SIMILAR PATTERNS OF AMINO ACIDS FOR 1C4D_D_DVAD6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)

(Homo sapiens;
Mus musculus) 		no annotation 3 TRP L  35
ALA L  50
VAL L  48
 None
 0.92A 1c4dC-1bbjL:
undetectable
1c4dD-1bbjL:
undetectable		 1c4dC-1bbjL:
7.10
1c4dD-1bbjL:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehw NUCLEOSIDE
DIPHOSPHATE KINASE

(Homo sapiens) 		PF00334
(NDK) 		3 TRP A  78
ALA A  75
VAL A   9
 None
 0.90A 1c4dC-1ehwA:
undetectable
1c4dD-1ehwA:
undetectable		 1c4dC-1ehwA:
10.66
1c4dD-1ehwA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyv N-UTILIZING
SUBSTANCE PROTEIN B
HOMOLOG

(Mycobacterium
tuberculosis) 		PF01029
(NusB) 		3 TRP A  98
ALA A  32
VAL A  62
 None
 0.93A 1c4dC-1eyvA:
undetectable
1c4dD-1eyvA:
undetectable		 1c4dC-1eyvA:
7.09
1c4dD-1eyvA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 TRP A  61
ALA A  58
VAL A  40
 None
 0.87A 1c4dC-1h0hA:
undetectable
1c4dD-1h0hA:
undetectable		 1c4dC-1h0hA:
1.57
1c4dD-1h0hA:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdl CYTOCHROME C2, ISO-2

(Rhodospirillum
centenum) 		PF00034
(Cytochrom_C) 		3 TRP A  63
ALA A  32
VAL A  36
 HEM  A 500 (-4.1A)
None
None
 0.84A 1c4dC-1jdlA:
undetectable
1c4dD-1jdlA:
undetectable		 1c4dC-1jdlA:
7.92
1c4dD-1jdlA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 TRP A  80
ALA A  75
VAL A  68
 None
 0.87A 1c4dC-1jedA:
undetectable
1c4dD-1jedA:
undetectable		 1c4dC-1jedA:
4.23
1c4dD-1jedA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 858
ALA A 854
VAL A 880
 None
 0.73A 1c4dC-1kcwA:
undetectable
1c4dD-1kcwA:
undetectable		 1c4dC-1kcwA:
2.18
1c4dD-1kcwA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n31 L-CYSTEINE/CYSTINE
LYASE C-DES

(Synechocystis
sp. PCC 6714) 		PF00266
(Aminotran_5) 		3 TRP A 313
ALA A 332
VAL A 335
 None
 0.81A 1c4dC-1n31A:
undetectable
1c4dD-1n31A:
undetectable		 1c4dC-1n31A:
4.98
1c4dD-1n31A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 TRP A  79
ALA A  75
VAL A 109
 None
 0.82A 1c4dC-1nxuA:
undetectable
1c4dD-1nxuA:
undetectable		 1c4dC-1nxuA:
2.72
1c4dD-1nxuA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 TRP A  15
ALA A 241
VAL A  12
 None
 0.87A 1c4dC-1qfcA:
undetectable
1c4dD-1qfcA:
undetectable		 1c4dC-1qfcA:
5.00
1c4dD-1qfcA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnx VES V 5

(Vespula
vulgaris) 		PF00188
(CAP) 		3 TRP A  90
ALA A 114
VAL A 186
 None
 0.83A 1c4dC-1qnxA:
undetectable
1c4dD-1qnxA:
undetectable		 1c4dC-1qnxA:
4.31
1c4dD-1qnxA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 TRP A 217
ALA A 132
VAL A 549
 None
FAD  A 605 (-3.3A)
None
 0.75A 1c4dC-1qo8A:
undetectable
1c4dD-1qo8A:
undetectable		 1c4dC-1qo8A:
2.95
1c4dD-1qo8A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 TRP A  80
ALA A  75
VAL A  68
 None
 0.88A 1c4dC-1r6xA:
undetectable
1c4dD-1r6xA:
undetectable		 1c4dC-1r6xA:
9.09
1c4dD-1r6xA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		3 TRP A 180
ALA A 154
VAL A 178
 None
 0.93A 1c4dC-1v9cA:
undetectable
1c4dD-1v9cA:
undetectable		 1c4dC-1v9cA:
7.83
1c4dD-1v9cA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfi NUCLEAR DISTRIBUTION
GENE C HOMOLOG

(Mus musculus) 		PF04969
(CS) 		3 TRP A  71
ALA A  22
VAL A  81
 None
 0.91A 1c4dC-1wfiA:
undetectable
1c4dD-1wfiA:
undetectable		 1c4dC-1wfiA:
11.34
1c4dD-1wfiA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj2 HYPOTHETICAL UPF0301
PROTEIN VC0467

(Vibrio cholerae) 		PF02622
(DUF179) 		3 TRP A 179
ALA A  54
VAL A  36
 None
 0.90A 1c4dC-2aj2A:
undetectable
1c4dD-2aj2A:
undetectable		 1c4dC-2aj2A:
8.19
1c4dD-2aj2A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		3 TRP X  13
ALA X 239
VAL X  10
 None
 0.77A 1c4dC-2bq8X:
undetectable
1c4dD-2bq8X:
undetectable		 1c4dC-2bq8X:
6.11
1c4dD-2bq8X:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cr0 NUCLEAR MIGRATION
PROTEIN NUDC

(Mus musculus) 		PF04969
(CS) 		3 TRP A  81
ALA A  32
VAL A  91
 None
 0.90A 1c4dC-2cr0A:
undetectable
1c4dD-2cr0A:
undetectable		 1c4dC-2cr0A:
9.09
1c4dD-2cr0A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in5 HYPOTHETICAL
LIPOPROTEIN YMCC

(Escherichia
coli) 		PF11102
(YjbF) 		3 TRP A 150
ALA A 172
VAL A 169
 None
 0.85A 1c4dC-2in5A:
undetectable
1c4dD-2in5A:
undetectable		 1c4dC-2in5A:
8.39
1c4dD-2in5A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		3 TRP A  72
ALA A 181
VAL A 187
 None
 0.90A 1c4dC-2j6lA:
undetectable
1c4dD-2j6lA:
undetectable		 1c4dC-2j6lA:
3.50
1c4dD-2j6lA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		3 TRP A  70
ALA A 179
VAL A 185
 None
 0.93A 1c4dC-2jg7A:
undetectable
1c4dD-2jg7A:
undetectable		 1c4dC-2jg7A:
2.68
1c4dD-2jg7A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jv8 UNCHARACTERIZED
PROTEIN NE1242

(Nitrosomonas
europaea) 		no annotation 3 TRP A  39
ALA A  34
VAL A  31
 None
 0.91A 1c4dC-2jv8A:
undetectable
1c4dD-2jv8A:
undetectable		 1c4dC-2jv8A:
13.43
1c4dD-2jv8A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		3 TRP A  90
ALA A  93
VAL A  21
 TRP  A  90 ( 0.5A)
ALA  A  93 ( 0.0A)
VAL  A  21 ( 0.6A)
 0.89A 1c4dC-2ogsA:
undetectable
1c4dD-2ogsA:
undetectable		 1c4dC-2ogsA:
2.58
1c4dD-2ogsA:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyo UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Deinococcus
geothermalis) 		PF02627
(CMD) 		3 TRP A 118
ALA A 115
VAL A  83
 None
 0.91A 1c4dC-2oyoA:
undetectable
1c4dD-2oyoA:
undetectable		 1c4dC-2oyoA:
9.71
1c4dD-2oyoA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE

(Agrobacterium
fabrum) 		PF06559
(DCD) 		3 TRP A 243
ALA A 235
VAL A 239
 None
 0.78A 1c4dC-2r9qA:
undetectable
1c4dD-2r9qA:
undetectable		 1c4dC-2r9qA:
5.38
1c4dD-2r9qA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU

(Homo sapiens) 		PF00041
(fn3)
PF00047
(ig)
PF00629
(MAM) 		3 TRP A 110
ALA A 126
VAL A 248
 None
 0.83A 1c4dC-2v5yA:
undetectable
1c4dD-2v5yA:
undetectable		 1c4dC-2v5yA:
3.02
1c4dD-2v5yA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		3 TRP A  56
ALA A  77
VAL A  52
 None
 0.87A 1c4dC-2vvtA:
undetectable
1c4dD-2vvtA:
undetectable		 1c4dC-2vvtA:
4.67
1c4dD-2vvtA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzn VENOM ALLERGEN 3

(Solenopsis
invicta) 		PF00188
(CAP) 		3 TRP A  92
ALA A 116
VAL A 193
 None
 0.66A 1c4dC-2vznA:
undetectable
1c4dD-2vznA:
undetectable		 1c4dC-2vznA:
7.46
1c4dD-2vznA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		3 TRP A 100
ALA A  93
VAL A  99
 None
 0.79A 1c4dC-3akfA:
undetectable
1c4dD-3akfA:
undetectable		 1c4dC-3akfA:
2.42
1c4dD-3akfA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auv SC-DSFV DERIVED FROM
THE G6-FAB

(Homo sapiens) 		PF07686
(V-set) 		3 TRP A 167
ALA A 240
VAL A 234
 None
 0.79A 1c4dC-3auvA:
undetectable
1c4dD-3auvA:
undetectable		 1c4dC-3auvA:
7.69
1c4dD-3auvA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9n ALKANE MONOOXYGENASE

(Geobacillus
thermodenitrificans) 		PF00296
(Bac_luciferase) 		3 TRP A 132
ALA A  57
VAL A 103
 None
 0.82A 1c4dC-3b9nA:
undetectable
1c4dD-3b9nA:
undetectable		 1c4dC-3b9nA:
7.55
1c4dD-3b9nA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 TRP A 322
ALA A 297
VAL A 328
 None
 0.93A 1c4dC-3cghA:
undetectable
1c4dD-3cghA:
undetectable		 1c4dC-3cghA:
5.00
1c4dD-3cghA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk6 INTEGRON CASSETTE
PROTEIN VCH_CASS2

(Vibrio cholerae) 		PF14526
(Cass2) 		3 TRP A 111
ALA A  99
VAL A 107
 None
None
PE4  A6061 (-4.6A)
 0.81A 1c4dC-3gk6A:
undetectable
1c4dD-3gk6A:
undetectable		 1c4dC-3gk6A:
9.43
1c4dD-3gk6A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwq D-SERINE DEAMINASE

(Paraburkholderia
xenovorans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 TRP A 315
ALA A 311
VAL A  49
 None
 0.79A 1c4dC-3gwqA:
undetectable
1c4dD-3gwqA:
undetectable		 1c4dC-3gwqA:
3.82
1c4dD-3gwqA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 TRP A 168
ALA A 307
VAL A 253
 None
 0.78A 1c4dC-3h7lA:
undetectable
1c4dD-3h7lA:
undetectable		 1c4dC-3h7lA:
3.31
1c4dD-3h7lA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 TRP A 457
ALA A 405
VAL A 430
 None
 0.87A 1c4dC-3i2tA:
undetectable
1c4dD-3i2tA:
undetectable		 1c4dC-3i2tA:
3.28
1c4dD-3i2tA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 TRP A 605
ALA A 115
VAL A 119
 None
 0.89A 1c4dC-3ilvA:
undetectable
1c4dD-3ilvA:
undetectable		 1c4dC-3ilvA:
3.45
1c4dD-3ilvA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		3 TRP P 393
ALA P 440
VAL P 388
 None
 0.68A 1c4dC-3izyP:
undetectable
1c4dD-3izyP:
undetectable		 1c4dC-3izyP:
2.66
1c4dD-3izyP:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh1 PREDICTED
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Magnetospirillum
magnetotacticum) 		PF13023
(HD_3) 		3 TRP A 156
ALA A 164
VAL A 161
 None
 0.80A 1c4dC-3kh1A:
undetectable
1c4dD-3kh1A:
undetectable		 1c4dC-3kh1A:
5.00
1c4dD-3kh1A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		3 TRP A 311
ALA A  42
VAL A  45
 None
 0.88A 1c4dC-3l12A:
undetectable
1c4dD-3l12A:
undetectable		 1c4dC-3l12A:
5.05
1c4dD-3l12A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm4 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus
jostii) 		PF00903
(Glyoxalase) 		3 TRP A 287
ALA A 191
VAL A 182
 None
 0.88A 1c4dC-3lm4A:
undetectable
1c4dD-3lm4A:
undetectable		 1c4dC-3lm4A:
5.17
1c4dD-3lm4A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o12 UNCHARACTERIZED
PROTEIN YJL217W

(Saccharomyces
cerevisiae) 		PF07081
(DUF1349) 		3 TRP A 115
ALA A  93
VAL A 107
 EDO  A 206 (-3.7A)
None
EDO  A 205 ( 4.9A)
 0.88A 1c4dC-3o12A:
undetectable
1c4dD-3o12A:
undetectable		 1c4dC-3o12A:
5.85
1c4dD-3o12A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc5 PLATELET BINDING
PROTEIN GSPB

(Streptococcus
gordonii) 		no annotation 3 TRP X 386
ALA X 295
VAL X 360
 None
 0.83A 1c4dC-3qc5X:
undetectable
1c4dD-3qc5X:
undetectable		 1c4dC-3qc5X:
5.71
1c4dD-3qc5X:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rht (GATASE1)-LIKE
PROTEIN

(Planctopirus
limnophila) 		PF07090
(GATase1_like) 		3 TRP A 141
ALA A 127
VAL A 131
 None
 0.94A 1c4dC-3rhtA:
undetectable
1c4dD-3rhtA:
undetectable		 1c4dC-3rhtA:
6.52
1c4dD-3rhtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 TRP A 644
ALA A 579
VAL A 608
 None
 0.87A 1c4dC-3s29A:
undetectable
1c4dD-3s29A:
undetectable		 1c4dC-3s29A:
3.51
1c4dD-3s29A:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3see HYPOTHETICAL SUGAR
BINDING PROTEIN

(Bacteroides
thetaiotaomicron) 		PF15425
(DUF4627) 		3 TRP A  47
ALA A  61
VAL A  32
 None
 0.91A 1c4dC-3seeA:
undetectable
1c4dD-3seeA:
undetectable		 1c4dC-3seeA:
5.05
1c4dD-3seeA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 TRP A 276
ALA A 268
VAL A 273
 None
 0.93A 1c4dC-3uj2A:
undetectable
1c4dD-3uj2A:
undetectable		 1c4dC-3uj2A:
3.87
1c4dD-3uj2A:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		3 TRP A 359
ALA A 356
VAL A 311
 None
 0.91A 1c4dC-4au2A:
undetectable
1c4dD-4au2A:
undetectable		 1c4dC-4au2A:
4.04
1c4dD-4au2A:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 TRP A1674
ALA A1616
VAL A1670
 None
 0.52A 1c4dC-4c6oA:
undetectable
1c4dD-4c6oA:
undetectable		 1c4dC-4c6oA:
4.36
1c4dD-4c6oA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 TRP A 513
ALA A 468
VAL A 470
 None
 0.90A 1c4dC-4epaA:
undetectable
1c4dD-4epaA:
undetectable		 1c4dC-4epaA:
2.15
1c4dD-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 TRP A 521
ALA A 572
VAL A 556
 None
 0.73A 1c4dC-4epaA:
undetectable
1c4dD-4epaA:
undetectable		 1c4dC-4epaA:
2.15
1c4dD-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7c CD1D ANTIGEN, D
POLYPEPTIDE

(Bos taurus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		3 TRP A 277
ALA A 252
VAL A 256
 None
 0.70A 1c4dC-4f7cA:
undetectable
1c4dD-4f7cA:
undetectable		 1c4dC-4f7cA:
5.43
1c4dD-4f7cA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		3 TRP A 334
ALA A 270
VAL A 323
 None
 0.93A 1c4dC-4ftdA:
undetectable
1c4dD-4ftdA:
undetectable		 1c4dC-4ftdA:
2.43
1c4dD-4ftdA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN

(Bacteroides
ovatus) 		PF01833
(TIG) 		3 TRP A 174
ALA A 195
VAL A 190
 None
CL  A 506 ( 3.8A)
None
 0.73A 1c4dC-4hw6A:
undetectable
1c4dD-4hw6A:
undetectable		 1c4dC-4hw6A:
5.20
1c4dD-4hw6A:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		3 TRP A 108
ALA A 334
VAL A 107
 None
 0.85A 1c4dC-4hxyA:
undetectable
1c4dD-4hxyA:
undetectable		 1c4dC-4hxyA:
12.84
1c4dD-4hxyA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 3 TRP D 284
ALA D 254
VAL D 283
 None
 0.90A 1c4dC-4jf7D:
undetectable
1c4dD-4jf7D:
undetectable		 1c4dC-4jf7D:
7.04
1c4dD-4jf7D:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lim DNA PRIMASE SMALL
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01896
(DNA_primase_S) 		3 TRP A  31
ALA A 381
VAL A 383
 None
 0.90A 1c4dC-4limA:
undetectable
1c4dD-4limA:
undetectable		 1c4dC-4limA:
5.69
1c4dD-4limA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4w CYTOCHROME
B(562),SMOOTHENED
HOMOLOG

(Shigella
flexneri;
Homo sapiens) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		3 TRP A 537
ALA A 540
VAL A 536
 None
 0.91A 1c4dC-4n4wA:
undetectable
1c4dD-4n4wA:
undetectable		 1c4dC-4n4wA:
3.36
1c4dD-4n4wA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noa TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILE

(Pseudomonas
aeruginosa) 		PF16732
(ComP_DUS) 		3 TRP A 133
ALA A 120
VAL A 129
 None
 0.85A 1c4dC-4noaA:
undetectable
1c4dD-4noaA:
undetectable		 1c4dC-4noaA:
8.97
1c4dD-4noaA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E

(Butyrivibrio
proteoclasticus) 		PF04616
(Glyco_hydro_43) 		3 TRP A 205
ALA A 218
VAL A 216
 None
 0.86A 1c4dC-4novA:
undetectable
1c4dD-4novA:
undetectable		 1c4dC-4novA:
6.07
1c4dD-4novA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o62 ZINC FINGER CW-TYPE
PWWP DOMAIN PROTEIN
2

(Homo sapiens) 		PF07496
(zf-CW) 		3 TRP A  58
ALA A  50
VAL A  52
 None
 0.91A 1c4dC-4o62A:
undetectable
1c4dD-4o62A:
undetectable		 1c4dC-4o62A:
20.51
1c4dD-4o62A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		3 TRP A 537
ALA A 540
VAL A 536
 None
 0.75A 1c4dC-4o9rA:
undetectable
1c4dD-4o9rA:
undetectable		 1c4dC-4o9rA:
3.31
1c4dD-4o9rA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 TRP A  48
ALA A 290
VAL A 308
 None
 0.89A 1c4dC-4oqsA:
undetectable
1c4dD-4oqsA:
undetectable		 1c4dC-4oqsA:
3.20
1c4dD-4oqsA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3i P DOMAIN OF VP1

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		3 TRP A 333
ALA A 384
VAL A 386
 None
 0.92A 1c4dC-4p3iA:
undetectable
1c4dD-4p3iA:
undetectable		 1c4dC-4p3iA:
3.07
1c4dD-4p3iA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		3 TRP A 313
ALA A 290
VAL A 319
 None
 0.94A 1c4dC-4pucA:
undetectable
1c4dD-4pucA:
undetectable		 1c4dC-4pucA:
3.73
1c4dD-4pucA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		3 TRP A 999
ALA A 993
VAL A1037
 None
 0.90A 1c4dC-4qmhA:
undetectable
1c4dD-4qmhA:
undetectable		 1c4dC-4qmhA:
8.00
1c4dD-4qmhA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r30 LAFORIN

(Homo sapiens) 		PF00782
(DSPc) 		3 TRP A 280
ALA A 275
VAL A 249
 None
BME  A 503 ( 4.5A)
None
 0.75A 1c4dC-4r30A:
undetectable
1c4dD-4r30A:
undetectable		 1c4dC-4r30A:
7.80
1c4dD-4r30A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkk LAFORIN

(Homo sapiens) 		PF00686
(CBM_20)
PF00782
(DSPc) 		3 TRP A  60
ALA A  12
VAL A   9
 None
 0.88A 1c4dC-4rkkA:
undetectable
1c4dD-4rkkA:
undetectable		 1c4dC-4rkkA:
4.96
1c4dD-4rkkA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		3 TRP A 165
ALA A 115
VAL A 161
 None
 0.86A 1c4dC-4rnxA:
undetectable
1c4dD-4rnxA:
undetectable		 1c4dC-4rnxA:
3.75
1c4dD-4rnxA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 TRP A3713
ALA A3722
VAL A3719
 None
 0.83A 1c4dC-4tktA:
undetectable
1c4dD-4tktA:
undetectable		 1c4dC-4tktA:
1.99
1c4dD-4tktA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4web HEPATITIS C VIRUS
ENVELOPE
GLYCOPROTEIN 2

(Hepacivirus C) 		PF01560
(HCV_NS1) 		3 TRP E 556
ALA E 501
VAL E 504
 None
 0.77A 1c4dC-4webE:
undetectable
1c4dD-4webE:
undetectable		 1c4dC-4webE:
6.05
1c4dD-4webE:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF00722
(Glyco_hydro_16) 		3 TRP A 149
ALA A 180
VAL A 177
 EDO  A 308 (-3.6A)
None
None
 0.73A 1c4dC-4xdqA:
undetectable
1c4dD-4xdqA:
undetectable		 1c4dC-4xdqA:
5.67
1c4dD-4xdqA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xoq COENZYME
F420:L-GLUTAMATE
LIGASE

(Mycobacterium
tuberculosis) 		PF00881
(Nitroreductase) 		3 TRP A 299
ALA A 425
VAL A 348
 None
 0.72A 1c4dC-4xoqA:
undetectable
1c4dD-4xoqA:
undetectable		 1c4dC-4xoqA:
13.89
1c4dD-4xoqA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		3 TRP A 468
ALA A 500
VAL A 498
 None
 0.91A 1c4dC-4xprA:
undetectable
1c4dD-4xprA:
undetectable		 1c4dC-4xprA:
3.37
1c4dD-4xprA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)

(Mycobacterium
avium) 		PF00722
(Glyco_hydro_16) 		3 TRP A 165
ALA A 196
VAL A 193
 None
 0.75A 1c4dC-4xxpA:
undetectable
1c4dD-4xxpA:
undetectable		 1c4dC-4xxpA:
7.64
1c4dD-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7l TYPE VI SECRETION
PROTEIN ICMF

(Escherichia
coli) 		PF06744
(IcmF_C) 		3 TRP A 887
ALA A 882
VAL A 884
 None
 0.89A 1c4dC-4y7lA:
undetectable
1c4dD-4y7lA:
undetectable		 1c4dC-4y7lA:
4.89
1c4dD-4y7lA:
4.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7m TYPE VI SECRETION
PROTEIN ICMF

(Escherichia
coli) 		PF06744
(IcmF_C) 		3 TRP C 887
ALA C 882
VAL C 884
 None
SO4  C1201 ( 4.0A)
None
 0.90A 1c4dC-4y7mC:
undetectable
1c4dD-4y7mC:
undetectable		 1c4dC-4y7mC:
4.21
1c4dD-4y7mC:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		3 TRP A 316
ALA A 266
VAL A 312
 None
 0.91A 1c4dC-4yncA:
undetectable
1c4dD-4yncA:
undetectable		 1c4dC-4yncA:
3.29
1c4dD-4yncA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjd AGGREGATION
SUPPRESSING PROTEIN

(Salmonella
enterica) 		PF00011
(HSP20) 		3 TRP A  63
ALA A  43
VAL A  60
 None
 0.70A 1c4dC-4zjdA:
undetectable
1c4dD-4zjdA:
undetectable		 1c4dC-4zjdA:
7.27
1c4dD-4zjdA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 TRP 1  89
ALA 1  50
VAL 1 173
 None
 0.91A 1c4dC-5aca1:
undetectable
1c4dD-5aca1:
undetectable		 1c4dC-5aca1:
10.61
1c4dD-5aca1:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		3 TRP A 167
ALA A 315
VAL A 252
 None
 0.83A 1c4dC-5dgqA:
undetectable
1c4dD-5dgqA:
undetectable		 1c4dC-5dgqA:
2.17
1c4dD-5dgqA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		3 TRP A 122
ALA A  56
VAL A  93
 None
PE4  A 501 (-3.0A)
None
 0.88A 1c4dC-5dqpA:
undetectable
1c4dD-5dqpA:
undetectable		 1c4dC-5dqpA:
3.01
1c4dD-5dqpA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		3 TRP A 107
ALA A 318
VAL A  43
 None
 0.84A 1c4dC-5ebbA:
undetectable
1c4dD-5ebbA:
undetectable		 1c4dC-5ebbA:
3.98
1c4dD-5ebbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elg GLUTATHIONE
S-TRANSFERASE DHAR1,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 TRP A 207
ALA A  10
VAL A 203
 GOL  A 301 (-3.3A)
None
None
 0.73A 1c4dC-5elgA:
undetectable
1c4dD-5elgA:
undetectable		 1c4dC-5elgA:
10.81
1c4dD-5elgA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF03358
(FMN_red) 		3 TRP A 127
ALA A 161
VAL A 109
 None
 0.86A 1c4dC-5f12A:
undetectable
1c4dD-5f12A:
undetectable		 1c4dC-5f12A:
6.15
1c4dD-5f12A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		3 TRP A 104
ALA A 315
VAL A  40
 None
 0.88A 1c4dC-5fcaA:
undetectable
1c4dD-5fcaA:
undetectable		 1c4dC-5fcaA:
5.50
1c4dD-5fcaA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		3 TRP A2239
ALA A2233
VAL A2235
 None
 0.93A 1c4dC-5fzoA:
undetectable
1c4dD-5fzoA:
undetectable		 1c4dC-5fzoA:
4.22
1c4dD-5fzoA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		3 TRP A 282
ALA A  10
VAL A  12
 None
 0.94A 1c4dC-5hosA:
undetectable
1c4dD-5hosA:
undetectable		 1c4dC-5hosA:
4.48
1c4dD-5hosA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		3 TRP A 205
ALA A 200
VAL A 360
 None
 0.72A 1c4dC-5ir6A:
undetectable
1c4dD-5ir6A:
undetectable		 1c4dC-5ir6A:
4.04
1c4dD-5ir6A:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		3 TRP A 363
ALA A  15
VAL A 463
 None
 0.93A 1c4dC-5jwzA:
undetectable
1c4dD-5jwzA:
undetectable		 1c4dC-5jwzA:
2.12
1c4dD-5jwzA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbi DESIGN OF ANTIBODIES

(Escherichia
coli) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP L  39
ALA L  54
VAL L  52
 None
 0.90A 1c4dC-5nbiL:
undetectable
1c4dD-5nbiL:
undetectable		 1c4dC-5nbiL:
13.51
1c4dD-5nbiL:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0t PUTATIVE FERRIC
REDUCTASE

(Cylindrospermum
stagnale) 		PF01794
(Ferric_reduct) 		3 TRP A 378
ALA A 371
VAL A 347
 HEM  A 504 ( 3.3A)
None
None
 0.92A 1c4dC-5o0tA:
undetectable
1c4dD-5o0tA:
undetectable		 1c4dC-5o0tA:
12.04
1c4dD-5o0tA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ode GLL2934 PROTEIN

(Gloeobacter
violaceus) 		no annotation 3 TRP A  85
ALA A  21
VAL A  43
 None
 0.75A 1c4dC-5odeA:
undetectable
1c4dD-5odeA:
undetectable		 1c4dC-5odeA:
8.43
1c4dD-5odeA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owg PCYX_EBK42635

(marine
metagenome) 		no annotation 3 TRP A  39
ALA A  68
VAL A  57
 None
 0.86A 1c4dC-5owgA:
undetectable
1c4dD-5owgA:
undetectable		 1c4dC-5owgA:
12.00
1c4dD-5owgA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		3 TRP A 268
ALA A 316
VAL A 266
 None
 0.93A 1c4dC-5tqrA:
undetectable
1c4dD-5tqrA:
undetectable		 1c4dC-5tqrA:
2.38
1c4dD-5tqrA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		3 TRP A  15
ALA A 241
VAL A  12
 None
 0.78A 1c4dC-5uq6A:
undetectable
1c4dD-5uq6A:
undetectable		 1c4dC-5uq6A:
6.03
1c4dD-5uq6A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled) 		3 TRP A 537
ALA A 540
VAL A 536
 None
 0.93A 1c4dC-5v57A:
undetectable
1c4dD-5v57A:
undetectable		 1c4dC-5v57A:
3.00
1c4dD-5v57A:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C

(Mycobacterium
tuberculosis) 		PF01596
(Methyltransf_3) 		3 TRP A  75
ALA A 102
VAL A  71
 None
None
SAM  A 301 (-3.6A)
 0.88A 1c4dC-5x7fA:
undetectable
1c4dD-5x7fA:
undetectable		 1c4dC-5x7fA:
25.58
1c4dD-5x7fA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica) 		no annotation 3 TRP A 105
ALA A 126
VAL A 128
 None
 0.93A 1c4dC-5yhpA:
undetectable
1c4dD-5yhpA:
undetectable		 1c4dC-5yhpA:
5.95
1c4dD-5yhpA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b23 MAJOR HEAD PROTEIN

(Staphylococcus
virus 80alpha) 		no annotation 3 TRP A  98
ALA A 293
VAL A  99
 None
 0.90A 1c4dC-6b23A:
undetectable
1c4dD-6b23A:
undetectable		 1c4dC-6b23A:
6.79
1c4dD-6b23A:
6.79