SIMILAR PATTERNS OF AMINO ACIDS FOR 1C4D_A_DVAA8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		3 VAL A 140
TRP A 120
TRP A 160
 None
 1.31A 1c4dA-1ag9A:
undetectable
1c4dB-1ag9A:
undetectable		 1c4dA-1ag9A:
6.80
1c4dB-1ag9A:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		3 VAL B 155
TRP B 166
TRP B  65
 None
 1.17A 1c4dA-1cp9B:
undetectable
1c4dB-1cp9B:
undetectable		 1c4dA-1cp9B:
2.63
1c4dB-1cp9B:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czk FLAVODOXIN

(Synechococcus
elongatus) 		PF00258
(Flavodoxin_1) 		3 VAL A 139
TRP A 120
TRP A 159
 None
 1.13A 1c4dA-1czkA:
undetectable
1c4dB-1czkA:
undetectable		 1c4dA-1czkA:
6.31
1c4dB-1czkA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq7 NEUROTOXIN

(Mesobuthus
tamulus) 		PF00537
(Toxin_3) 		3 VAL A  45
TRP A  38
TRP A  39
 None
 1.24A 1c4dA-1dq7A:
undetectable
1c4dB-1dq7A:
undetectable		 1c4dA-1dq7A:
12.50
1c4dB-1dq7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 VAL A 145
TRP A 151
TRP A 219
 None
 1.27A 1c4dA-1ji6A:
undetectable
1c4dB-1ji6A:
undetectable		 1c4dA-1ji6A:
2.13
1c4dB-1ji6A:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ma1 SUPEROXIDE DISMUTASE

(Methanothermobacter
thermautotrophicus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 VAL A 153
TRP A 131
TRP A 168
 None
 1.43A 1c4dA-1ma1A:
undetectable
1c4dB-1ma1A:
undetectable		 1c4dA-1ma1A:
10.42
1c4dB-1ma1A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 VAL A 567
TRP A 251
TRP A 540
 None
 1.07A 1c4dA-1n21A:
undetectable
1c4dB-1n21A:
undetectable		 1c4dA-1n21A:
2.88
1c4dB-1n21A:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 3 VAL A 201
TRP A 353
TRP A 347
 None
 1.49A 1c4dA-1nluA:
undetectable
1c4dB-1nluA:
undetectable		 1c4dA-1nluA:
4.39
1c4dB-1nluA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4i ANTIBODY VARIABLE
HEAVY CHAIN
ANTIBODY VARIABLE
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		3 VAL H  41
TRP H  54
TRP L 137
 None
 1.29A 1c4dA-1p4iH:
undetectable
1c4dB-1p4iH:
undetectable		 1c4dA-1p4iH:
11.65
1c4dB-1p4iH:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4i ANTIBODY VARIABLE
HEAVY CHAIN
ANTIBODY VARIABLE
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		3 VAL H  41
TRP L 137
TRP H  54
 None
 1.29A 1c4dA-1p4iH:
undetectable
1c4dB-1p4iH:
undetectable		 1c4dA-1p4iH:
11.65
1c4dB-1p4iH:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		3 VAL A 561
TRP A 555
TRP A 564
 None
 1.33A 1c4dA-1pxyA:
undetectable
1c4dB-1pxyA:
undetectable		 1c4dA-1pxyA:
3.28
1c4dB-1pxyA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE III

(Paracoccus
denitrificans) 		PF00510
(COX3) 		3 VAL C  70
TRP C  65
TRP C  16
 PC1  C 302 (-4.3A)
None
None
 1.32A 1c4dA-1qleC:
undetectable
1c4dB-1qleC:
undetectable		 1c4dA-1qleC:
5.53
1c4dB-1qleC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF01323
(DSBA) 		3 VAL A 117
TRP A  20
TRP A 122
 None
 1.30A 1c4dA-1r4wA:
undetectable
1c4dB-1r4wA:
undetectable		 1c4dA-1r4wA:
4.65
1c4dB-1r4wA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		3 VAL A  85
TRP A  22
TRP A  14
 None
 1.14A 1c4dA-1w8jA:
undetectable
1c4dB-1w8jA:
undetectable		 1c4dA-1w8jA:
3.07
1c4dB-1w8jA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii) 		PF00258
(Flavodoxin_1) 		3 VAL A 147
TRP A 128
TRP A 167
 None
 1.21A 1c4dA-1yobA:
undetectable
1c4dB-1yobA:
undetectable		 1c4dA-1yobA:
15.00
1c4dB-1yobA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		3 VAL A 319
TRP A 263
TRP A 261
 None
 1.47A 1c4dA-2bexA:
undetectable
1c4dB-2bexA:
undetectable		 1c4dA-2bexA:
3.42
1c4dB-2bexA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		3 VAL A  79
TRP A  81
TRP A 294
 None
 1.47A 1c4dA-2c1cA:
undetectable
1c4dB-2c1cA:
undetectable		 1c4dA-2c1cA:
3.89
1c4dB-2c1cA:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 VAL A  85
TRP A  22
TRP A  14
 None
 1.04A 1c4dA-2dfsA:
undetectable
1c4dB-2dfsA:
undetectable		 1c4dA-2dfsA:
1.59
1c4dB-2dfsA:
1.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6r BIFUNCTIONAL
COENZYME A SYNTHASE

(Mus musculus) 		PF01121
(CoaE) 		3 VAL A 152
TRP A 150
TRP A 184
 None
ACO  A 270 (-3.9A)
ACO  A 270 (-4.2A)
 1.09A 1c4dA-2f6rA:
undetectable
1c4dB-2f6rA:
undetectable		 1c4dA-2f6rA:
3.70
1c4dB-2f6rA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 115
TRP A 105
TRP A  88
 None
 1.04A 1c4dA-2iwiA:
undetectable
1c4dB-2iwiA:
undetectable		 1c4dA-2iwiA:
5.41
1c4dB-2iwiA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 VAL A 247
TRP A 245
TRP A 533
 None
 1.30A 1c4dA-2j5cA:
undetectable
1c4dB-2j5cA:
undetectable		 1c4dA-2j5cA:
4.51
1c4dB-2j5cA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9l BETA-THERAPHOTOXIN-T
P1A

(Thrixopelma
pruriens) 		PF07740
(Toxin_12) 		3 VAL A  20
TRP A   5
TRP A  30
 None
 1.40A 1c4dA-2m9lA:
undetectable
1c4dB-2m9lA:
undetectable		 1c4dA-2m9lA:
14.29
1c4dB-2m9lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt9 FLAVODOXIN-2

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		3 VAL A 140
TRP A 119
TRP A 160
 None
 1.01A 1c4dA-2mt9A:
undetectable
1c4dB-2mt9A:
undetectable		 1c4dA-2mt9A:
8.77
1c4dB-2mt9A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ncm NEURAL CELL ADHESION
MOLECULE

(Mus musculus) 		PF07679
(I-set) 		3 VAL A  81
TRP A  56
TRP A  37
 None
 1.34A 1c4dA-2ncmA:
undetectable
1c4dB-2ncmA:
undetectable		 1c4dA-2ncmA:
9.52
1c4dB-2ncmA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaf THIOESTERASE
SUPERFAMILY

(Jannaschia sp.
CCS1) 		PF03061
(4HBT) 		3 VAL A 117
TRP A  52
TRP A  43
 None
 1.19A 1c4dA-2oafA:
undetectable
1c4dB-2oafA:
undetectable		 1c4dA-2oafA:
10.42
1c4dB-2oafA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opk HYPOTHETICAL PROTEIN

(Cupriavidus
pinatubonensis) 		PF07883
(Cupin_2) 		3 VAL A  58
TRP A  81
TRP A  55
 None
 1.04A 1c4dA-2opkA:
undetectable
1c4dB-2opkA:
undetectable		 1c4dA-2opkA:
13.98
1c4dB-2opkA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opk HYPOTHETICAL PROTEIN

(Cupriavidus
pinatubonensis) 		PF07883
(Cupin_2) 		3 VAL A  84
TRP A  55
TRP A  81
 None
 1.26A 1c4dA-2opkA:
undetectable
1c4dB-2opkA:
undetectable		 1c4dA-2opkA:
13.98
1c4dB-2opkA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 VAL A 594
TRP A 560
TRP A 548
 None
 1.30A 1c4dA-2vcaA:
undetectable
1c4dB-2vcaA:
undetectable		 1c4dA-2vcaA:
2.28
1c4dB-2vcaA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 VAL A 358
TRP A 360
TRP A 406
 None
 1.44A 1c4dA-2vr2A:
undetectable
1c4dB-2vr2A:
undetectable		 1c4dA-2vr2A:
3.33
1c4dB-2vr2A:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak1 SUPEROXIDE DISMUTASE
[MN/FE]

(Aeropyrum
pernix) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 VAL A 152
TRP A 130
TRP A 167
 None
 1.43A 1c4dA-3ak1A:
undetectable
1c4dB-3ak1A:
undetectable		 1c4dA-3ak1A:
5.14
1c4dB-3ak1A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		3 VAL A 175
TRP A 173
TRP A  54
 None
 1.35A 1c4dA-3bitA:
undetectable
1c4dB-3bitA:
undetectable		 1c4dA-3bitA:
5.83
1c4dB-3bitA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byh FIMBRIN ABD2

(Homo sapiens) 		PF00307
(CH) 		3 VAL B 561
TRP B 555
TRP B 564
 None
 1.33A 1c4dA-3byhB:
undetectable
1c4dB-3byhB:
undetectable		 1c4dA-3byhB:
5.22
1c4dB-3byhB:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		3 VAL A 105
TRP A 197
TRP A  83
 None
 0.92A 1c4dA-3fw6A:
undetectable
1c4dB-3fw6A:
undetectable		 1c4dA-3fw6A:
3.95
1c4dB-3fw6A:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS

(Bordetella
bronchiseptica) 		no annotation 3 VAL A 203
TRP A 153
TRP A 176
 None
 1.40A 1c4dA-3hftA:
undetectable
1c4dB-3hftA:
undetectable		 1c4dA-3hftA:
9.45
1c4dB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE

(Homo sapiens) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 VAL A 140
TRP A 229
TRP A 219
 None
 1.29A 1c4dA-3hy8A:
undetectable
1c4dB-3hy8A:
undetectable		 1c4dA-3hy8A:
3.94
1c4dB-3hy8A:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4s HISTIDINE TRIAD
PROTEIN

(Bradyrhizobium
japonicum) 		PF01230
(HIT) 		3 VAL A 128
TRP A  70
TRP A 145
 None
 1.08A 1c4dA-3i4sA:
undetectable
1c4dB-3i4sA:
undetectable		 1c4dA-3i4sA:
6.34
1c4dB-3i4sA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		3 VAL A 398
TRP A 401
TRP A 402
 None
 1.45A 1c4dA-3icjA:
undetectable
1c4dB-3icjA:
undetectable		 1c4dA-3icjA:
4.72
1c4dB-3icjA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN

(Homo sapiens;
Mus musculus;
Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 VAL B  34
TRP B  47
TRP A  96
 None
 1.23A 1c4dA-3mnzB:
undetectable
1c4dB-3mnzB:
undetectable		 1c4dA-3mnzB:
4.21
1c4dB-3mnzB:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 VAL A 478
TRP A 480
TRP A  12
 None
 1.44A 1c4dA-3rcnA:
undetectable
1c4dB-3rcnA:
undetectable		 1c4dA-3rcnA:
3.88
1c4dB-3rcnA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Bacillus
anthracis) 		PF00908
(dTDP_sugar_isom) 		3 VAL A 146
TRP A 148
TRP A 157
 None
 1.24A 1c4dA-3rykA:
undetectable
1c4dB-3rykA:
undetectable		 1c4dA-3rykA:
6.98
1c4dB-3rykA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6o SULFATE
TRANSPORTER/ANTISIGM
A-FACTOR ANTAGONIST
STAS

(Planctopirus
limnophila) 		no annotation 3 VAL A  48
TRP A  70
TRP A 103
 None
 1.42A 1c4dA-3t6oA:
undetectable
1c4dB-3t6oA:
undetectable		 1c4dA-3t6oA:
17.95
1c4dB-3t6oA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzv ANTI-DENGUE MAB 4E11

(Mus musculus) 		PF07686
(V-set) 		3 VAL B 161
TRP B 232
TRP B 101
 None
 1.38A 1c4dA-3uzvB:
undetectable
1c4dB-3uzvB:
undetectable		 1c4dA-3uzvB:
9.90
1c4dB-3uzvB:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa8 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Meiothermus
ruber) 		PF09485
(CRISPR_Cse2) 		3 VAL A  73
TRP A  69
TRP A 159
 None
 1.33A 1c4dA-3wa8A:
undetectable
1c4dB-3wa8A:
undetectable		 1c4dA-3wa8A:
7.38
1c4dB-3wa8A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 VAL A 357
TRP A 359
TRP A 405
 None
 1.43A 1c4dA-4b90A:
undetectable
1c4dB-4b90A:
undetectable		 1c4dA-4b90A:
3.52
1c4dB-4b90A:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 VAL A 357
TRP A 359
TRP A 405
 None
 1.40A 1c4dA-4b92A:
undetectable
1c4dB-4b92A:
undetectable		 1c4dA-4b92A:
3.52
1c4dB-4b92A:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 VAL A 364
TRP A 366
TRP A 412
 None
 1.43A 1c4dA-4cnsA:
undetectable
1c4dB-4cnsA:
undetectable		 1c4dA-4cnsA:
4.08
1c4dB-4cnsA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 VAL A 364
TRP A 366
TRP A 412
 None
 1.44A 1c4dA-4cntA:
undetectable
1c4dB-4cntA:
undetectable		 1c4dA-4cntA:
4.08
1c4dB-4cntA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  56
TRP A  38
TRP A 386
 None
 1.48A 1c4dA-4gi2A:
undetectable
1c4dB-4gi2A:
undetectable		 1c4dA-4gi2A:
5.09
1c4dB-4gi2A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz7 DIHYDROPYRIMIDINASE

(Tetraodon
nigroviridis) 		PF01979
(Amidohydro_1) 		3 VAL A 354
TRP A 356
TRP A 402
 None
 1.45A 1c4dA-4gz7A:
undetectable
1c4dB-4gz7A:
undetectable		 1c4dA-4gz7A:
4.44
1c4dB-4gz7A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		3 VAL A 193
TRP A 188
TRP A 191
 None
 0.91A 1c4dA-4igmA:
undetectable
1c4dB-4igmA:
undetectable		 1c4dA-4igmA:
5.88
1c4dB-4igmA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		3 VAL A 193
TRP A 191
TRP A 188
 None
 1.19A 1c4dA-4igmA:
undetectable
1c4dB-4igmA:
undetectable		 1c4dA-4igmA:
5.88
1c4dB-4igmA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		3 VAL A 200
TRP A 205
TRP A 236
 None
 1.02A 1c4dA-4k5yA:
undetectable
1c4dB-4k5yA:
undetectable		 1c4dA-4k5yA:
5.15
1c4dB-4k5yA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		3 VAL A 238
TRP A 236
TRP A 205
 OLA  A 501 ( 4.2A)
None
None
 1.07A 1c4dA-4k5yA:
undetectable
1c4dB-4k5yA:
undetectable		 1c4dA-4k5yA:
5.15
1c4dB-4k5yA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kha SPT16M-HISTONE H2B
1.1 CHIMERA

(Xenopus laevis;
Chaetomium
thermophilum) 		PF00125
(Histone)
PF08512
(Rtt106)
PF08644
(SPT16) 		3 VAL A 873
TRP A 857
TRP A 937
 None
 1.37A 1c4dA-4khaA:
undetectable
1c4dB-4khaA:
undetectable		 1c4dA-4khaA:
2.46
1c4dB-4khaA:
2.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		3 VAL A 156
TRP A 151
TRP A 315
 IMD  A 705 ( 4.6A)
None
None
 1.47A 1c4dA-4kvlA:
undetectable
1c4dB-4kvlA:
undetectable		 1c4dA-4kvlA:
2.96
1c4dB-4kvlA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzi MULTICYSTATIN

(Solanum
tuberosum) 		PF00031
(Cystatin) 		3 VAL A  50
TRP A 174
TRP A  76
 None
 1.31A 1c4dA-4lziA:
undetectable
1c4dB-4lziA:
undetectable		 1c4dA-4lziA:
4.69
1c4dB-4lziA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome) 		PF00150
(Cellulase) 		3 VAL A  44
TRP A  46
TRP A 276
 None
 1.23A 1c4dA-4m1rA:
undetectable
1c4dB-4m1rA:
undetectable		 1c4dA-4m1rA:
4.56
1c4dB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		3 VAL A 525
TRP A 537
TRP A 242
 None
 1.33A 1c4dA-4madA:
undetectable
1c4dB-4madA:
undetectable		 1c4dA-4madA:
2.95
1c4dB-4madA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 VAL A 260
TRP A 258
TRP A 180
 ST9  A 403 (-4.4A)
ST9  A 403 (-4.2A)
None
 1.13A 1c4dA-4ymkA:
undetectable
1c4dB-4ymkA:
undetectable		 1c4dA-4ymkA:
8.89
1c4dB-4ymkA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfq L,D-TRANSPEPTIDASE 5

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		3 VAL A 408
TRP A 206
TRP A 220
 None
None
PEG  A 501 ( 4.8A)
 1.42A 1c4dA-4zfqA:
undetectable
1c4dB-4zfqA:
undetectable		 1c4dA-4zfqA:
3.82
1c4dB-4zfqA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 3 VAL A 264
TRP A 262
TRP A 184
 ST9  A 403 (-4.8A)
ST9  A 403 (-4.2A)
None
 1.10A 1c4dA-4zyoA:
undetectable
1c4dB-4zyoA:
undetectable		 1c4dA-4zyoA:
4.47
1c4dB-4zyoA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		3 VAL C 313
TRP C 272
TRP C 378
 None
 1.21A 1c4dA-5aa5C:
undetectable
1c4dB-5aa5C:
undetectable		 1c4dA-5aa5C:
3.78
1c4dB-5aa5C:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		3 VAL C 313
TRP C 378
TRP C 272
 None
 1.44A 1c4dA-5aa5C:
undetectable
1c4dB-5aa5C:
undetectable		 1c4dA-5aa5C:
3.78
1c4dB-5aa5C:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aam SCFV513

(Mus musculus) 		PF07686
(V-set) 		3 VAL A 161
TRP A 232
TRP A 100
 None
 1.41A 1c4dA-5aamA:
undetectable
1c4dB-5aamA:
undetectable		 1c4dA-5aamA:
3.60
1c4dB-5aamA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3g PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 VAL B 225
TRP B 234
TRP B 425
 None
 1.30A 1c4dA-5b3gB:
undetectable
1c4dB-5b3gB:
undetectable		 1c4dA-5b3gB:
5.75
1c4dB-5b3gB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czd ACYL-CARRIER-PROTEIN

(Streptomyces
halstedii) 		PF00550
(PP-binding) 		3 VAL B  69
TRP B  71
TRP B   2
 None
 1.06A 1c4dA-5czdB:
undetectable
1c4dB-5czdB:
undetectable		 1c4dA-5czdB:
8.86
1c4dB-5czdB:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 VAL A 553
TRP A 520
TRP A 505
 None
 1.18A 1c4dA-5f7cA:
undetectable
1c4dB-5f7cA:
undetectable		 1c4dA-5f7cA:
3.94
1c4dB-5f7cA:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		3 VAL A  83
TRP A  22
TRP A  14
 None
 1.12A 1c4dA-5hmpA:
undetectable
1c4dB-5hmpA:
undetectable		 1c4dA-5hmpA:
2.28
1c4dB-5hmpA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Paraburkholderia
phymatum) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 VAL A  52
TRP A  60
TRP A  31
 None
 1.30A 1c4dA-5iduA:
undetectable
1c4dB-5iduA:
undetectable		 1c4dA-5iduA:
4.91
1c4dB-5iduA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		3 VAL A  71
TRP A  73
TRP A 303
 None
 1.24A 1c4dA-5ihsA:
undetectable
1c4dB-5ihsA:
undetectable		 1c4dA-5ihsA:
4.71
1c4dB-5ihsA:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijv BOVINE FAB E03 HEAVY
CHAIN

(Bos taurus) 		no annotation 3 VAL H  34
TRP H  47
TRP H 134
 None
 0.94A 1c4dA-5ijvH:
undetectable
1c4dB-5ijvH:
undetectable		 1c4dA-5ijvH:
5.39
1c4dB-5ijvH:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijv BOVINE FAB E03 HEAVY
CHAIN

(Bos taurus) 		no annotation 3 VAL H  34
TRP H 134
TRP H  47
 None
 1.33A 1c4dA-5ijvH:
undetectable
1c4dB-5ijvH:
undetectable		 1c4dA-5ijvH:
5.39
1c4dB-5ijvH:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsc PUTATIVE ACYL-COA
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 VAL A  53
TRP A  61
TRP A  32
 None
 1.27A 1c4dA-5jscA:
undetectable
1c4dB-5jscA:
undetectable		 1c4dA-5jscA:
4.10
1c4dB-5jscA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 3 VAL B  21
TRP B  19
TRP B  12
 None
 1.44A 1c4dA-5khnB:
undetectable
1c4dB-5khnB:
undetectable		 1c4dA-5khnB:
2.12
1c4dB-5khnB:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhr CAMELID-DERIVED
ANTIBODY FRAGMENT
NB22

(Vicugna pacos) 		PF07686
(V-set) 		3 VAL B  48
TRP B 111
TRP B 109
 None
 0.86A 1c4dA-5lhrB:
undetectable
1c4dB-5lhrB:
undetectable		 1c4dA-5lhrB:
5.76
1c4dB-5lhrB:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 VAL A 813
TRP A 821
TRP A1009
 None
 1.43A 1c4dA-5mzaA:
undetectable
1c4dB-5mzaA:
undetectable		 1c4dA-5mzaA:
6.76
1c4dB-5mzaA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR

(Homo sapiens) 		PF00002
(7tm_2)
PF02793
(HRM) 		3 VAL A 276
TRP A 274
TRP A 243
 None
 1.24A 1c4dA-5nx2A:
undetectable
1c4dB-5nx2A:
undetectable		 1c4dA-5nx2A:
4.45
1c4dB-5nx2A:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocd -

(-) 		no annotation 3 VAL A  63
TRP A 117
TRP A 187
 None
 1.13A 1c4dA-5ocdA:
undetectable
1c4dB-5ocdA:
undetectable		 1c4dA-5ocdA:
undetectable
1c4dB-5ocdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oee LARGE SUBUNIT
TERMINASE

(Phage D6E) 		no annotation 3 VAL A  50
TRP A  24
TRP A  25
 None
 1.33A 1c4dA-5oeeA:
undetectable
1c4dB-5oeeA:
undetectable		 1c4dA-5oeeA:
3.94
1c4dB-5oeeA:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th3 R-SWAI PROTEIN

(Staphylococcus
warneri) 		no annotation 3 VAL A 126
TRP A  91
TRP A  75
 None
 1.45A 1c4dA-5th3A:
undetectable
1c4dB-5th3A:
undetectable		 1c4dA-5th3A:
5.52
1c4dB-5th3A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj5 V-TYPE PROTON ATPASE
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF01496
(V_ATPase_I) 		3 VAL A 749
TRP A 777
TRP A 751
 None
 1.27A 1c4dA-5tj5A:
undetectable
1c4dB-5tj5A:
undetectable		 1c4dA-5tj5A:
5.79
1c4dB-5tj5A:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 VAL A 364
TRP A 366
TRP A 412
 None
 1.40A 1c4dA-5uqcA:
undetectable
1c4dB-5uqcA:
undetectable		 1c4dA-5uqcA:
6.01
1c4dB-5uqcA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux9 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Aliivibrio
fischeri) 		PF00132
(Hexapep) 		3 VAL A 182
TRP A 185
TRP A 188
 None
 1.23A 1c4dA-5ux9A:
undetectable
1c4dB-5ux9A:
undetectable		 1c4dA-5ux9A:
5.45
1c4dB-5ux9A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vai UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF00002
(7tm_2)
PF02793
(HRM) 		3 VAL R 276
TRP R 274
TRP R 243
 None
 1.28A 1c4dA-5vaiR:
undetectable
1c4dB-5vaiR:
undetectable		 1c4dA-5vaiR:
3.15
1c4dB-5vaiR:
3.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		3 VAL A 276
TRP A 274
TRP A 243
 None
 1.30A 1c4dA-5vewA:
undetectable
1c4dB-5vewA:
undetectable		 1c4dA-5vewA:
3.08
1c4dB-5vewA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji 16KDA MEMBRANE
PROTEIN

(Zea mays) 		no annotation 3 VAL O 100
TRP O  56
TRP O 102
 None
 1.43A 1c4dA-5zjiO:
undetectable
1c4dB-5zjiO:
undetectable		 1c4dA-5zjiO:
undetectable
1c4dB-5zjiO:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji 16KDA MEMBRANE
PROTEIN

(Zea mays) 		no annotation 3 VAL O 100
TRP O 102
TRP O  56
 None
 1.11A 1c4dA-5zjiO:
undetectable
1c4dB-5zjiO:
undetectable		 1c4dA-5zjiO:
undetectable
1c4dB-5zjiO:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 3 VAL A 176
TRP A 174
TRP A  55
 None
 1.24A 1c4dA-6a8mA:
undetectable
1c4dB-6a8mA:
undetectable		 1c4dA-6a8mA:
undetectable
1c4dB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		no annotation
no annotation 		3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.39A 1c4dA-6cxhA:
undetectable
1c4dB-6cxhA:
undetectable		 1c4dA-6cxhA:
undetectable
1c4dB-6cxhA:
undetectable