SIMILAR PATTERNS OF AMINO ACIDS FOR 1CEB_B_AMHB90

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0h MEIZOTHROMBIN

(Bos taurus) 		PF00051
(Kringle)
PF09396
(Thrombin_light) 		4 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.51A 1cebB-1a0hA:
8.9		 1cebB-1a0hA:
31.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i71 APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  54
TRP A  60
TYR A  62
ARG A  69
 None
None
SO4  A 300 (-4.7A)
SO4  A 300 (-3.8A)
 1.02A 1cebB-1i71A:
15.5		 1cebB-1i71A:
44.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kiv APOLIPOPROTEIN A

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 None
 0.55A 1cebB-1kivA:
15.5		 1cebB-1kivA:
54.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pkr PLASMINOGEN

(Homo sapiens) 		PF00051
(Kringle) 		6 ASP A  55
ASP A  57
TRP A  62
TYR A  64
ARG A  71
TYR A  72
 CL  A  91 ( 4.7A)
None
None
None
CL  A  90 (-3.6A)
None
 0.61A 1cebB-1pkrA:
17.7		 1cebB-1pkrA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF02358
(Trehalose_PPase) 		4 ASP A 183
ASP A   7
TYR A 146
ARG A 155
 MG  A 240 ( 4.5A)
MG  A 240 (-2.5A)
None
None
 1.25A 1cebB-1u02A:
undetectable		 1cebB-1u02A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 ASP A 185
ASP A 186
TYR A 223
TYR A 220
 None
 1.49A 1cebB-1ua7A:
undetectable		 1cebB-1ua7A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 ASP A 510
ASP A 157
TYR A 110
ARG A 111
 None
 1.14A 1cebB-1zsqA:
undetectable		 1cebB-1zsqA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyl HYPOTHETICAL PROTEIN
YIHE

(Escherichia
coli) 		PF01636
(APH) 		4 ASP A 220
ASP A 219
TRP A  62
ARG A 283
 None
 1.12A 1cebB-1zylA:
undetectable		 1cebB-1zylA:
11.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2doi ANGIOSTATIN

(Homo sapiens) 		no annotation 6 ASP X 137
ASP X 139
TRP X 144
TYR X 146
ARG X 153
TYR X 154
 None
 0.60A 1cebB-2doiX:
17.1		 1cebB-2doiX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hpp PROTHROMBIN

(Bos taurus) 		PF00051
(Kringle) 		4 ASP P 354
ASP P 356
TRP P 361
TYR P 363
 None
 0.83A 1cebB-2hppP:
10.4		 1cebB-2hppP:
36.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jer AGMATINE DEIMINASE

(Enterococcus
faecalis) 		PF04371
(PAD_porph) 		4 ASP A  96
TRP A 119
TYR A 127
ARG A  34
 AGT  A 357 ( 3.3A)
AGT  A 357 ( 3.9A)
None
None
 1.44A 1cebB-2jerA:
undetectable		 1cebB-2jerA:
10.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pk4 HUMAN PLASMINOGEN
KRINGLE 4

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
 0.53A 1cebB-2pk4A:
15.8		 1cebB-2pk4A:
51.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2por PORIN

(Rhodobacter
capsulatus) 		PF13609
(Porin_4) 		4 ASP A  93
ASP A  95
TYR A  87
TYR A 248
 CA  A 303 (-2.1A)
CA  A 303 (-2.2A)
None
None
 1.44A 1cebB-2porA:
undetectable		 1cebB-2porA:
13.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2spt PROTHROMBIN

(Bos taurus) 		PF00051
(Kringle)
PF00594
(Gla) 		4 ASP A 119
TRP A 126
TYR A 128
ARG A 135
 None
 0.78A 1cebB-2sptA:
16.8		 1cebB-2sptA:
37.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ASP A 483
TRP A 439
TYR A 469
ARG A 480
 None
None
None
PEG  A1777 (-3.0A)
 1.50A 1cebB-2wdaA:
undetectable		 1cebB-2wdaA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		4 ASP A1012
TYR A1032
ARG A 949
TYR A1033
 None
 1.36A 1cebB-2yn9A:
undetectable		 1cebB-2yn9A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 ASP A 511
ASP A 512
TYR A  38
ARG A  35
 None
None
None
DG3  A 576 (-3.6A)
 1.45A 1cebB-3auoA:
undetectable		 1cebB-3auoA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		4 ASP A 278
ASP A 279
TYR A 287
ARG A 290
 None
 1.43A 1cebB-3c0kA:
undetectable		 1cebB-3c0kA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6p PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle)
PF09396
(Thrombin_light) 		4 ASP L 223
ASP L 225
TRP L 230
TYR L 232
 None
 0.33A 1cebB-3e6pL:
10.5		 1cebB-3e6pL:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		4 ASP A  94
TRP A 125
TYR A 133
ARG A  32
 AGT  A 366 ( 3.0A)
AGT  A 366 (-3.9A)
None
None
 1.47A 1cebB-3h7kA:
undetectable		 1cebB-3h7kA:
12.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k65 PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.40A 1cebB-3k65A:
11.0		 1cebB-3k65A:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 ASP A 995
TYR A1015
ARG A 933
TYR A1016
 None
 1.25A 1cebB-3n23A:
undetectable		 1cebB-3n23A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.50A 1cebB-3nxpA:
undetectable		 1cebB-3nxpA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		4 ASP A 151
ASP A 169
TYR A 324
ARG A  74
 None
1N1  A1000 (-3.4A)
None
None
 1.32A 1cebB-3ohtA:
undetectable		 1cebB-3ohtA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9o DIGUANYLATE CYCLASE
DGCZ

(Escherichia
coli) 		no annotation 4 ASP A  65
ASP A  67
TYR A 120
TYR A 123
 None
 1.18A 1cebB-3t9oA:
undetectable		 1cebB-3t9oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ASP A 214
TYR A 283
ARG A 325
TYR A 278
 None
 1.38A 1cebB-3uggA:
undetectable		 1cebB-3uggA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 ASP A 454
TRP A 460
TYR A 490
ARG A 530
 None
 1.44A 1cebB-3va6A:
undetectable		 1cebB-3va6A:
7.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bvv APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  55
ASP A  57
TRP A  62
TYR A  64
 CPF  A1081 (-3.1A)
CPF  A1081 (-3.9A)
CPF  A1081 (-3.6A)
CPF  A1081 (-4.8A)
 0.47A 1cebB-4bvvA:
16.8		 1cebB-4bvvA:
53.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bvw APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  54
TRP A  60
TYR A  62
ARG A  69
 HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-4.6A)
HKY  A1080 (-3.5A)
 0.58A 1cebB-4bvwA:
15.9		 1cebB-4bvwA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		6 ASP A 137
ASP A 139
TRP A 144
TYR A 146
ARG A 153
TYR A 154
 None
 0.82A 1cebB-4duuA:
15.3		 1cebB-4duuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 ASP A 516
ASP A 518
TRP A 523
TYR A 525
TYR A 533
 None
 0.74A 1cebB-4duuA:
15.3		 1cebB-4duuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		4 ASP A 186
TRP A 260
TYR A 199
ARG A 202
 None
None
PEG  A 305 ( 4.5A)
None
 1.25A 1cebB-4eiuA:
undetectable		 1cebB-4eiuA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		4 ASP A 186
TRP A 260
TYR A 199
ARG A 202
 None
None
PEG  A 305 ( 4.5A)
None
 1.39A 1cebB-4eiuA:
undetectable		 1cebB-4eiuA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h54 DIGUANYLATE CYCLASE
YDEH

(Escherichia
coli) 		PF00990
(GGDEF) 		4 ASP A  65
ASP A  67
TYR A 120
TYR A 123
 None
 1.16A 1cebB-4h54A:
undetectable		 1cebB-4h54A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzh PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.36A 1cebB-4hzhA:
undetectable		 1cebB-4hzhA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 ASP A1002
TYR A1022
ARG A 940
TYR A1023
 None
 1.34A 1cebB-5aw4A:
undetectable		 1cebB-5aw4A:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 ASP B 472
ASP B 469
TYR B 548
ARG B 644
 None
 0.95A 1cebB-5dlqB:
undetectable		 1cebB-5dlqB:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 ASP A  55
TRP A 319
TYR A 326
ARG A 236
 None
None
212  A 404 (-4.3A)
212  A 404 (-3.1A)
 1.49A 1cebB-5dz2A:
undetectable		 1cebB-5dz2A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		4 ASP A 193
ASP A  32
TYR A  38
ARG A  35
 ZN  A 508 (-2.1A)
ZN  A 509 (-1.9A)
None
None
 1.30A 1cebB-5egeA:
undetectable		 1cebB-5egeA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		4 ASP X  31
ASP X  33
TYR X 192
ARG X 252
 None
ALY  X  35 ( 4.1A)
None
None
 1.28A 1cebB-5eztX:
undetectable		 1cebB-5eztX:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 ASP A  88
ASP A  90
TRP A  94
TYR A  96
 None
 0.57A 1cebB-5fwsA:
10.2		 1cebB-5fwsA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fww KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 ASP B  88
ASP B  90
TRP B  94
TYR B  96
 None
 0.76A 1cebB-5fwwB:
9.9		 1cebB-5fwwB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj2 HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF08214
(HAT_KAT11) 		4 ASP A1614
ASP A1616
TYR A1421
TYR A1424
 None
 1.44A 1cebB-5kj2A:
undetectable		 1cebB-5kj2A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		4 ASP A 252
TRP A 207
TYR A 222
ARG A 220
 None
 0.97A 1cebB-5kvaA:
undetectable		 1cebB-5kvaA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		4 ASP A1614
ASP A1616
TYR A1421
TYR A1424
 None
 1.46A 1cebB-5lkzA:
undetectable		 1cebB-5lkzA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
PHOTOSYSTEM II
PROTEIN D1

(Arabidopsis
thaliana) 		PF00124
(Photo_RC)
PF01716
(MSP) 		4 ASP A  59
ASP A  61
TYR O 236
ARG O 237
 None
 1.08A 1cebB-5mdxA:
undetectable		 1cebB-5mdxA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		4 ASP A1652
ASP A1654
TYR A1458
TYR A1461
 None
 1.40A 1cebB-5u7gA:
undetectable		 1cebB-5u7gA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 ASP A 199
ASP A  39
TYR A  45
ARG A  42
 ZN  A 502 (-2.3A)
ZN  A 501 (-2.0A)
None
None
 1.39A 1cebB-5udyA:
undetectable		 1cebB-5udyA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 ASP A 191
ASP A  36
TYR A  42
ARG A  39
 ZN  A 502 (-2.0A)
ZN  A 501 (-2.0A)
None
None
 1.35A 1cebB-5vemA:
undetectable		 1cebB-5vemA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		4 ASP A 191
ASP A  36
TYR A  42
ARG A  39
 ZN  A 501 (-2.0A)
ZN  A 502 ( 2.1A)
None
None
 1.37A 1cebB-5veoA:
undetectable		 1cebB-5veoA:
12.04