SIMILAR PATTERNS OF AMINO ACIDS FOR 1D4F_D_ADND604

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1g7r	TRANSLATION INITIATION FACTOR IF2/EIF5B (Methanothermobacter thermautotrophicus)	PF00009 (GTP_EFTU) PF03144 (GTP_EFTU_D2) PF11987 (IF-2) PF14578 (GTP_EFTU_D4)	5	LEU A 161 ASP A 162 ASP A 183 MET A 147 PHE A 146	None	1.23A	1d4fD-1g7rA: 2.9	1d4fD-1g7rA: 22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1gju	MALTODEXTRIN GLYCOSYLTRANSFERASE (Thermotoga maritima)	PF00128 (Alpha-amylase) PF09083 (DUF1923)	5	LEU A 335 HIS A 327 GLU A 329 ASP A 346 GLY A 355	None	1.29A	1d4fD-1gjuA: 0.4	1d4fD-1gjuA: 22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1i1q	ANTHRANILATE SYNTHASE COMPONENT I (Salmonella enterica)	PF00425 (Chorismate_bind) PF04715 (Anth_synt_I_N)	5	LEU A   8 THR A 199 LEU A 130 LEU A  80 GLY A  77	None	1.29A	1d4fD-1i1qA: undetectable	1d4fD-1i1qA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1jae	ALPHA-AMYLASE (Tenebrio molitor)	PF00128 (Alpha-amylase) PF02806 (Alpha-amylase_C)	5	HIS A  99 ASP A 185 LEU A 150 LEU A 153 GLY A 102	None	1.10A	1d4fD-1jaeA: undetectable	1d4fD-1jaeA: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1jxk	ALPHA-AMYLASE, SALIVARY (Homo sapiens)	PF00128 (Alpha-amylase) PF02806 (Alpha-amylase_C)	5	HIS A 101 ASP A 197 LEU A 162 LEU A 165 GLY A 104	None	1.07A	1d4fD-1jxkA: 0.7	1d4fD-1jxkA: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1lki	LEUKEMIA INHIBITORY FACTOR (Mus musculus)	PF01291 (LIF_OSM)	5	LEU A  83 GLU A  76 LEU A 130 LEU A 133 PHE A 180	None	1.48A	1d4fD-1lkiA: undetectable	1d4fD-1lkiA: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1p0n	ISOPENTENYL-DIPHOSPH ATE DELTA-ISOMERASE (Bacillus subtilis)	PF01070 (FMN_dh)	5	LEU A 242 THR A  23 ASP A 207 LEU A 260 GLY A 258	None None None None FMN  A 669 (-3.0A)	1.20A	1d4fD-1p0nA: 0.0	1d4fD-1p0nA: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1pzs	SUPEROXIDE DISMUTASE [CU-ZN] (Mycobacterium tuberculosis)	PF00080 (Sod_Cu)	5	THR A 107 LEU A  46 LEU A  90 GLY A  88 PHE A  22	None	0.93A	1d4fD-1pzsA: undetectable	1d4fD-1pzsA: 18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1r4n	UBIQUITIN-ACTIVATING ENZYME E1C (Homo sapiens)	PF00899 (ThiF) PF08825 (E2_bind)	5	THR B 182 ASP B 179 LEU B  63 LEU B  59 GLY B  58	None	1.47A	1d4fD-1r4nB: 4.6	1d4fD-1r4nB: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1suv	TRANSFERRIN RECEPTOR PROTEIN 1 (Homo sapiens)	PF02225 (PA) PF04253 (TFR_dimer) PF04389 (Peptidase_M28)	5	GLU A 728 LEU A 639 LEU A 637 GLY A 636 PHE A 726	None	1.48A	1d4fD-1suvA: 2.9	1d4fD-1suvA: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1u2l	PEROXIDASE/CATALASE HPI (Escherichia coli)	PF00141 (peroxidase)	5	LEU A 571 THR A 564 LEU A 492 GLY A 489 PHE A 569	None	1.46A	1d4fD-1u2lA: undetectable	1d4fD-1u2lA: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1um8	ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX (Helicobacter pylori)	PF07724 (AAA_2) PF10431 (ClpB_D2-small)	5	LEU A 241 GLU A 246 LEU A 146 LEU A 334 GLY A 332	None	1.44A	1d4fD-1um8A: undetectable	1d4fD-1um8A: 23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1usv	HEAT SHOCK PROTEIN HSP82 (Saccharomyces cerevisiae)	PF00183 (HSP90)	5	LEU A 499 LYS A 426 LEU A 479 GLY A 476 PHE A 510	None	1.38A	1d4fD-1usvA: undetectable	1d4fD-1usvA: 22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1v8b	ADENOSYLHOMOCYSTEINA SE (Plasmodium falciparum)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	HIS A  54 ASP A 134 LYS A 230 ASP A 234 LEU A 392	ADN  A 502 (-4.1A) ADN  A 502 (-3.1A) ADN  A 502 (-3.0A) ADN  A 502 (-2.8A) ADN  A 502 ( 4.9A)	1.37A	1d4fD-1v8bA: 54.0	1d4fD-1v8bA: 52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1v8b	ADENOSYLHOMOCYSTEINA SE (Plasmodium falciparum)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	12	LEU A  53 HIS A  54 THR A  56 GLU A  58 ASP A 134 LYS A 230 ASP A 234 LEU A 389 LEU A 392 GLY A 397 MET A 403 PHE A 407	None ADN  A 502 (-4.1A) ADN  A 502 (-3.0A) ADN  A 502 (-3.6A) ADN  A 502 (-3.1A) ADN  A 502 (-3.0A) ADN  A 502 (-2.8A) NAD  A 501 ( 3.8A) ADN  A 502 ( 4.9A) ADN  A 502 ( 3.7A) ADN  A 502 (-3.6A) None	0.36A	1d4fD-1v8bA: 54.0	1d4fD-1v8bA: 52.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1xeb	HYPOTHETICAL PROTEIN PA0115 (Pseudomonas aeruginosa)	PF13673 (Acetyltransf_10)	5	LEU A 101 LEU A  52 LEU A  64 GLY A  79 PHE A 130	None	1.43A	1d4fD-1xebA: undetectable	1d4fD-1xebA: 14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1y23	HISTIDINE TRIAD PROTEIN (Bacillus subtilis)	PF01230 (HIT)	5	LEU A  43 HIS A 104 ASP A  33 GLY A  95 PHE A   9	None	1.32A	1d4fD-1y23A: undetectable	1d4fD-1y23A: 16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1zr6	GLUCOOLIGOSACCHARIDE OXIDASE (Sarocladium strictum)	PF01565 (FAD_binding_4) PF08031 (BBE)	5	HIS A 127 THR A 113 LEU A 110 GLY A 134 PHE A 200	None None None FAD  A 501 (-3.3A) None	1.49A	1d4fD-1zr6A: undetectable	1d4fD-1zr6A: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1zr6	GLUCOOLIGOSACCHARIDE OXIDASE (Sarocladium strictum)	PF01565 (FAD_binding_4) PF08031 (BBE)	5	LEU A 125 HIS A 127 THR A 113 LEU A 110 GLY A 134	None None None None FAD  A 501 (-3.3A)	1.33A	1d4fD-1zr6A: undetectable	1d4fD-1zr6A: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2b4w	HYPOTHETICAL PROTEIN, CONSERVED (Leishmania major)	PF08950 (DUF1861)	5	LEU A  62 LYS A  40 LEU A 122 GLY A 117 PHE A  37	None	1.46A	1d4fD-2b4wA: undetectable	1d4fD-2b4wA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2cic	DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (Campylobacter jejuni)	PF08761 (dUTPase_2)	5	LEU A  50 LEU A 168 LEU A 163 GLY A 162 PHE A  54	None	1.45A	1d4fD-2cicA: undetectable	1d4fD-2cicA: 20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2cul	GLUCOSE-INHIBITED DIVISION PROTEIN A-RELATED PROTEIN, PROBABLE OXIDOREDUCTASE (Thermus thermophilus)	PF01134 (GIDA)	5	LEU A 195 LEU A  96 LEU A  94 GLY A  93 PHE A 183	None	1.23A	1d4fD-2culA: 3.2	1d4fD-2culA: 18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ei8	COAGULATION FACTOR X, HEAVY CHAIN (Homo sapiens)	PF00089 (Trypsin)	5	LEU A 155 THR A  73 ASP A 194 LEU A  32 GLY A  40	None	1.39A	1d4fD-2ei8A: undetectable	1d4fD-2ei8A: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2gv9	DNA POLYMERASE (Human alphaherpesvirus 1)	PF00136 (DNA_pol_B) PF03104 (DNA_pol_B_exo1)	5	LEU A 359 HIS A 148 GLU A 460 GLY A 186 PHE A 461	None	1.44A	1d4fD-2gv9A: undetectable	1d4fD-2gv9A: 17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2h56	DNA-3-METHYLADENINE GLYCOSIDASE (Bacillus halodurans)	PF00730 (HhH-GPD)	5	LEU A 195 LEU A 179 LEU A 160 MET A 141 PHE A 145	None	1.37A	1d4fD-2h56A: undetectable	1d4fD-2h56A: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2i1s	HYPOTHETICAL PROTEIN (Methanosarcina mazei)	PF07929 (PRiA4_ORF3)	5	HIS A  38 GLU A  54 ASP A  49 LEU A  35 GLY A  69	None	1.21A	1d4fD-2i1sA: undetectable	1d4fD-2i1sA: 15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2it1	362AA LONG HYPOTHETICAL MALTOSE/MALTODEXTRIN TRANSPORT ATP-BINDING PROTEIN (Pyrococcus horikoshii)	PF00005 (ABC_tran)	5	LEU A 157 LEU A 164 LEU A 161 MET A 200 PHE A  31	None	1.24A	1d4fD-2it1A: undetectable	1d4fD-2it1A: 24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ols	PHOSPHOENOLPYRUVATE SYNTHASE (Neisseria meningitidis)	PF00391 (PEP-utilizers) PF01326 (PPDK_N) PF02896 (PEP-utilizers_C)	5	LEU A  34 HIS A 310 GLU A 308 GLY A 312 MET A 315	None	1.33A	1d4fD-2olsA: undetectable	1d4fD-2olsA: 21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2reb	REC A (Escherichia coli)	PF00154 (RecA)	5	LEU A 263 GLU A 273 LYS A 310 LEU A 107 GLY A  43	None	1.14A	1d4fD-2rebA: undetectable	1d4fD-2rebA: 24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2vzb	PUTATIVE BACTERIOFERRITIN-REL ATED PROTEIN (Bacteroides fragilis)	PF00210 (Ferritin)	5	LEU A   9 GLU A  77 ASP A 132 LEU A  22 GLY A  78	None	1.23A	1d4fD-2vzbA: undetectable	1d4fD-2vzbA: 16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2vzw	PROBABLE HISTIDINE KINASE RESPONSE REGULATOR (Mycobacterium tuberculosis)	PF13185 (GAF_2)	5	LEU A  76 GLU A  99 LEU A 154 LEU A 170 GLY A  82	None None None None HEM  A1206 (-4.0A)	1.20A	1d4fD-2vzwA: undetectable	1d4fD-2vzwA: 19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yh0	SPLICING FACTOR U2AF 65 KDA SUBUNIT (Homo sapiens)	PF00076 (RRM_1)	5	LEU A 279 LEU A 325 LEU A 266 GLY A 301 PHE A 288	None	1.27A	1d4fD-2yh0A: undetectable	1d4fD-2yh0A: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yoc	PULLULANASE (Klebsiella oxytoca)	PF02922 (CBM_48) PF03714 (PUD) PF11852 (DUF3372)	5	ASP A 822 ASP A 590 LEU A 666 GLY A 693 PHE A 862	None	1.31A	1d4fD-2yocA: undetectable	1d4fD-2yocA: 16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3bw2	2-NITROPROPANE DIOXYGENASE (Streptomyces ansochromogenes)	PF03060 (NMO)	5	THR A 243 GLU A 245 LEU A 340 LEU A 336 GLY A 334	None	1.26A	1d4fD-3bw2A: undetectable	1d4fD-3bw2A: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3byd	BETA-LACTAMASE OXY-1 (Klebsiella oxytoca)	PF13354 (Beta-lactamase2)	5	THR A 197 ASP A 248 LEU A 130 LEU A 214 GLY A 235	None	1.41A	1d4fD-3bydA: undetectable	1d4fD-3bydA: 21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ce6	ADENOSYLHOMOCYSTEINA SE (Mycobacterium tuberculosis)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	HIS A  69 ASP A 156 LYS A 248 ASP A 252 LEU A 410	ADN  A 500 (-4.0A) ADN  A 500 (-2.9A) ADN  A 500 (-2.8A) ADN  A 500 (-2.7A) ADN  A 500 ( 4.8A)	1.45A	1d4fD-3ce6A: 54.7	1d4fD-3ce6A: 54.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ce6	ADENOSYLHOMOCYSTEINA SE (Mycobacterium tuberculosis)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	11	LEU A  68 HIS A  69 THR A  71 ASP A 156 LYS A 248 ASP A 252 LEU A 407 LEU A 410 GLY A 415 MET A 421 PHE A 425	None ADN  A 500 (-4.0A) ADN  A 500 (-2.8A) ADN  A 500 (-2.9A) ADN  A 500 (-2.8A) ADN  A 500 (-2.7A) NAD  A 550 (-4.2A) ADN  A 500 ( 4.8A) ADN  A 500 ( 3.6A) ADN  A 500 (-3.7A) ADN  A 500 (-4.8A)	0.54A	1d4fD-3ce6A: 54.7	1d4fD-3ce6A: 54.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cmu	PROTEIN RECA (Escherichia coli)	PF00154 (RecA)	5	LEU A 263 GLU A 273 LYS A 310 LEU A 107 GLY A  43	None	1.28A	1d4fD-3cmuA: undetectable	1d4fD-3cmuA: 12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cmu	PROTEIN RECA (Escherichia coli)	PF00154 (RecA)	5	LEU A1263 GLU A1273 LYS A1310 LEU A1107 GLY A1043	None	1.24A	1d4fD-3cmuA: undetectable	1d4fD-3cmuA: 12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cmu	PROTEIN RECA (Escherichia coli)	PF00154 (RecA)	5	LEU A2263 GLU A2273 LYS A2310 LEU A2107 GLY A2043	None	1.23A	1d4fD-3cmuA: undetectable	1d4fD-3cmuA: 12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cmu	PROTEIN RECA (Escherichia coli)	PF00154 (RecA)	5	LEU A3263 GLU A3273 LYS A3310 LEU A3107 GLY A3043	None	1.25A	1d4fD-3cmuA: undetectable	1d4fD-3cmuA: 12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cmu	PROTEIN RECA (Escherichia coli)	PF00154 (RecA)	5	LEU A4263 GLU A4273 LYS A4310 LEU A4107 GLY A4043	None	1.24A	1d4fD-3cmuA: undetectable	1d4fD-3cmuA: 12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cmu	PROTEIN RECA (Escherichia coli)	PF00154 (RecA)	5	LEU A5263 GLU A5273 LYS A5310 LEU A5107 GLY A5043	None	1.30A	1d4fD-3cmuA: undetectable	1d4fD-3cmuA: 12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cmv	PROTEIN RECA (Escherichia coli)	PF00154 (RecA)	5	LEU A 263 GLU A 273 LYS A 310 LEU A 107 GLY A  43	None	1.30A	1d4fD-3cmvA: undetectable	1d4fD-3cmvA: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dob	HEAT SHOCK 70 KDA PROTEIN F44E5.5 (Caenorhabditis elegans)	PF00012 (HSP70)	5	HIS A 455 LYS A 512 LEU A 457 GLY A 446 MET A 519	None	1.18A	1d4fD-3dobA: undetectable	1d4fD-3dobA: 15.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3g1u	ADENOSYLHOMOCYSTEINA SE (Leishmania major)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	9	LEU A  51 HIS A  52 THR A  54 ASP A 130 LEU A 343 LEU A 346 GLY A 351 MET A 357 PHE A 361	None ADN  A 438 (-4.0A) ADN  A 438 (-2.8A) ADN  A 438 (-4.1A) NAD  A 439 ( 4.0A) ADN  A 438 ( 4.8A) ADN  A 438 ( 3.8A) ADN  A 438 (-3.7A) None	0.68A	1d4fD-3g1uA: 59.6	1d4fD-3g1uA: 71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3glq	ADENOSYLHOMOCYSTEINA SE (Burkholderia pseudomallei)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	HIS A  62 ASP A 139 LYS A 229 ASP A 233 LEU A 388	RAB  A 602 (-3.8A) RAB  A 602 (-3.0A) RAB  A 602 (-3.0A) RAB  A 602 (-2.5A) RAB  A 602 ( 4.7A)	1.46A	1d4fD-3glqA: 56.9	1d4fD-3glqA: 56.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3glq	ADENOSYLHOMOCYSTEINA SE (Burkholderia pseudomallei)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	11	LEU A  61 HIS A  62 THR A  64 ASP A 139 LYS A 229 ASP A 233 LEU A 385 LEU A 388 GLY A 393 MET A 399 PHE A 403	None RAB  A 602 (-3.8A) RAB  A 602 (-2.7A) RAB  A 602 (-3.0A) RAB  A 602 (-3.0A) RAB  A 602 (-2.5A) NAD  A 601 ( 4.1A) RAB  A 602 ( 4.7A) RAB  A 602 ( 3.8A) RAB  A 602 (-3.6A) None	0.50A	1d4fD-3glqA: 56.9	1d4fD-3glqA: 56.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3h9u	ADENOSYLHOMOCYSTEINA SE (Trypanosoma brucei)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	HIS A  52 ASP A 130 LYS A 185 ASP A 189 LEU A 343	ADN  A 439 ( 4.7A) None NAD  A 438 ( 3.9A) NAD  A 438 ( 4.4A) NAD  A 438 (-4.0A)	1.36A	1d4fD-3h9uA: 61.5	1d4fD-3h9uA: 71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3h9u	ADENOSYLHOMOCYSTEINA SE (Trypanosoma brucei)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	11	LEU A  51 HIS A  52 THR A  54 ASP A 130 LYS A 185 ASP A 189 LEU A 343 LEU A 346 GLY A 351 MET A 357 PHE A 361	None ADN  A 439 ( 4.7A) ADN  A 439 (-2.7A) None NAD  A 438 ( 3.9A) NAD  A 438 ( 4.4A) NAD  A 438 (-4.0A) ADN  A 439 ( 4.7A) ADN  A 439 (-3.5A) ADN  A 439 ( 3.7A) None	0.37A	1d4fD-3h9uA: 61.5	1d4fD-3h9uA: 71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3k9c	TRANSCRIPTIONAL REGULATOR, LACI FAMILY PROTEIN (Rhodococcus jostii)	PF13377 (Peripla_BP_3)	5	ASP A 280 ASP A 169 LEU A  88 GLY A 133 PHE A 251	GOL  A 349 (-2.8A) None None None None	1.20A	1d4fD-3k9cA: undetectable	1d4fD-3k9cA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ld2	PUTATIVE ACETYLTRANSFERASE (Streptococcus mutans)	PF00583 (Acetyltransf_1)	5	LEU A 101 LEU A  50 LEU A  62 GLY A  80 PHE A 131	None None None COA  A 164 ( 4.4A) None	1.40A	1d4fD-3ld2A: undetectable	1d4fD-3ld2A: 17.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3n58	ADENOSYLHOMOCYSTEINA SE (Brucella abortus)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	11	LEU A  54 HIS A  55 THR A  57 ASP A 132 LYS A 222 ASP A 226 LEU A 378 LEU A 381 GLY A 386 MET A 392 PHE A 396	None ADN  A 500 (-4.0A) ADN  A 500 (-2.8A) ADN  A 500 (-3.3A) ADN  A 500 (-2.7A) ADN  A 500 ( 2.6A) NAD  A 550 (-4.3A) ADN  A 500 ( 4.8A) ADN  A 500 (-3.7A) ADN  A 500 (-3.7A) None	0.47A	1d4fD-3n58A: 56.7	1d4fD-3n58A: 58.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o65	PUTATIVE ATAXIN-3-LIKE PROTEIN (Homo sapiens)	PF02099 (Josephin)	5	LEU A 179 HIS A 130 LEU A 143 MET A   2 PHE A   4	None	1.20A	1d4fD-3o65A: undetectable	1d4fD-3o65A: 17.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3one	ADENOSYLHOMOCYSTEINA SE (Lupinus luteus)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	HIS A  62 ASP A 139 LYS A 235 ASP A 239 LEU A 395	ADE  A 506 (-4.6A) None NAD  A 501 ( 4.2A) NAD  A 501 ( 4.5A) NAD  A 501 (-4.2A)	1.34A	1d4fD-3oneA: 53.7	1d4fD-3oneA: 57.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3one	ADENOSYLHOMOCYSTEINA SE (Lupinus luteus)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	10	HIS A  62 THR A  64 ASP A 139 LYS A 235 ASP A 239 LEU A 395 LEU A 398 GLY A 403 MET A 409 PHE A 413	ADE  A 506 (-4.6A) ADE  A 506 (-2.8A) None NAD  A 501 ( 4.2A) NAD  A 501 ( 4.5A) NAD  A 501 (-4.2A) ADE  A 506 ( 4.7A) ADE  A 506 ( 3.6A) ADE  A 506 (-3.8A) ADE  A 506 (-4.9A)	0.42A	1d4fD-3oneA: 53.7	1d4fD-3oneA: 57.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3one	ADENOSYLHOMOCYSTEINA SE (Lupinus luteus)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	10	LEU A  61 THR A  64 ASP A 139 LYS A 235 ASP A 239 LEU A 395 LEU A 398 GLY A 403 MET A 409 PHE A 413	None ADE  A 506 (-2.8A) None NAD  A 501 ( 4.2A) NAD  A 501 ( 4.5A) NAD  A 501 (-4.2A) ADE  A 506 ( 4.7A) ADE  A 506 ( 3.6A) ADE  A 506 (-3.8A) ADE  A 506 (-4.9A)	0.62A	1d4fD-3oneA: 53.7	1d4fD-3oneA: 57.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3qy7	TYROSINE-PROTEIN PHOSPHATASE YWQE (Bacillus subtilis)	no annotation	5	HIS A   5 ASP A 194 ASP A  13 LEU A 106 GLY A  78	FE  A 264 (-3.3A) FE  A 264 ( 2.6A) None None None	1.41A	1d4fD-3qy7A: undetectable	1d4fD-3qy7A: 21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3r38	UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE 1 (Listeria monocytogenes)	PF00275 (EPSP_synthase)	5	LEU A 406 GLU A 235 LEU A 392 LEU A 395 PHE A 239	None	1.45A	1d4fD-3r38A: undetectable	1d4fD-3r38A: 23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3sgi	DNA LIGASE (Mycobacterium tuberculosis)	PF01653 (DNA_ligase_aden) PF03120 (DNA_ligase_OB)	5	LEU A 269 HIS A 250 THR A 267 GLU A 121 LEU A 254	None None None AMP  A 616 ( 3.9A) None	1.33A	1d4fD-3sgiA: undetectable	1d4fD-3sgiA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3sig	POLY(ADP-RIBOSE) GLYCOHYDROLASE (Thermomonospora curvata)	PF10021 (DUF2263)	5	LEU A  94 THR A  76 LEU A 123 LEU A 117 GLY A 116	None AR6  A 280 (-4.3A) None None None	1.14A	1d4fD-3sigA: undetectable	1d4fD-3sigA: 22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3swv	BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2 (Homo sapiens)	PF01369 (Sec7)	5	LEU A 682 GLU A 676 LEU A 665 LEU A 671 GLY A 672	None	1.37A	1d4fD-3swvA: undetectable	1d4fD-3swvA: 19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3umm	PHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE (Salmonella enterica)	PF02769 (AIRS_C) PF13507 (GATase_5)	5	LEU A 981 GLU A 896 LEU A 920 LEU A 891 PHE A 899	None MG  A2007 ( 4.1A) None None None	1.42A	1d4fD-3ummA: 4.3	1d4fD-3ummA: 16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4boc	DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL (Homo sapiens)	PF00940 (RNA_pol) PF14700 (RPOL_N)	5	LEU A1127 HIS A1175 LEU A1219 GLY A 935 PHE A1123	None	1.44A	1d4fD-4bocA: undetectable	1d4fD-4bocA: 16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4bvx	EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1 (Homo sapiens)	PF00043 (GST_C)	5	THR B 114 GLU B  67 LEU B 102 GLY B 110 MET B  70	None	1.45A	1d4fD-4bvxB: undetectable	1d4fD-4bvxB: 17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4cw4	BETA-KETOACYL SYNTHASE (Pseudomonas aeruginosa)	PF00109 (ketoacyl-synt) PF02801 (Ketoacyl-synt_C)	5	HIS A  23 ASP A 581 ASP A 196 GLY A  17 PHE A  10	None	1.19A	1d4fD-4cw4A: undetectable	1d4fD-4cw4A: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4iv9	TRYPTOPHAN 2-MONOOXYGENASE (Pseudomonas savastanoi)	PF01593 (Amino_oxidase)	5	GLU A  69 LEU A 281 LEU A  51 GLY A  47 PHE A 297	FAD  A 601 (-2.8A) None None FAD  A 601 (-3.6A) None	1.41A	1d4fD-4iv9A: 3.6	1d4fD-4iv9A: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4iv9	TRYPTOPHAN 2-MONOOXYGENASE (Pseudomonas savastanoi)	PF01593 (Amino_oxidase)	5	LEU A 396 THR A 383 LEU A 411 GLY A 392 PHE A 121	None	1.36A	1d4fD-4iv9A: 3.6	1d4fD-4iv9A: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4jcc	IRON-COMPOUND ABC TRANSPORTER, IRON-COMPOUND-BINDIN G PROTEIN (Streptococcus pneumoniae)	PF01497 (Peripla_BP_2)	5	LEU A 262 GLU A 205 ASP A 272 LEU A 203 GLY A 206	None	1.47A	1d4fD-4jccA: undetectable	1d4fD-4jccA: 21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lvc	S-ADENOSYL-L-HOMOCYS TEINE HYDROLASE (SAHASE) (Bradyrhizobium elkanii)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	11	LEU A  57 HIS A  58 THR A  60 ASP A 135 LYS A 227 ASP A 231 LEU A 383 LEU A 386 GLY A 391 MET A 397 PHE A 401	None ADN  A 501 (-4.0A) ADN  A 501 (-2.8A) ADN  A 501 (-3.0A) ADN  A 501 (-2.7A) ADN  A 501 (-3.1A) NAD  A 503 ( 3.9A) ADN  A 501 ( 4.7A) ADN  A 501 (-3.6A) ADN  A 501 (-3.7A) ADN  A 501 (-4.8A)	0.38A	1d4fD-4lvcA: 56.5	1d4fD-4lvcA: 58.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4q9t	NUCLEOPORIN NUP133 (Vanderwaltozyma polyspora)	PF08801 (Nucleoporin_N)	5	THR A  79 ASP A 104 LEU A  84 LEU A  81 GLY A 490	None	1.19A	1d4fD-4q9tA: undetectable	1d4fD-4q9tA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4qiw	DNA-DIRECTED RNA POLYMERASE (Thermococcus kodakarensis)	PF00562 (RNA_pol_Rpb2_6) PF00623 (RNA_pol_Rpb1_2) PF04560 (RNA_pol_Rpb2_7) PF04561 (RNA_pol_Rpb2_2) PF04563 (RNA_pol_Rpb2_1) PF04565 (RNA_pol_Rpb2_3) PF04566 (RNA_pol_Rpb2_4) PF04567 (RNA_pol_Rpb2_5) PF04983 (RNA_pol_Rpb1_3) PF04997 (RNA_pol_Rpb1_1) PF04998 (RNA_pol_Rpb1_5) PF05000 (RNA_pol_Rpb1_4)	5	LEU B1073 HIS A  73 LYS B1102 ASP B1106 GLY A  75	None ZN  A1002 (-3.1A) None None None	1.37A	1d4fD-4qiwB: undetectable	1d4fD-4qiwB: 17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4s05	DNA-BINDING TRANSCRIPTIONAL REGULATOR BASR (Klebsiella pneumoniae)	PF00072 (Response_reg) PF00486 (Trans_reg_C)	5	LEU A  54 GLU A  35 LEU A  16 LEU A  13 GLY A  29	None	1.38A	1d4fD-4s05A: 2.9	1d4fD-4s05A: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4u09	LIC12759 (Leptospira interrogans)	PF13855 (LRR_8)	5	LEU A 276 LEU A 319 LEU A 316 GLY A 291 PHE A 263	None	1.44A	1d4fD-4u09A: undetectable	1d4fD-4u09A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4uml	GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSO CIATED PROTEIN 2 (Homo sapiens)	PF01661 (Macro)	5	HIS A 127 GLU A 111 LEU A 101 LEU A  79 GLY A 106	None	1.41A	1d4fD-4umlA: undetectable	1d4fD-4umlA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xko	HEAT SHOCK COGNATE 90 KDA PROTEIN (Dictyostelium discoideum)	PF00183 (HSP90) PF02518 (HATPase_c)	5	LEU A 133 THR A  25 ASP A 117 LEU A  18 LEU A  21	None	1.45A	1d4fD-4xkoA: undetectable	1d4fD-4xkoA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ziu	UNCHARACTERIZED LIPOPROTEIN YFHM (Escherichia coli)	PF07678 (A2M_comp)	5	LEU A1188 THR A1254 GLU A1249 LEU A1231 GLY A1238	None	1.47A	1d4fD-4ziuA: undetectable	1d4fD-4ziuA: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dp2	CURF (Lyngbya majuscula)	PF08240 (ADH_N) PF13602 (ADH_zinc_N_2)	5	GLU A 279 LEU A 294 LEU A 290 MET A 276 PHE A 274	None None None NAP  A 401 (-4.9A) None	1.45A	1d4fD-5dp2A: 5.2	1d4fD-5dp2A: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5fqd	DNA DAMAGE-BINDING PROTEIN 1 (Homo sapiens)	PF03178 (CPSF_A) PF10433 (MMS1_N)	5	THR A1032 ASP A1092 LEU A 974 LEU A1000 GLY A1001	None	1.35A	1d4fD-5fqdA: undetectable	1d4fD-5fqdA: 19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5h0r	VP4 PROTEIN (Cypovirus 1)	no annotation	5	LEU G 551 HIS G 296 LEU G 273 GLY G 297 PHE G 362	None	1.39A	1d4fD-5h0rG: undetectable	1d4fD-5h0rG: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ht0	AMINOGLYCOSIDE ACETYLTRANSFERASE HMB0005 (uncultured bacterium)	PF02522 (Antibiotic_NAT)	5	LEU A  60 GLU A 124 LEU A  20 GLY A  23 PHE A 128	None	1.40A	1d4fD-5ht0A: undetectable	1d4fD-5ht0A: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5kwa	PROTEASOME-ASSOCIATE D ATPASE (Mycobacterium tuberculosis)	PF00004 (AAA) PF16450 (Prot_ATP_ID_OB)	5	LEU A 396 LEU A 426 LEU A 431 GLY A 288 PHE A 353	None	1.39A	1d4fD-5kwaA: undetectable	1d4fD-5kwaA: 22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5liq	NICKING ENDONUCLEASE N.BSPD6I (Bacillus sp. (in: Bacteria))	PF09491 (RE_AlwI)	5	LEU A 539 LEU A 545 LEU A 546 GLY A 424 PHE A 417	None	1.45A	1d4fD-5liqA: 2.0	1d4fD-5liqA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5oko	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2 (Homo sapiens)	PF03372 (Exo_endo_phos)	5	LEU A 823 LEU A 774 LEU A 806 MET A 870 PHE A 852	None	1.48A	1d4fD-5okoA: undetectable	1d4fD-5okoA: 19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5tjz	4-HYDROXY-TETRAHYDRO DIPICOLINATE REDUCTASE (Mycobacterium tuberculosis)	no annotation	5	LEU A 212 ASP A 210 LEU A 131 LEU A 190 GLY A 189	None AE3  A 305 (-3.6A) None None None	1.49A	1d4fD-5tjzA: 7.1	1d4fD-5tjzA: 11.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5tov	ADENOSYLHOMOCYSTEINA SE (Thermotoga maritima)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	HIS A 123 THR A 124 ASP A 113 LEU A 156 LEU A 150	None	1.19A	1d4fD-5tovA: 28.0	1d4fD-5tovA: 40.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u70	POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 (Gallus gallus)	PF03493 (BK_channel_a) PF07885 (Ion_trans_2)	5	LEU A 496 GLU A 489 LEU A 809 LEU A 787 GLY A 784	None	1.42A	1d4fD-5u70A: 2.1	1d4fD-5u70A: 15.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5utu	ADENOSYLHOMOCYSTEINA SE (Cryptosporidium parvum)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	12	LEU A  52 HIS A  53 THR A  55 GLU A  57 ASP A 137 LYS A 241 ASP A 245 LEU A 401 LEU A 404 GLY A 409 MET A 415 PHE A 419	None SAH  A 502 (-4.0A) SAH  A 502 (-2.7A) SAH  A 502 (-3.7A) SAH  A 502 (-3.4A) SAH  A 502 (-2.9A) SAH  A 502 (-2.8A) NAD  A 501 (-4.1A) SAH  A 502 ( 4.7A) SAH  A 502 ( 3.7A) SAH  A 502 (-3.6A) SAH  A 502 (-4.8A)	0.40A	1d4fD-5utuA: 51.5	1d4fD-5utuA: 48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5v96	S-ADENOSYL-L-HOMOCYS TEINE HYDROLASE (Naegleria fowleri)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	12	LEU A  58 HIS A  59 THR A  61 GLU A  63 ASP A 136 LYS A 227 ASP A 231 LEU A 386 LEU A 389 GLY A 394 MET A 400 PHE A 404	None ADN  A 502 ( 3.9A) ADN  A 502 (-2.9A) ADN  A 502 (-3.6A) ADN  A 502 (-2.9A) ADN  A 502 (-2.9A) ADN  A 502 (-2.8A) NAD  A 501 (-3.9A) ADN  A 502 ( 4.7A) ADN  A 502 (-3.7A) ADN  A 502 (-3.8A) ADN  A 502 (-4.9A)	0.36A	1d4fD-5v96A: 55.8	1d4fD-5v96A: 57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5w4b	ADENOSYLHOMOCYSTEINA SE (Homo sapiens)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	8	LEU A  54 HIS A  55 THR A  57 ASP A 131 LYS A 186 ASP A 190 MET A 358 PHE A 362	None 9W4  A 502 (-3.7A) 9W4  A 502 (-2.9A) None None NAD  A 501 (-4.1A) 9W4  A 502 (-3.6A) None	0.74A	1d4fD-5w4bA: 53.7	1d4fD-5w4bA: 96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5w4b	ADENOSYLHOMOCYSTEINA SE (Homo sapiens)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	8	LEU A  54 HIS A  55 THR A  57 GLU A  59 ASP A 131 LYS A 186 MET A 358 PHE A 362	None 9W4  A 502 (-3.7A) 9W4  A 502 (-2.9A) 9W4  A 502 (-3.8A) None None 9W4  A 502 (-3.6A) None	0.53A	1d4fD-5w4bA: 53.7	1d4fD-5w4bA: 96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5w4b	ADENOSYLHOMOCYSTEINA SE (Homo sapiens)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	LYS A 186 ASP A 190 GLY A 352 MET A 358 PHE A 362	None NAD  A 501 (-4.1A) 9W4  A 502 ( 3.9A) 9W4  A 502 (-3.6A) None	0.94A	1d4fD-5w4bA: 53.7	1d4fD-5w4bA: 96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5w4b	ADENOSYLHOMOCYSTEINA SE (Homo sapiens)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	6	LYS A 186 ASP A 190 LEU A 344 LEU A 347 GLY A 352 MET A 358	None NAD  A 501 (-4.1A) NAD  A 501 (-4.0A) 9W4  A 502 (-4.1A) 9W4  A 502 ( 3.9A) 9W4  A 502 (-3.6A)	0.98A	1d4fD-5w4bA: 53.7	1d4fD-5w4bA: 96.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5wql	TAIL-SPECIFIC PROTEASE (Escherichia coli)	no annotation	5	LEU C  85 GLU C 125 ASP C  79 LEU C 165 LEU C 162	None	1.28A	1d4fD-5wqlC: undetectable	1d4fD-5wqlC: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5yq5	OSTEOMODULIN (Homo sapiens)	no annotation	5	LEU A 193 LEU A 235 LEU A 214 MET A 182 PHE A 156	None	1.20A	1d4fD-5yq5A: undetectable	1d4fD-5yq5A: 10.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6aph	ADENOSYLHOMOCYSTEINA SE (Elizabethkingia anophelis)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	11	LEU A  57 HIS A  58 THR A  60 ASP A 136 LYS A 191 ASP A 195 LEU A 349 LEU A 352 GLY A 357 MET A 363 PHE A 367	None ADN  A 501 (-3.9A) ADN  A 501 (-2.8A) ADN  A 501 (-3.0A) ADN  A 501 (-2.8A) ADN  A 501 (-2.7A) NAD  A 500 ( 4.3A) ADN  A 501 ( 4.8A) ADN  A 501 (-3.6A) ADN  A 501 (-3.7A) None	0.50A	1d4fD-6aphA: 61.5	1d4fD-6aphA: 66.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6b3r	PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT 1 (Mus musculus)	no annotation	5	LEU A1746 LEU A1186 LEU A1185 GLY A1173 PHE A1749	None	1.42A	1d4fD-6b3rA: undetectable	1d4fD-6b3rA: 10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6f3m	- (-)	no annotation	10	HIS B  61 THR B  63 ASP B 139 LYS B 194 ASP B 198 LEU B 373 LEU B 376 GLY B 381 MET B 387 PHE B 391	ADN  B 502 ( 4.0A) ADN  B 502 (-2.8A) ZN  B 505 ( 2.5A) ADN  B 502 (-2.8A) ADN  B 502 (-2.7A) NAD  B 501 ( 3.9A) ADN  B 502 ( 4.8A) ADN  B 502 ( 3.7A) ADN  B 502 (-3.7A) ADN  B 502 (-4.9A)	0.45A	1d4fD-6f3mB: 55.2	1d4fD-6f3mB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6gbn	- (-)	no annotation	5	HIS A  56 ASP A 134 LYS A 189 ASP A 193 LEU A 347	ADN  A 501 (-3.9A) ADN  A 501 (-2.9A) ADN  A 501 (-2.9A) ADN  A 501 (-2.7A) NAD  A 502 (-3.9A)	1.35A	1d4fD-6gbnA: 61.6	1d4fD-6gbnA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6gbn	- (-)	no annotation	11	LEU A  55 HIS A  56 THR A  58 ASP A 134 LYS A 189 ASP A 193 LEU A 347 LEU A 350 GLY A 355 MET A 361 PHE A 365	None ADN  A 501 (-3.9A) ADN  A 501 (-2.8A) ADN  A 501 (-2.9A) ADN  A 501 (-2.9A) ADN  A 501 (-2.7A) NAD  A 502 (-3.9A) ADN  A 501 ( 4.7A) ADN  A 501 (-3.8A) ADN  A 501 (-3.6A) None	0.41A	1d4fD-6gbnA: 61.6	1d4fD-6gbnA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1h0h	FORMATE DEHYDROGENASE SUBUNIT ALPHA FORMATE DEHYDROGENASE SUBUNIT BETA (Desulfovibrio gigas)	PF00384 (Molybdopterin) PF01568 (Molydop_binding) PF04879 (Molybdop_Fe4S4) PF13247 (Fer4_11)	4	THR B  12 GLU A 197 HIS A 199 HIS A 218	SF4  B1011 (-4.3A) None MGD  A1002 ( 4.5A) None	1.37A	1d4fD-1h0hB: undetectable	1d4fD-1h0hB: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ml4	ASPARTATE TRANSCARBAMOYLASE (Pyrococcus abyssi)	PF00185 (OTCace) PF02729 (OTCace_N)	4	THR A 145 THR A 169 HIS A 135 HIS A 266	None PAL  A 385 ( 4.2A) PAL  A 385 (-3.9A) None	1.41A	1d4fD-1ml4A: 3.2	1d4fD-1ml4A: 23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1n8p	CYSTATHIONINE GAMMA-LYASE (Saccharomyces cerevisiae)	PF01053 (Cys_Met_Meta_PP)	4	THR A 106 GLU A 145 THR A 148 HIS A 350	None PLP  A 400 ( 4.7A) None None	1.02A	1d4fD-1n8pA: undetectable	1d4fD-1n8pA: 23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1qaf	PROTEIN (COPPER AMINE OXIDASE) (Escherichia coli)	PF01179 (Cu_amine_oxid) PF02727 (Cu_amine_oxidN2) PF02728 (Cu_amine_oxidN3) PF07833 (Cu_amine_oxidN1)	4	THR A 687 GLU A 702 THR A 701 HIS A 705	None	1.02A	1d4fD-1qafA: undetectable	1d4fD-1qafA: 23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1qxy	METHIONYL AMINOPEPTIDASE (Staphylococcus aureus)	PF00557 (Peptidase_M24)	4	GLU A 202 THR A 166 HIS A 180 HIS A  76	CO  A1001 ( 2.5A) None None M2C  A3001 ( 4.5A)	1.50A	1d4fD-1qxyA: undetectable	1d4fD-1qxyA: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1tf1	NEGATIVE REGULATOR OF ALLANTOIN AND GLYOXYLATE UTILIZATION OPERONS (Escherichia coli)	PF01614 (IclR)	4	THR A 120 GLU A 125 THR A 100 HIS A  67	None	1.41A	1d4fD-1tf1A: undetectable	1d4fD-1tf1A: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wyt	GLYCINE DEHYDROGENASE SUBUNIT 2 (P-PROTEIN) (Thermus thermophilus)	PF02347 (GDC-P)	4	THR B 403 GLU B 417 THR B 419 HIS B 272	None	1.28A	1d4fD-1wytB: 3.2	1d4fD-1wytB: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1yq2	BETA-GALACTOSIDASE (Arthrobacter sp. C2-2)	PF02836 (Glyco_hydro_2_C) PF02837 (Glyco_hydro_2_N) PF02929 (Bgal_small_N) PF16353 (DUF4981)	4	GLU A 336 THR A 337 HIS A 557 HIS A  84	None PEG  A9001 (-3.6A) PEG  A9001 (-4.5A) None	1.45A	1d4fD-1yq2A: 2.2	1d4fD-1yq2A: 17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2cj3	PLASTOCYANIN (Nostoc sp. PCC 7120)	PF00127 (Copper-bind)	4	THR A   2 GLU A  30 THR A  72 HIS A  61	None	1.36A	1d4fD-2cj3A: undetectable	1d4fD-2cj3A: 13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2d7s	RNA-DEPENDENT RNA POLYMERASE (Foot-and-mouth disease virus)	PF00680 (RdRP_1)	4	THR A 303 THR A 281 HIS A 283 HIS A 188	None	1.41A	1d4fD-2d7sA: undetectable	1d4fD-2d7sA: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2gef	PROTEASE VP4 (Blotched snakehead virus)	PF01768 (Birna_VP4)	4	GLU A 749 THR A 751 HIS A 762 HIS A 734	None	1.41A	1d4fD-2gefA: undetectable	1d4fD-2gefA: 18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2glf	PROBABLE M18-FAMILY AMINOPEPTIDASE 1 (Thermotoga maritima)	PF02127 (Peptidase_M18)	4	THR A 288 GLU A  35 THR A  38 HIS A  94	None None None MN  A5001 (-3.6A)	1.42A	1d4fD-2glfA: undetectable	1d4fD-2glfA: 23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2nsg	HYPOTHETICAL PROTEIN CGL3021 (Corynebacterium glutamicum)	PF11716 (MDMPI_N)	4	THR A 137 THR A  73 HIS A  65 HIS A 122	None	1.36A	1d4fD-2nsgA: undetectable	1d4fD-2nsgA: 20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2p0y	HYPOTHETICAL PROTEIN LP_0780 (Lactobacillus plantarum)	PF01933 (UPF0052)	4	GLU A 235 THR A 236 HIS A 244 HIS A 251	None	1.49A	1d4fD-2p0yA: 4.9	1d4fD-2p0yA: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2qed	HYDROXYACYLGLUTATHIO NE HYDROLASE (Salmonella enterica)	PF00753 (Lactamase_B) PF16123 (HAGH_C)	4	THR A 107 GLU A  79 THR A  80 HIS A  58	None None None FE  A 252 (-3.2A)	1.49A	1d4fD-2qedA: undetectable	1d4fD-2qedA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2z00	DIHYDROOROTASE (Thermus thermophilus)	PF01979 (Amidohydro_1)	4	GLU A 256 THR A 258 HIS A 261 HIS A  57	None None None ZN  A1004 (-3.4A)	1.36A	1d4fD-2z00A: undetectable	1d4fD-2z00A: 22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zu6	EUKARYOTIC INITIATION FACTOR 4A-I PROGRAMMED CELL DEATH PROTEIN 4 (Homo sapiens)	PF00270 (DEAD) PF00271 (Helicase_C) PF02847 (MA3)	4	THR B 169 GLU A 111 THR A 109 HIS B 215	None	1.30A	1d4fD-2zu6B: undetectable	1d4fD-2zu6B: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3axx	458AA LONG HYPOTHETICAL ENDO-1,4-BETA-GLUCAN ASE (Pyrococcus horikoshii)	PF00150 (Cellulase)	4	THR A 160 GLU A 163 HIS A 203 HIS A 155	None	1.38A	1d4fD-3axxA: undetectable	1d4fD-3axxA: 22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ce6	ADENOSYLHOMOCYSTEINA SE (Mycobacterium tuberculosis)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	THR A  74 GLU A 218 THR A 219 HIS A 363 HIS A 416	ADN  A 500 (-4.5A) ADN  A 500 (-2.6A) NAD  A 550 ( 2.8A) ADN  A 500 ( 3.7A) ADN  A 500 ( 3.6A)	0.78A	1d4fD-3ce6A: 54.7	1d4fD-3ce6A: 54.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3g1u	ADENOSYLHOMOCYSTEINA SE (Leishmania major)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	THR A  57 GLU A 155 THR A 156 HIS A 300 HIS A 352	ADN  A 438 (-4.6A) ADN  A 438 (-3.8A) NAD  A 439 ( 3.0A) ADN  A 438 ( 4.0A) ADN  A 438 ( 3.6A)	0.67A	1d4fD-3g1uA: 59.6	1d4fD-3g1uA: 71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3glq	ADENOSYLHOMOCYSTEINA SE (Burkholderia pseudomallei)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	THR A  67 GLU A 199 THR A 200 HIS A 344 HIS A 394	RAB  A 602 (-4.5A) RAB  A 602 (-4.6A) NAD  A 601 ( 2.9A) RAB  A 602 ( 3.5A) NAD  A 601 ( 3.6A)	0.64A	1d4fD-3glqA: 56.9	1d4fD-3glqA: 56.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gri	DIHYDROOROTASE (Staphylococcus aureus)	PF01979 (Amidohydro_1)	4	GLU A 253 THR A 255 HIS A 258 HIS A  60	None None None ZN  A 500 (-3.7A)	1.40A	1d4fD-3griA: undetectable	1d4fD-3griA: 22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3h9u	ADENOSYLHOMOCYSTEINA SE (Trypanosoma brucei)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	THR A  57 GLU A 155 THR A 156 HIS A 300 HIS A 352	ADN  A 439 (-4.7A) None NAD  A 438 (-3.8A) None ADN  A 439 ( 3.3A)	0.66A	1d4fD-3h9uA: 61.5	1d4fD-3h9uA: 71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3iuu	PUTATIVE METALLOPEPTIDASE (Chelativorans sp. BNC1)	PF07171 (MlrC_C) PF07364 (DUF1485)	4	THR A 453 GLU A 202 THR A 160 HIS A 140	None None None ZN  A 495 ( 3.1A)	1.46A	1d4fD-3iuuA: 3.6	1d4fD-3iuuA: 22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3n58	ADENOSYLHOMOCYSTEINA SE (Brucella abortus)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	THR A  60 GLU A 192 THR A 193 HIS A 337 HIS A 387	ADN  A 500 (-4.6A) ADN  A 500 (-3.6A) NAD  A 550 ( 3.0A) ADN  A 500 ( 3.6A) ADN  A 500 (-3.4A)	0.58A	1d4fD-3n58A: 56.7	1d4fD-3n58A: 58.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3na0	CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL (Homo sapiens)	PF00067 (p450)	4	THR A 438 GLU A 383 THR A 384 HIS A 338	None	1.36A	1d4fD-3na0A: undetectable	1d4fD-3na0A: 20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3one	ADENOSYLHOMOCYSTEINA SE (Lupinus luteus)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	THR A  67 GLU A 205 THR A 206 HIS A 350 HIS A 404	ADE  A 506 (-4.5A) None NAD  A 501 (-2.8A) None ADE  A 506 (-3.4A)	0.58A	1d4fD-3oneA: 53.7	1d4fD-3oneA: 57.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ubu	AGGLUCETIN SUBUNIT ALPHA-1 AGGLUCETIN SUBUNIT BETA-2 (Deinagkistrodon acutus)	PF00059 (Lectin_C)	4	GLU A  82 THR A  84 HIS B  40 HIS B  45	None None None GOL  B 128 (-4.0A)	1.38A	1d4fD-3ubuA: undetectable	1d4fD-3ubuA: 15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3w6m	458AA LONG HYPOTHETICAL ENDO-1,4-BETA-GLUCAN ASE (Pyrococcus horikoshii)	PF00150 (Cellulase)	4	THR A 160 GLU A 163 HIS A 203 HIS A 155	None	1.34A	1d4fD-3w6mA: undetectable	1d4fD-3w6mA: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4b90	DIHYDROPYRIMIDINASE- RELATED PROTEIN 5 (Homo sapiens)	PF01979 (Amidohydro_1)	4	GLU A 270 THR A 272 HIS A 275 HIS A  68	None	1.31A	1d4fD-4b90A: undetectable	1d4fD-4b90A: 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4b92	DIHYDROPYRIMIDINASE- RELATED PROTEIN 5 (Homo sapiens)	PF01979 (Amidohydro_1)	4	GLU A 270 THR A 272 HIS A 275 HIS A  68	None	1.32A	1d4fD-4b92A: undetectable	1d4fD-4b92A: 20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4dx8	KREV INTERACTION TRAPPED PROTEIN 1 (Homo sapiens)	PF16705 (NUDIX_5)	4	THR H 153 GLU H  55 THR H  56 HIS H  38	None	1.21A	1d4fD-4dx8H: undetectable	1d4fD-4dx8H: 17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hr3	PUTATIVE ACYL-COA DEHYDROGENASE (Mycobacteroides abscessus)	PF00441 (Acyl-CoA_dh_1) PF02770 (Acyl-CoA_dh_M) PF02771 (Acyl-CoA_dh_N)	4	THR A 102 THR A 178 HIS A 234 HIS A 271	None FAD  A 501 (-3.9A) FAD  A 501 (-4.2A) None	1.45A	1d4fD-4hr3A: undetectable	1d4fD-4hr3A: 22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4iv5	ASPARTATE CARBAMOYLTRANSFERASE , PUTATIVE (Trypanosoma cruzi)	PF00185 (OTCace) PF02729 (OTCace_N)	4	THR A 151 THR A 175 HIS A 141 HIS A 287	None None UNX  A 402 ( 4.2A) None	1.37A	1d4fD-4iv5A: 4.5	1d4fD-4iv5A: 21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4lgl	GLYCINE DEHYDROGENASE [DECARBOXYLATING] (Synechocystis sp. PCC 6803)	PF02347 (GDC-P)	4	THR A 867 GLU A 879 THR A 881 HIS A 732	CME  A 974 ( 3.9A) None None None	1.30A	1d4fD-4lglA: 4.1	1d4fD-4lglA: 19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lvc	S-ADENOSYL-L-HOMOCYS TEINE HYDROLASE (SAHASE) (Bradyrhizobium elkanii)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	THR A  63 GLU A 197 THR A 198 HIS A 342 HIS A 392	ADN  A 501 (-4.5A) ADN  A 501 (-3.6A) NAD  A 503 ( 2.9A) ADN  A 501 ( 3.7A) ADN  A 501 (-3.5A)	0.60A	1d4fD-4lvcA: 56.5	1d4fD-4lvcA: 58.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4mkv	RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN (Pisum sativum)	PF00016 (RuBisCO_large) PF02788 (RuBisCO_large_N)	4	THR A 271 GLU A 204 HIS A 292 HIS A 298	None RUB  A 501 (-3.2A) None RUB  A 501 ( 4.9A)	1.47A	1d4fD-4mkvA: undetectable	1d4fD-4mkvA: 20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4nx8	PROTEIN-TYROSINE PHOSPHATASE 2 (Bdellovibrio bacteriovorus)	PF14566 (PTPlike_phytase)	4	THR A 174 GLU A 103 THR A 114 HIS A 205	None	1.46A	1d4fD-4nx8A: undetectable	1d4fD-4nx8A: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4q3l	MGS-M2 (unidentified)	PF00561 (Abhydrolase_1)	4	THR A 194 THR A 224 HIS A 249 HIS A 200	None	1.34A	1d4fD-4q3lA: 5.0	1d4fD-4q3lA: 23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rml	LATROPHILIN-3 (Mus musculus)	PF02191 (OLF)	4	THR A 247 GLU A 291 THR A 293 HIS A 272	None	1.43A	1d4fD-4rmlA: undetectable	1d4fD-4rmlA: 20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4whb	PHENYLUREA HYDROLASE B (Mycolicibacterium brisbanense)	no annotation	4	THR E 230 THR E 142 HIS E 114 HIS E 180	None	1.35A	1d4fD-4whbE: undetectable	1d4fD-4whbE: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wz9	AGAP004809-PA (Anopheles gambiae)	PF01433 (Peptidase_M1) PF11838 (ERAP1_C)	4	THR A 249 GLU A 244 THR A 245 HIS A  83	None	1.50A	1d4fD-4wz9A: undetectable	1d4fD-4wz9A: 20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xd9	RIBOSOME BIOGENESIS PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04790) (Aspergillus nidulans)	PF04427 (Brix)	4	THR A 197 GLU A 195 HIS A 205 HIS A 161	None	1.19A	1d4fD-4xd9A: undetectable	1d4fD-4xd9A: 23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xkj	D-LACTATE DEHYDROGENASE (Sporolactobacillus inulinus)	PF00389 (2-Hacid_dh) PF02826 (2-Hacid_dh_C)	4	THR A 211 THR A 259 HIS A 295 HIS A 204	NAD  A 401 (-4.5A) None NAD  A 401 (-3.7A) None	1.46A	1d4fD-4xkjA: 4.4	1d4fD-4xkjA: 23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xy3	ESX-1 SECRETION-ASSOCIATED PROTEIN ESPB (Mycobacterium tuberculosis)	no annotation	4	THR A  40 GLU A  38 THR A 142 HIS A 216	None	1.46A	1d4fD-4xy3A: undetectable	1d4fD-4xy3A: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5by8	RPF2 (Aspergillus nidulans)	PF04427 (Brix)	4	THR A 197 GLU A 195 HIS A 205 HIS A 161	None	1.29A	1d4fD-5by8A: undetectable	1d4fD-5by8A: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cmn	LATROPHILIN-3 (Homo sapiens)	PF02191 (OLF)	4	THR E 179 GLU E 223 THR E 225 HIS E 204	None	1.48A	1d4fD-5cmnE: undetectable	1d4fD-5cmnE: 17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5epa	SNOK (Streptomyces nogalater)	PF05721 (PhyH)	4	THR A 135 GLU A 124 THR A 125 HIS A 210	None None None FE  A 300 ( 3.3A)	1.39A	1d4fD-5epaA: undetectable	1d4fD-5epaA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5k8d	COAGULATION FACTOR VIII (Homo sapiens)	PF00394 (Cu-oxidase) PF07732 (Cu-oxidase_3)	4	GLU A 187 THR A 191 HIS A 193 HIS A 256	None	1.27A	1d4fD-5k8dA: undetectable	1d4fD-5k8dA: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ngk	GLUCOSYLCERAMIDASE (Bacteroides thetaiotaomicron)	PF02055 (Glyco_hydro_30) PF17189 (Glyco_hydro_30C)	4	THR A  89 GLU A 339 THR A 340 HIS A 415	None	1.28A	1d4fD-5ngkA: undetectable	1d4fD-5ngkA: 21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5utu	ADENOSYLHOMOCYSTEINA SE (Cryptosporidium parvum)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	4	THR A  58 GLU A 211 THR A 212 HIS A 410	SAH  A 502 (-4.2A) SAH  A 502 (-3.8A) NAD  A 501 ( 4.1A) SAH  A 502 ( 3.5A)	0.78A	1d4fD-5utuA: 51.5	1d4fD-5utuA: 48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5v96	S-ADENOSYL-L-HOMOCYS TEINE HYDROLASE (Naegleria fowleri)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	4	THR A  64 GLU A 197 THR A 198 HIS A 395	ADN  A 502 (-4.4A) ADN  A 502 (-3.5A) NAD  A 501 ( 2.9A) ADN  A 502 ( 3.4A)	0.65A	1d4fD-5v96A: 55.8	1d4fD-5v96A: 57.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5wt4	CYSTEINE DESULFURASE ISCS (Helicobacter pylori)	no annotation	4	GLU A  43 THR A  44 HIS A  45 HIS A  38	None	1.42A	1d4fD-5wt4A: 2.3	1d4fD-5wt4A: 11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ams	BETA SLIDING CLAMP (Pseudomonas aeruginosa)	no annotation	4	THR A 232 GLU A  52 THR A 118 HIS A 223	None None None PO4  A 401 (-4.4A)	1.22A	1d4fD-6amsA: undetectable	1d4fD-6amsA: 22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6aph	ADENOSYLHOMOCYSTEINA SE (Elizabethkingia anophelis)	PF00670 (AdoHcyase_NAD) PF05221 (AdoHcyase)	5	THR A  63 GLU A 161 THR A 162 HIS A 306 HIS A 358	ADN  A 501 (-4.5A) ADN  A 501 (-2.5A) NAD  A 500 ( 2.9A) ADN  A 501 ( 3.7A) ADN  A 501 ( 3.5A)	0.83A	1d4fD-6aphA: 61.5	1d4fD-6aphA: 66.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6f3m	- (-)	no annotation	5	THR B  66 GLU B 164 THR B 165 HIS B 323 HIS B 382	ADN  B 502 (-4.6A) ADN  B 502 (-3.6A) NAD  B 501 ( 2.8A) ZN  B 505 (-3.2A) ADN  B 502 (-3.4A)	0.60A	1d4fD-6f3mB: 55.2	1d4fD-6f3mB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6gbn	- (-)	no annotation	5	THR A  61 GLU A 159 THR A 160 HIS A 304 HIS A 356	ADN  A 501 (-4.6A) ADN  A 501 (-3.9A) NAD  A 502 ( 2.8A) ADN  A 501 ( 3.6A) ADN  A 501 (-3.4A)	0.61A	1d4fD-6gbnA: 61.6	1d4fD-6gbnA: undetectable