SIMILAR PATTERNS OF AMINO ACIDS FOR 1DFO_A_FFOA1002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)


(Oryctolagus
cuniculus)
PF00464
(SHMT)
5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
None
0.74A 1dfoB-1cj0A:
51.5
1dfoB-1cj0A:
45.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mec MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP1)


(Cardiovirus A)
no annotation 4 TYR 1  37
TYR 1 242
PHE 1 120
PRO 1 119
None
1.16A 1dfoB-1mec1:
undetectable
1dfoB-1mec1:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tme THEILER'S MURINE
ENCEPHALOMYELITIS
VIRUS (SUBUNIT VP1)


(Cardiovirus B)
no annotation 4 TYR 1  37
TYR 1 238
PHE 1 120
PRO 1 119
None
1.15A 1dfoB-1tme1:
undetectable
1dfoB-1tme1:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtm COAT PROTEIN

(Tobacco mild
green mosaic
virus)
PF00721
(TMV_coat)
4 TYR P  68
TYR P  70
PHE P  62
PRO P  63
None
1.33A 1dfoB-1vtmP:
undetectable
1dfoB-1vtmP:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284


(Homo sapiens)
PF00179
(UQ_con)
4 GLU A  52
TYR A  49
PHE A  54
PRO A  79
None
1.31A 1dfoB-2a7lA:
undetectable
1dfoB-2a7lA:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE


(Thermus
thermophilus)
PF00464
(SHMT)
5 GLU A  53
TYR A  60
TYR A  61
PHE A 252
PRO A 253
None
0.33A 1dfoB-2dkjA:
61.9
1dfoB-2dkjA:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 GLU A 766
TYR A 340
TYR A 712
PHE A 330
None
1.50A 1dfoB-2iujA:
undetectable
1dfoB-2iujA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1


(Mus musculus)
PF04099
(Sybindin)
4 GLU C  75
TYR C  74
TYR C  73
PRO C  77
None
1.22A 1dfoB-2j3tC:
undetectable
1dfoB-2j3tC:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase)
4 GLU A 186
TYR A 215
TYR A 213
PRO A 192
None
1.45A 1dfoB-2v5dA:
undetectable
1dfoB-2v5dA:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE


(Geobacillus
stearothermophilus)
PF00464
(SHMT)
4 GLU A  53
TYR A  51
PHE A 251
PRO A 252
None
1.38A 1dfoB-2vmxA:
62.3
1dfoB-2vmxA:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE


(Geobacillus
stearothermophilus)
PF00464
(SHMT)
5 GLU A  53
TYR A  60
TYR A  61
PHE A 251
PRO A 252
None
0.41A 1dfoB-2vmxA:
62.3
1dfoB-2vmxA:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK)
PF00202
(Aminotran_3)
4 TYR A 408
TYR A  82
PHE A 399
PRO A 411
None
1.37A 1dfoB-2ykyA:
21.7
1dfoB-2ykyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjq PHAGE-RELATED
PROTEIN


(Bordetella
bronchiseptica)
PF03864
(Phage_cap_E)
4 TYR A 264
TYR A 266
PHE A  49
PRO A 260
None
1.27A 1dfoB-3bjqA:
undetectable
1dfoB-3bjqA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcd GALACTOSE MUTAROTASE
RELATED ENZYME


(Lactobacillus
acidophilus)
PF01263
(Aldose_epim)
4 GLU A 124
TYR A 115
PHE A 287
PRO A 254
None
1.18A 1dfoB-3dcdA:
undetectable
1dfoB-3dcdA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE


(Escherichia
coli)
PF00464
(SHMT)
5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
None
0.82A 1dfoB-3g8mA:
58.1
1dfoB-3g8mA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE


(Shigella
flexneri)
PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C)
4 GLU A 210
TYR A 263
PHE A 214
PRO A 310
None
1.31A 1dfoB-3h2zA:
undetectable
1dfoB-3h2zA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F


(Bacteroides
fragilis)
PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C)
4 GLU A 373
TYR A 280
PHE A 311
PRO A 313
EDO  A 420 ( 3.5A)
None
EDO  A 418 ( 4.4A)
EDO  A 420 (-4.5A)
1.02A 1dfoB-3ks7A:
undetectable
1dfoB-3ks7A:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE


(Campylobacter
jejuni)
PF00464
(SHMT)
4 GLU A  52
TYR A  50
PHE A 250
PRO A 251
None
1.28A 1dfoB-3n0lA:
57.6
1dfoB-3n0lA:
55.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE


(Campylobacter
jejuni)
PF00464
(SHMT)
4 GLU A  52
TYR A  59
PHE A 250
PRO A 251
None
0.60A 1dfoB-3n0lA:
57.6
1dfoB-3n0lA:
55.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE


(Staphylococcus
aureus)
PF00464
(SHMT)
4 GLU A  53
TYR A  51
PHE A 251
PRO A 252
None
1.02A 1dfoB-3pgyA:
57.3
1dfoB-3pgyA:
58.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zul FLUORESCENT PROTEIN
DRONPA


(Echinophyllia
sp. SC22)
PF01353
(GFP)
4 TYR A 114
TYR A 116
PHE A  68
PRO A  33
None
GYC  A  63 ( 4.8A)
None
None
1.48A 1dfoB-3zulA:
undetectable
1dfoB-3zulA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE


(Variovorax
paradoxus)
PF00202
(Aminotran_3)
4 TYR A 394
TYR A  69
PHE A 385
PRO A 397
None
1.35A 1dfoB-4aoaA:
21.9
1dfoB-4aoaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
4 GLU A 136
TYR A 133
TYR A 132
PRO A 431
None
1.38A 1dfoB-4arcA:
undetectable
1dfoB-4arcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT


(Vaccinia virus)
PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT)
4 TYR A 457
TYR A 164
PHE A 407
PRO A 414
None
1.23A 1dfoB-4ckbA:
undetectable
1dfoB-4ckbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE


(Bacillus
anthracis)
PF07992
(Pyr_redox_2)
4 GLU C 114
TYR C 126
PHE C 231
PRO C 275
FAD  C 500 (-3.7A)
FAD  C 500 (-4.3A)
None
None
1.26A 1dfoB-4fk1C:
undetectable
1dfoB-4fk1C:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE


(Rickettsia
rickettsii)
PF00464
(SHMT)
4 GLU A  57
TYR A  65
PHE A 256
PRO A 257
None
0.40A 1dfoB-4j5uA:
60.9
1dfoB-4j5uA:
56.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3o PUTATIVE
D-GLYCERO-D-MANNO-HE
PTOSE 7-PHOSPHATE
KINASE


(Campylobacter
jejuni)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
4 GLU A 173
TYR A  31
TYR A  28
PHE A 171
None
1.23A 1dfoB-4n3oA:
undetectable
1dfoB-4n3oA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE


(Plasmodium
falciparum)
PF00464
(SHMT)
4 GLU A  56
TYR A  63
PHE A 266
PRO A 267
None
0.64A 1dfoB-4o6zA:
55.1
1dfoB-4o6zA:
38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE


(Plasmodium
falciparum)
PF00464
(SHMT)
4 GLU A  56
TYR A  63
TYR A  64
PHE A 266
None
0.85A 1dfoB-4o6zA:
55.1
1dfoB-4o6zA:
38.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE


(Nicotiana
tabacum)
PF00145
(DNA_methylase)
4 GLU A 294
TYR A 293
TYR A 333
PRO A 566
None
1.43A 1dfoB-4onqA:
undetectable
1dfoB-4onqA:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE


(Psychromonas
ingrahamii)
PF00464
(SHMT)
4 GLU A  57
TYR A  55
PHE A 257
PRO A 258
None
SO4  A 503 (-4.3A)
None
None
1.49A 1dfoB-4p3mA:
51.2
1dfoB-4p3mA:
74.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE


(Psychromonas
ingrahamii)
PF00464
(SHMT)
5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
None
0.46A 1dfoB-4p3mA:
51.2
1dfoB-4p3mA:
74.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p79 CLAUDIN-15

(Mus musculus)
PF00822
(PMP22_Claudin)
4 GLU A  46
TYR A 156
PHE A  65
PRO A  66
None
1.32A 1dfoB-4p79A:
undetectable
1dfoB-4p79A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)


(Methylobacterium
extorquens)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 GLU A  28
TYR A  26
PHE A  30
PRO A 210
None
1.33A 1dfoB-4px1A:
undetectable
1dfoB-4px1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN


(Bacteroides
vulgatus)
PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C)
4 GLU A 374
TYR A 281
PHE A 312
PRO A 314
None
1.06A 1dfoB-4qhbA:
undetectable
1dfoB-4qhbA:
22.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE


(Streptococcus
thermophilus)
PF00464
(SHMT)
5 GLU A  51
TYR A  58
TYR A  59
PHE A 250
PRO A 251
None
0.77A 1dfoB-4wxbA:
60.3
1dfoB-4wxbA:
58.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase)
4 GLU A 186
TYR A 215
TYR A 213
PRO A 192
None
1.36A 1dfoB-4zxlA:
undetectable
1dfoB-4zxlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f HUMAN SAFFOLD
VIRUS-3 VP1


(Cardiovirus B)
no annotation 4 TYR A  37
TYR A 243
PHE A 122
PRO A 121
None
1.18A 1dfoB-5a8fA:
undetectable
1dfoB-5a8fA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfc VP1

(Cardiovirus B)
no annotation 4 TYR A  37
TYR A 243
PHE A 122
PRO A 121
None
1.18A 1dfoB-5cfcA:
undetectable
1dfoB-5cfcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
4 GLU A 473
TYR A 477
PHE A 463
PRO A 462
None
None
HEM  A 601 (-4.4A)
None
1.16A 1dfoB-5hs1A:
undetectable
1dfoB-5hs1A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL


(Homo sapiens)
no annotation 5 GLU A  98
TYR A 105
TYR A 106
PHE A 320
PRO A 321
None
0.72A 1dfoB-5v7iA:
51.9
1dfoB-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE


(Acinetobacter
baumannii)
PF00464
(SHMT)
5 GLU A  56
TYR A  63
TYR A  64
PHE A 256
PRO A 257
None
0.85A 1dfoB-5vmbA:
58.5
1dfoB-5vmbA:
71.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A


(Homo sapiens)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
4 GLU B 734
TYR B 714
TYR B 716
PHE B1048
None
1.44A 1dfoB-5vniB:
undetectable
1dfoB-5vniB:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE


(Plasmodium
vivax)
no annotation 5 GLU A  56
TYR A  63
TYR A  64
PHE A 266
PRO A 267
None
0.63A 1dfoB-5xmrA:
56.4
1dfoB-5xmrA:
40.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE


(Medicago
truncatula)
no annotation 4 GLU A 136
TYR A 134
PHE A 349
PRO A 350
None
None
None
SEY  A 607 (-4.7A)
1.46A 1dfoB-6cczA:
56.4
1dfoB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE


(Medicago
truncatula)
no annotation 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
None
None
None
None
SEY  A 607 (-4.7A)
0.27A 1dfoB-6cczA:
56.4
1dfoB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exp SIRV3 ACRID1 (GP02)
ANTI-CRISPR PROTEIN


(Sulfolobus
islandicus
rudivirus 3)
no annotation 4 GLU A  58
TYR A  76
PHE A  60
PRO A  46
None
1.10A 1dfoB-6expA:
undetectable
1dfoB-6expA:
undetectable