A 243
PHE A 122
PRO A 121
 None
 1.18A 1dfoA-5a8fA:
undetectable		 1dfoA-5a8fA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfc VP1

(Cardiovirus B) 		no annotation 4 TYR A  37
TYR A 243
PHE A 122
PRO A 121
 None
 1.18A 1dfoA-5cfcA:
undetectable		 1dfoA-5cfcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 GLU A 473
TYR A 477
PHE A 463
PRO A 462
 None
None
HEM  A 601 (-4.4A)
None
 1.16A 1dfoA-5hs1A:
undetectable		 1dfoA-5hs1A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 GLU A  98
TYR A 105
TYR A 106
PHE A 320
PRO A 321
 None
 0.73A 1dfoA-5v7iA:
51.5		 1dfoA-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 GLU A  56
TYR A  63
TYR A  64
PHE A 256
PRO A 257
 None
 0.86A 1dfoA-5vmbA:
58.1		 1dfoA-5vmbA:
71.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 GLU B 734
TYR B 714
TYR B 716
PHE B1048
 None
 1.44A 1dfoA-5vniB:
undetectable		 1dfoA-5vniB:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 5 GLU A  56
TYR A  63
TYR A  64
PHE A 266
PRO A 267
 None
 0.63A 1dfoA-5xmrA:
53.7		 1dfoA-5xmrA:
40.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 GLU A 136
TYR A 134
PHE A 349
PRO A 350
 None
None
None
SEY  A 607 (-4.7A)
 1.46A 1dfoA-6cczA:
54.4		 1dfoA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.26A 1dfoA-6cczA:
54.4		 1dfoA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exp SIRV3 ACRID1 (GP02)
ANTI-CRISPR PROTEIN

(Sulfolobus
islandicus
rudivirus 3) 		no annotation 4 GLU A  58
TYR A  76
PHE A  60
PRO A  46
 None
 1.10A 1dfoA-6expA:
undetectable		 1dfoA-6expA:
undetectable