SIMILAR PATTERNS OF AMINO ACIDS FOR 1BZM_A_MZMA262

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		4 HIS A  61
HIS A  44
HIS A  69
HIS A 118
 ZN  A 501 ( 3.2A)
CU  A 502 (-3.3A)
ZN  A 501 (-2.9A)
CU  A 502 (-3.1A)
 0.95A 1bzmA-1eqwA:
undetectable		 1bzmA-1eqwA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 384
HIS A 344
HIS A 224
HIS A 348
 CU  A 666 (-3.4A)
CU  A 666 (-3.1A)
CU  A 665 (-3.5A)
CU  A 666 (-3.8A)
 0.92A 1bzmA-1hcyA:
undetectable		 1bzmA-1hcyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 401
HIS A  64
HIS A 451
 CU  A 702 (-3.2A)
CU  A 702 (-3.2A)
CU  A 703 (-4.7A)
CU  A 702 (-3.2A)
 0.99A 1bzmA-1hfuA:
undetectable		 1bzmA-1hfuA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
None
 0.18A 1bzmA-1jd0A:
35.3		 1bzmA-1jd0A:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 HIS A  92
HIS A  94
HIS A 111
LEU A 176
THR A 177
TRP A 187
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
None
 0.35A 1bzmA-1kopA:
29.8		 1bzmA-1kopA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 364
HIS A 324
HIS A 204
HIS A 328
 CU  A 630 (-3.0A)
CU  A 630 (-3.3A)
CU  A 629 (-3.1A)
CU  A 630 (-3.2A)
 1.00A 1bzmA-1llaA:
undetectable		 1bzmA-1llaA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A  70
HIS A 212
HIS A 181
LEU A 199
HIS A  41
 CU  A5001 ( 3.1A)
CU  A5012 (-3.1A)
CU  A5012 (-3.4A)
None
CU  A5001 (-2.9A)
 1.26A 1bzmA-1lnlA:
undetectable		 1bzmA-1lnlA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oal SUPEROXIDE DISMUTASE

(Photobacterium
leiognathi) 		PF00080
(Sod_Cu) 		4 HIS A  70
HIS A  45
HIS A  79
HIS A 125
 ZN  A 152 ( 3.1A)
CU  A 153 (-3.0A)
ZN  A 152 (-3.1A)
CU  A 153 (-3.2A)
 0.97A 1bzmA-1oalA:
undetectable		 1bzmA-1oalA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
None
 0.31A 1bzmA-1rj6A:
35.9		 1bzmA-1rj6A:
35.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 HIS A 277
HIS A 263
THR A 199
HIS A 200
 ZN  A 387 (-3.3A)
ZN  A 387 ( 3.3A)
None
ZN  A 387 ( 3.3A)
 0.94A 1bzmA-1rrmA:
undetectable		 1bzmA-1rrmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to5 SUPEROXIDE DISMUTASE

(Schistosoma
mansoni) 		PF00080
(Sod_Cu) 		4 HIS A  62
HIS A  45
HIS A  70
HIS A 119
 ZN  A 711 ( 3.1A)
CU  A 712 (-3.3A)
ZN  A 711 (-3.1A)
CU  A 712 (-3.2A)
 0.97A 1bzmA-1to5A:
undetectable		 1bzmA-1to5A:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
 0.27A 1bzmA-1urtA:
36.4		 1bzmA-1urtA:
44.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		6 HIS A 115
HIS A 117
HIS A 135
LEU A 216
THR A 217
TRP A 227
 ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ZN  A 283 ( 3.1A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
None
 0.19A 1bzmA-1y7wA:
25.3		 1bzmA-1y7wA:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 HIS A  95
HIS A  70
HIS A 104
HIS A 151
 ZN  A 201 ( 3.1A)
CU  A 200 (-3.1A)
ZN  A 201 (-3.1A)
CU  A 200 (-3.2A)
 0.94A 1bzmA-1z9nA:
undetectable		 1bzmA-1z9nA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 HIS A  95
HIS A  70
HIS A 104
HIS A 151
 ZN  A 201 ( 3.1A)
CU  A 200 (-3.1A)
ZN  A 201 (-3.1A)
CU  A 200 (-3.2A)
 0.94A 1bzmA-1z9pA:
undetectable		 1bzmA-1z9pA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		4 HIS A  85
HIS A  60
HIS A  94
HIS A 141
 ZN  A 400 (-3.2A)
CU  A 402 ( 3.3A)
ZN  A 400 ( 3.1A)
CU  A 402 ( 3.1A)
 0.92A 1bzmA-2apsA:
undetectable		 1bzmA-2apsA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]

(Neisseria
meningitidis) 		no annotation 4 HIS C 104
HIS C  79
HIS C 113
HIS C 160
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.1A)
ZN  C 201 (-3.2A)
CU1  C 200 (-3.2A)
 0.93A 1bzmA-2aqtC:
undetectable		 1bzmA-2aqtC:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		4 PHE A 233
HIS A 251
LEU A 370
THR A 369
 None
 0.98A 1bzmA-2b0tA:
undetectable		 1bzmA-2b0tA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		4 PHE D 324
HIS D 320
LEU D 282
THR D 279
 None
 0.76A 1bzmA-2gafD:
undetectable		 1bzmA-2gafD:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		4 HIS A 229
HIS A  73
HIS A 269
HIS A  75
 GUN  A 503 ( 3.5A)
FE  A 501 (-3.4A)
GUN  A 503 ( 4.4A)
FE  A 501 ( 3.6A)
 0.99A 1bzmA-2i9uA:
undetectable		 1bzmA-2i9uA:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 PHE A  91
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
HIS A 200
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
PPF  A 500 (-3.9A)
None
 0.44A 1bzmA-2it4A:
44.3		 1bzmA-2it4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 HIS A  78
HIS A  76
HIS A 137
HIS A 285
 ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
None
ZN  A 493 (-3.5A)
 0.90A 1bzmA-2pajA:
undetectable		 1bzmA-2pajA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peb PUTATIVE DIOXYGENASE

(Nostoc
punctiforme) 		PF08883
(DOPA_dioxygen) 		4 PHE A  44
HIS A  14
HIS A  84
HIS A  12
 None
ZN  A 200 ( 3.1A)
ZN  A 200 ( 3.4A)
ZN  A 200 ( 3.1A)
 0.95A 1bzmA-2pebA:
undetectable		 1bzmA-2pebA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph0 UNCHARACTERIZED
PROTEIN

(Pectobacterium
carotovorum) 		PF06228
(ChuX_HutX) 		4 PHE A 126
HIS A  66
LEU A  17
THR A  16
 None
 0.93A 1bzmA-2ph0A:
undetectable		 1bzmA-2ph0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		4 HIS A 237
HIS A 235
HIS A 255
LEU A 202
 MET  A 600 (-3.9A)
MET  A 600 (-4.4A)
MET  A 600 ( 4.3A)
MET  A 600 (-3.7A)
 0.80A 1bzmA-2qs8A:
undetectable		 1bzmA-2qs8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		4 HIS A 255
HIS A 237
HIS A 235
LEU A 202
 MET  A 600 ( 4.3A)
MET  A 600 (-3.9A)
MET  A 600 (-4.4A)
MET  A 600 (-3.7A)
 0.97A 1bzmA-2qs8A:
undetectable		 1bzmA-2qs8A:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 118
HIS A 141
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
 0.26A 1bzmA-2w2jA:
35.0		 1bzmA-2w2jA:
37.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwo SUPEROXIDE DISMUTASE
[CU-ZN]

(Yersinia
pseudotuberculosis) 		PF00080
(Sod_Cu) 		4 HIS A  79
HIS A  54
HIS A  88
HIS A 135
 ZN  A1162 ( 3.2A)
ZN  A1165 (-3.3A)
ZN  A1162 (-3.2A)
ZN  A1165 (-3.3A)
 0.97A 1bzmA-2wwoA:
undetectable		 1bzmA-2wwoA:
23.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
ZN  A   1 ( 4.7A)
None
 0.30A 1bzmA-2zncA:
29.9		 1bzmA-2zncA:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 163
HIS A 165
HIS A 182
LEU A 259
THR A 260
TRP A 270
 ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 (-3.1A)
None
ZN  A 378 ( 4.5A)
None
 0.19A 1bzmA-3b1bA:
24.6		 1bzmA-3b1bA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 PHE A 820
HIS A 653
THR A 621
HIS A 617
 VDN  A   1 (-3.6A)
None
None
None
 0.97A 1bzmA-3b2rA:
undetectable		 1bzmA-3b2rA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		4 HIS A 281
HIS A 267
THR A 201
HIS A 202
 FE2  A1388 (-3.6A)
FE2  A1388 (-3.2A)
None
FE2  A1388 (-3.4A)
 0.96A 1bzmA-3bfjA:
undetectable		 1bzmA-3bfjA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 PHE A 820
HIS A 653
THR A 621
HIS A 617
 WAN  A 901 (-3.7A)
ZN  A 876 (-3.3A)
None
ZN  A 876 (-3.3A)
 0.94A 1bzmA-3bjcA:
undetectable		 1bzmA-3bjcA:
13.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  95
HIS A  97
HIS A 120
LEU A 199
THR A 200
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 0.50A 1bzmA-3da2A:
42.1		 1bzmA-3da2A:
59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 PHE A 132
HIS A  95
HIS A  97
LEU A 199
THR A 200
TRP A 210
 4MD  A 401 (-4.6A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 1.00A 1bzmA-3da2A:
42.1		 1bzmA-3da2A:
59.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 140
HIS A 436
HIS A  93
HIS A 502
 CU  A 602 ( 3.3A)
CU  A 602 (-3.2A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
 1.00A 1bzmA-3dkhA:
undetectable		 1bzmA-3dkhA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 HIS A 238
HIS A  82
HIS A 277
HIS A  84
 ZN  A1452 (-3.2A)
ZN  A1452 (-3.3A)
None
ZN  A1452 (-3.1A)
 1.00A 1bzmA-3e0lA:
undetectable		 1bzmA-3e0lA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 111
HIS A 113
HIS A 138
LEU A 219
THR A 220
TRP A 230
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
 0.63A 1bzmA-3fe4A:
30.3		 1bzmA-3fe4A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 HIS A  63
HIS A  61
HIS A 122
HIS A 246
 FE  A 502 (-3.1A)
FE  A 502 (-3.1A)
None
FE  A 502 ( 4.8A)
 0.85A 1bzmA-3g77A:
undetectable		 1bzmA-3g77A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 HIS A 259
HIS A  93
HIS A 296
HIS A  95
 ZN  A 480 (-3.5A)
ZN  A 480 (-3.3A)
ZN  A 480 ( 4.8A)
ZN  A 480 (-3.3A)
 1.01A 1bzmA-3hpaA:
undetectable		 1bzmA-3hpaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht1 REMF PROTEIN

(Streptomyces
resistomycificus) 		PF07883
(Cupin_2) 		4 PHE A 107
HIS A  59
HIS A  55
HIS A  53
 None
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
 0.97A 1bzmA-3ht1A:
undetectable		 1bzmA-3ht1A:
24.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 129
LEU A 235
THR A 236
TRP A 246
 None
 0.27A 1bzmA-3jxfA:
32.8		 1bzmA-3jxfA:
31.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 166
HIS A 129
THR A 236
TRP A 246
 None
 0.81A 1bzmA-3jxfA:
32.8		 1bzmA-3jxfA:
31.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9y SUPEROXIDE DISMUTASE
[CU-ZN]

(Bombyx mori) 		PF00080
(Sod_Cu) 		4 HIS A  62
HIS A  45
HIS A  70
HIS A 120
 ZN  A 155 ( 3.1A)
CU  A 156 (-3.2A)
ZN  A 155 (-3.2A)
CU  A 156 (-3.1A)
 0.99A 1bzmA-3l9yA:
undetectable		 1bzmA-3l9yA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 HIS A 238
HIS A 274
THR A 325
HIS A  63
 ZN  A 458 (-3.2A)
AOO  A 457 ( 4.6A)
AOO  A 457 (-4.0A)
ZN  A 458 (-3.3A)
 0.85A 1bzmA-3lscA:
undetectable		 1bzmA-3lscA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
None
 0.21A 1bzmA-3ml5A:
40.1		 1bzmA-3ml5A:
50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 131
HIS A  96
THR A 199
TRP A 209
 AZM  A 264 (-4.4A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
None
 0.80A 1bzmA-3ml5A:
40.1		 1bzmA-3ml5A:
50.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 HIS A 277
HIS A 263
THR A 197
HIS A 198
 NAD  A1385 ( 3.6A)
FE2  A 501 (-3.3A)
None
FE2  A 501 (-3.3A)
 0.89A 1bzmA-3ox4A:
undetectable		 1bzmA-3ox4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pao ADENOSINE DEAMINASE

(Pseudomonas
aeruginosa) 		PF00962
(A_deaminase) 		4 HIS A 196
HIS A  16
HIS A 220
HIS A  18
 ZN  A 327 ( 3.5A)
ZN  A 327 (-3.4A)
ADE  A 328 ( 4.2A)
ADE  A 328 ( 3.0A)
 1.01A 1bzmA-3paoA:
undetectable		 1bzmA-3paoA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		4 PHE A  99
HIS A  22
HIS A 215
HIS A  24
 None
ZN  A 333 ( 3.3A)
ZN  A 334 ( 3.4A)
ZN  A 333 ( 3.3A)
 0.98A 1bzmA-3pnzA:
undetectable		 1bzmA-3pnzA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		6 HIS A 123
HIS A 125
HIS A 142
LEU A 214
THR A 215
TRP A 225
 ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 3.2A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-4.9A)
 0.32A 1bzmA-3q31A:
23.4		 1bzmA-3q31A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 4 HIS A 130
HIS A 178
HIS A 129
HIS A 326
 CUK  A 702 (-3.2A)
CUK  A 702 (-3.1A)
CUK  A 702 (-3.5A)
CUK  A 702 (-3.1A)
 0.99A 1bzmA-3sbqA:
undetectable		 1bzmA-3sbqA:
16.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A  96
HIS A 119
THR A 198
TRP A 208
 ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
ZN  A 261 ( 4.4A)
None
 0.30A 1bzmA-3uyqA:
41.0		 1bzmA-3uyqA:
54.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		4 HIS A 744
HIS A 730
THR A 664
HIS A 665
 ZN  A1870 ( 3.3A)
ZN  A1870 ( 3.2A)
None
ZN  A1870 ( 3.2A)
 0.96A 1bzmA-3zdrA:
undetectable		 1bzmA-3zdrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 HIS A 117
HIS A  93
LEU A 211
THR A  49
 None
 1.00A 1bzmA-3zg6A:
undetectable		 1bzmA-3zg6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A  42
HIS A 210
HIS A  69
LEU A 344
HIS A 183
 CUO  A9001 (-3.4A)
CUO  A9001 (-3.3A)
CUO  A9001 (-3.1A)
None
CUO  A9001 (-3.4A)
 1.36A 1bzmA-4bedA:
undetectable		 1bzmA-4bedA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 183
HIS A 179
HIS A 209
HIS A  69
 CUO  A9001 (-3.4A)
CUO  A9001 (-3.4A)
None
CUO  A9001 (-3.1A)
 0.99A 1bzmA-4bedA:
undetectable		 1bzmA-4bedA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 210
HIS A 179
HIS A  69
HIS A 183
 CUO  A9001 (-3.3A)
CUO  A9001 (-3.4A)
CUO  A9001 (-3.1A)
CUO  A9001 (-3.4A)
 1.00A 1bzmA-4bedA:
undetectable		 1bzmA-4bedA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A 491
HIS A 633
HIS A 602
LEU A 620
HIS A 462
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.3A)
CUO  A9002 (-3.4A)
None
CUO  A9002 (-3.2A)
 1.09A 1bzmA-4bedA:
undetectable		 1bzmA-4bedA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 633
HIS A 602
HIS A 491
HIS A 606
 CUO  A9002 (-3.3A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.3A)
 0.86A 1bzmA-4bedA:
undetectable		 1bzmA-4bedA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1046
HIS A1015
HIS A 905
HIS A1019
 CUO  A9003 (-3.2A)
CUO  A9003 (-3.1A)
CUO  A9003 (-3.5A)
CUO  A9003 (-3.4A)
 0.96A 1bzmA-4bedA:
undetectable		 1bzmA-4bedA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B1878
HIS B1847
HIS B1734
HIS B1851
 CUO  B9005 (-3.3A)
CUO  B9005 (-3.2A)
CUO  B9005 (-3.4A)
CUO  B9005 (-3.2A)
 0.97A 1bzmA-4bedB:
undetectable		 1bzmA-4bedB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2264
HIS B2260
HIS B2290
HIS B2150
 CUO  B9006 (-3.2A)
CUO  B9006 (-3.2A)
None
CUO  B9006 (-3.3A)
 0.98A 1bzmA-4bedB:
undetectable		 1bzmA-4bedB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2570
HIS B2701
HIS B2670
LEU B2688
 CUO  B9007 (-3.3A)
CUO  B9007 (-3.1A)
CUO  B9007 (-3.4A)
None
 1.00A 1bzmA-4bedB:
undetectable		 1bzmA-4bedB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2701
HIS B2670
HIS B2570
HIS B2674
 CUO  B9007 (-3.1A)
CUO  B9007 (-3.4A)
CUO  B9007 (-3.3A)
CUO  B9007 (-3.4A)
 0.96A 1bzmA-4bedB:
undetectable		 1bzmA-4bedB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B3106
HIS B3075
HIS B2974
HIS B3079
 CUO  B9008 (-3.3A)
CUO  B9008 (-2.8A)
CUO  B9008 (-2.9A)
CUO  B9008 (-3.5A)
 0.93A 1bzmA-4bedB:
undetectable		 1bzmA-4bedB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE

(Mycobacterium
avium) 		PF04909
(Amidohydro_2) 		4 HIS A  14
HIS A 358
LEU A 230
HIS A 229
 CD  A 502 (-3.4A)
CD  A 501 (-3.4A)
None
CD  A 502 (-3.6A)
 0.98A 1bzmA-4dziA:
undetectable		 1bzmA-4dziA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
HIS A  91
HIS A 108
LEU A 173
THR A 174
TRP A 184
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
 0.24A 1bzmA-4g7aA:
28.5		 1bzmA-4g7aA:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		5 HIS A   6
HIS A 174
HIS A   8
LEU A 296
HIS A 224
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
None
None
 1.45A 1bzmA-4igmA:
undetectable		 1bzmA-4igmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 HIS A 120
HIS A  48
HIS A 234
TRP A 148
 None
 0.57A 1bzmA-4jqsA:
undetectable		 1bzmA-4jqsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 HIS A 127
HIS A 126
HIS A 171
TRP A 224
 None
GOL  A 622 (-3.3A)
GOL  A 622 (-4.2A)
GOL  A 622 (-4.5A)
 0.85A 1bzmA-4pspA:
undetectable		 1bzmA-4pspA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
 0.18A 1bzmA-4qk3A:
38.5		 1bzmA-4qk3A:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 PHE A 131
HIS A  96
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
 1.08A 1bzmA-4qk3A:
38.5		 1bzmA-4qk3A:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 HIS A  58
HIS A  56
HIS A 117
HIS A 241
 FE2  A 502 ( 3.5A)
FE2  A 502 (-3.4A)
None
FE2  A 502 ( 3.7A)
 0.78A 1bzmA-4r85A:
undetectable		 1bzmA-4r85A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG

(Homo sapiens) 		PF00515
(TPR_1)
PF12895
(ANAPC3)
PF13181
(TPR_8) 		4 PHE A 516
LEU A 612
THR A 611
HIS A 615
 None
 0.93A 1bzmA-4rg6A:
undetectable		 1bzmA-4rg6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uht TRANSCRIPTIONAL
REGULATORY PROTEIN
CPXR

(Escherichia
coli) 		PF00486
(Trans_reg_C) 		4 PHE A 218
HIS A 200
LEU A 157
THR A 158
 None
 0.78A 1bzmA-4uhtA:
undetectable		 1bzmA-4uhtA:
16.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 HIS A 112
HIS A 114
HIS A 131
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.32A 1bzmA-4uovA:
30.5		 1bzmA-4uovA:
36.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		4 HIS B 942
HIS B 937
HIS B 744
THR B 732
 ZN  B1101 (-3.2A)
ZN  B1101 (-3.2A)
None
None
 0.83A 1bzmA-4wwxB:
undetectable		 1bzmA-4wwxB:
16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
HIS A  91
HIS A 108
LEU A 173
THR A 174
TRP A 184
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
None
 0.25A 1bzmA-4x5sA:
28.5		 1bzmA-4x5sA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		6 HIS A 110
HIS A 112
HIS A 129
LEU A 190
THR A 191
TRP A 201
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 ( 3.1A)
None
ZN  A 301 (-4.3A)
None
 0.44A 1bzmA-4xfwA:
25.6		 1bzmA-4xfwA:
29.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 160
HIS A 162
HIS A 179
LEU A 253
THR A 254
TRP A 264
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
None
 0.27A 1bzmA-4xixA:
25.6		 1bzmA-4xixA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 HIS A 165
HIS A 167
HIS A 184
LEU A 251
THR A 252
TRP A 262
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.1A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
None
 0.28A 1bzmA-4xz5A:
29.4		 1bzmA-4xz5A:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		5 HIS A 167
HIS A 184
LEU A 251
THR A 252
TRP A 262
 ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.1A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
None
 1.50A 1bzmA-4xz5A:
29.4		 1bzmA-4xz5A:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zon VERRUCULOGEN
SYNTHASE

(Aspergillus
fumigatus) 		PF05721
(PhyH) 		4 PHE A 159
HIS A 129
HIS A 205
LEU A 222
 None
FE2  A 402 ( 3.6A)
FE2  A 402 (-3.6A)
None
 0.93A 1bzmA-4zonA:
undetectable		 1bzmA-4zonA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
None
 0.18A 1bzmA-5cjfA:
35.1		 1bzmA-5cjfA:
34.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e57 TRANSCRIPTION
REGULATOR AMTR

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N) 		4 LEU A  33
THR A  36
HIS A  37
TRP A 114
 None
 0.83A 1bzmA-5e57A:
undetectable		 1bzmA-5e57A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 PHE A 187
HIS A 151
LEU A 256
THR A 257
TRP A 267
 None
 0.68A 1bzmA-5e5uA:
32.8		 1bzmA-5e5uA:
29.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 HIS X  93
HIS X  95
HIS X 118
LEU X 196
THR X 197
TRP X 207
 ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
ZN  X 301 (-3.1A)
None
ZN  X 301 ( 4.4A)
None
 0.26A 1bzmA-5eztX:
40.9		 1bzmA-5eztX:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		4 PHE X 129
HIS X  95
THR X 197
TRP X 207
 None
ZN  X 301 (-3.2A)
ZN  X 301 ( 4.4A)
None
 0.80A 1bzmA-5eztX:
40.9		 1bzmA-5eztX:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl4 RING-HYDROXYLATING
DIOXYGENASE

(Sinorhizobium
meliloti) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 316
HIS A 204
LEU A 212
HIS A 209
 None
FE  A 502 (-4.0A)
None
FE  A 502 (-3.7A)
 0.96A 1bzmA-5hl4A:
undetectable		 1bzmA-5hl4A:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		6 HIS A  96
HIS A  98
HIS A 115
LEU A 181
THR A 182
TRP A 192
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
 0.38A 1bzmA-5hpjA:
27.9		 1bzmA-5hpjA:
31.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		4 PHE A 197
HIS A 204
HIS A 208
HIS A  69
 None
ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
ZN  A 302 ( 4.9A)
 0.97A 1bzmA-5i3aA:
undetectable		 1bzmA-5i3aA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		4 PHE A 197
HIS A 204
HIS A 231
HIS A 208
 None
ZN  A 302 ( 3.4A)
ZN  A 302 (-3.1A)
HQE  A 303 ( 3.0A)
 0.92A 1bzmA-5i3aA:
undetectable		 1bzmA-5i3aA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		4 PHE A 473
HIS A 476
HIS A 167
HIS A 284
 None
FE  A 501 ( 3.1A)
FE  A 501 (-3.3A)
FE  A 501 ( 3.3A)
 0.97A 1bzmA-5j55A:
undetectable		 1bzmA-5j55A:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
None
 0.28A 1bzmA-5jn9A:
31.0		 1bzmA-5jn9A:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 PHE A 362
HIS A 377
HIS A 381
HIS A 224
 None
ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
ZN  A 512 (-3.5A)
 0.98A 1bzmA-5m8tA:
undetectable		 1bzmA-5m8tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 PHE A 362
HIS A 377
HIS A 404
HIS A 381
 None
ZN  A 511 ( 3.2A)
ZN  A 511 (-3.1A)
ZN  A 511 ( 3.3A)
 0.91A 1bzmA-5m8tA:
undetectable		 1bzmA-5m8tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 4 HIS A 942
HIS A 937
HIS A 744
THR A 732
 ZN  A1101 (-3.3A)
ZN  A1101 (-3.4A)
None
None
 0.83A 1bzmA-6cg0A:
undetectable		 1bzmA-6cg0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 6 HIS A 117
HIS A 119
HIS A 136
LEU A 201
THR A 202
TRP A 212
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 301 (-4.4A)
None
 0.25A 1bzmA-6ekiA:
29.5		 1bzmA-6ekiA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
None
 0.38A 1bzmA-6fe1A:
32.2		 1bzmA-6fe1A:
15.83