SIMILAR PATTERNS OF AMINO ACIDS FOR 1DB1_A_VDXA428

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 LEU S 872
SER S 876
VAL S 927
LEU S 795
HIS S 827
 None
 1.34A 1db1A-1bkdS:
undetectable		 1db1A-1bkdS:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A  47
LEU A  50
VAL A  51
SER A 111
VAL A 392
 None
 1.30A 1db1A-1cg2A:
0.2		 1db1A-1cg2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		5 LEU A 326
LEU A 329
VAL A 330
SER A 332
LEU A 344
 None
 1.32A 1db1A-1f0iA:
0.0		 1db1A-1f0iA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 LEU A 521
LEU A 522
VAL A 518
VAL A 204
LEU A 273
 None
 1.12A 1db1A-1lnsA:
0.0		 1db1A-1lnsA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 LEU A 142
LEU A 139
VAL A 138
SER A  99
CYH A  92
 None
 1.16A 1db1A-1nfgA:
0.0		 1db1A-1nfgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		5 LEU A 205
SER A 198
SER A  92
LEU A  49
HIS A  61
 None
 1.29A 1db1A-1sqhA:
0.0		 1db1A-1sqhA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 TYR A 661
LEU A  18
SER A  91
VAL A 169
LEU A 236
 None
 1.34A 1db1A-1urjA:
0.0		 1db1A-1urjA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		5 LEU A 872
SER A 876
VAL A 927
LEU A 795
HIS A 827
 None
 1.34A 1db1A-1xdvA:
1.1		 1db1A-1xdvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]

(Yellow fever
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		5 LEU A 540
LEU A 546
CYH A 567
VAL A 536
LEU A 529
 None
 1.35A 1db1A-1yksA:
0.0		 1db1A-1yksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		5 TYR A 743
LEU A 530
VAL A 534
SER A 536
VAL A 505
 None
 1.30A 1db1A-1z26A:
undetectable		 1db1A-1z26A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		5 LEU A 363
LEU A 360
SER A  69
VAL A 349
LEU A 304
 None
 1.22A 1db1A-1zkdA:
undetectable		 1db1A-1zkdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		5 LEU A 363
LEU A 360
VAL A 361
SER A  69
VAL A 349
 None
 1.11A 1db1A-1zkdA:
undetectable		 1db1A-1zkdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 LEU B  70
LEU B  67
VAL B  66
SER B  63
HIS B  94
 HEM  B 200 (-3.8A)
None
HEM  B 200 ( 3.9A)
None
HEM  B 200 (-3.2A)
 1.10A 1db1A-2d2nB:
undetectable		 1db1A-2d2nB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 1.08A 1db1A-2h21A:
undetectable		 1db1A-2h21A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwx TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF13638
(PIN_4) 		5 LEU A1273
LEU A1266
SER A1320
VAL A1275
LEU A1283
 None
 1.24A 1db1A-2hwxA:
undetectable		 1db1A-2hwxA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		12 TYR A 143
LEU A 226
LEU A 229
VAL A 230
SER A 233
SER A 271
SER A 274
CYH A 284
VAL A 296
HIS A 301
LEU A 305
HIS A 393
 VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.5A)
VD4  A 500 ( 4.8A)
VD4  A 500 ( 4.6A)
VD4  A 500 ( 2.8A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 2.9A)
VD4  A 500 ( 3.4A)
VD4  A 500 ( 4.4A)
VD4  A 500 ( 3.9A)
None
VD4  A 500 ( 3.9A)
 0.30A 1db1A-2o4jA:
38.4		 1db1A-2o4jA:
90.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A  67
LEU A  76
SER A  85
VAL A 105
LEU A 114
 None
 1.36A 1db1A-2oaeA:
undetectable		 1db1A-2oaeA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm6 GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 LEU B 466
VAL B 468
SER B 384
SER B 560
VAL B 487
 None
 1.34A 1db1A-2qm6B:
undetectable		 1db1A-2qm6B:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A  20
LEU A 335
SER A 208
VAL A  15
LEU A 129
 None
 1.34A 1db1A-2qveA:
undetectable		 1db1A-2qveA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qww TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Listeria
monocytogenes) 		PF12802
(MarR_2) 		5 LEU A  83
VAL A  84
SER A 103
SER A 110
LEU A  64
 None
 1.14A 1db1A-2qwwA:
undetectable		 1db1A-2qwwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 TYR A 286
LEU A 253
VAL A 204
SER A 203
VAL A 249
 None
 1.36A 1db1A-2qytA:
undetectable		 1db1A-2qytA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		5 TYR A 243
LEU A 311
SER A 269
VAL A 309
LEU A  27
 None
 1.36A 1db1A-2qzpA:
undetectable		 1db1A-2qzpA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9y ALPHA-2-ANTIPLASMIN

(Mus musculus) 		PF00079
(Serpin) 		5 LEU A  66
LEU A  69
VAL A  70
VAL A  86
HIS A 353
 None
 1.29A 1db1A-2r9yA:
undetectable		 1db1A-2r9yA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS

(Fasciola
hepatica) 		PF14497
(GST_C_3) 		5 TYR A  93
LEU A 135
LEU A 138
VAL A 139
SER A 142
 DMS  A1212 ( 4.7A)
None
None
None
None
 1.04A 1db1A-2wduA:
undetectable		 1db1A-2wduA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 LEU A 158
LEU A 155
VAL A 152
SER A 149
LEU A 431
 None
 1.35A 1db1A-2z23A:
undetectable		 1db1A-2z23A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 SER A 272
SER A 231
SER A 198
HIS A 136
HIS A 134
 None
None
None
CU  A 701 (-3.2A)
CU  A 702 (-3.1A)
 1.25A 1db1A-3abgA:
undetectable		 1db1A-3abgA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 VAL A 265
SER A 264
SER A 200
VAL A 192
LEU A 176
 None
 1.23A 1db1A-3b05A:
undetectable		 1db1A-3b05A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		5 LEU A 593
LEU A 597
SER A 511
VAL A 564
LEU A 517
 None
None
CIT  A2000 (-4.1A)
None
None
 1.33A 1db1A-3bdlA:
undetectable		 1db1A-3bdlA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		5 LEU A 221
LEU A 224
VAL A 225
SER A 227
LEU A 145
 None
 1.12A 1db1A-3cg1A:
undetectable		 1db1A-3cg1A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		5 LEU A 216
LEU A 219
VAL A 220
SER A 222
LEU A 140
 None
 1.05A 1db1A-3cg3A:
undetectable		 1db1A-3cg3A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		5 LEU A 221
LEU A 224
VAL A 225
SER A 227
LEU A 138
 None
 1.10A 1db1A-3cijA:
undetectable		 1db1A-3cijA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e29 UNCHARACTERIZED
PROTEIN Q7WE92_BORBR

(Bordetella
bronchiseptica) 		PF03061
(4HBT) 		5 LEU A  58
LEU A  61
VAL A  62
VAL A 124
HIS A  88
 None
 1.27A 1db1A-3e29A:
undetectable		 1db1A-3e29A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec1 YQEH GTPASE

(Geobacillus
stearothermophilus) 		PF01926
(MMR_HSR1) 		5 LEU A 326
LEU A 352
VAL A 353
CYH A 345
VAL A 362
 None
 1.33A 1db1A-3ec1A:
undetectable		 1db1A-3ec1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 TYR A 575
LEU A 463
SER A 580
HIS A 637
LEU A 640
 None
 1.25A 1db1A-3fedA:
undetectable		 1db1A-3fedA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk4 ZONA PELLUCIDA 3

(Gallus gallus) 		PF00100
(Zona_pellucida)
no annotation 		5 LEU A 297
LEU A 224
VAL A 299
SER A 215
VAL C 372
 None
 1.30A 1db1A-3nk4A:
undetectable		 1db1A-3nk4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o01 CELL INVASION
PROTEIN SIPD

(Salmonella
enterica) 		PF06511
(IpaD) 		5 LEU A  87
LEU A  90
SER A  93
SER A 333
VAL A 138
 None
 1.01A 1db1A-3o01A:
undetectable		 1db1A-3o01A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 LEU A 324
VAL A 296
SER A 342
CYH A 354
VAL A 318
 None
 1.23A 1db1A-3of7A:
undetectable		 1db1A-3of7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A  35
LEU A  38
VAL A  39
SER A  42
LEU A  96
 None
 1.25A 1db1A-3pkjA:
undetectable		 1db1A-3pkjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 112
LEU A 216
SER A 205
VAL A 108
LEU A 133
 None
None
None
None
FAD  A 499 (-4.0A)
 1.33A 1db1A-3popA:
undetectable		 1db1A-3popA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3siv NHP2-LIKE PROTEIN 1

(Homo sapiens) 		PF01248
(Ribosomal_L7Ae) 		5 LEU A  22
LEU A  25
VAL A  26
SER A  29
VAL A  81
 None
 1.09A 1db1A-3sivA:
undetectable		 1db1A-3sivA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		5 LEU A 313
LEU A 188
VAL A 187
VAL A 473
LEU A 486
 None
 1.29A 1db1A-3t5oA:
undetectable		 1db1A-3t5oA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 5 LEU B 818
LEU B 907
VAL B 816
SER B 815
VAL B 854
 None
 1.11A 1db1A-3tixB:
undetectable		 1db1A-3tixB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 LEU A1212
LEU A1209
VAL A1203
SER A1240
VAL A1247
 None
 1.28A 1db1A-3ummA:
undetectable		 1db1A-3ummA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyj LYSINE-SPECIFIC
DEMETHYLASE 8

(Homo sapiens) 		PF13621
(Cupin_8) 		5 TYR A 272
LEU A 392
LEU A 329
SER A 410
SER A 318
 AKG  A 601 (-4.7A)
None
AKG  A 601 ( 4.4A)
AKG  A 601 ( 4.7A)
AKG  A 601 (-2.6A)
 1.18A 1db1A-3uyjA:
undetectable		 1db1A-3uyjA:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 233
SER A 237
SER A 278
CYH A 288
LEU A 393
 ED9  A 501 ( 4.3A)
ED9  A 501 (-2.7A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
None
 1.27A 1db1A-3wgpA:
42.0		 1db1A-3wgpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 TYR A 143
LEU A 230
LEU A 233
VAL A 234
SER A 237
SER A 275
SER A 278
CYH A 288
VAL A 300
HIS A 305
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.6A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.19A 1db1A-3wgpA:
42.0		 1db1A-3wgpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		5 LEU A 196
SER A 120
VAL A 228
LEU A 254
HIS A 253
 None
 1.29A 1db1A-3wy7A:
undetectable		 1db1A-3wy7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A  35
LEU A  38
VAL A  39
SER A  42
LEU A  96
 None
 1.25A 1db1A-3zg6A:
undetectable		 1db1A-3zg6A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 LEU A  14
VAL A 108
VAL A  78
HIS A  79
LEU A  74
 None
None
None
None
JLN  A1528 (-4.1A)
 1.07A 1db1A-4a1oA:
undetectable		 1db1A-4a1oA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 5 VAL A 225
SER A 198
SER A 159
CYH A 163
VAL A 246
 None
 1.35A 1db1A-4czxA:
undetectable		 1db1A-4czxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew9 PECTATE LYASE

(Caldicellulosiruptor
bescii) 		PF03211
(Pectate_lyase) 		5 LEU A  53
LEU A  47
VAL A  14
VAL A  56
LEU A   6
 None
None
None
None
MPD  A 207 ( 3.8A)
 1.35A 1db1A-4ew9A:
undetectable		 1db1A-4ew9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 LEU B 628
LEU B 631
VAL B 632
CYH B 588
LEU B 500
 None
 1.29A 1db1A-4f92B:
undetectable		 1db1A-4f92B:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 TYR A 324
LEU A 122
LEU A 116
VAL A 119
VAL A 125
 None
 1.26A 1db1A-4gqoA:
undetectable		 1db1A-4gqoA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF15414
(DUF4621) 		5 LEU A 116
LEU A 223
SER A  62
VAL A 186
HIS A 120
 None
 1.22A 1db1A-4h3wA:
undetectable		 1db1A-4h3wA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  27
LEU A  29
VAL A  31
SER A  71
LEU A 103
 None
 1.15A 1db1A-4je3A:
undetectable		 1db1A-4je3A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A  69
LEU A  65
SER A 180
SER A  86
VAL A  80
 None
None
None
EDO  A 403 (-2.8A)
None
 1.27A 1db1A-4lc3A:
undetectable		 1db1A-4lc3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqj HEMOGLOBIN SUBUNIT
GAMMA-2

(Homo sapiens) 		PF00042
(Globin) 		5 LEU B  71
LEU B  68
VAL B  67
VAL B 137
HIS B  92
 HEM  B 201 ( 4.6A)
None
HEM  B 201 ( 3.8A)
None
HEM  B 201 (-3.3A)
 1.23A 1db1A-4mqjB:
undetectable		 1db1A-4mqjB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU A 350
LEU A 347
VAL A 346
SER A 343
SER A 377
 None
 1.29A 1db1A-4mx2A:
undetectable		 1db1A-4mx2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbo STEROID RECEPTOR RNA
ACTIVATOR 1

(Homo sapiens) 		PF07304
(SRA1) 		5 LEU A 118
LEU A 115
VAL A 114
VAL A 198
LEU A 183
 None
 1.32A 1db1A-4nboA:
undetectable		 1db1A-4nboA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 142
LEU A 146
VAL A 188
SER A 162
VAL A 100
 None
 1.20A 1db1A-4px1A:
undetectable		 1db1A-4px1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 LEU A 904
LEU A 900
VAL A 903
SER A 920
VAL A 933
 None
 1.28A 1db1A-4q73A:
undetectable		 1db1A-4q73A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus) 		PF01546
(Peptidase_M20) 		5 LEU A 168
LEU A 239
VAL A 166
CYH A 201
VAL A 263
 None
 1.31A 1db1A-4q7aA:
undetectable		 1db1A-4q7aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 169
LEU A 172
VAL A 173
VAL A 217
LEU A 269
 None
 1.17A 1db1A-4roeA:
undetectable		 1db1A-4roeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		5 LEU A 175
LEU A 178
VAL A 179
SER A 181
LEU A 250
 None
 1.28A 1db1A-4s38A:
undetectable		 1db1A-4s38A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.17A 1db1A-4uucA:
undetectable		 1db1A-4uucA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4we6 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A  68
LEU A  71
VAL A  72
SER A  75
LEU A 111
 None
 1.34A 1db1A-4we6A:
undetectable		 1db1A-4we6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0b DOUBLE CLP-N MOTIF
PROTEIN

(Arabidopsis
thaliana) 		PF02861
(Clp_N) 		5 VAL A 221
SER A 224
SER A 124
VAL A 135
LEU A 115
 None
 1.31A 1db1A-4y0bA:
undetectable		 1db1A-4y0bA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		5 LEU A 360
SER A 339
SER A 338
CYH A 217
HIS A 363
 None
 1.27A 1db1A-4z43A:
undetectable		 1db1A-4z43A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpk GAMMA-GLUTAMYLTRANSP
EPTIDASE (GGT)

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 LEU C 466
VAL C 468
SER C 384
SER C 560
VAL C 487
 None
None
None
EDO  C 705 (-2.7A)
None
 1.31A 1db1A-5bpkC:
undetectable		 1db1A-5bpkC:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwu NUCLEOPORIN NUP188

(Chaetomium
thermophilum) 		no annotation 5 LEU A1647
LEU A1646
SER A1632
VAL A1703
LEU A1757
 None
 1.31A 1db1A-5cwuA:
undetectable		 1db1A-5cwuA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dy1 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		5 LEU A  71
VAL A  75
SER A  78
VAL A 123
HIS A 132
 None
 1.34A 1db1A-5dy1A:
undetectable		 1db1A-5dy1A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL34 PROTEIN

(Suid
alphaherpesvirus
1) 		PF04541
(Herpes_U34) 		5 LEU B  81
VAL B  80
SER B  79
SER B  21
VAL B  71
 None
 1.12A 1db1A-5e8cB:
undetectable		 1db1A-5e8cB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 LEU D 377
LEU D 420
VAL D 421
SER D 416
LEU D 574
 None
 1.25A 1db1A-5exrD:
undetectable		 1db1A-5exrD:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASD

(Escherichia
coli) 		PF09704
(Cas_Cas5d) 		5 LEU J 120
LEU J   7
VAL J 118
CYH J  43
VAL J  61
 None
 1.32A 1db1A-5h9fJ:
undetectable		 1db1A-5h9fJ:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		5 LEU A 377
SER A 356
SER A 355
CYH A 233
HIS A 380
 None
 1.20A 1db1A-5hy5A:
undetectable		 1db1A-5hy5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 LEU A 645
LEU A 652
VAL A 653
SER A 656
VAL A 545
 None
 1.17A 1db1A-5iy9A:
undetectable		 1db1A-5iy9A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 5 LEU B 338
SER B 363
SER B 358
HIS B 729
LEU B 683
 None
 1.33A 1db1A-5iz5B:
undetectable		 1db1A-5iz5B:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jx3 URACIL-DNA
GLYCOSYLASE

(Vaccinia virus) 		no annotation 5 LEU A 170
VAL A 152
HIS A 151
LEU A  57
HIS A 147
 None
 1.24A 1db1A-5jx3A:
undetectable		 1db1A-5jx3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 LEU A 489
LEU A 492
SER A 495
VAL A   8
HIS A  27
 None
 1.34A 1db1A-5laeA:
undetectable		 1db1A-5laeA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb7 KATANIN P80 WD40
REPEAT-CONTAINING
SUBUNIT B1

(Mus musculus) 		PF13925
(Katanin_con80) 		5 LEU A 570
LEU A 632
VAL A 633
SER A 635
VAL A 578
 None
 1.32A 1db1A-5lb7A:
undetectable		 1db1A-5lb7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17

(Homo sapiens) 		PF00293
(NUDIX) 		5 LEU A  93
LEU A 184
VAL A  95
CYH A  40
VAL A   4
 None
None
None
EMC  A 402 (-2.6A)
None
 1.35A 1db1A-5lf8A:
undetectable		 1db1A-5lf8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mll DNA PROCESSING CHAIN
A (DPRA)

(Helicobacter
pylori) 		no annotation 5 LEU A 179
LEU A 195
SER A 167
SER A 163
VAL A 154
 None
 1.35A 1db1A-5mllA:
undetectable		 1db1A-5mllA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 LEU A 720
LEU A 701
SER A 687
SER A 690
VAL A 738
 None
None
None
CA  A9017 (-4.8A)
None
 1.27A 1db1A-5n8pA:
undetectable		 1db1A-5n8pA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 LEU A 720
LEU A 701
SER A 687
SER A 690
VAL A 738
 None
None
None
CA  A9017 (-4.8A)
None
 1.27A 1db1A-5n97A:
undetectable		 1db1A-5n97A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A2040
LEU A2043
SER A2047
LEU A1956
HIS A1954
 None
None
None
None
GOL  A2302 (-3.9A)
 1.07A 1db1A-5nnnA:
undetectable		 1db1A-5nnnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 LEU A1065
SER A1077
SER A1080
VAL A1152
HIS A1112
 None
 1.08A 1db1A-5u1sA:
undetectable		 1db1A-5u1sA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4t PUTATIVE GENTAMICIN
METHYLTRANSFERASE

(Micromonospora
echinospora) 		no annotation 5 LEU A 141
VAL A 140
SER A 134
SER A 161
VAL A 192
 None
None
SAH  A 414 ( 4.4A)
None
None
 1.34A 1db1A-5u4tA:
undetectable		 1db1A-5u4tA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A1243
LEU A1246
VAL A1247
SER A1250
VAL A1205
 None
 1.16A 1db1A-5ujaA:
undetectable		 1db1A-5ujaA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v76 MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		no annotation 5 LEU A  37
VAL A  36
SER A  35
SER A  24
VAL A  46
 None
 1.09A 1db1A-5v76A:
undetectable		 1db1A-5v76A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 5 LEU A 508
SER A 473
SER A 458
SER A 428
LEU A 502
 None
 1.33A 1db1A-6bo6A:
undetectable		 1db1A-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6daw NON-HEME IRON
HYDROXYLASE

(Streptomyces
lusitanus) 		no annotation 5 LEU A  15
LEU A  18
SER A  21
LEU A 162
HIS A  96
 None
 1.09A 1db1A-6dawA:
undetectable		 1db1A-6dawA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2s COAT PROTEIN SUBUNIT
I

(Ageratum yellow
vein virus) 		no annotation 5 TYR I  78
LEU I 180
LEU I 140
VAL I 141
SER I  94
 None
 1.22A 1db1A-6f2sI:
undetectable		 1db1A-6f2sI:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 5 LEU J 702
LEU J 657
VAL J 658
VAL J 686
LEU J 683
 None
 1.29A 1db1A-6fhsJ:
undetectable		 1db1A-6fhsJ:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 5 LEU A 261
SER A 265
SER A 306
CYH A 316
LEU A 419
 DZW  A 501 ( 4.5A)
DZW  A 501 (-3.0A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
None
 1.31A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 9 TYR A 175
LEU A 258
LEU A 261
SER A 265
SER A 303
SER A 306
CYH A 316
VAL A 328
LEU A 337
 None
DZW  A 501 (-3.8A)
DZW  A 501 ( 4.5A)
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
DZW  A 501 ( 4.3A)
None
 0.70A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 6 TYR A 175
LEU A 261
VAL A 262
SER A 265
SER A 303
LEU A 338
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
None
 1.24A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 11 TYR A 175
LEU A 261
VAL A 262
SER A 265
SER A 303
SER A 306
CYH A 316
VAL A 328
HIS A 333
LEU A 337
HIS A 423
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
DZW  A 501 ( 4.3A)
DZW  A 501 (-3.9A)
None
DZW  A 501 (-4.0A)
 0.31A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 6 TYR A 175
LEU A 261
VAL A 262
SER A 303
LEU A 338
HIS A 333
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.8A)
None
DZW  A 501 (-3.9A)
 1.47A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 8 TYR A 175
LEU A 261
VAL A 262
SER A 303
SER A 306
CYH A 316
LEU A 337
HIS A 333
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
None
DZW  A 501 (-3.9A)
 1.49A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 LEU A 581
LEU A 558
VAL A 583
SER A 586
LEU A 621
 None
 1.03A 1db1A-6g9oA:
undetectable		 1db1A-6g9oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 LEU A 164
ILE A 102
TRP A 103
TYR A 105
 None
 1.14A 1db1A-1aqlA:
undetectable		 1db1A-1aqlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 LEU A 148
ILE A  78
TYR A 300
VAL A  44
 None
 1.04A 1db1A-1f5nA:
0.7		 1db1A-1f5nA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfr LIPASE

(Streptomyces
exfoliatus) 		PF03403
(PAF-AH_p_II) 		4 ILE A 231
ARG A 124
TYR A 237
VAL A  84
 None
 1.01A 1db1A-1jfrA:
undetectable		 1db1A-1jfrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		4 LEU A 324
ILE A 255
ARG A 269
TRP A 271
 None
None
UDP  A 353 (-3.9A)
None
 1.06A 1db1A-1jiuA:
0.0		 1db1A-1jiuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A1097
ARG A1100
TYR A1024
VAL A1090
 None
 0.87A 1db1A-1n5xA:
0.0		 1db1A-1n5xA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onl GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Thermus
thermophilus) 		PF01597
(GCV_H) 		4 LEU A 111
ILE A  76
ARG A  48
VAL A  25
 None
 0.96A 1db1A-1onlA:
0.0		 1db1A-1onlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 LEU A 138
ILE A 214
TYR A 176
VAL A 197
 None
 1.06A 1db1A-1p1mA:
0.0		 1db1A-1p1mA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		4 LEU A 103
ILE A 186
TYR A 164
VAL A 135
 None
None
MAN  A 431 ( 4.2A)
None
 1.10A 1db1A-1rmgA:
undetectable		 1db1A-1rmgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		4 ILE A 231
ARG A 101
TYR A 301
VAL A 235
 None
FE  A 321 ( 4.2A)
None
None
 1.00A 1db1A-1si1A:
0.0		 1db1A-1si1A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdq AGGRECAN CORE
PROTEIN
TENASCIN-R

(Rattus
norvegicus) 		PF00041
(fn3)
PF00059
(Lectin_C) 		4 LEU A 186
ILE B 103
ARG B  85
TYR A 162
 None
 1.12A 1db1A-1tdqA:
undetectable		 1db1A-1tdqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 LEU A 306
ARG A 336
TYR A 345
VAL A 368
 None
 1.05A 1db1A-1w5tA:
undetectable		 1db1A-1w5tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acm MUCIN-1

(Homo sapiens) 		PF01390
(SEA)
no annotation 		4 LEU A1069
ILE B1136
TYR B1132
VAL B1101
 None
 1.11A 1db1A-2acmA:
undetectable		 1db1A-2acmA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		4 ILE A 235
ARG A 271
TRP A 246
VAL A 211
 None
 0.84A 1db1A-2e9wA:
undetectable		 1db1A-2e9wA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2p TRANSTHYRETIN-LIKE
PROTEIN

(Escherichia
coli) 		PF00576
(Transthyretin) 		4 LEU A   6
ILE A  84
TYR A 111
VAL A  24
 None
None
SO4  A1102 (-4.2A)
None
 1.09A 1db1A-2g2pA:
undetectable		 1db1A-2g2pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf0 GTP-BINDING PROTEIN
DI-RAS1

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A 160
ILE A 104
TRP A 142
VAL A  10
 None
 1.03A 1db1A-2gf0A:
undetectable		 1db1A-2gf0A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hn1 MAGNESIUM AND COBALT
TRANSPORTER

(Archaeoglobus
fulgidus) 		PF01544
(CorA) 		4 LEU A 113
ILE A 152
ARG A 153
VAL A 138
 None
 1.11A 1db1A-2hn1A:
undetectable		 1db1A-2hn1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i71 HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF09455
(Cas_DxTHG) 		4 LEU A 176
ILE A  81
TYR A  15
VAL A   5
 None
 1.02A 1db1A-2i71A:
undetectable		 1db1A-2i71A:
19.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		6 LEU A 223
ILE A 267
ARG A 270
TRP A 282
TYR A 291
VAL A 414
 None
VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.0A)
VD4  A 500 ( 3.7A)
None
None
 0.18A 1db1A-2o4jA:
38.4		 1db1A-2o4jA:
90.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph7 UNCHARACTERIZED
PROTEIN AF_2093

(Archaeoglobus
fulgidus) 		no annotation 4 LEU A 196
ILE A 208
TYR A 214
VAL A 171
 None
 1.13A 1db1A-2ph7A:
undetectable		 1db1A-2ph7A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pie E3 UBIQUITIN-PROTEIN
LIGASE RNF8

(Homo sapiens) 		PF00498
(FHA) 		4 LEU A  66
ILE A  59
ARG A  42
VAL A  85
 None
 0.99A 1db1A-2pieA:
undetectable		 1db1A-2pieA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE

(Escherichia
coli) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 LEU A 284
ARG A 315
TYR A 108
VAL A 303
 None
 1.09A 1db1A-2tptA:
undetectable		 1db1A-2tptA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5t NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		4 LEU A 250
ILE A 258
ARG A 269
TYR A 279
 None
 1.09A 1db1A-2v5tA:
undetectable		 1db1A-2v5tA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		4 LEU A 151
ILE A 210
ARG A 213
VAL A 160
 None
 1.11A 1db1A-2x9pA:
1.8		 1db1A-2x9pA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrv AT-RICH INTERACTIVE
DOMAIN-CONTAINING
PROTEIN 4A

(Homo sapiens) 		PF08169
(RBB1NT) 		4 LEU A  86
ILE A  67
ARG A  64
VAL A  70
 None
 1.10A 1db1A-2yrvA:
undetectable		 1db1A-2yrvA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		4 LEU A 220
ILE A 167
TYR A  18
VAL A 236
 None
NAD  A3001 ( 4.9A)
None
None
 0.89A 1db1A-3a1nA:
undetectable		 1db1A-3a1nA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apq DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 LEU A 192
ILE A 132
TRP A 168
TYR A 154
 None
 1.03A 1db1A-3apqA:
1.5		 1db1A-3apqA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 4 LEU A   7
ILE A 454
TYR A 457
VAL A  74
 None
 1.05A 1db1A-3c8vA:
undetectable		 1db1A-3c8vA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		4 LEU A  66
ILE A  49
ARG A   2
VAL A  12
 None
 1.14A 1db1A-3d1rA:
undetectable		 1db1A-3d1rA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 413
ARG A 365
TYR A 307
VAL A 246
 None
 1.12A 1db1A-3e60A:
undetectable		 1db1A-3e60A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 130
ILE A   9
TYR A 127
VAL A 163
 None
 1.13A 1db1A-3eyaA:
undetectable		 1db1A-3eyaA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2

(Homo sapiens) 		PF01852
(START) 		4 LEU A 443
ARG A 414
TYR A 547
VAL A 432
 None
 0.88A 1db1A-3fo5A:
undetectable		 1db1A-3fo5A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 201
ILE A 254
ARG A 483
VAL A  51
 None
 0.88A 1db1A-3gdnA:
undetectable		 1db1A-3gdnA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grc SENSOR PROTEIN,
KINASE

(Polaromonas sp.
JS666) 		PF00072
(Response_reg) 		4 LEU A 567
ILE A 624
TYR A 592
VAL A 627
 None
 1.10A 1db1A-3grcA:
undetectable		 1db1A-3grcA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5i RESPONSE
REGULATOR/SENSORY
BOX PROTEIN/GGDEF
DOMAIN PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00072
(Response_reg) 		4 LEU A 120
ILE A  19
TYR A  26
VAL A  80
 None
 1.06A 1db1A-3h5iA:
undetectable		 1db1A-3h5iA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		4 LEU A 205
ILE A 232
ARG A 233
VAL A 191
 None
 1.06A 1db1A-3jv9A:
undetectable		 1db1A-3jv9A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A  47
ILE A  13
ARG A  14
TYR A 295
 None
 1.12A 1db1A-3komA:
undetectable		 1db1A-3komA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		4 LEU A 145
ILE A  75
ARG A  76
VAL A 108
 None
 1.10A 1db1A-3ky9A:
undetectable		 1db1A-3ky9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 413
ARG A 365
TYR A 307
VAL A 246
 None
 1.10A 1db1A-3kzuA:
undetectable		 1db1A-3kzuA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm4 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus
jostii) 		PF00903
(Glyoxalase) 		4 LEU A 117
ILE A 153
TRP A  55
VAL A 202
 None
 1.05A 1db1A-3lm4A:
undetectable		 1db1A-3lm4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsp DEST

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 LEU A 169
ILE A 121
TYR A 115
VAL A  67
 None
 1.11A 1db1A-3lspA:
undetectable		 1db1A-3lspA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LEU B 256
ILE B 207
ARG B 208
VAL B 236
 SF4  B 586 ( 4.9A)
None
None
None
 1.09A 1db1A-3mm5B:
undetectable		 1db1A-3mm5B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 LEU A 163
ILE A 110
TYR A 105
VAL A 326
 None
 1.10A 1db1A-3n6xA:
undetectable		 1db1A-3n6xA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 406
ARG A 358
TYR A 299
VAL A 238
 None
 1.07A 1db1A-3o04A:
undetectable		 1db1A-3o04A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 321
ILE A 350
TYR A 380
VAL A 313
 None
 0.98A 1db1A-3o6nA:
undetectable		 1db1A-3o6nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 LEU B 321
ILE B 350
TYR B 380
VAL B 313
 None
 0.94A 1db1A-3ojaB:
undetectable		 1db1A-3ojaB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 311
ILE A 236
ARG A 266
TYR A 140
 None
 1.08A 1db1A-3p5pA:
2.1		 1db1A-3p5pA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 LEU A 217
ILE A 297
ARG A 293
VAL A 187
 None
 0.97A 1db1A-3qbdA:
undetectable		 1db1A-3qbdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1x 2-OXO-3-DEOXYGALACTO
NATE KINASE

(Klebsiella
pneumoniae) 		PF05035
(DGOK) 		4 LEU A 228
ILE A 266
ARG A 268
TYR A 259
 None
 1.05A 1db1A-3r1xA:
undetectable		 1db1A-3r1xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 201
ILE A 255
ARG A 484
VAL A  51
 None
 0.91A 1db1A-3redA:
undetectable		 1db1A-3redA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE C1097
ARG C1100
TYR C1024
VAL C1090
 None
 0.91A 1db1A-3sr6C:
undetectable		 1db1A-3sr6C:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 LEU A  60
ILE A 153
TRP A 467
VAL A 110
 None
 1.13A 1db1A-3sutA:
undetectable		 1db1A-3sutA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t43 HIV EPITOPE-SCAFFOLD
4E10_1XIZA_S0_006_C

(synthetic
construct) 		PF00359
(PTS_EIIA_2) 		4 LEU A  11
ILE A 110
TRP A 105
VAL A  85
 None
 1.11A 1db1A-3t43A:
undetectable		 1db1A-3t43A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w8j PROTEIN
DISULFIDE-ISOMERASE
A6

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 LEU A  89
ILE A  28
TRP A  65
TYR A  51
 None
 1.12A 1db1A-3w8jA:
undetectable		 1db1A-3w8jA:
17.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 227
ILE A 271
ARG A 274
TRP A 286
TYR A 295
VAL A 418
 None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.5A)
None
None
 0.14A 1db1A-3wgpA:
42.0		 1db1A-3wgpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		4 LEU A  38
ILE A 344
TYR A  29
VAL A  61
 None
 0.97A 1db1A-3wvsA:
undetectable		 1db1A-3wvsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aby DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 LEU A 155
ILE A 399
ARG A 400
VAL A 445
 None
 1.08A 1db1A-4abyA:
undetectable		 1db1A-4abyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 LEU A 201
ILE A 287
TYR A 252
VAL A 246
 None
 1.02A 1db1A-4ecnA:
undetectable		 1db1A-4ecnA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emi TODA

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 LEU A  21
ILE A  33
TYR A  67
VAL A 104
 None
FAD  A 501 ( 4.6A)
None
None
 0.98A 1db1A-4emiA:
undetectable		 1db1A-4emiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		4 LEU A  87
ILE A  62
ARG A  59
VAL A  41
 None
 1.04A 1db1A-4gxwA:
undetectable		 1db1A-4gxwA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 228
ILE A 279
ARG A 542
VAL A  42
 None
 0.96A 1db1A-4h7uA:
undetectable		 1db1A-4h7uA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igo OS05G0196500 PROTEIN

(Oryza sativa) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 LEU A 219
TRP A 414
TYR A 415
VAL A 319
 None
 1.00A 1db1A-4igoA:
undetectable		 1db1A-4igoA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqf METHIONYL-TRNA
FORMYLTRANSFERASE

(Bacillus
anthracis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 LEU A 238
ILE A 225
TYR A 235
VAL A 272
 None
 1.09A 1db1A-4iqfA:
undetectable		 1db1A-4iqfA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 421
ARG A 373
TYR A 314
VAL A 253
 None
 1.14A 1db1A-4jgaA:
undetectable		 1db1A-4jgaA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqk PROTEIN A46

(Vaccinia virus) 		no annotation 4 LEU C 184
ARG C 159
TYR C  98
VAL C 150
 None
 1.10A 1db1A-4lqkC:
undetectable		 1db1A-4lqkC:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 349
ILE A 338
TYR A 468
VAL A 294
 None
 1.03A 1db1A-4nleA:
undetectable		 1db1A-4nleA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 LEU A 493
ILE A 324
ARG A 516
VAL A 476
 None
 1.07A 1db1A-4q2cA:
undetectable		 1db1A-4q2cA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrk HYPOTHETICAL PROTEIN

(Clostridium
sporogenes) 		PF09922
(DUF2154)
PF17115
(Toast_rack_N) 		4 LEU A 145
ILE A 235
TYR A 188
VAL A 155
 None
 1.05A 1db1A-4qrkA:
undetectable		 1db1A-4qrkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 LEU A 235
ILE A 130
ARG A 133
VAL A 266
 None
 0.83A 1db1A-4r6hA:
undetectable		 1db1A-4r6hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		4 LEU A 245
ILE A 327
TYR A 154
VAL A 319
 None
 1.06A 1db1A-4r6yA:
undetectable		 1db1A-4r6yA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf ADRENOMEDULLIN
MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00214
(Calc_CGRP_IAPP)
PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 LEU A1109
ILE A1120
TYR B  52
VAL A1065
 None
 0.96A 1db1A-4rwfA:
undetectable		 1db1A-4rwfA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		4 LEU B1031
ILE B1016
ARG B1197
VAL B1138
 None
 1.14A 1db1A-4tshB:
undetectable		 1db1A-4tshB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1

(Homo sapiens) 		PF05609
(LAP1C) 		4 LEU A 536
ILE A 409
TYR A 493
VAL A 568
 None
 1.11A 1db1A-4tvsA:
undetectable		 1db1A-4tvsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 215
ILE A 263
ARG A 497
VAL A  32
 None
 1.10A 1db1A-4udrA:
undetectable		 1db1A-4udrA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		4 LEU A 292
ILE A 240
ARG A 239
VAL A 218
 None
 1.05A 1db1A-4ur8A:
undetectable		 1db1A-4ur8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnx NETRIN-4

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 LEU A  47
ILE A 221
ARG A 146
VAL A 258
 None
 1.08A 1db1A-4wnxA:
undetectable		 1db1A-4wnxA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 LEU A 162
ILE A 191
TYR A 221
VAL A 154
 None
 1.01A 1db1A-4xgoA:
undetectable		 1db1A-4xgoA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 107
ILE A 168
ARG A 144
VAL A 134
 None
 1.00A 1db1A-4zk3A:
undetectable		 1db1A-4zk3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzd TRANSCRIPTIONAL
REGULATOR, PADR-LIKE
FAMILY

(Lactococcus
lactis) 		PF03551
(PadR) 		4 LEU A  45
ILE A  63
TYR A  51
VAL A  20
 None
 0.94A 1db1A-4zzdA:
undetectable		 1db1A-4zzdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3i ANTI-HAEMAGGLUTININ
HA1 FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU C  45
ILE C  50
ARG C  59
VAL C 112
 None
 0.90A 1db1A-5a3iC:
undetectable		 1db1A-5a3iC:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		4 LEU A 204
ILE A  77
TRP A  79
VAL A 154
 None
 0.90A 1db1A-5dt5A:
undetectable		 1db1A-5dt5A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e25 BRANCHED-CHAIN
AMINOTRANSFERASE

(Geoglobus
acetivorans) 		PF01063
(Aminotran_4) 		4 LEU A  28
ILE A  93
ARG A  91
VAL A  20
 None
None
AKG  A 302 ( 4.1A)
None
 0.94A 1db1A-5e25A:
undetectable		 1db1A-5e25A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 201
ILE A 255
ARG A 484
VAL A  51
 None
 0.85A 1db1A-5eb5A:
undetectable		 1db1A-5eb5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		4 ILE A1093
TRP A1110
TYR A1141
VAL A1076
 None
 1.05A 1db1A-5f3yA:
undetectable		 1db1A-5f3yA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU B 109
ILE B 143
TYR B 153
VAL B  60
 None
 1.13A 1db1A-5fq6B:
undetectable		 1db1A-5fq6B:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ILE A  84
ARG A  85
TYR A 143
VAL A  59
 None
 0.75A 1db1A-5fr8A:
undetectable		 1db1A-5fr8A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gaj DE NOVO DESIGNED
PROTEIN OR258

(synthetic
construct) 		no annotation 4 LEU A  23
ILE A  83
ARG A 107
VAL A  55
 None
 1.03A 1db1A-5gajA:
undetectable		 1db1A-5gajA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE

(Shewanella
oneidensis) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 112
ILE A 356
TYR A 326
VAL A 120
 None
 0.99A 1db1A-5k8bA:
undetectable		 1db1A-5k8bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Archaeoglobus
fulgidus) 		no annotation 4 LEU A  26
ILE A  91
ARG A  89
VAL A  18
 None
 1.09A 1db1A-5mqzA:
undetectable		 1db1A-5mqzA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 281
ILE A 338
ARG A 606
VAL A 110
 None
 0.80A 1db1A-5nccA:
undetectable		 1db1A-5nccA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 4 LEU A 274
ILE A 364
TYR A 306
VAL A 349
 None
 1.03A 1db1A-5ny0A:
undetectable		 1db1A-5ny0A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 301
ILE A 372
TYR A 343
VAL A 338
 None
 1.01A 1db1A-5suiA:
undetectable		 1db1A-5suiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		4 LEU A  80
ILE A  33
TYR A  45
VAL A  59
 None
None
None
NAD  A 503 (-4.9A)
 1.06A 1db1A-5tprA:
undetectable		 1db1A-5tprA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Trypanosoma
brucei) 		PF01536
(SAM_decarbox) 		4 ILE A  98
ARG B  34
TYR A 274
VAL B  82
 None
None
None
PYR  A 401 (-3.7A)
 1.07A 1db1A-5tvoA:
undetectable		 1db1A-5tvoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum) 		PF01547
(SBP_bac_1) 		4 LEU A  55
ARG A 331
TYR A 341
VAL A  44
 None
 1.13A 1db1A-5u2pA:
undetectable		 1db1A-5u2pA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A

(Homo sapiens) 		PF00628
(PHD)
PF01388
(ARID)
PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2)
PF08429
(PLU-1) 		4 LEU A  80
TRP A 503
TYR A 504
VAL A 407
 None
90S  A 904 (-4.7A)
None
None
 1.11A 1db1A-5v9pA:
undetectable		 1db1A-5v9pA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvh OCTOPINE
CATABOLISM/UPTAKE
OPERON REGULATORY
PROTEIN OCCR

(Agrobacterium
tumefaciens) 		PF03466
(LysR_substrate) 		4 ILE A 143
ARG A 266
TRP A 284
VAL A 122
 None
 0.78A 1db1A-5vvhA:
undetectable		 1db1A-5vvhA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdh KINESIN-LIKE PROTEIN
KIFC1

(Homo sapiens) 		PF00225
(Kinesin) 		4 LEU A 628
ILE A 464
TYR A 622
VAL A 564
 None
 1.14A 1db1A-5wdhA:
undetectable		 1db1A-5wdhA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14

(Arabidopsis
thaliana) 		no annotation 4 LEU A 121
TRP A 329
TYR A 330
VAL A 234
 None
 1.03A 1db1A-5yknA:
undetectable		 1db1A-5yknA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 4 LEU A 256
ARG A 244
TYR A 275
VAL A 194
 None
 0.90A 1db1A-5yv5A:
undetectable		 1db1A-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 6 LEU A 255
ILE A 299
ARG A 302
TRP A 314
TYR A 323
VAL A 444
 None
DZW  A 501 (-4.7A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.5A)
DZW  A 501 (-3.6A)
None
 0.28A 1db1A-6fobA:
37.2		 1db1A-6fobA:
23.26