SIMILAR PATTERNS OF AMINO ACIDS FOR 1D4Y_A_TPVA501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a21 TISSUE FACTOR

(Oryctolagus
cuniculus)
PF01108
(Tissue_fac)
PF09294
(Interfer-bind)
4 LEU A 121
ALA A 166
VAL A 177
ILE A 175
None
0.65A 1d4yB-1a21A:
undetectable
1d4yB-1a21A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)


(Escherichia
coli)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
4 LEU A 326
ALA A 379
GLY A 419
ILE A 384
None
0.67A 1d4yB-1bbuA:
0.0
1d4yB-1bbuA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)


(Saccharomyces
cerevisiae)
PF01088
(Peptidase_C12)
4 ARG A 208
LEU A  39
GLY A 232
ILE A  36
None
0.53A 1d4yB-1cmxA:
undetectable
1d4yB-1cmxA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli)
PF00155
(Aminotran_1_2)
4 LEU A 167
ALA A 120
VAL A 114
ILE A 116
None
0.63A 1d4yB-1d2fA:
undetectable
1d4yB-1d2fA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlm CATECHOL
1,2-DIOXYGENASE


(Acinetobacter
sp. ADP1)
PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N)
4 LEU A 290
ALA A 151
GLY A 119
ILE A 140
None
0.68A 1d4yB-1dlmA:
0.0
1d4yB-1dlmA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens)
PF01341
(Glyco_hydro_6)
4 LEU A 170
ILE A  66
VAL A 134
ILE A 175
None
0.71A 1d4yB-1dysA:
undetectable
1d4yB-1dysA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE


(Escherichia
coli)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
4 LEU A 326
ALA A 379
GLY A 419
ILE A 384
None
None
None
GOL  A 609 ( 3.9A)
0.65A 1d4yB-1e1tA:
0.0
1d4yB-1e1tA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek6 UDP-GALACTOSE
4-EPIMERASE


(Homo sapiens)
PF16363
(GDP_Man_Dehyd)
4 LEU A  68
ALA A  89
ILE A 164
ILE A  67
None
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
0.69A 1d4yB-1ek6A:
undetectable
1d4yB-1ek6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5g FUSION PROTEIN

(Avian
avulavirus 1)
PF00523
(Fusion_gly)
4 LEU A 386
GLY A  41
ILE A  42
ILE A 391
None
0.64A 1d4yB-1g5gA:
undetectable
1d4yB-1g5gA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE


(Streptomyces
clavuligerus)
PF00491
(Arginase)
4 ALA A 244
ILE A 292
VAL A 277
ILE A 236
None
0.66A 1d4yB-1gq7A:
undetectable
1d4yB-1gq7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus)
PF00150
(Cellulase)
4 ALA A 173
GLY A 236
ILE A 237
ILE A 222
None
0.71A 1d4yB-1gzjA:
undetectable
1d4yB-1gzjA:
14.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ARG A   8
LEU A  23
ALA A  28
GLY A  49
ILE A  50
A79  A 800 (-3.4A)
A79  A 800 ( 3.8A)
A79  A 800 (-3.1A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
0.58A 1d4yB-1hvcA:
14.1
1d4yB-1hvcA:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 ARG A   8
LEU A  23
ALA A  28
GLY A  49
ILE A  50
VAL A  82
A79  A 800 (-3.6A)
A79  A 800 ( 4.0A)
A79  A 800 (-3.2A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
A79  A 800 (-4.5A)
0.53A 1d4yB-1hvcA:
14.1
1d4yB-1hvcA:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ARG A   8
LEU A  23
ASP A  25
ALA A  28
GLY A  49
A79  A 800 (-3.4A)
A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 ( 3.7A)
0.48A 1d4yB-1hvcA:
14.1
1d4yB-1hvcA:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 ARG A   8
LEU A  23
ASP A  25
ALA A  28
GLY A  49
VAL A  82
A79  A 800 (-3.6A)
A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 (-3.4A)
A79  A 800 (-4.5A)
0.44A 1d4yB-1hvcA:
14.1
1d4yB-1hvcA:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ARG A   8
LEU A  23
ASP A  25
ALA A  28
ILE A  84
A79  A 800 (-3.4A)
A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 (-3.8A)
1.04A 1d4yB-1hvcA:
14.1
1d4yB-1hvcA:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ARG A   8
LEU A  23
ASP A  25
ALA A  28
ILE A  84
A79  A 800 (-3.6A)
A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 (-3.6A)
1.02A 1d4yB-1hvcA:
14.1
1d4yB-1hvcA:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 LEU A  23
ALA A  28
GLY A  49
ILE A  50
VAL A  82
ILE A  84
A79  A 800 ( 3.8A)
A79  A 800 (-3.1A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
A79  A 800 (-4.5A)
A79  A 800 (-3.6A)
0.53A 1d4yB-1hvcA:
14.1
1d4yB-1hvcA:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 LEU A  23
ALA A  28
GLY A  49
ILE A  50
VAL A  82
ILE A  84
A79  A 800 ( 4.0A)
A79  A 800 (-3.2A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
A79  A 800 (-4.5A)
A79  A 800 (-3.8A)
0.54A 1d4yB-1hvcA:
14.1
1d4yB-1hvcA:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 LEU A  23
ASP A  25
ALA A  28
GLY A  49
VAL A  82
ILE A  84
A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 ( 3.7A)
A79  A 800 (-4.5A)
A79  A 800 (-3.6A)
0.44A 1d4yB-1hvcA:
14.1
1d4yB-1hvcA:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 LEU A  23
ASP A  25
ALA A  28
GLY A  49
VAL A  82
ILE A  84
A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 (-3.4A)
A79  A 800 (-4.5A)
A79  A 800 (-3.8A)
0.46A 1d4yB-1hvcA:
14.1
1d4yB-1hvcA:
47.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ith HEMOGLOBIN (CYANO
MET)


(Urechis caupo)
PF00042
(Globin)
5 LEU A  79
ALA A 128
GLY A 112
VAL A  76
ILE A  10
None
1.16A 1d4yB-1ithA:
undetectable
1d4yB-1ithA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR


(Escherichia
coli)
PF00356
(LacI)
PF13377
(Peripla_BP_3)
4 ALA A  66
GLY A  63
ILE A  93
ILE A  78
None
0.64A 1d4yB-1jftA:
undetectable
1d4yB-1jftA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwq N-ACETYLMURAMOYL-L-A
LANINE AMIDASE CWLV


(Paenibacillus
polymyxa)
PF01520
(Amidase_3)
4 LEU A 141
ILE A  40
VAL A  77
ILE A  79
None
0.69A 1d4yB-1jwqA:
undetectable
1d4yB-1jwqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae)
PF00082
(Peptidase_S8)
PF01483
(P_proprotein)
4 LEU A 452
ALA A 401
GLY A 166
ILE A 453
None
0.66A 1d4yB-1ot5A:
undetectable
1d4yB-1ot5A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8y GLYCINE
N-METHYLTRANSFERASE


(Mus musculus)
PF13847
(Methyltransf_31)
4 GLY A  68
ILE A  72
VAL A  60
ILE A 134
None
0.70A 1d4yB-1r8yA:
undetectable
1d4yB-1r8yA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rif DNA HELICASE UVSW

(Escherichia
virus T4)
PF04851
(ResIII)
4 ALA A 237
GLY A 257
ILE A 132
ILE A 242
None
None
AU  A 287 ( 4.7A)
None
0.70A 1d4yB-1rifA:
undetectable
1d4yB-1rifA:
14.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
5 ARG A   8
LEU A  23
ASP A  25
GLY A  49
ILE A  84
None
0.63A 1d4yB-1sivA:
18.4
1d4yB-1sivA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
5 ARG A   8
LEU A  23
GLY A  49
ILE A  50
ILE A  84
None
0.76A 1d4yB-1sivA:
18.4
1d4yB-1sivA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
5 LEU A  23
ASP A  25
ALA A  28
GLY A  49
ILE A  84
None
0.55A 1d4yB-1sivA:
18.4
1d4yB-1sivA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT


(Thermotoga
maritima)
PF13393
(tRNA-synt_His)
4 ALA C 251
ILE C 238
VAL C 109
ILE C 113
None
0.63A 1d4yB-1usyC:
undetectable
1d4yB-1usyC:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Thermus
thermophilus)
PF03009
(GDPD)
4 LEU A  32
ALA A  16
GLY A 213
ILE A 212
None
None
None
GOL  A 300 ( 4.9A)
0.70A 1d4yB-1vd6A:
undetectable
1d4yB-1vd6A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8a SLIT PROTEIN

(Drosophila
melanogaster)
PF00560
(LRR_1)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8)
4 GLY A 609
ILE A 610
VAL A 658
ILE A 655
None
0.53A 1d4yB-1w8aA:
undetectable
1d4yB-1w8aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG


(Thermus
thermophilus)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II)
4 ALA A 237
GLY A 231
VAL A 208
ILE A 212
None
0.65A 1d4yB-1wdtA:
undetectable
1d4yB-1wdtA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens)
PF00274
(Glycolytic)
5 ARG A  60
LEU A  63
ALA A 332
GLY A  29
ILE A  30
None
1.48A 1d4yB-1xfbA:
undetectable
1d4yB-1xfbA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB


(Mycobacterium
tuberculosis)
PF02518
(HATPase_c)
5 LEU A 309
ALA A 367
GLY A 373
VAL A 304
ILE A 306
None
None
TRS  A1001 (-3.3A)
None
None
1.14A 1d4yB-1ysrA:
undetectable
1d4yB-1ysrA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
4 LEU A 362
ALA A 588
GLY A 582
ILE A 416
None
0.66A 1d4yB-1z8lA:
undetectable
1d4yB-1z8lA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]


(Ogataea angusta)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
4 LEU A 256
ALA A 180
VAL A 107
ILE A 109
None
0.63A 1d4yB-2bihA:
undetectable
1d4yB-2bihA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]


(Ogataea angusta)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
4 LEU A 256
ALA A 180
VAL A 107
ILE A 109
None
0.57A 1d4yB-2biiA:
undetectable
1d4yB-2biiA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwa ENDOGLUCANASE

(Rhodothermus
marinus)
PF01670
(Glyco_hydro_12)
4 LEU A   5
GLY A 205
VAL A  36
ILE A  34
None
0.66A 1d4yB-2bwaA:
undetectable
1d4yB-2bwaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli)
PF12706
(Lactamase_B_2)
4 ALA A 297
ILE A   4
VAL A 228
ILE A 267
None
0.70A 1d4yB-2cbnA:
undetectable
1d4yB-2cbnA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis)
PF04185
(Phosphoesterase)
4 ALA A  25
GLY A 312
ILE A 311
VAL A  38
None
0.64A 1d4yB-2d1gA:
undetectable
1d4yB-2d1gA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284


(Pyrococcus
horikoshii)
PF06745
(ATPase)
4 ALA A 129
GLY A  84
VAL A  89
ILE A  55
None
0.70A 1d4yB-2dr3A:
undetectable
1d4yB-2dr3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
5 LEU A  36
GLY A  88
ILE A  87
VAL A  75
ILE A  18
None
1.11A 1d4yB-2e8yA:
undetectable
1d4yB-2e8yA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 LEU A 265
GLY A 326
VAL A 287
ILE A 285
None
0.66A 1d4yB-2ep5A:
undetectable
1d4yB-2ep5A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2


(Archaeoglobus
fulgidus)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 ARG A  18
LEU A  69
GLY A  83
ILE A  86
ILE A  76
None
1.23A 1d4yB-2f3oA:
undetectable
1d4yB-2f3oA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582


(Listeria
monocytogenes)
PF02384
(N6_Mtase)
5 LEU A 321
ALA A 306
GLY A 269
ILE A 289
ILE A 320
None
1.49A 1d4yB-2f8lA:
undetectable
1d4yB-2f8lA:
14.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE


(Equine
infectious
anemia virus)
PF00077
(RVP)
7 ARG A   8
LEU A  23
ASP A  25
ALA A  28
GLY A  55
VAL A  87
ILE A  89
LP1  A 201 (-3.5A)
None
LP1  A 201 (-2.3A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.4A)
LP1  A 201 ( 4.9A)
LP1  A 201 (-4.2A)
0.53A 1d4yB-2fmbA:
15.2
1d4yB-2fmbA:
33.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE


(Desulfovibrio
gigas)
no annotation 4 GLY L 508
ILE L 507
VAL L 524
ILE L 520
None
0.69A 1d4yB-2frvL:
undetectable
1d4yB-2frvL:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri)
PF01979
(Amidohydro_1)
5 ALA A 277
GLY A 346
ILE A 343
VAL A 264
ILE A 265
None
1.18A 1d4yB-2fvmA:
undetectable
1d4yB-2fvmA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN


(Caldanaerobacter
subterraneus)
PF13407
(Peripla_BP_4)
4 ALA A  27
GLY A 245
VAL A  36
ILE A  34
None
0.60A 1d4yB-2ioyA:
undetectable
1d4yB-2ioyA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FERREDOXIN,
CHLOROPLASTIC


(Chlamydomonas
reinhardtii)
PF00111
(Fer2)
4 LEU B   5
ALA B  29
VAL B   3
ILE B  14
None
0.70A 1d4yB-2n0sB:
undetectable
1d4yB-2n0sB:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n76 DE NOVO DESIGNED
PROTEIN LFR1


(synthetic
construct)
no annotation 5 LEU A  55
ALA A  18
GLY A  51
VAL A   8
ILE A  10
None
1.48A 1d4yB-2n76A:
undetectable
1d4yB-2n76A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW


(Escherichia
virus T4)
PF00271
(Helicase_C)
PF04851
(ResIII)
4 ALA A 237
GLY A 257
ILE A 132
ILE A 242
None
0.70A 1d4yB-2ocaA:
undetectable
1d4yB-2ocaA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE


(Geobacillus
kaustophilus)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 LEU A 298
ALA A 294
GLY A 126
ILE A 130
None
0.69A 1d4yB-2oejA:
undetectable
1d4yB-2oejA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0l LIPOATE-PROTEIN
LIGASE A


(Streptococcus
agalactiae)
PF03099
(BPL_LplA_LipB)
4 LEU A  49
ILE A 240
VAL A  13
ILE A  15
None
0.62A 1d4yB-2p0lA:
undetectable
1d4yB-2p0lA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1


(Saccharomyces
cerevisiae)
PF00012
(HSP70)
4 LEU A   7
ILE A 163
VAL A 141
ILE A 143
None
0.64A 1d4yB-2qxlA:
undetectable
1d4yB-2qxlA:
9.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
7 ARG A   8
LEU A  23
ASP A  25
ALA A  28
GLY A  49
ILE A  50
ILE A  84
AB1  A 501 ( 4.7A)
None
AB1  A 501 (-2.4A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.8A)
AB1  A 501 ( 4.2A)
0.49A 1d4yB-2rkfA:
20.5
1d4yB-2rkfA:
84.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rsp RSV PROTEASE

(Rous sarcoma
virus)
PF00077
(RVP)
5 ARG A  10
LEU A  35
ASP A  37
ALA A  40
ILE A 108
None
0.82A 1d4yB-2rspA:
12.9
1d4yB-2rspA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
4 ARG A 210
ALA A 332
GLY A 329
ILE A 234
OMT  A2473 (-3.9A)
None
None
None
0.68A 1d4yB-2vdcA:
undetectable
1d4yB-2vdcA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis)
PF01177
(Asp_Glu_race)
4 LEU A  89
ILE A  33
VAL A  93
ILE A  91
None
0.59A 1d4yB-2vvtA:
undetectable
1d4yB-2vvtA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus)
no annotation 4 LEU A 351
ALA A 335
GLY A 318
ILE A 358
None
0.68A 1d4yB-2x0fA:
undetectable
1d4yB-2x0fA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA


(Homo sapiens)
PF01602
(Adaptin_N)
4 LEU B 396
ALA B 410
ILE B 451
ILE B 399
None
0.71A 1d4yB-2xa7B:
undetectable
1d4yB-2xa7B:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y23 MYOMESIN

(Homo sapiens)
PF07679
(I-set)
5 ASP A1401
GLY A1409
ILE A1410
VAL A1428
ILE A1389
None
0.90A 1d4yB-2y23A:
undetectable
1d4yB-2y23A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9)
PF01565
(FAD_binding_4)
PF08031
(BBE)
4 ALA A 344
GLY A 247
VAL A 372
ILE A 400
None
0.58A 1d4yB-2y3sA:
undetectable
1d4yB-2y3sA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Peptoniphilus
asaccharolyticus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 LEU A 317
ALA A 213
GLY A 236
ILE A 231
ILE A 208
None
1.12A 1d4yB-2yfqA:
undetectable
1d4yB-2yfqA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID


(Neisseria
gonorrhoeae)
PF00497
(SBP_bac_3)
5 LEU A 188
ALA A 196
ILE A 154
VAL A 218
ILE A 191
None
1.34A 1d4yB-2ylnA:
undetectable
1d4yB-2ylnA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxb COENZYME
B12-DEPENDENT MUTASE


(Aeropyrum
pernix)
PF02310
(B12-binding)
5 ARG A  90
LEU A  87
GLY A  76
ILE A  75
ILE A  79
None
1.35A 1d4yB-2yxbA:
undetectable
1d4yB-2yxbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3b ATP-DEPENDENT
PROTEASE HSLV


(Bacillus
subtilis)
PF00227
(Proteasome)
4 LEU A 111
ALA A  10
GLY A  21
ILE A 102
None
0.69A 1d4yB-2z3bA:
undetectable
1d4yB-2z3bA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2


(Methanocaldococcus
jannaschii)
PF00155
(Aminotran_1_2)
4 ALA A 321
GLY A 335
ILE A 336
ILE A  17
None
0.68A 1d4yB-2z61A:
undetectable
1d4yB-2z61A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE


(Pyrococcus
furiosus)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5)
5 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
None
1.02A 1d4yB-2zj8A:
undetectable
1d4yB-2zj8A:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0u RESPONSE REGULATOR

(Thermotoga
maritima)
PF00072
(Response_reg)
4 ALA A  74
ILE A  77
VAL A  63
ILE A  67
PG4  A 205 (-4.1A)
None
None
None
0.46A 1d4yB-3a0uA:
undetectable
1d4yB-3a0uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7m CELLULASE

(Rhodothermus
marinus)
PF01670
(Glyco_hydro_12)
4 LEU A   5
GLY A 196
VAL A  36
ILE A  34
None
0.70A 1d4yB-3b7mA:
undetectable
1d4yB-3b7mA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN


(Agrobacterium
fabrum)
PF07229
(VirE2)
4 LEU A 151
ILE A 265
VAL A 120
ILE A 118
None
0.69A 1d4yB-3btpA:
undetectable
1d4yB-3btpA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c24 PUTATIVE
OXIDOREDUCTASE


(Jannaschia sp.
CCS1)
PF03807
(F420_oxidored)
PF16896
(PGDH_C)
4 ALA A  39
GLY A  23
ILE A  26
ILE A  55
None
0.63A 1d4yB-3c24A:
undetectable
1d4yB-3c24A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg0 RESPONSE REGULATOR
RECEIVER MODULATED
DIGUANYLATE CYCLASE
WITH PAS/PAC SENSOR


(Desulfovibrio
alaskensis)
PF00072
(Response_reg)
4 LEU A  57
ILE A  25
VAL A  10
ILE A  12
None
0.63A 1d4yB-3cg0A:
undetectable
1d4yB-3cg0A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clj PROTEIN NRD1

(Saccharomyces
cerevisiae)
PF04818
(CTD_bind)
5 LEU A 108
GLY A  73
ILE A  72
VAL A 104
ILE A 105
None
1.08A 1d4yB-3cljA:
undetectable
1d4yB-3cljA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Cryptosporidium
parvum)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ALA A 271
GLY A 185
ILE A 186
VAL A 280
ILE A 276
None
1.29A 1d4yB-3cpsA:
undetectable
1d4yB-3cpsA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C)
5 LEU C  20
GLY C  97
ILE C 180
VAL C 101
ILE C   9
None
1.06A 1d4yB-3degC:
undetectable
1d4yB-3degC:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfy MUCONATE
CYCLOISOMERASE


(Thermotoga
maritima)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLY A 291
ILE A 290
VAL A 157
ILE A 186
None
0.66A 1d4yB-3dfyA:
undetectable
1d4yB-3dfyA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum)
PF00128
(Alpha-amylase)
4 LEU A 358
ILE A 298
VAL A 366
ILE A 368
None
0.68A 1d4yB-3dhuA:
undetectable
1d4yB-3dhuA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr5 PUTATIVE
O-METHYLTRANSFERASE


(Corynebacterium
glutamicum)
PF13578
(Methyltransf_24)
4 LEU A  45
ALA A  60
ILE A  63
ILE A  74
None
0.69A 1d4yB-3dr5A:
undetectable
1d4yB-3dr5A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE


(Escherichia
coli)
PF00464
(SHMT)
4 ALA A 333
GLY A 338
VAL A 364
ILE A 362
None
0.53A 1d4yB-3g8mA:
undetectable
1d4yB-3g8mA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609


(Methanocaldococcus
jannaschii)
PF13520
(AA_permease_2)
4 ALA C 296
GLY C 323
ILE C 326
VAL C 133
None
0.59A 1d4yB-3gi8C:
undetectable
1d4yB-3gi8C:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE


(Rauvolfia
serpentina)
PF00561
(Abhydrolase_1)
4 LEU A 258
ALA A 209
ILE A 104
ILE A 261
None
0.70A 1d4yB-3gzjA:
undetectable
1d4yB-3gzjA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE


(Deinococcus
radiodurans)
PF03275
(GLF)
PF13450
(NAD_binding_8)
5 LEU A 230
ALA A  49
ILE A 256
VAL A 237
ILE A 235
None
0.81A 1d4yB-3hdyA:
undetectable
1d4yB-3hdyA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA


(Bacillus
subtilis)
PF01510
(Amidase_2)
4 LEU A  47
ALA A  13
GLY A  18
ILE A   9
None
0.67A 1d4yB-3hmbA:
undetectable
1d4yB-3hmbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htn PUTATIVE DNA BINDING
PROTEIN


(Bacteroides
thetaiotaomicron)
PF03479
(DUF296)
4 LEU A 117
GLY A  89
ILE A 152
ILE A 114
None
0.67A 1d4yB-3htnA:
undetectable
1d4yB-3htnA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis)
PF00704
(Glyco_hydro_18)
4 LEU A 121
ASP A 158
GLY A 282
VAL A  79
None
0.71A 1d4yB-3ianA:
undetectable
1d4yB-3ianA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kal HOMOGLUTATHIONE
SYNTHETASE


(Glycine max)
PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP)
5 LEU A 234
ALA A 320
GLY A 280
VAL A 284
ILE A 289
None
1.33A 1d4yB-3kalA:
undetectable
1d4yB-3kalA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kly PUTATIVE FORMATE
TRANSPORTER 1


(Vibrio cholerae)
PF01226
(Form_Nir_trans)
4 GLY A 123
ILE A 126
VAL A  49
ILE A  46
None
0.68A 1d4yB-3klyA:
undetectable
1d4yB-3klyA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE


(Yersinia pestis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 ALA A 236
GLY A 277
ILE A 278
ILE A 239
None
0.71A 1d4yB-3kuxA:
undetectable
1d4yB-3kuxA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328


(Vibrio
vulnificus)
PF06500
(DUF1100)
5 ALA A 360
GLY A 270
ILE A 269
VAL A 356
ILE A 358
None
1.17A 1d4yB-3mveA:
undetectable
1d4yB-3mveA:
11.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
7 LEU A  23
ASP A  25
ALA A  28
GLY A  49
ILE A  50
VAL A  82
ILE A  84
None
0.61A 1d4yB-3mwsA:
19.5
1d4yB-3mwsA:
78.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN


(Paraburkholderia
xenovorans)
PF13458
(Peripla_BP_6)
5 ARG A  86
LEU A 112
ALA A 120
GLY A  30
ILE A 109
None
1.14A 1d4yB-3n0wA:
undetectable
1d4yB-3n0wA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE


(Vibrio
vulnificus)
PF02784
(Orn_Arg_deC_N)
4 LEU A  99
GLY A 203
VAL A 339
ILE A 341
None
0.56A 1d4yB-3n2oA:
undetectable
1d4yB-3n2oA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica)
PF13520
(AA_permease_2)
4 ALA A 235
GLY A 230
ILE A 229
ILE A  23
None
0.70A 1d4yB-3ncyA:
undetectable
1d4yB-3ncyA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Vibrio cholerae)
PF00275
(EPSP_synthase)
4 ALA A 132
GLY A 127
ILE A 126
ILE A 165
None
0.65A 1d4yB-3nvsA:
undetectable
1d4yB-3nvsA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE


(Oryctolagus
cuniculus)
PF00365
(PFK)
4 LEU A 711
ILE A 425
VAL A 523
ILE A 525
None
0.71A 1d4yB-3o8lA:
undetectable
1d4yB-3o8lA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot6 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Pseudomonas
syringae group
genomosp. 3)
PF00378
(ECH_1)
4 LEU A 143
ALA A 107
GLY A  60
ILE A  26
None
0.67A 1d4yB-3ot6A:
undetectable
1d4yB-3ot6A:
17.57