SIMILAR PATTERNS OF AMINO ACIDS FOR 1CBR_A_REAA200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhd UTROPHIN

(Homo sapiens) 		PF00307
(CH) 		5 ALA A 184
ALA A 187
THR A 163
VAL A 160
LEU A 196
 None
 1.27A 1cbrA-1bhdA:
undetectable		 1cbrA-1bhdA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans) 		PF00463
(ICL) 		5 ALA A 192
PRO A 164
THR A  93
VAL A 127
LEU A  63
 None
 1.24A 1cbrA-1dquA:
undetectable		 1cbrA-1dquA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		5 LEU A 499
ALA A 524
PRO A 176
THR A 173
TYR A 187
 None
 1.08A 1cbrA-1e8tA:
undetectable		 1cbrA-1e8tA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		5 LEU A  36
ALA A  34
PRO A 225
ARG A  31
LEU A 242
 None
HEM  A 350 (-3.5A)
None
HEM  A 350 (-3.9A)
None
 1.26A 1cbrA-1fhfA:
undetectable		 1cbrA-1fhfA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		5 PHE A 213
LEU A 200
ALA A 198
THR A 225
THR A 223
 None
 1.15A 1cbrA-1fmlA:
undetectable		 1cbrA-1fmlA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 LEU A  68
ALA A  67
ALA A  92
PRO A 117
THR A  44
 None
 1.24A 1cbrA-1i7oA:
undetectable		 1cbrA-1i7oA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 LEU A 251
ALA A 227
ALA A 392
THR A 303
LEU A 418
 None
 1.23A 1cbrA-1i7oA:
undetectable		 1cbrA-1i7oA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 PHE A 329
LEU A 380
ALA A 384
ALA A 388
LEU A 306
 None
 1.27A 1cbrA-1iidA:
undetectable		 1cbrA-1iidA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
horikoshii) 		PF01470
(Peptidase_C15) 		5 ALA A 110
ALA A 159
PRO A 156
THR A 149
LEU A  49
 None
 1.15A 1cbrA-1iu8A:
undetectable		 1cbrA-1iu8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgu ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H  45
THR H 110
THR H 108
LEU H 170
TYR H 175
 None
 1.27A 1cbrA-1jguH:
undetectable		 1cbrA-1jguH:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 PHE A 183
ALA A 300
ALA A 277
VAL A 248
LEU A 166
 None
 1.24A 1cbrA-1lamA:
undetectable		 1cbrA-1lamA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 LEU A 137
ALA A  89
ALA A  51
THR A 402
TYR A 520
 None
 1.12A 1cbrA-1m53A:
undetectable		 1cbrA-1m53A:
12.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  16
PRO A  38
THR A  53
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.80A 1cbrA-1pmpA:
19.4		 1cbrA-1pmpA:
40.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A   7
ALA A  10
ALA A  13
ARG A  12
ARG A 274
 None
 1.28A 1cbrA-1qgdA:
undetectable		 1cbrA-1qgdA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl8 GLUCONATE
5-DEHYDROGENASE

(Thermotoga
maritima) 		PF13561
(adh_short_C2) 		5 LEU A 226
ALA A 230
ALA A 234
THR A  90
VAL A  92
 None
 1.12A 1cbrA-1vl8A:
undetectable		 1cbrA-1vl8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ALA A 593
ALA A 649
PRO A 682
LEU A  92
TYR A  88
 GOL  A 750 ( 4.8A)
None
None
None
None
 1.21A 1cbrA-1yr2A:
undetectable		 1cbrA-1yr2A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		5 LEU A  17
ALA A   5
ALA A 282
VAL A  59
ARG A  58
 None
 1.24A 1cbrA-2aa4A:
undetectable		 1cbrA-2aa4A:
17.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		6 LEU A  28
ALA A  32
ALA A  35
THR A  54
THR A  56
ARG A  59
 A80  A 201 ( 4.0A)
A80  A 201 ( 4.1A)
A80  A 201 ( 4.1A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
A80  A 201 (-4.8A)
 1.37A 1cbrA-2cbrA:
27.2		 1cbrA-2cbrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		12 PHE A  15
LEU A  28
ALA A  32
ALA A  36
PRO A  39
THR A  54
THR A  56
VAL A  58
ARG A  59
LEU A 120
ARG A 131
TYR A 133
 None
A80  A 201 ( 4.0A)
A80  A 201 ( 4.1A)
A80  A 201 ( 4.0A)
A80  A 201 ( 4.9A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
None
A80  A 201 (-4.8A)
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 0.43A 1cbrA-2cbrA:
27.2		 1cbrA-2cbrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		5 PHE A 613
LEU A 652
ALA A 650
ALA A 576
LEU A 550
 None
 1.16A 1cbrA-2cgeA:
undetectable		 1cbrA-2cgeA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 PHE A 562
LEU A 556
ALA A 558
ALA A 561
PRO A 440
 None
 1.25A 1cbrA-2d0vA:
undetectable		 1cbrA-2d0vA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE

(Azoarcus) 		PF13561
(adh_short_C2) 		5 PHE A  27
LEU A 220
ALA A 224
ALA A 228
LEU A   9
 None
 1.00A 1cbrA-2ewmA:
undetectable		 1cbrA-2ewmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF02909
(TetR_C) 		5 ALA A 174
ALA A 173
THR A 164
THR A 169
ARG A 170
 None
None
ACY  A 302 (-3.5A)
None
None
 1.27A 1cbrA-2g7gA:
undetectable		 1cbrA-2g7gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o62 HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		PF12204
(DUF3598) 		5 PHE A  97
LEU A 239
ALA A 236
ARG A 247
LEU A 261
 None
 1.25A 1cbrA-2o62A:
8.3		 1cbrA-2o62A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 PHE A 152
LEU A 101
ALA A 105
ALA A  80
ARG A  85
 None
None
None
ATP  A 281 (-3.6A)
ATP  A 281 (-4.2A)
 1.22A 1cbrA-2ogxA:
undetectable		 1cbrA-2ogxA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 ALA A 267
ALA A 372
THR A 376
LEU A 413
TYR A 418
 None
 1.25A 1cbrA-3b40A:
undetectable		 1cbrA-3b40A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 326
ALA A 296
ALA A 367
LEU A 261
TYR A 265
 None
 1.20A 1cbrA-3d1jA:
undetectable		 1cbrA-3d1jA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		5 LEU X 282
ALA X 280
ALA X 278
VAL X 207
LEU X 272
 C8E  X 454 ( 4.9A)
C8E  X 454 ( 3.9A)
None
None
C8E  X 453 ( 4.8A)
 1.25A 1cbrA-3dwoX:
2.8		 1cbrA-3dwoX:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1

(Mycobacterium
tuberculosis) 		PF00464
(SHMT) 		5 LEU A 236
ALA A  98
VAL A 251
LEU A 113
TYR A 137
 None
 1.18A 1cbrA-3h7fA:
undetectable		 1cbrA-3h7fA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7o GROUP 3 ALLERGEN
SMIPP-S YV6023A04

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 PHE A 212
LEU A 126
ALA A 172
PRO A 209
TYR A 160
 None
 1.17A 1cbrA-3h7oA:
undetectable		 1cbrA-3h7oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 PHE A 214
LEU A 121
ALA A 172
PRO A 211
TYR A 156
 None
 1.21A 1cbrA-3h7tA:
undetectable		 1cbrA-3h7tA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 PHE A 145
ALA A 217
ALA A 218
THR A 225
ARG A 224
 None
 1.13A 1cbrA-3i4gA:
undetectable		 1cbrA-3i4gA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1

(Homo sapiens) 		PF01369
(Sec7) 		5 PHE A 777
ALA A 805
ALA A 828
LEU A 870
TYR A 852
 None
 1.14A 1cbrA-3ltlA:
undetectable		 1cbrA-3ltlA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		5 PHE C 271
LEU C 310
ALA C 263
ALA C 267
VAL C 294
 None
 1.25A 1cbrA-3mc6C:
undetectable		 1cbrA-3mc6C:
14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  37
PRO A  39
THR A  54
ARG A 127
TYR A 129
 SO4  A 903 (-3.6A)
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 1.25A 1cbrA-3nr3A:
19.0		 1cbrA-3nr3A:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.86A 1cbrA-3nr3A:
19.0		 1cbrA-3nr3A:
36.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		5 LEU A  70
ALA A 101
PRO A  29
THR A  35
THR A  31
 None
 1.25A 1cbrA-3o82A:
undetectable		 1cbrA-3o82A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		5 PHE A 269
LEU A 221
ALA A 225
VAL A 232
LEU A   3
 None
 1.01A 1cbrA-3pnuA:
undetectable		 1cbrA-3pnuA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Pseudomonas
aeruginosa) 		PF03702
(AnmK) 		5 LEU A 333
ALA A 334
ALA A  90
THR A 120
LEU A  78
 None
 1.22A 1cbrA-3qbwA:
undetectable		 1cbrA-3qbwA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qef BETA-XYLOSIDASE/ALPH
A-L-ARABINFURANOSIDA
SE, GLY43N

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		5 LEU A  73
ALA A  55
ALA A  41
THR A 265
VAL A 297
 None
None
None
AHR  A 338 ( 4.8A)
None
 1.23A 1cbrA-3qefA:
undetectable		 1cbrA-3qefA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 PHE A 165
THR A 111
VAL A 101
ARG A 119
LEU A 159
 None
 1.21A 1cbrA-3qxzA:
undetectable		 1cbrA-3qxzA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r97 MALONYL COA-ACP
TRANSACYLASE

(Xanthomonas
oryzae) 		PF00698
(Acyl_transf_1) 		5 PHE A  35
LEU A  78
ALA A  74
ALA A  70
LEU A  49
 None
 1.26A 1cbrA-3r97A:
undetectable		 1cbrA-3r97A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r97 MALONYL COA-ACP
TRANSACYLASE

(Xanthomonas
oryzae) 		PF00698
(Acyl_transf_1) 		5 PHE A  35
LEU A  78
ALA A  74
ALA A  70
LEU A  58
 None
 1.02A 1cbrA-3r97A:
undetectable		 1cbrA-3r97A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 ALA A 300
ALA A 303
PRO A 306
VAL A 474
ARG A 301
 None
 1.12A 1cbrA-3slkA:
undetectable		 1cbrA-3slkA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1e HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		5 LEU A 498
ALA A 523
PRO A 176
THR A 173
TYR A 186
 None
 1.14A 1cbrA-3t1eA:
undetectable		 1cbrA-3t1eA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Streptomyces
avermitilis) 		PF00215
(OMPdecase) 		5 LEU A 262
ALA A 266
ALA A 270
PRO A  19
VAL A  22
 None
 1.21A 1cbrA-3v75A:
undetectable		 1cbrA-3v75A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 PHE A 205
LEU A 292
ALA A 288
ALA A 284
LEU A 241
 None
 1.12A 1cbrA-3vexA:
undetectable		 1cbrA-3vexA:
12.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
PRO A  38
THR A  53
LEU A 115
ARG A 126
TYR A 128
 2AN  A 201 ( 4.9A)
2AN  A 201 ( 4.3A)
2AN  A 201 ( 4.0A)
None
2AN  A 201 ( 4.9A)
None
 0.70A 1cbrA-3wbgA:
19.3		 1cbrA-3wbgA:
39.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwh (R)-AMINE
TRANSAMINASE

(Arthrobacter
sp. KNK168) 		PF01063
(Aminotran_4) 		5 LEU A 213
ALA A 220
ALA A 242
PRO A 244
VAL A 227
 None
 1.26A 1cbrA-3wwhA:
undetectable		 1cbrA-3wwhA:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
 0.85A 1cbrA-4a60A:
17.9		 1cbrA-4a60A:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9w MONOOXYGENASE

(Stenotrophomonas
maltophilia) 		PF13738
(Pyr_redox_3) 		5 ALA A 343
ALA A 340
PRO A  61
LEU A  91
TYR A  85
 None
 1.23A 1cbrA-4a9wA:
undetectable		 1cbrA-4a9wA:
16.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
ALA A  36
THR A  56
ARG A 129
TYR A 131
 None
 0.88A 1cbrA-4aznA:
18.7		 1cbrA-4aznA:
34.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
LEU A  32
ALA A  36
ARG A 129
TYR A 131
 None
 0.73A 1cbrA-4aznA:
18.7		 1cbrA-4aznA:
34.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
THR A  56
VAL A  60
ARG A 129
TYR A 131
 None
A9M  A1136 ( 4.3A)
A9M  A1136 (-4.8A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
 0.89A 1cbrA-4azpA:
19.5		 1cbrA-4azpA:
33.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg0 COMPLEMENT
REGULATOR-ACQUIRING
SURFACE PROTEIN 2
(CRASP-2 (CRASP-2)

(Borreliella
burgdorferi) 		no annotation 5 PHE A 200
ALA A 167
ALA A 156
VAL A 126
LEU A 207
 None
 1.23A 1cbrA-4bg0A:
undetectable		 1cbrA-4bg0A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		5 PHE A 376
LEU A 388
ALA A 359
ALA A 315
THR A 350
 None
 1.13A 1cbrA-4c2lA:
undetectable		 1cbrA-4c2lA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  29
ALA A  33
ALA A  37
VAL A 200
LEU A 259
 None
 1.13A 1cbrA-4e1lA:
undetectable		 1cbrA-4e1lA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans) 		PF00128
(Alpha-amylase) 		5 LEU A 387
ALA A  37
THR A  86
ARG A 395
LEU A 305
 None
 1.26A 1cbrA-4e2oA:
undetectable		 1cbrA-4e2oA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B

(Anaplasma
phagocytophilum) 		PF02502
(LacAB_rpiB) 		5 LEU A  86
ALA A  85
ALA A 102
THR A 127
LEU A 130
 None
 1.08A 1cbrA-4em8A:
undetectable		 1cbrA-4em8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 LEU A 228
ALA A 226
ALA A 248
THR A 245
VAL A 219
 None
 1.24A 1cbrA-4eyoA:
undetectable		 1cbrA-4eyoA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN

(Anaerococcus
prevotii) 		PF12710
(HAD) 		5 PHE A  42
ALA A  40
PRO A 311
THR A 331
LEU A 325
 None
 0.94A 1cbrA-4gxtA:
undetectable		 1cbrA-4gxtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU C 119
ALA C 117
THR C 378
VAL C  40
LEU C 382
 None
 1.26A 1cbrA-4gypC:
undetectable		 1cbrA-4gypC:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 242
ALA A 246
ALA A 251
THR A 269
VAL A 164
 None
 1.26A 1cbrA-4hacA:
undetectable		 1cbrA-4hacA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hx6 OXIDOREDUCTASE

(Streptomyces
globisporus) 		PF01613
(Flavin_Reduct) 		5 LEU A 130
ALA A  80
ALA A 120
PRO A  41
VAL A  34
 None
 1.08A 1cbrA-4hx6A:
undetectable		 1cbrA-4hx6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 PHE A 333
ALA A 342
ALA A 346
ARG A 437
TYR A 286
 None
 1.20A 1cbrA-4jclA:
undetectable		 1cbrA-4jclA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 LEU A 637
ALA A 372
THR A 616
VAL A 623
LEU A 549
 None
 1.07A 1cbrA-4k6mA:
undetectable		 1cbrA-4k6mA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Sanguibacter
keddieii) 		PF13377
(Peripla_BP_3) 		5 PHE A 253
LEU A 203
ALA A 172
ALA A 175
LEU A 296
 None
 1.20A 1cbrA-4kmrA:
undetectable		 1cbrA-4kmrA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 476
ALA A  62
THR A 486
VAL A 482
LEU A 328
 None
 1.10A 1cbrA-4l7tA:
undetectable		 1cbrA-4l7tA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN

(Burkholderia
cenocepacia) 		PF03328
(HpcH_HpaI) 		5 LEU A  84
ALA A  88
ALA A  93
VAL A  57
LEU A   8
 None
 0.91A 1cbrA-4mf4A:
undetectable		 1cbrA-4mf4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic PROBABLE PROTEIN
PHOSPHATASE 2C 6

(Oryza sativa) 		PF00481
(PP2C) 		5 PHE B 172
LEU B 196
ALA B 198
LEU B 220
TYR B 204
 None
 1.02A 1cbrA-4oicB:
undetectable		 1cbrA-4oicB:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 PHE B 583
LEU B 577
ALA B 579
ALA B 582
PRO B 467
 None
 1.26A 1cbrA-4tqoB:
undetectable		 1cbrA-4tqoB:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		5 PHE A 317
LEU A  89
ALA A 325
VAL A 338
ARG A 327
 None
 1.13A 1cbrA-4u9cA:
undetectable		 1cbrA-4u9cA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 LEU A 252
ALA A 256
ALA A 260
THR A 231
TYR A  51
 None
None
None
NA  A 702 ( 3.3A)
None
 0.97A 1cbrA-4us4A:
undetectable		 1cbrA-4us4A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 PHE A 288
LEU A 296
ALA A 337
ALA A 333
TYR A 326
 None
 1.17A 1cbrA-4xwhA:
undetectable		 1cbrA-4xwhA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ALA A 575
PRO A 525
THR A 527
LEU A 516
TYR A 518
 None
 1.27A 1cbrA-4z64A:
undetectable		 1cbrA-4z64A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 LEU A 898
ALA A 786
PRO A 799
THR A 832
THR A 835
 None
 1.24A 1cbrA-4zhjA:
undetectable		 1cbrA-4zhjA:
7.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PRO A  38
THR A  53
LEU A 115
ARG A 126
TYR A 128
 PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.2A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.67A 1cbrA-5b29A:
19.3		 1cbrA-5b29A:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3v BILIVERDIN REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 PHE B 189
ALA B 153
ALA B 231
ARG B 154
LEU B 179
 None
 1.24A 1cbrA-5b3vB:
undetectable		 1cbrA-5b3vB:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 PHE A  17
PRO A  39
THR A  54
THR A  57
TYR A 129
 None
 0.94A 1cbrA-5bvqA:
18.4		 1cbrA-5bvqA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 ALA A  39
PRO A  41
THR A  56
ARG A 130
TYR A 132
 PAM  A 201 (-3.3A)
PAM  A 201 ( 4.8A)
None
PAM  A 201 ( 4.6A)
None
 1.09A 1cbrA-5bvtA:
18.9		 1cbrA-5bvtA:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 PHE A  19
PRO A  41
THR A  56
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 4.8A)
None
PAM  A 201 ( 4.6A)
None
 0.73A 1cbrA-5bvtA:
18.9		 1cbrA-5bvtA:
38.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		5 LEU A 323
ALA A 327
THR A 312
LEU A  18
ARG A  21
 None
 1.23A 1cbrA-5dxxA:
undetectable		 1cbrA-5dxxA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae) 		PF00463
(ICL) 		5 ALA A 201
PRO A 173
THR A 102
VAL A 136
LEU A  72
 None
 1.22A 1cbrA-5e9gA:
undetectable		 1cbrA-5e9gA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9h ISOCITRATE LYASE

(Fusarium
graminearum) 		PF00463
(ICL) 		5 ALA A 201
PRO A 173
THR A 102
VAL A 136
LEU A  72
 None
 1.23A 1cbrA-5e9hA:
undetectable		 1cbrA-5e9hA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evm FUSION GLYCOPROTEIN
F0

(Nipah
henipavirus) 		PF00523
(Fusion_gly) 		5 LEU A 147
PRO A  63
THR A 173
LEU A  83
TYR A  79
 None
 1.26A 1cbrA-5evmA:
undetectable		 1cbrA-5evmA:
13.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		5 PHE A  16
PRO A  38
THR A  53
ARG A 125
TYR A 127
 None
 0.80A 1cbrA-5gkbA:
18.0		 1cbrA-5gkbA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  19
PRO A  41
THR A  56
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
65X  A 203 (-4.4A)
65X  A 203 (-3.0A)
65X  A 203 (-3.9A)
None
 0.72A 1cbrA-5hz5A:
19.0		 1cbrA-5hz5A:
37.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 569
ALA A 396
PRO A 588
LEU A 405
TYR A 649
 None
 1.26A 1cbrA-5ju6A:
undetectable		 1cbrA-5ju6A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 PHE A 370
ALA A 327
ALA A 353
THR A 120
ARG A 325
 None
 1.23A 1cbrA-5k8fA:
undetectable		 1cbrA-5k8fA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		5 PHE A 212
LEU A 600
ALA A 602
ALA A 569
THR A 362
 None
 1.01A 1cbrA-5lc8A:
undetectable		 1cbrA-5lc8A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D

(Methanothermococcus
thermolithotrophicus) 		PF02662
(FlpD) 		5 PHE D  55
LEU D  50
ALA D  54
ALA D  59
LEU D 129
 None
 1.14A 1cbrA-5odrD:
undetectable		 1cbrA-5odrD:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47

(Homo sapiens;
Human
alphaherpesvirus
1) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF05363
(Herpes_US12) 		5 LEU B 164
ALA B 162
ALA B 207
LEU X   5
TYR A 408
 None
 1.18A 1cbrA-5u1dB:
undetectable		 1cbrA-5u1dB:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		5 LEU A 106
ALA A  72
PRO A 350
THR A 236
LEU A 373
 AMP  A 524 (-4.4A)
AMP  A 524 ( 3.2A)
None
None
None
 1.28A 1cbrA-5veoA:
undetectable		 1cbrA-5veoA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvm CADHERIN-23

(Homo sapiens) 		no annotation 5 LEU A2399
ALA A2403
PRO A2377
VAL A2470
LEU A2413
 None
 1.26A 1cbrA-5vvmA:
undetectable		 1cbrA-5vvmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
UNCHARACTERIZED
PROTEIN

(Leishmania
major) 		no annotation 5 LEU B  14
ALA B  17
ALA B  20
VAL A  50
ARG A  58
 None
 1.27A 1cbrA-5wb5B:
undetectable		 1cbrA-5wb5B:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuf PUTATIVE MEMBRANE
PROTEIN

(Colwellia
psychrerythraea) 		PF03458
(UPF0126) 		5 LEU A 153
ALA A 155
ALA A 103
THR A 107
LEU A   8
 None
 1.19A 1cbrA-5wufA:
undetectable		 1cbrA-5wufA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6i -

(-) 		no annotation 5 LEU A  94
ALA A  97
THR A 252
VAL A 216
LEU A 108
 None
 1.28A 1cbrA-5y6iA:
undetectable		 1cbrA-5y6iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E

(Pseudomonas sp.
AIU 813) 		no annotation 5 PHE A 535
LEU A 328
ALA A 326
ALA A 325
ARG A  43
 None
 1.10A 1cbrA-5yb7A:
undetectable		 1cbrA-5yb7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bn2 ACETYL-COA
ACETYLTRANSFERASE

(Elizabethkingia
anophelis) 		no annotation 5 LEU A  29
ALA A  33
ALA A  37
VAL A 199
LEU A 258
 None
 1.19A 1cbrA-6bn2A:
undetectable		 1cbrA-6bn2A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 5 LEU A 150
ALA A 151
ALA A  16
THR A  80
VAL A 106
 None
 1.09A 1cbrA-6cipA:
undetectable		 1cbrA-6cipA:
18.71