SIMILAR PATTERNS OF AMINO ACIDS FOR 1BX4_A_ADNA355_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)


(Salmonella
enterica)
PF00180
(Iso_dh)
5 GLY A 352
VAL A  26
ILE A 299
ALA A 325
ILE A 326
None
0.95A 1bx4A-1cnzA:
4.0
1bx4A-1cnzA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cr5 SEC18P (RESIDUES 22
- 210)


(Saccharomyces
cerevisiae)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
5 GLY A 196
GLN A 156
ILE A 171
GLY A 115
ILE A 117
None
0.91A 1bx4A-1cr5A:
undetectable
1bx4A-1cr5A:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii)
PF00294
(PfkB)
7 THR A 278
GLY A 280
VAL A 302
ALA A 316
GLY A 317
ALA A 345
ILE A 349
None
None
None
ACY  A 370 (-4.0A)
ACY  A 370 (-3.5A)
None
None
0.62A 1bx4A-1dgmA:
42.6
1bx4A-1dgmA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii)
PF00294
(PfkB)
5 THR A 278
ILE A 310
GLY A 315
ALA A 345
ILE A 349
None
None
ACY  A 370 (-3.1A)
None
None
0.95A 1bx4A-1dgmA:
42.6
1bx4A-1dgmA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii)
PF00294
(PfkB)
7 THR A 278
VAL A 302
ILE A 310
ALA A 316
GLY A 317
ALA A 345
ILE A 349
None
None
None
ACY  A 370 (-4.0A)
ACY  A 370 (-3.5A)
None
None
0.82A 1bx4A-1dgmA:
42.6
1bx4A-1dgmA:
32.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dih DIHYDRODIPICOLINATE
REDUCTASE


(Escherichia
coli)
PF01113
(DapB_N)
PF05173
(DapB_C)
5 VAL A  31
ILE A  10
ALA A 247
GLY A 246
ILE A  77
None
0.93A 1bx4A-1dihA:
5.7
1bx4A-1dihA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kve SMK TOXIN

(Millerozyma
farinosa)
no annotation 5 GLY B 187
ILE A  54
ALA B 148
GLY B 209
ILE A  34
None
0.88A 1bx4A-1kveB:
undetectable
1bx4A-1kveB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ


(Pseudomonas
aeruginosa)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 GLY A  18
ILE A  89
ALA A 113
GLY A 110
ALA A 114
ILE A 117
None
None
None
GDP  A1318 (-3.5A)
None
None
1.47A 1bx4A-1ofuA:
8.3
1bx4A-1ofuA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p74 SHIKIMATE
5-DEHYDROGENASE


(Haemophilus
influenzae)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 GLY A 133
ALA A 127
GLY A 128
ALA A 187
ILE A 124
None
0.86A 1bx4A-1p74A:
undetectable
1bx4A-1p74A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p74 SHIKIMATE
5-DEHYDROGENASE


(Haemophilus
influenzae)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 ILE A 145
ALA A 127
GLY A 128
ALA A 187
ILE A 124
None
0.76A 1bx4A-1p74A:
undetectable
1bx4A-1p74A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ILE A 223
ALA A 258
GLY A 259
ALA A 232
ILE A 231
NAD  A 400 ( 4.0A)
None
None
None
None
0.89A 1bx4A-1pl8A:
4.9
1bx4A-1pl8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)


(Klebsiella
pneumoniae)
PF00148
(Oxidored_nitro)
5 GLY A 420
ALA A 375
GLY A 376
ALA A 374
ILE A 372
None
0.90A 1bx4A-1qguA:
2.7
1bx4A-1qguA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli)
PF00294
(PfkB)
6 THR A 223
GLY A 225
ALA A 253
GLY A 254
HIS A 279
ALA A 282
ADP  A 310 (-3.4A)
ADP  A 310 (-3.7A)
ADP  A 310 (-3.5A)
ADP  A 310 (-3.3A)
ADP  A 310 (-3.6A)
ADP  A 310 (-3.3A)
0.44A 1bx4A-1rk2A:
32.4
1bx4A-1rk2A:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A


(Aspergillus
aculeatus)
PF00295
(Glyco_hydro_28)
6 THR A  64
VAL A  66
ILE A  55
ALA A  28
ALA A  39
ILE A  23
None
0.95A 1bx4A-1rmgA:
undetectable
1bx4A-1rmgA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E


(Clostridium
aminobutyricum)
PF03241
(HpaB)
PF11794
(HpaB_N)
6 GLY A 304
THR A 334
ILE A 443
ALA A 310
GLY A 309
ALA A 311
None
1.13A 1bx4A-1u8vA:
undetectable
1bx4A-1u8vA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE


(Pyrobaculum
islandicum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 THR A 189
VAL A 193
GLY A 219
ALA A 298
ILE A 215
NAD  A 430 (-3.4A)
None
NAD  A 430 (-3.4A)
None
None
0.92A 1bx4A-1v9lA:
undetectable
1bx4A-1v9lA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN


(Thermotoga
maritima)
PF04309
(G3P_antiterm)
6 ARG A 153
ILE A   5
ALA A 142
GLY A 125
HIS A 158
ILE A 162
None
1.39A 1bx4A-1vkfA:
undetectable
1bx4A-1vkfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E


(Bacillus
subtilis)
PF01979
(Amidohydro_1)
5 GLY A 257
ALA A 262
GLY A 263
ALA A 270
ILE A 248
None
0.93A 1bx4A-2bb0A:
2.2
1bx4A-2bb0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii)
PF00294
(PfkB)
5 THR A 214
GLY A 216
ALA A 245
GLY A 246
ALA A 274
ANP  A1304 (-3.4A)
ANP  A1304 (-3.4A)
ANP  A1304 (-3.5A)
ANP  A1304 (-3.2A)
ANP  A1304 (-3.1A)
0.50A 1bx4A-2c49A:
28.8
1bx4A-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE


(Luciola
cruciata)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 GLY A 317
THR A 529
VAL A 243
ALA A 350
GLY A 343
AMP  A1001 ( 4.3A)
AMP  A1001 ( 4.7A)
None
None
None
0.91A 1bx4A-2d1qA:
undetectable
1bx4A-2d1qA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddw PYRIDOXINE KINASE

(Escherichia
coli)
PF08543
(Phos_pyr_kin)
5 GLY A 232
VAL A 260
ALA A  35
ALA A  38
ILE A  34
None
0.95A 1bx4A-2ddwA:
18.2
1bx4A-2ddwA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB


(Mycobacterium
tuberculosis)
PF00561
(Abhydrolase_1)
5 GLY A 138
VAL A 129
GLN A 165
ILE A 275
GLY A 133
None
None
None
ACT  A2004 ( 4.2A)
None
0.81A 1bx4A-2e3jA:
undetectable
1bx4A-2e3jA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE


(Sus scrofa)
PF05187
(ETF_QO)
PF13450
(NAD_binding_8)
5 GLY A 164
ALA A  43
GLY A  42
HIS A  79
ILE A  76
None
None
FAD  A 611 (-3.3A)
FAD  A 611 (-4.4A)
None
0.94A 1bx4A-2gmhA:
4.5
1bx4A-2gmhA:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens)
PF00294
(PfkB)
8 GLY A 267
THR A 271
VAL A 284
ILE A 293
ALA A 298
GLY A 299
HIS A 324
ALA A 327
None
0.74A 1bx4A-2i6bA:
48.1
1bx4A-2i6bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens)
PF00294
(PfkB)
8 THR A 265
THR A 271
VAL A 284
ILE A 293
ALA A 298
GLY A 299
HIS A 324
ALA A 327
None
0.62A 1bx4A-2i6bA:
48.1
1bx4A-2i6bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE


(Homo sapiens)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 217
ALA A 233
GLY A 234
HIS A 203
ALA A 149
None
0.90A 1bx4A-2iwzA:
undetectable
1bx4A-2iwzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme)
no annotation 5 THR A 228
GLY A 226
VAL A 273
ALA A 247
ILE A 246
None
0.93A 1bx4A-2p4oA:
undetectable
1bx4A-2p4oA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A  45
ILE A  10
ALA A  37
GLY A  38
ALA A  91
None
0.86A 1bx4A-2pozA:
undetectable
1bx4A-2pozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ


(Aquifex
aeolicus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 GLY 1  14
ILE 1  85
ALA 1 109
GLY 1 106
ALA 1 110
ILE 1 113
None
None
None
GDP  1 339 (-3.5A)
None
None
1.44A 1bx4A-2r6r1:
6.2
1bx4A-2r6r1:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA


(Thermotoga
maritima)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
6 GLY A 113
ILE A  96
ALA A 242
GLY A 243
ALA A 245
ILE A 130
None
1.36A 1bx4A-2r9vA:
2.1
1bx4A-2r9vA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum)
PF00294
(PfkB)
6 THR A 220
GLY A 222
GLN A 243
ALA A 252
GLY A 253
ALA A 281
EDO  A 331 (-3.9A)
EDO  A 331 (-3.1A)
None
None
None
EDO  A 331 ( 3.7A)
1.29A 1bx4A-2rbcA:
29.5
1bx4A-2rbcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 GLY A  18
ILE A  89
ALA A 113
GLY A 110
ALA A 114
ILE A 117
None
None
None
CIT  A 401 (-4.0A)
None
None
1.46A 1bx4A-2vxyA:
8.2
1bx4A-2vxyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF00294
(PfkB)
6 THR A 196
GLY A 198
ALA A 225
GLY A 226
ALA A 254
ILE A 258
PGO  A 290 (-4.0A)
PGO  A 290 (-3.8A)
PGO  A 290 ( 4.1A)
PGO  A 290 ( 4.6A)
PGO  A 290 ( 3.8A)
None
0.76A 1bx4A-3bf5A:
21.1
1bx4A-3bf5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2


(Salmonella
enterica)
PF02595
(Gly_kinase)
6 ILE A 131
ALA A  86
GLY A  78
HIS A 120
ALA A 121
ILE A 129
None
1.43A 1bx4A-3cwcA:
2.9
1bx4A-3cwcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Bacillus
halodurans)
PF01266
(DAO)
PF16901
(DAO_C)
5 GLY A  32
THR A 173
ALA A 227
GLY A  25
ILE A 369
None
None
None
FAD  A 609 ( 4.0A)
None
0.88A 1bx4A-3da1A:
3.4
1bx4A-3da1A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459


(Pyrococcus
horikoshii)
PF00294
(PfkB)
5 THR A 215
GLY A 217
ALA A 245
GLY A 246
ALA A 276
None
0.43A 1bx4A-3ewmA:
29.1
1bx4A-3ewmA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE


(Moraxella sp.)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 THR A 252
GLY A 195
ALA A 199
GLY A 203
ALA A 198
None
0.85A 1bx4A-3fn4A:
4.7
1bx4A-3fn4A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1w SUGAR ABC
TRANSPORTER


(Bacillus
halodurans)
PF13407
(Peripla_BP_4)
6 GLY A 207
ARG A 206
GLY A 237
HIS A 179
ALA A 231
ILE A 171
None
1.30A 1bx4A-3g1wA:
4.7
1bx4A-3g1wA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens)
PF00561
(Abhydrolase_1)
5 ILE A 210
ALA A 234
GLY A 231
ALA A 235
ILE A 238
None
0.89A 1bx4A-3heaA:
undetectable
1bx4A-3heaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
5 GLY A  61
ARG A  60
GLY A  46
ALA A  75
ILE A  81
None
0.95A 1bx4A-3heeA:
undetectable
1bx4A-3heeA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR


(Lactobacillus
acidophilus)
PF13377
(Peripla_BP_3)
5 GLY A  80
VAL A  84
ILE A  64
HIS A 291
ILE A 121
None
0.88A 1bx4A-3hs3A:
3.7
1bx4A-3hs3A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae)
PF00294
(PfkB)
5 THR A 200
GLY A 202
ALA A 230
GLY A 231
ALA A 261
None
0.69A 1bx4A-3i3yA:
25.8
1bx4A-3i3yA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III


(Deinococcus
radiodurans)
PF00202
(Aminotran_3)
6 GLY A  46
ILE A 312
ALA A 265
GLY A 266
ALA A  41
ILE A  43
None
1.16A 1bx4A-3i4jA:
undetectable
1bx4A-3i4jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Bacillus
subtilis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 THR A 200
VAL A 204
GLY A 230
ALA A 302
ILE A 226
None
0.92A 1bx4A-3k92A:
undetectable
1bx4A-3k92A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE


(Listeria
monocytogenes)
PF00171
(Aldedh)
6 THR A 412
GLY A 409
ALA A 404
GLY A 403
ALA A 252
ILE A 250
None
1.31A 1bx4A-3k9dA:
undetectable
1bx4A-3k9dA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY


(Chlorobaculum
tepidum)
PF00294
(PfkB)
5 GLY A 206
ILE A 229
ALA A 235
GLY A 236
ALA A 269
None
None
None
GOL  A 501 ( 3.2A)
None
0.74A 1bx4A-3kd6A:
28.3
1bx4A-3kd6A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld2 PUTATIVE
ACETYLTRANSFERASE


(Streptococcus
mutans)
PF00583
(Acetyltransf_1)
5 GLY A  93
ILE A  99
ALA A  52
GLY A  60
ILE A   3
COA  A 164 (-3.3A)
None
None
None
None
0.92A 1bx4A-3ld2A:
undetectable
1bx4A-3ld2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE


(Shigella
flexneri)
PF00294
(PfkB)
6 GLY A 303
ALA A 335
GLY A 336
HIS A 361
ALA A 364
ILE A 368
None
0.64A 1bx4A-3lhxA:
31.2
1bx4A-3lhxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD


(Bacillus
subtilis)
PF07451
(SpoVAD)
6 GLY A 202
THR A 162
ILE A 195
ALA A 309
GLY A 308
ILE A 322
None
1.30A 1bx4A-3lm6A:
undetectable
1bx4A-3lm6A:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE


(Anopheles
gambiae)
PF00294
(PfkB)
7 THR A 263
GLY A 265
VAL A 284
ALA A 298
GLY A 299
ALA A 327
ILE A 331
B4P  A 349 (-3.5A)
B4P  A 349 (-3.6A)
None
B4P  A 349 (-3.3A)
B4P  A 349 (-3.3A)
B4P  A 349 (-3.4A)
None
0.56A 1bx4A-3looA:
51.0
1bx4A-3looA:
48.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE


(Streptomyces
avermitilis)
PF00106
(adh_short)
5 GLY A  18
VAL A  10
ILE A 232
ALA A  24
ALA A  25
None
0.83A 1bx4A-3m1aA:
6.2
1bx4A-3m1aA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0r RESPONSE REGULATOR

(Caulobacter
vibrioides)
PF00072
(Response_reg)
6 THR A 141
VAL A 143
ILE A 238
GLY A 252
ALA A 254
ILE A 217
None
1.42A 1bx4A-3n0rA:
undetectable
1bx4A-3n0rA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF00294
(PfkB)
9 THR A 264
THR A 270
VAL A 283
GLN A 288
ALA A 297
GLY A 298
HIS A 323
ALA A 326
ILE A 330
AP5  A 346 (-3.6A)
AP5  A 346 (-4.5A)
AP5  A 346 (-4.1A)
AP5  A 346 (-3.1A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 (-3.8A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.9A)
0.58A 1bx4A-3otxA:
49.7
1bx4A-3otxA:
40.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA


(Sulfolobus
solfataricus)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
6 THR A 365
ILE A 138
ALA A 108
GLY A 107
ALA A 109
ILE A 139
None
1.42A 1bx4A-3penA:
undetectable
1bx4A-3penA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
5 GLY A  61
ARG A  60
GLY A  46
ALA A  75
ILE A  81
None
0.94A 1bx4A-3ph3A:
undetectable
1bx4A-3ph3A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz6 HPCH/HPAI ALDOLASE

(Desulfitobacterium
hafniense)
PF03328
(HpcH_HpaI)
6 THR A  99
THR A 103
VAL A 165
ILE A 156
GLY A  93
ILE A 147
None
1.36A 1bx4A-3qz6A:
undetectable
1bx4A-3qz6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus)
PF00294
(PfkB)
5 THR A 222
GLY A 224
THR A 228
ALA A 252
GLY A 253
None
0.49A 1bx4A-3ry7A:
28.3
1bx4A-3ry7A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti)
PF00294
(PfkB)
5 THR A 245
ALA A 276
GLY A 277
ALA A 305
ILE A 309
ADP  A 354 (-3.3A)
ADP  A 354 (-3.4A)
ADP  A 354 (-3.4A)
ADP  A 354 (-2.7A)
None
0.69A 1bx4A-3uboA:
39.3
1bx4A-3uboA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uho GLUTAMATE RACEMASE

(Campylobacter
jejuni)
PF01177
(Asp_Glu_race)
6 ILE A  67
ALA A  95
GLY A  96
HIS A 202
ALA A 206
ILE A 207
None
None
None
None
EDO  A 264 (-3.3A)
None
1.23A 1bx4A-3uhoA:
2.8
1bx4A-3uhoA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Deinococcus
radiodurans)
PF01063
(Aminotran_4)
5 THR A 309
GLY A 300
ILE A 236
ALA A 239
ILE A 226
None
0.88A 1bx4A-3uzbA:
undetectable
1bx4A-3uzbA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
8 THR A 265
GLY A 267
VAL A 286
ILE A 294
ALA A 300
GLY A 301
ALA A 329
ILE A 333
None
0.62A 1bx4A-3vasA:
49.7
1bx4A-3vasA:
36.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
5 THR A 265
ILE A 294
GLY A 299
ALA A 329
ILE A 333
None
None
ADN  A 401 ( 3.8A)
None
None
0.94A 1bx4A-3vasA:
49.7
1bx4A-3vasA:
36.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)


(Pseudomonas
aeruginosa)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 GLY A 256
THR A 293
ILE A 200
HIS A 108
ILE A 113
None
0.85A 1bx4A-3wwzA:
3.0
1bx4A-3wwzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP


(Corynebacterium
glutamicum)
PF02028
(BCCT)
5 GLY A 382
VAL A 475
ILE A 388
ALA A 148
GLY A 149
None
0.91A 1bx4A-4ainA:
undetectable
1bx4A-4ainA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE


(Clostridioides
difficile)
PF00590
(TP_methylase)
5 THR A 186
VAL A 226
GLY A 180
ALA A 155
ILE A 151
None
0.95A 1bx4A-4e16A:
undetectable
1bx4A-4e16A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE


(Oceanicola
granulosus)
PF00294
(PfkB)
5 GLY A 225
VAL A 242
ALA A 254
GLY A 255
ALA A 283
None
0.35A 1bx4A-4e69A:
30.5
1bx4A-4e69A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE


(Oenococcus oeni)
PF00465
(Fe-ADH)
5 GLY A 145
ILE A 227
ALA A 254
GLY A 255
HIS A 267
None
None
None
None
NI  A 501 (-3.4A)
0.91A 1bx4A-4fr2A:
3.3
1bx4A-4fr2A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iil MEMBRANE LIPOPROTEIN
TPN38(B)


(Treponema
pallidum)
PF02608
(Bmp)
5 VAL A  26
GLN A 121
ILE A 164
GLY A 154
ILE A 213
RBF  A 401 (-3.9A)
RBF  A 401 (-3.3A)
RBF  A 401 ( 4.7A)
None
RBF  A 401 (-3.7A)
0.89A 1bx4A-4iilA:
4.9
1bx4A-4iilA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Rickettsia
rickettsii)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 202
ILE A 366
ALA A  93
GLY A  90
ALA A  94
None
0.92A 1bx4A-4jgaA:
undetectable
1bx4A-4jgaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA


([Haemophilus]
ducreyi)
PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
5 GLY A 313
ARG A 312
ALA A 340
GLY A 341
ALA A 317
None
0.94A 1bx4A-4k3cA:
undetectable
1bx4A-4k3cA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
5 GLY A  22
ILE A   5
ALA A  55
GLY A  54
ILE A  35
None
0.68A 1bx4A-4lmpA:
4.0
1bx4A-4lmpA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 188
THR A 165
ALA A  77
ALA A 142
ILE A 146
None
0.82A 1bx4A-4ls5A:
undetectable
1bx4A-4ls5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9c BACTERIAL
TRANSFERASE
HEXAPEPTIDE (THREE
REPEATS) FAMILY
PROTEIN


(Acinetobacter
baumannii)
PF00132
(Hexapep)
5 GLY A 192
ALA A 152
GLY A 151
ALA A 149
ILE A 166
None
0.83A 1bx4A-4m9cA:
undetectable
1bx4A-4m9cA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Enterococcus
faecalis)
PF04095
(NAPRTase)
5 GLY A  55
ILE A 436
ALA A 177
ALA A 142
ILE A 180
None
GOL  A 504 ( 4.3A)
None
None
None
0.89A 1bx4A-4mzyA:
undetectable
1bx4A-4mzyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
5 THR A 223
GLY A 225
VAL A 243
GLY A 256
ALA A 284
None
0.58A 1bx4A-4pvvA:
27.5
1bx4A-4pvvA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 GLY A  18
ILE A  89
ALA A 113
GLY A 110
ALA A 114
ILE A 117
None
None
None
PO4  A 401 (-3.8A)
None
None
1.41A 1bx4A-4u39A:
6.9
1bx4A-4u39A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9p UPF0264 PROTEIN
MJ1099


(Methanocaldococcus
jannaschii)
PF04476
(4HFCP_synth)
5 GLY A 206
ILE A 194
ALA A 210
GLY A 209
ALA A 211
None
0.77A 1bx4A-4u9pA:
undetectable
1bx4A-4u9pA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB


(Brucella
abortus)
PF00294
(PfkB)
5 THR A 217
GLY A 219
ALA A 247
GLY A 248
ALA A 289
ANP  A 401 (-3.5A)
ANP  A 401 (-3.6A)
ANP  A 401 (-3.3A)
ANP  A 401 (-3.4A)
ANP  A 401 (-3.5A)
0.45A 1bx4A-4wjmA:
29.2
1bx4A-4wjmA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae)
PF00294
(PfkB)
6 THR A 220
GLY A 222
ALA A 250
GLY A 251
HIS A 276
ALA A 279
None
0.61A 1bx4A-4x8fA:
30.0
1bx4A-4x8fA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001)
PF01425
(Amidase)
6 THR A 142
GLY A 162
ILE A 188
ALA A 167
GLY A 166
ALA A 168
None
1.25A 1bx4A-4yjiA:
undetectable
1bx4A-4yjiA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE


(Chlamydomonas
reinhardtii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 GLY A 290
THR A 333
ILE A 234
HIS A 142
ILE A 147
None
0.91A 1bx4A-4zgsA:
3.1
1bx4A-4zgsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1


(Homo sapiens)
PF12859
(ANAPC1)
5 GLY A1258
ILE A1232
ALA A1298
GLY A1299
ALA A1297
None
0.94A 1bx4A-5a31A:
undetectable
1bx4A-5a31A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A,KTR
SYSTEM POTASSIUM
UPTAKE PROTEIN A


(Bacillus
subtilis)
PF02254
(TrkA_N)
5 GLY A  18
VAL A  11
ILE A 122
ALA A 275
ILE A 274
None
0.94A 1bx4A-5butA:
8.2
1bx4A-5butA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A,KTR
SYSTEM POTASSIUM
UPTAKE PROTEIN A


(Bacillus
subtilis)
PF02254
(TrkA_N)
5 GLY A 160
VAL A 153
ILE A 264
ALA A 133
ILE A 132
None
0.93A 1bx4A-5butA:
8.2
1bx4A-5butA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens)
PF00294
(PfkB)
5 THR A 235
GLY A 237
ALA A 267
GLY A 268
ALA A 298
ACP  A 401 (-3.2A)
ACP  A 401 (-3.3A)
ACP  A 401 (-3.5A)
ACP  A 401 (-3.4A)
ACP  A 401 (-3.3A)
0.49A 1bx4A-5c41A:
32.3
1bx4A-5c41A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE


(Clostridium
sporogenes)
PF01053
(Cys_Met_Meta_PP)
6 THR A 244
GLY A 239
ILE A 232
ALA A  91
GLY A  90
ALA A  85
None
1.17A 1bx4A-5dx5A:
3.8
1bx4A-5dx5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI


(Ruegeria
pomeroyi)
PF00107
(ADH_zinc_N)
5 GLY A 182
ILE A 198
ALA A 158
GLY A 157
ALA A 159
None
None
None
BR  A 401 (-3.6A)
None
0.95A 1bx4A-5gxfA:
4.2
1bx4A-5gxfA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6j PIERISIN-1

(Pieris rapae)
no annotation 6 THR A 115
ILE A  28
ALA A  15
GLY A 171
ALA A  14
ILE A  12
None
1.27A 1bx4A-5h6jA:
undetectable
1bx4A-5h6jA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4


(Shewanella
oneidensis)
PF00724
(Oxidored_FMN)
5 GLY A 178
VAL A 171
ILE A 181
GLY A 227
ILE A 222
None
0.92A 1bx4A-5k1uA:
undetectable
1bx4A-5k1uA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE


(Giardia
intestinalis)
PF07992
(Pyr_redox_2)
5 THR A  32
GLY A  10
ALA A  21
GLY A  22
ALA A 303
None
0.82A 1bx4A-5m5jA:
undetectable
1bx4A-5m5jA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN BETA
SUBUNIT


(Gracilaria
chilensis)
PF00502
(Phycobilisome)
6 THR B  33
GLY B  29
ARG B  28
ALA B   4
GLY B  99
ILE B   5
None
1.41A 1bx4A-5tjfB:
undetectable
1bx4A-5tjfB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Burkholderia
multivorans)
PF00171
(Aldedh)
6 THR A 321
THR A 358
ILE A 349
ALA A 328
ALA A 371
ILE A 372
None
1.23A 1bx4A-5ujuA:
undetectable
1bx4A-5ujuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1


(Homo sapiens)
no annotation 5 GLY C 880
ILE C 872
GLY C 845
ALA C 847
ILE C 850
None
0.92A 1bx4A-5zyaC:
undetectable
1bx4A-5zyaC:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6alk -

(-)
no annotation 5 ILE A  56
ALA A  37
GLY A 142
ALA A  34
ILE A  38
None
0.92A 1bx4A-6alkA:
undetectable
1bx4A-6alkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0p PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii)
no annotation 5 VAL A  69
ALA A 173
GLY A 172
ALA A 174
ILE A 143
None
0.93A 1bx4A-6d0pA:
undetectable
1bx4A-6d0pA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2


(Sulfobacillus)
no annotation 6 GLY B 140
ARG B 169
THR B 132
ALA B 146
ALA B 115
ILE B 112
None
1.43A 1bx4A-6eqnB:
2.4
1bx4A-6eqnB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2


(Sulfobacillus)
no annotation 5 GLY B 263
ALA B 268
HIS B 110
ALA B 269
ILE B 233
PLP  B 501 (-3.5A)
None
PLP  B 501 (-3.9A)
None
None
0.95A 1bx4A-6eqnB:
2.4
1bx4A-6eqnB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2


(Sulfobacillus)
no annotation 6 THR B 132
GLY B 140
ARG B 169
ALA B 146
ALA B 115
ILE B 112
None
1.39A 1bx4A-6eqnB:
2.4
1bx4A-6eqnB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE


(Pyrococcus
abyssi)
no annotation 5 GLY A 172
THR A 175
ILE A   4
ALA A  30
ILE A 169
None
0.95A 1bx4A-6f8yA:
undetectable
1bx4A-6f8yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)


(Homo sapiens)
no annotation 5 ARG A  40
VAL A  33
ILE A 146
ALA A 357
ILE A 181
None
0.84A 1bx4A-6fn1A:
undetectable
1bx4A-6fn1A:
14.57