SIMILAR PATTERNS OF AMINO ACIDS FOR 1D0V_A_NIOA991

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		4 GLY A 139
GLY A 185
PHE A 186
LEU A 187
 None
 0.56A 1d0vA-1chkA:
undetectable		 1d0vA-1chkA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 GLY A 194
GLY A 222
SER A 219
GLY A 224
 None
 0.70A 1d0vA-1cjxA:
undetectable		 1d0vA-1cjxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		4 GLY A 117
GLY A  15
PHE A 148
GLY A  17
 NAP  A 191 (-3.3A)
MBO  A 201 ( 4.2A)
None
NAP  A 191 (-3.6A)
 0.74A 1d0vA-1dr6A:
undetectable		 1d0vA-1dr6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		4 GLY A 213
LEU A 227
SER A 199
GLY A 193
 None
None
None
PLP  A 401 (-3.6A)
 0.76A 1d0vA-1j0aA:
undetectable		 1d0vA-1j0aA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		6 THR A 168
GLY A 190
GLY A 251
PHE A 252
SER A 278
GLY A 303
 None
 0.46A 1d0vA-1j33A:
47.1		 1d0vA-1j33A:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.57A 1d0vA-1jftA:
undetectable		 1d0vA-1jftA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 GLY A 246
GLY A 199
PHE A 200
GLY A 195
 None
 0.64A 1d0vA-1jhzA:
undetectable		 1d0vA-1jhzA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		4 THR A 138
GLY A 134
GLY A 355
GLY A 106
 None
None
CL  A 503 (-3.5A)
None
 0.70A 1d0vA-1kplA:
undetectable		 1d0vA-1kplA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLY A 279
GLY A 259
LEU A 315
GLY A 256
 None
PLP  A1110 (-3.6A)
None
PLP  A1110 (-3.2A)
 0.75A 1d0vA-1m54A:
undetectable		 1d0vA-1m54A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 GLY A  19
GLY A  24
SER A  63
GLY A  37
 None
 0.72A 1d0vA-1pyfA:
undetectable		 1d0vA-1pyfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 GLY A 100
GLY A 133
LEU A 155
GLY A 151
 None
 0.70A 1d0vA-1rf5A:
undetectable		 1d0vA-1rf5A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		4 THR A 246
GLY A  49
GLY A 241
ARG A  53
 None
 0.54A 1d0vA-1sezA:
undetectable		 1d0vA-1sezA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		4 GLY A 117
GLY A  15
PHE A 148
GLY A  17
 NDP  A 188 (-2.3A)
None
None
NDP  A 188 ( 3.9A)
 0.72A 1d0vA-1u70A:
undetectable		 1d0vA-1u70A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Enterococcus
faecalis) 		PF02504
(FA_synthesis) 		4 THR A 190
GLY A 186
GLY A 207
LEU A 176
 None
 0.77A 1d0vA-1u7nA:
undetectable		 1d0vA-1u7nA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 277
GLY A 179
LEU A 190
GLY A 188
 None
 0.75A 1d0vA-1v10A:
undetectable		 1d0vA-1v10A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 GLY A 323
PHE A 324
LEU A 325
ARG A 296
 None
 0.72A 1d0vA-2acvA:
3.2		 1d0vA-2acvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 THR A 241
GLY A 413
GLY A 296
GLY A 202
 None
 0.61A 1d0vA-2bmoA:
undetectable		 1d0vA-2bmoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		4 GLY A 356
GLY A 327
PHE A 326
GLY A 331
 SO4  A1408 ( 3.9A)
None
None
None
 0.72A 1d0vA-2bwmA:
undetectable		 1d0vA-2bwmA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium) 		PF02458
(Transferase) 		4 GLY A 449
GLY A 338
PHE A 339
SER A 285
 None
 0.74A 1d0vA-2e1tA:
undetectable		 1d0vA-2e1tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 GLY A 394
GLY A 339
PHE A 338
GLY A 611
 None
 0.77A 1d0vA-2eidA:
undetectable		 1d0vA-2eidA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		4 THR A 236
GLY A 293
GLY A 231
GLY A 213
 None
None
K  A 369 ( 4.7A)
GOL  A 370 (-3.6A)
 0.73A 1d0vA-2hoeA:
undetectable		 1d0vA-2hoeA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m48 E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Drosophila
melanogaster) 		PF01485
(IBR) 		4 THR A 372
GLY A 378
GLY A 388
PHE A 381
 None
 0.73A 1d0vA-2m48A:
undetectable		 1d0vA-2m48A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		4 THR A  59
GLY A  38
PHE A  35
ARG A  33
 None
None
None
GG9  A 501 (-2.8A)
 0.74A 1d0vA-2pqdA:
undetectable		 1d0vA-2pqdA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 GLY A  93
GLY A 272
LEU A 274
SER A  11
 None
 0.67A 1d0vA-2qc3A:
2.3		 1d0vA-2qc3A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 THR A 129
GLY A 156
PHE A 130
GLY A 390
 None
 0.72A 1d0vA-2qfrA:
undetectable		 1d0vA-2qfrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC

(Escherichia
coli) 		PF01032
(FecCD) 		4 THR A 129
GLY A 240
GLY A  92
GLY A  96
 None
 0.76A 1d0vA-2qi9A:
undetectable		 1d0vA-2qi9A:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLY A 351
GLY A 384
SER A 341
GLY A 371
 None
GOL  A 804 (-3.6A)
None
None
 0.58A 1d0vA-2qk4A:
undetectable		 1d0vA-2qk4A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsd UNCHARACTERIZED
CONSERVED PROTEIN

(Idiomarina
loihiensis) 		PF07566
(DUF1543) 		4 GLY A  19
GLY A  15
LEU A  24
GLY A  48
 None
 0.65A 1d0vA-2qsdA:
undetectable		 1d0vA-2qsdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Streptococcus
mutans) 		PF01182
(Glucosamine_iso) 		4 THR A  38
GLY A 124
GLY A 191
PHE A 190
 None
 0.70A 1d0vA-2ri0A:
undetectable		 1d0vA-2ri0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLY A 343
GLY A 375
SER A 333
GLY A 362
 None
 0.75A 1d0vA-2xd4A:
undetectable		 1d0vA-2xd4A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 THR A 184
GLY A 421
GLY A 144
GLY A 162
 None
 0.64A 1d0vA-2y27A:
undetectable		 1d0vA-2y27A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLY A 343
GLY A 377
SER A 333
GLY A 364
 None
 0.72A 1d0vA-2yw2A:
undetectable		 1d0vA-2yw2A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		4 GLY A 161
LEU A 118
ARG A 155
GLY A 159
 None
 0.63A 1d0vA-3a9lA:
undetectable		 1d0vA-3a9lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		4 THR A  79
GLY A  45
GLY A 383
GLY A 375
 ADP  A 411 (-3.6A)
ADP  A 411 (-3.5A)
None
ADP  A 411 ( 4.4A)
 0.75A 1d0vA-3c4nA:
undetectable		 1d0vA-3c4nA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 368
GLY A  38
PHE A  37
GLY A 318
 None
 0.70A 1d0vA-3dfhA:
undetectable		 1d0vA-3dfhA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		4 GLY A 118
PHE A 119
LEU A 120
ARG A 112
 EDO  A 452 ( 4.0A)
None
None
EDO  A 474 (-3.8A)
 0.74A 1d0vA-3eu8A:
undetectable		 1d0vA-3eu8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 THR A 200
GLY A 181
GLY A 165
GLY A 158
 None
 0.77A 1d0vA-3g77A:
2.9		 1d0vA-3g77A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00694
(Aconitase_C) 		4 GLY A  98
GLY A  68
PHE A  71
SER A  94
 None
 0.67A 1d0vA-3h5jA:
undetectable		 1d0vA-3h5jA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		4 GLY A  34
GLY A   8
PHE A   7
GLY A  17
 None
 0.71A 1d0vA-3hfqA:
undetectable		 1d0vA-3hfqA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT
NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 THR D  60
GLY D  45
GLY C 109
GLY C  33
 FES  D 908 (-4.2A)
FES  D 908 ( 3.2A)
FAD  C 900 ( 3.8A)
FAD  C 900 (-3.3A)
 0.66A 1d0vA-3hrdD:
undetectable		 1d0vA-3hrdD:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih6 PUTATIVE ZINC
PROTEASE

(Bordetella
pertussis) 		PF05193
(Peptidase_M16_C) 		4 GLY A 342
PHE A 341
LEU A 313
ARG A 440
 None
 0.67A 1d0vA-3ih6A:
undetectable		 1d0vA-3ih6A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 GLY A 301
PHE A 298
SER A 113
GLY A 181
 None
 0.69A 1d0vA-3il7A:
undetectable		 1d0vA-3il7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7t MACROPHAGE BINDING
PROTEIN

(Coccidioides
immitis) 		PF01965
(DJ-1_PfpI) 		4 THR A 233
GLY A 138
GLY A 103
GLY A 135
 None
 0.71A 1d0vA-3n7tA:
3.7		 1d0vA-3n7tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		4 GLY A 186
GLY A 200
PHE A 201
SER A 167
 None
 0.68A 1d0vA-3o75A:
undetectable		 1d0vA-3o75A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on3 KETO/OXOACID
FERREDOXIN
OXIDOREDUCTASE,
GAMMA SUBUNIT

(Geobacter
sulfurreducens) 		PF01558
(POR) 		4 PHE A   9
LEU A  74
SER A  53
GLY A  11
 None
 0.77A 1d0vA-3on3A:
undetectable		 1d0vA-3on3A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLY A 438
GLY A 521
LEU A 503
GLY A 505
 None
None
None
GOL  A 529 ( 4.3A)
 0.75A 1d0vA-3pqsA:
undetectable		 1d0vA-3pqsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE

(Mycobacteroides
abscessus) 		PF00557
(Peptidase_M24) 		4 GLY A 176
PHE A 175
LEU A 220
ARG A 165
 None
 0.70A 1d0vA-3tavA:
undetectable		 1d0vA-3tavA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE

(Sphaerobacter
thermophilus) 		PF00583
(Acetyltransf_1) 		5 THR A 234
GLY A 250
GLY A 237
LEU A 236
GLY A 247
 None
 1.26A 1d0vA-3tt2A:
undetectable		 1d0vA-3tt2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN

(Sinorhizobium
meliloti) 		PF08534
(Redoxin) 		4 THR A  48
GLY A 147
GLY A 153
SER A 152
 None
 0.75A 1d0vA-3umaA:
undetectable		 1d0vA-3umaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 GLY A 168
GLY A  82
PHE A  83
GLY A 135
 None
 0.74A 1d0vA-3wc3A:
undetectable		 1d0vA-3wc3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 237
GLY A  50
LEU A  48
GLY A 167
 None
None
CSX  A  35 ( 4.4A)
None
 0.69A 1d0vA-4akoA:
undetectable		 1d0vA-4akoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 THR A 121
GLY A 103
SER A 556
GLY A 598
 None
 0.71A 1d0vA-4cvcA:
undetectable		 1d0vA-4cvcA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 THR A 928
GLY A 933
PHE A 930
GLY A 893
 None
 0.77A 1d0vA-4fysA:
undetectable		 1d0vA-4fysA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 THR A 605
GLY A 602
GLY A 559
SER A 562
 None
 0.74A 1d0vA-4g9iA:
undetectable		 1d0vA-4g9iA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		4 GLY A 199
GLY A 231
SER A 290
GLY A 229
 None
 0.66A 1d0vA-4jn6A:
2.7		 1d0vA-4jn6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k29 ENOYL-COA
HYDRATASE/ISOMERASE

(Xanthobacter
autotrophicus) 		PF00378
(ECH_1) 		4 GLY A 140
LEU A 137
SER A 242
GLY A 142
 None
 0.77A 1d0vA-4k29A:
undetectable		 1d0vA-4k29A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 THR A 297
GLY A 285
SER A 382
GLY A 300
 None
 0.77A 1d0vA-4kg7A:
2.7		 1d0vA-4kg7A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		4 THR A 178
GLY A 186
ARG A 215
GLY A 218
 None
 0.75A 1d0vA-4kkmA:
undetectable		 1d0vA-4kkmA:
22.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		7 THR A 180
GLY A 202
GLY A 264
PHE A 265
LEU A 266
ARG A 314
GLY A 316
 SO4  A 402 (-2.9A)
SO4  A 402 (-3.6A)
None
None
None
None
None
 0.42A 1d0vA-4kqkA:
62.7		 1d0vA-4kqkA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		7 THR A 180
GLY A 202
GLY A 264
PHE A 265
SER A 291
ARG A 314
GLY A 316
 SO4  A 402 (-2.9A)
SO4  A 402 (-3.6A)
None
None
None
None
None
 0.41A 1d0vA-4kqkA:
62.7		 1d0vA-4kqkA:
98.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		4 GLY A 284
GLY A  28
SER A 263
GLY A  24
 None
 0.72A 1d0vA-4ldsA:
undetectable		 1d0vA-4ldsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		4 THR A 191
GLY A 257
GLY A 246
GLY A 250
 None
 0.66A 1d0vA-4mnrA:
undetectable		 1d0vA-4mnrA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		4 GLY A  86
LEU A  74
SER A  33
GLY A  91
 None
None
CL  A 403 (-4.6A)
None
 0.72A 1d0vA-4n6dA:
undetectable		 1d0vA-4n6dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A4535
GLY A4448
PHE A4447
GLY A4451
 None
 0.69A 1d0vA-4opeA:
undetectable		 1d0vA-4opeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		4 GLY A 218
GLY A  58
PHE A 570
SER A  61
 None
 0.74A 1d0vA-4p05A:
undetectable		 1d0vA-4p05A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Vibrio cholerae) 		PF00926
(DHBP_synthase) 		5 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.89A 1d0vA-4p8eA:
undetectable		 1d0vA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wec SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 THR A 239
GLY A 171
GLY A 135
GLY A 178
 None
 0.74A 1d0vA-4wecA:
3.7		 1d0vA-4wecA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00144
(Beta-lactamase) 		4 GLY A 297
GLY A 183
PHE A 185
GLY A 248
 None
 0.69A 1d0vA-4x68A:
undetectable		 1d0vA-4x68A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		5 THR A  78
GLY A 381
LEU A 383
ARG A 377
GLY A 385
 None
 1.34A 1d0vA-4yn5A:
2.7		 1d0vA-4yn5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A2638
GLY A2551
PHE A2550
GLY A2554
 None
 0.73A 1d0vA-4z37A:
undetectable		 1d0vA-4z37A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 THR A 312
GLY A 227
GLY A 309
PHE A 310
 None
None
None
ACT  A 406 (-3.5A)
 0.61A 1d0vA-5az0A:
undetectable		 1d0vA-5az0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 GLY A 222
PHE A 221
SER A 219
GLY A 214
 None
C  B  15 ( 3.7A)
C  B  67 ( 2.5A)
C  B  15 ( 3.4A)
 0.62A 1d0vA-5czzA:
undetectable		 1d0vA-5czzA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 THR A 123
GLY A  15
GLY A  63
PHE A 113
 None
 0.73A 1d0vA-5d0fA:
undetectable		 1d0vA-5d0fA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A 325
GLY A 238
PHE A 237
GLY A 241
 None
 0.74A 1d0vA-5erbA:
undetectable		 1d0vA-5erbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 THR A 320
GLY A 325
GLY A 238
GLY A 241
 None
 0.70A 1d0vA-5erbA:
undetectable		 1d0vA-5erbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1u 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00701
(DHDPS) 		4 THR A 222
GLY A   8
GLY A 202
LEU A 199
 None
 0.74A 1d0vA-5f1uA:
undetectable		 1d0vA-5f1uA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 4 GLY A  16
GLY A 127
SER A 167
GLY A 129
 None
 0.77A 1d0vA-5fsbA:
undetectable		 1d0vA-5fsbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 4 GLY A  91
GLY A 205
SER A  14
GLY A 207
 None
 0.71A 1d0vA-5fsbA:
undetectable		 1d0vA-5fsbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		5 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.13A 1d0vA-5g0aA:
undetectable		 1d0vA-5g0aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjn LYSINE/ORNITHINE
DECARBOXYLASE

(Selenomonas
ruminantium) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLY A 319
PHE A 318
LEU A 285
GLY A 288
 None
 0.75A 1d0vA-5gjnA:
undetectable		 1d0vA-5gjnA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		4 GLY A 119
GLY A 242
LEU A 245
GLY A 128
 SR  A 402 ( 4.6A)
None
None
None
 0.77A 1d0vA-5hxsA:
undetectable		 1d0vA-5hxsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnq PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

([Clostridium]
bolteae) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		5 GLY A 216
PHE A 217
LEU A 214
SER A  16
GLY A 212
 None
 1.06A 1d0vA-5jnqA:
undetectable		 1d0vA-5jnqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 292
GLY A 152
LEU A  87
GLY A 133
 None
 0.75A 1d0vA-5k1sA:
3.2		 1d0vA-5k1sA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9o DEOXYFRUCTOSYL-AMINO
ACID TRANSPORTER
PERIPLASMIC BINDING
PROTEIN

(Agrobacterium
fabrum) 		PF00497
(SBP_bac_3) 		4 THR A 140
GLY A 144
LEU A 190
GLY A 193
 None
 0.75A 1d0vA-5l9oA:
undetectable		 1d0vA-5l9oA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT

(Xanthobacter
autotrophicus) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 GLY B 285
GLY B 311
SER B 314
GLY B  20
 None
AMP  B 801 (-3.5A)
None
AMP  B 801 ( 3.7A)
 0.75A 1d0vA-5m45B:
1.7		 1d0vA-5m45B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 4 GLY A  96
GLY A 175
PHE A 174
GLY A   4
 None
 0.69A 1d0vA-5n7qA:
undetectable		 1d0vA-5n7qA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		4 THR J 389
GLY J 374
GLY J 381
PHE J 377
 None
 0.74A 1d0vA-5nilJ:
undetectable		 1d0vA-5nilJ:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 GLY A 109
GLY A 190
PHE A 107
GLY A 192
 None
 0.74A 1d0vA-5t98A:
undetectable		 1d0vA-5t98A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 GLY A  94
GLY A2265
SER A2268
GLY A2238
 None
 0.73A 1d0vA-5tzyA:
undetectable		 1d0vA-5tzyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 THR A 212
GLY A 138
GLY A 332
GLY A 355
 NAD  A 501 ( 4.1A)
SAH  A 502 ( 3.9A)
NAD  A 501 (-3.5A)
NAD  A 501 (-3.4A)
 0.76A 1d0vA-5utuA:
2.6		 1d0vA-5utuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCD

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 GLY B 185
GLY B 162
SER B 164
GLY B 120
 None
 0.74A 1d0vA-5vipB:
undetectable		 1d0vA-5vipB:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 THR A 241
GLY A 413
GLY A 296
GLY A 202
 None
 0.60A 1d0vA-5xbpA:
undetectable		 1d0vA-5xbpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE

(Bacillus
licheniformis) 		no annotation 4 GLY A  86
GLY A 149
LEU A 150
SER A 108
 GLY  A  86 ( 0.0A)
GLY  A 149 ( 0.0A)
LEU  A 150 ( 0.6A)
SER  A 108 ( 0.0A)
 0.71A 1d0vA-5xluA:
undetectable		 1d0vA-5xluA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 THR A 407
GLY A 352
GLY A 380
GLY A 348
 None
 0.69A 1d0vA-5xyaA:
2.9		 1d0vA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 4 GLY A 510
PHE A 476
SER A 469
GLY A 513
 None
 0.71A 1d0vA-5z0uA:
undetectable		 1d0vA-5z0uA:
9.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 8 THR A 179
GLY A 201
GLY A 263
PHE A 264
LEU A 265
SER A 290
ARG A 313
GLY A 315
 SO4  A 401 (-2.8A)
SO4  A 401 ( 3.7A)
None
None
None
None
None
None
 0.35A 1d0vA-6b5fA:
59.4		 1d0vA-6b5fA:
67.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 339
GLY A  34
LEU A  33
GLY A  37
 None
 0.68A 1d0vA-6c6lA:
undetectable		 1d0vA-6c6lA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 4 THR A 285
GLY A 557
GLY A 230
GLY A 234
 None
None
FAD  A 601 (-3.3A)
None
 0.77A 1d0vA-6f72A:
undetectable		 1d0vA-6f72A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 GLY A1759
GLY A1727
LEU A1728
GLY A2013
 None
 0.68A 1d0vA-6fayA:
undetectable		 1d0vA-6fayA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft1 FLAVODOXIN

(Bacillus cereus) 		no annotation 4 GLY A  13
GLY A  56
PHE A   8
GLY A  90
 FMN  A1001 (-4.0A)
None
None
None
 0.76A 1d0vA-6ft1A:
undetectable		 1d0vA-6ft1A:
13.51