SIMILAR PATTERNS OF AMINO ACIDS FOR 1C8L_A_CFFA940

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
4 ASN A 260
PHE A 261
ALA A 352
GLY A 349
None
0.98A 1c8lA-1aorA:
undetectable
1c8lA-1aorA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayz UBIQUITIN-CONJUGATIN
G ENZYME RAD6


(Saccharomyces
cerevisiae)
PF00179
(UQ_con)
4 ASN A 114
HIS A  78
GLY A  42
TYR A  48
None
1.10A 1c8lA-1ayzA:
undetectable
1c8lA-1ayzA:
11.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e4o MALTODEXTRIN
PHOSPHORYLASE


(Escherichia
coli)
PF00343
(Phosphorylase)
4 HIS A 536
ALA A 575
GLY A 577
TYR A 578
GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
0.73A 1c8lA-1e4oA:
51.0
1c8lA-1e4oA:
42.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
4 ASN A 267
ALA A 239
GLY A 238
TYR A 240
None
1.14A 1c8lA-1ig8A:
0.9
1c8lA-1ig8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE


(Archaeoglobus
fulgidus)
PF02423
(OCD_Mu_crystall)
4 ASN A 214
PHE A 288
ALA A 117
GLY A 114
ASN  A 214 ( 0.6A)
PHE  A 288 ( 1.3A)
ALA  A 117 ( 0.0A)
GLY  A 114 ( 0.0A)
1.08A 1c8lA-1omoA:
undetectable
1c8lA-1omoA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE


(Sus scrofa)
PF01144
(CoA_trans)
4 ASN A  51
PHE A  25
GLY A 385
TYR A  76
None
1.13A 1c8lA-1opeA:
undetectable
1c8lA-1opeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima)
PF00150
(Cellulase)
4 PHE A  30
ALA A  34
GLY A  78
TYR A  77
None
1.10A 1c8lA-1vjzA:
0.4
1c8lA-1vjzA:
15.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
4 HIS A 571
ALA A 610
GLY A 612
TYR A 613
None
0.67A 1c8lA-1ygpA:
45.8
1c8lA-1ygpA:
48.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens)
PF00245
(Alk_phosphatase)
4 ASN A  84
PHE A 107
ALA A  94
GLY A  93
None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
1.03A 1c8lA-1zefA:
undetectable
1c8lA-1zefA:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4m GLYCOGEN
PHOSPHORYLASE


(Corynebacterium
callunae)
PF00343
(Phosphorylase)
4 HIS A 525
ALA A 564
GLY A 566
TYR A 567
None
0.75A 1c8lA-2c4mA:
50.2
1c8lA-2c4mA:
43.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb9 FENGYCIN SYNTHETASE

(Bacillus
subtilis)
PF00975
(Thioesterase)
4 HIS A 201
ALA A 112
GLY A  82
TYR A  83
ACY  A1225 (-3.9A)
None
None
None
1.08A 1c8lA-2cb9A:
6.0
1c8lA-2cb9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3a GLUTAMINE SYNTHETASE

(Zea mays)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
4 HIS A 280
ALA A 283
GLY A 285
TYR A 284
None
1.07A 1c8lA-2d3aA:
0.1
1c8lA-2d3aA:
18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM


(Oryctolagus
cuniculus)
PF00343
(Phosphorylase)
6 ASN A 282
PHE A 285
HIS A 571
ALA A 610
GLY A 612
TYR A 613
None
0.52A 1c8lA-2gj4A:
55.6
1c8lA-2gj4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE


(Sus scrofa)
PF05187
(ETF_QO)
PF13450
(NAD_binding_8)
4 HIS A 216
ALA A 332
GLY A 239
TYR A 238
None
0.93A 1c8lA-2gmhA:
undetectable
1c8lA-2gmhA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY


(Enterococcus
faecalis)
PF13527
(Acetyltransf_9)
PF13530
(SCP2_2)
4 ASN A 247
ALA A 250
GLY A 227
TYR A 245
None
1.14A 1c8lA-2i00A:
undetectable
1c8lA-2i00A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE


(Zymomonas
mobilis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASN A 120
ALA A 332
GLY A 117
TYR A 113
None
None
GOL  A3414 (-3.8A)
None
0.98A 1c8lA-2ox4A:
2.1
1c8lA-2ox4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
4 ASN A 205
PHE A 190
ALA A 189
GLY A 192
None
1.13A 1c8lA-2r3vA:
1.6
1c8lA-2r3vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans)
PF14498
(Glyco_hyd_65N_2)
4 HIS A 421
ALA A 409
GLY A 414
TYR A 413
None
1.11A 1c8lA-2rdyA:
2.4
1c8lA-2rdyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT)
4 ASN G 153
HIS G 500
ALA G 148
GLY G 150
None
0.98A 1c8lA-2uv8G:
0.0
1c8lA-2uv8G:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK


(Geobacillus
kaustophilus)
PF00012
(HSP70)
4 ASN A 121
PHE A 120
ALA A 123
GLY A  72
None
1.12A 1c8lA-2v7yA:
undetectable
1c8lA-2v7yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus)
PF03583
(LIP)
4 HIS A 366
ALA A 187
GLY A 182
TYR A 183
None
1.14A 1c8lA-2veoA:
undetectable
1c8lA-2veoA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN


(Bordetella
bronchiseptica)
PF04183
(IucA_IucC)
PF06276
(FhuF)
4 PHE A 174
HIS A 130
GLY A 181
TYR A 179
None
1.12A 1c8lA-2x0qA:
undetectable
1c8lA-2x0qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8d ERYTHROCYTE MEMBRANE
PROTEIN 1


(Plasmodium
falciparum)
PF05424
(Duffy_binding)
4 ASN A2352
ALA A2410
GLY A2412
TYR A2411
None
0.94A 1c8lA-2y8dA:
undetectable
1c8lA-2y8dA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE


(Escherichia
coli)
PF03588
(Leu_Phe_trans)
4 PHE A  47
ALA A  41
GLY A  45
TYR A  42
None
1.06A 1c8lA-2z3kA:
undetectable
1c8lA-2z3kA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38)
PF00353
(HemolysinCabind)
4 ASN A 344
ALA A 317
GLY A 319
TYR A 318
None
0.86A 1c8lA-2z8zA:
undetectable
1c8lA-2z8zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6
CYTOCHROME B6-F
COMPLEX SUBUNIT 5


(Nostoc sp. PCC
7120)
PF00033
(Cytochrome_B)
PF02529
(PetG)
4 ASN A  31
ALA G  24
GLY G  20
TYR G  23
None
None
BCR  G 101 (-3.4A)
BCR  G 101 (-3.7A)
1.00A 1c8lA-2zt9A:
undetectable
1c8lA-2zt9A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE


(Sulfurisphaera
tokodaii)
PF07859
(Abhydrolase_3)
4 ASN A 254
ALA A 251
GLY A 249
TYR A 252
None
1.14A 1c8lA-3ailA:
5.5
1c8lA-3ailA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5e MLL8374 PROTEIN

(Mesorhizobium
japonicum)
no annotation 4 ASN A 122
HIS A 198
GLY A 116
TYR A 117
EDO  A 229 (-3.2A)
None
None
EDO  A 232 (-4.6A)
1.12A 1c8lA-3b5eA:
undetectable
1c8lA-3b5eA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans)
PF10282
(Lactonase)
4 ASN A 435
HIS A 136
GLY A 379
TYR A 381
None
0.91A 1c8lA-3bwsA:
undetectable
1c8lA-3bwsA:
19.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM


(Homo sapiens)
PF00343
(Phosphorylase)
6 ASN A 282
PHE A 285
HIS A 571
ALA A 610
GLY A 612
TYR A 613
None
0.78A 1c8lA-3cemA:
67.4
1c8lA-3cemA:
80.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f44 PUTATIVE
MONOOXYGENASE


(Lactobacillus
acidophilus)
PF03992
(ABM)
4 ASN A 173
ALA A 176
GLY A 149
TYR A 171
None
1.12A 1c8lA-3f44A:
undetectable
1c8lA-3f44A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE


(Ruegeria sp.
TM1040)
PF00202
(Aminotran_3)
4 ASN A 126
HIS A 322
ALA A 122
GLY A 299
None
1.13A 1c8lA-3fcrA:
undetectable
1c8lA-3fcrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE


(Ruegeria sp.
TM1040)
PF00202
(Aminotran_3)
4 ASN A 126
HIS A 322
GLY A 299
TYR A 114
None
1.12A 1c8lA-3fcrA:
undetectable
1c8lA-3fcrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7n LIPASE

(Penicillium
expansum)
PF01764
(Lipase_3)
4 ASN A 185
HIS A 131
ALA A 243
GLY A 246
None
1.09A 1c8lA-3g7nA:
2.6
1c8lA-3g7nA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE


(Mesorhizobium
japonicum)
PF00202
(Aminotran_3)
4 ASN A 127
HIS A 323
GLY A 300
TYR A 115
None
1.13A 1c8lA-3gjuA:
undetectable
1c8lA-3gjuA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1


(Saccharomyces
cerevisiae)
PF00012
(HSP70)
4 ASN A 153
PHE A 152
ALA A 155
GLY A  77
None
1.08A 1c8lA-3gl1A:
undetectable
1c8lA-3gl1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I


(Burkholderia
pseudomallei)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 ASN A 290
PHE A 287
ALA A 292
GLY A 276
None
0.83A 1c8lA-3gnqA:
2.8
1c8lA-3gnqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III


(Deinococcus
radiodurans)
PF00202
(Aminotran_3)
4 ASN A 171
ALA A 210
GLY A 212
TYR A 213
None
0.91A 1c8lA-3i4jA:
undetectable
1c8lA-3i4jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7j BETA-LACTAMASE
MB2281C


(Mycobacterium
bovis)
PF00144
(Beta-lactamase)
4 ASN A 198
HIS A 213
GLY A 193
TYR A 192
None
1.14A 1c8lA-3i7jA:
undetectable
1c8lA-3i7jA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE


(Porphyromonas
gingivalis)
no annotation 4 PHE A 269
HIS A 295
ALA A 301
GLY A 302
None
FMT  A 504 ( 4.1A)
None
None
1.04A 1c8lA-3ll7A:
undetectable
1c8lA-3ll7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis)
PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm)
4 ASN A 357
HIS A 348
ALA A 356
GLY A 355
None
ZN  A 999 (-3.2A)
None
None
1.00A 1c8lA-3p24A:
undetectable
1c8lA-3p24A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE


(Helicobacter
pylori)
PF08501
(Shikimate_dh_N)
4 HIS A  15
ALA A 209
GLY A 230
TYR A 210
None
1.02A 1c8lA-3phgA:
2.7
1c8lA-3phgA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT


(Rhodopseudomonas
palustris)
PF00016
(RuBisCO_large)
4 ASN A 192
HIS A 153
ALA A 156
GLY A 159
None
1.11A 1c8lA-3qfwA:
undetectable
1c8lA-3qfwA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj3 CATHEPSIN L-LIKE
PROTEIN


(Tenebrio
molitor)
PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29)
4 ASN A 287
PHE A 299
GLY A 248
TYR A 250
None
1.11A 1c8lA-3qj3A:
undetectable
1c8lA-3qj3A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG


(Saccharomyces
cerevisiae)
PF00012
(HSP70)
4 ASN A 197
PHE A 196
ALA A 199
GLY A 121
None
1.12A 1c8lA-3qmlA:
undetectable
1c8lA-3qmlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyg CO-TYPE NITRILE
HYDRATASE BETA
SUBUNIT


(Pseudomonas
putida)
PF02211
(NHase_beta)
4 ASN B  47
HIS B 147
ALA B 174
GLY B 177
None
1.13A 1c8lA-3qygB:
undetectable
1c8lA-3qygB:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)


(Mycobacterium
tuberculosis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 ASN A   3
ALA A  75
GLY A  73
TYR A  72
None
1.00A 1c8lA-3r44A:
undetectable
1c8lA-3r44A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
4 ASN A 297
HIS A 349
ALA A 298
GLY A 342
None
1.08A 1c8lA-3u4jA:
4.8
1c8lA-3u4jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE


(Acetobacter
aceti)
PF02515
(CoA_transf_3)
4 ASN A  72
ALA A  33
GLY A  36
TYR A  35
None
1.12A 1c8lA-3ubmA:
2.1
1c8lA-3ubmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE


(Aspergillus
fumigatus)
PF01704
(UDPGP)
4 ASN A  75
ALA A  42
GLY A  43
TYR A  39
None
1.13A 1c8lA-4bmaA:
undetectable
1c8lA-4bmaA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae)
PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C)
4 ASN A 591
ALA A 595
GLY A 593
TYR A 560
None
None
None
NAG  A2009 (-4.6A)
1.11A 1c8lA-4d72A:
undetectable
1c8lA-4d72A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h32 HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 ASN A 190
HIS A 180
GLY A 193
TYR A 192
None
1.09A 1c8lA-4h32A:
undetectable
1c8lA-4h32A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7


(Clostridioides
difficile)
PF00877
(NLPC_P60)
PF13702
(Lysozyme_like)
4 ASN A 139
HIS A 155
GLY A 141
TYR A 144
GOL  A 406 ( 3.9A)
None
None
None
1.10A 1c8lA-4hpeA:
undetectable
1c8lA-4hpeA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3m AEROTAXIS TRANSDUCER
AER2


(Pseudomonas
aeruginosa)
no annotation 4 PHE A 130
ALA A 124
GLY A 126
TYR A 125
None
0.96A 1c8lA-4i3mA:
undetectable
1c8lA-4i3mA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ASN A   4
HIS A 393
ALA A 137
GLY A   6
None
1.14A 1c8lA-4jlwA:
undetectable
1c8lA-4jlwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN


(Veillonella
parvula)
PF01497
(Peripla_BP_2)
4 ASN A  69
ALA A 155
GLY A 129
TYR A 153
None
1.12A 1c8lA-4ljsA:
undetectable
1c8lA-4ljsA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE


(Rhizomucor
miehei)
no annotation 4 ASN A 166
PHE A 169
ALA A 165
TYR A 126
None
1.05A 1c8lA-4lypA:
undetectable
1c8lA-4lypA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2


(Streptococcus
pyogenes)
no annotation 4 ASN A 677
PHE A 666
GLY A 645
TYR A 644
None
1.09A 1c8lA-4nuzA:
undetectable
1c8lA-4nuzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5f TYPE III
PANTOTHENATE KINASE


(Burkholderia
thailandensis)
PF03309
(Pan_kinase)
4 ASN A  91
PHE A 139
ALA A  82
GLY A 100
None
None
None
PAU  A 301 (-3.4A)
1.06A 1c8lA-4o5fA:
undetectable
1c8lA-4o5fA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51


(Mus musculus)
PF03281
(Mab-21)
4 ASN A 433
HIS A 391
GLY A 422
TYR A 418
None
1.14A 1c8lA-4oahA:
undetectable
1c8lA-4oahA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtf CHAPERONE PROTEIN
DNAK


(Mycobacterium
tuberculosis)
PF00012
(HSP70)
4 ASN D 123
PHE D 122
ALA D 125
GLY D  74
None
1.14A 1c8lA-4rtfD:
undetectable
1c8lA-4rtfD:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Neisseria
meningitidis)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 ASN A 125
ALA A   4
GLY A 175
TYR A   3
None
1.10A 1c8lA-4rybA:
undetectable
1c8lA-4rybA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii)
PF00144
(Beta-lactamase)
4 ASN A  79
ALA A 251
GLY A  74
TYR A  76
None
1.10A 1c8lA-4u0tA:
undetectable
1c8lA-4u0tA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN


(Agrobacterium
tumefaciens)
PF00884
(Sulfatase)
PF16347
(DUF4976)
4 PHE A  58
ALA A 330
GLY A 347
TYR A 349
None
1.13A 1c8lA-4uphA:
undetectable
1c8lA-4uphA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE


(Burkholderia
cenocepacia)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 PHE A 292
ALA A 265
GLY A 258
TYR A 261
None
0.97A 1c8lA-4wjbA:
undetectable
1c8lA-4wjbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqt RNA CLEAVAGE
STIMULATING FACTOR
(GREA/GFH1 CHIMERIC
PROTEIN GRE-C1)


(Thermus
thermophilus)
PF01272
(GreA_GreB)
PF03449
(GreA_GreB_N)
4 PHE X  33
ALA X  36
GLY X  47
TYR X  48
None
0.99A 1c8lA-4wqtX:
undetectable
1c8lA-4wqtX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN


(Campylobacter
jejuni)
PF02743
(dCache_1)
4 ASN A 265
HIS A 251
ALA A 289
GLY A 292
ACT  A 401 ( 4.3A)
ACT  A 401 (-4.0A)
ACT  A 401 (-3.5A)
None
1.05A 1c8lA-4wy9A:
undetectable
1c8lA-4wy9A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 3


(Drosophila
melanogaster)
PF04084
(ORC2)
PF07034
(ORC3_N)
4 ASN B 484
PHE B 351
GLY C 317
TYR C 320
None
1.05A 1c8lA-4xgcB:
undetectable
1c8lA-4xgcB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV)
4 PHE A 273
HIS A 286
ALA A 276
GLY A 271
None
CU  A 701 (-3.1A)
None
None
1.11A 1c8lA-4z11A:
undetectable
1c8lA-4z11A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgj NITRILE HYDRATASE
BETA SUBUNIT


(Comamonas
testosteroni)
PF02211
(NHase_beta)
4 ASN B  47
HIS B 135
ALA B 162
GLY B 165
None
1.07A 1c8lA-4zgjB:
undetectable
1c8lA-4zgjB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af3 VAPBC49

(Mycobacterium
tuberculosis)
PF04255
(DUF433)
4 ASN A 182
ALA A 181
GLY A 179
TYR A 178
None
0.99A 1c8lA-5af3A:
undetectable
1c8lA-5af3A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN


(Homo sapiens)
PF00012
(HSP70)
4 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.08A 1c8lA-5e84A:
undetectable
1c8lA-5e84A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1


(Arabidopsis
thaliana)
PF03321
(GH3)
4 PHE A 223
HIS A 229
ALA A 221
GLY A 303
None
1.08A 1c8lA-5ecoA:
undetectable
1c8lA-5ecoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens)
PF05450
(Nicastrin)
4 PHE A 448
HIS A 449
ALA A 442
GLY A 366
None
1.08A 1c8lA-5fn4A:
undetectable
1c8lA-5fn4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6


(Homo sapiens)
PF07571
(TAF6_C)
4 HIS J 422
ALA J 378
GLY J 375
TYR J 374
None
1.13A 1c8lA-5furJ:
undetectable
1c8lA-5furJ:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22)
no annotation 4 ASN Y 340
PHE Y 337
HIS Y 427
GLY Y 348
None
1.05A 1c8lA-5gaiY:
undetectable
1c8lA-5gaiY:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghf AMINOTRANSFERASE
CLASS-III


(Ochrobactrum
anthropi)
PF00202
(Aminotran_3)
4 ASN A 167
HIS A 180
ALA A 159
GLY A 153
None
None
None
PMP  A 501 ( 3.7A)
1.14A 1c8lA-5ghfA:
undetectable
1c8lA-5ghfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE


(Caldicellulosiruptor
sp. F32)
PF00150
(Cellulase)
4 ASN A 362
PHE A 372
ALA A 364
GLY A 369
CTT  A 401 (-4.0A)
CTT  A 401 ( 4.5A)
None
None
1.07A 1c8lA-5h4rA:
undetectable
1c8lA-5h4rA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iai SUGAR ABC
TRANSPORTER


(Agrobacterium
tumefaciens)
PF01547
(SBP_bac_1)
4 PHE A 356
HIS A 345
ALA A 353
GLY A 352
None
0.92A 1c8lA-5iaiA:
undetectable
1c8lA-5iaiA:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM


(Homo sapiens)
PF00343
(Phosphorylase)
4 HIS A 571
ALA A 610
GLY A 612
TYR A 613
None
0.72A 1c8lA-5ikpA:
undetectable
1c8lA-5ikpA:
83.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjo UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF08238
(Sel1)
4 ASN A 188
ALA A 185
GLY A 183
TYR A 184
None
1.13A 1c8lA-5jjoA:
undetectable
1c8lA-5jjoA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE


([Candida]
glabrata)
PF00067
(p450)
4 ASN A 307
ALA A 306
GLY A 264
TYR A 266
None
1.07A 1c8lA-5jlcA:
undetectable
1c8lA-5jlcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9h 0940_GH29

(unidentified)
PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos)
4 ASN A 175
ALA A 174
GLY A 172
TYR A 171
None
0.91A 1c8lA-5k9hA:
undetectable
1c8lA-5k9hA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei)
PF00141
(peroxidase)
4 PHE A 728
ALA A 724
GLY A 720
TYR A 719
None
0.99A 1c8lA-5kqiA:
undetectable
1c8lA-5kqiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx4 10.7 KDA SALIVARY
PROTEIN


(Lutzomyia
longipalpis)
no annotation 4 ASN A  13
PHE A  10
ALA A  14
TYR A  79
None
1.11A 1c8lA-5kx4A:
undetectable
1c8lA-5kx4A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus)
PF07859
(Abhydrolase_3)
4 PHE A 185
HIS A 281
ALA A  85
GLY A 213
None
1.02A 1c8lA-5l2pA:
undetectable
1c8lA-5l2pA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878


(Staphylococcus
aureus)
no annotation 4 PHE A 145
ALA A 149
GLY A 189
TYR A 188
None
1.04A 1c8lA-5na4A:
undetectable
1c8lA-5na4A:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK


(Mycoplasma
genitalium)
no annotation 4 ASN A 130
PHE A 129
ALA A 132
GLY A  76
None
1.11A 1c8lA-5obuA:
undetectable
1c8lA-5obuA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obw CHAPERONE PROTEIN
DNAK


(Mycoplasma
genitalium)
no annotation 4 ASN A 130
PHE A 129
ALA A 132
GLY A  76
SO4  A 406 (-4.3A)
GOL  A 410 (-4.8A)
None
None
1.13A 1c8lA-5obwA:
undetectable
1c8lA-5obwA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa)
PF00026
(Asp)
4 ASN A 180
ALA A 324
GLY A 177
TYR A 175
None
1.02A 1c8lA-5pepA:
undetectable
1c8lA-5pepA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyq UNCHARACTERIZED
PROTEIN


(Mycobacterium
tuberculosis)
PF00551
(Formyl_trans_N)
4 HIS A  12
ALA A 140
GLY A 136
TYR A 139
None
None
CL  A 307 (-3.6A)
0FX  A 302 (-3.8A)
1.11A 1c8lA-5vyqA:
undetectable
1c8lA-5vyqA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8x LIPID-A-DISACCHARIDE
SYNTHASE


(Escherichia
coli)
no annotation 4 ASN A 103
PHE A 102
ALA A  99
GLY A  14
None
0.78A 1c8lA-5w8xA:
undetectable
1c8lA-5w8xA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1


(Streptococcus
pyogenes)
PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI)
4 PHE A 351
ALA A 360
GLY A 358
TYR A 359
G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
0.84A 1c8lA-5xblA:
undetectable
1c8lA-5xblA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN


(Electrophorus
electricus)
PF00520
(Ion_trans)
PF06512
(Na_trans_assoc)
4 ASN A 266
PHE A 263
ALA A 373
GLY A 375
None
0.76A 1c8lA-5xsyA:
undetectable
1c8lA-5xsyA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1


(Yarrowia
lipolytica)
no annotation 4 ASN A 428
PHE A 430
ALA A 636
GLY A 639
None
1.13A 1c8lA-5y9dA:
undetectable
1c8lA-5y9dA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3


(Yarrowia
lipolytica)
no annotation 4 ASN A 439
PHE A 441
ALA A 646
GLY A 649
None
1.07A 1c8lA-5ys9A:
undetectable
1c8lA-5ys9A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila)
no annotation 4 PHE A 176
HIS A  93
GLY A 182
TYR A 183
None
1.08A 1c8lA-6b7pA:
undetectable
1c8lA-6b7pA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN


(Cricetulus
griseus)
no annotation 4 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.07A 1c8lA-6eoeA:
undetectable
1c8lA-6eoeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila)
no annotation 4 HIS A 301
ALA A 203
GLY A 201
TYR A 188
None
1.03A 1c8lA-6f74A:
undetectable
1c8lA-6f74A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM


(Streptomyces
maritimus)
no annotation 4 ASN A 375
ALA A 431
GLY A 433
TYR A 432
None
1.05A 1c8lA-6fydA:
undetectable
1c8lA-6fydA:
8.86