SIMILAR PATTERNS OF AMINO ACIDS FOR 1C9S_J_TRPJ81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 SER A  15
ALA A 170
THR A 203
ILE A 175
 None
 0.79A 1c9sI-1ajoA:
1.3
1c9sJ-1ajoA:
0.9		 1c9sI-1ajoA:
18.54
1c9sJ-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 SER A  83
ALA A  24
THR A  57
ILE A  29
 None
 0.78A 1c9sI-1axkA:
2.3
1c9sJ-1axkA:
1.1		 1c9sI-1axkA:
11.17
1c9sJ-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 SER A  83
ALA A  24
THR A  57
ILE A  29
 None
 0.79A 1c9sI-1cpnA:
1.0
1c9sJ-1cpnA:
1.1		 1c9sI-1cpnA:
15.35
1c9sJ-1cpnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 GLY A 344
ALA A 318
HIS A 283
THR A 284
 None
 0.72A 1c9sI-1f26A:
undetectable
1c9sJ-1f26A:
undetectable		 1c9sI-1f26A:
11.72
1c9sJ-1f26A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 SER A 137
GLY A 194
THR A 356
ILE A 197
 None
SF4  A 582 (-3.9A)
None
None
 0.80A 1c9sI-1fehA:
undetectable
1c9sJ-1fehA:
undetectable		 1c9sI-1fehA:
9.41
1c9sJ-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.68A 1c9sI-1flgA:
undetectable
1c9sJ-1flgA:
undetectable		 1c9sI-1flgA:
8.63
1c9sJ-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 THR A 428
GLY A  11
ALA A  20
ILE A  33
 None
FAD  A 579 (-3.1A)
None
None
 0.79A 1c9sI-1h81A:
undetectable
1c9sJ-1h81A:
undetectable		 1c9sI-1h81A:
9.76
1c9sJ-1h81A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 SER A 245
GLY A 412
THR A 417
ILE A 479
 TRA  A 866 (-2.6A)
None
TRA  A 866 (-4.0A)
None
 0.82A 1c9sI-1l5jA:
undetectable
1c9sJ-1l5jA:
undetectable		 1c9sI-1l5jA:
7.07
1c9sJ-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 SER A 315
GLY A 307
ALA A 313
ILE A 309
 None
 0.69A 1c9sI-1l8wA:
undetectable
1c9sJ-1l8wA:
undetectable		 1c9sI-1l8wA:
11.14
1c9sJ-1l8wA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 GLY B 156
THR B 139
HIS B 103
THR B 137
 None
 0.67A 1c9sI-1mioB:
undetectable
1c9sJ-1mioB:
undetectable		 1c9sI-1mioB:
9.76
1c9sJ-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 ALA A 420
HIS A 372
THR A 370
ILE A 397
 None
 0.81A 1c9sI-1mlzA:
undetectable
1c9sJ-1mlzA:
undetectable		 1c9sI-1mlzA:
12.63
1c9sJ-1mlzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 THR Q 376
GLY Q 105
ALA Q  96
THR Q  99
 None
 0.72A 1c9sI-1oh2Q:
undetectable
1c9sJ-1oh2Q:
undetectable		 1c9sI-1oh2Q:
12.04
1c9sJ-1oh2Q:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.72A 1c9sI-1ptjA:
undetectable
1c9sJ-1ptjA:
undetectable		 1c9sI-1ptjA:
13.14
1c9sJ-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Escherichia
coli) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 THR A 312
GLY A  10
ALA A  23
ILE A  36
 None
 0.81A 1c9sI-1qmhA:
undetectable
1c9sJ-1qmhA:
undetectable		 1c9sI-1qmhA:
15.23
1c9sJ-1qmhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.81A 1c9sI-1vb4A:
undetectable
1c9sJ-1vb4A:
undetectable		 1c9sI-1vb4A:
14.55
1c9sJ-1vb4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.65A 1c9sI-1wkmA:
undetectable
1c9sJ-1wkmA:
undetectable		 1c9sI-1wkmA:
15.29
1c9sJ-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.77A 1c9sI-1y6jA:
undetectable
1c9sJ-1y6jA:
undetectable		 1c9sI-1y6jA:
15.48
1c9sJ-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.76A 1c9sI-1zsqA:
undetectable
1c9sJ-1zsqA:
undetectable		 1c9sI-1zsqA:
12.02
1c9sJ-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 THR A 399
GLY A 152
THR A 143
ILE A 163
 None
 0.75A 1c9sI-2ahwA:
undetectable
1c9sJ-2ahwA:
undetectable		 1c9sI-2ahwA:
9.98
1c9sJ-2ahwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		4 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.76A 1c9sI-2amhA:
undetectable
1c9sJ-2amhA:
undetectable		 1c9sI-2amhA:
19.19
1c9sJ-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2i RV0130

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 THR A  58
GLY A 103
ALA A  61
ILE A  26
 None
 0.81A 1c9sI-2c2iA:
undetectable
1c9sJ-2c2iA:
undetectable		 1c9sI-2c2iA:
22.14
1c9sJ-2c2iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 GLY A   8
ALA A  81
THR A 105
ILE A  49
 None
 0.79A 1c9sI-2cevA:
undetectable
1c9sJ-2cevA:
undetectable		 1c9sI-2cevA:
14.81
1c9sJ-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		4 THR A 189
SER A  18
ALA A  22
ILE A  67
 None
SO4  A5001 (-2.7A)
None
None
 0.79A 1c9sI-2detA:
undetectable
1c9sJ-2detA:
undetectable		 1c9sI-2detA:
11.89
1c9sJ-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 THR A 517
GLY A 546
ALA A 528
ILE A 551
 None
 0.75A 1c9sI-2e28A:
undetectable
1c9sJ-2e28A:
undetectable		 1c9sI-2e28A:
9.86
1c9sJ-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 319
GLY A 182
ALA A 208
THR A 185
 None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
 0.73A 1c9sI-2eerA:
undetectable
1c9sJ-2eerA:
undetectable		 1c9sI-2eerA:
13.02
1c9sJ-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 GLY A 145
ALA A  92
THR A  84
ILE A 149
 None
 0.80A 1c9sI-2g02A:
undetectable
1c9sJ-2g02A:
undetectable		 1c9sI-2g02A:
9.83
1c9sJ-2g02A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.58A 1c9sI-2jifA:
undetectable
1c9sJ-2jifA:
undetectable		 1c9sI-2jifA:
10.55
1c9sJ-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A 107
ALA A  79
THR A  42
ILE A  16
 GSP  A 401 (-3.6A)
None
GSP  A 401 (-4.5A)
None
 0.78A 1c9sI-2q1yA:
undetectable
1c9sJ-2q1yA:
undetectable		 1c9sI-2q1yA:
12.94
1c9sJ-2q1yA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 SER A 337
GLY A 358
THR A 207
ILE A 361
 None
 0.68A 1c9sI-2qveA:
undetectable
1c9sJ-2qveA:
undetectable		 1c9sI-2qveA:
11.96
1c9sJ-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.71A 1c9sI-2vq0A:
undetectable
1c9sJ-2vq0A:
undetectable		 1c9sI-2vq0A:
13.28
1c9sJ-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 SER A 543
GLY A 502
ALA A 539
ILE A 599
 None
 0.80A 1c9sI-2wghA:
undetectable
1c9sJ-2wghA:
undetectable		 1c9sI-2wghA:
8.38
1c9sJ-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 THR A 112
SER A  74
GLY A 166
THR A 178
THR A 179
 NAD  A3001 ( 4.5A)
None
NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
 1.36A 1c9sI-3a1nA:
undetectable
1c9sJ-3a1nA:
undetectable		 1c9sI-3a1nA:
13.02
1c9sJ-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 ALA A 187
THR A 426
THR A 414
ILE A 184
 None
 0.78A 1c9sI-3cb5A:
undetectable
1c9sJ-3cb5A:
undetectable		 1c9sI-3cb5A:
9.95
1c9sJ-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 GLY A 110
HIS A 134
THR A 135
ILE A 164
 None
 0.70A 1c9sI-3cq5A:
undetectable
1c9sJ-3cq5A:
undetectable		 1c9sI-3cq5A:
13.50
1c9sJ-3cq5A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8u FAB 106.3 HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  33
HIS H  53
THR H  52
ILE H  34
 None
 0.76A 1c9sI-3e8uH:
undetectable
1c9sJ-3e8uH:
undetectable		 1c9sI-3e8uH:
14.95
1c9sJ-3e8uH:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 GLY A 251
ALA A 107
THR A 247
ILE A 204
 None
 0.79A 1c9sI-3fmqA:
undetectable
1c9sJ-3fmqA:
undetectable		 1c9sI-3fmqA:
13.14
1c9sJ-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		4 THR A 272
GLY A 184
ALA A 280
ILE A 188
 None
 0.81A 1c9sI-3fvrA:
undetectable
1c9sJ-3fvrA:
undetectable		 1c9sI-3fvrA:
14.60
1c9sJ-3fvrA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		4 THR A 173
SER A 141
THR A  56
ILE A  54
 None
None
NA  A 358 (-4.0A)
None
 0.75A 1c9sI-3h84A:
undetectable
1c9sJ-3h84A:
undetectable		 1c9sI-3h84A:
12.99
1c9sJ-3h84A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.70A 1c9sI-3hhsB:
undetectable
1c9sJ-3hhsB:
undetectable		 1c9sI-3hhsB:
8.46
1c9sJ-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		4 SER A 143
ALA A  84
THR A 117
ILE A  89
 None
 0.82A 1c9sI-3i4iA:
undetectable
1c9sJ-3i4iA:
undetectable		 1c9sI-3i4iA:
16.44
1c9sJ-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 SER A  66
GLY A 116
THR A  70
HIS A 121
 None
 0.63A 1c9sI-3ihaA:
undetectable
1c9sJ-3ihaA:
undetectable		 1c9sI-3ihaA:
7.68
1c9sJ-3ihaA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  31
ALA A   8
THR A  87
ILE A  81
 None
 0.80A 1c9sI-3ip1A:
undetectable
1c9sJ-3ip1A:
undetectable		 1c9sI-3ip1A:
11.50
1c9sJ-3ip1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 THR F 333
GLY F 366
THR F 364
ILE F 401
 None
 0.78A 1c9sI-3jbrF:
undetectable
1c9sJ-3jbrF:
undetectable		 1c9sI-3jbrF:
5.20
1c9sJ-3jbrF:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		4 SER A 107
GLY A  58
ALA A 109
ILE A 128
 None
 0.81A 1c9sI-3ktoA:
undetectable
1c9sJ-3ktoA:
undetectable		 1c9sI-3ktoA:
18.94
1c9sJ-3ktoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3liu PUTATIVE CELL
ADHESION PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		4 GLY A  68
ALA A 122
HIS A 104
ILE A  78
 None
 0.75A 1c9sI-3liuA:
undetectable
1c9sJ-3liuA:
undetectable		 1c9sI-3liuA:
12.19
1c9sJ-3liuA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii) 		PF02541
(Ppx-GppA) 		4 GLY A 147
THR A 204
HIS A 130
ILE A 146
 None
 0.79A 1c9sI-3mdqA:
undetectable
1c9sJ-3mdqA:
undetectable		 1c9sI-3mdqA:
14.24
1c9sJ-3mdqA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 GLY A  49
ALA A  10
THR A  19
ILE A  50
 None
 0.67A 1c9sI-3myxA:
undetectable
1c9sJ-3myxA:
4.1		 1c9sI-3myxA:
16.88
1c9sJ-3myxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 143
ALA A  82
HIS A  76
ILE A 105
 None
 0.71A 1c9sI-3o04A:
undetectable
1c9sJ-3o04A:
undetectable		 1c9sI-3o04A:
12.22
1c9sJ-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.75A 1c9sI-3or2B:
undetectable
1c9sJ-3or2B:
undetectable		 1c9sI-3or2B:
11.35
1c9sJ-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus) 		PF02126
(PTE) 		4 ALA A 189
HIS A 178
THR A 177
ILE A 202
 None
CO  A 328 (-3.3A)
None
None
 0.81A 1c9sI-3orwA:
undetectable
1c9sJ-3orwA:
undetectable		 1c9sI-3orwA:
14.98
1c9sJ-3orwA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 GLY A  94
ALA A  41
HIS A  38
ILE A  93
 None
 0.78A 1c9sI-3qbdA:
undetectable
1c9sJ-3qbdA:
undetectable		 1c9sI-3qbdA:
14.20
1c9sJ-3qbdA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 GLY A  53
ALA A 251
THR A 274
ILE A 248
 None
 0.76A 1c9sI-3snhA:
undetectable
1c9sJ-3snhA:
undetectable		 1c9sI-3snhA:
6.70
1c9sJ-3snhA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.60A 1c9sI-3t63M:
undetectable
1c9sJ-3t63M:
undetectable		 1c9sI-3t63M:
12.18
1c9sJ-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 SER A 163
GLY A  86
THR A 190
ILE A  82
 None
 0.76A 1c9sI-3v4cA:
undetectable
1c9sJ-3v4cA:
undetectable		 1c9sI-3v4cA:
10.56
1c9sJ-3v4cA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh0 UNCHARACTERIZED
PROTEIN YNCE

(Escherichia
coli) 		no annotation 4 THR A 100
GLY A 172
ALA A 115
ILE A 174
 None
 0.70A 1c9sI-3vh0A:
undetectable
1c9sJ-3vh0A:
undetectable		 1c9sI-3vh0A:
12.50
1c9sJ-3vh0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 SER A 385
GLY A 391
ALA A 382
THR A 410
 None
 0.72A 1c9sI-3vz0A:
undetectable
1c9sJ-3vz0A:
undetectable		 1c9sI-3vz0A:
10.20
1c9sJ-3vz0A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 148
GLY A 133
HIS A 151
THR A 152
ILE A 134
 None
 1.17A 1c9sI-3wpeA:
undetectable
1c9sJ-3wpeA:
undetectable		 1c9sI-3wpeA:
7.17
1c9sJ-3wpeA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvj BETA-GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00722
(Glyco_hydro_16) 		4 SER A 172
ALA A 113
THR A 146
ILE A 118
 None
 0.80A 1c9sI-3wvjA:
undetectable
1c9sJ-3wvjA:
undetectable		 1c9sI-3wvjA:
16.90
1c9sJ-3wvjA:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		5 GLY A  23
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
TRP  A  80 (-2.8A)
None
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.20A 1c9sI-3zteA:
15.4
1c9sJ-3zteA:
14.4		 1c9sI-3zteA:
78.21
1c9sJ-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A  81 (-3.5A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 0.21A 1c9sI-3zzlA:
13.3
1c9sJ-3zzlA:
13.5		 1c9sI-3zzlA:
71.43
1c9sJ-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.15A 1c9sI-3zzqA:
13.9
1c9sJ-3zzqA:
14.1		 1c9sI-3zzqA:
80.00
1c9sJ-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.10A 1c9sI-3zzsA:
13.9
1c9sJ-3zzsA:
14.1		 1c9sI-3zzsA:
100.00
1c9sJ-3zzsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 1c9sI-4b27A:
13.4
1c9sJ-4b27A:
13.5		 1c9sI-4b27A:
76.32
1c9sJ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 THR A 395
GLY A 400
THR A 499
THR A 449
 EDO  A1590 (-4.9A)
None
None
None
 0.76A 1c9sI-4c22A:
undetectable
1c9sJ-4c22A:
undetectable		 1c9sI-4c22A:
8.11
1c9sJ-4c22A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		4 ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.78A 1c9sI-4cnkA:
undetectable
1c9sJ-4cnkA:
undetectable		 1c9sI-4cnkA:
12.76
1c9sJ-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 GLY A 179
ALA A 188
THR A 246
ILE A 177
 None
 0.74A 1c9sI-4dvjA:
undetectable
1c9sJ-4dvjA:
undetectable		 1c9sI-4dvjA:
12.98
1c9sJ-4dvjA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A 107
ALA A  79
THR A  42
ILE A  16
 SO4  A 607 (-3.4A)
None
None
None
 0.69A 1c9sI-4e6eA:
undetectable
1c9sJ-4e6eA:
undetectable		 1c9sI-4e6eA:
12.06
1c9sJ-4e6eA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  33
ALA H  24
THR H  53
ILE H  34
 None
 0.69A 1c9sI-4eowH:
undetectable
1c9sJ-4eowH:
undetectable		 1c9sI-4eowH:
14.91
1c9sJ-4eowH:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		4 SER A 811
GLY A 389
THR A 626
ILE A 387
 None
FAD  A 901 (-3.3A)
None
None
 0.81A 1c9sI-4hsuA:
undetectable
1c9sJ-4hsuA:
undetectable		 1c9sI-4hsuA:
7.64
1c9sJ-4hsuA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 THR B 169
GLY B 191
THR B 339
ILE B 194
 None
 0.81A 1c9sI-4i6mB:
undetectable
1c9sJ-4i6mB:
undetectable		 1c9sI-4i6mB:
11.93
1c9sJ-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 SER A 200
GLY A  78
ALA A 198
ILE A  79
 None
 0.75A 1c9sI-4isyA:
undetectable
1c9sJ-4isyA:
undetectable		 1c9sI-4isyA:
11.50
1c9sJ-4isyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		4 GLY A  45
ALA A  53
THR A 328
ILE A  43
 FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.8A)
None
 0.80A 1c9sI-4iv9A:
undetectable
1c9sJ-4iv9A:
undetectable		 1c9sI-4iv9A:
9.93
1c9sJ-4iv9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 GLY A 771
ALA A 596
THR A 207
ILE A 770
 None
 0.77A 1c9sI-4lglA:
undetectable
1c9sJ-4lglA:
undetectable		 1c9sI-4lglA:
5.61
1c9sJ-4lglA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqq DEOXYRIBONUCLEOSIDE
REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		4 ALA A 278
HIS A 304
THR A 305
ILE A 287
 None
 0.71A 1c9sI-4oqqA:
undetectable
1c9sJ-4oqqA:
undetectable		 1c9sI-4oqqA:
14.63
1c9sJ-4oqqA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 GLY B 588
HIS B 595
THR B 591
ILE B 587
 None
 0.81A 1c9sI-4rkuB:
undetectable
1c9sJ-4rkuB:
undetectable		 1c9sI-4rkuB:
6.84
1c9sJ-4rkuB:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 ALA A 115
THR A 326
THR A  67
ILE A 123
 None
 0.79A 1c9sI-4v1yA:
undetectable
1c9sJ-4v1yA:
undetectable		 1c9sI-4v1yA:
10.51
1c9sJ-4v1yA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 345
GLY A  68
ALA A 129
ILE A  90
 None
 0.70A 1c9sI-4w6zA:
undetectable
1c9sJ-4w6zA:
undetectable		 1c9sI-4w6zA:
11.53
1c9sJ-4w6zA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		4 GLY A  58
ALA A   8
THR A  82
ILE A  52
 None
 0.79A 1c9sI-4wjmA:
undetectable
1c9sJ-4wjmA:
undetectable		 1c9sI-4wjmA:
13.11
1c9sJ-4wjmA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		4 SER A  64
ALA A  68
THR A 290
ILE A  51
 None
 0.82A 1c9sI-4wr2A:
undetectable
1c9sJ-4wr2A:
undetectable		 1c9sI-4wr2A:
11.64
1c9sJ-4wr2A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 THR A 405
GLY A 251
ALA A 430
HIS A 453
 None
 0.75A 1c9sI-4yweA:
undetectable
1c9sJ-4yweA:
undetectable		 1c9sI-4yweA:
8.54
1c9sJ-4yweA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN

(Helicobacter
pylori) 		no annotation 4 GLY A 375
ALA A  92
THR A 432
ILE A 378
 None
 0.74A 1c9sI-4zh7A:
undetectable
1c9sJ-4zh7A:
undetectable		 1c9sI-4zh7A:
8.78
1c9sJ-4zh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 292
GLY A 441
THR A 449
THR A 445
 None
PO4  A 701 (-3.5A)
None
None
 0.71A 1c9sI-5c16A:
undetectable
1c9sJ-5c16A:
undetectable		 1c9sI-5c16A:
8.93
1c9sJ-5c16A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 THR A 211
ALA A 260
THR A 217
ILE A 219
 None
 0.82A 1c9sI-5cfaA:
undetectable
1c9sJ-5cfaA:
undetectable		 1c9sI-5cfaA:
14.65
1c9sJ-5cfaA:
14.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 None
 0.12A 1c9sI-5eexA:
15.5
1c9sJ-5eexA:
15.3		 1c9sI-5eexA:
100.00
1c9sJ-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 4 GLY A 369
ALA A  92
THR A 426
ILE A 372
 None
 0.73A 1c9sI-5f9aA:
undetectable
1c9sJ-5f9aA:
undetectable		 1c9sI-5f9aA:
11.67
1c9sJ-5f9aA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		4 SER A 148
GLY A 127
HIS A 153
THR A 154
 SAH  A 409 ( 4.2A)
None
None
None
 0.75A 1c9sI-5fubA:
undetectable
1c9sJ-5fubA:
undetectable		 1c9sI-5fubA:
14.50
1c9sJ-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		4 SER A 182
GLY A 161
HIS A 187
THR A 188
 SAH  A1446 ( 4.4A)
None
None
None
 0.76A 1c9sI-5fulA:
undetectable
1c9sJ-5fulA:
undetectable		 1c9sI-5fulA:
10.25
1c9sJ-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00466
(Ribosomal_L10) 		4 THR i 266
GLY i  87
ALA i 259
HIS i 264
 None
 0.81A 1c9sI-5gafi:
undetectable
1c9sJ-5gafi:
undetectable		 1c9sI-5gafi:
12.30
1c9sJ-5gafi:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 GLY A  28
ALA A 114
THR A  98
ILE A  96
 None
 0.78A 1c9sI-5h7jA:
undetectable
1c9sJ-5h7jA:
undetectable		 1c9sI-5h7jA:
undetectable
1c9sJ-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 GLY A 635
ALA A 648
THR A 570
HIS A 638
 None
 0.70A 1c9sI-5jxfA:
undetectable
1c9sJ-5jxfA:
undetectable		 1c9sI-5jxfA:
7.11
1c9sJ-5jxfA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 409
THR A 339
THR A 368
ILE A 366
 None
 0.74A 1c9sI-5olpA:
undetectable
1c9sJ-5olpA:
undetectable		 1c9sI-5olpA:
10.47
1c9sJ-5olpA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		4 GLY A 165
ALA A 103
THR A  21
ILE A 168
 None
 0.72A 1c9sI-5sy4A:
undetectable
1c9sJ-5sy4A:
undetectable		 1c9sI-5sy4A:
17.62
1c9sJ-5sy4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 261
ALA A 198
THR A 258
ILE A 254
 None
 0.70A 1c9sI-5tnxA:
undetectable
1c9sJ-5tnxA:
undetectable		 1c9sI-5tnxA:
11.17
1c9sJ-5tnxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 SER A 543
GLY A 502
ALA A 539
ILE A 599
 None
 0.80A 1c9sI-5tusA:
undetectable
1c9sJ-5tusA:
undetectable		 1c9sI-5tusA:
7.41
1c9sJ-5tusA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 4 THR A  20
GLY A 225
THR A 278
ILE A 269
 None
 0.80A 1c9sI-5u6fA:
undetectable
1c9sJ-5u6fA:
undetectable		 1c9sI-5u6fA:
undetectable
1c9sJ-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		4 SER A 244
GLY A 237
ALA A 242
ILE A 238
 None
 0.81A 1c9sI-5wayA:
undetectable
1c9sJ-5wayA:
undetectable		 1c9sI-5wayA:
9.85
1c9sJ-5wayA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 4 THR A 348
GLY A  71
ALA A 132
ILE A  93
 None
 0.67A 1c9sI-5yatA:
undetectable
1c9sJ-5yatA:
undetectable		 1c9sI-5yatA:
undetectable
1c9sJ-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 SER A 149
GLY A 134
HIS A 152
THR A 153
ILE A 135
 None
 1.12A 1c9sI-5zlnA:
undetectable
1c9sJ-5zlnA:
undetectable		 1c9sI-5zlnA:
undetectable
1c9sJ-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 4 THR A 396
GLY A 360
ALA A 415
ILE A 363
 None
 0.79A 1c9sI-6c0eA:
undetectable
1c9sJ-6c0eA:
undetectable		 1c9sI-6c0eA:
undetectable
1c9sJ-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 4 GLY B 586
HIS B 593
THR B 589
ILE B 585
 None
 0.81A 1c9sI-6fosB:
undetectable
1c9sJ-6fosB:
undetectable		 1c9sI-6fosB:
undetectable
1c9sJ-6fosB:
undetectable