SIMILAR PATTERNS OF AMINO ACIDS FOR 1BSX_A_T3A1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.83A 1bsxA-1ej6B:
1.3		 1bsxA-1ej6B:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  47
ILE A  41
ALA A  68
LEU A 112
ILE A 109
 None
 1.17A 1bsxA-1h74A:
0.0		 1bsxA-1h74A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iz1 LYSR-TYPE REGULATORY
PROTEIN

(Cupriavidus
necator) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 ILE A 219
ILE A 207
LEU A 191
LEU A 183
ILE A 259
 None
 1.06A 1bsxA-1iz1A:
undetectable		 1bsxA-1iz1A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME ALPHA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ILE A  40
ILE A  38
ALA A 233
LEU A 199
ILE A 233
 None
 1.15A 1bsxA-1j2qA:
0.0		 1bsxA-1j2qA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 ILE A 100
ILE A  52
MET A  64
ALA A 301
LEU A  99
 None
 1.12A 1bsxA-1jqgA:
0.0		 1bsxA-1jqgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6r HYPOTHETICAL PROTEIN
TA0175

(Thermoplasma
acidophilum) 		PF08282
(Hydrolase_3) 		5 ILE A 214
ILE A 217
ALA A 194
ILE A 198
PHE A 221
 None
 1.15A 1bsxA-1l6rA:
0.0		 1bsxA-1l6rA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 5 MET T  52
ALA T  26
LEU T  22
LEU T  37
ILE T  35
 None
 1.05A 1bsxA-1lthT:
0.0		 1bsxA-1lthT:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 221
ILE A 222
ARG A 228
MET A 256
MET A 259
ALA A 263
LEU A 276
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.66A 1bsxA-1navA:
37.4		 1bsxA-1navA:
83.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 222
MET A 259
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.44A 1bsxA-1navA:
37.4		 1bsxA-1navA:
83.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		5 ILE A  20
ARG A 179
LEU A  14
LEU A  85
ILE A  87
 None
SO4  A 409 (-4.1A)
None
None
OCS  A  88 ( 4.0A)
 1.04A 1bsxA-1o1yA:
0.0		 1bsxA-1o1yA:
23.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 275
ILE A 276
ARG A 282
MET A 310
MET A 313
ALA A 317
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.60A 1bsxA-1q4xA:
36.7		 1bsxA-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxm DNA POLYMERASE
SLIDING CLAMP

(Archaeoglobus
fulgidus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ILE A  67
ILE A  27
MET A  71
LEU A  97
LEU A  11
 None
 1.03A 1bsxA-1rxmA:
undetectable		 1bsxA-1rxmA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR

(Caenorhabditis
elegans) 		PF00452
(Bcl-2)
PF02180
(BH4)
PF11430
(EGL-1) 		5 ILE A 172
ARG A 219
MET A 231
MET C  69
ALA C  67
 None
 1.08A 1bsxA-1ty4A:
undetectable		 1bsxA-1ty4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2f CELL DIVISION
PROTEIN ZIPA

(Escherichia
coli) 		PF04354
(ZipA_C) 		5 ILE A  12
ILE A  11
MET A 101
ALA A 105
LEU A 129
 WAI  A 300 ( 4.9A)
None
None
None
None
 1.11A 1bsxA-1y2fA:
undetectable		 1bsxA-1y2fA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		5 ILE A 415
ILE A 414
ALA A 359
LEU A 366
ILE A 355
 None
 1.10A 1bsxA-1yp4A:
undetectable		 1bsxA-1yp4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A  45
ILE A  56
ALA A 111
LEU A  38
ILE A 107
 None
 1.14A 1bsxA-1ysjA:
undetectable		 1bsxA-1ysjA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmb ACETYLXYLAN ESTERASE
RELATED ENZYME

(Clostridium
acetobutylicum) 		PF03629
(SASA) 		5 ILE A 154
ILE A 153
LEU A 115
LEU A 111
ILE A  76
 None
 1.02A 1bsxA-1zmbA:
undetectable		 1bsxA-1zmbA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 ILE D 139
LEU D 129
LEU D  99
ILE D 108
PHE D 161
 None
 1.03A 1bsxA-2g9hD:
undetectable		 1bsxA-2g9hD:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbz OLIGORIBONUCLEASE

(Xanthomonas
campestris) 		PF00929
(RNase_T) 		5 ILE A  29
ILE A  51
ARG A  77
LEU A 119
ILE A  14
 None
 0.88A 1bsxA-2gbzA:
undetectable		 1bsxA-2gbzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hms YUAA PROTEIN

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		5 ILE A  12
ILE A  78
LEU A 113
ILE A 116
HIS A 109
 None
NAI  A 601 (-3.9A)
None
None
None
 1.11A 1bsxA-2hmsA:
undetectable		 1bsxA-2hmsA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i59 REGULATOR OF
G-PROTEIN SIGNALING
10

(Homo sapiens) 		PF00615
(RGS) 		5 ILE A  66
MET A  99
LEU A  87
ILE A  91
PHE A  43
 None
 1.18A 1bsxA-2i59A:
undetectable		 1bsxA-2i59A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		5 ILE A1209
ILE A1205
ALA A1196
ILE A1171
PHE A1234
 None
 1.15A 1bsxA-2ix8A:
undetectable		 1bsxA-2ix8A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00069
(Pkinase)
PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		5 ILE B 254
ALA A  48
LEU A  37
ILE A  35
HIS A  71
 None
 1.15A 1bsxA-2jgzB:
2.7		 1bsxA-2jgzB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 ILE A 173
ARG A 202
ALA A 165
LEU A 169
ILE A 341
 None
None
CL  A1369 (-4.0A)
None
None
 1.01A 1bsxA-2ji4A:
undetectable		 1bsxA-2ji4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkt PDZ AND LIM DOMAIN
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  30
ILE A  50
ARG A  83
ALA A  42
LEU A  77
 None
 1.08A 1bsxA-2pktA:
undetectable		 1bsxA-2pktA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		5 ILE A 349
ILE A 367
MET A  65
LEU A 180
ILE A  72
 None
 1.07A 1bsxA-2pyxA:
undetectable		 1bsxA-2pyxA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		5 ILE A 197
ILE A 198
MET A 169
ALA A 173
LEU A 388
 None
None
None
None
PE5  A 407 (-3.6A)
 1.13A 1bsxA-2r09A:
undetectable		 1bsxA-2r09A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		5 ILE A 197
ILE A 198
MET A 169
ALA A 173
PHE A 262
 None
 0.99A 1bsxA-2r09A:
undetectable		 1bsxA-2r09A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ILE A  96
ILE A  54
ALA A  68
LEU A  85
LEU A  42
 None
 1.05A 1bsxA-2vwkA:
undetectable		 1bsxA-2vwkA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcu PROTEIN FUCU HOMOLOG

(Mus musculus) 		PF05025
(RbsD_FucU) 		5 ILE A  55
ILE A 141
ARG A  97
ALA A  61
LEU A  58
 None
 1.15A 1bsxA-2wcuA:
undetectable		 1bsxA-2wcuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		5 ILE B 478
ALA B 468
LEU B 588
ILE B 599
PHE B 577
 None
 1.09A 1bsxA-2xfgB:
undetectable		 1bsxA-2xfgB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE

(Plesiocystis
pacifica) 		PF00561
(Abhydrolase_1) 		5 ILE A 127
MET A 257
LEU A 150
LEU A 143
ILE A 264
 None
 1.13A 1bsxA-2xt0A:
undetectable		 1bsxA-2xt0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aay PUTATIVE THIOSULFATE
SULFURTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		5 ALA A 221
LEU A 217
LEU A 246
ILE A 161
HIS A 252
 None
None
None
None
SO4  A 600 (-4.0A)
 1.17A 1bsxA-3aayA:
undetectable		 1bsxA-3aayA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dee PUTATIVE REGULATORY
PROTEIN

(Neisseria
gonorrhoeae) 		PF09836
(DUF2063) 		5 ILE A 226
ILE A 225
MET A 184
LEU A 159
ILE A 140
 None
 1.01A 1bsxA-3deeA:
undetectable		 1bsxA-3deeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF13377
(Peripla_BP_3) 		5 ALA A 146
LEU A 121
LEU A 130
ILE A 150
HIS A 135
 None
 1.13A 1bsxA-3e3mA:
undetectable		 1bsxA-3e3mA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g23 LD-CARBOXYPEPTIDASE
A

(Novosphingobium
aromaticivorans) 		PF02016
(Peptidase_S66) 		5 ILE A   7
ALA A 124
LEU A 101
LEU A 143
PHE A  37
 None
 1.03A 1bsxA-3g23A:
undetectable		 1bsxA-3g23A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		5 ILE A 215
ILE A 302
LEU A 214
LEU A 277
ILE A 253
 PG4  A   2 (-3.7A)
None
None
None
None
 1.15A 1bsxA-3h41A:
undetectable		 1bsxA-3h41A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE B1108
ILE B1109
ALA A 299
LEU B1100
PHE A  11
 None
 1.16A 1bsxA-3hkzB:
undetectable		 1bsxA-3hkzB:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A 299
MET A 264
LEU A 255
LEU A 274
ILE A 245
 None
 1.10A 1bsxA-3iplA:
undetectable		 1bsxA-3iplA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ILE A 257
ILE A 415
ALA A 434
LEU A 441
ILE A 438
 None
 1.12A 1bsxA-3jysA:
undetectable		 1bsxA-3jysA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		5 ILE A 307
LEU A 303
LEU A 281
ILE A 294
HIS A 226
 None
 1.07A 1bsxA-3n11A:
undetectable		 1bsxA-3n11A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		5 ILE A 206
ILE A 159
ALA A 187
LEU A 146
ILE A 150
 None
 1.09A 1bsxA-3op7A:
undetectable		 1bsxA-3op7A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		5 ILE A 247
ALA A 231
LEU A 235
LEU A 266
ILE A 185
 None
 1.15A 1bsxA-3pt1A:
undetectable		 1bsxA-3pt1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4

(Homo sapiens) 		PF04130
(Spc97_Spc98) 		5 ILE A 356
ILE A 357
LEU A 543
ILE A 547
HIS A 560
 None
 1.09A 1bsxA-3ripA:
undetectable		 1bsxA-3ripA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		6 ILE A 231
ALA A 292
LEU A 227
LEU A 287
ILE A 335
HIS A  61
 None
 1.38A 1bsxA-3sggA:
undetectable		 1bsxA-3sggA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 MET A 184
ALA A 188
LEU A 234
ILE A 228
PHE A 203
 None
 1.15A 1bsxA-3sszA:
undetectable		 1bsxA-3sszA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ILE A 264
ILE A 205
ALA A 290
LEU A 457
ILE A 456
 None
 1.11A 1bsxA-3ue3A:
undetectable		 1bsxA-3ue3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		5 ILE A 447
ILE A 448
ALA A 456
LEU A 468
ILE A 490
 None
None
AU  A1749 ( 3.9A)
None
AU  A1749 (-4.6A)
 1.15A 1bsxA-4b8bA:
undetectable		 1bsxA-4b8bA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		5 ILE A 203
ILE A 305
LEU A 376
ILE A 373
PHE A 303
 None
 1.08A 1bsxA-4dwsA:
undetectable		 1bsxA-4dwsA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 306
ALA A 212
LEU A 126
LEU A 265
ILE A 216
 None
 1.14A 1bsxA-4e3cA:
undetectable		 1bsxA-4e3cA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE

(Staphylococcus
aureus) 		PF00494
(SQS_PSY) 		5 ILE A 167
ILE A 249
MET A 227
LEU A 164
ILE A 241
 None
None
None
3RX  A 301 ( 4.5A)
None
 1.12A 1bsxA-4ea1A:
undetectable		 1bsxA-4ea1A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gic HISTIDINOL
DEHYDROGENASE

(Methylococcus
capsulatus) 		PF00815
(Histidinol_dh) 		5 ILE A 274
ILE A 276
ALA A 351
LEU A 336
ILE A 354
 None
 1.11A 1bsxA-4gicA:
undetectable		 1bsxA-4gicA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1

(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		no annotation 5 ILE B 200
ALA B 290
LEU B 287
LEU B 238
ILE B 240
 None
 1.13A 1bsxA-4h2xB:
undetectable		 1bsxA-4h2xB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ILE A 870
ALA A 767
LEU A 689
ILE A 764
PHE A 878
 None
 1.14A 1bsxA-4htzA:
1.9		 1bsxA-4htzA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzi ABC TRANSPORTER
ATP-BINDING PROTEIN

(Leptospira
interrogans) 		PF00005
(ABC_tran) 		5 ILE A 202
ILE A 168
LEU A  48
LEU A   7
ILE A  63
 None
 1.08A 1bsxA-4hziA:
undetectable		 1bsxA-4hziA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		5 ILE A 784
ILE A 831
LEU A 876
ILE A 944
PHE A 832
 None
 1.15A 1bsxA-4ifqA:
undetectable		 1bsxA-4ifqA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		5 ILE A 311
ILE A 313
LEU A 302
ILE A 247
PHE A 318
 None
None
GOL  A 502 (-4.6A)
GOL  A 502 ( 4.4A)
None
 1.18A 1bsxA-4ijaA:
undetectable		 1bsxA-4ijaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		5 ILE A 328
ILE A 295
LEU A 302
ILE A 200
PHE A 251
 None
None
GOL  A 502 (-4.6A)
None
None
 1.16A 1bsxA-4ijaA:
undetectable		 1bsxA-4ijaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itk APOFERREDOXIN

(Chlamydomonas
reinhardtii) 		PF00111
(Fer2) 		5 ARG A  39
MET A  32
ALA A  26
LEU A  23
ILE A  15
 None
 1.06A 1bsxA-4itkA:
undetectable		 1bsxA-4itkA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 ILE A  12
ILE A  78
LEU A 113
ILE A 116
HIS A 109
 None
ADP  A 601 (-3.8A)
None
None
None
 1.12A 1bsxA-4j91A:
undetectable		 1bsxA-4j91A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 ARG A 566
ALA A1024
LEU A1007
LEU A1016
ILE A1034
 None
 1.14A 1bsxA-4jx6A:
undetectable		 1bsxA-4jx6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis) 		PF00696
(AA_kinase) 		5 ILE A  34
ALA A 301
LEU A 298
LEU A  51
ILE A   9
 None
 1.09A 1bsxA-4jz7A:
undetectable		 1bsxA-4jz7A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kny KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 ILE A  49
ARG A  68
ALA A 115
LEU A  48
LEU A 108
 None
 1.12A 1bsxA-4knyA:
undetectable		 1bsxA-4knyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 1.08A 1bsxA-4m38A:
undetectable		 1bsxA-4m38A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18)
PF16403
(DUF5011) 		5 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
 1.13A 1bsxA-4mb5A:
undetectable		 1bsxA-4mb5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me3 DNA REPLICATION
LICENSING FACTOR MCM
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF17207
(MCM_OB) 		5 ILE A 256
ILE A  94
ALA A  69
ILE A  11
PHE A  45
 None
 1.13A 1bsxA-4me3A:
undetectable		 1bsxA-4me3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oci CALMODULIN, PUTATIVE

(Entamoeba
histolytica) 		PF00036
(EF-hand_1)
PF13833
(EF-hand_8) 		5 ILE A  83
ILE A  79
HIS A 143
MET A 110
PHE A  74
 None
 0.92A 1bsxA-4ociA:
undetectable		 1bsxA-4ociA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase) 		5 ILE A 180
ALA A 210
LEU A 265
ILE A 263
HIS A 190
 None
 1.04A 1bsxA-4qmgA:
undetectable		 1bsxA-4qmgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		5 ALA A 228
LEU A 109
LEU A  86
ILE A  83
PHE A 189
 None
 1.17A 1bsxA-4rgpA:
undetectable		 1bsxA-4rgpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq2 PUTATIVE
PHYCOERYTHRIN LYASE

(Guillardia
theta) 		PF09367
(CpeS) 		5 ILE A 151
ILE A 152
ALA A  24
LEU A 161
HIS A 156
 None
 0.92A 1bsxA-4tq2A:
undetectable		 1bsxA-4tq2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Burkholderia
pseudomallei) 		PF06429
(Flg_bbr_C) 		6 ARG A 156
ALA A 148
LEU A 425
LEU A 304
ILE A 107
MET A 580
 None
EDO  A1642 ( 4.3A)
None
None
EDO  A1642 (-4.3A)
None
 1.40A 1bsxA-4ut1A:
undetectable		 1bsxA-4ut1A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		5 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
None
None
ACT  A 410 (-4.8A)
None
 1.15A 1bsxA-4w5zA:
undetectable		 1bsxA-4w5zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1

(Mus musculus) 		no annotation 5 ILE A1644
ALA A1406
LEU A1403
LEU A1613
ILE A1410
 None
 1.12A 1bsxA-4w8pA:
undetectable		 1bsxA-4w8pA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE

(Haemophilus
influenzae) 		PF00106
(adh_short) 		5 ILE A  95
ILE A  97
ALA A  36
LEU A  44
ILE A  59
 None
 1.11A 1bsxA-4wuvA:
undetectable		 1bsxA-4wuvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN

(Homo sapiens) 		PF10421
(OAS1_C) 		5 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.15A 1bsxA-4xq7A:
undetectable		 1bsxA-4xq7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		5 ILE A 182
ILE A 263
ALA A 218
LEU A 183
LEU A 284
 None
 1.07A 1bsxA-4y0iA:
undetectable		 1bsxA-4y0iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 5 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
 None
 1.16A 1bsxA-5a0kA:
undetectable		 1bsxA-5a0kA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coz UNCHARACTERIZED
PROTEIN

([Eubacterium]
rectale) 		no annotation 5 ILE A 110
ILE A 276
LEU A 106
LEU A 267
ILE A 204
 None
 1.01A 1bsxA-5cozA:
undetectable		 1bsxA-5cozA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy4 OLIGORIBONUCLEASE

(Acinetobacter
baumannii) 		PF00929
(RNase_T) 		5 ILE A  27
ILE A  49
ARG A  75
LEU A 117
ILE A  12
 None
 0.90A 1bsxA-5cy4A:
undetectable		 1bsxA-5cy4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		5 ILE A 356
ALA A 341
LEU A 338
LEU A 396
ILE A 461
 None
 0.98A 1bsxA-5e9uA:
undetectable		 1bsxA-5e9uA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 0.96A 1bsxA-5ekuA:
undetectable		 1bsxA-5ekuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		5 ILE A1345
ARG A1414
LEU A1359
LEU A1449
PHE A1401
 None
 1.15A 1bsxA-5ffjA:
undetectable		 1bsxA-5ffjA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ham RICKCE

(Rickettsia
bellii) 		no annotation 5 ILE A 557
ALA A 569
LEU A 567
LEU A 605
ILE A 578
 None
 1.14A 1bsxA-5hamA:
undetectable		 1bsxA-5hamA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj1 PULLULANASE C
PROTEIN

(Klebsiella
pneumoniae) 		no annotation 5 ILE A 239
ALA A 233
LEU A 241
LEU A 186
ILE A 199
 None
VCA  A 301 ( 4.0A)
None
VCA  A 301 ( 4.7A)
None
 1.08A 1bsxA-5hj1A:
undetectable		 1bsxA-5hj1A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1t STAGE II SPORULATION
PROTEIN D

(Clostridioides
difficile) 		PF08486
(SpoIID) 		5 ILE A 236
ILE A 309
LEU A 279
ILE A 252
PHE A 304
 None
 1.14A 1bsxA-5i1tA:
undetectable		 1bsxA-5i1tA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic1 TALIN-1

(Mus musculus) 		no annotation 5 ILE A1644
ALA A1406
LEU A1403
LEU A1613
ILE A1410
 EDO  A1903 (-4.0A)
None
EDO  A1903 ( 4.6A)
None
None
 1.14A 1bsxA-5ic1A:
undetectable		 1bsxA-5ic1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id4 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		5 ILE A 108
ILE A 107
ALA A 194
LEU A 183
ILE A 189
 None
 1.10A 1bsxA-5id4A:
undetectable		 1bsxA-5id4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ILE A 204
ILE A 208
LEU A 227
ILE A 169
PHE A 212
 None
 1.07A 1bsxA-5kc8A:
undetectable		 1bsxA-5kc8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		5 ILE A 690
ILE A 694
LEU A 713
ILE A 655
PHE A 698
 None
 1.01A 1bsxA-5kcaA:
undetectable		 1bsxA-5kcaA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj7 UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF01156
(IU_nuc_hydro) 		5 ILE A 267
ILE A 256
ALA A  25
ILE A  10
PHE A 205
 None
 1.14A 1bsxA-5mj7A:
undetectable		 1bsxA-5mj7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9m COBYRIC ACID
SYNTHASE

(Staphylococcus
aureus) 		no annotation 5 ILE A  24
ILE A  23
LEU A 204
ILE A  35
PHE A  57
 None
 1.05A 1bsxA-5n9mA:
undetectable		 1bsxA-5n9mA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 ILE A  88
ILE A 161
MET A  99
LEU A 379
ILE A 410
 None
 1.06A 1bsxA-5ngkA:
undetectable		 1bsxA-5ngkA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		5 ILE A 238
ALA A 246
LEU A 242
LEU A 145
ILE A 149
 None
 1.11A 1bsxA-5tprA:
undetectable		 1bsxA-5tprA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u81 ACID CERAMIDASE
ISOFORM B

(Heterocephalus
glaber) 		no annotation 5 ILE A 282
ILE A 147
ALA A 337
LEU A 354
ILE A 357
 None
 1.03A 1bsxA-5u81A:
undetectable		 1bsxA-5u81A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v77 UNCHARACTERIZED
PROTEIN

(Neisseria
gonorrhoeae) 		no annotation 5 ILE A  98
ILE A  93
LEU A  11
ILE A  69
PHE A  47
 None
 1.08A 1bsxA-5v77A:
undetectable		 1bsxA-5v77A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		5 ILE O1180
ILE O1108
MET O1119
LEU O1211
LEU O1096
 None
 1.02A 1bsxA-5x0yO:
undetectable		 1bsxA-5x0yO:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 ILE A 165
ALA A 176
LEU A 129
LEU A 136
ILE A 180
 None
 1.15A 1bsxA-5xwbA:
undetectable		 1bsxA-5xwbA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 183
ILE B 158
LEU B 150
LEU B 140
ILE B 107
 None
 1.12A 1bsxA-5y59B:
undetectable		 1bsxA-5y59B:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE

(Komagataella
phaffii) 		no annotation 5 ILE A 374
ILE A 417
ALA A 424
LEU A 355
ILE A 360
 None
 1.17A 1bsxA-5z0yA:
undetectable		 1bsxA-5z0yA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gun -

(-) 		no annotation 5 ILE A  87
ARG A 134
ALA A 164
LEU A 151
LEU A 107
 None
 1.09A 1bsxA-6gunA:
undetectable		 1bsxA-6gunA:
undetectable