SIMILAR PATTERNS OF AMINO ACIDS FOR 1CRB_A_RTLA200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7o IGG1-KAPPA D1.3 FV
(LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		5 PHE L  83
LEU L 104
LEU L  11
ALA L  13
ILE L  75
 None
 1.14A 1crbA-1a7oL:
undetectable		 1crbA-1a7oL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 LEU A 399
LEU A 402
ALA A 406
ILE A 424
ILE A 436
 None
 1.04A 1crbA-1c30A:
undetectable		 1crbA-1c30A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		6 LEU A 216
LEU A 213
ALA A 212
LEU A  23
ILE A  34
ILE A   6
 None
 1.29A 1crbA-1ecgA:
0.0		 1crbA-1ecgA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f89 32.5 KDA PROTEIN
YLR351C

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		5 LEU A  83
LEU A  29
ALA A  32
LEU A  18
ILE A  99
 None
 1.10A 1crbA-1f89A:
undetectable		 1crbA-1f89A:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 LEU A  20
ALA A  33
LEU A  36
LYS A  40
THR A  53
ARG A  58
TRP A 106
 None
 0.82A 1crbA-1gglA:
20.7		 1crbA-1gglA:
55.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		5 LEU B  58
LEU B  94
ALA B  51
ILE B 161
ILE B  36
 None
 1.11A 1crbA-1jwaB:
0.1		 1crbA-1jwaB:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		5 ALA A  33
LEU A  36
THR A  53
ARG A  58
TRP A 106
 None
 1.08A 1crbA-1kqxA:
21.5		 1crbA-1kqxA:
59.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		6 PHE A  16
ALA A  33
LEU A  36
LYS A  40
THR A  53
TRP A 106
 None
 0.74A 1crbA-1kqxA:
21.5		 1crbA-1kqxA:
59.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE

(Pseudomonas sp.
CBS3) 		no annotation 5 LEU A  44
ILE A  80
THR A  82
ARG A   3
MET A   7
 None
 1.01A 1crbA-1lo9A:
1.0		 1crbA-1lo9A:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		7 ALA A  33
LEU A  36
LYS A  40
ILE A  51
THR A  53
ARG A  58
TRP A 106
 None
 0.69A 1crbA-1lpjA:
20.5		 1crbA-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  16
ALA A  33
LEU A  36
ILE A  51
THR A  53
ARG A  58
TRP A 106
 None
 0.54A 1crbA-1lpjA:
20.5		 1crbA-1lpjA:
56.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mr2 ADPR PYROPHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00293
(NUDIX) 		5 LEU A  94
LEU A 130
ALA A 127
LEU A 126
ILE A 164
 None
 1.13A 1crbA-1mr2A:
undetectable		 1crbA-1mr2A:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
ALA A  33
LEU A  36
ILE A  51
THR A  53
ARG A  58
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.3A)
None
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 1.01A 1crbA-1mx8A:
20.4		 1crbA-1mx8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
ALA A  33
LEU A  36
LYS A  40
ILE A  51
ARG A  58
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
None
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.95A 1crbA-1mx8A:
20.4		 1crbA-1mx8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
LEU A  20
LEU A  29
ALA A  33
LEU A  36
LYS A  40
ILE A  51
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.7A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
 0.78A 1crbA-1mx8A:
20.4		 1crbA-1mx8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
LEU A  29
ALA A  33
LEU A  36
ILE A  51
THR A  53
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.3A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.95A 1crbA-1mx8A:
20.4		 1crbA-1mx8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
LEU A  29
ALA A  33
LEU A  36
LYS A  40
ILE A  51
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.92A 1crbA-1mx8A:
20.4		 1crbA-1mx8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og0 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Saccharomyces
cerevisiae) 		PF00793
(DAHP_synth_1) 		5 PHE A 145
LEU A 168
LEU A 138
ALA A 141
LEU A 122
 None
 1.15A 1crbA-1og0A:
undetectable		 1crbA-1og0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		5 PHE A 162
LEU A 120
LEU A 117
LEU A  64
ILE A  84
 CSR  A  80 ( 3.5A)
None
None
None
CSR  A  80 ( 3.6A)
 1.14A 1crbA-1okgA:
undetectable		 1crbA-1okgA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN
ECDYSONE RECEPTOR

(Heliothis
virescens;
Heliothis
virescens) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 LEU D 491
LEU A 419
ALA A 415
ILE D 298
THR D 468
 None
 1.15A 1crbA-1r20D:
undetectable		 1crbA-1r20D:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN
ECDYSONE RECEPTOR

(Heliothis
virescens;
Heliothis
virescens) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE D 487
LEU D 491
ALA A 415
ILE D 298
ILE D 443
 None
 1.02A 1crbA-1r20D:
undetectable		 1crbA-1r20D:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN
ECDYSONE RECEPTOR

(Heliothis
virescens;
Heliothis
virescens) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE D 487
LEU D 491
LEU A 419
ALA A 415
ILE D 298
 None
 0.96A 1crbA-1r20D:
undetectable		 1crbA-1r20D:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		5 LEU A 165
LEU A  79
ALA A 168
ILE A 266
MET A 236
 None
 1.08A 1crbA-1ypxA:
undetectable		 1crbA-1ypxA:
16.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		5 LEU A  19
ALA A  32
ILE A  63
THR A  61
TRP A 109
 None
A80  A 201 ( 4.1A)
None
None
None
 0.89A 1crbA-2cbrA:
15.7		 1crbA-2cbrA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  15
ALA A  32
ILE A  52
THR A  54
TRP A 109
 None
A80  A 201 ( 4.1A)
None
A80  A 201 (-3.5A)
None
 0.82A 1crbA-2cbrA:
15.7		 1crbA-2cbrA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  15
LEU A  19
ALA A  32
ILE A  52
TRP A 109
 None
None
A80  A 201 ( 4.1A)
None
None
 0.94A 1crbA-2cbrA:
15.7		 1crbA-2cbrA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  15
LEU A  19
ALA A  32
ILE A  63
TRP A 109
 None
None
A80  A 201 ( 4.1A)
None
None
 0.90A 1crbA-2cbrA:
15.7		 1crbA-2cbrA:
42.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyl ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF06400
(Alpha-2-MRAP_N) 		5 LEU A  45
LEU A  28
ALA A  32
LEU A  35
ILE A  84
 None
 1.14A 1crbA-2fylA:
undetectable		 1crbA-2fylA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		5 LEU A  96
LEU A  39
ALA A 404
LEU A 405
ILE A 396
 None
 0.97A 1crbA-2g02A:
undetectable		 1crbA-2g02A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		5 LEU A  94
LEU A  61
ALA A  70
LEU A  73
ILE A 168
 None
CAA  A1751 (-3.9A)
None
None
None
 1.16A 1crbA-2gd2A:
undetectable		 1crbA-2gd2A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		5 PHE A  45
LEU A  36
ALA A  37
LEU A  42
ILE A 323
 None
 1.12A 1crbA-2i7gA:
undetectable		 1crbA-2i7gA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		5 PHE A 291
LEU A 287
LEU A 409
ILE A 397
MET A 392
 None
 1.12A 1crbA-2iy8A:
undetectable		 1crbA-2iy8A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt4 RESPONSE REGULATOR
HOMOLOG

(Myxococcus
xanthus) 		PF00072
(Response_reg) 		5 LEU A  22
LEU A 112
ALA A 116
LEU A 119
ILE A   7
 None
 1.05A 1crbA-2nt4A:
undetectable		 1crbA-2nt4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ULTRASPIRACLE (USP,
NR2B4)
ECDYSONE RECEPTOR
(ECR, NRH1)

(Tribolium
castaneum;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE E 504
LEU E 508
ALA A 362
ILE E 319
ILE E 462
 None
 1.08A 1crbA-2nxxE:
undetectable		 1crbA-2nxxE:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 134
ALA A 145
ILE A 109
THR A 111
ARG A 166
 None
 1.07A 1crbA-2pk3A:
undetectable		 1crbA-2pk3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 LEU A 257
LEU A 311
ALA A 334
LEU A 331
ILE A  24
 None
 0.92A 1crbA-2pqdA:
undetectable		 1crbA-2pqdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		5 LEU A 338
ALA A 185
THR A 197
MET A  61
ILE A 325
 None
 1.10A 1crbA-2qp2A:
undetectable		 1crbA-2qp2A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq0 THYMIDINE KINASE

(Thermotoga
maritima) 		PF00265
(TK) 		5 LEU A 127
ALA A 130
LEU A   5
ILE A  26
ILE A 134
 None
 1.03A 1crbA-2qq0A:
undetectable		 1crbA-2qq0A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
ALA A  33
LYS A  40
THR A  53
ARG A  58
TRP A 106
 None
None
None
None
SO4  A 152 (-3.1A)
None
 0.80A 1crbA-2rcqA:
21.2		 1crbA-2rcqA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf7 CYTOCHROME C-552

(Escherichia
coli) 		PF02335
(Cytochrom_C552) 		5 LEU A 420
LEU A 416
ALA A 357
LEU A 358
ILE A 429
 None
 1.08A 1crbA-2rf7A:
undetectable		 1crbA-2rf7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 PHE A 144
LEU A 148
ALA A  72
LEU A  71
ILE A  97
 None
 0.92A 1crbA-2vdcA:
2.5		 1crbA-2vdcA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		5 LEU A 250
LEU A  31
ALA A  75
ILE A  65
ILE A  35
 None
 1.10A 1crbA-2vfwA:
undetectable		 1crbA-2vfwA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2i 2-OXOGLUTARATE
OXYGENASE

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		5 PHE A 238
LEU A 239
LEU A 220
ALA A 224
LEU A 227
 None
 1.12A 1crbA-2w2iA:
undetectable		 1crbA-2w2iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykq LINE-1 ORF1P

(Homo sapiens) 		PF02994
(Transposase_22)
PF17489
(Tnp_22_trimer)
PF17490
(Tnp_22_dsRBD) 		5 PHE A 186
ALA A 234
LEU A 231
ILE A 200
ILE A 247
 None
 1.06A 1crbA-2ykqA:
undetectable		 1crbA-2ykqA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A  12
LEU A  27
ALA A  25
ILE A 264
THR A 266
 None
 0.91A 1crbA-3aupA:
undetectable		 1crbA-3aupA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bil PROBABLE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF13407
(Peripla_BP_4) 		5 PHE A 205
LEU A 218
ILE A 332
THR A 243
ILE A 214
 None
 1.12A 1crbA-3bilA:
undetectable		 1crbA-3bilA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  49
LEU A  46
ALA A 426
THR A 216
MET A 152
 None
 1.04A 1crbA-3ce6A:
undetectable		 1crbA-3ce6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 220
LEU A 168
LEU A 165
ALA A 164
ILE A 300
 None
 1.13A 1crbA-3d5tA:
undetectable		 1crbA-3d5tA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 3
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00022
(Actin)
PF04045
(P34-Arc) 		5 LEU D   4
LEU A  72
ILE A 145
MET A 146
TRP A 109
 None
 1.06A 1crbA-3dwlD:
undetectable		 1crbA-3dwlD:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		5 PHE A 185
ALA A 158
ILE A 149
THR A 151
MET A 221
 None
 1.12A 1crbA-3e8sA:
undetectable		 1crbA-3e8sA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  67
LEU A  64
LEU A  29
LYS A 398
ILE A 369
 None
 0.95A 1crbA-3g1uA:
undetectable		 1crbA-3g1uA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  77
LEU A  74
LEU A  39
LYS A 434
ILE A 411
 None
 1.00A 1crbA-3glqA:
undetectable		 1crbA-3glqA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i83 2-DEHYDROPANTOATE
2-REDUCTASE

(Methylococcus
capsulatus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 PHE A 166
LEU A 162
ALA A 165
ILE A  42
ILE A   3
 None
 1.10A 1crbA-3i83A:
undetectable		 1crbA-3i83A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus) 		PF00346
(Complex1_49kDa) 		5 LEU 4 133
ALA 4 149
ILE 4 290
ARG 4 200
ILE 4 201
 None
 1.14A 1crbA-3i9v4:
undetectable		 1crbA-3i9v4:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 PHE A 404
LEU A 396
ALA A 400
ILE A 515
ILE A 542
 None
 1.15A 1crbA-3ibjA:
undetectable		 1crbA-3ibjA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 PHE A1174
LEU A1197
ALA A1176
LEU A1113
ILE A1135
 None
 1.13A 1crbA-3kg7A:
2.7		 1crbA-3kg7A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		5 PHE A 253
LEU A 249
LEU A  69
ALA A 252
ILE A 240
 None
 0.92A 1crbA-3kn1A:
undetectable		 1crbA-3kn1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  70
LEU A  67
LEU A  32
LYS A 427
ILE A 404
 None
 1.03A 1crbA-3n58A:
undetectable		 1crbA-3n58A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 PHE A 392
LEU A 396
LEU A 354
ILE A  89
ILE A 366
 None
 0.97A 1crbA-3otrA:
undetectable		 1crbA-3otrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR

(Shewanella
loihica) 		PF00440
(TetR_N) 		5 PHE A 187
LEU A  81
ALA A  85
LEU A  88
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
PG4  A 216 (-3.8A)
None
 0.90A 1crbA-3ppbA:
undetectable		 1crbA-3ppbA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR

(Shewanella
loihica) 		PF00440
(TetR_N) 		5 PHE A 187
LEU A  81
ALA A  85
MET A 124
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
None
None
 1.08A 1crbA-3ppbA:
undetectable		 1crbA-3ppbA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti) 		PF03486
(HI0933_like) 		5 PHE A 365
LEU A 184
ALA A 357
ILE A 133
ARG A 138
 None
 1.14A 1crbA-3v76A:
undetectable		 1crbA-3v76A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 PHE A3920
LEU A3924
ALA A3801
LEU A3798
ILE A3974
 None
 1.02A 1crbA-3vkgA:
undetectable		 1crbA-3vkgA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		5 LEU A 107
ALA A  71
LEU A  12
ILE A 316
ILE A 110
 None
 1.05A 1crbA-3vpzA:
undetectable		 1crbA-3vpzA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		5 LEU A 160
LEU A 120
ALA A  92
ILE A 176
ILE A 156
 None
 1.10A 1crbA-3w7bA:
undetectable		 1crbA-3w7bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag2 FYNOMER

(synthetic
construct) 		PF00018
(SH3_1) 		5 LEU C  30
ALA C  40
LEU C  19
THR C  44
ARG C  41
 None
 1.14A 1crbA-4ag2C:
undetectable		 1crbA-4ag2C:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Leishmania
major) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A 180
LEU A 184
ALA A 124
LEU A 122
ILE A  52
 MG  A 999 ( 4.3A)
None
None
None
None
 1.01A 1crbA-4cgnA:
undetectable		 1crbA-4cgnA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcz BLUE-LIGHT
PHOTORECEPTOR,
SENSOR PROTEIN FIXL

(Bacillus
subtilis;
Bradyrhizobium
diazoefficiens) 		PF00512
(HisKA)
PF02518
(HATPase_c)
PF13426
(PAS_9) 		5 LEU A 292
LEU A 281
ALA A 280
ILE A 269
ARG A 278
 None
None
ADP  A 402 ( 4.3A)
None
None
 1.09A 1crbA-4gczA:
0.9		 1crbA-4gczA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqb PROTEIN H03A11.1

(Caenorhabditis
elegans) 		PF06702
(Fam20C) 		5 PHE A 392
LEU A 447
LEU A 438
ALA A 220
ILE A 462
 None
 1.08A 1crbA-4kqbA:
undetectable		 1crbA-4kqbA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.93A 1crbA-4okrA:
undetectable		 1crbA-4okrA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.95A 1crbA-4okuA:
undetectable		 1crbA-4okuA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owr MRNA EXPORT FACTOR

(Homo sapiens) 		PF00400
(WD40) 		5 PHE A 330
LEU A  45
ALA A 331
LEU A 355
ILE A 318
 None
 1.07A 1crbA-4owrA:
undetectable		 1crbA-4owrA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR

(Pediculus
humanus;
Pediculus
humanus) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE E 477
LEU E 481
ALA U 349
ILE E 292
ILE E 435
 None
 1.01A 1crbA-4oztE:
undetectable		 1crbA-4oztE:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR

(Pediculus
humanus;
Pediculus
humanus) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE E 477
LEU E 481
LEU U 353
ALA U 349
ILE E 292
 None
 0.95A 1crbA-4oztE:
undetectable		 1crbA-4oztE:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pys BETA-N-ACETYLHEXOSAM
INIDASE

(Bacteroides
fragilis) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 PHE A 352
LEU A 364
ALA A 340
ILE A 270
ARG A 338
 None
 1.08A 1crbA-4pysA:
undetectable		 1crbA-4pysA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora) 		PF08801
(Nucleoporin_N) 		5 PHE A 350
LEU A 348
ALA A 368
LEU A 367
ILE A 384
 None
 1.12A 1crbA-4q9tA:
3.3		 1crbA-4q9tA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		5 LEU A 158
LEU A 177
ALA A 173
LEU A 170
THR A 281
 None
 1.16A 1crbA-4rjzA:
undetectable		 1crbA-4rjzA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 198
ALA A 201
LEU A 174
THR A 236
ILE A 191
 None
 1.13A 1crbA-4uekA:
undetectable		 1crbA-4uekA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xax DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1

(Thermus
aquaticus) 		PF04563
(RNA_pol_Rpb2_1) 		5 LEU A  94
ALA A  96
LEU A  98
THR A  51
ILE A  44
 None
 1.13A 1crbA-4xaxA:
undetectable		 1crbA-4xaxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		5 LEU A 652
LEU A 657
ALA A 860
ILE A 600
ILE A 852
 None
 1.15A 1crbA-5b16A:
undetectable		 1crbA-5b16A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7n MTA/SAH NUCLEOSIDASE

(Aeromonas
hydrophila) 		PF01048
(PNP_UDP_1) 		5 LEU A  66
LEU A  48
ALA A  47
ILE A 117
ILE A  33
 None
 1.03A 1crbA-5b7nA:
undetectable		 1crbA-5b7nA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		5 PHE A  68
LEU A  50
LEU A  11
ALA A  64
ILE A  39
 None
 1.15A 1crbA-5dnyA:
undetectable		 1crbA-5dnyA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU B 269
ALA B 246
LEU B 247
ILE B 193
ILE B 241
 None
 1.05A 1crbA-5gqrB:
undetectable		 1crbA-5gqrB:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 PHE b 433
LEU b 437
ALA b 131
LEU b 132
ILE b  80
 None
 1.14A 1crbA-5gw5b:
undetectable		 1crbA-5gw5b:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Streptococcus
porcinus) 		PF01791
(DeoC) 		5 LEU A 157
LEU A 115
ALA A 120
LEU A  86
ILE A 245
 None
 1.12A 1crbA-5hjlA:
undetectable		 1crbA-5hjlA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		5 LEU A 149
ALA A 179
LEU A 182
ILE A 625
ILE A 680
 None
 1.10A 1crbA-5iw7A:
undetectable		 1crbA-5iw7A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 LEU A 691
ALA A 705
LEU A 704
THR A 746
ILE A 723
 None
 1.14A 1crbA-5l3dA:
undetectable		 1crbA-5l3dA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		5 LEU A 178
ALA A 214
LEU A 215
ILE A 204
ILE A 244
 None
 1.01A 1crbA-5ladA:
undetectable		 1crbA-5ladA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sxy BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D

(Methylobacterium
extorquens) 		PF05402
(PqqD) 		5 LEU A  83
LEU A  86
LEU A  14
ILE A  63
ILE A  79
 None
 1.05A 1crbA-5sxyA:
undetectable		 1crbA-5sxyA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN

(Thermoactinomyces
vulgaris) 		PF00668
(Condensation) 		5 ALA A 858
LEU A 861
ARG A1177
MET A1185
ILE A1176
 None
 0.99A 1crbA-5t3eA:
undetectable		 1crbA-5t3eA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 523
LEU A 582
ALA A 581
ILE A 544
ILE A 560
 None
 1.13A 1crbA-5u25A:
undetectable		 1crbA-5u25A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		5 PHE A  81
LEU A  86
LEU A 185
LEU A 359
MET A 342
 None
None
None
FAD  A 601 (-3.1A)
None
 1.02A 1crbA-5uaoA:
undetectable		 1crbA-5uaoA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens) 		PF06702
(Fam20C) 		5 PHE A 435
LEU A 490
LEU A 481
ALA A 265
ILE A 505
 None
 1.13A 1crbA-5wrrA:
undetectable		 1crbA-5wrrA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wya ISOLEUCINE
2-EPIMERASE

(Lactobacillus
buchneri) 		PF00202
(Aminotran_3) 		5 PHE A 409
LEU A 365
ALA A 343
ARG A 417
ILE A 415
 None
 1.12A 1crbA-5wyaA:
undetectable		 1crbA-5wyaA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 5 LEU A1093
LEU A1115
LEU A1065
ILE A1057
MET A 867
 None
 1.06A 1crbA-5xwyA:
undetectable		 1crbA-5xwyA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A2483
ALA A2471
ILE A2411
MET A2414
ILE A2435
 None
None
SO4  A2702 (-3.8A)
None
None
 1.12A 1crbA-5y4dA:
undetectable		 1crbA-5y4dA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  73
LEU A  70
LEU A  35
LYS A 398
ILE A 375
 None
 0.96A 1crbA-6aphA:
undetectable		 1crbA-6aphA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6baq BPI FOLD-CONTAINING
FAMILY A MEMBER 1

(Mus musculus) 		no annotation 5 LEU A 260
LEU A 256
ALA A  79
ILE A 276
ILE A 264
 None
 1.14A 1crbA-6baqA:
undetectable		 1crbA-6baqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 LEU I 251
LEU I 265
ALA I 342
LEU I 378
ILE I 259
 None
 1.11A 1crbA-6bnpI:
undetectable		 1crbA-6bnpI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 5 LEU B  41
LEU B  38
ALA B 392
THR B 162
MET B 135
 None
 1.10A 1crbA-6f3mB:
undetectable		 1crbA-6f3mB:
undetectable