SIMILAR PATTERNS OF AMINO ACIDS FOR 1D4F_A_ADNA601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ah9 INITIATION FACTOR 1

(Escherichia
coli) 		PF01176
(eIF-1a) 		4 THR A  53
GLU A  55
THR A  57
HIS A  34
 None
 1.38A 1d4fA-1ah9A:
undetectable		 1d4fA-1ah9A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		4 THR A 247
GLU A 254
HIS A 280
HIS A 252
 None
 1.37A 1d4fA-1c4xA:
5.5		 1d4fA-1c4xA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxi PHOSPHOMETHYLPYRIMID
INE KINASE

(Salmonella
enterica) 		PF08543
(Phos_pyr_kin) 		4 THR A 205
THR A 214
HIS A 261
HIS A 209
 None
None
None
SO4  A2005 (-4.3A)
 1.42A 1d4fA-1jxiA:
5.6		 1d4fA-1jxiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		4 THR A 106
GLU A 145
THR A 148
HIS A 350
 None
PLP  A 400 ( 4.7A)
None
None
 1.03A 1d4fA-1n8pA:
undetectable		 1d4fA-1n8pA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		4 THR A 687
GLU A 702
THR A 701
HIS A 705
 None
 1.14A 1d4fA-1qafA:
undetectable		 1d4fA-1qafA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		4 THR A 120
GLU A 125
THR A 100
HIS A  67
 None
 1.34A 1d4fA-1tf1A:
undetectable		 1d4fA-1tf1A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 THR B 403
GLU B 417
THR B 419
HIS B 272
 None
 1.32A 1d4fA-1wytB:
undetectable		 1d4fA-1wytB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		4 THR A 303
THR A 281
HIS A 283
HIS A 188
 None
 1.47A 1d4fA-2d7sA:
undetectable		 1d4fA-2d7sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsg HYPOTHETICAL PROTEIN
CGL3021

(Corynebacterium
glutamicum) 		PF11716
(MDMPI_N) 		4 THR A 137
THR A  73
HIS A  65
HIS A 122
 None
 1.36A 1d4fA-2nsgA:
undetectable		 1d4fA-2nsgA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		4 THR A 161
GLU A 181
THR A  75
HIS A  81
 None
None
None
FE  A1002 (-3.4A)
 1.40A 1d4fA-2p4zA:
undetectable		 1d4fA-2p4zA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 GLU A 256
THR A 258
HIS A 261
HIS A  57
 None
None
None
ZN  A1004 (-3.4A)
 1.40A 1d4fA-2z00A:
undetectable		 1d4fA-2z00A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02847
(MA3) 		4 THR B 169
GLU A 111
THR A 109
HIS B 215
 None
 1.34A 1d4fA-2zu6B:
undetectable		 1d4fA-2zu6B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 THR A 160
GLU A 163
HIS A 203
HIS A 155
 None
 1.28A 1d4fA-3axxA:
undetectable		 1d4fA-3axxA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bql ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		4 THR A1269
GLU A1307
THR A1308
HIS A1315
 None
 1.42A 1d4fA-3bqlA:
undetectable		 1d4fA-3bqlA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  74
GLU A 218
THR A 219
HIS A 363
HIS A 416
 ADN  A 500 (-4.5A)
ADN  A 500 (-2.6A)
NAD  A 550 ( 2.8A)
ADN  A 500 ( 3.7A)
ADN  A 500 ( 3.6A)
 0.76A 1d4fA-3ce6A:
54.9		 1d4fA-3ce6A:
54.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef8 PUTATIVE SCYALONE
DEHYDRATASE

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 THR A  58
THR A  69
HIS A  71
HIS A 138
 None
 1.49A 1d4fA-3ef8A:
undetectable		 1d4fA-3ef8A:
16.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  57
GLU A 155
THR A 156
HIS A 300
HIS A 352
 ADN  A 438 (-4.6A)
ADN  A 438 (-3.8A)
NAD  A 439 ( 3.0A)
ADN  A 438 ( 4.0A)
ADN  A 438 ( 3.6A)
 0.64A 1d4fA-3g1uA:
59.7		 1d4fA-3g1uA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  67
GLU A 199
THR A 200
HIS A 344
HIS A 394
 RAB  A 602 (-4.5A)
RAB  A 602 (-4.6A)
NAD  A 601 ( 2.9A)
RAB  A 602 ( 3.5A)
NAD  A 601 ( 3.6A)
 0.62A 1d4fA-3glqA:
57.2		 1d4fA-3glqA:
56.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  57
GLU A 155
THR A 156
HIS A 300
HIS A 352
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
None
ADN  A 439 ( 3.3A)
 0.69A 1d4fA-3h9uA:
61.4		 1d4fA-3h9uA:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE

(Chelativorans
sp. BNC1) 		PF07171
(MlrC_C)
PF07364
(DUF1485) 		4 THR A 453
GLU A 202
THR A 160
HIS A 140
 None
None
None
ZN  A 495 ( 3.1A)
 1.46A 1d4fA-3iuuA:
undetectable		 1d4fA-3iuuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		4 THR A 234
GLU A 385
THR A 386
HIS A 342
 None
NAP  A 482 (-3.5A)
None
None
 1.16A 1d4fA-3jz4A:
2.1		 1d4fA-3jz4A:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  60
GLU A 192
THR A 193
HIS A 337
HIS A 387
 ADN  A 500 (-4.6A)
ADN  A 500 (-3.6A)
NAD  A 550 ( 3.0A)
ADN  A 500 ( 3.6A)
ADN  A 500 (-3.4A)
 0.58A 1d4fA-3n58A:
56.9		 1d4fA-3n58A:
58.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  67
GLU A 205
THR A 206
HIS A 350
HIS A 404
 ADE  A 506 (-4.5A)
None
NAD  A 501 (-2.8A)
None
ADE  A 506 (-3.4A)
 0.58A 1d4fA-3oneA:
53.8		 1d4fA-3oneA:
57.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 THR A 420
GLU A 209
THR A 186
HIS A 413
 None
 1.47A 1d4fA-3szbA:
4.2		 1d4fA-3szbA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubu AGGLUCETIN SUBUNIT
ALPHA-1
AGGLUCETIN SUBUNIT
BETA-2

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		4 GLU A  82
THR A  84
HIS B  40
HIS B  45
 None
None
None
GOL  B 128 (-4.0A)
 1.39A 1d4fA-3ubuA:
undetectable		 1d4fA-3ubuA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 THR A 160
GLU A 163
HIS A 203
HIS A 155
 None
 1.24A 1d4fA-3w6mA:
undetectable		 1d4fA-3w6mA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 GLU A 270
THR A 272
HIS A 275
HIS A  68
 None
 1.39A 1d4fA-4b90A:
undetectable		 1d4fA-4b90A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 GLU A 270
THR A 272
HIS A 275
HIS A  68
 None
 1.41A 1d4fA-4b92A:
undetectable		 1d4fA-4b92A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by2 ANASTRAL SPINDLE 2,
SAS 4

(Drosophila
melanogaster) 		PF07202
(Tcp10_C) 		4 GLU A 136
THR A 142
HIS A 144
HIS A 125
 None
 1.49A 1d4fA-4by2A:
undetectable		 1d4fA-4by2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B

(Homo sapiens) 		PF02373
(JmjC) 		4 THR A1657
GLU A1592
THR A1589
HIS A1615
 None
 1.44A 1d4fA-4c8dA:
undetectable		 1d4fA-4c8dA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx8 KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF16705
(NUDIX_5) 		4 THR H 153
GLU H  55
THR H  56
HIS H  38
 None
 1.20A 1d4fA-4dx8H:
undetectable		 1d4fA-4dx8H:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2) 		4 GLU A 423
THR A  49
HIS A 422
HIS A 438
 None
 1.37A 1d4fA-4hppA:
undetectable		 1d4fA-4hppA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 THR A 867
GLU A 879
THR A 881
HIS A 732
 CME  A 974 ( 3.9A)
None
None
None
 1.31A 1d4fA-4lglA:
undetectable		 1d4fA-4lglA:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  63
GLU A 197
THR A 198
HIS A 342
HIS A 392
 ADN  A 501 (-4.5A)
ADN  A 501 (-3.6A)
NAD  A 503 ( 2.9A)
ADN  A 501 ( 3.7A)
ADN  A 501 (-3.5A)
 0.55A 1d4fA-4lvcA:
56.8		 1d4fA-4lvcA:
58.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2

(Bdellovibrio
bacteriovorus) 		PF14566
(PTPlike_phytase) 		4 THR A 174
GLU A 103
THR A 114
HIS A 205
 None
 1.40A 1d4fA-4nx8A:
undetectable		 1d4fA-4nx8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified) 		PF00561
(Abhydrolase_1) 		4 THR A 194
THR A 224
HIS A 249
HIS A 200
 None
 1.40A 1d4fA-4q3lA:
5.7		 1d4fA-4q3lA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 THR A 418
GLU A 207
THR A 184
HIS A 411
 None
 1.48A 1d4fA-4qgkA:
3.9		 1d4fA-4qgkA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 4 THR E 230
THR E 142
HIS E 114
HIS E 180
 None
 1.41A 1d4fA-4whbE:
undetectable		 1d4fA-4whbE:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)

(Aspergillus
nidulans) 		PF04427
(Brix) 		4 THR A 197
GLU A 195
HIS A 205
HIS A 161
 None
 1.21A 1d4fA-4xd9A:
undetectable		 1d4fA-4xd9A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 4 THR A  40
GLU A  38
THR A 142
HIS A 216
 None
 1.43A 1d4fA-4xy3A:
undetectable		 1d4fA-4xy3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 THR A1066
THR A1044
HIS A 579
HIS A1062
 None
 1.03A 1d4fA-4yswA:
undetectable		 1d4fA-4yswA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by8 RPF2

(Aspergillus
nidulans) 		PF04427
(Brix) 		4 THR A 197
GLU A 195
HIS A 205
HIS A 161
 None
 1.28A 1d4fA-5by8A:
undetectable		 1d4fA-5by8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgg UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 THR A 281
GLU A 299
THR A 300
HIS A 261
 None
 1.07A 1d4fA-5dggA:
undetectable		 1d4fA-5dggA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 THR A 151
GLU A 212
HIS A  77
HIS A 207
 None
None
NAP  A 401 (-3.2A)
None
 1.48A 1d4fA-5eioA:
3.6		 1d4fA-5eioA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 GLU A 187
THR A 191
HIS A 193
HIS A 256
 None
 1.40A 1d4fA-5k8dA:
undetectable		 1d4fA-5k8dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 THR A  97
GLU A  84
THR A  86
HIS A 189
 None
ARG  A 403 (-3.5A)
ARG  A 403 (-3.4A)
FE  A 401 (-3.3A)
 1.44A 1d4fA-5lunA:
undetectable		 1d4fA-5lunA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 THR A  89
GLU A 339
THR A 340
HIS A 415
 None
 1.31A 1d4fA-5ngkA:
undetectable		 1d4fA-5ngkA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  58
GLU A 211
THR A 212
HIS A 410
 SAH  A 502 (-4.2A)
SAH  A 502 (-3.8A)
NAD  A 501 ( 4.1A)
SAH  A 502 ( 3.5A)
 0.72A 1d4fA-5utuA:
51.6		 1d4fA-5utuA:
48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A  64
GLU A 197
THR A 198
HIS A 395
 ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 ( 3.4A)
 0.55A 1d4fA-5v96A:
56.0		 1d4fA-5v96A:
57.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 4 GLU A  43
THR A  44
HIS A  45
HIS A  38
 None
 1.37A 1d4fA-5wt4A:
2.3		 1d4fA-5wt4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 4 THR A 232
GLU A  52
THR A 118
HIS A 223
 None
None
None
PO4  A 401 (-4.4A)
 1.16A 1d4fA-6amsA:
undetectable		 1d4fA-6amsA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  63
GLU A 161
THR A 162
HIS A 306
HIS A 358
 ADN  A 501 (-4.5A)
ADN  A 501 (-2.5A)
NAD  A 500 ( 2.9A)
ADN  A 501 ( 3.7A)
ADN  A 501 ( 3.5A)
 0.79A 1d4fA-6aphA:
61.5		 1d4fA-6aphA:
66.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 5 THR B  66
GLU B 164
THR B 165
HIS B 323
HIS B 382
 ADN  B 502 (-4.6A)
ADN  B 502 (-3.6A)
NAD  B 501 ( 2.8A)
ZN  B 505 (-3.2A)
ADN  B 502 (-3.4A)
 0.54A 1d4fA-6f3mB:
55.2		 1d4fA-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 5 THR A  61
GLU A 159
THR A 160
HIS A 304
HIS A 356
 ADN  A 501 (-4.6A)
ADN  A 501 (-3.9A)
NAD  A 502 ( 2.8A)
ADN  A 501 ( 3.6A)
ADN  A 501 (-3.4A)
 0.56A 1d4fA-6gbnA:
61.6		 1d4fA-6gbnA:
undetectable