SIMILAR PATTERNS OF AMINO ACIDS FOR 1DB1_A_VDXA428_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 LEU S 872
SER S 876
VAL S 927
LEU S 795
HIS S 827
 None
 1.34A 1db1A-1bkdS:
undetectable		 1db1A-1bkdS:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A  47
LEU A  50
VAL A  51
SER A 111
VAL A 392
 None
 1.30A 1db1A-1cg2A:
0.2		 1db1A-1cg2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		5 LEU A 326
LEU A 329
VAL A 330
SER A 332
LEU A 344
 None
 1.32A 1db1A-1f0iA:
0.0		 1db1A-1f0iA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 LEU A 521
LEU A 522
VAL A 518
VAL A 204
LEU A 273
 None
 1.12A 1db1A-1lnsA:
0.0		 1db1A-1lnsA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 LEU A 142
LEU A 139
VAL A 138
SER A  99
CYH A  92
 None
 1.16A 1db1A-1nfgA:
0.0		 1db1A-1nfgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		5 LEU A 205
SER A 198
SER A  92
LEU A  49
HIS A  61
 None
 1.29A 1db1A-1sqhA:
0.0		 1db1A-1sqhA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 TYR A 661
LEU A  18
SER A  91
VAL A 169
LEU A 236
 None
 1.34A 1db1A-1urjA:
0.0		 1db1A-1urjA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		5 LEU A 872
SER A 876
VAL A 927
LEU A 795
HIS A 827
 None
 1.34A 1db1A-1xdvA:
1.1		 1db1A-1xdvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]

(Yellow fever
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		5 LEU A 540
LEU A 546
CYH A 567
VAL A 536
LEU A 529
 None
 1.35A 1db1A-1yksA:
0.0		 1db1A-1yksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		5 TYR A 743
LEU A 530
VAL A 534
SER A 536
VAL A 505
 None
 1.30A 1db1A-1z26A:
undetectable		 1db1A-1z26A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		5 LEU A 363
LEU A 360
SER A  69
VAL A 349
LEU A 304
 None
 1.22A 1db1A-1zkdA:
undetectable		 1db1A-1zkdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		5 LEU A 363
LEU A 360
VAL A 361
SER A  69
VAL A 349
 None
 1.11A 1db1A-1zkdA:
undetectable		 1db1A-1zkdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 LEU B  70
LEU B  67
VAL B  66
SER B  63
HIS B  94
 HEM  B 200 (-3.8A)
None
HEM  B 200 ( 3.9A)
None
HEM  B 200 (-3.2A)
 1.10A 1db1A-2d2nB:
undetectable		 1db1A-2d2nB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 1.08A 1db1A-2h21A:
undetectable		 1db1A-2h21A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwx TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF13638
(PIN_4) 		5 LEU A1273
LEU A1266
SER A1320
VAL A1275
LEU A1283
 None
 1.24A 1db1A-2hwxA:
undetectable		 1db1A-2hwxA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		12 TYR A 143
LEU A 226
LEU A 229
VAL A 230
SER A 233
SER A 271
SER A 274
CYH A 284
VAL A 296
HIS A 301
LEU A 305
HIS A 393
 VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.5A)
VD4  A 500 ( 4.8A)
VD4  A 500 ( 4.6A)
VD4  A 500 ( 2.8A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 2.9A)
VD4  A 500 ( 3.4A)
VD4  A 500 ( 4.4A)
VD4  A 500 ( 3.9A)
None
VD4  A 500 ( 3.9A)
 0.30A 1db1A-2o4jA:
38.4		 1db1A-2o4jA:
90.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A  67
LEU A  76
SER A  85
VAL A 105
LEU A 114
 None
 1.36A 1db1A-2oaeA:
undetectable		 1db1A-2oaeA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm6 GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 LEU B 466
VAL B 468
SER B 384
SER B 560
VAL B 487
 None
 1.34A 1db1A-2qm6B:
undetectable		 1db1A-2qm6B:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A  20
LEU A 335
SER A 208
VAL A  15
LEU A 129
 None
 1.34A 1db1A-2qveA:
undetectable		 1db1A-2qveA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qww TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Listeria
monocytogenes) 		PF12802
(MarR_2) 		5 LEU A  83
VAL A  84
SER A 103
SER A 110
LEU A  64
 None
 1.14A 1db1A-2qwwA:
undetectable		 1db1A-2qwwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 TYR A 286
LEU A 253
VAL A 204
SER A 203
VAL A 249
 None
 1.36A 1db1A-2qytA:
undetectable		 1db1A-2qytA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		5 TYR A 243
LEU A 311
SER A 269
VAL A 309
LEU A  27
 None
 1.36A 1db1A-2qzpA:
undetectable		 1db1A-2qzpA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9y ALPHA-2-ANTIPLASMIN

(Mus musculus) 		PF00079
(Serpin) 		5 LEU A  66
LEU A  69
VAL A  70
VAL A  86
HIS A 353
 None
 1.29A 1db1A-2r9yA:
undetectable		 1db1A-2r9yA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS

(Fasciola
hepatica) 		PF14497
(GST_C_3) 		5 TYR A  93
LEU A 135
LEU A 138
VAL A 139
SER A 142
 DMS  A1212 ( 4.7A)
None
None
None
None
 1.04A 1db1A-2wduA:
undetectable		 1db1A-2wduA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 LEU A 158
LEU A 155
VAL A 152
SER A 149
LEU A 431
 None
 1.35A 1db1A-2z23A:
undetectable		 1db1A-2z23A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 SER A 272
SER A 231
SER A 198
HIS A 136
HIS A 134
 None
None
None
CU  A 701 (-3.2A)
CU  A 702 (-3.1A)
 1.25A 1db1A-3abgA:
undetectable		 1db1A-3abgA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 VAL A 265
SER A 264
SER A 200
VAL A 192
LEU A 176
 None
 1.23A 1db1A-3b05A:
undetectable		 1db1A-3b05A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		5 LEU A 593
LEU A 597
SER A 511
VAL A 564
LEU A 517
 None
None
CIT  A2000 (-4.1A)
None
None
 1.33A 1db1A-3bdlA:
undetectable		 1db1A-3bdlA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		5 LEU A 221
LEU A 224
VAL A 225
SER A 227
LEU A 145
 None
 1.12A 1db1A-3cg1A:
undetectable		 1db1A-3cg1A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		5 LEU A 216
LEU A 219
VAL A 220
SER A 222
LEU A 140
 None
 1.05A 1db1A-3cg3A:
undetectable		 1db1A-3cg3A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		5 LEU A 221
LEU A 224
VAL A 225
SER A 227
LEU A 138
 None
 1.10A 1db1A-3cijA:
undetectable		 1db1A-3cijA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e29 UNCHARACTERIZED
PROTEIN Q7WE92_BORBR

(Bordetella
bronchiseptica) 		PF03061
(4HBT) 		5 LEU A  58
LEU A  61
VAL A  62
VAL A 124
HIS A  88
 None
 1.27A 1db1A-3e29A:
undetectable		 1db1A-3e29A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec1 YQEH GTPASE

(Geobacillus
stearothermophilus) 		PF01926
(MMR_HSR1) 		5 LEU A 326
LEU A 352
VAL A 353
CYH A 345
VAL A 362
 None
 1.33A 1db1A-3ec1A:
undetectable		 1db1A-3ec1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 TYR A 575
LEU A 463
SER A 580
HIS A 637
LEU A 640
 None
 1.25A 1db1A-3fedA:
undetectable		 1db1A-3fedA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk4 ZONA PELLUCIDA 3

(Gallus gallus) 		PF00100
(Zona_pellucida)
no annotation 		5 LEU A 297
LEU A 224
VAL A 299
SER A 215
VAL C 372
 None
 1.30A 1db1A-3nk4A:
undetectable		 1db1A-3nk4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o01 CELL INVASION
PROTEIN SIPD

(Salmonella
enterica) 		PF06511
(IpaD) 		5 LEU A  87
LEU A  90
SER A  93
SER A 333
VAL A 138
 None
 1.01A 1db1A-3o01A:
undetectable		 1db1A-3o01A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 LEU A 324
VAL A 296
SER A 342
CYH A 354
VAL A 318
 None
 1.23A 1db1A-3of7A:
undetectable		 1db1A-3of7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A  35
LEU A  38
VAL A  39
SER A  42
LEU A  96
 None
 1.25A 1db1A-3pkjA:
undetectable		 1db1A-3pkjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 112
LEU A 216
SER A 205
VAL A 108
LEU A 133
 None
None
None
None
FAD  A 499 (-4.0A)
 1.33A 1db1A-3popA:
undetectable		 1db1A-3popA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3siv NHP2-LIKE PROTEIN 1

(Homo sapiens) 		PF01248
(Ribosomal_L7Ae) 		5 LEU A  22
LEU A  25
VAL A  26
SER A  29
VAL A  81
 None
 1.09A 1db1A-3sivA:
undetectable		 1db1A-3sivA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		5 LEU A 313
LEU A 188
VAL A 187
VAL A 473
LEU A 486
 None
 1.29A 1db1A-3t5oA:
undetectable		 1db1A-3t5oA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 5 LEU B 818
LEU B 907
VAL B 816
SER B 815
VAL B 854
 None
 1.11A 1db1A-3tixB:
undetectable		 1db1A-3tixB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 LEU A1212
LEU A1209
VAL A1203
SER A1240
VAL A1247
 None
 1.28A 1db1A-3ummA:
undetectable		 1db1A-3ummA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyj LYSINE-SPECIFIC
DEMETHYLASE 8

(Homo sapiens) 		PF13621
(Cupin_8) 		5 TYR A 272
LEU A 392
LEU A 329
SER A 410
SER A 318
 AKG  A 601 (-4.7A)
None
AKG  A 601 ( 4.4A)
AKG  A 601 ( 4.7A)
AKG  A 601 (-2.6A)
 1.18A 1db1A-3uyjA:
undetectable		 1db1A-3uyjA:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 233
SER A 237
SER A 278
CYH A 288
LEU A 393
 ED9  A 501 ( 4.3A)
ED9  A 501 (-2.7A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
None
 1.27A 1db1A-3wgpA:
42.0		 1db1A-3wgpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 TYR A 143
LEU A 230
LEU A 233
VAL A 234
SER A 237
SER A 275
SER A 278
CYH A 288
VAL A 300
HIS A 305
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.6A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.19A 1db1A-3wgpA:
42.0		 1db1A-3wgpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		5 LEU A 196
SER A 120
VAL A 228
LEU A 254
HIS A 253
 None
 1.29A 1db1A-3wy7A:
undetectable		 1db1A-3wy7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A  35
LEU A  38
VAL A  39
SER A  42
LEU A  96
 None
 1.25A 1db1A-3zg6A:
undetectable		 1db1A-3zg6A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 LEU A  14
VAL A 108
VAL A  78
HIS A  79
LEU A  74
 None
None
None
None
JLN  A1528 (-4.1A)
 1.07A 1db1A-4a1oA:
undetectable		 1db1A-4a1oA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 5 VAL A 225
SER A 198
SER A 159
CYH A 163
VAL A 246
 None
 1.35A 1db1A-4czxA:
undetectable		 1db1A-4czxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew9 PECTATE LYASE

(Caldicellulosiruptor
bescii) 		PF03211
(Pectate_lyase) 		5 LEU A  53
LEU A  47
VAL A  14
VAL A  56
LEU A   6
 None
None
None
None
MPD  A 207 ( 3.8A)
 1.35A 1db1A-4ew9A:
undetectable		 1db1A-4ew9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 LEU B 628
LEU B 631
VAL B 632
CYH B 588
LEU B 500
 None
 1.29A 1db1A-4f92B:
undetectable		 1db1A-4f92B:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 TYR A 324
LEU A 122
LEU A 116
VAL A 119
VAL A 125
 None
 1.26A 1db1A-4gqoA:
undetectable		 1db1A-4gqoA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF15414
(DUF4621) 		5 LEU A 116
LEU A 223
SER A  62
VAL A 186
HIS A 120
 None
 1.22A 1db1A-4h3wA:
undetectable		 1db1A-4h3wA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  27
LEU A  29
VAL A  31
SER A  71
LEU A 103
 None
 1.15A 1db1A-4je3A:
undetectable		 1db1A-4je3A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A  69
LEU A  65
SER A 180
SER A  86
VAL A  80
 None
None
None
EDO  A 403 (-2.8A)
None
 1.27A 1db1A-4lc3A:
undetectable		 1db1A-4lc3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqj HEMOGLOBIN SUBUNIT
GAMMA-2

(Homo sapiens) 		PF00042
(Globin) 		5 LEU B  71
LEU B  68
VAL B  67
VAL B 137
HIS B  92
 HEM  B 201 ( 4.6A)
None
HEM  B 201 ( 3.8A)
None
HEM  B 201 (-3.3A)
 1.23A 1db1A-4mqjB:
undetectable		 1db1A-4mqjB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU A 350
LEU A 347
VAL A 346
SER A 343
SER A 377
 None
 1.29A 1db1A-4mx2A:
undetectable		 1db1A-4mx2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbo STEROID RECEPTOR RNA
ACTIVATOR 1

(Homo sapiens) 		PF07304
(SRA1) 		5 LEU A 118
LEU A 115
VAL A 114
VAL A 198
LEU A 183
 None
 1.32A 1db1A-4nboA:
undetectable		 1db1A-4nboA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 142
LEU A 146
VAL A 188
SER A 162
VAL A 100
 None
 1.20A 1db1A-4px1A:
undetectable		 1db1A-4px1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 LEU A 904
LEU A 900
VAL A 903
SER A 920
VAL A 933
 None
 1.28A 1db1A-4q73A:
undetectable		 1db1A-4q73A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus) 		PF01546
(Peptidase_M20) 		5 LEU A 168
LEU A 239
VAL A 166
CYH A 201
VAL A 263
 None
 1.31A 1db1A-4q7aA:
undetectable		 1db1A-4q7aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 169
LEU A 172
VAL A 173
VAL A 217
LEU A 269
 None
 1.17A 1db1A-4roeA:
undetectable		 1db1A-4roeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		5 LEU A 175
LEU A 178
VAL A 179
SER A 181
LEU A 250
 None
 1.28A 1db1A-4s38A:
undetectable		 1db1A-4s38A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.17A 1db1A-4uucA:
undetectable		 1db1A-4uucA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4we6 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A  68
LEU A  71
VAL A  72
SER A  75
LEU A 111
 None
 1.34A 1db1A-4we6A:
undetectable		 1db1A-4we6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0b DOUBLE CLP-N MOTIF
PROTEIN

(Arabidopsis
thaliana) 		PF02861
(Clp_N) 		5 VAL A 221
SER A 224
SER A 124
VAL A 135
LEU A 115
 None
 1.31A 1db1A-4y0bA:
undetectable		 1db1A-4y0bA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		5 LEU A 360
SER A 339
SER A 338
CYH A 217
HIS A 363
 None
 1.27A 1db1A-4z43A:
undetectable		 1db1A-4z43A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpk GAMMA-GLUTAMYLTRANSP
EPTIDASE (GGT)

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 LEU C 466
VAL C 468
SER C 384
SER C 560
VAL C 487
 None
None
None
EDO  C 705 (-2.7A)
None
 1.31A 1db1A-5bpkC:
undetectable		 1db1A-5bpkC:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwu NUCLEOPORIN NUP188

(Chaetomium
thermophilum) 		no annotation 5 LEU A1647
LEU A1646
SER A1632
VAL A1703
LEU A1757
 None
 1.31A 1db1A-5cwuA:
undetectable		 1db1A-5cwuA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dy1 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		5 LEU A  71
VAL A  75
SER A  78
VAL A 123
HIS A 132
 None
 1.34A 1db1A-5dy1A:
undetectable		 1db1A-5dy1A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL34 PROTEIN

(Suid
alphaherpesvirus
1) 		PF04541
(Herpes_U34) 		5 LEU B  81
VAL B  80
SER B  79
SER B  21
VAL B  71
 None
 1.12A 1db1A-5e8cB:
undetectable		 1db1A-5e8cB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 LEU D 377
LEU D 420
VAL D 421
SER D 416
LEU D 574
 None
 1.25A 1db1A-5exrD:
undetectable		 1db1A-5exrD:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASD

(Escherichia
coli) 		PF09704
(Cas_Cas5d) 		5 LEU J 120
LEU J   7
VAL J 118
CYH J  43
VAL J  61
 None
 1.32A 1db1A-5h9fJ:
undetectable		 1db1A-5h9fJ:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		5 LEU A 377
SER A 356
SER A 355
CYH A 233
HIS A 380
 None
 1.20A 1db1A-5hy5A:
undetectable		 1db1A-5hy5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 LEU A 645
LEU A 652
VAL A 653
SER A 656
VAL A 545
 None
 1.17A 1db1A-5iy9A:
undetectable		 1db1A-5iy9A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 5 LEU B 338
SER B 363
SER B 358
HIS B 729
LEU B 683
 None
 1.33A 1db1A-5iz5B:
undetectable		 1db1A-5iz5B:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jx3 URACIL-DNA
GLYCOSYLASE

(Vaccinia virus) 		no annotation 5 LEU A 170
VAL A 152
HIS A 151
LEU A  57
HIS A 147
 None
 1.24A 1db1A-5jx3A:
undetectable		 1db1A-5jx3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 LEU A 489
LEU A 492
SER A 495
VAL A   8
HIS A  27
 None
 1.34A 1db1A-5laeA:
undetectable		 1db1A-5laeA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb7 KATANIN P80 WD40
REPEAT-CONTAINING
SUBUNIT B1

(Mus musculus) 		PF13925
(Katanin_con80) 		5 LEU A 570
LEU A 632
VAL A 633
SER A 635
VAL A 578
 None
 1.32A 1db1A-5lb7A:
undetectable		 1db1A-5lb7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17

(Homo sapiens) 		PF00293
(NUDIX) 		5 LEU A  93
LEU A 184
VAL A  95
CYH A  40
VAL A   4
 None
None
None
EMC  A 402 (-2.6A)
None
 1.35A 1db1A-5lf8A:
undetectable		 1db1A-5lf8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mll DNA PROCESSING CHAIN
A (DPRA)

(Helicobacter
pylori) 		no annotation 5 LEU A 179
LEU A 195
SER A 167
SER A 163
VAL A 154
 None
 1.35A 1db1A-5mllA:
undetectable		 1db1A-5mllA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 LEU A 720
LEU A 701
SER A 687
SER A 690
VAL A 738
 None
None
None
CA  A9017 (-4.8A)
None
 1.27A 1db1A-5n8pA:
undetectable		 1db1A-5n8pA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 LEU A 720
LEU A 701
SER A 687
SER A 690
VAL A 738
 None
None
None
CA  A9017 (-4.8A)
None
 1.27A 1db1A-5n97A:
undetectable		 1db1A-5n97A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A2040
LEU A2043
SER A2047
LEU A1956
HIS A1954
 None
None
None
None
GOL  A2302 (-3.9A)
 1.07A 1db1A-5nnnA:
undetectable		 1db1A-5nnnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 LEU A1065
SER A1077
SER A1080
VAL A1152
HIS A1112
 None
 1.08A 1db1A-5u1sA:
undetectable		 1db1A-5u1sA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4t PUTATIVE GENTAMICIN
METHYLTRANSFERASE

(Micromonospora
echinospora) 		no annotation 5 LEU A 141
VAL A 140
SER A 134
SER A 161
VAL A 192
 None
None
SAH  A 414 ( 4.4A)
None
None
 1.34A 1db1A-5u4tA:
undetectable		 1db1A-5u4tA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A1243
LEU A1246
VAL A1247
SER A1250
VAL A1205
 None
 1.16A 1db1A-5ujaA:
undetectable		 1db1A-5ujaA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v76 MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		no annotation 5 LEU A  37
VAL A  36
SER A  35
SER A  24
VAL A  46
 None
 1.09A 1db1A-5v76A:
undetectable		 1db1A-5v76A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 5 LEU A 508
SER A 473
SER A 458
SER A 428
LEU A 502
 None
 1.33A 1db1A-6bo6A:
undetectable		 1db1A-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6daw NON-HEME IRON
HYDROXYLASE

(Streptomyces
lusitanus) 		no annotation 5 LEU A  15
LEU A  18
SER A  21
LEU A 162
HIS A  96
 None
 1.09A 1db1A-6dawA:
undetectable		 1db1A-6dawA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2s COAT PROTEIN SUBUNIT
I

(Ageratum yellow
vein virus) 		no annotation 5 TYR I  78
LEU I 180
LEU I 140
VAL I 141
SER I  94
 None
 1.22A 1db1A-6f2sI:
undetectable		 1db1A-6f2sI:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 5 LEU J 702
LEU J 657
VAL J 658
VAL J 686
LEU J 683
 None
 1.29A 1db1A-6fhsJ:
undetectable		 1db1A-6fhsJ:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 5 LEU A 261
SER A 265
SER A 306
CYH A 316
LEU A 419
 DZW  A 501 ( 4.5A)
DZW  A 501 (-3.0A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
None
 1.31A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 9 TYR A 175
LEU A 258
LEU A 261
SER A 265
SER A 303
SER A 306
CYH A 316
VAL A 328
LEU A 337
 None
DZW  A 501 (-3.8A)
DZW  A 501 ( 4.5A)
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
DZW  A 501 ( 4.3A)
None
 0.70A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 6 TYR A 175
LEU A 261
VAL A 262
SER A 265
SER A 303
LEU A 338
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
None
 1.24A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 11 TYR A 175
LEU A 261
VAL A 262
SER A 265
SER A 303
SER A 306
CYH A 316
VAL A 328
HIS A 333
LEU A 337
HIS A 423
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
DZW  A 501 ( 4.3A)
DZW  A 501 (-3.9A)
None
DZW  A 501 (-4.0A)
 0.31A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 6 TYR A 175
LEU A 261
VAL A 262
SER A 303
LEU A 338
HIS A 333
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.8A)
None
DZW  A 501 (-3.9A)
 1.47A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 8 TYR A 175
LEU A 261
VAL A 262
SER A 303
SER A 306
CYH A 316
LEU A 337
HIS A 333
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
None
DZW  A 501 (-3.9A)
 1.49A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 LEU A 581
LEU A 558
VAL A 583
SER A 586
LEU A 621
 None
 1.03A 1db1A-6g9oA:
undetectable		 1db1A-6g9oA:
15.73