SIMILAR PATTERNS OF AMINO ACIDS FOR 1C4D_C_DVAC6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnl COLLAGEN XVIII

(Homo sapiens) 		PF06482
(Endostatin) 		3 ALA A  17
VAL A 171
TRP A 120
 None
 0.96A 1c4dC-1bnlA:
undetectable
1c4dD-1bnlA:
undetectable		 1c4dC-1bnlA:
11.21
1c4dD-1bnlA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee6 PECTATE LYASE

(Bacillus sp.
KSM-P15) 		PF03211
(Pectate_lyase) 		3 ALA A  59
VAL A  81
TRP A  78
 None
CA  A 300 (-4.9A)
None
 0.92A 1c4dC-1ee6A:
undetectable
1c4dD-1ee6A:
undetectable		 1c4dC-1ee6A:
7.75
1c4dD-1ee6A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehw NUCLEOSIDE
DIPHOSPHATE KINASE

(Homo sapiens) 		PF00334
(NDK) 		3 ALA A  75
VAL A   9
TRP A  78
 None
 0.90A 1c4dC-1ehwA:
undetectable
1c4dD-1ehwA:
undetectable		 1c4dC-1ehwA:
10.66
1c4dD-1ehwA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ALA A 250
VAL A 139
TRP A 129
 None
 0.91A 1c4dC-1guzA:
undetectable
1c4dD-1guzA:
undetectable		 1c4dC-1guzA:
4.00
1c4dD-1guzA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ALA A  58
VAL A  40
TRP A  61
 None
 0.88A 1c4dC-1h0hA:
undetectable
1c4dD-1h0hA:
undetectable		 1c4dC-1h0hA:
1.57
1c4dD-1h0hA:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ALA A 129
VAL A 166
TRP A 165
 None
 0.91A 1c4dC-1hwwA:
undetectable
1c4dD-1hwwA:
undetectable		 1c4dC-1hwwA:
1.43
1c4dD-1hwwA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ALA A  75
VAL A  68
TRP A  80
 None
 0.80A 1c4dC-1jedA:
undetectable
1c4dD-1jedA:
undetectable		 1c4dC-1jedA:
4.23
1c4dD-1jedA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ALA A 854
VAL A 880
TRP A 858
 None
 0.77A 1c4dC-1kcwA:
undetectable
1c4dD-1kcwA:
undetectable		 1c4dC-1kcwA:
2.18
1c4dD-1kcwA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 ALA A 112
VAL A  15
TRP A  14
 None
 0.92A 1c4dC-1lrwA:
undetectable
1c4dD-1lrwA:
undetectable		 1c4dC-1lrwA:
3.12
1c4dD-1lrwA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n31 L-CYSTEINE/CYSTINE
LYASE C-DES

(Synechocystis
sp. PCC 6714) 		PF00266
(Aminotran_5) 		3 ALA A 332
VAL A 335
TRP A 313
 None
 0.75A 1c4dC-1n31A:
undetectable
1c4dD-1n31A:
undetectable		 1c4dC-1n31A:
4.98
1c4dD-1n31A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 ALA A  75
VAL A 109
TRP A  79
 None
 0.85A 1c4dC-1nxuA:
undetectable
1c4dD-1nxuA:
undetectable		 1c4dC-1nxuA:
2.72
1c4dD-1nxuA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Thermotoga
maritima) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 ALA A 212
VAL A 207
TRP A 183
 None
 0.94A 1c4dC-1o5zA:
undetectable
1c4dD-1o5zA:
undetectable		 1c4dC-1o5zA:
2.77
1c4dD-1o5zA:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 ALA A 241
VAL A  12
TRP A  15
 None
 0.93A 1c4dC-1qfcA:
undetectable
1c4dD-1qfcA:
undetectable		 1c4dC-1qfcA:
5.00
1c4dD-1qfcA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnx VES V 5

(Vespula
vulgaris) 		PF00188
(CAP) 		3 ALA A 114
VAL A 186
TRP A  90
 None
 0.95A 1c4dC-1qnxA:
undetectable
1c4dD-1qnxA:
undetectable		 1c4dC-1qnxA:
4.31
1c4dD-1qnxA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 ALA A 132
VAL A 549
TRP A 217
 FAD  A 605 (-3.3A)
None
None
 0.87A 1c4dC-1qo8A:
undetectable
1c4dD-1qo8A:
undetectable		 1c4dC-1qo8A:
2.95
1c4dD-1qo8A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ALA A  75
VAL A  68
TRP A  80
 None
 0.83A 1c4dC-1r6xA:
undetectable
1c4dD-1r6xA:
undetectable		 1c4dC-1r6xA:
9.09
1c4dD-1r6xA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ALA A 149
VAL A 286
TRP A  87
 None
ETF  A 501 ( 4.8A)
ETF  A 501 (-3.7A)
 0.95A 1c4dC-1rjwA:
undetectable
1c4dD-1rjwA:
undetectable		 1c4dC-1rjwA:
4.00
1c4dD-1rjwA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv6 2-KETO-4-PENTENOATE
HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 ALA A 129
VAL A 111
TRP A 132
 None
 0.86A 1c4dC-1sv6A:
undetectable
1c4dD-1sv6A:
undetectable		 1c4dC-1sv6A:
7.01
1c4dD-1sv6A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 ALA D 244
VAL D 256
TRP D 207
 None
 0.91A 1c4dC-1u0nD:
undetectable
1c4dD-1u0nD:
undetectable		 1c4dC-1u0nD:
4.42
1c4dD-1u0nD:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		3 ALA A 229
VAL A 219
TRP A 217
 None
 0.95A 1c4dC-1v84A:
undetectable
1c4dD-1v84A:
undetectable		 1c4dC-1v84A:
12.22
1c4dD-1v84A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		3 ALA A 249
VAL A 288
TRP A 274
 None
 0.96A 1c4dC-2a8iA:
undetectable
1c4dD-2a8iA:
undetectable		 1c4dC-2a8iA:
5.37
1c4dD-2a8iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj2 HYPOTHETICAL UPF0301
PROTEIN VC0467

(Vibrio cholerae) 		PF02622
(DUF179) 		3 ALA A  54
VAL A  36
TRP A 179
 None
 0.82A 1c4dC-2aj2A:
undetectable
1c4dD-2aj2A:
undetectable		 1c4dC-2aj2A:
8.19
1c4dD-2aj2A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az3 NUCLEOSIDE
DIPHOSPHATE KINASE

(Halobacterium
salinarum) 		PF00334
(NDK) 		3 ALA A  76
VAL A  10
TRP A  79
 None
 0.94A 1c4dC-2az3A:
undetectable
1c4dD-2az3A:
undetectable		 1c4dC-2az3A:
8.80
1c4dD-2az3A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bht CYSTEINE SYNTHASE B

(Escherichia
coli) 		PF00291
(PALP) 		3 ALA A 267
VAL A 274
TRP A  28
 None
 0.96A 1c4dC-2bhtA:
undetectable
1c4dD-2bhtA:
undetectable		 1c4dC-2bhtA:
3.10
1c4dD-2bhtA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		3 ALA X 239
VAL X  10
TRP X  13
 None
 0.90A 1c4dC-2bq8X:
undetectable
1c4dD-2bq8X:
undetectable		 1c4dC-2bq8X:
6.11
1c4dD-2bq8X:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv7 GLYCOLIPID TRANSFER
PROTEIN

(Bos taurus) 		PF08718
(GLTP) 		3 ALA A  93
VAL A  88
TRP A  85
 None
 0.92A 1c4dC-2bv7A:
undetectable
1c4dD-2bv7A:
undetectable		 1c4dC-2bv7A:
9.17
1c4dD-2bv7A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		3 ALA A 181
VAL A 187
TRP A  72
 None
 0.84A 1c4dC-2j6lA:
undetectable
1c4dD-2j6lA:
undetectable		 1c4dC-2j6lA:
3.50
1c4dD-2j6lA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		3 ALA A 179
VAL A 185
TRP A  70
 None
 0.88A 1c4dC-2jg7A:
undetectable
1c4dD-2jg7A:
undetectable		 1c4dC-2jg7A:
2.68
1c4dD-2jg7A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jv8 UNCHARACTERIZED
PROTEIN NE1242

(Nitrosomonas
europaea) 		no annotation 3 ALA A  34
VAL A  31
TRP A  39
 None
 0.90A 1c4dC-2jv8A:
undetectable
1c4dD-2jv8A:
undetectable		 1c4dC-2jv8A:
13.43
1c4dD-2jv8A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqv PROTEIN YEBF

(Escherichia
coli) 		PF13995
(YebF) 		3 ALA A 110
VAL A 106
TRP A  87
 None
 0.96A 1c4dC-2lqvA:
undetectable
1c4dD-2lqvA:
undetectable		 1c4dC-2lqvA:
12.50
1c4dD-2lqvA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyo UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Deinococcus
geothermalis) 		PF02627
(CMD) 		3 ALA A 115
VAL A  83
TRP A 118
 None
 0.94A 1c4dC-2oyoA:
undetectable
1c4dD-2oyoA:
undetectable		 1c4dC-2oyoA:
9.71
1c4dD-2oyoA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE

(Agrobacterium
fabrum) 		PF06559
(DCD) 		3 ALA A 235
VAL A 239
TRP A 243
 None
 0.79A 1c4dC-2r9qA:
undetectable
1c4dD-2r9qA:
undetectable		 1c4dC-2r9qA:
5.38
1c4dD-2r9qA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		3 ALA A 347
VAL A 508
TRP A 460
 None
 0.93A 1c4dC-2vobA:
undetectable
1c4dD-2vobA:
undetectable		 1c4dC-2vobA:
3.50
1c4dD-2vobA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		3 ALA A  77
VAL A  52
TRP A  56
 None
 0.94A 1c4dC-2vvtA:
undetectable
1c4dD-2vvtA:
undetectable		 1c4dC-2vvtA:
4.67
1c4dD-2vvtA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzn VENOM ALLERGEN 3

(Solenopsis
invicta) 		PF00188
(CAP) 		3 ALA A 116
VAL A 193
TRP A  92
 None
 0.78A 1c4dC-2vznA:
undetectable
1c4dD-2vznA:
undetectable		 1c4dC-2vznA:
7.46
1c4dD-2vznA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0i MALATE DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ALA A 298
VAL A 160
TRP A 150
 None
 0.87A 1c4dC-2x0iA:
undetectable
1c4dD-2x0iA:
undetectable		 1c4dC-2x0iA:
4.15
1c4dD-2x0iA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zua NUCLEOSIDE
DIPHOSPHATE KINASE

(Haloarcula
quadrata) 		PF00334
(NDK) 		3 ALA A  75
VAL A   9
TRP A  78
 None
 0.93A 1c4dC-2zuaA:
undetectable
1c4dD-2zuaA:
undetectable		 1c4dC-2zuaA:
10.08
1c4dD-2zuaA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		3 ALA A  93
VAL A  99
TRP A 100
 None
 0.70A 1c4dC-3akfA:
undetectable
1c4dD-3akfA:
undetectable		 1c4dC-3akfA:
2.42
1c4dD-3akfA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auv SC-DSFV DERIVED FROM
THE G6-FAB

(Homo sapiens) 		PF07686
(V-set) 		3 ALA A 240
VAL A 234
TRP A 167
 None
 0.75A 1c4dC-3auvA:
undetectable
1c4dD-3auvA:
undetectable		 1c4dC-3auvA:
7.69
1c4dD-3auvA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9n ALKANE MONOOXYGENASE

(Geobacillus
thermodenitrificans) 		PF00296
(Bac_luciferase) 		3 ALA A  57
VAL A 103
TRP A 132
 None
 0.71A 1c4dC-3b9nA:
undetectable
1c4dD-3b9nA:
undetectable		 1c4dC-3b9nA:
7.55
1c4dD-3b9nA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgg SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		3 ALA A 148
VAL A 153
TRP A 152
 None
NHE  A 196 ( 4.6A)
None
 0.88A 1c4dC-3cggA:
undetectable
1c4dD-3cggA:
undetectable		 1c4dC-3cggA:
12.50
1c4dD-3cggA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk6 INTEGRON CASSETTE
PROTEIN VCH_CASS2

(Vibrio cholerae) 		PF14526
(Cass2) 		3 ALA A  99
VAL A 107
TRP A 111
 None
PE4  A6061 (-4.6A)
None
 0.86A 1c4dC-3gk6A:
undetectable
1c4dD-3gk6A:
undetectable		 1c4dC-3gk6A:
9.43
1c4dD-3gk6A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwq D-SERINE DEAMINASE

(Paraburkholderia
xenovorans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 ALA A 311
VAL A  49
TRP A 315
 None
 0.87A 1c4dC-3gwqA:
undetectable
1c4dD-3gwqA:
undetectable		 1c4dC-3gwqA:
3.82
1c4dD-3gwqA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 ALA A 307
VAL A 253
TRP A 168
 None
 0.80A 1c4dC-3h7lA:
undetectable
1c4dD-3h7lA:
undetectable		 1c4dC-3h7lA:
3.31
1c4dD-3h7lA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 ALA A 405
VAL A 430
TRP A 457
 None
 0.93A 1c4dC-3i2tA:
undetectable
1c4dD-3i2tA:
undetectable		 1c4dC-3i2tA:
3.28
1c4dD-3i2tA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		3 ALA P 440
VAL P 388
TRP P 393
 None
 0.67A 1c4dC-3izyP:
undetectable
1c4dD-3izyP:
undetectable		 1c4dC-3izyP:
2.66
1c4dD-3izyP:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh1 PREDICTED
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Magnetospirillum
magnetotacticum) 		PF13023
(HD_3) 		3 ALA A 164
VAL A 161
TRP A 156
 None
 0.87A 1c4dC-3kh1A:
undetectable
1c4dD-3kh1A:
undetectable		 1c4dC-3kh1A:
5.00
1c4dD-3kh1A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lll PROTEIN KINASE C AND
CASEIN KINASE
SUBSTRATE IN NEURONS
PROTEIN 2

(Mus musculus) 		PF00611
(FCH) 		3 ALA A  64
VAL A  87
TRP A  84
 None
 0.80A 1c4dC-3lllA:
undetectable
1c4dD-3lllA:
undetectable		 1c4dC-3lllA:
4.30
1c4dD-3lllA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nep MALATE DEHYDROGENASE

(Salinibacter
ruber) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ALA X  29
VAL X  32
TRP X 247
 None
 0.92A 1c4dC-3nepX:
undetectable
1c4dD-3nepX:
undetectable		 1c4dC-3nepX:
5.58
1c4dD-3nepX:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 3 ALA A  94
VAL A 313
TRP A 317
 None
 0.81A 1c4dC-3phfA:
undetectable
1c4dD-3phfA:
undetectable		 1c4dC-3phfA:
2.37
1c4dD-3phfA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		3 ALA A  37
VAL A  35
TRP A 114
 None
 0.92A 1c4dC-3qokA:
undetectable
1c4dD-3qokA:
undetectable		 1c4dC-3qokA:
3.23
1c4dD-3qokA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 ALA A 579
VAL A 608
TRP A 644
 None
 0.92A 1c4dC-3s29A:
undetectable
1c4dD-3s29A:
undetectable		 1c4dC-3s29A:
3.51
1c4dD-3s29A:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ALA A 268
VAL A 273
TRP A 276
 None
 0.94A 1c4dC-3uj2A:
undetectable
1c4dD-3uj2A:
undetectable		 1c4dC-3uj2A:
3.87
1c4dD-3uj2A:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		3 ALA A  50
VAL A  47
TRP A  44
 None
 0.87A 1c4dC-3vocA:
undetectable
1c4dD-3vocA:
undetectable		 1c4dC-3vocA:
9.52
1c4dD-3vocA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 ALA A1616
VAL A1670
TRP A1674
 None
 0.70A 1c4dC-4c6oA:
undetectable
1c4dD-4c6oA:
undetectable		 1c4dC-4c6oA:
4.36
1c4dD-4c6oA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ALA A 572
VAL A 556
TRP A 521
 None
 0.88A 1c4dC-4epaA:
undetectable
1c4dD-4epaA:
undetectable		 1c4dC-4epaA:
2.15
1c4dD-4epaA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew9 PECTATE LYASE

(Caldicellulosiruptor
bescii) 		PF03211
(Pectate_lyase) 		3 ALA A  60
VAL A  82
TRP A  79
 None
CA  A 201 (-4.9A)
None
 0.86A 1c4dC-4ew9A:
undetectable
1c4dD-4ew9A:
undetectable		 1c4dC-4ew9A:
11.76
1c4dD-4ew9A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		3 ALA A 362
VAL A 323
TRP A 334
 None
 0.86A 1c4dC-4ftdA:
undetectable
1c4dD-4ftdA:
undetectable		 1c4dC-4ftdA:
2.43
1c4dD-4ftdA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		3 ALA A 247
VAL A 259
TRP A 292
 None
 0.88A 1c4dC-4gyoA:
undetectable
1c4dD-4gyoA:
undetectable		 1c4dC-4gyoA:
3.64
1c4dD-4gyoA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN

(Bacteroides
ovatus) 		PF01833
(TIG) 		3 ALA A 195
VAL A 190
TRP A 174
 CL  A 506 ( 3.8A)
None
None
 0.70A 1c4dC-4hw6A:
undetectable
1c4dD-4hw6A:
undetectable		 1c4dC-4hw6A:
5.20
1c4dD-4hw6A:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2

(Homo sapiens) 		PF00061
(Lipocalin) 		3 ALA A  35
VAL A  33
TRP A  32
 None
None
RET  A 201 (-4.5A)
 0.93A 1c4dC-4i9rA:
undetectable
1c4dD-4i9rA:
undetectable		 1c4dC-4i9rA:
10.48
1c4dD-4i9rA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 3 ALA A 262
VAL A 141
TRP A 139
 None
 0.95A 1c4dC-4iegA:
undetectable
1c4dD-4iegA:
undetectable		 1c4dC-4iegA:
2.48
1c4dD-4iegA:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ALA A  61
VAL A  57
TRP A  74
 None
None
GOL  A 501 (-3.4A)
 0.93A 1c4dC-4j6fA:
undetectable
1c4dD-4j6fA:
undetectable		 1c4dC-4j6fA:
5.29
1c4dD-4j6fA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 3 ALA D 254
VAL D 283
TRP D 284
 None
 0.76A 1c4dC-4jf7D:
undetectable
1c4dD-4jf7D:
undetectable		 1c4dC-4jf7D:
7.04
1c4dD-4jf7D:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsq HEAVY CHAIN OF
ANTIBODY VRC-CH31
LIGHT CHAIN OF
ANTIBODY VRC-CH31
WITH N70D MUTATION

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 ALA H 100
VAL L  48
TRP L  35
 None
 0.90A 1c4dC-4lsqH:
undetectable
1c4dD-4lsqH:
undetectable		 1c4dC-4lsqH:
5.62
1c4dD-4lsqH:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		3 ALA A 595
VAL A 453
TRP A 451
 None
 0.77A 1c4dC-4mifA:
undetectable
1c4dD-4mifA:
undetectable		 1c4dC-4mifA:
2.22
1c4dD-4mifA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		3 ALA A 221
VAL A 234
TRP A 226
 None
 0.88A 1c4dC-4n4pA:
undetectable
1c4dD-4n4pA:
undetectable		 1c4dC-4n4pA:
4.56
1c4dD-4n4pA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E

(Butyrivibrio
proteoclasticus) 		PF04616
(Glyco_hydro_43) 		3 ALA A 218
VAL A 216
TRP A 205
 None
 0.89A 1c4dC-4novA:
undetectable
1c4dD-4novA:
undetectable		 1c4dC-4novA:
6.07
1c4dD-4novA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		3 ALA A 540
VAL A 536
TRP A 537
 None
 0.89A 1c4dC-4o9rA:
undetectable
1c4dD-4o9rA:
undetectable		 1c4dC-4o9rA:
3.31
1c4dD-4o9rA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3i P DOMAIN OF VP1

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		3 ALA A 384
VAL A 386
TRP A 333
 None
 0.92A 1c4dC-4p3iA:
undetectable
1c4dD-4p3iA:
undetectable		 1c4dC-4p3iA:
3.07
1c4dD-4p3iA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r30 LAFORIN

(Homo sapiens) 		PF00782
(DSPc) 		3 ALA A 275
VAL A 249
TRP A 280
 BME  A 503 ( 4.5A)
None
None
 0.90A 1c4dC-4r30A:
undetectable
1c4dD-4r30A:
undetectable		 1c4dC-4r30A:
7.80
1c4dD-4r30A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkk LAFORIN

(Homo sapiens) 		PF00686
(CBM_20)
PF00782
(DSPc) 		3 ALA A  12
VAL A   9
TRP A  60
 None
 0.95A 1c4dC-4rkkA:
undetectable
1c4dD-4rkkA:
undetectable		 1c4dC-4rkkA:
4.96
1c4dD-4rkkA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4web HEPATITIS C VIRUS
ENVELOPE
GLYCOPROTEIN 2

(Hepacivirus C) 		PF01560
(HCV_NS1) 		3 ALA E 501
VAL E 504
TRP E 556
 None
 0.90A 1c4dC-4webE:
undetectable
1c4dD-4webE:
undetectable		 1c4dC-4webE:
6.05
1c4dD-4webE:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xoq COENZYME
F420:L-GLUTAMATE
LIGASE

(Mycobacterium
tuberculosis) 		PF00881
(Nitroreductase) 		3 ALA A 425
VAL A 348
TRP A 299
 None
 0.85A 1c4dC-4xoqA:
undetectable
1c4dD-4xoqA:
undetectable		 1c4dC-4xoqA:
13.89
1c4dD-4xoqA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		3 ALA A  95
VAL A  88
TRP A  85
 None
 0.76A 1c4dC-4zfmA:
undetectable
1c4dD-4zfmA:
undetectable		 1c4dC-4zfmA:
2.93
1c4dD-4zfmA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjd AGGREGATION
SUPPRESSING PROTEIN

(Salmonella
enterica) 		PF00011
(HSP20) 		3 ALA A  43
VAL A  60
TRP A  63
 None
 0.94A 1c4dC-4zjdA:
undetectable
1c4dD-4zjdA:
undetectable		 1c4dC-4zjdA:
7.27
1c4dD-4zjdA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		3 ALA A1303
VAL A1308
TRP A1252
 None
 0.90A 1c4dC-5a42A:
undetectable
1c4dD-5a42A:
undetectable		 1c4dC-5a42A:
1.05
1c4dD-5a42A:
1.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 ALA 1  50
VAL 1 173
TRP 1  89
 None
 0.90A 1c4dC-5aca1:
undetectable
1c4dD-5aca1:
undetectable		 1c4dC-5aca1:
10.61
1c4dD-5aca1:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 ALA A 387
VAL A 517
TRP A 649
 None
 0.93A 1c4dC-5b3hA:
undetectable
1c4dD-5b3hA:
undetectable		 1c4dC-5b3hA:
9.76
1c4dD-5b3hA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 ALA A 387
VAL A 519
TRP A 649
 None
 0.95A 1c4dC-5b3hA:
undetectable
1c4dD-5b3hA:
undetectable		 1c4dC-5b3hA:
9.76
1c4dD-5b3hA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		3 ALA A 315
VAL A 252
TRP A 167
 None
 0.90A 1c4dC-5dgqA:
undetectable
1c4dD-5dgqA:
undetectable		 1c4dC-5dgqA:
2.17
1c4dD-5dgqA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		3 ALA A  56
VAL A  93
TRP A 122
 PE4  A 501 (-3.0A)
None
None
 0.75A 1c4dC-5dqpA:
undetectable
1c4dD-5dqpA:
undetectable		 1c4dC-5dqpA:
3.01
1c4dD-5dqpA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		3 ALA A 318
VAL A  43
TRP A 107
 None
 0.76A 1c4dC-5ebbA:
undetectable
1c4dD-5ebbA:
undetectable		 1c4dC-5ebbA:
3.98
1c4dD-5ebbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elg GLUTATHIONE
S-TRANSFERASE DHAR1,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 ALA A  10
VAL A 203
TRP A 207
 None
None
GOL  A 301 (-3.3A)
 0.81A 1c4dC-5elgA:
undetectable
1c4dD-5elgA:
undetectable		 1c4dC-5elgA:
10.81
1c4dD-5elgA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF03358
(FMN_red) 		3 ALA A 161
VAL A 109
TRP A 127
 None
 0.89A 1c4dC-5f12A:
undetectable
1c4dD-5f12A:
undetectable		 1c4dC-5f12A:
6.15
1c4dD-5f12A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		3 ALA A 315
VAL A  40
TRP A 104
 None
 0.78A 1c4dC-5fcaA:
undetectable
1c4dD-5fcaA:
undetectable		 1c4dC-5fcaA:
5.50
1c4dD-5fcaA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		3 ALA A  92
VAL A 113
TRP A 117
 None
 0.90A 1c4dC-5feiA:
undetectable
1c4dD-5feiA:
undetectable		 1c4dC-5feiA:
1.91
1c4dD-5feiA:
1.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		3 ALA A  97
VAL A  90
TRP A  87
 None
 0.94A 1c4dC-5gnxA:
undetectable
1c4dD-5gnxA:
undetectable		 1c4dC-5gnxA:
4.25
1c4dD-5gnxA:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 ALA A 446
VAL A 369
TRP A 367
 None
 0.92A 1c4dC-5hm7A:
undetectable
1c4dD-5hm7A:
undetectable		 1c4dC-5hm7A:
3.81
1c4dD-5hm7A:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		3 ALA A  10
VAL A  12
TRP A 282
 None
 0.83A 1c4dC-5hosA:
undetectable
1c4dD-5hosA:
undetectable		 1c4dC-5hosA:
4.48
1c4dD-5hosA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		3 ALA A 249
VAL A  12
TRP A 282
 None
 0.95A 1c4dC-5hosA:
undetectable
1c4dD-5hosA:
undetectable		 1c4dC-5hosA:
4.48
1c4dD-5hosA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		3 ALA A 200
VAL A 360
TRP A 205
 None
 0.78A 1c4dC-5ir6A:
undetectable
1c4dD-5ir6A:
undetectable		 1c4dC-5ir6A:
4.04
1c4dD-5ir6A:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		3 ALA A  15
VAL A 463
TRP A 363
 None
 0.91A 1c4dC-5jwzA:
undetectable
1c4dD-5jwzA:
undetectable		 1c4dC-5jwzA:
2.12
1c4dD-5jwzA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lyk BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 ALA A 476
VAL A 399
TRP A 397
 None
 0.92A 1c4dC-5lykA:
undetectable
1c4dD-5lykA:
undetectable		 1c4dC-5lykA:
8.57
1c4dD-5lykA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj7 UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF01156
(IU_nuc_hydro) 		3 ALA A 175
VAL A 166
TRP A 202
 None
 0.92A 1c4dC-5mj7A:
undetectable
1c4dD-5mj7A:
undetectable		 1c4dC-5mj7A:
3.98
1c4dD-5mj7A:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 3 ALA A  90
VAL A  83
TRP A  80
 None
 0.88A 1c4dC-5ns8A:
undetectable
1c4dD-5ns8A:
undetectable		 1c4dC-5ns8A:
undetectable
1c4dD-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		3 ALA A 241
VAL A  12
TRP A  15
 None
 0.91A 1c4dC-5uq6A:
undetectable
1c4dD-5uq6A:
undetectable		 1c4dC-5uq6A:
6.03
1c4dD-5uq6A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 3 ALA A 143
VAL A  46
TRP A  45
 None
 0.94A 1c4dC-5xm3A:
undetectable
1c4dD-5xm3A:
undetectable		 1c4dC-5xm3A:
undetectable
1c4dD-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		3 ALA A2752
VAL A2747
TRP A2737
 None
 0.89A 1c4dC-5xn7A:
undetectable
1c4dD-5xn7A:
undetectable		 1c4dC-5xn7A:
2.10
1c4dD-5xn7A:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dde MU-TYPE OPIOID
RECEPTOR

(Mus musculus) 		no annotation 3 ALA R 184
VAL R 189
TRP R 192
 None
 0.94A 1c4dC-6ddeR:
undetectable
1c4dD-6ddeR:
undetectable		 1c4dC-6ddeR:
undetectable
1c4dD-6ddeR:
undetectable