SIMILAR PATTERNS OF AMINO ACIDS FOR 1BX4_A_ADNA350

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		7 ASN A  20
ASP A  24
GLY A  68
GLY A  69
ASN A  73
LEU A 142
ASP A 318
 ADN  A 375 ( 3.8A)
ADN  A 375 (-2.9A)
ADN  A 375 ( 4.5A)
ADN  A 375 (-2.9A)
ADN  A 375 ( 4.9A)
None
ADN  A 375 ( 3.1A)
 0.64A 1bx4A-1dgmA:
42.6		 1bx4A-1dgmA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		8 ASP A  24
LEU A  46
GLY A  68
GLY A  69
ASN A  73
CYH A 127
LEU A 142
ASP A 318
 ADN  A 375 (-2.9A)
None
ADN  A 375 ( 4.5A)
ADN  A 375 (-2.9A)
ADN  A 375 ( 4.9A)
ADN  A 375 ( 4.2A)
None
ADN  A 375 ( 3.1A)
 0.73A 1bx4A-1dgmA:
42.6		 1bx4A-1dgmA:
32.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		5 LEU A  46
GLY A  57
ALA A  49
LEU A  50
ASP A  60
 None
 0.87A 1bx4A-1drtA:
undetectable		 1bx4A-1drtA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Micrococcus
luteus) 		PF01255
(Prenyltransf) 		5 GLY A 149
GLY A 150
ASN A 206
ALA A 157
LEU A 184
 None
 0.93A 1bx4A-1f75A:
undetectable		 1bx4A-1f75A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 GLN A 457
GLY A 290
GLY A 291
ALA A 517
LEU A 521
 None
 0.93A 1bx4A-1jqoA:
undetectable		 1bx4A-1jqoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qot CHITIN BINDING
LECTIN, UEA-II

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 GLN A  23
GLY A 217
GLY A 216
ALA A  26
LEU A  34
 None
 0.98A 1bx4A-1qotA:
undetectable		 1bx4A-1qotA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 ASP A  16
GLY A  41
GLY A  42
ASN A  46
ASP A 255
 RIB  A 311 (-2.8A)
RIB  A 311 (-3.3A)
RIB  A 311 (-3.4A)
RIB  A 311 (-3.3A)
RIB  A 311 (-3.1A)
 0.35A 1bx4A-1rk2A:
32.4		 1bx4A-1rk2A:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suu DNA GYRASE SUBUNIT A

(Borreliella
burgdorferi) 		PF03989
(DNA_gyraseA_C) 		5 LEU A 705
GLY A 670
ALA A 756
LEU A 713
ASP A 699
 None
 1.00A 1bx4A-1suuA:
undetectable		 1bx4A-1suuA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE

(Salmonella
enterica) 		PF00294
(PfkB) 		5 ASP A  16
GLY A  30
GLY A  31
ASN A  35
ASP A 252
 AIS  A 402 (-2.5A)
AIS  A 402 ( 4.2A)
AIS  A 402 (-3.8A)
AIS  A 402 (-3.9A)
AIS  A 402 (-3.0A)
 0.34A 1bx4A-1tz6A:
30.0		 1bx4A-1tz6A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A 123
GLY A 266
GLY A 173
ALA A 298
ASP A 148
 None
 0.92A 1bx4A-1uxiA:
6.3		 1bx4A-1uxiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		5 LEU A 170
GLY A  33
GLY A  34
ASN A  38
ASP A 251
 None
 0.80A 1bx4A-1v19A:
32.1		 1bx4A-1v19A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 ASP A  14
GLY A  39
GLY A  40
ASN A  44
ASP A 246
 None
 0.59A 1bx4A-1vm7A:
29.6		 1bx4A-1vm7A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		6 ASN A   8
ASP A  12
GLY A  36
GLY A  37
ASN A  41
ASP A 249
 None
 1.09A 1bx4A-2abqA:
25.9		 1bx4A-2abqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		6 LEU A 171
GLY A  32
GLY A  33
ASN A  37
LEU A 139
ASP A 280
 None
 1.06A 1bx4A-2afbA:
30.3		 1bx4A-2afbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		6 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
 0.90A 1bx4A-2ajrA:
25.0		 1bx4A-2ajrA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btl INFECTIOUS
BRONCHITIS VIRUS
NUCLEOCAPSID PROTEIN

(Avian
coronavirus) 		PF00937
(Corona_nucleoca) 		5 ASP A 146
GLY A  53
GLY A  55
LEU A 142
PHE A  93
 None
 1.02A 1bx4A-2btlA:
undetectable		 1bx4A-2btlA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		5 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
 0.27A 1bx4A-2c49A:
28.7		 1bx4A-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		5 ASN A   8
ASP A  12
GLY A  36
GLY A  37
ASP A 255
 None
None
None
None
ATP  A 411 (-4.1A)
 1.00A 1bx4A-2f02A:
25.5		 1bx4A-2f02A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		5 ASP A  12
GLY A  36
GLY A  37
ASN A  41
ASP A 255
 None
None
None
None
ATP  A 411 (-4.1A)
 0.81A 1bx4A-2f02A:
25.5		 1bx4A-2f02A:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		8 ASN A  14
ASP A  18
GLY A  63
GLY A  64
ASN A  68
CYH A 123
LEU A 138
ASP A 300
 89I  A 500 (-4.0A)
None
None
89I  A 500 (-3.5A)
None
None
89I  A 500 (-4.4A)
None
 0.61A 1bx4A-2i6bA:
48.1		 1bx4A-2i6bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		7 ASN A  14
GLY A  63
GLY A  64
ASN A  68
LEU A 138
PHE A 170
ASP A 300
 89I  A 500 (-4.0A)
None
89I  A 500 (-3.5A)
None
89I  A 500 (-4.4A)
89I  A 500 (-3.8A)
None
 0.55A 1bx4A-2i6bA:
48.1		 1bx4A-2i6bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		9 ASP A  18
LEU A  40
GLY A  63
GLY A  64
ASN A  68
CYH A 123
ALA A 136
LEU A 138
ASP A 300
 None
89I  A 500 ( 4.8A)
None
89I  A 500 (-3.5A)
None
None
89I  A 500 (-3.4A)
89I  A 500 (-4.4A)
None
 0.58A 1bx4A-2i6bA:
48.1		 1bx4A-2i6bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		5 LEU A 263
GLY A  18
GLY A  19
ALA A 254
LEU A 258
 None
 0.96A 1bx4A-2jfwA:
3.8		 1bx4A-2jfwA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ASP A  12
GLY A  36
GLY A  37
ASN A  41
ASP A 249
 None
 0.67A 1bx4A-2jg5A:
25.3		 1bx4A-2jg5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ASP A  12
GLY A  36
GLY A  37
ASN A  41
ASP A 254
 None
 0.93A 1bx4A-2jgvA:
25.1		 1bx4A-2jgvA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ASP A  12
GLY A  36
GLY A  37
ASN A  41
CYH A  90
 None
 0.99A 1bx4A-2jgvA:
25.1		 1bx4A-2jgvA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 ASP A  13
GLY A  37
GLY A  38
ASN A  42
ASP A 253
 None
None
CL  A 403 (-3.5A)
None
None
 0.94A 1bx4A-2nwhA:
25.1		 1bx4A-2nwhA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2t MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 182
GLY A 146
GLY A 147
ALA A 176
LEU A 140
 None
 1.00A 1bx4A-2o2tA:
undetectable		 1bx4A-2o2tA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		5 LEU A  22
GLY A  10
ASN A 194
ALA A  19
LEU A  18
 None
 0.93A 1bx4A-2ppvA:
8.4		 1bx4A-2ppvA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvz PRPF METHYLACONITATE
ISOMERASE

(Shewanella
oneidensis) 		PF04303
(PrpF) 		5 GLN A  93
GLY A 322
GLY A 108
ASN A 109
PHE A  91
 CA  A1003 ( 4.7A)
EDO  A1005 (-3.6A)
EDO  A1005 (-3.8A)
EDO  A1005 (-4.0A)
None
 0.89A 1bx4A-2pvzA:
undetectable		 1bx4A-2pvzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.42A 1bx4A-2qcvA:
30.2		 1bx4A-2qcvA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		5 GLY A 196
GLY A 197
ASN A 253
ALA A 204
LEU A 231
 None
 0.96A 1bx4A-2vg2A:
undetectable		 1bx4A-2vg2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z84 UFM1-SPECIFIC
PROTEASE 1

(Mus musculus) 		PF07910
(Peptidase_C78) 		5 ASP A 152
LEU A 127
GLY A 149
GLY A 148
LEU A 121
 None
 0.93A 1bx4A-2z84A:
undetectable		 1bx4A-2z84A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 197
GLY A 228
ASN A  36
ALA A 199
LEU A 154
 None
 1.01A 1bx4A-3awkA:
undetectable		 1bx4A-3awkA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 ASP A  12
GLN A 169
GLY A  47
GLY A  48
ASP A 253
 AMP  A 501 (-2.9A)
AMP  A 501 (-3.4A)
AMP  A 501 ( 3.7A)
AMP  A 501 (-3.3A)
AMP  A 501 (-2.8A)
 0.69A 1bx4A-3b1rA:
27.3		 1bx4A-3b1rA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 ASP A  12
GLY A  47
GLY A  48
ASN A  52
ASP A 253
 AMP  A 501 (-2.9A)
AMP  A 501 ( 3.7A)
AMP  A 501 (-3.3A)
AMP  A 501 (-3.3A)
AMP  A 501 (-2.8A)
 0.38A 1bx4A-3b1rA:
27.3		 1bx4A-3b1rA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnb DNA-BINDING RESPONSE
REGULATOR, MERR
FAMILY

(Colwellia
psychrerythraea) 		PF00072
(Response_reg) 		5 LEU A 117
CYH A 167
ALA A 146
PHE A 127
ASP A 154
 None
 0.98A 1bx4A-3cnbA:
5.5		 1bx4A-3cnbA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cty THIOREDOXIN
REDUCTASE

(Thermoplasma
acidophilum) 		PF07992
(Pyr_redox_2) 		5 GLN A 253
LEU A 250
GLY A  28
GLY A  25
ASP A  46
 FAD  A1000 (-3.3A)
None
None
FAD  A1000 (-3.6A)
FAD  A1000 (-2.8A)
 0.90A 1bx4A-3ctyA:
undetectable		 1bx4A-3ctyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A 143
GLY A 288
GLY A 193
ASN A 165
ASP A 168
 None
 0.94A 1bx4A-3czmA:
2.4		 1bx4A-3czmA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		5 LEU A  21
GLY A  31
GLY A  63
ALA A  24
LEU A  25
 None
 0.93A 1bx4A-3e03A:
5.9		 1bx4A-3e03A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza sativa) 		PF07859
(Abhydrolase_3) 		5 ASP A 187
GLY A 186
GLY A 185
LEU A 352
PHE A 113
 None
 0.95A 1bx4A-3eblA:
undetectable		 1bx4A-3eblA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459

(Pyrococcus
horikoshii) 		PF00294
(PfkB) 		5 ASP A  13
GLY A  33
GLY A  34
ASN A  38
ASP A 247
 None
 0.36A 1bx4A-3ewmA:
29.1		 1bx4A-3ewmA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459

(Pyrococcus
horikoshii) 		PF00294
(PfkB) 		5 GLY A  33
GLY A  34
ASN A  38
LEU A 103
ASP A 247
 None
 0.89A 1bx4A-3ewmA:
29.1		 1bx4A-3ewmA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		5 ASN A 227
GLY A 231
GLY A 230
ALA A 286
LEU A 315
 LLP  A 226 ( 4.7A)
None
None
None
None
 0.92A 1bx4A-3fd0A:
undetectable		 1bx4A-3fd0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		5 ASN A  91
GLY A 342
GLY A 343
ALA A  89
LEU A 194
 None
 0.93A 1bx4A-3foaA:
undetectable		 1bx4A-3foaA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7k 3-METHYLITACONATE
ISOMERASE

(Eubacterium
barkeri) 		PF04303
(PrpF) 		5 GLN A  82
GLY A 305
GLY A  97
ASN A  98
PHE A  80
 None
 0.92A 1bx4A-3g7kA:
undetectable		 1bx4A-3g7kA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 ASP A  25
GLY A  50
GLY A  51
ASN A  55
ASP A 242
 RIB  A 305 (-2.8A)
RIB  A 305 ( 3.7A)
RIB  A 305 (-3.1A)
RIB  A 305 (-3.2A)
RIB  A 305 (-2.9A)
 0.29A 1bx4A-3go7A:
27.3		 1bx4A-3go7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		5 ASP A  33
GLY A  54
GLY A  55
ASN A  59
ASP A 275
 None
 0.39A 1bx4A-3hj6A:
28.3		 1bx4A-3hj6A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		5 LEU A 188
GLY A  54
GLY A  55
ASN A  59
ASP A 275
 None
 0.82A 1bx4A-3hj6A:
28.3		 1bx4A-3hj6A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae) 		PF00294
(PfkB) 		5 ASP A  12
GLY A  37
GLY A  38
ASN A  42
ASP A 232
 None
 0.84A 1bx4A-3i3yA:
25.8		 1bx4A-3i3yA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH

(Escherichia
coli) 		PF00294
(PfkB) 		5 ASP A  15
GLY A  41
GLY A  42
ASN A  46
ASP A 260
 None
 0.74A 1bx4A-3in1A:
30.5		 1bx4A-3in1A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH

(Escherichia
coli) 		PF00294
(PfkB) 		6 LEU A 148
GLY A  41
GLY A  42
ASN A  46
LEU A 121
ASP A 260
 None
 1.36A 1bx4A-3in1A:
30.5		 1bx4A-3in1A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 ASN U  91
GLY U 342
GLY U 343
ALA U  89
LEU U 194
 None
 0.93A 1bx4A-3j2nU:
undetectable		 1bx4A-3j2nU:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
monocytogenes) 		PF06838
(Met_gamma_lyase) 		5 ASN A 227
GLY A 231
GLY A 230
ALA A 286
LEU A 315
 LLP  A 226 ( 4.6A)
None
None
None
None
 0.92A 1bx4A-3jzlA:
undetectable		 1bx4A-3jzlA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		5 ASP A  12
LEU A 101
GLY A  26
GLY A  27
ASP A 237
 AMP  A 509 (-2.8A)
None
AMP  A 509 ( 3.8A)
AMP  A 509 (-3.4A)
AMP  A 509 ( 3.3A)
 1.01A 1bx4A-3kd6A:
28.3		 1bx4A-3kd6A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 415
GLY A 196
GLY A 195
ALA A 357
LEU A 413
 None
 0.91A 1bx4A-3kzuA:
undetectable		 1bx4A-3kzuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lki FRUCTOKINASE

(Xylella
fastidiosa) 		PF00294
(PfkB) 		6 ASN A 146
ASP A  24
GLY A  44
GLY A  45
ASN A  49
LEU A 181
 None
 1.11A 1bx4A-3lkiA:
26.2		 1bx4A-3lkiA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE

(Anopheles
gambiae) 		PF00294
(PfkB) 		11 ASN A  14
ASP A  18
LEU A  40
GLY A  63
GLY A  64
ASN A  68
CYH A 122
ALA A 135
LEU A 137
PHE A 168
ASP A 300
 B4P  A 349 ( 4.0A)
B4P  A 349 (-2.8A)
None
B4P  A 349 ( 3.8A)
B4P  A 349 (-3.5A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.4A)
None
B4P  A 349 (-3.4A)
B4P  A 349 (-3.4A)
 0.28A 1bx4A-3looA:
51.0		 1bx4A-3looA:
48.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		11 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
CYH A 123
ALA A 136
LEU A 138
PHE A 169
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
None
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.29A 1bx4A-3otxA:
49.7		 1bx4A-3otxA:
40.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 ASP A  19
GLY A  40
GLY A  41
ASN A  45
ASP A 264
 None
 0.35A 1bx4A-3pl2A:
30.8		 1bx4A-3pl2A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		6 ASN A   8
ASP A  12
GLY A  37
GLY A  38
CYH A  92
ASP A 251
 None
 0.95A 1bx4A-3q1yA:
25.6		 1bx4A-3q1yA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ASP A  14
GLY A  40
GLY A  41
ASN A  45
ASP A 254
 GOL  A 401 (-3.1A)
GOL  A 401 ( 3.7A)
GOL  A 401 (-3.8A)
GOL  A 401 (-3.9A)
None
 0.54A 1bx4A-3ry7A:
28.3		 1bx4A-3ry7A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdi PROTEASOME COMPONENT
PRE5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ASP E 142
LEU E 116
GLY E 140
ALA E 112
LEU E  92
 None
 0.98A 1bx4A-3sdiE:
undetectable		 1bx4A-3sdiE:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 ASP A 517
LEU A 487
GLY A 516
GLY A 439
ALA A 483
 None
 0.95A 1bx4A-3shwA:
undetectable		 1bx4A-3shwA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 223
GLY A 155
GLY A 154
ALA A 220
LEU A 214
 None
 1.04A 1bx4A-3tqpA:
undetectable		 1bx4A-3tqpA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 ASP A 517
LEU A 487
GLY A 516
GLY A 439
ALA A 483
 None
 0.97A 1bx4A-3tswA:
undetectable		 1bx4A-3tswA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 277
GLY A 314
GLY A 316
ALA A 273
LEU A 142
 None
 1.03A 1bx4A-3tz6A:
undetectable		 1bx4A-3tz6A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		8 ASN A  11
ASP A  15
LEU A  37
GLY A  58
GLY A  59
ASN A  63
LEU A 131
ASP A 278
 ADN  A 353 (-3.7A)
ADN  A 353 (-2.8A)
None
ADN  A 353 (-3.3A)
ADN  A 353 (-3.2A)
ADN  A 353 (-3.4A)
None
ADN  A 353 (-3.3A)
 0.55A 1bx4A-3uboA:
39.3		 1bx4A-3uboA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2

(Escherichia
coli) 		PF00294
(PfkB) 		5 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.78A 1bx4A-3uqeA:
25.3		 1bx4A-3uqeA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		9 ASN A  14
ASP A  18
LEU A  40
GLY A  63
GLY A  64
ASN A  68
LEU A 138
PHE A 169
ASP A 302
 ADN  A 401 ( 4.0A)
ADN  A 401 (-2.7A)
None
ADN  A 401 ( 3.8A)
ADN  A 401 (-3.7A)
ADN  A 401 (-3.7A)
ADN  A 401 (-4.9A)
ADN  A 401 (-3.7A)
ADN  A 401 (-2.9A)
 0.29A 1bx4A-3vasA:
49.7		 1bx4A-3vasA:
36.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		5 LEU A  83
GLY A 131
GLY A  89
ALA A 127
LEU A 122
 None
 1.01A 1bx4A-4cp8A:
undetectable		 1bx4A-4cp8A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		8 ASN A   9
ASP A  13
LEU A  35
GLY A  56
GLY A  57
ASN A  61
LEU A 129
ASP A 276
 ADN  A 500 (-3.8A)
ADN  A 500 (-2.7A)
None
ADN  A 500 (-3.5A)
ADN  A 500 (-3.7A)
ADN  A 500 (-3.5A)
None
ADN  A 500 (-2.8A)
 0.41A 1bx4A-4e3aA:
40.5		 1bx4A-4e3aA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		5 GLY A 214
GLY A 190
ALA A 187
LEU A 204
ASP A 347
 None
None
None
None
SO4  A 401 ( 4.6A)
 0.99A 1bx4A-4ehjA:
3.7		 1bx4A-4ehjA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 LEU A 172
GLY A  33
GLY A  34
ASN A  38
ASP A 270
 None
GOL  A 401 ( 4.1A)
GOL  A 401 (-3.7A)
GOL  A 401 (-4.4A)
GOL  A 401 (-3.0A)
 0.83A 1bx4A-4gm6A:
28.9		 1bx4A-4gm6A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 LEU A 116
GLY A  86
GLY A  85
ALA A 112
LEU A  57
 None
P6G  A 305 ( 3.7A)
P6G  A 305 (-4.9A)
None
None
 0.97A 1bx4A-4h16A:
5.7		 1bx4A-4h16A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg3 CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		5 LEU A  58
GLY A  69
CYH A  61
ALA A  60
LEU A  46
 None
 0.97A 1bx4A-4jg3A:
undetectable		 1bx4A-4jg3A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A 565
GLY A 520
GLY A 521
ALA A 546
LEU A 548
 None
 0.95A 1bx4A-4k3jA:
undetectable		 1bx4A-4k3jA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh1 L-IDITOL
2-DEHYDROGENASE

([Clostridium]
scindens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 162
GLY A 182
GLY A 183
ALA A 161
LEU A 191
 None
 0.98A 1bx4A-4oh1A:
4.4		 1bx4A-4oh1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		5 LEU A  71
GLY A 260
GLY A 259
ALA A  68
LEU A  67
 None
 1.00A 1bx4A-4p6bA:
undetectable		 1bx4A-4p6bA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		6 ASP A  12
GLN A 172
GLY A  47
GLY A  48
ASN A  52
ASP A 257
 HO4  A 401 (-2.4A)
HO4  A 401 (-3.7A)
HO4  A 401 (-3.5A)
HO4  A 401 (-3.5A)
HO4  A 401 (-3.8A)
HO4  A 401 (-3.3A)
 0.97A 1bx4A-4pvvA:
27.5		 1bx4A-4pvvA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		6 ASP A  12
GLY A  47
GLY A  48
ASN A  52
ALA A 100
ASP A 257
 HO4  A 401 (-2.4A)
HO4  A 401 (-3.5A)
HO4  A 401 (-3.5A)
HO4  A 401 (-3.8A)
None
HO4  A 401 (-3.3A)
 1.18A 1bx4A-4pvvA:
27.5		 1bx4A-4pvvA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		5 GLY A  93
GLY A  94
CYH A 135
ALA A 173
LEU A 175
 None
 0.99A 1bx4A-4qgsA:
undetectable		 1bx4A-4qgsA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		5 ASP A  11
GLY A  29
GLY A  30
ASN A  34
ASP A 249
 None
None
None
None
ANP  A 401 ( 4.3A)
 0.47A 1bx4A-4wjmA:
29.2		 1bx4A-4wjmA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		5 LEU A 162
GLY A  29
GLY A  30
ASN A  34
ASP A 249
 None
None
None
None
ANP  A 401 ( 4.3A)
 0.94A 1bx4A-4wjmA:
29.2		 1bx4A-4wjmA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		5 ASP A  13
GLY A  38
GLY A  39
ASN A  43
ASP A 252
 None
 0.52A 1bx4A-4x8fA:
30.0		 1bx4A-4x8fA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 5 LEU A 582
GLY A 303
ASN A 302
ALA A 515
LEU A 584
 None
 0.85A 1bx4A-5awpA:
undetectable		 1bx4A-5awpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 ASP A  27
GLY A  52
GLY A  53
ASN A  57
ASP A 269
 None
None
None
None
NA  A 403 ( 4.7A)
 0.51A 1bx4A-5c41A:
32.2		 1bx4A-5c41A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		5 LEU B 323
GLY B 475
ASN B 477
ALA B 319
LEU B  90
 None
 0.99A 1bx4A-5d9aB:
undetectable		 1bx4A-5d9aB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		5 GLN A 354
GLY A 280
ASN A 279
LEU A 527
PHE A 331
 None
 0.96A 1bx4A-5ejyA:
undetectable		 1bx4A-5ejyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		5 ASP A  30
GLY A  44
GLY A  45
ASN A  49
ASP A 266
 None
 0.43A 1bx4A-5ey7A:
30.6		 1bx4A-5ey7A:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgw EXTRACELLULAR
STREPTODORNASE D

(Streptococcus
pyogenes) 		PF01223
(Endonuclease_NS) 		5 GLY A 195
GLY A 196
ALA A 108
LEU A 189
PHE A 199
 None
 1.02A 1bx4A-5fgwA:
undetectable		 1bx4A-5fgwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN

(Lavandula
lanata) 		PF01255
(Prenyltransf) 		5 GLY A 198
GLY A 199
ASN A 257
ALA A 206
LEU A 233
 None
 0.97A 1bx4A-5hc8A:
undetectable		 1bx4A-5hc8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Solanum
habrochaites) 		PF01255
(Prenyltransf) 		5 GLY A 202
GLY A 203
ASN A 258
ALA A 210
LEU A 237
 None
 1.01A 1bx4A-5hxtA:
undetectable		 1bx4A-5hxtA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 ASP A  37
GLY A 114
GLY A 115
ALA A 204
ASP A 443
 GLC  A 503 (-2.7A)
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
GLC  A 503 (-2.6A)
 0.73A 1bx4A-5o0jA:
23.5		 1bx4A-5o0jA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 ASP A  37
LEU A  93
GLY A 114
GLY A 115
ALA A 204
 GLC  A 503 (-2.7A)
None
GLC  A 503 (-3.5A)
GLC  A 503 (-3.7A)
None
 0.59A 1bx4A-5o0jA:
23.5		 1bx4A-5o0jA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 ASP A  28
GLY A 106
GLY A 107
ALA A 201
ASP A 442
 GLC  A 501 (-2.7A)
GLC  A 501 (-3.2A)
GLC  A 501 (-3.7A)
None
GLC  A 501 ( 2.6A)
 0.58A 1bx4A-5od2A:
4.3		 1bx4A-5od2A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli) 		no annotation 5 ASP A 253
GLY A  20
CYH A  90
ALA A  89
LEU A 175
 None
 1.03A 1bx4A-5ya1A:
undetectable		 1bx4A-5ya1A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 LEU A  19
GLY A  98
GLY A  97
ALA A 146
LEU A  95
 None
NDP  A 502 (-2.6A)
NDP  A 502 (-3.1A)
None
None
 1.02A 1bx4A-5yvsA:
3.0		 1bx4A-5yvsA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4

(Xenopus
tropicalis) 		no annotation 5 LEU A 191
GLY A 200
GLY A 201
ALA A 194
LEU A 195
 None
 0.97A 1bx4A-6bbjA:
undetectable		 1bx4A-6bbjA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw5 RIBOKINASE

(Cryptococcus
neoformans) 		no annotation 5 ASP A  16
GLY A  41
GLY A  42
ASN A  46
ASP A 273
 GOL  A 400 (-2.8A)
GOL  A 400 (-3.5A)
GOL  A 400 (-3.3A)
GOL  A 400 (-3.3A)
None
 0.31A 1bx4A-6cw5A:
31.2		 1bx4A-6cw5A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atj PEROXIDASE C1A

(Armoracia
rusticana) 		PF00141
(peroxidase) 		3 LEU A 166
SER A 161
ASN A 158
 HEM  A 350 (-4.0A)
None
None
 0.68A 1bx4A-1atjA:
undetectable		 1bx4A-1atjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		3 LEU A 342
SER A 140
ASN A  63
 None
 0.70A 1bx4A-1c4oA:
0.2		 1bx4A-1c4oA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		3 LEU A 114
SER A  76
ASN A  96
 None
 0.56A 1bx4A-1dc1A:
undetectable		 1bx4A-1dc1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwe PROTEIN (DNAB
HELICASE)

(Escherichia
coli) 		PF00772
(DnaB) 		3 LEU A  42
SER A  35
ASN A 117
 None
 0.77A 1bx4A-1jweA:
undetectable		 1bx4A-1jweA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1le8 MATING-TYPE PROTEIN
ALPHA-2

(Saccharomyces
cerevisiae) 		PF00046
(Homeobox) 		3 LEU B 162
SER B 172
ASN B 178
 None
 0.79A 1bx4A-1le8B:
undetectable		 1bx4A-1le8B:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 LEU A 247
SER A 242
ASN A 240
 None
None
HEM  A 430 (-3.9A)
 0.82A 1bx4A-1lgfA:
undetectable		 1bx4A-1lgfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 LEU A 117
SER A  13
ASN A  15
 None
 0.78A 1bx4A-1lpjA:
undetectable		 1bx4A-1lpjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		3 LEU A 316
SER A 311
ASN A 262
 None
 0.79A 1bx4A-1sb8A:
5.2		 1bx4A-1sb8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svv THREONINE ALDOLASE

(Leishmania
major) 		PF01212
(Beta_elim_lyase) 		3 LEU A 191
SER A 193
ASN A 298
 None
 0.77A 1bx4A-1svvA:
3.7		 1bx4A-1svvA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 LEU A 233
SER A 236
ASN A 288
 None
 0.59A 1bx4A-1u3dA:
2.9		 1bx4A-1u3dA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		3 LEU A 139
SER A 148
ASN A 542
 None
 0.82A 1bx4A-1w18A:
undetectable		 1bx4A-1w18A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wj5 HYPOTHETICAL PROTEIN
(RIKEN CDNA
0610009H20)

(Mus musculus) 		PF09170
(STN1_2) 		3 LEU A  51
SER A  22
ASN A  82
 None
 0.75A 1bx4A-1wj5A:
undetectable		 1bx4A-1wj5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvt HYPOTHETICAL PROTEIN
ST2180

(Sulfurisphaera
tokodaii) 		PF01923
(Cob_adeno_trans) 		3 LEU A  46
SER A 110
ASN A 163
 None
 0.78A 1bx4A-1wvtA:
undetectable		 1bx4A-1wvtA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxg ENTEROTOXIN

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 LEU A  50
SER A  47
ASN A  68
 None
 0.66A 1bx4A-1xxgA:
undetectable		 1bx4A-1xxgA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		3 LEU A 109
SER A 104
ASN A 143
 None
 0.72A 1bx4A-1yzfA:
3.0		 1bx4A-1yzfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON

(Salmonella
enterica) 		PF01569
(PAP2) 		3 LEU A 169
SER A  88
ASN A 238
 None
 0.82A 1bx4A-2akcA:
undetectable		 1bx4A-2akcA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		3 LEU A  14
SER A 713
ASN A 715
 None
 0.77A 1bx4A-2b0tA:
undetectable		 1bx4A-2b0tA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 LEU A 101
SER A  20
ASN A  71
 None
 0.68A 1bx4A-2f3oA:
undetectable		 1bx4A-2f3oA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 LEU A 419
SER A 287
ASN A 328
 None
 0.70A 1bx4A-2f7lA:
undetectable		 1bx4A-2f7lA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 LEU A 511
SER A 165
ASN A 162
 None
 0.80A 1bx4A-2fgeA:
undetectable		 1bx4A-2fgeA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		3 LEU A 168
SER A 161
ASN A 183
 None
 0.73A 1bx4A-2jf4A:
undetectable		 1bx4A-2jf4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqn CRK-LIKE PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07653
(SH3_2) 		3 LEU A  28
SER A  59
ASN A  55
 None
 0.77A 1bx4A-2lqnA:
undetectable		 1bx4A-2lqnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA

(Aspergillus
nidulans) 		PF01185
(Hydrophobin) 		3 LEU A  50
SER A  45
ASN A  43
 None
 0.81A 1bx4A-2lshA:
undetectable		 1bx4A-2lshA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwy BACTERIAL
INTEIN-LIKE DOMAIN

(Ruminiclostridium
thermocellum) 		PF07591
(PT-HINT) 		3 LEU A  90
SER A  92
ASN A 129
 None
 0.84A 1bx4A-2lwyA:
undetectable		 1bx4A-2lwyA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		3 LEU A 226
SER A 222
ASN A  30
 None
 0.75A 1bx4A-2ok8A:
4.4		 1bx4A-2ok8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9w MAL S 1 ALLERGENIC
PROTEIN

(Malassezia
sympodialis) 		no annotation 3 LEU A 230
SER A 290
ASN A 287
 None
 0.67A 1bx4A-2p9wA:
undetectable		 1bx4A-2p9wA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2taa TAKA-AMYLASE A

(Aspergillus
oryzae) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 LEU A 114
SER A 105
ASN A 197
 None
 0.84A 1bx4A-2taaA:
undetectable		 1bx4A-2taaA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhe ACETYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep) 		3 LEU A 153
SER A 169
ASN A 150
 None
 0.82A 1bx4A-2vheA:
undetectable		 1bx4A-2vheA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfo GLYCOPROTEIN 1

(Machupo
mammarenavirus) 		PF00798
(Arena_glycoprot) 		3 LEU A 132
SER A 141
ASN A 137
 None
None
NAG  A1243 (-1.8A)
 0.79A 1bx4A-2wfoA:
undetectable		 1bx4A-2wfoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		3 LEU A 222
SER A 220
ASN A  79
 None
PLP  A1211 (-3.4A)
None
 0.83A 1bx4A-2x3lA:
3.0		 1bx4A-2x3lA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA

(Homo sapiens) 		PF01504
(PIP5K) 		3 LEU A 122
SER A 137
ASN A 198
 None
 0.84A 1bx4A-2ybxA:
undetectable		 1bx4A-2ybxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 LEU A 321
SER A 295
ASN A 291
 None
None
NAG  A2911 (-1.9A)
 0.76A 1bx4A-3ciyA:
undetectable		 1bx4A-3ciyA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 LEU A 151
SER A 230
ASN A 176
 None
 0.73A 1bx4A-3cttA:
undetectable		 1bx4A-3cttA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LEU A  27
SER A  22
ASN A 189
 None
 0.77A 1bx4A-3e7wA:
undetectable		 1bx4A-3e7wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnk CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		3 LEU A  98
SER A  68
ASN A  66
 None
 0.57A 1bx4A-3fnkA:
undetectable		 1bx4A-3fnkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzy RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		3 LEU A3492
SER A3494
ASN A3438
 None
 0.76A 1bx4A-3fzyA:
undetectable		 1bx4A-3fzyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcd RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		3 LEU A  64
SER A  66
ASN A  10
 None
 0.77A 1bx4A-3gcdA:
undetectable		 1bx4A-3gcdA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk3 ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		3 LEU A 222
SER A 183
ASN A 138
 None
 0.66A 1bx4A-3gk3A:
6.6		 1bx4A-3gk3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 LEU A 486
SER A 509
ASN A 243
 None
 0.78A 1bx4A-3hjrA:
undetectable		 1bx4A-3hjrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F

(Bacteroides
fragilis) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		3 LEU A 278
SER A 302
ASN A 310
 None
 0.83A 1bx4A-3ks7A:
undetectable		 1bx4A-3ks7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		3 LEU A 261
SER A 231
ASN A 229
 None
 0.70A 1bx4A-3l8qA:
undetectable		 1bx4A-3l8qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 LEU A 297
SER A 295
ASN A 383
 None
 0.71A 1bx4A-3lp8A:
undetectable		 1bx4A-3lp8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2p UDP-N-ACETYLGLUCOSAM
INE 4-EPIMERASE

(Bacillus cereus) 		PF01370
(Epimerase) 		3 LEU A 271
SER A 266
ASN A 120
 None
 0.71A 1bx4A-3m2pA:
5.7		 1bx4A-3m2pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2p UDP-N-ACETYLGLUCOSAM
INE 4-EPIMERASE

(Bacillus cereus) 		PF01370
(Epimerase) 		3 LEU A 271
SER A 266
ASN A 221
 None
 0.74A 1bx4A-3m2pA:
5.7		 1bx4A-3m2pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 LEU A 517
SER A 579
ASN B 254
 None
 0.76A 1bx4A-3mcaA:
undetectable		 1bx4A-3mcaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		3 LEU A 463
SER A 459
ASN A 455
 None
 0.83A 1bx4A-3mdyA:
undetectable		 1bx4A-3mdyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obf PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Paenarthrobacter
aurescens) 		PF01614
(IclR) 		3 LEU A 193
SER A 188
ASN A 238
 None
 0.65A 1bx4A-3obfA:
undetectable		 1bx4A-3obfA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 3 LEU A  50
SER A  47
ASN A  64
 None
 0.79A 1bx4A-3p4gA:
undetectable		 1bx4A-3p4gA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacterium
tuberculosis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 LEU A  52
SER A  90
ASN A  48
 None
 0.83A 1bx4A-3pygA:
undetectable		 1bx4A-3pygA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		3 LEU A 503
SER A 433
ASN A 176
 None
 0.84A 1bx4A-3qkiA:
undetectable		 1bx4A-3qkiA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtd PMBA PROTEIN

(Pseudomonas
aeruginosa) 		PF01523
(PmbA_TldD) 		3 LEU A 338
SER A 332
ASN A 343
 None
 0.76A 1bx4A-3qtdA:
undetectable		 1bx4A-3qtdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		3 LEU A 427
SER A 330
ASN A 334
 None
 0.80A 1bx4A-3sggA:
undetectable		 1bx4A-3sggA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1b TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio cholerae) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		3 LEU A 164
SER A 258
ASN A 201
 None
 0.75A 1bx4A-3t1bA:
undetectable		 1bx4A-3t1bA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN) 		3 LEU A 203
SER A 201
ASN A  64
 None
 0.82A 1bx4A-3tw8A:
undetectable		 1bx4A-3tw8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 LEU A 710
SER A 700
ASN A 733
 None
None
AP2  A 806 (-4.9A)
 0.50A 1bx4A-3vthA:
undetectable		 1bx4A-3vthA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzg ZYMOGEN GRANULE
MEMBRANE PROTEIN 16

(Homo sapiens) 		PF01419
(Jacalin) 		3 LEU A 133
SER A  23
ASN A 136
 None
 0.58A 1bx4A-3vzgA:
undetectable		 1bx4A-3vzgA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egt MAJOR CAPSID PROTEIN
VP60

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		3 LEU A 547
SER A 465
ASN A 253
 None
 0.71A 1bx4A-4egtA:
undetectable		 1bx4A-4egtA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fb5 PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 LEU A 239
SER A 244
ASN A 154
 None
 0.84A 1bx4A-4fb5A:
undetectable		 1bx4A-4fb5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gba DCN1-LIKE PROTEIN 3

(Homo sapiens) 		PF03556
(Cullin_binding) 		3 LEU A 191
SER A 239
ASN A 244
 None
 0.78A 1bx4A-4gbaA:
undetectable		 1bx4A-4gbaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00652
(Ricin_B_lectin) 		3 LEU C 105
SER C 107
ASN C 115
 None
 0.79A 1bx4A-4hr6C:
undetectable		 1bx4A-4hr6C:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 LEU A 573
SER A 569
ASN A 545
 None
 0.84A 1bx4A-4j0mA:
undetectable		 1bx4A-4j0mA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE

(Cupriavidus
metallidurans) 		PF00378
(ECH_1) 		3 LEU A  52
SER A  54
ASN A  18
 None
 0.62A 1bx4A-4jcsA:
undetectable		 1bx4A-4jcsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnq THIOREDOXIN
REDUCTASE

(Brucella
melitensis) 		PF07992
(Pyr_redox_2) 		3 LEU A 192
SER A 198
ASN A 196
 None
 0.80A 1bx4A-4jnqA:
undetectable		 1bx4A-4jnqA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
drancourtii) 		no annotation 3 LEU A 576
SER A 542
ASN A 569
 ACY  A 701 ( 4.5A)
None
None
 0.80A 1bx4A-4jvsA:
undetectable		 1bx4A-4jvsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6c ACETOACETYL-COA
REDUCTASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		3 LEU A 221
SER A 182
ASN A 137
 None
 0.72A 1bx4A-4k6cA:
3.4		 1bx4A-4k6cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Acidaminococcus
fermentans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 LEU A  24
SER A  77
ASN A 355
 None
 0.74A 1bx4A-4l1fA:
undetectable		 1bx4A-4l1fA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 LEU A  82
SER A  78
ASN A 175
 None
NAI  A 401 (-3.1A)
None
 0.78A 1bx4A-4n54A:
4.8		 1bx4A-4n54A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pph CONGLUTIN GAMMA

(Lupinus
angustifolius) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 LEU A  27
SER A  24
ASN A 158
 None
 0.76A 1bx4A-4pphA:
undetectable		 1bx4A-4pphA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 LEU A 463
SER A 482
ASN A 475
 None
 0.77A 1bx4A-4q6rA:
undetectable		 1bx4A-4q6rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 LEU A 799
SER A 801
ASN A1801
 None
 0.82A 1bx4A-4r04A:
undetectable		 1bx4A-4r04A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rav SINGLE-CHAIN FV, VL

(Homo sapiens) 		PF07686
(V-set) 		3 LEU B 176
SER B 192
ASN B 189
 None
 0.69A 1bx4A-4ravB:
undetectable		 1bx4A-4ravB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 LEU A  89
SER A  87
ASN A  85
 None
None
DDZ  A  64 ( 4.0A)
 0.74A 1bx4A-4uphA:
undetectable		 1bx4A-4uphA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wi0 CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		3 LEU A  91
SER A  61
ASN A  59
 None
 0.63A 1bx4A-4wi0A:
undetectable		 1bx4A-4wi0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE

(Jonesia
denitrificans) 		PF00697
(PRAI) 		3 LEU A 106
SER A 109
ASN A 111
 None
 0.79A 1bx4A-4wuiA:
undetectable		 1bx4A-4wuiA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1

(Capnocytophaga
gingivalis) 		no annotation 3 LEU C  15
SER C 160
ASN C 166
 None
 0.70A 1bx4A-4xruC:
3.5		 1bx4A-4xruC:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxf MUPS

(Pseudomonas
fluorescens) 		PF13561
(adh_short_C2) 		3 LEU A 233
SER A 195
ASN A 150
 None
 0.53A 1bx4A-4yxfA:
3.3		 1bx4A-4yxfA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8t AVRRXO1-ORF1

(Xanthomonas
oryzae) 		no annotation 3 LEU A 131
SER A 218
ASN A 191
 None
 0.78A 1bx4A-4z8tA:
undetectable		 1bx4A-4z8tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6s ENDOLYSIN

(Clostridium
phage phiCTP1) 		PF01183
(Glyco_hydro_25) 		3 LEU A  10
SER A 173
ASN A  13
 None
 0.77A 1bx4A-5a6sA:
undetectable		 1bx4A-5a6sA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a99 POLYHEDRIN

(Operophtera
brumata
cypovirus 19) 		no annotation 3 LEU A  37
SER A 186
ASN A  62
 None
 0.83A 1bx4A-5a99A:
undetectable		 1bx4A-5a99A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		3 LEU A 859
SER A 811
ASN A 871
 None
 0.82A 1bx4A-5j44A:
undetectable		 1bx4A-5j44A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ke1 OUTER MEMBRANE
PROTEIN ICSA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF03212
(Pertactin)
PF12951
(PATR) 		3 LEU A 535
SER A 530
ASN A 548
 None
 0.77A 1bx4A-5ke1A:
undetectable		 1bx4A-5ke1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		3 LEU A  93
SER A  89
ASN A  87
 None
 0.58A 1bx4A-5kzsA:
undetectable		 1bx4A-5kzsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li4 TAIL SHEATH PROTEIN

(Staphylococcus
phage 812) 		no annotation 3 LEU A  62
SER A  57
ASN A  81
 None
 0.84A 1bx4A-5li4A:
undetectable		 1bx4A-5li4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE

(Acaryochloris
marina) 		no annotation 3 LEU A 268
SER A 189
ASN A 556
 None
 0.77A 1bx4A-5lpcA:
undetectable		 1bx4A-5lpcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		3 LEU A 101
SER A  97
ASN A 138
 None
 0.76A 1bx4A-5m23A:
undetectable		 1bx4A-5m23A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 3 LEU A 183
SER A 175
ASN A  72
 None
SNN  A 176 ( 3.4A)
CIT  A 502 (-3.8A)
 0.82A 1bx4A-5nijA:
3.0		 1bx4A-5nijA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 3 LEU A 183
SER A 175
ASN A  72
 None
SNN  A 176 ( 3.2A)
None
 0.80A 1bx4A-5obtA:
3.1		 1bx4A-5obtA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 3 LEU A 661
SER A 624
ASN A 620
 None
 0.74A 1bx4A-5oglA:
undetectable		 1bx4A-5oglA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3a INTEGRASE

(Visna-maedi
virus) 		PF00665
(rve) 		3 LEU A 167
SER A 176
ASN A 172
 MES  A 304 ( 4.4A)
ACT  A 301 (-3.0A)
ACT  A 301 (-4.0A)
 0.74A 1bx4A-5t3aA:
undetectable		 1bx4A-5t3aA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE

(Campylobacter
jejuni) 		PF05523
(FdtA) 		3 LEU A 106
SER A  64
ASN A  99
 None
 0.81A 1bx4A-5tpvA:
undetectable		 1bx4A-5tpvA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tru CYTOTOXIC
T-LYMPHOCYTE PROTEIN
4

(Homo sapiens) 		PF07686
(V-set) 		3 LEU c  79
SER c  72
ASN c  75
 None
 0.81A 1bx4A-5truc:
undetectable		 1bx4A-5truc:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 318
SER A 308
ASN A 133
 None
 0.69A 1bx4A-5xd7A:
undetectable		 1bx4A-5xd7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 3 LEU A 279
SER A 237
ASN A 242
 None
 0.77A 1bx4A-5y8pA:
undetectable		 1bx4A-5y8pA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 3 LEU A 365
SER A 355
ASN A 359
 None
 0.83A 1bx4A-5zqjA:
undetectable		 1bx4A-5zqjA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azt ASPARAGINYL
ENDOPEPTIDASE 1

(Helianthus
annuus) 		no annotation 3 LEU A 184
SER A 176
ASN A  73
 None
SNN  A 177 ( 3.5A)
None
 0.78A 1bx4A-6aztA:
2.9		 1bx4A-6aztA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 3 LEU A 389
SER A 416
ASN A 422
 None
 0.67A 1bx4A-6b5cA:
undetectable		 1bx4A-6b5cA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b TOXIN B

(Clostridioides
difficile) 		no annotation 3 LEU A1641
SER A1677
ASN A1734
 None
 0.72A 1bx4A-6c0bA:
undetectable		 1bx4A-6c0bA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0m HEMAGGLUTININ-NEURAM
INIDASE

(Human
respirovirus 3) 		no annotation 3 LEU A 484
SER A 510
ASN A 517
 None
 0.82A 1bx4A-6c0mA:
undetectable		 1bx4A-6c0mA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 3 LEU A 471
SER A 763
ASN A 767
 None
 0.73A 1bx4A-6d95A:
undetectable		 1bx4A-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A  48
SER A 504
ASN A 507
 None
 0.76A 1bx4A-6eojA:
undetectable		 1bx4A-6eojA:
13.71