SIMILAR PATTERNS OF AMINO ACIDS FOR 1CQP_B_803B311

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		4 VAL A 388
LEU A 380
LEU A 345
LEU A 425
 None
 0.74A 1cqpA-1b8gA:
2.2
1cqpB-1b8gA:
2.0		 1cqpA-1b8gA:
19.63
1cqpB-1b8gA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 LEU A 276
VAL A 279
TYR A 286
LEU A 325
 None
 0.77A 1cqpA-1bjnA:
2.0
1cqpB-1bjnA:
2.0		 1cqpA-1bjnA:
21.61
1cqpB-1bjnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 VAL A 387
LEU A 613
VAL A 621
LEU A 362
 None
 0.79A 1cqpA-1br2A:
undetectable
1cqpB-1br2A:
undetectable		 1cqpA-1br2A:
12.85
1cqpB-1br2A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE

(Bacillus
subtilis) 		PF14562
(Endonuc_BglI) 		4 VAL A 141
LEU A 121
VAL A 106
LEU A  38
 None
 0.78A 1cqpA-1dmuA:
undetectable
1cqpB-1dmuA:
undetectable		 1cqpA-1dmuA:
20.78
1cqpB-1dmuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		4 VAL A  71
LEU A  42
LEU A  22
LEU A  25
 None
 0.87A 1cqpA-1hwnA:
undetectable
1cqpB-1hwnA:
undetectable		 1cqpA-1hwnA:
24.30
1cqpB-1hwnA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 VAL N 101
VAL N  81
LEU N  50
LEU N  49
 None
 0.82A 1cqpA-1k7sN:
undetectable
1cqpB-1k7sN:
undetectable		 1cqpA-1k7sN:
20.82
1cqpB-1k7sN:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 VAL A  86
LEU A  32
VAL A  29
LEU A  42
 None
 0.88A 1cqpA-1lwhA:
undetectable
1cqpB-1lwhA:
undetectable		 1cqpA-1lwhA:
17.70
1cqpB-1lwhA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 VAL A 246
LEU A 291
VAL A 287
LEU A 230
 None
 0.70A 1cqpA-1mb9A:
undetectable
1cqpB-1mb9A:
undetectable		 1cqpA-1mb9A:
16.78
1cqpB-1mb9A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mje BREAST CANCER 2

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		4 LEU A2892
VAL A2743
TYR A2925
LEU A2915
 None
 0.83A 1cqpA-1mjeA:
undetectable
1cqpB-1mjeA:
undetectable		 1cqpA-1mjeA:
15.49
1cqpB-1mjeA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mje BREAST CANCER 2

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		4 LEU A3043
VAL A2991
LYS A3076
LEU A3012
 None
 0.81A 1cqpA-1mjeA:
undetectable
1cqpB-1mjeA:
undetectable		 1cqpA-1mjeA:
15.49
1cqpB-1mjeA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		4 VAL A 934
LEU A1155
VAL A1157
LEU A1103
 ACT  A1302 (-3.9A)
None
None
None
 0.87A 1cqpA-1mskA:
undetectable
1cqpB-1mskA:
undetectable		 1cqpA-1mskA:
17.91
1cqpB-1mskA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		4 VAL A 212
LEU A 254
VAL A 257
LEU A 245
 None
None
SAM  A 635 ( 4.7A)
None
 0.84A 1cqpA-1qzzA:
undetectable
1cqpB-1qzzA:
undetectable		 1cqpA-1qzzA:
20.06
1cqpB-1qzzA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 VAL A  64
LEU A 251
VAL A 249
LEU A 183
 None
 0.88A 1cqpA-1uzrA:
undetectable
1cqpB-1uzrA:
undetectable		 1cqpA-1uzrA:
23.61
1cqpB-1uzrA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167

(Pseudomonas
aeruginosa) 		PF08787
(Alginate_lyase2) 		4 VAL A 134
LEU A 148
LEU A 169
LEU A 170
 None
 0.72A 1cqpA-1vavA:
undetectable
1cqpB-1vavA:
undetectable		 1cqpA-1vavA:
19.91
1cqpB-1vavA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdj HYPOTHETICAL PROTEIN
TT1808

(Thermus
thermophilus) 		PF05685
(Uma2) 		4 VAL A 154
LEU A 183
VAL A 167
LEU A 172
 None
 0.78A 1cqpA-1wdjA:
undetectable
1cqpB-1wdjA:
undetectable		 1cqpA-1wdjA:
20.87
1cqpB-1wdjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqb HYPOTHETICAL UPF0066
PROTEIN HI0510

(Haemophilus
influenzae) 		PF01980
(UPF0066) 		4 VAL A  36
LEU A  51
VAL A  48
LEU A  59
 None
 0.75A 1cqpA-1xqbA:
undetectable
1cqpB-1xqbA:
undetectable		 1cqpA-1xqbA:
21.16
1cqpB-1xqbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 VAL A 154
LEU A  35
VAL A 212
LEU A 177
 None
 0.79A 1cqpA-1yq2A:
undetectable
1cqpB-1yq2A:
undetectable		 1cqpA-1yq2A:
10.38
1cqpB-1yq2A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 VAL A 395
LEU A 415
VAL A 411
LEU A 389
 None
 0.82A 1cqpA-1z6tA:
undetectable
1cqpB-1z6tA:
undetectable		 1cqpA-1z6tA:
16.18
1cqpB-1z6tA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc3 EXOCYST COMPLEX
PROTEIN EXO84

(Rattus
norvegicus) 		no annotation 4 LEU B 268
VAL B 267
TYR B 176
LEU B 180
 None
 0.81A 1cqpA-1zc3B:
undetectable
1cqpB-1zc3B:
undetectable		 1cqpA-1zc3B:
19.46
1cqpB-1zc3B:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1i PEPTIDOGLYCAN GLCNAC
DEACETYLASE

(Streptococcus
pneumoniae) 		PF01522
(Polysacc_deac_1) 		4 VAL A 301
LEU A 356
VAL A 355
LEU A 287
 None
 0.83A 1cqpA-2c1iA:
undetectable
1cqpB-2c1iA:
undetectable		 1cqpA-2c1iA:
20.29
1cqpB-2c1iA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 511
VAL A 453
TYR A 425
LEU A 362
 None
 0.84A 1cqpA-2e6kA:
undetectable
1cqpB-2e6kA:
undetectable		 1cqpA-2e6kA:
13.08
1cqpB-2e6kA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		4 LEU A 393
VAL A 422
LEU A 309
LEU A 310
 None
 0.88A 1cqpA-2grvA:
undetectable
1cqpB-2grvA:
undetectable		 1cqpA-2grvA:
14.57
1cqpB-2grvA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 450
VAL A 464
TYR A 371
LEU A 323
 None
 0.86A 1cqpA-2qt6A:
undetectable
1cqpB-2qt6A:
undetectable		 1cqpA-2qt6A:
16.99
1cqpB-2qt6A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 VAL 1 324
LEU 1 246
TYR 1 157
LEU 1 144
 None
 0.88A 1cqpA-2r6r1:
4.1
1cqpB-2r6r1:
undetectable		 1cqpA-2r6r1:
21.13
1cqpB-2r6r1:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00342
(PGI) 		4 VAL A 269
VAL A 245
LEU A 296
LEU A 103
 None
 0.89A 1cqpA-2wu8A:
undetectable
1cqpB-2wu8A:
2.7		 1cqpA-2wu8A:
16.83
1cqpB-2wu8A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrl KIAA1837 PROTEIN

(Homo sapiens) 		PF00801
(PKD) 		4 LEU A  17
VAL A  93
TYR A  71
LEU A  53
 None
 0.63A 1cqpA-2yrlA:
undetectable
1cqpB-2yrlA:
undetectable		 1cqpA-2yrlA:
24.68
1cqpB-2yrlA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrl KIAA1837 PROTEIN

(Homo sapiens) 		PF00801
(PKD) 		4 LEU A  17
VAL A  93
TYR A  71
LYS A  44
 None
 0.63A 1cqpA-2yrlA:
undetectable
1cqpB-2yrlA:
undetectable		 1cqpA-2yrlA:
24.68
1cqpB-2yrlA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywq RIBOSOMAL SUBUNIT
INTERFACE PROTEIN

(Thermus
thermophilus) 		PF02482
(Ribosomal_S30AE) 		4 VAL A  84
LEU A  42
TYR A  20
LEU A  25
 None
 0.88A 1cqpA-2ywqA:
undetectable
1cqpB-2ywqA:
undetectable		 1cqpA-2ywqA:
21.20
1cqpB-2ywqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 VAL A 252
LEU A 298
VAL A 229
LEU A 234
 None
 0.79A 1cqpA-2yxzA:
undetectable
1cqpB-2yxzA:
undetectable		 1cqpA-2yxzA:
19.35
1cqpB-2yxzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 VAL A 159
VAL A 137
LEU A  32
LEU A  77
 None
 0.77A 1cqpA-2z1aA:
undetectable
1cqpB-2z1aA:
undetectable		 1cqpA-2z1aA:
17.59
1cqpB-2z1aA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus) 		PF00128
(Alpha-amylase) 		4 VAL A  72
LEU A 102
VAL A  52
LEU A 115
 None
 0.84A 1cqpA-2z1kA:
undetectable
1cqpB-2z1kA:
undetectable		 1cqpA-2z1kA:
14.57
1cqpB-2z1kA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A  88
LEU A  29
VAL A  28
LEU A  41
 None
 0.80A 1cqpA-3a9vA:
2.7
1cqpB-3a9vA:
2.8		 1cqpA-3a9vA:
15.99
1cqpB-3a9vA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 VAL A 369
LEU A 413
VAL A 415
LEU A 358
 None
 0.86A 1cqpA-3apoA:
undetectable
1cqpB-3apoA:
undetectable		 1cqpA-3apoA:
12.75
1cqpB-3apoA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 VAL A 353
LEU A 296
VAL A 295
LEU A 257
 None
 0.81A 1cqpA-3bgaA:
undetectable
1cqpB-3bgaA:
undetectable		 1cqpA-3bgaA:
10.69
1cqpB-3bgaA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpo INTERLEUKIN 13

(Homo sapiens) 		PF03487
(IL13) 		4 VAL A  34
LEU A  28
LEU A  67
LEU A  51
 VAL  A  34 ( 0.6A)
LEU  A  28 ( 0.6A)
LEU  A  67 ( 0.6A)
LEU  A  51 ( 0.6A)
 0.82A 1cqpA-3bpoA:
undetectable
1cqpB-3bpoA:
undetectable		 1cqpA-3bpoA:
21.62
1cqpB-3bpoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa) 		PF02230
(Abhydrolase_2) 		4 LEU A  40
VAL A  39
LEU A 159
LEU A 135
 None
 0.87A 1cqpA-3cn7A:
4.2
1cqpB-3cn7A:
4.9		 1cqpA-3cn7A:
21.10
1cqpB-3cn7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		5 VAL A 108
VAL A 120
TYR A  94
LEU A 126
LEU A 125
 None
 1.11A 1cqpA-3czeA:
undetectable
1cqpB-3czeA:
undetectable		 1cqpA-3czeA:
14.96
1cqpB-3czeA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 VAL A 329
LEU A 272
VAL A 271
LEU A 233
 None
 0.89A 1cqpA-3decA:
2.0
1cqpB-3decA:
undetectable		 1cqpA-3decA:
11.64
1cqpB-3decA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4a UNCHARACTERIZED
PROTEIN YGR203W

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 VAL A  36
LEU A 118
LEU A  66
LEU A  69
 None
 0.85A 1cqpA-3f4aA:
undetectable
1cqpB-3f4aA:
undetectable		 1cqpA-3f4aA:
22.28
1cqpB-3f4aA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f51 CLP GENE REGULATOR
(CLGR)

(Corynebacterium
glutamicum) 		PF13560
(HTH_31) 		4 LEU A  72
VAL A  68
LEU A  44
LEU A  47
 None
 0.69A 1cqpA-3f51A:
undetectable
1cqpB-3f51A:
undetectable		 1cqpA-3f51A:
21.76
1cqpB-3f51A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		4 VAL A 200
LEU A 194
LEU A  54
LEU A  51
 None
 0.76A 1cqpA-3ffrA:
3.4
1cqpB-3ffrA:
3.3		 1cqpA-3ffrA:
19.89
1cqpB-3ffrA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		4 VAL A 180
LEU A 144
LEU A 365
LEU A 364
 None
 0.83A 1cqpA-3g7uA:
undetectable
1cqpB-3g7uA:
2.3		 1cqpA-3g7uA:
18.59
1cqpB-3g7uA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghj PUTATIVE INTEGRON
GENE CASSETTE
PROTEIN

(uncultured
bacterium) 		PF00903
(Glyoxalase) 		4 VAL A  72
VAL A  47
LEU A  84
LEU A  80
 None
 0.72A 1cqpA-3ghjA:
undetectable
1cqpB-3ghjA:
undetectable		 1cqpA-3ghjA:
19.67
1cqpB-3ghjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr6 PUTATIVE
SURFACE-ANCHORED
FIMBRIAL SUBUNIT

(Corynebacterium
diphtheriae) 		no annotation 4 VAL A 185
LEU A  91
VAL A 151
LEU A  99
 None
 0.81A 1cqpA-3hr6A:
undetectable
1cqpB-3hr6A:
undetectable		 1cqpA-3hr6A:
20.05
1cqpB-3hr6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 VAL 3 511
VAL 3 532
LEU 3 481
LEU 3 477
 None
 0.76A 1cqpA-3i9v3:
3.6
1cqpB-3i9v3:
3.3		 1cqpA-3i9v3:
13.17
1cqpB-3i9v3:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iby FERROUS IRON
TRANSPORT PROTEIN B

(Legionella
pneumophila) 		PF02421
(FeoB_N) 		4 VAL A 114
LEU A  17
LEU A  45
LEU A 161
 None
 0.72A 1cqpA-3ibyA:
3.3
1cqpB-3ibyA:
3.9		 1cqpA-3ibyA:
24.91
1cqpB-3ibyA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 VAL A 387
LEU A 613
VAL A 621
LEU A 362
 None
 0.73A 1cqpA-3j04A:
undetectable
1cqpB-3j04A:
undetectable		 1cqpA-3j04A:
11.10
1cqpB-3j04A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 VAL A 790
LEU A 697
LEU A 829
LEU A 832
 None
 0.86A 1cqpA-3j0aA:
4.4
1cqpB-3j0aA:
undetectable		 1cqpA-3j0aA:
13.10
1cqpB-3j0aA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 LEU F 280
VAL F 283
LEU F 117
LEU F  99
 None
 0.88A 1cqpA-3kfuF:
undetectable
1cqpB-3kfuF:
undetectable		 1cqpA-3kfuF:
15.00
1cqpB-3kfuF:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu8 AMINOTRANSFERASE
WBPE

(Pseudomonas
aeruginosa) 		PF01041
(DegT_DnrJ_EryC1) 		4 VAL A 286
LEU A 298
VAL A 294
LEU A 263
 None
 0.79A 1cqpA-3nu8A:
undetectable
1cqpB-3nu8A:
undetectable		 1cqpA-3nu8A:
19.83
1cqpB-3nu8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 VAL B 624
LEU B 617
VAL B 662
LEU B 502
 None
 0.81A 1cqpA-3pcoB:
undetectable
1cqpB-3pcoB:
undetectable		 1cqpA-3pcoB:
13.01
1cqpB-3pcoB:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		4 VAL A 291
VAL A 267
LEU A 319
LEU A  98
 None
 0.89A 1cqpA-3qkiA:
undetectable
1cqpB-3qkiA:
undetectable		 1cqpA-3qkiA:
15.49
1cqpB-3qkiA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 432
VAL A 434
LEU A 474
LEU A 450
 None
 0.81A 1cqpA-3rg1A:
undetectable
1cqpB-3rg1A:
undetectable		 1cqpA-3rg1A:
13.49
1cqpB-3rg1A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 VAL A 166
LEU A 207
LEU A 127
LEU A 128
 None
 0.72A 1cqpA-3sdqA:
undetectable
1cqpB-3sdqA:
undetectable		 1cqpA-3sdqA:
12.72
1cqpB-3sdqA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sns LIPOPROTEIN 34

(Escherichia
coli) 		PF06804
(Lipoprotein_18) 		4 VAL A 337
LEU A 259
TYR A 280
LEU A 326
 None
 0.86A 1cqpA-3snsA:
undetectable
1cqpB-3snsA:
undetectable		 1cqpA-3snsA:
17.78
1cqpB-3snsA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 5 VAL A 353
VAL A 294
TYR A 300
LEU A 330
LEU A 333
 None
 1.33A 1cqpA-3ssmA:
undetectable
1cqpB-3ssmA:
undetectable		 1cqpA-3ssmA:
17.53
1cqpB-3ssmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 VAL A 428
LEU A 514
LEU A 654
LEU A 653
 None
 0.67A 1cqpA-3t6gA:
undetectable
1cqpB-3t6gA:
undetectable		 1cqpA-3t6gA:
19.39
1cqpB-3t6gA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqf D-THREO-3-HYDROXYASP
ARTATE DEHYDRATASE

(Delftia sp.
HT23) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 VAL A 250
TYR A 177
LEU A 188
LEU A 185
 None
PLP  A 401 (-4.6A)
None
None
 0.77A 1cqpA-3wqfA:
undetectable
1cqpB-3wqfA:
undetectable		 1cqpA-3wqfA:
18.23
1cqpB-3wqfA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zoq URACIL-DNA
GLYCOSYLASE

(Bacillus
subtilis) 		PF03167
(UDG) 		4 VAL A 151
LEU A 120
VAL A  57
LEU A  13
 None
 0.80A 1cqpA-3zoqA:
undetectable
1cqpB-3zoqA:
undetectable		 1cqpA-3zoqA:
23.38
1cqpB-3zoqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae) 		PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T) 		4 VAL A 118
LEU A 106
LEU A 138
LEU A 136
 None
 0.77A 1cqpA-4ae0A:
undetectable
1cqpB-4ae0A:
undetectable		 1cqpA-4ae0A:
15.58
1cqpB-4ae0A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7k SAM-DEPENDENT
METHYLTRANSFERASES

(Streptomyces
davaonensis) 		PF00891
(Methyltransf_2) 		4 VAL A 208
LEU A 250
VAL A 253
LEU A 241
 None
 0.68A 1cqpA-4d7kA:
undetectable
1cqpB-4d7kA:
undetectable		 1cqpA-4d7kA:
19.77
1cqpB-4d7kA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 VAL A 322
LEU A 267
LEU A  41
LEU A  44
 None
 0.88A 1cqpA-4e8dA:
undetectable
1cqpB-4e8dA:
undetectable		 1cqpA-4e8dA:
15.91
1cqpB-4e8dA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 VAL D 265
VAL D 241
LEU D 292
LEU D 100
 None
 0.87A 1cqpA-4em6D:
undetectable
1cqpB-4em6D:
2.2		 1cqpA-4em6D:
15.90
1cqpB-4em6D:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id0 GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF

(Pseudomonas
fluorescens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 VAL A  28
TYR A  73
LEU A  18
LEU A  19
 None
 0.85A 1cqpA-4id0A:
undetectable
1cqpB-4id0A:
undetectable		 1cqpA-4id0A:
18.72
1cqpB-4id0A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		4 LEU A 390
VAL A 409
TYR A 247
LEU A 252
 None
 0.88A 1cqpA-4ihqA:
2.5
1cqpB-4ihqA:
2.6		 1cqpA-4ihqA:
16.80
1cqpB-4ihqA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LEU A 982
VAL A 986
LEU A 930
LEU A 933
 None
 0.67A 1cqpA-4j3bA:
undetectable
1cqpB-4j3bA:
undetectable		 1cqpA-4j3bA:
13.06
1cqpB-4j3bA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 VAL A 101
LEU A  38
VAL A  41
LEU A 224
 None
 0.67A 1cqpA-4jb7A:
undetectable
1cqpB-4jb7A:
2.5		 1cqpA-4jb7A:
20.85
1cqpB-4jb7A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 448
VAL A 462
TYR A 371
LEU A 323
 None
 0.88A 1cqpA-4jhvA:
undetectable
1cqpB-4jhvA:
undetectable		 1cqpA-4jhvA:
17.30
1cqpB-4jhvA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhu ECTOINE HYDROXYLASE

(Sphingopyxis
alaskensis) 		PF05721
(PhyH) 		4 VAL A 236
LEU A  61
VAL A  58
LEU A 111
 None
 0.79A 1cqpA-4mhuA:
undetectable
1cqpB-4mhuA:
undetectable		 1cqpA-4mhuA:
19.50
1cqpB-4mhuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 VAL A 417
LEU A 430
VAL A 460
LEU A 561
 None
 0.86A 1cqpA-4n2cA:
undetectable
1cqpB-4n2cA:
undetectable		 1cqpA-4n2cA:
14.22
1cqpB-4n2cA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 VAL A 649
LEU A 678
VAL A 699
LEU A 721
 None
 0.86A 1cqpA-4n3sA:
undetectable
1cqpB-4n3sA:
undetectable		 1cqpA-4n3sA:
18.14
1cqpB-4n3sA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 VAL A 488
LEU A 460
VAL A 483
LEU A 467
 None
 0.82A 1cqpA-4nk6A:
undetectable
1cqpB-4nk6A:
undetectable		 1cqpA-4nk6A:
15.35
1cqpB-4nk6A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		4 VAL A  62
LEU A 278
TYR A  42
LEU A 173
 None
 0.61A 1cqpA-4ovyA:
3.9
1cqpB-4ovyA:
3.9		 1cqpA-4ovyA:
22.04
1cqpB-4ovyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		4 LEU A 199
VAL A 198
LEU A 415
LEU A 414
 None
 0.80A 1cqpA-4pu5A:
undetectable
1cqpB-4pu5A:
undetectable		 1cqpA-4pu5A:
17.22
1cqpB-4pu5A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 VAL A 497
TYR A 774
LEU A 457
LEU A 456
 None
 0.75A 1cqpA-4rbnA:
undetectable
1cqpB-4rbnA:
undetectable		 1cqpA-4rbnA:
12.66
1cqpB-4rbnA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmz EIF5B

(Chaetomium
thermophilum) 		no annotation 4 VAL B 767
LEU B 796
VAL B 817
LEU B 839
 None
 0.87A 1cqpA-4tmzB:
undetectable
1cqpB-4tmzB:
3.2		 1cqpA-4tmzB:
18.93
1cqpB-4tmzB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 VAL A  68
LEU A 330
VAL A 309
LEU A 271
 None
 0.88A 1cqpA-4tz5A:
undetectable
1cqpB-4tz5A:
undetectable		 1cqpA-4tz5A:
15.72
1cqpB-4tz5A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNH

(Escherichia
coli) 		PF05845
(PhnH) 		4 VAL B  96
LEU B  85
LEU B  53
LEU B  52
 None
 0.86A 1cqpA-4xb6B:
undetectable
1cqpB-4xb6B:
undetectable		 1cqpA-4xb6B:
20.98
1cqpB-4xb6B:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		4 VAL A  29
TYR A  27
LEU A 205
LEU A 201
 None
 0.64A 1cqpA-4zhjA:
4.2
1cqpB-4zhjA:
3.1		 1cqpA-4zhjA:
9.19
1cqpB-4zhjA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		5 VAL A 114
LEU A 105
VAL A 371
TYR A 368
LEU A 363
 None
 1.30A 1cqpA-4zm6A:
6.5
1cqpB-4zm6A:
3.6		 1cqpA-4zm6A:
12.64
1cqpB-4zm6A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af3 VAPBC49

(Mycobacterium
tuberculosis) 		PF04255
(DUF433) 		4 LEU A 159
VAL A 155
LEU A  96
LEU A  99
 None
 0.83A 1cqpA-5af3A:
undetectable
1cqpB-5af3A:
undetectable		 1cqpA-5af3A:
20.24
1cqpB-5af3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		4 VAL A 569
VAL A 613
LEU A 533
LEU A 529
 None
 0.85A 1cqpA-5b48A:
undetectable
1cqpB-5b48A:
undetectable		 1cqpA-5b48A:
15.37
1cqpB-5b48A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens) 		PF04189
(Gcd10p) 		4 VAL B 399
LEU B 423
LEU B 385
LEU B 384
 None
 0.80A 1cqpA-5ccxB:
undetectable
1cqpB-5ccxB:
undetectable		 1cqpA-5ccxB:
17.72
1cqpB-5ccxB:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A 132
VAL A 233
TYR A 257
LYS A 287
LEU A 298
 None
 0.47A 1cqpA-5e6sA:
33.1
1cqpB-5e6sA:
32.9		 1cqpA-5e6sA:
100.00
1cqpB-5e6sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 VAL A  19
LEU A  40
VAL A  36
LEU A 125
 None
 0.83A 1cqpA-5hxaA:
4.2
1cqpB-5hxaA:
2.3		 1cqpA-5hxaA:
17.43
1cqpB-5hxaA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 VAL A  39
LEU A 123
VAL A 120
LEU A  71
 None
 0.84A 1cqpA-5i2hA:
2.7
1cqpB-5i2hA:
2.7		 1cqpA-5i2hA:
18.86
1cqpB-5i2hA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		4 VAL A 438
LEU A  26
VAL A  75
LEU A 471
 None
 0.87A 1cqpA-5j55A:
undetectable
1cqpB-5j55A:
undetectable		 1cqpA-5j55A:
18.86
1cqpB-5j55A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 175
LEU A  75
VAL A  71
LEU A  34
 None
 0.74A 1cqpA-5k6oA:
undetectable
1cqpB-5k6oA:
undetectable		 1cqpA-5k6oA:
10.77
1cqpB-5k6oA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		4 VAL A 157
LEU A 171
VAL A 144
LEU A 151
 None
 0.80A 1cqpA-5kreA:
4.0
1cqpB-5kreA:
4.0		 1cqpA-5kreA:
19.67
1cqpB-5kreA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 VAL A 367
LEU A 221
LEU A 441
LEU A 444
 None
 0.87A 1cqpA-5ktkA:
3.3
1cqpB-5ktkA:
3.4		 1cqpA-5ktkA:
15.90
1cqpB-5ktkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mek CYTOSOLIC
SULFOTRANSFERASE 18

(Arabidopsis
thaliana) 		PF00685
(Sulfotransfer_1) 		4 VAL A 173
LEU A 151
VAL A 128
LEU A 257
 None
 0.60A 1cqpA-5mekA:
undetectable
1cqpB-5mekA:
undetectable		 1cqpA-5mekA:
20.45
1cqpB-5mekA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 4 VAL A 907
VAL A 739
LEU A 928
LEU A 924
 None
 0.87A 1cqpA-5mwpA:
undetectable
1cqpB-5mwpA:
undetectable		 1cqpA-5mwpA:
16.57
1cqpB-5mwpA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		4 LEU A 125
VAL A 119
LEU A 430
LEU A 198
 None
 0.78A 1cqpA-5t81A:
undetectable
1cqpB-5t81A:
undetectable		 1cqpA-5t81A:
14.45
1cqpB-5t81A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		4 VAL A  11
LEU A  32
VAL A  28
LEU A 118
 None
 0.87A 1cqpA-5tvgA:
4.3
1cqpB-5tvgA:
3.7		 1cqpA-5tvgA:
19.20
1cqpB-5tvgA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		4 VAL A 206
LEU A 237
VAL A 220
LEU A 228
 None
 0.74A 1cqpA-5vc2A:
2.7
1cqpB-5vc2A:
2.6		 1cqpA-5vc2A:
18.10
1cqpB-5vc2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 4 VAL A 442
LEU A 481
VAL A 478
LEU A 422
 None
 0.69A 1cqpA-5vopA:
undetectable
1cqpB-5vopA:
undetectable		 1cqpA-5vopA:
21.39
1cqpB-5vopA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 4 VAL A 188
VAL A 110
LEU A 214
LEU A 219
 None
 0.89A 1cqpA-5wabA:
4.4
1cqpB-5wabA:
4.7		 1cqpA-5wabA:
19.39
1cqpB-5wabA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9g MAGNESIUM
TRANSPORTER MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF03448
(MgtE_N) 		4 VAL A 100
LEU A  61
LEU A 115
LEU A 111
 None
 0.87A 1cqpA-5x9gA:
undetectable
1cqpB-5x9gA:
undetectable		 1cqpA-5x9gA:
20.86
1cqpB-5x9gA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP

(Streptomyces
wadayamensis) 		no annotation 4 VAL A 372
LEU A 292
VAL A 298
LEU A 326
 None
 0.87A 1cqpA-6c9bA:
undetectable
1cqpB-6c9bA:
undetectable		 1cqpA-6c9bA:
16.47
1cqpB-6c9bA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckb -

(-) 		no annotation 5 LEU A 114
VAL A 215
TYR A 239
LYS A 269
LEU A 280
 None
 0.59A 1cqpA-6ckbA:
32.3
1cqpB-6ckbA:
32.2		 1cqpA-6ckbA:
undetectable
1cqpB-6ckbA:
undetectable