SIMILAR PATTERNS OF AMINO ACIDS FOR 1BX4_A_ADNA355_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cnz | PROTEIN(3-ISOPROPYLMALATEDEHYDROGENASE) (Salmonellaenterica) |
PF00180(Iso_dh) | 5 | GLY A 352VAL A 26ILE A 299ALA A 325ILE A 326 | None | 0.95A | 1bx4A-1cnzA:4.0 | 1bx4A-1cnzA:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cr5 | SEC18P (RESIDUES 22- 210) (Saccharomycescerevisiae) |
PF02359(CDC48_N)PF02933(CDC48_2) | 5 | GLY A 196GLN A 156ILE A 171GLY A 115ILE A 117 | None | 0.91A | 1bx4A-1cr5A:undetectable | 1bx4A-1cr5A:19.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dgm | ADENOSINE KINASE (Toxoplasmagondii) |
PF00294(PfkB) | 7 | THR A 278GLY A 280VAL A 302ALA A 316GLY A 317ALA A 345ILE A 349 | NoneNoneNoneACY A 370 (-4.0A)ACY A 370 (-3.5A)NoneNone | 0.62A | 1bx4A-1dgmA:42.6 | 1bx4A-1dgmA:32.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dgm | ADENOSINE KINASE (Toxoplasmagondii) |
PF00294(PfkB) | 5 | THR A 278ILE A 310GLY A 315ALA A 345ILE A 349 | NoneNoneACY A 370 (-3.1A)NoneNone | 0.95A | 1bx4A-1dgmA:42.6 | 1bx4A-1dgmA:32.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dgm | ADENOSINE KINASE (Toxoplasmagondii) |
PF00294(PfkB) | 7 | THR A 278VAL A 302ILE A 310ALA A 316GLY A 317ALA A 345ILE A 349 | NoneNoneNoneACY A 370 (-4.0A)ACY A 370 (-3.5A)NoneNone | 0.82A | 1bx4A-1dgmA:42.6 | 1bx4A-1dgmA:32.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dih | DIHYDRODIPICOLINATEREDUCTASE (Escherichiacoli) |
PF01113(DapB_N)PF05173(DapB_C) | 5 | VAL A 31ILE A 10ALA A 247GLY A 246ILE A 77 | None | 0.93A | 1bx4A-1dihA:5.7 | 1bx4A-1dihA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kve | SMK TOXIN (Millerozymafarinosa) |
no annotation | 5 | GLY B 187ILE A 54ALA B 148GLY B 209ILE A 34 | None | 0.88A | 1bx4A-1kveB:undetectable | 1bx4A-1kveB:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofu | CELL DIVISIONPROTEIN FTSZ (Pseudomonasaeruginosa) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | GLY A 18ILE A 89ALA A 113GLY A 110ALA A 114ILE A 117 | NoneNoneNoneGDP A1318 (-3.5A)NoneNone | 1.47A | 1bx4A-1ofuA:8.3 | 1bx4A-1ofuA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p74 | SHIKIMATE5-DEHYDROGENASE (Haemophilusinfluenzae) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | GLY A 133ALA A 127GLY A 128ALA A 187ILE A 124 | None | 0.86A | 1bx4A-1p74A:undetectable | 1bx4A-1p74A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p74 | SHIKIMATE5-DEHYDROGENASE (Haemophilusinfluenzae) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | ILE A 145ALA A 127GLY A 128ALA A 187ILE A 124 | None | 0.76A | 1bx4A-1p74A:undetectable | 1bx4A-1p74A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl8 | HUMAN SORBITOLDEHYDROGENASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 223ALA A 258GLY A 259ALA A 232ILE A 231 | NAD A 400 ( 4.0A)NoneNoneNoneNone | 0.89A | 1bx4A-1pl8A:4.9 | 1bx4A-1pl8A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgu | PROTEIN (NITROGENASEMOLYBDENUM IRONPROTEIN) (Klebsiellapneumoniae) |
PF00148(Oxidored_nitro) | 5 | GLY A 420ALA A 375GLY A 376ALA A 374ILE A 372 | None | 0.90A | 1bx4A-1qguA:2.7 | 1bx4A-1qguA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rk2 | RIBOKINASE (Escherichiacoli) |
PF00294(PfkB) | 6 | THR A 223GLY A 225ALA A 253GLY A 254HIS A 279ALA A 282 | ADP A 310 (-3.4A)ADP A 310 (-3.7A)ADP A 310 (-3.5A)ADP A 310 (-3.3A)ADP A 310 (-3.6A)ADP A 310 (-3.3A) | 0.44A | 1bx4A-1rk2A:32.4 | 1bx4A-1rk2A:28.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rmg | RHAMNOGALACTURONASEA (Aspergillusaculeatus) |
PF00295(Glyco_hydro_28) | 6 | THR A 64VAL A 66ILE A 55ALA A 28ALA A 39ILE A 23 | None | 0.95A | 1bx4A-1rmgA:undetectable | 1bx4A-1rmgA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u8v | GAMMA-AMINOBUTYRATEMETABOLISMDEHYDRATASE/ISOMERASE (Clostridiumaminobutyricum) |
PF03241(HpaB)PF11794(HpaB_N) | 6 | GLY A 304THR A 334ILE A 443ALA A 310GLY A 309ALA A 311 | None | 1.13A | 1bx4A-1u8vA:undetectable | 1bx4A-1u8vA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9l | GLUTAMATEDEHYDROGENASE (Pyrobaculumislandicum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | THR A 189VAL A 193GLY A 219ALA A 298ILE A 215 | NAD A 430 (-3.4A)NoneNAD A 430 (-3.4A)NoneNone | 0.92A | 1bx4A-1v9lA:undetectable | 1bx4A-1v9lA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkf | GLYCEROL UPTAKEOPERONANTITERMINATOR-RELATED PROTEIN (Thermotogamaritima) |
PF04309(G3P_antiterm) | 6 | ARG A 153ILE A 5ALA A 142GLY A 125HIS A 158ILE A 162 | None | 1.39A | 1bx4A-1vkfA:undetectable | 1bx4A-1vkfA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | GLY A 257ALA A 262GLY A 263ALA A 270ILE A 248 | None | 0.93A | 1bx4A-2bb0A:2.2 | 1bx4A-2bb0A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c49 | SUGAR KINASE MJ0406 (Methanocaldococcusjannaschii) |
PF00294(PfkB) | 5 | THR A 214GLY A 216ALA A 245GLY A 246ALA A 274 | ANP A1304 (-3.4A)ANP A1304 (-3.4A)ANP A1304 (-3.5A)ANP A1304 (-3.2A)ANP A1304 (-3.1A) | 0.50A | 1bx4A-2c49A:28.8 | 1bx4A-2c49A:27.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1q | LUCIFERIN4-MONOOXYGENASE (Luciolacruciata) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | GLY A 317THR A 529VAL A 243ALA A 350GLY A 343 | AMP A1001 ( 4.3A)AMP A1001 ( 4.7A)NoneNoneNone | 0.91A | 1bx4A-2d1qA:undetectable | 1bx4A-2d1qA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ddw | PYRIDOXINE KINASE (Escherichiacoli) |
PF08543(Phos_pyr_kin) | 5 | GLY A 232VAL A 260ALA A 35ALA A 38ILE A 34 | None | 0.95A | 1bx4A-2ddwA:18.2 | 1bx4A-2ddwA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3j | EPOXIDE HYDROLASEEPHB (Mycobacteriumtuberculosis) |
PF00561(Abhydrolase_1) | 5 | GLY A 138VAL A 129GLN A 165ILE A 275GLY A 133 | NoneNoneNoneACT A2004 ( 4.2A)None | 0.81A | 1bx4A-2e3jA:undetectable | 1bx4A-2e3jA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmh | ELECTRON TRANSFERFLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE (Sus scrofa) |
PF05187(ETF_QO)PF13450(NAD_binding_8) | 5 | GLY A 164ALA A 43GLY A 42HIS A 79ILE A 76 | NoneNoneFAD A 611 (-3.3A)FAD A 611 (-4.4A)None | 0.94A | 1bx4A-2gmhA:4.5 | 1bx4A-2gmhA:18.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6b | ADENOSINE KINASE (Homo sapiens) |
PF00294(PfkB) | 8 | GLY A 267THR A 271VAL A 284ILE A 293ALA A 298GLY A 299HIS A 324ALA A 327 | None | 0.74A | 1bx4A-2i6bA:48.1 | 1bx4A-2i6bA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6b | ADENOSINE KINASE (Homo sapiens) |
PF00294(PfkB) | 8 | THR A 265THR A 271VAL A 284ILE A 293ALA A 298GLY A 299HIS A 324ALA A 327 | None | 0.62A | 1bx4A-2i6bA:48.1 | 1bx4A-2i6bA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwz | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE (Homo sapiens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 217ALA A 233GLY A 234HIS A 203ALA A 149 | None | 0.90A | 1bx4A-2iwzA:undetectable | 1bx4A-2iwzA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4o | HYPOTHETICAL PROTEIN (Nostocpunctiforme) |
no annotation | 5 | THR A 228GLY A 226VAL A 273ALA A 247ILE A 246 | None | 0.93A | 1bx4A-2p4oA:undetectable | 1bx4A-2p4oA:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2poz | PUTATIVE DEHYDRATASE (Mesorhizobiumjaponicum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 45ILE A 10ALA A 37GLY A 38ALA A 91 | None | 0.86A | 1bx4A-2pozA:undetectable | 1bx4A-2pozA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6r | CELL DIVISIONPROTEIN FTSZ (Aquifexaeolicus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | GLY 1 14ILE 1 85ALA 1 109GLY 1 106ALA 1 110ILE 1 113 | NoneNoneNoneGDP 1 339 (-3.5A)NoneNone | 1.44A | 1bx4A-2r6r1:6.2 | 1bx4A-2r6r1:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9v | ATP SYNTHASE SUBUNITALPHA (Thermotogamaritima) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 6 | GLY A 113ILE A 96ALA A 242GLY A 243ALA A 245ILE A 130 | None | 1.36A | 1bx4A-2r9vA:2.1 | 1bx4A-2r9vA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rbc | SUGAR KINASE (Agrobacteriumfabrum) |
PF00294(PfkB) | 6 | THR A 220GLY A 222GLN A 243ALA A 252GLY A 253ALA A 281 | EDO A 331 (-3.9A)EDO A 331 (-3.1A)NoneNoneNoneEDO A 331 ( 3.7A) | 1.29A | 1bx4A-2rbcA:29.5 | 1bx4A-2rbcA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vxy | CELL DIVISIONPROTEIN FTSZ (Bacillussubtilis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | GLY A 18ILE A 89ALA A 113GLY A 110ALA A 114ILE A 117 | NoneNoneNoneCIT A 401 (-4.0A)NoneNone | 1.46A | 1bx4A-2vxyA:8.2 | 1bx4A-2vxyA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bf5 | RIBOKINASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF00294(PfkB) | 6 | THR A 196GLY A 198ALA A 225GLY A 226ALA A 254ILE A 258 | PGO A 290 (-4.0A)PGO A 290 (-3.8A)PGO A 290 ( 4.1A)PGO A 290 ( 4.6A)PGO A 290 ( 3.8A)None | 0.76A | 1bx4A-3bf5A:21.1 | 1bx4A-3bf5A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwc | PUTATIVE GLYCERATEKINASE 2 (Salmonellaenterica) |
PF02595(Gly_kinase) | 6 | ILE A 131ALA A 86GLY A 78HIS A 120ALA A 121ILE A 129 | None | 1.43A | 1bx4A-3cwcA:2.9 | 1bx4A-3cwcA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da1 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Bacillushalodurans) |
PF01266(DAO)PF16901(DAO_C) | 5 | GLY A 32THR A 173ALA A 227GLY A 25ILE A 369 | NoneNoneNoneFAD A 609 ( 4.0A)None | 0.88A | 1bx4A-3da1A:3.4 | 1bx4A-3da1A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewm | UNCHARACTERIZEDSUGAR KINASE PH1459 (Pyrococcushorikoshii) |
PF00294(PfkB) | 5 | THR A 215GLY A 217ALA A 245GLY A 246ALA A 276 | None | 0.43A | 1bx4A-3ewmA:29.1 | 1bx4A-3ewmA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fn4 | NAD-DEPENDENTFORMATEDEHYDROGENASE (Moraxella sp.) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | THR A 252GLY A 195ALA A 199GLY A 203ALA A 198 | None | 0.85A | 1bx4A-3fn4A:4.7 | 1bx4A-3fn4A:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1w | SUGAR ABCTRANSPORTER (Bacillushalodurans) |
PF13407(Peripla_BP_4) | 6 | GLY A 207ARG A 206GLY A 237HIS A 179ALA A 231ILE A 171 | None | 1.30A | 1bx4A-3g1wA:4.7 | 1bx4A-3g1wA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hea | ARYLESTERASE (Pseudomonasfluorescens) |
PF00561(Abhydrolase_1) | 5 | ILE A 210ALA A 234GLY A 231ALA A 235ILE A 238 | None | 0.89A | 1bx4A-3heaA:undetectable | 1bx4A-3heaA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hee | RIBOSE-5-PHOSPHATEISOMERASE (Ruminiclostridiumthermocellum) |
PF02502(LacAB_rpiB) | 5 | GLY A 61ARG A 60GLY A 46ALA A 75ILE A 81 | None | 0.95A | 1bx4A-3heeA:undetectable | 1bx4A-3heeA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hs3 | RIBOSE OPERONREPRESSOR (Lactobacillusacidophilus) |
PF13377(Peripla_BP_3) | 5 | GLY A 80VAL A 84ILE A 64HIS A 291ILE A 121 | None | 0.88A | 1bx4A-3hs3A:3.7 | 1bx4A-3hs3A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3y | CARBOHYDRATE KINASE (Klebsiellapneumoniae) |
PF00294(PfkB) | 5 | THR A 200GLY A 202ALA A 230GLY A 231ALA A 261 | None | 0.69A | 1bx4A-3i3yA:25.8 | 1bx4A-3i3yA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4j | AMINOTRANSFERASE,CLASS III (Deinococcusradiodurans) |
PF00202(Aminotran_3) | 6 | GLY A 46ILE A 312ALA A 265GLY A 266ALA A 41ILE A 43 | None | 1.16A | 1bx4A-3i4jA:undetectable | 1bx4A-3i4jA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k92 | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Bacillussubtilis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | THR A 200VAL A 204GLY A 230ALA A 302ILE A 226 | None | 0.92A | 1bx4A-3k92A:undetectable | 1bx4A-3k92A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9d | ALDEHYDEDEHYDROGENASE (Listeriamonocytogenes) |
PF00171(Aldedh) | 6 | THR A 412GLY A 409ALA A 404GLY A 403ALA A 252ILE A 250 | None | 1.31A | 1bx4A-3k9dA:undetectable | 1bx4A-3k9dA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd6 | CARBOHYDRATE KINASE,PFKB FAMILY (Chlorobaculumtepidum) |
PF00294(PfkB) | 5 | GLY A 206ILE A 229ALA A 235GLY A 236ALA A 269 | NoneNoneNoneGOL A 501 ( 3.2A)None | 0.74A | 1bx4A-3kd6A:28.3 | 1bx4A-3kd6A:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ld2 | PUTATIVEACETYLTRANSFERASE (Streptococcusmutans) |
PF00583(Acetyltransf_1) | 5 | GLY A 93ILE A 99ALA A 52GLY A 60ILE A 3 | COA A 164 (-3.3A)NoneNoneNoneNone | 0.92A | 1bx4A-3ld2A:undetectable | 1bx4A-3ld2A:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhx | KETODEOXYGLUCONOKINASE (Shigellaflexneri) |
PF00294(PfkB) | 6 | GLY A 303ALA A 335GLY A 336HIS A 361ALA A 364ILE A 368 | None | 0.64A | 1bx4A-3lhxA:31.2 | 1bx4A-3lhxA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm6 | STAGE V SPORULATIONPROTEIN AD (Bacillussubtilis) |
PF07451(SpoVAD) | 6 | GLY A 202THR A 162ILE A 195ALA A 309GLY A 308ILE A 322 | None | 1.30A | 1bx4A-3lm6A:undetectable | 1bx4A-3lm6A:22.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3loo | ANOPHELES GAMBIAEADENOSINE KINASE (Anophelesgambiae) |
PF00294(PfkB) | 7 | THR A 263GLY A 265VAL A 284ALA A 298GLY A 299ALA A 327ILE A 331 | B4P A 349 (-3.5A)B4P A 349 (-3.6A)NoneB4P A 349 (-3.3A)B4P A 349 (-3.3A)B4P A 349 (-3.4A)None | 0.56A | 1bx4A-3looA:51.0 | 1bx4A-3looA:48.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1a | PUTATIVEDEHYDROGENASE (Streptomycesavermitilis) |
PF00106(adh_short) | 5 | GLY A 18VAL A 10ILE A 232ALA A 24ALA A 25 | None | 0.83A | 1bx4A-3m1aA:6.2 | 1bx4A-3m1aA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0r | RESPONSE REGULATOR (Caulobactervibrioides) |
PF00072(Response_reg) | 6 | THR A 141VAL A 143ILE A 238GLY A 252ALA A 254ILE A 217 | None | 1.42A | 1bx4A-3n0rA:undetectable | 1bx4A-3n0rA:21.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3otx | ADENOSINE KINASE,PUTATIVE (Trypanosomabrucei) |
PF00294(PfkB) | 9 | THR A 264THR A 270VAL A 283GLN A 288ALA A 297GLY A 298HIS A 323ALA A 326ILE A 330 | AP5 A 346 (-3.6A)AP5 A 346 (-4.5A)AP5 A 346 (-4.1A)AP5 A 346 (-3.1A)AP5 A 346 (-3.4A)AP5 A 346 (-3.2A)AP5 A 346 (-3.8A)AP5 A 346 (-3.0A)AP5 A 346 (-4.9A) | 0.58A | 1bx4A-3otxA:49.7 | 1bx4A-3otxA:40.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pen | TRANSLATIONINITIATION FACTOR 2SUBUNIT GAMMA (Sulfolobussolfataricus) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF09173(eIF2_C) | 6 | THR A 365ILE A 138ALA A 108GLY A 107ALA A 109ILE A 139 | None | 1.42A | 1bx4A-3penA:undetectable | 1bx4A-3penA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ph3 | RIBOSE-5-PHOSPHATEISOMERASE (Ruminiclostridiumthermocellum) |
PF02502(LacAB_rpiB) | 5 | GLY A 61ARG A 60GLY A 46ALA A 75ILE A 81 | None | 0.94A | 1bx4A-3ph3A:undetectable | 1bx4A-3ph3A:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qz6 | HPCH/HPAI ALDOLASE (Desulfitobacteriumhafniense) |
PF03328(HpcH_HpaI) | 6 | THR A 99THR A 103VAL A 165ILE A 156GLY A 93ILE A 147 | None | 1.36A | 1bx4A-3qz6A:undetectable | 1bx4A-3qz6A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ry7 | RIBOKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | THR A 222GLY A 224THR A 228ALA A 252GLY A 253 | None | 0.49A | 1bx4A-3ry7A:28.3 | 1bx4A-3ry7A:26.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 5 | THR A 245ALA A 276GLY A 277ALA A 305ILE A 309 | ADP A 354 (-3.3A)ADP A 354 (-3.4A)ADP A 354 (-3.4A)ADP A 354 (-2.7A)None | 0.69A | 1bx4A-3uboA:39.3 | 1bx4A-3uboA:27.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uho | GLUTAMATE RACEMASE (Campylobacterjejuni) |
PF01177(Asp_Glu_race) | 6 | ILE A 67ALA A 95GLY A 96HIS A 202ALA A 206ILE A 207 | NoneNoneNoneNoneEDO A 264 (-3.3A)None | 1.23A | 1bx4A-3uhoA:2.8 | 1bx4A-3uhoA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uzb | BRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Deinococcusradiodurans) |
PF01063(Aminotran_4) | 5 | THR A 309GLY A 300ILE A 236ALA A 239ILE A 226 | None | 0.88A | 1bx4A-3uzbA:undetectable | 1bx4A-3uzbA:21.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 8 | THR A 265GLY A 267VAL A 286ILE A 294ALA A 300GLY A 301ALA A 329ILE A 333 | None | 0.62A | 1bx4A-3vasA:49.7 | 1bx4A-3vasA:36.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 5 | THR A 265ILE A 294GLY A 299ALA A 329ILE A 333 | NoneNoneADN A 401 ( 3.8A)NoneNone | 0.94A | 1bx4A-3vasA:49.7 | 1bx4A-3vasA:36.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwz | D-LACTATEDEHYDROGENASE(FERMENTATIVE) (Pseudomonasaeruginosa) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | GLY A 256THR A 293ILE A 200HIS A 108ILE A 113 | None | 0.85A | 1bx4A-3wwzA:3.0 | 1bx4A-3wwzA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ain | GLYCINE BETAINETRANSPORTER BETP (Corynebacteriumglutamicum) |
PF02028(BCCT) | 5 | GLY A 382VAL A 475ILE A 388ALA A 148GLY A 149 | None | 0.91A | 1bx4A-4ainA:undetectable | 1bx4A-4ainA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e16 | PRECORRIN-4C(11)-METHYLTRANSFERASE (Clostridioidesdifficile) |
PF00590(TP_methylase) | 5 | THR A 186VAL A 226GLY A 180ALA A 155ILE A 151 | None | 0.95A | 1bx4A-4e16A:undetectable | 1bx4A-4e16A:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e69 | 2-DEHYDRO-3-DEOXYGLUCONOKINASE (Oceanicolagranulosus) |
PF00294(PfkB) | 5 | GLY A 225VAL A 242ALA A 254GLY A 255ALA A 283 | None | 0.35A | 1bx4A-4e69A:30.5 | 1bx4A-4e69A:25.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fr2 | 1,3-PROPANEDIOLDEHYDROGENASE (Oenococcus oeni) |
PF00465(Fe-ADH) | 5 | GLY A 145ILE A 227ALA A 254GLY A 255HIS A 267 | NoneNoneNoneNone NI A 501 (-3.4A) | 0.91A | 1bx4A-4fr2A:3.3 | 1bx4A-4fr2A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iil | MEMBRANE LIPOPROTEINTPN38(B) (Treponemapallidum) |
PF02608(Bmp) | 5 | VAL A 26GLN A 121ILE A 164GLY A 154ILE A 213 | RBF A 401 (-3.9A)RBF A 401 (-3.3A)RBF A 401 ( 4.7A)NoneRBF A 401 (-3.7A) | 0.89A | 1bx4A-4iilA:4.9 | 1bx4A-4iilA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jga | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Rickettsiarickettsii) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 202ILE A 366ALA A 93GLY A 90ALA A 94 | None | 0.92A | 1bx4A-4jgaA:undetectable | 1bx4A-4jgaA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3c | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMA ([Haemophilus]ducreyi) |
PF01103(Bac_surface_Ag)PF07244(POTRA) | 5 | GLY A 313ARG A 312ALA A 340GLY A 341ALA A 317 | None | 0.94A | 1bx4A-4k3cA:undetectable | 1bx4A-4k3cA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmp | ALANINEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 5 | GLY A 22ILE A 5ALA A 55GLY A 54ILE A 35 | None | 0.68A | 1bx4A-4lmpA:4.0 | 1bx4A-4lmpA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ls5 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 188THR A 165ALA A 77ALA A 142ILE A 146 | None | 0.82A | 1bx4A-4ls5A:undetectable | 1bx4A-4ls5A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m9c | BACTERIALTRANSFERASEHEXAPEPTIDE (THREEREPEATS) FAMILYPROTEIN (Acinetobacterbaumannii) |
PF00132(Hexapep) | 5 | GLY A 192ALA A 152GLY A 151ALA A 149ILE A 166 | None | 0.83A | 1bx4A-4m9cA:undetectable | 1bx4A-4m9cA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzy | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Enterococcusfaecalis) |
PF04095(NAPRTase) | 5 | GLY A 55ILE A 436ALA A 177ALA A 142ILE A 180 | NoneGOL A 504 ( 4.3A)NoneNoneNone | 0.89A | 1bx4A-4mzyA:undetectable | 1bx4A-4mzyA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pvv | ADENOSINE KINASE (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 5 | THR A 223GLY A 225VAL A 243GLY A 256ALA A 284 | None | 0.58A | 1bx4A-4pvvA:27.5 | 1bx4A-4pvvA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u39 | CELL DIVISIONPROTEIN FTSZ (Bacillussubtilis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | GLY A 18ILE A 89ALA A 113GLY A 110ALA A 114ILE A 117 | NoneNoneNonePO4 A 401 (-3.8A)NoneNone | 1.41A | 1bx4A-4u39A:6.9 | 1bx4A-4u39A:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u9p | UPF0264 PROTEINMJ1099 (Methanocaldococcusjannaschii) |
PF04476(4HFCP_synth) | 5 | GLY A 206ILE A 194ALA A 210GLY A 209ALA A 211 | None | 0.77A | 1bx4A-4u9pA:undetectable | 1bx4A-4u9pA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 5 | THR A 217GLY A 219ALA A 247GLY A 248ALA A 289 | ANP A 401 (-3.5A)ANP A 401 (-3.6A)ANP A 401 (-3.3A)ANP A 401 (-3.4A)ANP A 401 (-3.5A) | 0.45A | 1bx4A-4wjmA:29.2 | 1bx4A-4wjmA:25.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8f | RIBOKINASE (Vibrio cholerae) |
PF00294(PfkB) | 6 | THR A 220GLY A 222ALA A 250GLY A 251HIS A 276ALA A 279 | None | 0.61A | 1bx4A-4x8fA:30.0 | 1bx4A-4x8fA:26.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yji | ARYL ACYLAMIDASE (bacteriumCSBL00001) |
PF01425(Amidase) | 6 | THR A 142GLY A 162ILE A 188ALA A 167GLY A 166ALA A 168 | None | 1.25A | 1bx4A-4yjiA:undetectable | 1bx4A-4yjiA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgs | PUTATIVE D-LACTATEDEHYDROGENASE (Chlamydomonasreinhardtii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | GLY A 290THR A 333ILE A 234HIS A 142ILE A 147 | None | 0.91A | 1bx4A-4zgsA:3.1 | 1bx4A-4zgsA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a31 | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 1 (Homo sapiens) |
PF12859(ANAPC1) | 5 | GLY A1258ILE A1232ALA A1298GLY A1299ALA A1297 | None | 0.94A | 1bx4A-5a31A:undetectable | 1bx4A-5a31A:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5but | KTR SYSTEM POTASSIUMUPTAKE PROTEIN A,KTRSYSTEM POTASSIUMUPTAKE PROTEIN A (Bacillussubtilis) |
PF02254(TrkA_N) | 5 | GLY A 18VAL A 11ILE A 122ALA A 275ILE A 274 | None | 0.94A | 1bx4A-5butA:8.2 | 1bx4A-5butA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5but | KTR SYSTEM POTASSIUMUPTAKE PROTEIN A,KTRSYSTEM POTASSIUMUPTAKE PROTEIN A (Bacillussubtilis) |
PF02254(TrkA_N) | 5 | GLY A 160VAL A 153ILE A 264ALA A 133ILE A 132 | None | 0.93A | 1bx4A-5butA:8.2 | 1bx4A-5butA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c41 | RIBOKINASE (Homo sapiens) |
PF00294(PfkB) | 5 | THR A 235GLY A 237ALA A 267GLY A 268ALA A 298 | ACP A 401 (-3.2A)ACP A 401 (-3.3A)ACP A 401 (-3.5A)ACP A 401 (-3.4A)ACP A 401 (-3.3A) | 0.49A | 1bx4A-5c41A:32.3 | 1bx4A-5c41A:26.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dx5 | METHIONINEGAMMA-LYASE (Clostridiumsporogenes) |
PF01053(Cys_Met_Meta_PP) | 6 | THR A 244GLY A 239ILE A 232ALA A 91GLY A 90ALA A 85 | None | 1.17A | 1bx4A-5dx5A:3.8 | 1bx4A-5dx5A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxf | ACRYLYL-COAREDUCTASE ACUI (Ruegeriapomeroyi) |
PF00107(ADH_zinc_N) | 5 | GLY A 182ILE A 198ALA A 158GLY A 157ALA A 159 | NoneNoneNone BR A 401 (-3.6A)None | 0.95A | 1bx4A-5gxfA:4.2 | 1bx4A-5gxfA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h6j | PIERISIN-1 (Pieris rapae) |
no annotation | 6 | THR A 115ILE A 28ALA A 15GLY A 171ALA A 14ILE A 12 | None | 1.27A | 1bx4A-5h6jA:undetectable | 1bx4A-5h6jA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1u | NAD(P)H:FLAVINOXIDOREDUCTASE SYE4 (Shewanellaoneidensis) |
PF00724(Oxidored_FMN) | 5 | GLY A 178VAL A 171ILE A 181GLY A 227ILE A 222 | None | 0.92A | 1bx4A-5k1uA:undetectable | 1bx4A-5k1uA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5j | THIOREDOXINREDUCTASE (Giardiaintestinalis) |
PF07992(Pyr_redox_2) | 5 | THR A 32GLY A 10ALA A 21GLY A 22ALA A 303 | None | 0.82A | 1bx4A-5m5jA:undetectable | 1bx4A-5m5jA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tjf | ALLOPHYCOCYANIN BETASUBUNIT (Gracilariachilensis) |
PF00502(Phycobilisome) | 6 | THR B 33GLY B 29ARG B 28ALA B 4GLY B 99ILE B 5 | None | 1.41A | 1bx4A-5tjfB:undetectable | 1bx4A-5tjfB:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uju | NAD-DEPENDENTALDEHYDEDEHYDROGENASE (Burkholderiamultivorans) |
PF00171(Aldedh) | 6 | THR A 321THR A 358ILE A 349ALA A 328ALA A 371ILE A 372 | None | 1.23A | 1bx4A-5ujuA:undetectable | 1bx4A-5ujuA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zya | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | GLY C 880ILE C 872GLY C 845ALA C 847ILE C 850 | None | 0.92A | 1bx4A-5zyaC:undetectable | 1bx4A-5zyaC:12.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6alk | - (-) |
no annotation | 5 | ILE A 56ALA A 37GLY A 142ALA A 34ILE A 38 | None | 0.92A | 1bx4A-6alkA:undetectable | 1bx4A-6alkA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d0p | PIRIN FAMILY PROTEIN (Acinetobacterbaumannii) |
no annotation | 5 | VAL A 69ALA A 173GLY A 172ALA A 174ILE A 143 | None | 0.93A | 1bx4A-6d0pA:undetectable | 1bx4A-6d0pA:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eqn | TRYPTOPHAN SYNTHASEBETA CHAIN 2 (Sulfobacillus) |
no annotation | 6 | GLY B 140ARG B 169THR B 132ALA B 146ALA B 115ILE B 112 | None | 1.43A | 1bx4A-6eqnB:2.4 | 1bx4A-6eqnB:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eqn | TRYPTOPHAN SYNTHASEBETA CHAIN 2 (Sulfobacillus) |
no annotation | 5 | GLY B 263ALA B 268HIS B 110ALA B 269ILE B 233 | PLP B 501 (-3.5A)NonePLP B 501 (-3.9A)NoneNone | 0.95A | 1bx4A-6eqnB:2.4 | 1bx4A-6eqnB:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eqn | TRYPTOPHAN SYNTHASEBETA CHAIN 2 (Sulfobacillus) |
no annotation | 6 | THR B 132GLY B 140ARG B 169ALA B 146ALA B 115ILE B 112 | None | 1.39A | 1bx4A-6eqnB:2.4 | 1bx4A-6eqnB:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f8y | THREONYLCARBAMOYL-AMP SYNTHASE (Pyrococcusabyssi) |
no annotation | 5 | GLY A 172THR A 175ILE A 4ALA A 30ILE A 169 | None | 0.95A | 1bx4A-6f8yA:undetectable | 1bx4A-6f8yA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fn1 | HUMAN-MOUSE CHIMERICABCB1 (ABCBHM) (Homo sapiens) |
no annotation | 5 | ARG A 40VAL A 33ILE A 146ALA A 357ILE A 181 | None | 0.84A | 1bx4A-6fn1A:undetectable | 1bx4A-6fn1A:14.57 |