SIMILAR PATTERNS OF AMINO ACIDS FOR 1C4D_D_DVAD8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bol PROTEIN
(RIBONUCLEASE RH)

(Rhizopus niveus) 		PF00445
(Ribonuclease_T2) 		3 TRP A  91
VAL A 100
TRP A 102
 None
 1.26A 1c4dC-1bolA:
undetectable
1c4dD-1bolA:
undetectable		 1c4dC-1bolA:
10.87
1c4dD-1bolA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3a FLAVOCETIN-A: ALPHA
SUBUNIT

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP A  69
VAL A  42
TRP A  25
 None
 1.13A 1c4dC-1c3aA:
undetectable
1c4dD-1c3aA:
undetectable		 1c4dC-1c3aA:
8.55
1c4dD-1c3aA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3a FLAVOCETIN-A: ALPHA
SUBUNIT

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP A  69
VAL A 128
TRP A  25
 None
 1.33A 1c4dC-1c3aA:
undetectable
1c4dD-1c3aA:
undetectable		 1c4dC-1c3aA:
8.55
1c4dD-1c3aA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbn PROTEIN
(LEUKOAGGLUTININ)

(Maackia
amurensis) 		PF00139
(Lectin_legB) 		3 TRP A 161
VAL A 168
TRP A 163
 None
 1.33A 1c4dC-1dbnA:
undetectable
1c4dD-1dbnA:
undetectable		 1c4dC-1dbnA:
6.67
1c4dD-1dbnA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dv8 ASIALOGLYCOPROTEIN
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 210
VAL A 189
TRP A 174
 None
 1.26A 1c4dC-1dv8A:
undetectable
1c4dD-1dv8A:
undetectable		 1c4dC-1dv8A:
15.94
1c4dD-1dv8A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dv8 ASIALOGLYCOPROTEIN
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 210
VAL A 275
TRP A 174
 None
 1.29A 1c4dC-1dv8A:
undetectable
1c4dD-1dv8A:
undetectable		 1c4dC-1dv8A:
15.94
1c4dD-1dv8A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A

(Robinia
pseudoacacia) 		PF00139
(Lectin_legB) 		3 TRP A 156
VAL A 163
TRP A 158
 None
 1.30A 1c4dC-1fnzA:
undetectable
1c4dD-1fnzA:
undetectable		 1c4dC-1fnzA:
4.64
1c4dD-1fnzA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1s P-SELECTIN

(Homo sapiens) 		PF00008
(EGF)
PF00059
(Lectin_C) 		3 TRP A  50
VAL A  27
TRP A  12
 None
MRD  A 807 ( 4.7A)
None
 1.26A 1c4dC-1g1sA:
undetectable
1c4dD-1g1sA:
undetectable		 1c4dC-1g1sA:
9.00
1c4dD-1g1sA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz2 OVOCLEIDIN-17

(Gallus gallus) 		PF00059
(Lectin_C) 		3 TRP A  76
VAL A 137
TRP A  26
 None
 1.32A 1c4dC-1gz2A:
undetectable
1c4dD-1gz2A:
undetectable		 1c4dC-1gz2A:
13.41
1c4dD-1gz2A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A  75
VAL A 481
TRP A 483
 None
 0.95A 1c4dC-1hfuA:
undetectable
1c4dD-1hfuA:
undetectable		 1c4dC-1hfuA:
2.20
1c4dD-1hfuA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 483
VAL A 481
TRP A  75
 None
 1.10A 1c4dC-1hfuA:
undetectable
1c4dD-1hfuA:
undetectable		 1c4dC-1hfuA:
2.20
1c4dD-1hfuA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv6 ALGINATE LYASE

(Sphingomonas
sp.) 		PF05426
(Alginate_lyase) 		3 TRP A 195
VAL A 139
TRP A 141
 None
 1.31A 1c4dC-1hv6A:
undetectable
1c4dD-1hv6A:
undetectable		 1c4dC-1hv6A:
4.23
1c4dD-1hv6A:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijk BOTROCETIN

(Bothrops
jararaca) 		PF00059
(Lectin_C) 		3 TRP B  68
VAL B  40
TRP B  23
 None
 1.28A 1c4dC-1ijkB:
undetectable
1c4dD-1ijkB:
undetectable		 1c4dC-1ijkB:
12.20
1c4dD-1ijkB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixx COAGULATION FACTORS
IX/X-BINDING PROTEIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP A  67
VAL A  40
TRP A  23
 None
 1.20A 1c4dC-1ixxA:
undetectable
1c4dD-1ixxA:
undetectable		 1c4dC-1ixxA:
11.49
1c4dD-1ixxA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixx COAGULATION FACTORS
IX/X-BINDING PROTEIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP A  67
VAL A 126
TRP A  23
 None
 1.33A 1c4dC-1ixxA:
undetectable
1c4dD-1ixxA:
undetectable		 1c4dC-1ixxA:
11.49
1c4dD-1ixxA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9j MDC-SIGN2 TYPE I
ISOFORM

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 327
VAL A 304
TRP A 289
 None
 1.34A 1c4dC-1k9jA:
undetectable
1c4dD-1k9jA:
undetectable		 1c4dC-1k9jA:
18.18
1c4dD-1k9jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlf REGULATORY PROTEIN
REPA

(Escherichia
coli) 		PF13481
(AAA_25) 		3 TRP A 223
VAL A 264
TRP A 251
 None
 1.03A 1c4dC-1nlfA:
undetectable
1c4dD-1nlfA:
undetectable		 1c4dC-1nlfA:
9.68
1c4dD-1nlfA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlf REGULATORY PROTEIN
REPA

(Escherichia
coli) 		PF13481
(AAA_25) 		3 TRP A 251
VAL A 264
TRP A 223
 None
 0.98A 1c4dC-1nlfA:
undetectable
1c4dD-1nlfA:
undetectable		 1c4dC-1nlfA:
9.68
1c4dD-1nlfA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oij PUTATIVE
ALKYLSULFATASE ATSK

(Pseudomonas
putida) 		PF02668
(TauD) 		3 TRP C 249
VAL C 136
TRP C 247
 None
 1.33A 1c4dC-1oijC:
undetectable
1c4dD-1oijC:
undetectable		 1c4dC-1oijC:
4.84
1c4dD-1oijC:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz7 ECHICETIN B-CHAIN

(Echis carinatus) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B  40
TRP B  23
 None
 1.34A 1c4dC-1oz7B:
undetectable
1c4dD-1oz7B:
undetectable		 1c4dC-1oz7B:
26.67
1c4dD-1oz7B:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdd LITHOSTATHINE

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A  77
VAL A  51
TRP A  35
 None
 1.28A 1c4dC-1qddA:
undetectable
1c4dD-1qddA:
undetectable		 1c4dC-1qddA:
17.54
1c4dD-1qddA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP2)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 TRP 2 177
VAL 2  82
TRP 2 105
 None
 1.23A 1c4dC-1qgc2:
undetectable
1c4dD-1qgc2:
undetectable		 1c4dC-1qgc2:
8.05
1c4dD-1qgc2:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qot CHITIN BINDING
LECTIN, UEA-II

(Ulex europaeus) 		PF00139
(Lectin_legB) 		3 TRP A 160
VAL A 167
TRP A 162
 None
 1.33A 1c4dC-1qotA:
undetectable
1c4dD-1qotA:
undetectable		 1c4dC-1qotA:
5.58
1c4dD-1qotA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sl6 C-TYPE LECTIN
DC-SIGNR

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 327
VAL A 304
TRP A 289
 None
 1.33A 1c4dC-1sl6A:
undetectable
1c4dD-1sl6A:
undetectable		 1c4dC-1sl6A:
10.48
1c4dD-1sl6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o BOTROCETIN

(Bothrops
jararaca) 		PF00059
(Lectin_C) 		3 TRP B 265
VAL B 240
TRP B 223
 None
 1.15A 1c4dC-1u0oB:
undetectable
1c4dD-1u0oB:
undetectable		 1c4dC-1u0oB:
9.17
1c4dD-1u0oB:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o BOTROCETIN

(Bothrops
jararaca) 		PF00059
(Lectin_C) 		3 TRP B 265
VAL B 320
TRP B 223
 None
 1.30A 1c4dC-1u0oB:
undetectable
1c4dD-1u0oB:
undetectable		 1c4dC-1u0oB:
9.17
1c4dD-1u0oB:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukm EMS16 A CHAIN

(Echis
multisquamatus) 		PF00059
(Lectin_C) 		3 TRP A  69
VAL A  42
TRP A  25
 None
 1.25A 1c4dC-1ukmA:
undetectable
1c4dD-1ukmA:
undetectable		 1c4dC-1ukmA:
9.91
1c4dD-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukm EMS16 A CHAIN

(Echis
multisquamatus) 		PF00059
(Lectin_C) 		3 TRP A  69
VAL A 128
TRP A  25
 None
 1.34A 1c4dC-1ukmA:
undetectable
1c4dD-1ukmA:
undetectable		 1c4dC-1ukmA:
9.91
1c4dD-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukm EMS16 B CHAIN

(Echis
multisquamatus) 		PF00059
(Lectin_C) 		3 TRP B  64
VAL B 119
TRP B  22
 None
 1.30A 1c4dC-1ukmB:
undetectable
1c4dD-1ukmB:
undetectable		 1c4dC-1ukmB:
23.33
1c4dD-1ukmB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umr CONVULXIN BETA

(Crotalus
durissus) 		PF00059
(Lectin_C) 		3 TRP C 267
VAL C 242
TRP C 225
 None
 1.22A 1c4dC-1umrC:
undetectable
1c4dD-1umrC:
undetectable		 1c4dC-1umrC:
10.19
1c4dD-1umrC:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umr CONVULXIN BETA

(Crotalus
durissus) 		PF00059
(Lectin_C) 		3 TRP C 267
VAL C 320
TRP C 225
 None
 1.34A 1c4dC-1umrC:
undetectable
1c4dD-1umrC:
undetectable		 1c4dC-1umrC:
10.19
1c4dD-1umrC:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4l MUCROCETIN BETA
CHAIN

(Protobothrops
mucrosquamatus) 		PF00059
(Lectin_C) 		3 TRP B 267
VAL B 242
TRP B 225
 None
 1.16A 1c4dC-1v4lB:
undetectable
1c4dD-1v4lB:
undetectable		 1c4dC-1v4lB:
8.00
1c4dD-1v4lB:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmy LECTIN CEL-I,
N-ACETYL-D-GALACTOSA
MINE-SPECIFIC C-TYPE

(Cucumaria
echinata) 		PF00059
(Lectin_C) 		3 TRP A  72
VAL A  46
TRP A  24
 None
 1.31A 1c4dC-1wmyA:
undetectable
1c4dD-1wmyA:
undetectable		 1c4dC-1wmyA:
17.02
1c4dD-1wmyA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wt9 ANTICOAGULANT
PROTEIN-B

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B  40
TRP B  23
 None
 1.16A 1c4dC-1wt9B:
undetectable
1c4dD-1wt9B:
undetectable		 1c4dC-1wt9B:
13.75
1c4dD-1wt9B:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wt9 ANTICOAGULANT
PROTEIN-B

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B 118
TRP B  23
 None
 1.29A 1c4dC-1wt9B:
undetectable
1c4dD-1wt9B:
undetectable		 1c4dC-1wt9B:
13.75
1c4dD-1wt9B:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2w COAGULATION FACTOR
IX/FACTOR X-BINDING
PROTEIN B CHAIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B  40
TRP B  23
 None
 1.14A 1c4dC-1x2wB:
undetectable
1c4dD-1x2wB:
undetectable		 1c4dC-1x2wB:
13.75
1c4dD-1x2wB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2w COAGULATION FACTOR
IX/FACTOR X-BINDING
PROTEIN B CHAIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B 118
TRP B  23
 None
 1.33A 1c4dC-1x2wB:
undetectable
1c4dD-1x2wB:
undetectable		 1c4dC-1x2wB:
13.75
1c4dD-1x2wB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2w COAGULATION FACTOR
IX/X-BINDING PROTEIN
A CHAIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		3 TRP A  67
VAL A  40
TRP A  23
 None
 1.23A 1c4dC-1x2wA:
undetectable
1c4dD-1x2wA:
undetectable		 1c4dC-1x2wA:
10.43
1c4dD-1x2wA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y17 ANTICOAGULANT
PROTEIN A

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 TRP A  67
VAL A  40
TRP A  23
 None
 1.26A 1c4dC-1y17A:
undetectable
1c4dD-1y17A:
undetectable		 1c4dC-1y17A:
9.57
1c4dD-1y17A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y17 ANTICOAGULANT
PROTEIN A

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 TRP A  67
VAL A 126
TRP A  23
 None
 1.32A 1c4dC-1y17A:
undetectable
1c4dD-1y17A:
undetectable		 1c4dC-1y17A:
9.57
1c4dD-1y17A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 2

(Daboia
siamensis) 		PF00059
(Lectin_C) 		3 TRP B  67
VAL B  40
TRP B  23
 None
 1.22A 1c4dC-2e3xB:
undetectable
1c4dD-2e3xB:
undetectable		 1c4dC-2e3xB:
10.00
1c4dD-2e3xB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP B 220
VAL B 199
TRP B 184
 None
 1.29A 1c4dC-2h2tB:
undetectable
1c4dD-2h2tB:
undetectable		 1c4dC-2h2tB:
4.38
1c4dD-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP B 220
VAL B 281
TRP B 184
 None
 1.31A 1c4dC-2h2tB:
undetectable
1c4dD-2h2tB:
undetectable		 1c4dC-2h2tB:
4.38
1c4dD-2h2tB:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 TRP A  92
VAL A 135
TRP A 133
 None
 1.05A 1c4dC-2h6eA:
undetectable
1c4dD-2h6eA:
undetectable		 1c4dC-2h6eA:
5.63
1c4dD-2h6eA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 TRP A 133
VAL A  87
TRP A  92
 None
 1.15A 1c4dC-2h6eA:
undetectable
1c4dD-2h6eA:
undetectable		 1c4dC-2h6eA:
5.63
1c4dD-2h6eA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		3 TRP A 248
VAL A 145
TRP A 496
 None
 1.08A 1c4dC-2qqpA:
undetectable
1c4dD-2qqpA:
undetectable		 1c4dC-2qqpA:
2.16
1c4dD-2qqpA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		3 TRP A 496
VAL A 145
TRP A 248
 None
 1.34A 1c4dC-2qqpA:
undetectable
1c4dD-2qqpA:
undetectable		 1c4dC-2qqpA:
2.16
1c4dD-2qqpA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 TRP F 368
VAL F 362
TRP F 596
 None
 1.35A 1c4dC-2v2fF:
undetectable
1c4dD-2v2fF:
undetectable		 1c4dC-2v2fF:
3.92
1c4dD-2v2fF:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrp AGGRETIN BETA CHAIN

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B  40
TRP B  23
 None
 1.13A 1c4dC-2vrpB:
undetectable
1c4dD-2vrpB:
undetectable		 1c4dC-2vrpB:
12.50
1c4dD-2vrpB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrp AGGRETIN BETA CHAIN

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B 118
TRP B  23
 None
 1.33A 1c4dC-2vrpB:
undetectable
1c4dD-2vrpB:
undetectable		 1c4dC-2vrpB:
12.50
1c4dD-2vrpB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 TRP A 461
VAL A 321
TRP A 599
 None
 0.82A 1c4dC-2wdaA:
undetectable
1c4dD-2wdaA:
undetectable		 1c4dC-2wdaA:
2.06
1c4dD-2wdaA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bx4 AGGRETIN BETA CHAIN

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B  40
TRP B  23
 None
 1.18A 1c4dC-3bx4B:
undetectable
1c4dD-3bx4B:
undetectable		 1c4dC-3bx4B:
9.71
1c4dD-3bx4B:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bx4 AGGRETIN BETA CHAIN

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 TRP B  65
VAL B 118
TRP B  23
 None
 1.34A 1c4dC-3bx4B:
undetectable
1c4dD-3bx4B:
undetectable		 1c4dC-3bx4B:
9.71
1c4dD-3bx4B:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpr RHODOCETIN SUBUNIT
ALPHA

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 TRP A1067
VAL A1040
TRP A1023
 None
 1.34A 1c4dC-3gprA:
undetectable
1c4dD-3gprA:
undetectable		 1c4dC-3gprA:
7.52
1c4dD-3gprA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		3 TRP A 171
VAL A 256
TRP A 175
 None
 1.20A 1c4dC-3hf1A:
undetectable
1c4dD-3hf1A:
undetectable		 1c4dC-3hf1A:
2.85
1c4dD-3hf1A:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
horikoshii) 		PF07969
(Amidohydro_3) 		3 TRP X 385
VAL X 388
TRP X 386
 None
 0.95A 1c4dC-3ighX:
undetectable
1c4dD-3ighX:
undetectable		 1c4dC-3ighX:
3.32
1c4dD-3ighX:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN

(Candidatus
Korarchaeum
cryptofilum) 		PF13298
(LigD_N) 		3 TRP A  75
VAL A  72
TRP A  16
 None
 1.33A 1c4dC-3ta7A:
undetectable
1c4dD-3ta7A:
undetectable		 1c4dC-3ta7A:
10.39
1c4dD-3ta7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubu AGGLUCETIN SUBUNIT
ALPHA-1

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 TRP A  67
VAL A  42
TRP A  25
 None
 1.23A 1c4dC-3ubuA:
undetectable
1c4dD-3ubuA:
undetectable		 1c4dC-3ubuA:
9.23
1c4dD-3ubuA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubu AGGLUCETIN SUBUNIT
BETA-2

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 TRP B  67
VAL B  42
TRP B  25
 None
 1.31A 1c4dC-3ubuB:
undetectable
1c4dD-3ubuB:
undetectable		 1c4dC-3ubuB:
9.17
1c4dD-3ubuB:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwk SNACLEC RHODOCYTIN
SUBUNIT ALPHA

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 TRP A  71
VAL A 130
TRP A  26
 None
 1.31A 1c4dC-3wwkA:
undetectable
1c4dD-3wwkA:
undetectable		 1c4dC-3wwkA:
8.09
1c4dD-3wwkA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9f CD209 ANTIGEN-LIKE
PROTEIN B

(Mus musculus) 		PF00059
(Lectin_C) 		3 TRP A 253
VAL A 231
TRP A 216
 None
 1.25A 1c4dC-4c9fA:
undetectable
1c4dD-4c9fA:
undetectable		 1c4dC-4c9fA:
18.37
1c4dD-4c9fA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4caj CD209 ANTIGEN-LIKE
PROTEIN B

(Mus musculus) 		PF00059
(Lectin_C) 		3 TRP A 253
VAL A 231
TRP A 216
 None
 1.30A 1c4dC-4cajA:
undetectable
1c4dD-4cajA:
undetectable		 1c4dC-4cajA:
14.13
1c4dD-4cajA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica) 		PF13434
(K_oxygenase) 		3 TRP A  91
VAL A  96
TRP A 104
 None
 1.31A 1c4dC-4d7eA:
undetectable
1c4dD-4d7eA:
undetectable		 1c4dC-4d7eA:
4.17
1c4dD-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica) 		PF13434
(K_oxygenase) 		3 TRP A 104
VAL A  96
TRP A  91
 None
 1.13A 1c4dC-4d7eA:
undetectable
1c4dD-4d7eA:
undetectable		 1c4dC-4d7eA:
4.17
1c4dD-4d7eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyz CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES

(Ruminococcus
flavefaciens) 		no annotation 3 TRP A 194
VAL A 163
TRP A 161
 None
 1.09A 1c4dC-4eyzA:
undetectable
1c4dD-4eyzA:
undetectable		 1c4dC-4eyzA:
9.09
1c4dD-4eyzA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6p LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 220
VAL A 199
TRP A 184
 None
 1.28A 1c4dC-4j6pA:
undetectable
1c4dD-4j6pA:
undetectable		 1c4dC-4j6pA:
10.00
1c4dD-4j6pA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6p LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 220
VAL A 281
TRP A 184
 None
 1.35A 1c4dC-4j6pA:
undetectable
1c4dD-4j6pA:
undetectable		 1c4dC-4j6pA:
10.00
1c4dD-4j6pA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome) 		PF00150
(Cellulase) 		3 TRP A  51
VAL A  44
TRP A  46
 None
 1.18A 1c4dC-4m1rA:
undetectable
1c4dD-4m1rA:
undetectable		 1c4dC-4m1rA:
4.56
1c4dD-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		3 TRP B 153
VAL B 155
TRP B 157
 K  B 605 ( 4.4A)
None
None
 1.34A 1c4dC-4mbgB:
undetectable
1c4dD-4mbgB:
undetectable		 1c4dC-4mbgB:
7.50
1c4dD-4mbgB:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		3 TRP A 379
VAL A 356
TRP A 339
 None
NA  A 501 ( 4.9A)
None
 1.12A 1c4dC-4nz5A:
undetectable
1c4dD-4nz5A:
undetectable		 1c4dC-4nz5A:
3.54
1c4dD-4nz5A:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o01 BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		3 TRP A 394
VAL A 388
TRP A 412
 None
 1.30A 1c4dC-4o01A:
undetectable
1c4dD-4o01A:
undetectable		 1c4dC-4o01A:
4.05
1c4dD-4o01A:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		3 TRP A 204
VAL A 221
TRP A 227
 None
 0.99A 1c4dC-4rjzA:
undetectable
1c4dD-4rjzA:
undetectable		 1c4dC-4rjzA:
5.73
1c4dD-4rjzA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u36 SEED LECTIN

(Vatairea
macrocarpa) 		PF00139
(Lectin_legB) 		3 TRP A 153
VAL A 160
TRP A 155
 None
 1.34A 1c4dC-4u36A:
undetectable
1c4dD-4u36A:
undetectable		 1c4dC-4u36A:
5.47
1c4dD-4u36A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uac CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-)

([Eubacterium]
rectale) 		PF13416
(SBP_bac_8) 		3 TRP A 193
VAL A 372
TRP A 159
 ACR  A 501 (-3.1A)
PEG  A 502 (-4.4A)
None
 1.26A 1c4dC-4uacA:
undetectable
1c4dD-4uacA:
undetectable		 1c4dC-4uacA:
2.95
1c4dD-4uacA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w82 FATTY ACID SYNTHASE

(Homo sapiens) 		PF00107
(ADH_zinc_N) 		3 TRP A1811
VAL A1613
TRP A1634
 None
 1.20A 1c4dC-4w82A:
undetectable
1c4dD-4w82A:
undetectable		 1c4dC-4w82A:
3.58
1c4dD-4w82A:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xga OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF07244
(POTRA) 		3 TRP B 206
VAL B 208
TRP B 205
 None
 1.34A 1c4dC-4xgaB:
undetectable
1c4dD-4xgaB:
undetectable		 1c4dC-4xgaB:
5.08
1c4dD-4xgaB:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		3 TRP C 168
VAL C 195
TRP C  66
 None
 0.99A 1c4dC-4yfaC:
undetectable
1c4dD-4yfaC:
undetectable		 1c4dC-4yfaC:
3.66
1c4dD-4yfaC:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN

(Toxoplasma
gondii) 		PF02430
(AMA-1)
PF07974
(EGF_2) 		3 TRP A 407
VAL A 409
TRP A 457
 None
 1.15A 1c4dC-4z81A:
undetectable
1c4dD-4z81A:
undetectable		 1c4dC-4z81A:
2.82
1c4dD-4z81A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao5 C-TYPE MANNOSE
RECEPTOR 2

(Homo sapiens) 		PF00040
(fn2)
PF00059
(Lectin_C) 		3 TRP A 297
VAL A 358
TRP A 259
 None
 1.34A 1c4dC-5ao5A:
undetectable
1c4dD-5ao5A:
undetectable		 1c4dC-5ao5A:
3.25
1c4dD-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao5 C-TYPE MANNOSE
RECEPTOR 2

(Homo sapiens) 		PF00040
(fn2)
PF00059
(Lectin_C) 		3 TRP A 441
VAL A 418
TRP A 403
 None
 1.31A 1c4dC-5ao5A:
undetectable
1c4dD-5ao5A:
undetectable		 1c4dC-5ao5A:
3.25
1c4dD-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buv PUTATIVE EPIMERASE

(Yersinia
enterocolitica) 		PF00908
(dTDP_sugar_isom) 		3 TRP A 149
VAL A  58
TRP A 156
 None
 1.06A 1c4dC-5buvA:
undetectable
1c4dD-5buvA:
undetectable		 1c4dC-5buvA:
4.49
1c4dD-5buvA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 TRP B 266
VAL B 261
TRP B 426
 None
 1.29A 1c4dC-5c24B:
undetectable
1c4dD-5c24B:
undetectable		 1c4dC-5c24B:
3.19
1c4dD-5c24B:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 TRP A 201
VAL A 295
TRP A 402
 None
 1.29A 1c4dC-5c5vA:
undetectable
1c4dD-5c5vA:
undetectable		 1c4dC-5c5vA:
3.46
1c4dD-5c5vA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 TRP A 402
VAL A 295
TRP A 201
 None
 1.31A 1c4dC-5c5vA:
undetectable
1c4dD-5c5vA:
undetectable		 1c4dC-5c5vA:
3.46
1c4dD-5c5vA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 TRP A 201
VAL A 295
TRP A 402
 None
 1.26A 1c4dC-5cuyA:
undetectable
1c4dD-5cuyA:
undetectable		 1c4dC-5cuyA:
8.93
1c4dD-5cuyA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 TRP A 402
VAL A 295
TRP A 201
 None
 1.30A 1c4dC-5cuyA:
undetectable
1c4dD-5cuyA:
undetectable		 1c4dC-5cuyA:
8.93
1c4dD-5cuyA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		3 TRP A 499
VAL A 441
TRP A 428
 None
 1.26A 1c4dC-5d39A:
undetectable
1c4dD-5d39A:
undetectable		 1c4dC-5d39A:
3.30
1c4dD-5d39A:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 3 TRP A 244
VAL A 248
TRP A 255
 None
 1.04A 1c4dC-5f75A:
undetectable
1c4dD-5f75A:
undetectable		 1c4dC-5f75A:
4.94
1c4dD-5f75A:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 3 TRP A 255
VAL A 248
TRP A 244
 None
 1.09A 1c4dC-5f75A:
undetectable
1c4dD-5f75A:
undetectable		 1c4dC-5f75A:
4.94
1c4dD-5f75A:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome) 		PF00150
(Cellulase) 		3 TRP A  63
VAL A  56
TRP A  58
 None
 1.12A 1c4dC-5i2uA:
undetectable
1c4dD-5i2uA:
undetectable		 1c4dC-5i2uA:
5.51
1c4dD-5i2uA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		3 TRP A  78
VAL A  71
TRP A  73
 None
 1.08A 1c4dC-5ihsA:
undetectable
1c4dD-5ihsA:
undetectable		 1c4dC-5ihsA:
4.71
1c4dD-5ihsA:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpv ASIALOGLYCOPROTEIN
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 210
VAL A 189
TRP A 174
 None
 1.23A 1c4dC-5jpvA:
undetectable
1c4dD-5jpvA:
undetectable		 1c4dC-5jpvA:
12.82
1c4dD-5jpvA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpv ASIALOGLYCOPROTEIN
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 210
VAL A 275
TRP A 174
 None
 1.28A 1c4dC-5jpvA:
undetectable
1c4dD-5jpvA:
undetectable		 1c4dC-5jpvA:
12.82
1c4dD-5jpvA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		3 TRP A 711
VAL A 630
TRP A 693
 None
 0.93A 1c4dC-5jrlA:
undetectable
1c4dD-5jrlA:
undetectable		 1c4dC-5jrlA:
2.53
1c4dD-5jrlA:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx7 PENTALENENE SYNTHASE

(Streptomyces
clavuligerus) 		no annotation 3 TRP A 126
VAL A 103
TRP A 145
 None
 1.33A 1c4dC-5nx7A:
undetectable
1c4dD-5nx7A:
undetectable		 1c4dC-5nx7A:
14.12
1c4dD-5nx7A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 3 TRP A 244
VAL A 248
TRP A 255
 None
 1.03A 1c4dC-5oexA:
undetectable
1c4dD-5oexA:
undetectable		 1c4dC-5oexA:
6.63
1c4dD-5oexA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 3 TRP A 255
VAL A 248
TRP A 244
 None
 1.10A 1c4dC-5oexA:
undetectable
1c4dD-5oexA:
undetectable		 1c4dC-5oexA:
6.63
1c4dD-5oexA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		3 TRP A  48
VAL A  91
TRP A  45
 None
None
GPE  A 402 (-3.2A)
 1.16A 1c4dC-5t1pA:
undetectable
1c4dD-5t1pA:
undetectable		 1c4dC-5t1pA:
5.60
1c4dD-5t1pA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc1 L-SELECTIN

(Homo sapiens) 		PF00008
(EGF)
PF00059
(Lectin_C) 		3 TRP A  50
VAL A  27
TRP A  12
 None
 1.24A 1c4dC-5vc1A:
undetectable
1c4dD-5vc1A:
undetectable		 1c4dC-5vc1A:
5.26
1c4dD-5vc1A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 3 TRP A 348
VAL A 361
TRP A 358
 None
 1.34A 1c4dC-6byxA:
undetectable
1c4dD-6byxA:
undetectable		 1c4dC-6byxA:
undetectable
1c4dD-6byxA:
undetectable