SIMILAR PATTERNS OF AMINO ACIDS FOR 1C4D_B_DVAB6_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cdo ALCOHOL
DEHYDROGENASE

(Gadus morhua) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 TRP A  15
ALA A  12
VAL A  22
 None
 0.86A 1c4dA-1cdoA:
undetectable
1c4dB-1cdoA:
undetectable		 1c4dA-1cdoA:
5.26
1c4dB-1cdoA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 TRP A 391
ALA A 436
VAL A 390
 None
 0.88A 1c4dA-1clwA:
undetectable
1c4dB-1clwA:
undetectable		 1c4dA-1clwA:
2.32
1c4dB-1clwA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqd PROTEIN (PROTEASE
II)

(Zingiber
officinale) 		PF00112
(Peptidase_C1) 		3 TRP A   9
ALA A  35
VAL A 166
 None
 0.94A 1c4dA-1cqdA:
undetectable
1c4dB-1cqdA:
undetectable		 1c4dA-1cqdA:
11.49
1c4dB-1cqdA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehw NUCLEOSIDE
DIPHOSPHATE KINASE

(Homo sapiens) 		PF00334
(NDK) 		3 TRP A  78
ALA A  75
VAL A   9
 None
 0.79A 1c4dA-1ehwA:
undetectable
1c4dB-1ehwA:
undetectable		 1c4dA-1ehwA:
10.66
1c4dB-1ehwA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyv N-UTILIZING
SUBSTANCE PROTEIN B
HOMOLOG

(Mycobacterium
tuberculosis) 		PF01029
(NusB) 		3 TRP A  98
ALA A  32
VAL A  62
 None
 0.88A 1c4dA-1eyvA:
undetectable
1c4dB-1eyvA:
undetectable		 1c4dA-1eyvA:
7.09
1c4dB-1eyvA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE

(Lactobacillus
pentosus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TRP A 148
ALA A 274
VAL A 158
 None
 0.87A 1c4dA-1ez4A:
undetectable
1c4dB-1ez4A:
undetectable		 1c4dA-1ez4A:
8.13
1c4dB-1ez4A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 TRP A  61
ALA A  58
VAL A  40
 None
 0.83A 1c4dA-1h0hA:
undetectable
1c4dB-1h0hA:
undetectable		 1c4dA-1h0hA:
1.57
1c4dB-1h0hA:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 TRP A 165
ALA A 129
VAL A 166
 None
 0.90A 1c4dA-1hwwA:
undetectable
1c4dB-1hwwA:
undetectable		 1c4dA-1hwwA:
1.43
1c4dB-1hwwA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TRP A 858
ALA A 854
VAL A 880
 None
 0.86A 1c4dA-1kcwA:
undetectable
1c4dB-1kcwA:
undetectable		 1c4dA-1kcwA:
2.18
1c4dB-1kcwA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TRP A 148
ALA A 274
VAL A 158
 None
 0.80A 1c4dA-1ldnA:
undetectable
1c4dB-1ldnA:
undetectable		 1c4dA-1ldnA:
6.40
1c4dB-1ldnA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n31 L-CYSTEINE/CYSTINE
LYASE C-DES

(Synechocystis
sp. PCC 6714) 		PF00266
(Aminotran_5) 		3 TRP A 313
ALA A 332
VAL A 335
 None
 0.88A 1c4dA-1n31A:
undetectable
1c4dB-1n31A:
undetectable		 1c4dA-1n31A:
4.98
1c4dB-1n31A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 TRP A 519
ALA A 500
VAL A 503
 None
 0.96A 1c4dA-1ogyA:
undetectable
1c4dB-1ogyA:
undetectable		 1c4dA-1ogyA:
5.19
1c4dB-1ogyA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qap QUINOLINIC ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 TRP A  72
ALA A  24
VAL A  26
 None
 0.95A 1c4dA-1qapA:
undetectable
1c4dB-1qapA:
undetectable		 1c4dA-1qapA:
7.69
1c4dB-1qapA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 TRP A 217
ALA A 132
VAL A 549
 None
FAD  A 605 (-3.3A)
None
 0.94A 1c4dA-1qo8A:
undetectable
1c4dB-1qo8A:
undetectable		 1c4dA-1qo8A:
2.95
1c4dB-1qo8A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		3 TRP A 115
ALA A  31
VAL A  90
 None
 0.86A 1c4dA-1tjyA:
undetectable
1c4dB-1tjyA:
undetectable		 1c4dA-1tjyA:
5.63
1c4dB-1tjyA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umi F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF04300
(FBA) 		3 TRP A 150
ALA A 183
VAL A 143
 None
 0.96A 1c4dA-1umiA:
undetectable
1c4dB-1umiA:
undetectable		 1c4dA-1umiA:
5.48
1c4dB-1umiA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uww ENDOGLUCANASE

(Bacillus akibai) 		PF03424
(CBM_17_28) 		3 TRP A 119
ALA A 122
VAL A 120
 None
 0.89A 1c4dA-1uwwA:
undetectable
1c4dB-1uwwA:
undetectable		 1c4dA-1uwwA:
12.00
1c4dB-1uwwA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		3 TRP A 217
ALA A 229
VAL A 219
 None
 0.94A 1c4dA-1v84A:
undetectable
1c4dB-1v84A:
undetectable		 1c4dA-1v84A:
12.22
1c4dB-1v84A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az3 NUCLEOSIDE
DIPHOSPHATE KINASE

(Halobacterium
salinarum) 		PF00334
(NDK) 		3 TRP A  79
ALA A  76
VAL A  10
 None
 0.90A 1c4dA-2az3A:
undetectable
1c4dB-2az3A:
undetectable		 1c4dA-2az3A:
8.80
1c4dB-2az3A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 TRP A 106
ALA A 132
VAL A 268
 None
 0.93A 1c4dA-2c0yA:
undetectable
1c4dB-2c0yA:
undetectable		 1c4dA-2c0yA:
7.01
1c4dB-2c0yA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		3 TRP A 225
ALA A 189
VAL A 191
 None
 0.81A 1c4dA-2ciyA:
undetectable
1c4dB-2ciyA:
undetectable		 1c4dA-2ciyA:
6.22
1c4dB-2ciyA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsl HYPOTHETICAL PROTEIN

(Fusobacterium
nucleatum) 		PF00636
(Ribonuclease_3) 		3 TRP A  26
ALA A  54
VAL A  52
 None
 0.95A 1c4dA-2gslA:
undetectable
1c4dB-2gslA:
undetectable		 1c4dA-2gslA:
8.05
1c4dB-2gslA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu0 NONSTRUCTURAL
PROTEIN 2

(Rotavirus C) 		PF02509
(Rota_NS35) 		3 TRP A 223
ALA A 203
VAL A 262
 None
 0.78A 1c4dA-2gu0A:
undetectable
1c4dB-2gu0A:
undetectable		 1c4dA-2gu0A:
4.12
1c4dB-2gu0A:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TRP A 304
ALA A 413
VAL A 314
 None
 0.88A 1c4dA-2i6tA:
undetectable
1c4dB-2i6tA:
undetectable		 1c4dA-2i6tA:
4.23
1c4dB-2i6tA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lek PUTATIVE THIAMIN
BIOSYNTHESIS THIS

(Rhodopseudomonas
palustris) 		PF02597
(ThiS) 		3 TRP A  45
ALA A  19
VAL A  17
 None
 0.90A 1c4dA-2lekA:
undetectable
1c4dB-2lekA:
undetectable		 1c4dA-2lekA:
17.31
1c4dB-2lekA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 TRP A 793
ALA A 806
VAL A 803
 None
 0.95A 1c4dA-2q1fA:
undetectable
1c4dB-2q1fA:
undetectable		 1c4dA-2q1fA:
2.16
1c4dB-2q1fA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE

(Agrobacterium
fabrum) 		PF06559
(DCD) 		3 TRP A 243
ALA A 235
VAL A 239
 None
 0.94A 1c4dA-2r9qA:
undetectable
1c4dB-2r9qA:
undetectable		 1c4dA-2r9qA:
5.38
1c4dB-2r9qA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
graminearum) 		PF02458
(Transferase) 		3 TRP A 270
ALA A 369
VAL A 375
 None
 0.88A 1c4dA-2rkvA:
undetectable
1c4dB-2rkvA:
undetectable		 1c4dA-2rkvA:
4.59
1c4dB-2rkvA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		3 TRP A  56
ALA A  77
VAL A  52
 None
 0.87A 1c4dA-2vvtA:
undetectable
1c4dB-2vvtA:
undetectable		 1c4dA-2vvtA:
4.67
1c4dB-2vvtA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zua NUCLEOSIDE
DIPHOSPHATE KINASE

(Haloarcula
quadrata) 		PF00334
(NDK) 		3 TRP A  78
ALA A  75
VAL A   9
 None
 0.80A 1c4dA-2zuaA:
undetectable
1c4dB-2zuaA:
undetectable		 1c4dA-2zuaA:
10.08
1c4dB-2zuaA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zym SOLUTE-BINDING
PROTEIN

(Thermoactinomyces
vulgaris) 		PF13416
(SBP_bac_8) 		3 TRP A  24
ALA A  27
VAL A  54
 None
 0.91A 1c4dA-2zymA:
undetectable
1c4dB-2zymA:
undetectable		 1c4dA-2zymA:
13.58
1c4dB-2zymA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4c DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF16679
(CDT1_C) 		3 TRP A 521
ALA A 542
VAL A 539
 None
 0.89A 1c4dA-3a4cA:
undetectable
1c4dB-3a4cA:
undetectable		 1c4dA-3a4cA:
18.18
1c4dB-3a4cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		3 TRP A 100
ALA A  93
VAL A  99
 None
 0.54A 1c4dA-3akfA:
undetectable
1c4dB-3akfA:
undetectable		 1c4dA-3akfA:
2.42
1c4dB-3akfA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auv SC-DSFV DERIVED FROM
THE G6-FAB

(Homo sapiens) 		PF07686
(V-set) 		3 TRP A 167
ALA A 240
VAL A 234
 None
 0.95A 1c4dA-3auvA:
undetectable
1c4dB-3auvA:
undetectable		 1c4dA-3auvA:
7.69
1c4dB-3auvA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0u UNCHARACTERIZED
PROTEIN YAEQ

(Escherichia
coli) 		PF07152
(YaeQ) 		3 TRP A  81
ALA A 100
VAL A 102
 None
 0.79A 1c4dA-3c0uA:
undetectable
1c4dB-3c0uA:
undetectable		 1c4dA-3c0uA:
7.22
1c4dB-3c0uA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgg SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		3 TRP A 152
ALA A 148
VAL A 153
 None
None
NHE  A 196 ( 4.6A)
 0.93A 1c4dA-3cggA:
undetectable
1c4dB-3cggA:
undetectable		 1c4dA-3cggA:
12.50
1c4dB-3cggA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 TRP A 506
ALA A 493
VAL A 499
 None
 0.94A 1c4dA-3egwA:
undetectable
1c4dB-3egwA:
undetectable		 1c4dA-3egwA:
1.73
1c4dB-3egwA:
1.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejw SMLSRB

(Sinorhizobium
meliloti) 		PF13407
(Peripla_BP_4) 		3 TRP A  89
ALA A   5
VAL A  64
 None
 0.87A 1c4dA-3ejwA:
undetectable
1c4dB-3ejwA:
undetectable		 1c4dA-3ejwA:
5.17
1c4dB-3ejwA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk6 INTEGRON CASSETTE
PROTEIN VCH_CASS2

(Vibrio cholerae) 		PF14526
(Cass2) 		3 TRP A 111
ALA A  99
VAL A 107
 None
None
PE4  A6061 (-4.6A)
 0.91A 1c4dA-3gk6A:
undetectable
1c4dB-3gk6A:
undetectable		 1c4dA-3gk6A:
9.43
1c4dB-3gk6A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TRP A 134
ALA A 259
VAL A 144
 None
 0.92A 1c4dA-3h3jA:
undetectable
1c4dB-3h3jA:
undetectable		 1c4dA-3h3jA:
3.42
1c4dB-3h3jA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 TRP A 168
ALA A 307
VAL A 253
 None
 0.80A 1c4dA-3h7lA:
undetectable
1c4dB-3h7lA:
undetectable		 1c4dA-3h7lA:
3.31
1c4dB-3h7lA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		3 TRP A 312
ALA A 338
VAL A 336
 None
 0.95A 1c4dA-3hq2A:
undetectable
1c4dB-3hq2A:
undetectable		 1c4dA-3hq2A:
2.98
1c4dB-3hq2A:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		3 TRP A  68
ALA A 350
VAL A 352
 None
 0.92A 1c4dA-3i1iA:
undetectable
1c4dB-3i1iA:
undetectable		 1c4dA-3i1iA:
2.85
1c4dB-3i1iA:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		3 TRP A 128
ALA A 118
VAL A 122
 None
 0.96A 1c4dA-3ik2A:
undetectable
1c4dB-3ik2A:
undetectable		 1c4dA-3ik2A:
4.27
1c4dB-3ik2A:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioq CMS1MS2

(Vasconcellea
cundinamarcensis) 		PF00112
(Peptidase_C1) 		3 TRP A   7
ALA A  33
VAL A 164
 None
 0.93A 1c4dA-3ioqA:
undetectable
1c4dB-3ioqA:
undetectable		 1c4dA-3ioqA:
15.07
1c4dB-3ioqA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		3 TRP A 113
ALA A  24
VAL A 147
 None
 0.84A 1c4dA-3it4A:
undetectable
1c4dB-3it4A:
undetectable		 1c4dA-3it4A:
9.65
1c4dB-3it4A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		3 TRP A 113
ALA A  25
VAL A 147
 None
 0.90A 1c4dA-3it4A:
undetectable
1c4dB-3it4A:
undetectable		 1c4dA-3it4A:
9.65
1c4dB-3it4A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		3 TRP P 393
ALA P 440
VAL P 388
 None
 0.78A 1c4dA-3izyP:
undetectable
1c4dB-3izyP:
undetectable		 1c4dA-3izyP:
2.66
1c4dB-3izyP:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 TRP A 321
ALA A 296
VAL A 294
 None
 0.95A 1c4dA-3jtmA:
undetectable
1c4dB-3jtmA:
undetectable		 1c4dA-3jtmA:
3.50
1c4dB-3jtmA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		3 TRP A 311
ALA A  42
VAL A  45
 None
 0.95A 1c4dA-3l12A:
undetectable
1c4dB-3l12A:
undetectable		 1c4dA-3l12A:
5.05
1c4dB-3l12A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lll PROTEIN KINASE C AND
CASEIN KINASE
SUBSTRATE IN NEURONS
PROTEIN 2

(Mus musculus) 		PF00611
(FCH) 		3 TRP A  84
ALA A  64
VAL A  87
 None
 0.85A 1c4dA-3lllA:
undetectable
1c4dB-3lllA:
undetectable		 1c4dA-3lllA:
4.30
1c4dB-3lllA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmb UNCHARACTERIZED
PROTEIN

(Oleispira
antarctica) 		PF09500
(YiiD_C) 		3 TRP A  70
ALA A 160
VAL A  88
 None
 0.91A 1c4dA-3lmbA:
undetectable
1c4dB-3lmbA:
undetectable		 1c4dA-3lmbA:
6.45
1c4dB-3lmbA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luq SENSOR PROTEIN

(Geobacter
sulfurreducens) 		PF08448
(PAS_4) 		3 TRP A 182
ALA A 103
VAL A 192
 None
 0.95A 1c4dA-3luqA:
undetectable
1c4dB-3luqA:
undetectable		 1c4dA-3luqA:
9.78
1c4dB-3luqA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		3 TRP A 153
ALA A 391
VAL A 155
 None
 0.92A 1c4dA-3m4xA:
undetectable
1c4dB-3m4xA:
undetectable		 1c4dA-3m4xA:
5.81
1c4dB-3m4xA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nep MALATE DEHYDROGENASE

(Salinibacter
ruber) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TRP X 247
ALA X  29
VAL X  32
 None
 0.93A 1c4dA-3nepX:
undetectable
1c4dB-3nepX:
undetectable		 1c4dA-3nepX:
5.58
1c4dB-3nepX:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 TRP A 519
ALA A 500
VAL A 503
 None
 0.96A 1c4dA-3o5aA:
undetectable
1c4dB-3o5aA:
undetectable		 1c4dA-3o5aA:
2.86
1c4dB-3o5aA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo3 OXY PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		3 TRP A 136
ALA A 134
VAL A 131
 None
 0.82A 1c4dA-3oo3A:
undetectable
1c4dB-3oo3A:
undetectable		 1c4dA-3oo3A:
3.83
1c4dB-3oo3A:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 3 TRP A 317
ALA A  94
VAL A 313
 None
 0.66A 1c4dA-3phfA:
undetectable
1c4dB-3phfA:
undetectable		 1c4dA-3phfA:
2.37
1c4dB-3phfA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 TRP A 644
ALA A 579
VAL A 608
 None
 0.93A 1c4dA-3s29A:
undetectable
1c4dB-3s29A:
undetectable		 1c4dA-3s29A:
3.51
1c4dB-3s29A:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9f TRYPAREDOXIN

(Leishmania
major) 		PF13905
(Thioredoxin_8) 		3 TRP A  70
ALA A  99
VAL A  97
 None
 0.95A 1c4dA-3s9fA:
undetectable
1c4dB-3s9fA:
undetectable		 1c4dA-3s9fA:
4.85
1c4dB-3s9fA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		3 TRP A 114
ALA A  30
VAL A  89
 None
 0.85A 1c4dA-3t95A:
undetectable
1c4dB-3t95A:
undetectable		 1c4dA-3t95A:
5.63
1c4dB-3t95A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty2 5'-NUCLEOTIDASE SURE

(Coxiella
burnetii) 		PF01975
(SurE) 		3 TRP A 112
ALA A 118
VAL A 111
 None
 0.93A 1c4dA-3ty2A:
undetectable
1c4dB-3ty2A:
undetectable		 1c4dA-3ty2A:
5.42
1c4dB-3ty2A:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		3 TRP A  86
ALA A 367
VAL A  81
 None
 0.79A 1c4dA-3vvlA:
undetectable
1c4dB-3vvlA:
undetectable		 1c4dA-3vvlA:
5.88
1c4dB-3vvlA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsv L-LACTATE
DEHYDROGENASE

(Enterococcus
mundtii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TRP A 133
ALA A 259
VAL A 143
 None
 0.87A 1c4dA-3wsvA:
undetectable
1c4dB-3wsvA:
undetectable		 1c4dA-3wsvA:
7.34
1c4dB-3wsvA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 TRP A1674
ALA A1616
VAL A1670
 None
 0.92A 1c4dA-4c6oA:
undetectable
1c4dB-4c6oA:
undetectable		 1c4dA-4c6oA:
4.36
1c4dB-4c6oA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		3 TRP A 272
ALA A 329
VAL A 327
 None
 0.89A 1c4dA-4ccdA:
undetectable
1c4dB-4ccdA:
undetectable		 1c4dA-4ccdA:
4.07
1c4dB-4ccdA:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 TRP A 200
ALA A  30
VAL A 196
 None
 0.87A 1c4dA-4lbwA:
undetectable
1c4dB-4lbwA:
undetectable		 1c4dA-4lbwA:
2.50
1c4dB-4lbwA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TRP A 133
ALA A 259
VAL A 143
 None
 0.80A 1c4dA-4ln1A:
undetectable
1c4dB-4ln1A:
undetectable		 1c4dA-4ln1A:
6.78
1c4dB-4ln1A:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E

(Butyrivibrio
proteoclasticus) 		PF04616
(Glyco_hydro_43) 		3 TRP A 205
ALA A 218
VAL A 216
 None
 0.94A 1c4dA-4novA:
undetectable
1c4dB-4novA:
undetectable		 1c4dA-4novA:
6.07
1c4dB-4novA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3i P DOMAIN OF VP1

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		3 TRP A 333
ALA A 384
VAL A 386
 None
 0.77A 1c4dA-4p3iA:
undetectable
1c4dB-4p3iA:
undetectable		 1c4dA-4p3iA:
3.07
1c4dB-4p3iA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE

(Pyrococcus
horikoshii) 		PF01916
(DS) 		3 TRP A 290
ALA A 297
VAL A 288
 None
 0.94A 1c4dA-4p63A:
undetectable
1c4dB-4p63A:
undetectable		 1c4dA-4p63A:
6.56
1c4dB-4p63A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Bacillus
anthracis) 		PF13407
(Peripla_BP_4) 		3 TRP A 121
ALA A  37
VAL A  96
 None
 0.88A 1c4dA-4pz0A:
undetectable
1c4dB-4pz0A:
undetectable		 1c4dA-4pz0A:
3.82
1c4dB-4pz0A:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0u RETINOIC ACID EARLY
TRANSCRIPT 1L
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I) 		3 TRP C  49
ALA C  51
VAL C  39
 None
 0.77A 1c4dA-4s0uC:
undetectable
1c4dB-4s0uC:
undetectable		 1c4dA-4s0uC:
6.96
1c4dB-4s0uC:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xoq COENZYME
F420:L-GLUTAMATE
LIGASE

(Mycobacterium
tuberculosis) 		PF00881
(Nitroreductase) 		3 TRP A 299
ALA A 425
VAL A 348
 None
 0.92A 1c4dA-4xoqA:
undetectable
1c4dB-4xoqA:
undetectable		 1c4dA-4xoqA:
13.89
1c4dB-4xoqA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 TRP A 285
ALA A 303
VAL A 298
 None
 0.89A 1c4dA-4xr9A:
undetectable
1c4dB-4xr9A:
undetectable		 1c4dA-4xr9A:
5.36
1c4dB-4xr9A:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfl AMIDOHYDROLASE EGTC

(Mycolicibacterium
smegmatis) 		PF13522
(GATase_6) 		3 TRP A  45
ALA A 102
VAL A  87
 None
 0.89A 1c4dA-4zflA:
undetectable
1c4dB-4zflA:
undetectable		 1c4dA-4zflA:
7.34
1c4dB-4zflA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjd AGGREGATION
SUPPRESSING PROTEIN

(Salmonella
enterica) 		PF00011
(HSP20) 		3 TRP A  63
ALA A  43
VAL A  60
 None
 0.90A 1c4dA-4zjdA:
undetectable
1c4dB-4zjdA:
undetectable		 1c4dA-4zjdA:
7.27
1c4dB-4zjdA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a24 DIONAIN-1

(Dionaea
muscipula) 		PF00112
(Peptidase_C1) 		3 TRP A   8
ALA A  34
VAL A 170
 None
 0.95A 1c4dA-5a24A:
undetectable
1c4dB-5a24A:
undetectable		 1c4dA-5a24A:
4.95
1c4dB-5a24A:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 TRP A 328
ALA A 434
VAL A 501
 None
 0.87A 1c4dA-5aorA:
undetectable
1c4dB-5aorA:
undetectable		 1c4dA-5aorA:
1.12
1c4dB-5aorA:
1.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3g PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 TRP B 528
ALA B 525
VAL B 388
 None
 0.88A 1c4dA-5b3gB:
undetectable
1c4dB-5b3gB:
undetectable		 1c4dA-5b3gB:
5.75
1c4dB-5b3gB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 TRP B 528
ALA B 525
VAL B 388
 None
 0.92A 1c4dA-5b3hB:
undetectable
1c4dB-5b3hB:
undetectable		 1c4dA-5b3hB:
5.75
1c4dB-5b3hB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2b SCFV 3B4 HEAVY CHAIN
3B4 LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		3 TRP L  34
ALA H 113
VAL L  35
 None
 0.96A 1c4dA-5c2bL:
undetectable
1c4dB-5c2bL:
undetectable		 1c4dA-5c2bL:
9.52
1c4dB-5c2bL:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		3 TRP A 167
ALA A 315
VAL A 252
 None
 0.90A 1c4dA-5dgqA:
undetectable
1c4dB-5dgqA:
undetectable		 1c4dA-5dgqA:
2.17
1c4dB-5dgqA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egw CYSTEINE PROTEASE

(Ambrosia
artemisiifolia) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 TRP A 137
ALA A 163
VAL A 294
 None
 0.95A 1c4dA-5egwA:
undetectable
1c4dB-5egwA:
undetectable		 1c4dA-5egwA:
2.86
1c4dB-5egwA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF03358
(FMN_red) 		3 TRP A 127
ALA A 161
VAL A 109
 None
 0.75A 1c4dA-5f12A:
undetectable
1c4dB-5f12A:
undetectable		 1c4dA-5f12A:
6.15
1c4dB-5f12A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		3 TRP A 278
ALA A 109
VAL A 133
 None
 0.93A 1c4dA-5fbbA:
undetectable
1c4dB-5fbbA:
undetectable		 1c4dA-5fbbA:
3.80
1c4dB-5fbbA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		3 TRP A 117
ALA A  92
VAL A 113
 None
 0.79A 1c4dA-5feiA:
undetectable
1c4dB-5feiA:
undetectable		 1c4dA-5feiA:
1.91
1c4dB-5feiA:
1.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 3 TRP Y 392
ALA Y 437
VAL Y 391
 None
 0.96A 1c4dA-5gaiY:
undetectable
1c4dB-5gaiY:
undetectable		 1c4dA-5gaiY:
1.89
1c4dB-5gaiY:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella ovis) 		PF13561
(adh_short_C2) 		3 TRP A 116
ALA A 105
VAL A 113
 None
 0.93A 1c4dA-5ha5A:
undetectable
1c4dB-5ha5A:
undetectable		 1c4dA-5ha5A:
6.08
1c4dB-5ha5A:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		3 TRP A 282
ALA A  10
VAL A  12
 None
 0.79A 1c4dA-5hosA:
undetectable
1c4dB-5hosA:
undetectable		 1c4dA-5hosA:
4.48
1c4dB-5hosA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 TRP A 399
ALA A 379
VAL A 381
 None
 0.85A 1c4dA-5jm7A:
undetectable
1c4dB-5jm7A:
undetectable		 1c4dA-5jm7A:
2.47
1c4dB-5jm7A:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbx OSMOLARITY
TWO-COMPONENT SYSTEM
PROTEIN SSK1

(Saccharomyces
cerevisiae) 		PF00072
(Response_reg) 		3 TRP B 543
ALA B 602
VAL B 604
 None
 0.95A 1c4dA-5kbxB:
undetectable
1c4dB-5kbxB:
undetectable		 1c4dA-5kbxB:
6.25
1c4dB-5kbxB:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj7 UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF01156
(IU_nuc_hydro) 		3 TRP A 202
ALA A 175
VAL A 166
 None
 0.92A 1c4dA-5mj7A:
undetectable
1c4dB-5mj7A:
undetectable		 1c4dA-5mj7A:
3.98
1c4dB-5mj7A:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		3 TRP A 267
ALA A 296
VAL A 266
 None
 0.94A 1c4dA-5n6mA:
undetectable
1c4dB-5n6mA:
undetectable		 1c4dA-5n6mA:
2.26
1c4dB-5n6mA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 TRP T2945
ALA T2951
VAL T2946
 None
 0.94A 1c4dA-5ojsT:
undetectable
1c4dB-5ojsT:
undetectable		 1c4dA-5ojsT:
0.58
1c4dB-5ojsT:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 TRP B 319
ALA B 479
VAL B 315
 None
 0.90A 1c4dA-5tteB:
undetectable
1c4dB-5tteB:
undetectable		 1c4dA-5tteB:
2.60
1c4dB-5tteB:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		3 TRP A 159
ALA A 307
VAL A 178
 None
 0.77A 1c4dA-5v1wA:
undetectable
1c4dB-5v1wA:
undetectable		 1c4dA-5v1wA:
2.37
1c4dB-5v1wA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA

(Mycobacterium
kansasii;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF14011
(ESX-1_EspG) 		3 TRP A 199
ALA A 220
VAL A 200
 None
 0.86A 1c4dA-5vbaA:
undetectable
1c4dB-5vbaA:
undetectable		 1c4dA-5vbaA:
3.28
1c4dB-5vbaA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 3 TRP A  27
ALA A  61
VAL A  23
 None
 0.94A 1c4dA-5x3hA:
undetectable
1c4dB-5x3hA:
undetectable		 1c4dA-5x3hA:
4.51
1c4dB-5x3hA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE

(Hydra vulgaris) 		no annotation 3 TRP A 235
ALA A 118
VAL A 130
 None
 0.89A 1c4dA-5xomA:
undetectable
1c4dB-5xomA:
undetectable		 1c4dA-5xomA:
undetectable
1c4dB-5xomA:
undetectable