SIMILAR PATTERNS OF AMINO ACIDS FOR 1BX4_A_ADNA350_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1atj | PEROXIDASE C1A (Armoraciarusticana) |
PF00141(peroxidase) | 3 | LEU A 166SER A 161ASN A 158 | HEM A 350 (-4.0A)NoneNone | 0.68A | 1bx4A-1atjA:undetectable | 1bx4A-1atjA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4o | DNA NUCLEOTIDEEXCISION REPAIRENZYME UVRB (Thermusthermophilus) |
PF00271(Helicase_C)PF04851(ResIII)PF12344(UvrB) | 3 | LEU A 342SER A 140ASN A 63 | None | 0.70A | 1bx4A-1c4oA:0.2 | 1bx4A-1c4oA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dc1 | BSOBI RESTRICTIONENDONUCLEASE (Geobacillusstearothermophilus) |
PF09194(Endonuc-BsobI) | 3 | LEU A 114SER A 76ASN A 96 | None | 0.56A | 1bx4A-1dc1A:undetectable | 1bx4A-1dc1A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jwe | PROTEIN (DNABHELICASE) (Escherichiacoli) |
PF00772(DnaB) | 3 | LEU A 42SER A 35ASN A 117 | None | 0.77A | 1bx4A-1jweA:undetectable | 1bx4A-1jweA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1le8 | MATING-TYPE PROTEINALPHA-2 (Saccharomycescerevisiae) |
PF00046(Homeobox) | 3 | LEU B 162SER B 172ASN B 178 | None | 0.79A | 1bx4A-1le8B:undetectable | 1bx4A-1le8B:12.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lgf | P450 MONOOXYGENASE (Amycolatopsisorientalis) |
PF00067(p450) | 3 | LEU A 247SER A 242ASN A 240 | NoneNoneHEM A 430 (-3.9A) | 0.82A | 1bx4A-1lgfA:undetectable | 1bx4A-1lgfA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lpj | RETINOL-BINDINGPROTEIN IV, CELLULAR (Homo sapiens) |
PF00061(Lipocalin) | 3 | LEU A 117SER A 13ASN A 15 | None | 0.78A | 1bx4A-1lpjA:undetectable | 1bx4A-1lpjA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb8 | WBPP (Pseudomonasaeruginosa) |
PF01370(Epimerase) | 3 | LEU A 316SER A 311ASN A 262 | None | 0.79A | 1bx4A-1sb8A:5.2 | 1bx4A-1sb8A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1svv | THREONINE ALDOLASE (Leishmaniamajor) |
PF01212(Beta_elim_lyase) | 3 | LEU A 191SER A 193ASN A 298 | None | 0.77A | 1bx4A-1svvA:3.7 | 1bx4A-1svvA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u3d | CRYPTOCHROME 1APOPROTEIN (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | LEU A 233SER A 236ASN A 288 | None | 0.59A | 1bx4A-1u3dA:2.9 | 1bx4A-1u3dA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w18 | LEVANSUCRASE (Gluconacetobacterdiazotrophicus) |
PF02435(Glyco_hydro_68) | 3 | LEU A 139SER A 148ASN A 542 | None | 0.82A | 1bx4A-1w18A:undetectable | 1bx4A-1w18A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wj5 | HYPOTHETICAL PROTEIN(RIKEN CDNA0610009H20) (Mus musculus) |
PF09170(STN1_2) | 3 | LEU A 51SER A 22ASN A 82 | None | 0.75A | 1bx4A-1wj5A:undetectable | 1bx4A-1wj5A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wvt | HYPOTHETICAL PROTEINST2180 (Sulfurisphaeratokodaii) |
PF01923(Cob_adeno_trans) | 3 | LEU A 46SER A 110ASN A 163 | None | 0.78A | 1bx4A-1wvtA:undetectable | 1bx4A-1wvtA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xxg | ENTEROTOXIN (Staphylococcusaureus) |
PF01123(Stap_Strp_toxin)PF02876(Stap_Strp_tox_C) | 3 | LEU A 50SER A 47ASN A 68 | None | 0.66A | 1bx4A-1xxgA:undetectable | 1bx4A-1xxgA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yzf | LIPASE/ACYLHYDROLASE (Enterococcusfaecalis) |
PF13472(Lipase_GDSL_2) | 3 | LEU A 109SER A 104ASN A 143 | None | 0.72A | 1bx4A-1yzfA:3.0 | 1bx4A-1yzfA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akc | CLASS A NONSPECIFICACID PHOSPHATASEPHON (Salmonellaenterica) |
PF01569(PAP2) | 3 | LEU A 169SER A 88ASN A 238 | None | 0.82A | 1bx4A-2akcA:undetectable | 1bx4A-2akcA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b0t | NADP ISOCITRATEDEHYDROGENASE (Corynebacteriumglutamicum) |
PF03971(IDH) | 3 | LEU A 14SER A 713ASN A 715 | None | 0.77A | 1bx4A-2b0tA:undetectable | 1bx4A-2b0tA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f3o | PYRUVATEFORMATE-LYASE 2 (Archaeoglobusfulgidus) |
PF01228(Gly_radical)PF02901(PFL-like) | 3 | LEU A 101SER A 20ASN A 71 | None | 0.68A | 1bx4A-2f3oA:undetectable | 1bx4A-2f3oA:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f7l | 455AA LONGHYPOTHETICALPHOSPHO-SUGAR MUTASE (Sulfurisphaeratokodaii) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 3 | LEU A 419SER A 287ASN A 328 | None | 0.70A | 1bx4A-2f7lA:undetectable | 1bx4A-2f7lA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fge | ZINC METALLOPROTEASE(INSULINASE FAMILY) (Arabidopsisthaliana) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 3 | LEU A 511SER A 165ASN A 162 | None | 0.80A | 1bx4A-2fgeA:undetectable | 1bx4A-2fgeA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jf4 | PERIPLASMICTREHALASE (Escherichiacoli) |
PF01204(Trehalase) | 3 | LEU A 168SER A 161ASN A 183 | None | 0.73A | 1bx4A-2jf4A:undetectable | 1bx4A-2jf4A:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lqn | CRK-LIKE PROTEIN (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07653(SH3_2) | 3 | LEU A 28SER A 59ASN A 55 | None | 0.77A | 1bx4A-2lqnA:undetectable | 1bx4A-2lqnA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lsh | SPORE-WALL FUNGALHYDROPHOBIN DEWA (Aspergillusnidulans) |
PF01185(Hydrophobin) | 3 | LEU A 50SER A 45ASN A 43 | None | 0.81A | 1bx4A-2lshA:undetectable | 1bx4A-2lshA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lwy | BACTERIALINTEIN-LIKE DOMAIN (Ruminiclostridiumthermocellum) |
PF07591(PT-HINT) | 3 | LEU A 90SER A 92ASN A 129 | None | 0.84A | 1bx4A-2lwyA:undetectable | 1bx4A-2lwyA:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ok8 | PUTATIVEFERREDOXIN--NADPREDUCTASE (Plasmodiumfalciparum) |
PF00175(NAD_binding_1) | 3 | LEU A 226SER A 222ASN A 30 | None | 0.75A | 1bx4A-2ok8A:4.4 | 1bx4A-2ok8A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p9w | MAL S 1 ALLERGENICPROTEIN (Malasseziasympodialis) |
no annotation | 3 | LEU A 230SER A 290ASN A 287 | None | 0.67A | 1bx4A-2p9wA:undetectable | 1bx4A-2p9wA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2taa | TAKA-AMYLASE A (Aspergillusoryzae) |
PF00128(Alpha-amylase)PF09260(DUF1966) | 3 | LEU A 114SER A 105ASN A 197 | None | 0.84A | 1bx4A-2taaA:undetectable | 1bx4A-2taaA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhe | ACETYLTRANSFERASE (Campylobacterjejuni) |
PF00132(Hexapep) | 3 | LEU A 153SER A 169ASN A 150 | None | 0.82A | 1bx4A-2vheA:undetectable | 1bx4A-2vheA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wfo | GLYCOPROTEIN 1 (Machupomammarenavirus) |
PF00798(Arena_glycoprot) | 3 | LEU A 132SER A 141ASN A 137 | NoneNoneNAG A1243 (-1.8A) | 0.79A | 1bx4A-2wfoA:undetectable | 1bx4A-2wfoA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x3l | ORN/LYS/ARGDECARBOXYLASE FAMILYPROTEIN (Staphylococcusaureus) |
PF01276(OKR_DC_1)PF03711(OKR_DC_1_C) | 3 | LEU A 222SER A 220ASN A 79 | NonePLP A1211 (-3.4A)None | 0.83A | 1bx4A-2x3lA:3.0 | 1bx4A-2x3lA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ybx | PHOSPHATIDYLINOSITOL-5-PHOSPHATE4-KINASE TYPE-2ALPHA (Homo sapiens) |
PF01504(PIP5K) | 3 | LEU A 122SER A 137ASN A 198 | None | 0.84A | 1bx4A-2ybxA:undetectable | 1bx4A-2ybxA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ciy | TOLL-LIKE RECEPTOR 3 (Mus musculus) |
PF00560(LRR_1)PF13855(LRR_8) | 3 | LEU A 321SER A 295ASN A 291 | NoneNoneNAG A2911 (-1.9A) | 0.76A | 1bx4A-3ciyA:undetectable | 1bx4A-3ciyA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctt | MALTASE-GLUCOAMYLASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 3 | LEU A 151SER A 230ASN A 176 | None | 0.73A | 1bx4A-3cttA:undetectable | 1bx4A-3cttA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7w | D-ALANINE--POLY(PHOSPHORIBITOL) LIGASESUBUNIT 1 (Bacillussubtilis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | LEU A 27SER A 22ASN A 189 | None | 0.77A | 1bx4A-3e7wA:undetectable | 1bx4A-3e7wA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fnk | CELLULOSOMALSCAFFOLDIN ADAPTORPROTEIN B (Acetivibriocellulolyticus) |
PF00963(Cohesin) | 3 | LEU A 98SER A 68ASN A 66 | None | 0.57A | 1bx4A-3fnkA:undetectable | 1bx4A-3fnkA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fzy | RTX TOXIN RTXA (Vibrio cholerae) |
PF11713(Peptidase_C80) | 3 | LEU A3492SER A3494ASN A3438 | None | 0.76A | 1bx4A-3fzyA:undetectable | 1bx4A-3fzyA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcd | RTX TOXIN RTXA (Vibrio cholerae) |
PF11713(Peptidase_C80) | 3 | LEU A 64SER A 66ASN A 10 | None | 0.77A | 1bx4A-3gcdA:undetectable | 1bx4A-3gcdA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gk3 | ACETOACETYL-COAREDUCTASE (Burkholderiapseudomallei) |
PF13561(adh_short_C2) | 3 | LEU A 222SER A 183ASN A 138 | None | 0.66A | 1bx4A-3gk3A:6.6 | 1bx4A-3gk3A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjr | EXTRACELLULAR SERINEPROTEASE (Aeromonassobria) |
PF00082(Peptidase_S8)PF01483(P_proprotein) | 3 | LEU A 486SER A 509ASN A 243 | None | 0.78A | 1bx4A-3hjrA:undetectable | 1bx4A-3hjrA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ks7 | PUTATIVE PUTATIVEPNGASE F (Bacteroidesfragilis) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 3 | LEU A 278SER A 302ASN A 310 | None | 0.83A | 1bx4A-3ks7A:undetectable | 1bx4A-3ks7A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8q | CELLULOSOMALSCAFFOLDIN ADAPTORPROTEIN B (Acetivibriocellulolyticus) |
PF00963(Cohesin) | 3 | LEU A 261SER A 231ASN A 229 | None | 0.70A | 1bx4A-3l8qA:undetectable | 1bx4A-3l8qA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lp8 | PHOSPHORIBOSYLAMINE-GLYCINE LIGASE (Ehrlichiachaffeensis) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 3 | LEU A 297SER A 295ASN A 383 | None | 0.71A | 1bx4A-3lp8A:undetectable | 1bx4A-3lp8A:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m2p | UDP-N-ACETYLGLUCOSAMINE 4-EPIMERASE (Bacillus cereus) |
PF01370(Epimerase) | 3 | LEU A 271SER A 266ASN A 120 | None | 0.71A | 1bx4A-3m2pA:5.7 | 1bx4A-3m2pA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m2p | UDP-N-ACETYLGLUCOSAMINE 4-EPIMERASE (Bacillus cereus) |
PF01370(Epimerase) | 3 | LEU A 271SER A 266ASN A 221 | None | 0.74A | 1bx4A-3m2pA:5.7 | 1bx4A-3m2pA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mca | ELONGATION FACTOR 1ALPHA-LIKE PROTEINPROTEIN DOM34 (Schizosaccharomycespombe) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03463(eRF1_1)PF03464(eRF1_2)PF03465(eRF1_3) | 3 | LEU A 517SER A 579ASN B 254 | None | 0.76A | 1bx4A-3mcaA:undetectable | 1bx4A-3mcaA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-1B (Homo sapiens) |
PF07714(Pkinase_Tyr)PF08515(TGF_beta_GS) | 3 | LEU A 463SER A 459ASN A 455 | None | 0.83A | 1bx4A-3mdyA:undetectable | 1bx4A-3mdyA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3obf | PUTATIVETRANSCRIPTIONALREGULATOR, ICLRFAMILY (Paenarthrobacteraurescens) |
PF01614(IclR) | 3 | LEU A 193SER A 188ASN A 238 | None | 0.65A | 1bx4A-3obfA:undetectable | 1bx4A-3obfA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4g | ANTIFREEZE PROTEIN (Marinomonasprimoryensis) |
no annotation | 3 | LEU A 50SER A 47ASN A 64 | None | 0.79A | 1bx4A-3p4gA:undetectable | 1bx4A-3p4gA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pyg | 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE (Mycobacteriumtuberculosis) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 3 | LEU A 52SER A 90ASN A 48 | None | 0.83A | 1bx4A-3pygA:undetectable | 1bx4A-3pygA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qki | GLUCOSE-6-PHOSPHATEISOMERASE (Plasmodiumfalciparum) |
PF00342(PGI) | 3 | LEU A 503SER A 433ASN A 176 | None | 0.84A | 1bx4A-3qkiA:undetectable | 1bx4A-3qkiA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qtd | PMBA PROTEIN (Pseudomonasaeruginosa) |
PF01523(PmbA_TldD) | 3 | LEU A 338SER A 332ASN A 343 | None | 0.76A | 1bx4A-3qtdA:undetectable | 1bx4A-3qtdA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgg | HYPOTHETICALHYDROLASE (Bacteroidesthetaiotaomicron) |
PF14323(GxGYxYP_C)PF16216(GxGYxYP_N) | 3 | LEU A 427SER A 330ASN A 334 | None | 0.80A | 1bx4A-3sggA:undetectable | 1bx4A-3sggA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t1b | TRANSCRIPTIONALREGULATOR, LYSRFAMILY (Vibrio cholerae) |
PF00126(HTH_1)PF03466(LysR_substrate) | 3 | LEU A 164SER A 258ASN A 201 | None | 0.75A | 1bx4A-3t1bA:undetectable | 1bx4A-3t1bA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tw8 | DENNDOMAIN-CONTAININGPROTEIN 1B (Homo sapiens) |
PF02141(DENN)PF03455(dDENN)PF03456(uDENN) | 3 | LEU A 203SER A 201ASN A 64 | None | 0.82A | 1bx4A-3tw8A:undetectable | 1bx4A-3tw8A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) |
PF00708(Acylphosphatase)PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 3 | LEU A 710SER A 700ASN A 733 | NoneNoneAP2 A 806 (-4.9A) | 0.50A | 1bx4A-3vthA:undetectable | 1bx4A-3vthA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vzg | ZYMOGEN GRANULEMEMBRANE PROTEIN 16 (Homo sapiens) |
PF01419(Jacalin) | 3 | LEU A 133SER A 23ASN A 136 | None | 0.58A | 1bx4A-3vzgA:undetectable | 1bx4A-3vzgA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4egt | MAJOR CAPSID PROTEINVP60 (Rabbithemorrhagicdisease virus) |
PF00915(Calici_coat) | 3 | LEU A 547SER A 465ASN A 253 | None | 0.71A | 1bx4A-4egtA:undetectable | 1bx4A-4egtA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fb5 | PROBABLEOXIDOREDUCTASEPROTEIN (Rhizobium etli) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | LEU A 239SER A 244ASN A 154 | None | 0.84A | 1bx4A-4fb5A:undetectable | 1bx4A-4fb5A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gba | DCN1-LIKE PROTEIN 3 (Homo sapiens) |
PF03556(Cullin_binding) | 3 | LEU A 191SER A 239ASN A 244 | None | 0.78A | 1bx4A-4gbaA:undetectable | 1bx4A-4gbaA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hr6 | LECTIN (Trichosanthesanguina) |
PF00652(Ricin_B_lectin) | 3 | LEU C 105SER C 107ASN C 115 | None | 0.79A | 1bx4A-4hr6C:undetectable | 1bx4A-4hr6C:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0m | SERINE/THREONINE-PROTEIN KINASEBRI1-LIKE 1 (Arabidopsisthaliana) |
PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 3 | LEU A 573SER A 569ASN A 545 | None | 0.84A | 1bx4A-4j0mA:undetectable | 1bx4A-4j0mA:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcs | ENOYL-COAHYDRATASE/ISOMERASE (Cupriavidusmetallidurans) |
PF00378(ECH_1) | 3 | LEU A 52SER A 54ASN A 18 | None | 0.62A | 1bx4A-4jcsA:undetectable | 1bx4A-4jcsA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jnq | THIOREDOXINREDUCTASE (Brucellamelitensis) |
PF07992(Pyr_redox_2) | 3 | LEU A 192SER A 198ASN A 196 | None | 0.80A | 1bx4A-4jnqA:undetectable | 1bx4A-4jnqA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jvs | PUTATIVEUNCHARACTERIZEDPROTEIN (Legionelladrancourtii) |
no annotation | 3 | LEU A 576SER A 542ASN A 569 | ACY A 701 ( 4.5A)NoneNone | 0.80A | 1bx4A-4jvsA:undetectable | 1bx4A-4jvsA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6c | ACETOACETYL-COAREDUCTASE (Burkholderiacenocepacia) |
PF13561(adh_short_C2) | 3 | LEU A 221SER A 182ASN A 137 | None | 0.72A | 1bx4A-4k6cA:3.4 | 1bx4A-4k6cA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l1f | ACYL-COADEHYDROGENASE DOMAINPROTEIN (Acidaminococcusfermentans) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 3 | LEU A 24SER A 77ASN A 355 | None | 0.74A | 1bx4A-4l1fA:undetectable | 1bx4A-4l1fA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n54 | INOSITOLDEHYDROGENASE (Lactobacilluscasei) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | LEU A 82SER A 78ASN A 175 | NoneNAI A 401 (-3.1A)None | 0.78A | 1bx4A-4n54A:4.8 | 1bx4A-4n54A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pph | CONGLUTIN GAMMA (Lupinusangustifolius) |
PF14541(TAXi_C)PF14543(TAXi_N) | 3 | LEU A 27SER A 24ASN A 158 | None | 0.76A | 1bx4A-4pphA:undetectable | 1bx4A-4pphA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6r | SPHINGOSINE-1-PHOSPHATE LYASE 1 (Homo sapiens) |
PF00282(Pyridoxal_deC) | 3 | LEU A 463SER A 482ASN A 475 | None | 0.77A | 1bx4A-4q6rA:undetectable | 1bx4A-4q6rA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r04 | TOXIN A (Clostridioidesdifficile) |
PF11713(Peptidase_C80)PF12918(TcdB_N)PF12919(TcdA_TcdB)PF12920(TcdA_TcdB_pore) | 3 | LEU A 799SER A 801ASN A1801 | None | 0.82A | 1bx4A-4r04A:undetectable | 1bx4A-4r04A:9.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rav | SINGLE-CHAIN FV, VL (Homo sapiens) |
PF07686(V-set) | 3 | LEU B 176SER B 192ASN B 189 | None | 0.69A | 1bx4A-4ravB:undetectable | 1bx4A-4ravB:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uph | SULFATASE (SULFURICESTER HYDROLASE)PROTEIN (Agrobacteriumtumefaciens) |
PF00884(Sulfatase)PF16347(DUF4976) | 3 | LEU A 89SER A 87ASN A 85 | NoneNoneDDZ A 64 ( 4.0A) | 0.74A | 1bx4A-4uphA:undetectable | 1bx4A-4uphA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wi0 | CELLULOSOMALSCAFFOLDIN ADAPTORPROTEIN B (Acetivibriocellulolyticus) |
PF00963(Cohesin) | 3 | LEU A 91SER A 61ASN A 59 | None | 0.63A | 1bx4A-4wi0A:undetectable | 1bx4A-4wi0A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wui | N-(5'-PHOSPHORIBOSYL)ANTHRANILATEISOMERASE (Jonesiadenitrificans) |
PF00697(PRAI) | 3 | LEU A 106SER A 109ASN A 111 | None | 0.79A | 1bx4A-4wuiA:undetectable | 1bx4A-4wuiA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xru | HEN1 (Capnocytophagagingivalis) |
no annotation | 3 | LEU C 15SER C 160ASN C 166 | None | 0.70A | 1bx4A-4xruC:3.5 | 1bx4A-4xruC:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yxf | MUPS (Pseudomonasfluorescens) |
PF13561(adh_short_C2) | 3 | LEU A 233SER A 195ASN A 150 | None | 0.53A | 1bx4A-4yxfA:3.3 | 1bx4A-4yxfA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8t | AVRRXO1-ORF1 (Xanthomonasoryzae) |
no annotation | 3 | LEU A 131SER A 218ASN A 191 | None | 0.78A | 1bx4A-4z8tA:undetectable | 1bx4A-4z8tA:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a6s | ENDOLYSIN (Clostridiumphage phiCTP1) |
PF01183(Glyco_hydro_25) | 3 | LEU A 10SER A 173ASN A 13 | None | 0.77A | 1bx4A-5a6sA:undetectable | 1bx4A-5a6sA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a99 | POLYHEDRIN (Operophterabrumatacypovirus 19) |
no annotation | 3 | LEU A 37SER A 186ASN A 62 | None | 0.83A | 1bx4A-5a99A:undetectable | 1bx4A-5a99A:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j44 | SERINE PROTEASE SEPAAUTOTRANSPORTER (Shigellaflexneri) |
PF02395(Peptidase_S6) | 3 | LEU A 859SER A 811ASN A 871 | None | 0.82A | 1bx4A-5j44A:undetectable | 1bx4A-5j44A:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ke1 | OUTER MEMBRANEPROTEIN ICSAAUTOTRANSPORTER (Shigellaflexneri) |
PF03212(Pertactin)PF12951(PATR) | 3 | LEU A 535SER A 530ASN A 548 | None | 0.77A | 1bx4A-5ke1A:undetectable | 1bx4A-5ke1A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzs | PUTATIVE CELLSURFACE PROTEIN,SIMILAR TOINTERNALIN PROTEINS (Listeriamonocytogenes) |
PF12354(Internalin_N)PF13855(LRR_8) | 3 | LEU A 93SER A 89ASN A 87 | None | 0.58A | 1bx4A-5kzsA:undetectable | 1bx4A-5kzsA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5li4 | TAIL SHEATH PROTEIN (Staphylococcusphage 812) |
no annotation | 3 | LEU A 62SER A 57ASN A 81 | None | 0.84A | 1bx4A-5li4A:undetectable | 1bx4A-5li4A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lpc | VANADIUM-DEPENDENTBROMOPEROXIDASE (Acaryochlorismarina) |
no annotation | 3 | LEU A 268SER A 189ASN A 556 | None | 0.77A | 1bx4A-5lpcA:undetectable | 1bx4A-5lpcA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m23 | WD REPEAT-CONTAININGPROTEIN 5 (Homo sapiens) |
PF00400(WD40) | 3 | LEU A 101SER A 97ASN A 138 | None | 0.76A | 1bx4A-5m23A:undetectable | 1bx4A-5m23A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nij | VACUOLAR-PROCESSINGENZYME GAMMA-ISOZYME (Arabidopsisthaliana) |
no annotation | 3 | LEU A 183SER A 175ASN A 72 | NoneSNN A 176 ( 3.4A)CIT A 502 (-3.8A) | 0.82A | 1bx4A-5nijA:3.0 | 1bx4A-5nijA:13.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5obt | VACUOLAR-PROCESSINGENZYME GAMMA-ISOZYME (Arabidopsisthaliana) |
no annotation | 3 | LEU A 183SER A 175ASN A 72 | NoneSNN A 176 ( 3.2A)None | 0.80A | 1bx4A-5obtA:3.1 | 1bx4A-5obtA:13.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ogl | UNDECAPRENYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEINGLYCOTRANSFERASE (Campylobacterlari) |
no annotation | 3 | LEU A 661SER A 624ASN A 620 | None | 0.74A | 1bx4A-5oglA:undetectable | 1bx4A-5oglA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t3a | INTEGRASE (Visna-maedivirus) |
PF00665(rve) | 3 | LEU A 167SER A 176ASN A 172 | MES A 304 ( 4.4A)ACT A 301 (-3.0A)ACT A 301 (-4.0A) | 0.74A | 1bx4A-5t3aA:undetectable | 1bx4A-5t3aA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tpv | WLARA,TDP-FUCOSE-3,4-KETOISOMERASE (Campylobacterjejuni) |
PF05523(FdtA) | 3 | LEU A 106SER A 64ASN A 99 | None | 0.81A | 1bx4A-5tpvA:undetectable | 1bx4A-5tpvA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tru | CYTOTOXICT-LYMPHOCYTE PROTEIN4 (Homo sapiens) |
PF07686(V-set) | 3 | LEU c 79SER c 72ASN c 75 | None | 0.81A | 1bx4A-5truc:undetectable | 1bx4A-5truc:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xd7 | 3,6-ANHYDRO-ALPHA-L-GALACTONATECYCLOISOMERASE (Vibrio sp. EJY3) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | LEU A 318SER A 308ASN A 133 | None | 0.69A | 1bx4A-5xd7A:undetectable | 1bx4A-5xd7A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y8p | PROBABLE3-HYDROXYISOBUTYRATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
no annotation | 3 | LEU A 279SER A 237ASN A 242 | None | 0.77A | 1bx4A-5y8pA:undetectable | 1bx4A-5y8pA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zqj | BETA-XYLOSIDASE (Bacilluspumilus) |
no annotation | 3 | LEU A 365SER A 355ASN A 359 | None | 0.83A | 1bx4A-5zqjA:undetectable | 1bx4A-5zqjA:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6azt | ASPARAGINYLENDOPEPTIDASE 1 (Helianthusannuus) |
no annotation | 3 | LEU A 184SER A 176ASN A 73 | NoneSNN A 177 ( 3.5A)None | 0.78A | 1bx4A-6aztA:2.9 | 1bx4A-6aztA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b5c | KATANIN P60ATPASE-CONTAININGSUBUNIT A-LIKE 1 (Homo sapiens) |
no annotation | 3 | LEU A 389SER A 416ASN A 422 | None | 0.67A | 1bx4A-6b5cA:undetectable | 1bx4A-6b5cA:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c0b | TOXIN B (Clostridioidesdifficile) |
no annotation | 3 | LEU A1641SER A1677ASN A1734 | None | 0.72A | 1bx4A-6c0bA:undetectable | 1bx4A-6c0bA:11.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c0m | HEMAGGLUTININ-NEURAMINIDASE (Humanrespirovirus 3) |
no annotation | 3 | LEU A 484SER A 510ASN A 517 | None | 0.82A | 1bx4A-6c0mA:undetectable | 1bx4A-6c0mA:11.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d95 | - (-) |
no annotation | 3 | LEU A 471SER A 763ASN A 767 | None | 0.73A | 1bx4A-6d95A:undetectable | 1bx4A-6d95A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | PROTEIN CFT1 (Saccharomycescerevisiae) |
no annotation | 3 | LEU A 48SER A 504ASN A 507 | None | 0.76A | 1bx4A-6eojA:undetectable | 1bx4A-6eojA:13.71 |