SIMILAR PATTERNS OF AMINO ACIDS FOR 1C9S_U_TRPU81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.76A 1c9sU-1ajoA:
1.3
1c9sV-1ajoA:
1.2		 1c9sU-1ajoA:
18.54
1c9sV-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.75A 1c9sU-1axkA:
1.0
1c9sV-1axkA:
2.0		 1c9sU-1axkA:
11.17
1c9sV-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 GLY A 118
ALA A  25
THR A 125
THR A  82
 None
 0.69A 1c9sU-1c3xA:
undetectable
1c9sV-1c3xA:
undetectable		 1c9sU-1c3xA:
14.98
1c9sV-1c3xA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.76A 1c9sU-1cpnA:
2.0
1c9sV-1cpnA:
0.0		 1c9sU-1cpnA:
15.35
1c9sV-1cpnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 GLY A 344
ALA A 318
HIS A 283
THR A 284
 None
 0.77A 1c9sU-1f26A:
undetectable
1c9sV-1f26A:
undetectable		 1c9sU-1f26A:
11.72
1c9sV-1f26A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 GLY A 194
THR A 356
ILE A 197
SER A 137
 SF4  A 582 (-3.9A)
None
None
None
 0.76A 1c9sU-1fehA:
undetectable
1c9sV-1fehA:
undetectable		 1c9sU-1fehA:
9.41
1c9sV-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.63A 1c9sU-1flgA:
undetectable
1c9sV-1flgA:
undetectable		 1c9sU-1flgA:
8.63
1c9sV-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 ALA A 131
HIS A  77
ILE A 138
THR A  82
 None
 0.77A 1c9sU-1gw1A:
undetectable
1c9sV-1gw1A:
undetectable		 1c9sU-1gw1A:
14.09
1c9sV-1gw1A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 GLY A  11
ALA A  20
ILE A  33
THR A 428
 FAD  A 579 (-3.1A)
None
None
None
 0.80A 1c9sU-1h81A:
undetectable
1c9sV-1h81A:
undetectable		 1c9sU-1h81A:
9.76
1c9sV-1h81A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 GLY A 412
THR A 417
ILE A 479
SER A 245
 None
TRA  A 866 (-4.0A)
None
TRA  A 866 (-2.6A)
 0.81A 1c9sU-1l5jA:
undetectable
1c9sV-1l5jA:
undetectable		 1c9sU-1l5jA:
7.07
1c9sV-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 GLY A 307
ALA A 313
ILE A 309
SER A 315
 None
 0.73A 1c9sU-1l8wA:
undetectable
1c9sV-1l8wA:
undetectable		 1c9sU-1l8wA:
11.14
1c9sV-1l8wA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PO4  A 655 (-3.6A)
None
None
None
 0.78A 1c9sU-1lw3A:
undetectable
1c9sV-1lw3A:
undetectable		 1c9sU-1lw3A:
7.46
1c9sV-1lw3A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.80A 1c9sU-1macA:
undetectable
1c9sV-1macA:
undetectable		 1c9sU-1macA:
17.79
1c9sV-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 GLY B 156
THR B 139
HIS B 103
THR B 137
 None
 0.69A 1c9sU-1mioB:
undetectable
1c9sV-1mioB:
undetectable		 1c9sU-1mioB:
9.76
1c9sV-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 ALA A 420
HIS A 372
THR A 370
ILE A 397
 None
 0.76A 1c9sU-1mlzA:
undetectable
1c9sV-1mlzA:
undetectable		 1c9sU-1mlzA:
12.63
1c9sV-1mlzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ob1 ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  33
HIS B  53
THR B  52
ILE B  34
 None
 0.69A 1c9sU-1ob1B:
undetectable
1c9sV-1ob1B:
undetectable		 1c9sU-1ob1B:
12.50
1c9sV-1ob1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 GLY Q 105
ALA Q  96
THR Q  99
THR Q 376
 None
 0.73A 1c9sU-1oh2Q:
undetectable
1c9sV-1oh2Q:
undetectable		 1c9sU-1oh2Q:
12.04
1c9sV-1oh2Q:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		4 GLY A 131
ALA A 174
THR A  33
ILE A  22
 None
 0.82A 1c9sU-1p3cA:
undetectable
1c9sV-1p3cA:
undetectable		 1c9sU-1p3cA:
16.00
1c9sV-1p3cA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.70A 1c9sU-1ptjA:
undetectable
1c9sV-1ptjA:
undetectable		 1c9sU-1ptjA:
13.14
1c9sV-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 GLY A 175
THR A 126
ILE A 128
SER A  80
 None
 0.79A 1c9sU-1vb4A:
undetectable
1c9sV-1vb4A:
undetectable		 1c9sU-1vb4A:
14.55
1c9sV-1vb4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.67A 1c9sU-1wkmA:
undetectable
1c9sV-1wkmA:
undetectable		 1c9sU-1wkmA:
15.29
1c9sV-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.77A 1c9sU-1y6jA:
undetectable
1c9sV-1y6jA:
undetectable		 1c9sU-1y6jA:
15.48
1c9sV-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.72A 1c9sU-1zsqA:
undetectable
1c9sV-1zsqA:
undetectable		 1c9sU-1zsqA:
12.02
1c9sV-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 GLY A 152
THR A 143
ILE A 163
THR A 399
 None
 0.76A 1c9sU-2ahwA:
undetectable
1c9sV-2ahwA:
undetectable		 1c9sU-2ahwA:
9.98
1c9sV-2ahwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		4 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.75A 1c9sU-2amhA:
undetectable
1c9sV-2amhA:
undetectable		 1c9sU-2amhA:
19.19
1c9sV-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 GLY A   8
ALA A  81
THR A 105
ILE A  49
 None
 0.81A 1c9sU-2cevA:
undetectable
1c9sV-2cevA:
undetectable		 1c9sU-2cevA:
14.81
1c9sV-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.75A 1c9sU-2e28A:
undetectable
1c9sV-2e28A:
undetectable		 1c9sU-2e28A:
9.86
1c9sV-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0r NICOTINAMIDASE

(Saccharomyces
cerevisiae) 		PF00857
(Isochorismatase) 		4 THR A 154
HIS A  44
THR A   3
ILE A   5
 None
 0.81A 1c9sU-2h0rA:
undetectable
1c9sV-2h0rA:
undetectable		 1c9sU-2h0rA:
17.59
1c9sV-2h0rA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.59A 1c9sU-2jifA:
undetectable
1c9sV-2jifA:
undetectable		 1c9sU-2jifA:
10.55
1c9sV-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		4 GLY A  30
ALA A  56
THR A  91
ILE A  31
 None
 0.82A 1c9sU-2p0oA:
undetectable
1c9sV-2p0oA:
undetectable		 1c9sU-2p0oA:
12.84
1c9sV-2p0oA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A 107
ALA A  79
THR A  42
ILE A  16
 GSP  A 401 (-3.6A)
None
GSP  A 401 (-4.5A)
None
 0.79A 1c9sU-2q1yA:
undetectable
1c9sV-2q1yA:
undetectable		 1c9sU-2q1yA:
12.94
1c9sV-2q1yA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 GLY A 358
THR A 207
ILE A 361
SER A 337
 None
 0.69A 1c9sU-2qveA:
undetectable
1c9sV-2qveA:
undetectable		 1c9sU-2qveA:
11.96
1c9sV-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 GLY A 175
THR A 126
ILE A 128
SER A  80
 None
 0.70A 1c9sU-2vq0A:
undetectable
1c9sV-2vq0A:
undetectable		 1c9sU-2vq0A:
13.28
1c9sV-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.80A 1c9sU-2wghA:
undetectable
1c9sV-2wghA:
undetectable		 1c9sU-2wghA:
8.38
1c9sV-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 ALA A 187
THR A 426
THR A 414
ILE A 184
 None
 0.81A 1c9sU-3cb5A:
undetectable
1c9sV-3cb5A:
undetectable		 1c9sU-3cb5A:
9.95
1c9sV-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 GLY A 110
HIS A 134
THR A 135
ILE A 164
 None
 0.63A 1c9sU-3cq5A:
undetectable
1c9sV-3cq5A:
undetectable		 1c9sU-3cq5A:
13.50
1c9sV-3cq5A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8u FAB 106.3 HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  33
HIS H  53
THR H  52
ILE H  34
 None
 0.75A 1c9sU-3e8uH:
undetectable
1c9sV-3e8uH:
undetectable		 1c9sU-3e8uH:
14.95
1c9sV-3e8uH:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 GLY A 251
ALA A 107
THR A 247
ILE A 204
 None
 0.80A 1c9sU-3fmqA:
undetectable
1c9sV-3fmqA:
undetectable		 1c9sU-3fmqA:
13.14
1c9sV-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.75A 1c9sU-3fpzA:
undetectable
1c9sV-3fpzA:
undetectable		 1c9sU-3fpzA:
16.03
1c9sV-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.72A 1c9sU-3hhsB:
undetectable
1c9sV-3hhsB:
undetectable		 1c9sU-3hhsB:
8.46
1c9sV-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		4 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.79A 1c9sU-3i4iA:
undetectable
1c9sV-3i4iA:
undetectable		 1c9sU-3i4iA:
16.44
1c9sV-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 GLY A 116
THR A  70
HIS A 121
SER A  66
 None
 0.61A 1c9sU-3ihaA:
undetectable
1c9sV-3ihaA:
undetectable		 1c9sU-3ihaA:
7.68
1c9sV-3ihaA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  31
ALA A   8
THR A  87
ILE A  81
 None
 0.81A 1c9sU-3ip1A:
undetectable
1c9sV-3ip1A:
undetectable		 1c9sU-3ip1A:
11.50
1c9sV-3ip1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		4 GLY A  58
ALA A 109
ILE A 128
SER A 107
 None
 0.80A 1c9sU-3ktoA:
undetectable
1c9sV-3ktoA:
undetectable		 1c9sU-3ktoA:
18.94
1c9sV-3ktoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3liu PUTATIVE CELL
ADHESION PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		4 GLY A  68
ALA A 122
HIS A 104
ILE A  78
 None
 0.72A 1c9sU-3liuA:
undetectable
1c9sV-3liuA:
undetectable		 1c9sU-3liuA:
12.19
1c9sV-3liuA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii) 		PF02541
(Ppx-GppA) 		4 GLY A 147
THR A 204
HIS A 130
ILE A 146
 None
 0.76A 1c9sU-3mdqA:
undetectable
1c9sV-3mdqA:
undetectable		 1c9sU-3mdqA:
14.24
1c9sV-3mdqA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg6 PROTEASOME COMPONENT
C11

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 GLY J 102
HIS J  40
THR J  41
ILE J 101
 None
 0.82A 1c9sU-3mg6J:
undetectable
1c9sV-3mg6J:
undetectable		 1c9sU-3mg6J:
14.52
1c9sV-3mg6J:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 GLY A  49
ALA A  10
THR A  19
ILE A  50
 None
 0.69A 1c9sU-3myxA:
3.9
1c9sV-3myxA:
3.9		 1c9sU-3myxA:
16.88
1c9sV-3myxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 143
ALA A  82
HIS A  76
ILE A 105
 None
 0.67A 1c9sU-3o04A:
undetectable
1c9sV-3o04A:
undetectable		 1c9sU-3o04A:
12.22
1c9sV-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.75A 1c9sU-3or2B:
undetectable
1c9sV-3or2B:
undetectable		 1c9sU-3or2B:
11.35
1c9sV-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 GLY A  94
ALA A  41
HIS A  38
ILE A  93
 None
 0.80A 1c9sU-3qbdA:
undetectable
1c9sV-3qbdA:
undetectable		 1c9sU-3qbdA:
14.20
1c9sV-3qbdA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.74A 1c9sU-3rotA:
undetectable
1c9sV-3rotA:
undetectable		 1c9sU-3rotA:
13.47
1c9sV-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 GLY A  53
ALA A 251
THR A 274
ILE A 248
 None
 0.73A 1c9sU-3snhA:
undetectable
1c9sV-3snhA:
undetectable		 1c9sU-3snhA:
6.70
1c9sV-3snhA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.63A 1c9sU-3t63M:
undetectable
1c9sV-3t63M:
undetectable		 1c9sU-3t63M:
12.18
1c9sV-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 GLY A  86
THR A 190
ILE A  82
SER A 163
 None
 0.80A 1c9sU-3v4cA:
undetectable
1c9sV-3v4cA:
undetectable		 1c9sU-3v4cA:
10.56
1c9sV-3v4cA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh0 UNCHARACTERIZED
PROTEIN YNCE

(Escherichia
coli) 		no annotation 4 GLY A 172
ALA A 115
ILE A 174
THR A 100
 None
 0.72A 1c9sU-3vh0A:
undetectable
1c9sV-3vh0A:
undetectable		 1c9sU-3vh0A:
12.50
1c9sV-3vh0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 GLY A 391
ALA A 382
THR A 410
SER A 385
 None
 0.68A 1c9sU-3vz0A:
undetectable
1c9sV-3vz0A:
undetectable		 1c9sU-3vz0A:
10.20
1c9sV-3vz0A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 GLY A 133
HIS A 151
THR A 152
ILE A 134
SER A 148
 None
 1.15A 1c9sU-3wpeA:
undetectable
1c9sV-3wpeA:
undetectable		 1c9sU-3wpeA:
7.17
1c9sV-3wpeA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvj BETA-GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00722
(Glyco_hydro_16) 		4 ALA A 113
THR A 146
ILE A 118
SER A 172
 None
 0.77A 1c9sU-3wvjA:
undetectable
1c9sV-3wvjA:
undetectable		 1c9sU-3wvjA:
16.90
1c9sV-3wvjA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-4

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 GLY K 104
HIS K  40
THR K  41
ILE K 103
 None
 0.82A 1c9sU-3wxrK:
undetectable
1c9sV-3wxrK:
undetectable		 1c9sU-3wxrK:
14.29
1c9sV-3wxrK:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 GLY A 209
HIS A 388
THR A 387
ILE A 208
 None
FMN  A 500 (-4.6A)
None
None
 0.80A 1c9sU-3x0yA:
undetectable
1c9sV-3x0yA:
undetectable		 1c9sU-3x0yA:
11.36
1c9sV-3x0yA:
11.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		5 GLY A  23
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
TRP  A  80 (-2.8A)
None
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.22A 1c9sU-3zteA:
14.3
1c9sV-3zteA:
14.3		 1c9sU-3zteA:
78.21
1c9sV-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A  81 (-3.5A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 0.23A 1c9sU-3zzlA:
13.1
1c9sV-3zzlA:
13.1		 1c9sU-3zzlA:
71.43
1c9sV-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.13A 1c9sU-3zzqA:
13.7
1c9sV-3zzqA:
13.7		 1c9sU-3zzqA:
80.00
1c9sV-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.14A 1c9sU-3zzsA:
13.6
1c9sV-3zzsA:
13.5		 1c9sU-3zzsA:
100.00
1c9sV-3zzsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 1c9sU-4b27A:
13.2
1c9sV-4b27A:
13.1		 1c9sU-4b27A:
76.32
1c9sV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		4 GLY A 123
HIS A 140
THR A  39
ILE A 118
 None
 0.82A 1c9sU-4b8sA:
undetectable
1c9sV-4b8sA:
undetectable		 1c9sU-4b8sA:
10.02
1c9sV-4b8sA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 GLY A 400
THR A 499
THR A 449
THR A 395
 None
None
None
EDO  A1590 (-4.9A)
 0.76A 1c9sU-4c22A:
undetectable
1c9sV-4c22A:
undetectable		 1c9sU-4c22A:
8.11
1c9sV-4c22A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		4 ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.79A 1c9sU-4cnkA:
undetectable
1c9sV-4cnkA:
undetectable		 1c9sU-4cnkA:
12.76
1c9sV-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 GLY A 179
ALA A 188
THR A 246
ILE A 177
 None
 0.75A 1c9sU-4dvjA:
undetectable
1c9sV-4dvjA:
undetectable		 1c9sU-4dvjA:
12.98
1c9sV-4dvjA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2p CYTOCHROME P450
107B1 (P450CVIIB1)

(Streptomyces
himastatinicus) 		PF00067
(p450) 		4 GLY A 340
ALA A  43
HIS A 344
THR A 286
 HEM  A 401 ( 4.1A)
None
HEM  A 401 (-3.9A)
HEM  A 401 (-3.3A)
 0.81A 1c9sU-4e2pA:
undetectable
1c9sV-4e2pA:
undetectable		 1c9sU-4e2pA:
10.50
1c9sV-4e2pA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A 107
ALA A  79
THR A  42
ILE A  16
 SO4  A 607 (-3.4A)
None
None
None
 0.70A 1c9sU-4e6eA:
undetectable
1c9sV-4e6eA:
undetectable		 1c9sU-4e6eA:
12.06
1c9sV-4e6eA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  33
ALA H  24
THR H  53
ILE H  34
 None
 0.71A 1c9sU-4eowH:
undetectable
1c9sV-4eowH:
undetectable		 1c9sU-4eowH:
14.91
1c9sV-4eowH:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 GLY B 191
THR B 339
ILE B 194
THR B 169
 None
 0.80A 1c9sU-4i6mB:
undetectable
1c9sV-4i6mB:
undetectable		 1c9sU-4i6mB:
11.93
1c9sV-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 GLY A  78
ALA A 198
ILE A  79
SER A 200
 None
 0.76A 1c9sU-4isyA:
undetectable
1c9sV-4isyA:
undetectable		 1c9sU-4isyA:
11.50
1c9sV-4isyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 GLY A 771
ALA A 596
THR A 207
ILE A 770
 None
 0.77A 1c9sU-4lglA:
undetectable
1c9sV-4lglA:
undetectable		 1c9sU-4lglA:
5.61
1c9sV-4lglA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqq DEOXYRIBONUCLEOSIDE
REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		4 ALA A 278
HIS A 304
THR A 305
ILE A 287
 None
 0.75A 1c9sU-4oqqA:
undetectable
1c9sV-4oqqA:
undetectable		 1c9sU-4oqqA:
14.63
1c9sV-4oqqA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 GLY B 588
HIS B 595
THR B 591
ILE B 587
 None
 0.83A 1c9sU-4rkuB:
undetectable
1c9sV-4rkuB:
undetectable		 1c9sU-4rkuB:
6.84
1c9sV-4rkuB:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 ALA A 115
THR A 326
THR A  67
ILE A 123
 None
 0.77A 1c9sU-4v1yA:
undetectable
1c9sV-4v1yA:
undetectable		 1c9sU-4v1yA:
10.51
1c9sV-4v1yA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  68
ALA A 129
ILE A  90
THR A 345
 None
 0.70A 1c9sU-4w6zA:
undetectable
1c9sV-4w6zA:
undetectable		 1c9sU-4w6zA:
11.53
1c9sV-4w6zA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xat NOELIN

(Homo sapiens) 		PF02191
(OLF) 		4 ALA A 366
THR A 389
ILE A 320
SER A 380
 None
 0.73A 1c9sU-4xatA:
undetectable
1c9sV-4xatA:
undetectable		 1c9sU-4xatA:
15.15
1c9sV-4xatA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN

(Helicobacter
pylori) 		no annotation 4 GLY A 375
ALA A  92
THR A 432
ILE A 378
 None
 0.77A 1c9sU-4zh7A:
undetectable
1c9sV-4zh7A:
undetectable		 1c9sU-4zh7A:
8.78
1c9sV-4zh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 441
THR A 449
THR A 445
SER A 292
 PO4  A 701 (-3.5A)
None
None
None
 0.67A 1c9sU-5c16A:
undetectable
1c9sV-5c16A:
undetectable		 1c9sU-5c16A:
8.93
1c9sV-5c16A:
8.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 None
 0.19A 1c9sU-5eexA:
15.5
1c9sV-5eexA:
15.4		 1c9sU-5eexA:
100.00
1c9sV-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 4 GLY A 369
ALA A  92
THR A 426
ILE A 372
 None
 0.76A 1c9sU-5f9aA:
undetectable
1c9sV-5f9aA:
undetectable		 1c9sU-5f9aA:
11.67
1c9sV-5f9aA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		4 GLY A 127
HIS A 153
THR A 154
SER A 148
 None
None
None
SAH  A 409 ( 4.2A)
 0.80A 1c9sU-5fubA:
undetectable
1c9sV-5fubA:
undetectable		 1c9sU-5fubA:
14.50
1c9sV-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		4 GLY A 161
HIS A 187
THR A 188
SER A 182
 None
None
None
SAH  A1446 ( 4.4A)
 0.81A 1c9sU-5fulA:
undetectable
1c9sV-5fulA:
undetectable		 1c9sU-5fulA:
10.25
1c9sV-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 GLY A  28
ALA A 114
THR A  98
ILE A  96
 None
 0.80A 1c9sU-5h7jA:
undetectable
1c9sV-5h7jA:
undetectable		 1c9sU-5h7jA:
undetectable
1c9sV-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		4 GLY A 274
ALA A 400
THR A 377
THR A 308
 None
 0.82A 1c9sU-5j84A:
undetectable
1c9sV-5j84A:
undetectable		 1c9sU-5j84A:
8.03
1c9sV-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Homo sapiens) 		no annotation 4 HIS B 241
THR B 242
ILE B 256
SER B 219
 None
 0.80A 1c9sU-5nnzB:
undetectable
1c9sV-5nnzB:
undetectable		 1c9sU-5nnzB:
11.55
1c9sV-5nnzB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 409
THR A 339
THR A 368
ILE A 366
 None
 0.77A 1c9sU-5olpA:
undetectable
1c9sV-5olpA:
undetectable		 1c9sU-5olpA:
10.47
1c9sV-5olpA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		4 GLY A 165
ALA A 103
THR A  21
ILE A 168
 None
 0.74A 1c9sU-5sy4A:
undetectable
1c9sV-5sy4A:
undetectable		 1c9sU-5sy4A:
17.62
1c9sV-5sy4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 261
ALA A 198
THR A 258
ILE A 254
 None
 0.71A 1c9sU-5tnxA:
undetectable
1c9sV-5tnxA:
undetectable		 1c9sU-5tnxA:
11.17
1c9sV-5tnxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.80A 1c9sU-5tusA:
undetectable
1c9sV-5tusA:
undetectable		 1c9sU-5tusA:
7.41
1c9sV-5tusA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 4 GLY A 225
THR A 278
ILE A 269
THR A  20
 None
 0.81A 1c9sU-5u6fA:
undetectable
1c9sV-5u6fA:
undetectable		 1c9sU-5u6fA:
undetectable
1c9sV-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		4 GLY A 237
ALA A 242
ILE A 238
SER A 244
 None
 0.82A 1c9sU-5wayA:
undetectable
1c9sV-5wayA:
undetectable		 1c9sU-5wayA:
9.85
1c9sV-5wayA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 4 GLY A  71
ALA A 132
ILE A  93
THR A 348
 None
 0.66A 1c9sU-5yatA:
undetectable
1c9sV-5yatA:
undetectable		 1c9sU-5yatA:
undetectable
1c9sV-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 GLY A 134
HIS A 152
THR A 153
ILE A 135
SER A 149
 None
 1.10A 1c9sU-5zlnA:
undetectable
1c9sV-5zlnA:
undetectable		 1c9sU-5zlnA:
undetectable
1c9sV-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 4 GLY A 360
ALA A 415
ILE A 363
THR A 396
 None
 0.79A 1c9sU-6c0eA:
undetectable
1c9sV-6c0eA:
undetectable		 1c9sU-6c0eA:
undetectable
1c9sV-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 4 GLY B 586
HIS B 593
THR B 589
ILE B 585
 None
 0.81A 1c9sU-6fosB:
undetectable
1c9sV-6fosB:
undetectable		 1c9sU-6fosB:
undetectable
1c9sV-6fosB:
undetectable