SIMILAR PATTERNS OF AMINO ACIDS FOR 1D4F_C_ADNC603_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfr RESTRICTION
ENDONUCLEASE

(Citrobacter
freundii) 		PF07832
(Bse634I) 		4 THR A 234
GLU A  34
THR A  33
LEU A  73
 None
 1.38A 1d4fC-1cfrA:
undetectable		 1d4fC-1cfrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 THR A 578
GLU A 460
THR A 457
LEU A 471
 None
 1.38A 1d4fC-1d8cA:
undetectable		 1d4fC-1d8cA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta) 		PF02763
(Diphtheria_C) 		4 THR A  23
GLU A 168
THR A 169
LEU A 163
 APU  A 200 ( 4.6A)
None
None
None
 1.29A 1d4fC-1dtpA:
undetectable		 1d4fC-1dtpA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 THR A 399
THR A 308
HIS A 300
LEU A 222
 None
 1.06A 1d4fC-1exxA:
undetectable		 1d4fC-1exxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fo0 PROTEIN (BM3.3 T
CELL RECEPTOR
ALPHA-CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 THR A  38
THR A  80
HIS A  61
LEU A  46
 None
 1.35A 1d4fC-1fo0A:
undetectable		 1d4fC-1fo0A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 4 THR A 113
GLU A  78
THR A  77
LEU A  71
 None
 1.23A 1d4fC-1hz4A:
undetectable		 1d4fC-1hz4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5a CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c) 		4 GLU A 390
THR A 389
HIS A 438
LEU A 539
 None
 0.99A 1d4fC-1i5aA:
undetectable		 1d4fC-1i5aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 THR A 218
THR A 117
HIS A  89
LEU A 239
 None
5CA  A 512 (-3.5A)
None
None
 1.34A 1d4fC-1nj1A:
undetectable		 1d4fC-1nj1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 THR A 111
GLU A 157
HIS A  20
LEU A 160
 None
 1.39A 1d4fC-1t1eA:
3.7		 1d4fC-1t1eA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		4 THR A 120
GLU A 125
THR A 100
HIS A  67
 None
 1.34A 1d4fC-1tf1A:
undetectable		 1d4fC-1tf1A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE

(Mycobacterium
tuberculosis) 		PF01451
(LMWPc) 		4 THR A  41
GLU A  79
THR A  78
LEU A  86
 None
 1.39A 1d4fC-1u2qA:
4.6		 1d4fC-1u2qA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdi HYPOTHETICAL PROTEIN
TT0907

(Thermus
thermophilus) 		PF02547
(Queuosine_synth) 		4 THR A 215
GLU A 280
THR A 281
LEU A 209
 None
 1.26A 1d4fC-1wdiA:
undetectable		 1d4fC-1wdiA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 GLU B 420
THR A   4
HIS A   6
LEU B 427
 None
 1.36A 1d4fC-1wytB:
2.4		 1d4fC-1wytB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLU A  22
THR A  18
HIS A  13
LEU A  48
 None
 1.20A 1d4fC-1yq9A:
4.8		 1d4fC-1yq9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1znp HYPOTHETICAL PROTEIN
ATU3615

(Agrobacterium
fabrum) 		PF06172
(Cupin_5) 		4 GLU A  63
THR A 123
HIS A  66
LEU A  89
 None
 1.36A 1d4fC-1znpA:
undetectable		 1d4fC-1znpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b30 PVIVAX HYPOTHETICAL
PROTEIN

(Plasmodium
vivax) 		PF08282
(Hydrolase_3) 		4 GLU A 217
THR A 211
HIS A 215
LEU A 156
 None
 1.37A 1d4fC-2b30A:
3.3		 1d4fC-2b30A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 THR A 202
THR A 580
HIS A 581
LEU A 514
 None
None
CU  A 640 (-3.5A)
None
 1.17A 1d4fC-2eidA:
undetectable		 1d4fC-2eidA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 GLU A 268
THR A 272
HIS A 229
LEU A 192
 None
ZN  A 500 ( 4.8A)
ZN  A 500 (-3.1A)
None
 1.11A 1d4fC-2fpqA:
undetectable		 1d4fC-2fpqA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvk HEME PEROXIDASE

(Bacteroides
thetaiotaomicron) 		PF04261
(Dyp_perox) 		4 THR A 235
THR A 260
HIS A 194
LEU A 292
 None
ACY  A 327 ( 3.9A)
ACY  A 327 (-4.4A)
None
 1.16A 1d4fC-2gvkA:
undetectable		 1d4fC-2gvkA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1r DIMETHYLADENOSINE
TRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00398
(RrnaAD) 		4 THR A  32
GLU A  27
THR A  90
LEU A  10
 None
 1.38A 1d4fC-2h1rA:
3.6		 1d4fC-2h1rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 THR A  60
GLU A  88
THR A  89
LEU A 573
 None
 1.15A 1d4fC-2h4tA:
undetectable		 1d4fC-2h4tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 THR A 230
GLU A 521
THR A 517
LEU A  50
 None
None
None
FAD  A1001 (-3.8A)
 1.21A 1d4fC-2h88A:
3.7		 1d4fC-2h88A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		4 THR A 249
THR A 295
HIS A   8
LEU A  35
 None
 1.37A 1d4fC-2i5gA:
undetectable		 1d4fC-2i5gA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		4 THR A 148
GLU A 156
HIS A 260
LEU A 207
 None
 1.17A 1d4fC-2j0wA:
undetectable		 1d4fC-2j0wA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7h HYPOTHETICAL PROTEIN

(Pectobacterium
atrosepticum) 		PF13489
(Methyltransf_23) 		4 THR A 109
THR A  37
HIS A  62
LEU A  45
 TRS  A 251 (-4.1A)
None
None
None
 0.99A 1d4fC-2p7hA:
2.4		 1d4fC-2p7hA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q07 UNCHARACTERIZED
PROTEIN AF0587

(Archaeoglobus
fulgidus) 		PF01472
(PUA) 		4 THR A 350
THR A 267
HIS A 278
LEU A 377
 None
 1.33A 1d4fC-2q07A:
undetectable		 1d4fC-2q07A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm8 GTPASE/ATPASE

(Methylobacterium
extorquens) 		PF03308
(ArgK) 		4 THR A  71
GLU A 154
THR A 155
LEU A 173
 None
 1.16A 1d4fC-2qm8A:
3.6		 1d4fC-2qm8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 THR A 285
THR A  36
HIS A   1
LEU A 314
 None
 1.36A 1d4fC-2qpsA:
undetectable		 1d4fC-2qpsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		4 THR A 138
GLU A   9
THR A  87
LEU A  52
 None
 1.38A 1d4fC-2varA:
2.4		 1d4fC-2varA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 THR A 736
GLU A 744
HIS A 630
LEU A 623
 None
 1.29A 1d4fC-2zzgA:
undetectable		 1d4fC-2zzgA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 THR A   4
THR A 353
HIS A   9
LEU A  36
 None
 1.35A 1d4fC-3acpA:
undetectable		 1d4fC-3acpA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLU B  28
THR B  24
HIS B  19
LEU B  54
 None
 1.25A 1d4fC-3ayxB:
4.1		 1d4fC-3ayxB:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  74
GLU A 218
THR A 219
HIS A 363
LEU A 410
 ADN  A 500 (-4.5A)
ADN  A 500 (-2.6A)
NAD  A 550 ( 2.8A)
ADN  A 500 ( 3.7A)
ADN  A 500 ( 4.8A)
 0.73A 1d4fC-3ce6A:
54.8		 1d4fC-3ce6A:
54.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exq NUDIX FAMILY
HYDROLASE

(Lactobacillus
brevis) 		PF00293
(NUDIX) 		4 THR A  64
GLU A  59
THR A  13
LEU A  68
 None
SO4  A 201 ( 4.1A)
None
None
 1.32A 1d4fC-3exqA:
undetectable		 1d4fC-3exqA:
13.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  57
GLU A 155
THR A 156
HIS A 300
LEU A 346
 ADN  A 438 (-4.6A)
ADN  A 438 (-3.8A)
NAD  A 439 ( 3.0A)
ADN  A 438 ( 4.0A)
ADN  A 438 ( 4.8A)
 0.64A 1d4fC-3g1uA:
59.7		 1d4fC-3g1uA:
71.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 THR A 375
GLU A 459
HIS A 460
LEU A 425
 None
 0.88A 1d4fC-3gg4A:
undetectable		 1d4fC-3gg4A:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  67
GLU A 199
THR A 200
HIS A 344
LEU A 388
 RAB  A 602 (-4.5A)
RAB  A 602 (-4.6A)
NAD  A 601 ( 2.9A)
RAB  A 602 ( 3.5A)
RAB  A 602 ( 4.7A)
 0.67A 1d4fC-3glqA:
57.0		 1d4fC-3glqA:
56.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  57
GLU A 155
THR A 156
HIS A 300
LEU A 346
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
None
ADN  A 439 ( 4.7A)
 0.66A 1d4fC-3h9uA:
61.4		 1d4fC-3h9uA:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 THR A 673
GLU A 268
THR A 269
LEU A 464
 None
 1.30A 1d4fC-3j04A:
undetectable		 1d4fC-3j04A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		4 THR A 234
GLU A 385
THR A 386
HIS A 342
 None
NAP  A 482 (-3.5A)
None
None
 1.21A 1d4fC-3jz4A:
4.0		 1d4fC-3jz4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdr HK97 FAMILY PHAGE
PORTAL PROTEIN

(Corynebacterium
diphtheriae) 		PF04860
(Phage_portal) 		4 THR A  73
GLU A 299
THR A 295
LEU A 331
 None
 1.34A 1d4fC-3kdrA:
undetectable		 1d4fC-3kdrA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 THR A 294
GLU A 296
HIS A 392
LEU A 428
 None
MG  A 597 (-3.9A)
BTB  A 605 (-4.1A)
None
 1.31A 1d4fC-3m07A:
undetectable		 1d4fC-3m07A:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  60
GLU A 192
THR A 193
HIS A 337
LEU A 381
 ADN  A 500 (-4.6A)
ADN  A 500 (-3.6A)
NAD  A 550 ( 3.0A)
ADN  A 500 ( 3.6A)
ADN  A 500 ( 4.8A)
 0.58A 1d4fC-3n58A:
56.9		 1d4fC-3n58A:
58.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  67
GLU A 205
THR A 206
HIS A 350
LEU A 398
 ADE  A 506 (-4.5A)
None
NAD  A 501 (-2.8A)
None
ADE  A 506 ( 4.7A)
 0.58A 1d4fC-3oneA:
53.6		 1d4fC-3oneA:
57.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		4 THR A 101
THR A 138
HIS A 163
LEU A 176
 None
 1.28A 1d4fC-3rhdA:
4.4		 1d4fC-3rhdA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A   7
THR A   8
HIS A  44
LEU A  52
 None
 1.30A 1d4fC-3t8qA:
undetectable		 1d4fC-3t8qA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  29
THR A  30
HIS A  66
LEU A  74
 None
 1.17A 1d4fC-3t9pA:
undetectable		 1d4fC-3t9pA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A   7
THR A   8
HIS A  44
LEU A  52
 None
 1.15A 1d4fC-3tcsA:
undetectable		 1d4fC-3tcsA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A   7
THR A   8
HIS A  44
LEU A  52
 None
 1.12A 1d4fC-3u4fA:
undetectable		 1d4fC-3u4fA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		4 THR A 231
GLU A 281
THR A 280
LEU A 284
 None
 1.14A 1d4fC-3u4yA:
undetectable		 1d4fC-3u4yA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 GLU A 184
THR A 186
HIS A 213
LEU A 367
 None
 1.24A 1d4fC-3w4rA:
undetectable		 1d4fC-3w4rA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 GLU A 184
THR A 186
HIS A 213
LEU A 367
 None
 1.28A 1d4fC-3wl1A:
undetectable		 1d4fC-3wl1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 GLU A 468
THR A 469
HIS A 471
LEU A 723
 None
 1.26A 1d4fC-3zhrA:
2.9		 1d4fC-3zhrA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak1 BT_4661

(Bacteroides
thetaiotaomicron) 		PF16319
(DUF4958) 		4 GLU A 240
THR A 249
HIS A 294
LEU A 325
 None
 1.24A 1d4fC-4ak1A:
undetectable		 1d4fC-4ak1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 4 THR A  83
THR A 109
HIS A   8
LEU A 254
 None
 1.03A 1d4fC-4cmrA:
undetectable		 1d4fC-4cmrA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dve BIOTIN TRANSPORTER
BIOY

(Lactococcus
lactis) 		PF02632
(BioY) 		4 THR A 170
GLU A 121
THR A 113
LEU A  51
 None
 1.27A 1d4fC-4dveA:
undetectable		 1d4fC-4dveA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e10 PROTELOMERASE

(Agrobacterium
fabrum) 		PF16684
(Telomere_res) 		4 GLU A 371
THR A 407
HIS A 367
LEU A 392
 None
PTR  A 405 ( 4.1A)
PTR  A 405 ( 3.5A)
PTR  A 405 ( 4.9A)
 1.38A 1d4fC-4e10A:
undetectable		 1d4fC-4e10A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		4 THR A 196
GLU A 226
THR A 223
LEU A  91
 None
None
None
NOS  A 501 ( 4.8A)
 1.15A 1d4fC-4f0sA:
undetectable		 1d4fC-4f0sA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fah GENTISATE
1,2-DIOXYGENASE

(Pseudaminobacter
salicylatoxidans) 		PF07883
(Cupin_2) 		4 THR A 301
THR A 292
HIS A 261
LEU A 345
 None
 1.18A 1d4fC-4fahA:
undetectable		 1d4fC-4fahA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 THR A 774
GLU A 734
THR A 695
LEU A 713
 None
 1.39A 1d4fC-4fddA:
undetectable		 1d4fC-4fddA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd3 HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		no annotation 4 GLU S  22
THR S  18
HIS S  13
LEU S  48
 None
 1.35A 1d4fC-4gd3S:
3.9		 1d4fC-4gd3S:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		4 THR A 357
GLU A 317
THR A 318
LEU A 249
 ATP  A 502 (-4.4A)
None
None
None
 1.39A 1d4fC-4gniA:
undetectable		 1d4fC-4gniA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		4 THR A 220
THR A 138
HIS A 386
LEU A 227
 None
 1.40A 1d4fC-4hh1A:
3.8		 1d4fC-4hh1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkj TRANSCOBALAMIN-1

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 THR A 221
GLU A 252
THR A 251
LEU A 271
 None
 1.30A 1d4fC-4kkjA:
undetectable		 1d4fC-4kkjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE

(Rhodopseudomonas
palustris) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 THR A 346
GLU A 342
THR A 339
LEU A 359
 None
 1.22A 1d4fC-4ksaA:
undetectable		 1d4fC-4ksaA:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  63
GLU A 197
THR A 198
HIS A 342
LEU A 386
 ADN  A 501 (-4.5A)
ADN  A 501 (-3.6A)
NAD  A 503 ( 2.9A)
ADN  A 501 ( 3.7A)
ADN  A 501 ( 4.7A)
 0.56A 1d4fC-4lvcA:
56.5		 1d4fC-4lvcA:
58.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		4 THR A 318
GLU A  13
THR A  12
LEU A  22
 None
 1.39A 1d4fC-4lz6A:
undetectable		 1d4fC-4lz6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		4 THR A 222
GLU A 245
THR A 246
LEU A 140
 None
None
None
GOL  A 404 (-4.2A)
 1.22A 1d4fC-4mioA:
4.1		 1d4fC-4mioA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 CALCIUM-BINDING
PROTEIN 39

(Homo sapiens) 		PF08569
(Mo25) 		4 THR A 122
GLU A 118
THR A 114
LEU A 156
 None
 1.26A 1d4fC-4o27A:
undetectable		 1d4fC-4o27A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 THR A 542
GLU A 550
THR A 563
LEU A 557
 None
 1.23A 1d4fC-4oonA:
undetectable		 1d4fC-4oonA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		4 THR A 233
GLU A 212
THR A 174
LEU A 187
 None
 0.95A 1d4fC-4p47A:
undetectable		 1d4fC-4p47A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz0 NUCLEOLAR PROTEIN 3

(Homo sapiens) 		PF00619
(CARD) 		4 THR A  22
GLU A  15
THR A  11
LEU A  62
 None
 1.29A 1d4fC-4uz0A:
undetectable		 1d4fC-4uz0A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4m HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLU S  22
THR S  18
HIS S  13
LEU S  48
 None
 1.29A 1d4fC-5a4mS:
3.5		 1d4fC-5a4mS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 THR A 107
GLU A 589
THR A 592
LEU A 690
 None
 1.15A 1d4fC-5cj5A:
undetectable		 1d4fC-5cj5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 4 THR B 553
GLU B 558
THR B 590
LEU B  30
 None
 1.22A 1d4fC-5cyrB:
undetectable		 1d4fC-5cyrB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 THR A 187
GLU A 185
THR A 253
LEU A 261
 None
 1.37A 1d4fC-5d39A:
undetectable		 1d4fC-5d39A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A 222
THR A 280
HIS A 145
LEU A 169
 THR  A 222 ( 0.8A)
THR  A 280 ( 0.8A)
HIS  A 145 ( 1.0A)
LEU  A 169 ( 0.6A)
 0.99A 1d4fC-5d7aA:
undetectable		 1d4fC-5d7aA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 4 THR I 342
THR I 281
HIS I 267
LEU I 330
 None
 1.02A 1d4fC-5furI:
undetectable		 1d4fC-5furI:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		4 THR A 356
THR A 290
HIS A 206
LEU A 225
 None
 1.37A 1d4fC-5gnxA:
undetectable		 1d4fC-5gnxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 THR A 308
GLU A 299
THR A 298
LEU A 269
 None
EDO  A 505 ( 4.2A)
None
None
 1.22A 1d4fC-5h80A:
5.6		 1d4fC-5h80A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 THR A 308
GLU A 299
THR A 298
LEU A 324
 None
EDO  A 505 ( 4.2A)
None
None
 1.39A 1d4fC-5h80A:
5.6		 1d4fC-5h80A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 THR A 383
THR A 308
HIS A 217
LEU A 240
 None
 1.24A 1d4fC-5jboA:
undetectable		 1d4fC-5jboA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 THR A 575
GLU A 582
THR A 371
LEU A  74
 None
 0.78A 1d4fC-5jouA:
undetectable		 1d4fC-5jouA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 THR A 397
THR A 306
HIS A 298
LEU A 220
 None
 0.96A 1d4fC-5k13A:
undetectable		 1d4fC-5k13A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb9 PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		4 THR A 357
GLU A 317
THR A 318
LEU A 249
 None
 1.39A 1d4fC-5mb9A:
undetectable		 1d4fC-5mb9A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdj HOXK
UPTAKE HYDROGENASE
SMALL SUBUNIT

(Cupriavidus
necator) 		no annotation 4 GLU S  22
THR S  18
HIS S  13
LEU S  48
 None
 1.21A 1d4fC-5mdjS:
3.3		 1d4fC-5mdjS:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 THR A  89
GLU A 339
THR A 340
HIS A 415
 None
 1.27A 1d4fC-5ngkA:
undetectable		 1d4fC-5ngkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr1 FTSZ-BINDING PROTEIN
FZLA

(Caulobacter
vibrioides) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 GLU A  81
THR A  80
HIS A  76
LEU A  56
 None
 1.36A 1d4fC-5nr1A:
undetectable		 1d4fC-5nr1A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 THR B  31
GLU B  27
THR B 480
LEU B  52
 None
 1.39A 1d4fC-5of4B:
undetectable		 1d4fC-5of4B:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 4 THR B 390
THR B 299
HIS B 291
LEU B 213
 None
 1.16A 1d4fC-5uanB:
undetectable		 1d4fC-5uanB:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  58
GLU A 211
THR A 212
LEU A 404
 SAH  A 502 (-4.2A)
SAH  A 502 (-3.8A)
NAD  A 501 ( 4.1A)
SAH  A 502 ( 4.7A)
 0.66A 1d4fC-5utuA:
51.6		 1d4fC-5utuA:
48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  64
GLU A 197
THR A 198
LEU A 389
 ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 ( 4.7A)
 0.54A 1d4fC-5v96A:
29.1		 1d4fC-5v96A:
57.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 THR A 648
THR A 276
HIS A 308
LEU A 625
 None
 1.35A 1d4fC-5x9wA:
undetectable		 1d4fC-5x9wA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 4 THR A 355
THR A 291
HIS A 205
LEU A 226
 None
 1.38A 1d4fC-5xgzA:
undetectable		 1d4fC-5xgzA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 GLU A 823
THR A 821
HIS A 908
LEU A 747
 None
 1.40A 1d4fC-5ywzA:
undetectable		 1d4fC-5ywzA:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  63
GLU A 161
THR A 162
HIS A 306
LEU A 352
 ADN  A 501 (-4.5A)
ADN  A 501 (-2.5A)
NAD  A 500 ( 2.9A)
ADN  A 501 ( 3.7A)
ADN  A 501 ( 4.8A)
 0.75A 1d4fC-6aphA:
61.4		 1d4fC-6aphA:
66.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE

(Elizabethkingia
anophelis) 		no annotation 4 GLU A 307
THR A 306
HIS A 302
LEU A 315
 None
 1.12A 1d4fC-6bzcA:
2.4		 1d4fC-6bzcA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cer PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
ALPHA, SOMATIC FORM,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 THR A 237
GLU A  76
THR A  97
LEU A 164
 None
 1.11A 1d4fC-6cerA:
undetectable		 1d4fC-6cerA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 5 THR B  66
GLU B 164
THR B 165
HIS B 323
LEU B 376
 ADN  B 502 (-4.6A)
ADN  B 502 (-3.6A)
NAD  B 501 ( 2.8A)
ZN  B 505 (-3.2A)
ADN  B 502 ( 4.8A)
 0.58A 1d4fC-6f3mB:
55.2		 1d4fC-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 5 THR A  61
GLU A 159
THR A 160
HIS A 304
LEU A 350
 ADN  A 501 (-4.6A)
ADN  A 501 (-3.9A)
NAD  A 502 ( 2.8A)
ADN  A 501 ( 3.6A)
ADN  A 501 ( 4.7A)
 0.59A 1d4fC-6gbnA:
61.5		 1d4fC-6gbnA:
undetectable