SIMILAR PATTERNS OF AMINO ACIDS FOR 1CEB_A_AMHA90_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0h MEIZOTHROMBIN

(Bos taurus) 		PF00051
(Kringle)
PF09396
(Thrombin_light) 		4 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.60A 1cebA-1a0hA:
8.9		 1cebA-1a0hA:
31.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 223
ASP A 264
ASP A 260
TYR A 221
 PTR  A 216 ( 2.9A)
None
None
None
 1.41A 1cebA-1gngA:
undetectable		 1cebA-1gngA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 ARG A 488
ASP A 376
ASP A 377
TYR A 420
 None
R03  A 800 ( 4.1A)
R03  A 800 ( 4.3A)
R03  A 800 ( 4.9A)
 1.25A 1cebA-1h39A:
undetectable		 1cebA-1h39A:
9.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i71 APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  54
TRP A  60
TYR A  62
ARG A  69
 None
None
SO4  A 300 (-4.7A)
SO4  A 300 (-3.8A)
 1.07A 1cebA-1i71A:
15.6		 1cebA-1i71A:
44.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kiv APOLIPOPROTEIN A

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 None
 0.76A 1cebA-1kivA:
15.7		 1cebA-1kivA:
54.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvg GUANYLATE KINASE

(Mus musculus) 		PF00625
(Guanylate_kin) 		4 ARG A  44
ASP A 103
TYR A  53
ARG A  41
 5GP  A1202 (-3.1A)
5GP  A1202 (-3.8A)
5GP  A1202 (-4.5A)
5GP  A1202 (-3.8A)
 1.37A 1cebA-1lvgA:
undetectable		 1cebA-1lvgA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		4 ASP A 738
ASP A 740
TRP A 805
TYR A 673
 None
 1.16A 1cebA-1no7A:
undetectable		 1cebA-1no7A:
7.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pkr PLASMINOGEN

(Homo sapiens) 		PF00051
(Kringle) 		6 ARG A  34
ASP A  55
TRP A  62
TYR A  64
ARG A  71
TYR A  72
 None
CL  A  91 ( 4.7A)
None
None
CL  A  90 (-3.6A)
None
 0.81A 1cebA-1pkrA:
18.0		 1cebA-1pkrA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pkr PLASMINOGEN

(Homo sapiens) 		PF00051
(Kringle) 		6 ASP A  55
ASP A  57
TRP A  62
TYR A  64
ARG A  71
TYR A  72
 CL  A  91 ( 4.7A)
None
None
None
CL  A  90 (-3.6A)
None
 0.63A 1cebA-1pkrA:
18.0		 1cebA-1pkrA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		4 ARG A 234
ASP A 177
ASP A 151
ARG A 232
 None
 1.44A 1cebA-1pxzA:
undetectable		 1cebA-1pxzA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo3 LY49A

(Mus musculus) 		PF00059
(Lectin_C)
PF08391
(Ly49) 		4 ASP C 179
ASP C 181
TYR C 151
TYR C 146
 None
 1.29A 1cebA-1qo3C:
undetectable		 1cebA-1qo3C:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkb PROTEIN AD-004

(Homo sapiens) 		PF13238
(AAA_18) 		4 ARG A  70
ASP A  63
ASP A  59
ARG A  87
 None
None
LI  A 303 ( 4.6A)
None
 1.49A 1cebA-1rkbA:
undetectable		 1cebA-1rkbA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuh HYPOTHETICAL PROTEIN
EGC068

(uncultured
bacterium) 		PF12680
(SnoaL_2) 		4 ARG A  77
ASP A 145
TRP A 144
TYR A  78
 None
 1.48A 1cebA-1tuhA:
undetectable		 1cebA-1tuhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ASP A 573
TRP A 519
TYR A 418
ARG A 421
 None
 1.29A 1cebA-1z68A:
undetectable		 1cebA-1z68A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 ASP A 510
ASP A 157
TYR A 110
ARG A 111
 None
 1.18A 1cebA-1zsqA:
undetectable		 1cebA-1zsqA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		4 ASP A 331
ASP A 330
TYR A 312
TYR A 325
 None
 1.44A 1cebA-2cxiA:
undetectable		 1cebA-2cxiA:
13.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2doi ANGIOSTATIN

(Homo sapiens) 		no annotation 6 ASP X 137
ASP X 139
TRP X 144
TYR X 146
ARG X 153
TYR X 154
 None
 0.59A 1cebA-2doiX:
17.1		 1cebA-2doiX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hpp PROTHROMBIN

(Bos taurus) 		PF00051
(Kringle) 		4 ASP P 354
ASP P 356
TRP P 361
TYR P 363
 None
 1.05A 1cebA-2hppP:
10.4		 1cebA-2hppP:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hpq PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP P 354
ASP P 356
TRP P 361
TYR P 363
 None
 0.80A 1cebA-2hpqP:
10.5		 1cebA-2hpqP:
35.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00483
(NTP_transferase) 		4 ARG A  25
ASP A 142
ASP A 143
TYR A 179
 None
MG  A 325 ( 2.6A)
UPG  A 326 (-3.5A)
UPG  A 326 (-4.6A)
 0.88A 1cebA-2pa4A:
undetectable		 1cebA-2pa4A:
13.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pk4 HUMAN PLASMINOGEN
KRINGLE 4

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.6A)
 0.57A 1cebA-2pk4A:
15.9		 1cebA-2pk4A:
51.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 ARG A 252
ASP A  82
TRP A 117
ARG A 180
 None
 1.47A 1cebA-2q7sA:
undetectable		 1cebA-2q7sA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb7 PEPTIDASE,
M20/M25/M40 FAMILY

(Desulfovibrio
alaskensis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASP A 137
ASP A  74
TYR A 312
ARG A 311
 None
 1.33A 1cebA-2rb7A:
undetectable		 1cebA-2rb7A:
12.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2spt PROTHROMBIN

(Bos taurus) 		PF00051
(Kringle)
PF00594
(Gla) 		4 ASP A 119
TRP A 126
TYR A 128
ARG A 135
 None
 0.59A 1cebA-2sptA:
16.5		 1cebA-2sptA:
37.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc2 INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF13517
(VCBS) 		4 ARG A 400
ASP A 373
ASP A 365
TYR A 371
 None
CA  A2006 (-2.4A)
CA  A2006 (-3.4A)
None
 1.29A 1cebA-2vc2A:
undetectable		 1cebA-2vc2A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ASP A 483
TRP A 439
TYR A 469
ARG A 480
 None
None
None
PEG  A1777 (-3.0A)
 1.45A 1cebA-2wdaA:
undetectable		 1cebA-2wdaA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ASP A 546
TRP A 547
TYR A 169
ARG A 563
 None
 1.49A 1cebA-2ya2A:
undetectable		 1cebA-2ya2A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		4 ASP A1012
TYR A1032
ARG A 949
TYR A1033
 None
 1.35A 1cebA-2yn9A:
undetectable		 1cebA-2yn9A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 ASP A 511
ASP A 512
TYR A  38
ARG A  35
 None
None
None
DG3  A 576 (-3.6A)
 1.49A 1cebA-3auoA:
undetectable		 1cebA-3auoA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ASP A 794
ASP A 797
TYR A 898
ARG A 901
 None
 1.20A 1cebA-3bgaA:
undetectable		 1cebA-3bgaA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		4 ASP A 278
ASP A 279
TYR A 287
ARG A 290
 None
 1.47A 1cebA-3c0kA:
undetectable		 1cebA-3c0kA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6p PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle)
PF09396
(Thrombin_light) 		4 ASP L 223
ASP L 225
TRP L 230
TYR L 232
 None
 0.46A 1cebA-3e6pL:
10.5		 1cebA-3e6pL:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k65 PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.38A 1cebA-3k65A:
11.0		 1cebA-3k65A:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lax PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
vulgatus) 		PF14535
(AMP-binding_C_2) 		4 ASP A 327
ASP A 328
TYR A 356
ARG A 424
 None
 1.45A 1cebA-3laxA:
undetectable		 1cebA-3laxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A 396
ASP A 267
TYR A 393
TYR A 292
 ATP  A 600 (-4.2A)
ATP  A 600 (-4.1A)
ATP  A 600 ( 3.7A)
None
 1.20A 1cebA-3lgxA:
undetectable		 1cebA-3lgxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 ASP A 995
TYR A1015
ARG A 933
TYR A1016
 None
 1.26A 1cebA-3n23A:
undetectable		 1cebA-3n23A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsw EXCRETORY-SECRETORY
PROTEIN 2

(Ancylostoma
ceylanicum) 		no annotation 4 ASP A  90
TYR A  42
ARG A  40
TYR A  23
 None
 1.07A 1cebA-3nswA:
undetectable		 1cebA-3nswA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.48A 1cebA-3nxpA:
undetectable		 1cebA-3nxpA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 ASP B 113
TRP B 116
TYR B 404
ARG A 156
 None
 1.34A 1cebA-3ojyB:
undetectable		 1cebA-3ojyB:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		4 ASP A  91
ASP A  88
TYR A  75
TYR A  78
 None
 1.40A 1cebA-3pmmA:
undetectable		 1cebA-3pmmA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ARG A 454
ASP A 404
ASP A 405
ARG A 365
 None
 1.48A 1cebA-3s9vA:
undetectable		 1cebA-3s9vA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 ARG A 429
ASP A 359
TRP A 365
TYR A 388
 None
 1.41A 1cebA-3va6A:
undetectable		 1cebA-3va6A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 ARG A1729
ASP A1722
ASP A1724
TYR A1698
 None
None
SO4  A2807 ( 2.9A)
None
 1.24A 1cebA-4aygA:
undetectable		 1cebA-4aygA:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 ARG A 803
ASP A1128
ASP A1151
TYR A 807
 None
None
C  R   9 ( 2.8A)
None
 1.39A 1cebA-4bocA:
undetectable		 1cebA-4bocA:
7.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bvv APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  55
ASP A  57
TRP A  62
TYR A  64
 CPF  A1081 (-3.1A)
CPF  A1081 (-3.9A)
CPF  A1081 (-3.6A)
CPF  A1081 (-4.8A)
 0.40A 1cebA-4bvvA:
16.7		 1cebA-4bvvA:
53.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bvw APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  54
TRP A  60
TYR A  62
ARG A  69
 HKY  A1080 (-3.0A)
HKY  A1080 (-3.6A)
HKY  A1080 (-4.6A)
HKY  A1080 (-3.5A)
 0.64A 1cebA-4bvwA:
16.1		 1cebA-4bvwA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		6 ASP A 137
ASP A 139
TRP A 144
TYR A 146
ARG A 153
TYR A 154
 None
 0.83A 1cebA-4duuA:
15.1		 1cebA-4duuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		4 ASP A 516
ASP A 518
TRP A 523
TYR A 525
 None
 0.78A 1cebA-4duuA:
15.1		 1cebA-4duuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		4 ASP A 516
TRP A 523
TYR A 525
TYR A 533
 None
 0.64A 1cebA-4duuA:
15.1		 1cebA-4duuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		4 ARG A 270
ASP A 289
TYR A 371
TYR A 375
 None
 1.47A 1cebA-4dweA:
undetectable		 1cebA-4dweA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		4 ASP A 186
TRP A 260
TYR A 199
ARG A 202
 None
None
PEG  A 305 ( 4.5A)
None
 1.11A 1cebA-4eiuA:
undetectable		 1cebA-4eiuA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzh PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.61A 1cebA-4hzhA:
undetectable		 1cebA-4hzhA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Sanguibacter
keddieii) 		PF13377
(Peripla_BP_3) 		4 ASP A 221
ASP A 220
TYR A 205
ARG A 209
 None
 1.47A 1cebA-4kmrA:
undetectable		 1cebA-4kmrA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2

(Homo sapiens) 		no annotation 4 ARG A 262
ASP A 309
ASP A 321
TYR A 250
 0EJ  A 402 (-3.0A)
MG  A 404 ( 2.9A)
MG  A 403 (-2.0A)
None
 1.11A 1cebA-4nzmA:
undetectable		 1cebA-4nzmA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus) 		PF02191
(OLF) 		4 ARG A 376
ASP A 330
ASP A 275
ARG A 324
 None
TRS  A 602 (-2.7A)
TRS  A 602 (-2.7A)
None
 1.39A 1cebA-4rmlA:
undetectable		 1cebA-4rmlA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ady GTPASE HFLX

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		4 ASP 6 288
ASP 6 285
ARG 6 257
TYR 6 205
 None
 1.48A 1cebA-5ady6:
undetectable		 1cebA-5ady6:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 ASP B 472
ASP B 469
TYR B 548
ARG B 644
 None
 1.08A 1cebA-5dlqB:
undetectable		 1cebA-5dlqB:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		4 ASP A 193
ASP A  32
TYR A  38
ARG A  35
 ZN  A 508 (-2.1A)
ZN  A 509 (-1.9A)
None
None
 1.32A 1cebA-5egeA:
undetectable		 1cebA-5egeA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 ASP A  88
ASP A  90
TRP A  94
TYR A  96
 None
 0.64A 1cebA-5fwsA:
10.2		 1cebA-5fwsA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fww KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 ASP B  88
ASP B  90
TRP B  94
TYR B  96
 None
 0.65A 1cebA-5fwwB:
9.8		 1cebA-5fwwB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 ASP A 305
ASP A 147
TYR A 153
ARG A 150
 ZN  A 901 (-2.2A)
ZN  A 902 (-1.8A)
None
None
 1.40A 1cebA-5gz4A:
undetectable		 1cebA-5gz4A:
8.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpg PLASMINOGEN

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  57
TRP A  62
TYR A  64
TYR A  72
 None
 0.72A 1cebA-5hpgA:
16.9		 1cebA-5hpgA:
54.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		4 ASP A 252
TRP A 207
TYR A 222
ARG A 220
 None
 0.92A 1cebA-5kvaA:
undetectable		 1cebA-5kvaA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
PHOTOSYSTEM II
PROTEIN D1

(Arabidopsis
thaliana) 		PF00124
(Photo_RC)
PF01716
(MSP) 		4 ASP A  59
ASP A  61
TYR O 236
ARG O 237
 None
 1.08A 1cebA-5mdxA:
undetectable		 1cebA-5mdxA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		4 ASP A1652
ASP A1654
TYR A1458
TYR A1461
 None
 1.47A 1cebA-5u7gA:
undetectable		 1cebA-5u7gA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 ASP A 199
ASP A  39
TYR A  45
ARG A  42
 ZN  A 502 (-2.3A)
ZN  A 501 (-2.0A)
None
None
 1.45A 1cebA-5udyA:
undetectable		 1cebA-5udyA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 ASP A 191
ASP A  36
TYR A  42
ARG A  39
 ZN  A 502 (-2.0A)
ZN  A 501 (-2.0A)
None
None
 1.40A 1cebA-5vemA:
undetectable		 1cebA-5vemA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		4 ASP A 191
ASP A  36
TYR A  42
ARG A  39
 ZN  A 501 (-2.0A)
ZN  A 502 ( 2.1A)
None
None
 1.41A 1cebA-5veoA:
undetectable		 1cebA-5veoA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 ARG A 403
ASP A 397
ASP A 393
TYR A 186
 None
 1.46A 1cebA-5w3fA:
undetectable		 1cebA-5w3fA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wde KINESIN-LIKE PROTEIN
KIFC3

(Homo sapiens) 		PF00225
(Kinesin) 		4 ARG A 665
ASP A 659
ASP A 565
TRP A 566
 None
 1.36A 1cebA-5wdeA:
undetectable		 1cebA-5wdeA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnf PHOSPHOETHANOLAMINE
TRANSFERASE

(Moraxella sp.
HMSC061H09) 		no annotation 4 ARG A 436
ASP A 438
ASP A 439
TYR A 395
 SO4  A 603 (-2.9A)
None
None
None
 1.47A 1cebA-6bnfA:
undetectable		 1cebA-6bnfA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 4 ASP A 326
ASP A 168
TYR A 174
ARG A 171
 ZN  A1003 ( 2.1A)
ZN  A1002 (-2.0A)
None
None
 1.47A 1cebA-6f2tA:
undetectable		 1cebA-6f2tA:
undetectable