SIMILAR PATTERNS OF AMINO ACIDS FOR 1BRP_A_RTLA183_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		5 LEU A 241
PHE A  60
GLY A  41
TYR A 201
LEU A   9
 None
 1.38A 1brpA-1c8uA:
0.5		 1brpA-1c8uA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		5 PHE A  60
GLY A  41
TYR A 201
LEU A   9
HIS A 231
 None
 1.26A 1brpA-1c8uA:
0.5		 1brpA-1c8uA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		5 LEU L 387
PHE L 213
ALA L 391
GLY L 106
TYR L 109
 None
 1.30A 1brpA-1cc1L:
0.0		 1brpA-1cc1L:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 ALA A 408
MET A 409
MET A 421
LEU A 157
HIS A 403
 None
None
None
None
ZN  A 990 ( 3.4A)
 1.43A 1brpA-1ck7A:
0.3		 1brpA-1ck7A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5y ROB TRANSCRIPTION
FACTOR

(Escherichia
coli) 		PF06445
(GyrI-like)
PF12833
(HTH_18) 		5 MET A 248
GLY A 245
TYR A 244
LEU A 253
PHE A 239
 None
 1.21A 1brpA-1d5yA:
undetectable		 1brpA-1d5yA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		5 LEU A 170
PHE A 530
GLY A 140
LEU A  80
PHE A 215
 None
 1.38A 1brpA-1dl2A:
undetectable		 1brpA-1dl2A:
15.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 ALA A  43
PHE A  77
MET A  88
HIS A 104
PHE A 135
 RTL  A 176 ( 4.1A)
None
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.7A)
RTL  A 176 ( 4.2A)
 1.00A 1brpA-1iiuA:
31.3		 1brpA-1iiuA:
84.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 ALA A  57
GLY A  75
PHE A  77
MET A  88
PHE A 137
 RTL  A 176 ( 3.8A)
RTL  A 176 ( 4.0A)
None
RTL  A 176 (-3.4A)
None
 1.16A 1brpA-1iiuA:
31.3		 1brpA-1iiuA:
84.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		6 LEU A  37
ALA A  57
MET A  73
LEU A  97
GLN A  98
HIS A 117
 RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.6A)
 1.33A 1brpA-1iiuA:
31.3		 1brpA-1iiuA:
84.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 LEU A  37
MET A  73
PHE A  45
LEU A  97
PHE A 135
 RTL  A 176 ( 4.5A)
RTL  A 176 ( 4.0A)
RTL  A 176 ( 4.8A)
RTL  A 176 (-4.0A)
RTL  A 176 ( 4.2A)
 1.20A 1brpA-1iiuA:
31.3		 1brpA-1iiuA:
84.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		12 LEU A  37
PHE A  45
ALA A  57
MET A  73
GLY A  75
PHE A  77
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
PHE A 135
 RTL  A 176 ( 4.5A)
RTL  A 176 ( 4.8A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 4.0A)
RTL  A 176 ( 4.0A)
None
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.7A)
RTL  A 176 ( 4.2A)
 0.33A 1brpA-1iiuA:
31.3		 1brpA-1iiuA:
84.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		5 PHE A 197
ALA A 268
PHE A 239
TYR A 208
GLN A 257
 None
 1.40A 1brpA-1lwdA:
0.2		 1brpA-1lwdA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		5 LEU A  35
ALA A 524
GLY A  46
TYR A  44
GLN A  40
 None
None
None
None
ACT  A 562 ( 4.0A)
 1.12A 1brpA-1n7uA:
0.3		 1brpA-1n7uA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 341
PHE A 455
PHE A 459
MET A 310
HIS A 435
 None
G24  A 462 (-3.8A)
None
G24  A 462 ( 3.8A)
G24  A 462 (-3.9A)
 1.38A 1brpA-1q4xA:
undetectable		 1brpA-1q4xA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ti8 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A 177
PHE A 245
GLY A 181
PHE A 251
LEU A  67
 None
 1.33A 1brpA-1ti8A:
undetectable		 1brpA-1ti8A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		5 LEU A 125
GLY A 114
MET A 111
TYR A  85
LEU A  35
 None
 0.94A 1brpA-1uarA:
undetectable		 1brpA-1uarA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		5 LEU A 191
ALA A 203
MET A 171
GLY A 169
LEU A  96
 None
 1.22A 1brpA-1v8dA:
undetectable		 1brpA-1v8dA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1e 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 LEU A  52
PHE A 181
ALA A  78
GLY A  15
LEU A  74
 None
 1.13A 1brpA-1x1eA:
undetectable		 1brpA-1x1eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389

(Mycobacterium
tuberculosis) 		PF13523
(Acetyltransf_8) 		5 LEU A 129
ALA A 131
GLY A 144
LEU A  45
PHE A 167
 None
 1.19A 1brpA-1yk3A:
2.4		 1brpA-1yk3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3j U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU A  50
ALA A  75
GLY A  73
LEU A 102
GLN A  98
 None
 0.87A 1brpA-2a3jA:
undetectable		 1brpA-2a3jA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 300
MET A 656
GLY A 661
PHE A 453
LEU A 293
 None
 1.35A 1brpA-2d3tA:
undetectable		 1brpA-2d3tA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 300
MET A 656
GLY A 661
PHE A 453
TYR A 660
 None
 1.35A 1brpA-2d3tA:
undetectable		 1brpA-2d3tA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddu REELIN

(Mus musculus) 		no annotation 5 LEU A1592
ALA A1494
GLY A1468
LEU A1532
PHE A1455
 None
 1.41A 1brpA-2dduA:
undetectable		 1brpA-2dduA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 LEU A 388
ALA A 378
GLY A 497
LEU A 372
PHE A 636
 None
 1.26A 1brpA-2dkhA:
undetectable		 1brpA-2dkhA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzh TRYPTOPHAN
BIOSYNTHESIS PROTEIN
TRPCF

(Escherichia
coli) 		PF00697
(PRAI) 		5 LEU A  28
ALA A  43
LEU A  52
GLN A  53
PHE A  30
 None
 1.40A 1brpA-2kzhA:
undetectable		 1brpA-2kzhA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsz PROGRAMMED CELL
DEATH PROTEIN 4

(Mus musculus) 		PF02847
(MA3) 		5 LEU A 387
ALA A 367
TYR A 338
LEU A 351
PHE A 429
 None
 1.18A 1brpA-2nszA:
undetectable		 1brpA-2nszA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		5 LEU A 181
ALA A 204
GLY A 277
MET A 280
LEU A 269
 None
 1.31A 1brpA-2pfyA:
undetectable		 1brpA-2pfyA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		5 ALA A 213
GLY A 209
TYR A 208
LEU A 219
GLN A 221
 None
 1.28A 1brpA-2q3oA:
undetectable		 1brpA-2q3oA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rh3 PROTEIN VIRC2

(Agrobacterium
tumefaciens) 		PF07181
(VirC2) 		5 LEU A 120
PHE A 181
LEU A 112
GLN A 113
PHE A 158
 None
 1.42A 1brpA-2rh3A:
undetectable		 1brpA-2rh3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA

(Aspergillus
nidulans) 		PF05368
(NmrA) 		5 PHE A 181
PHE A 165
TYR A 153
LEU A 218
GLN A  17
 None
None
NAD  A1353 (-3.5A)
None
NAD  A1353 (-4.4A)
 1.09A 1brpA-2vutA:
undetectable		 1brpA-2vutA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vza CELL FILAMENTATION
PROTEIN

(Bartonella
henselae) 		PF02661
(Fic) 		5 LEU A  68
GLY A 122
LEU A 130
HIS A  88
PHE A 161
 None
 1.42A 1brpA-2vzaA:
undetectable		 1brpA-2vzaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A 294
PHE A 529
LEU A 299
HIS A 398
PHE A 401
 None
 1.40A 1brpA-2wdaA:
undetectable		 1brpA-2wdaA:
12.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  43
PHE A  77
MET A  88
HIS A 104
PHE A 135
 OLA  A1179 ( 4.0A)
None
OLA  A1179 ( 3.8A)
OLA  A1179 (-4.5A)
OLA  A1179 (-4.3A)
 1.00A 1brpA-2wq9A:
32.2		 1brpA-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  37
MET A  73
PHE A  45
LEU A  97
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.9A)
OLA  A1179 (-4.6A)
None
OLA  A1179 (-4.3A)
 1.29A 1brpA-2wq9A:
32.2		 1brpA-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		12 LEU A  37
PHE A  45
ALA A  57
MET A  73
GLY A  75
PHE A  77
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 (-4.6A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 (-3.8A)
None
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 (-4.3A)
 0.39A 1brpA-2wq9A:
32.2		 1brpA-2wq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU X 389
ALA X 378
GLY X 355
LEU X 369
PHE X 600
 None
 1.13A 1brpA-2y9eX:
undetectable		 1brpA-2y9eX:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		5 PHE A 246
ALA A   9
GLY A 242
MET A 240
LEU A 176
 None
 1.37A 1brpA-2yn0A:
undetectable		 1brpA-2yn0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejw SMLSRB

(Sinorhizobium
meliloti) 		PF13407
(Peripla_BP_4) 		5 LEU A 110
PHE A 305
PHE A 315
LEU A 298
PHE A 220
 None
 1.38A 1brpA-3ejwA:
undetectable		 1brpA-3ejwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 303
ALA A  56
MET A  60
MET A  76
LEU A 333
 None
 1.34A 1brpA-3fgqA:
undetectable		 1brpA-3fgqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		5 ALA A  94
MET A  95
GLY A  92
PHE A  91
PHE A 229
 CL  A 268 (-3.5A)
None
None
None
None
 1.14A 1brpA-3flbA:
undetectable		 1brpA-3flbA:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  43
PHE A  77
MET A  88
HIS A 104
PHE A 135
 2T1  A 184 ( 4.7A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.7A)
2T1  A 184 (-4.8A)
 1.11A 1brpA-3fmzA:
30.4		 1brpA-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  57
MET A  73
GLY A  75
MET A  88
PHE A 137
 2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.1A)
None
 1.36A 1brpA-3fmzA:
30.4		 1brpA-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		9 LEU A  37
PHE A  45
ALA A  57
GLY A  75
PHE A  77
MET A  88
TYR A  90
HIS A 104
PHE A 135
 2T1  A 184 (-3.6A)
None
2T1  A 184 (-3.6A)
2T1  A 184 (-3.8A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.7A)
2T1  A 184 (-4.8A)
 0.45A 1brpA-3fmzA:
30.4		 1brpA-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		9 LEU A  37
PHE A  45
ALA A  57
MET A  73
GLY A  75
PHE A  77
MET A  88
TYR A  90
PHE A 135
 2T1  A 184 (-3.6A)
None
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.8A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-4.8A)
 0.71A 1brpA-3fmzA:
30.4		 1brpA-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  45
ALA A  57
GLY A  75
PHE A  77
MET A  88
TYR A  90
GLN A  98
HIS A 104
 None
2T1  A 184 (-3.6A)
2T1  A 184 (-3.8A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 0.67A 1brpA-3fmzA:
30.4		 1brpA-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  45
ALA A  57
MET A  73
GLY A  75
PHE A  77
MET A  88
TYR A  90
GLN A  98
 None
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.8A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
 0.89A 1brpA-3fmzA:
30.4		 1brpA-3fmzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A

(Homo sapiens) 		PF04139
(Rad9) 		5 LEU A 256
PHE A  84
ALA A  16
PHE A  80
LEU A 225
 None
 1.39A 1brpA-3ggrA:
undetectable		 1brpA-3ggrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		5 PHE A 496
ALA A 224
MET A 227
GLY A 456
PHE A 500
 None
 1.22A 1brpA-3gyxA:
undetectable		 1brpA-3gyxA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III

(Ruegeria
pomeroyi) 		PF00202
(Aminotran_3) 		5 LEU A 106
ALA A 333
GLN A 104
HIS A  96
PHE A 119
 None
 1.36A 1brpA-3hmuA:
undetectable		 1brpA-3hmuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 LEU A 299
GLY A 257
PHE A   7
TYR A 255
PHE A 319
 None
 1.32A 1brpA-3imlA:
undetectable		 1brpA-3imlA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		5 LEU A  74
MET A   7
GLY A  51
LEU A  34
HIS A 170
 None
 1.35A 1brpA-3m3pA:
undetectable		 1brpA-3m3pA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owt DNA-BINDING PROTEIN
RAP1

(Saccharomyces
cerevisiae) 		PF11626
(Rap1_C) 		5 PHE A 707
PHE A 773
MET A 772
TYR A 768
LEU A 755
 None
 1.36A 1brpA-3owtA:
undetectable		 1brpA-3owtA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 LEU A  19
ALA A 331
GLY A 302
LEU A 338
PHE A  76
 None
 1.36A 1brpA-3qj4A:
undetectable		 1brpA-3qj4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 212
ALA A  81
GLY A  73
TYR A  72
PHE A  67
 None
 1.21A 1brpA-3r44A:
undetectable		 1brpA-3r44A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 LEU A 212
ALA A  81
GLY A  73
TYR A  72
PHE A  67
 None
 1.28A 1brpA-3t5bA:
undetectable		 1brpA-3t5bA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		5 LEU A 403
ALA A 367
PHE A  54
LEU A 398
PHE A 324
 None
 1.42A 1brpA-3x0vA:
undetectable		 1brpA-3x0vA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 296
ALA A 108
GLY A 110
MET A 347
PHE A 140
 None
 1.40A 1brpA-4aj9A:
3.1		 1brpA-4aj9A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		5 LEU A 486
PHE A 651
ALA A 561
PHE A 524
LEU A 517
 None
 1.34A 1brpA-4c4aA:
undetectable		 1brpA-4c4aA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Sulfolobus
solfataricus) 		PF00215
(OMPdecase) 		5 LEU A  47
MET A  10
GLY A  32
PHE A  60
LEU A  14
 None
 1.37A 1brpA-4dbeA:
undetectable		 1brpA-4dbeA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri) 		PF02655
(ATP-grasp_3) 		5 ALA A 242
MET A 224
GLY A 222
PHE A 268
LEU A 214
 None
 1.32A 1brpA-4fflA:
undetectable		 1brpA-4fflA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA

(Arabidopsis
thaliana) 		PF03770
(IPK) 		5 PHE A  46
PHE A  50
TYR A  63
LEU A 202
GLN A 201
 None
 1.41A 1brpA-4frfA:
undetectable		 1brpA-4frfA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 PHE A 438
ALA A 177
MET A 227
MET A 281
LEU A 213
 0XZ  A 501 (-4.8A)
0XZ  A 501 (-3.3A)
0XZ  A 501 (-3.8A)
0XZ  A 501 (-3.5A)
None
 1.34A 1brpA-4gv1A:
undetectable		 1brpA-4gv1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		5 ALA B 103
GLY B 122
PHE B 123
LEU B 118
PHE B  78
 None
 1.31A 1brpA-4hxeB:
undetectable		 1brpA-4hxeB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj6 ACETYL XYLAN
ESTERASE

(Geobacillus
stearothermophilus) 		PF13472
(Lipase_GDSL_2) 		5 LEU A  44
PHE A  11
ALA A 204
MET A 201
GLY A  36
 None
None
None
None
GOL  A 304 (-3.7A)
 1.32A 1brpA-4jj6A:
undetectable		 1brpA-4jj6A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 LEU A 640
PHE A  21
TYR A 702
LEU A 592
HIS A 679
 None
 1.19A 1brpA-4krfA:
undetectable		 1brpA-4krfA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 LEU A 323
GLY A 281
PHE A  25
TYR A 279
PHE A 343
 None
 1.29A 1brpA-4odjA:
undetectable		 1brpA-4odjA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		5 LEU A  52
ALA A  78
GLY A  57
GLN A  90
PHE A  45
 None
 1.38A 1brpA-4pmzA:
undetectable		 1brpA-4pmzA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		5 LEU A 241
PHE A  60
GLY A  41
TYR A 201
LEU A   9
 None
 1.37A 1brpA-4qfwA:
undetectable		 1brpA-4qfwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		5 PHE A  60
GLY A  41
TYR A 201
LEU A   9
HIS A 231
 None
 1.23A 1brpA-4qfwA:
undetectable		 1brpA-4qfwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 PHE A1431
ALA A1736
GLY A1738
PHE A1713
LEU A1706
 None
 1.42A 1brpA-4rh7A:
undetectable		 1brpA-4rh7A:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		5 ALA A 175
MET A 174
GLY A 178
TYR A 181
LEU A  23
 None
 1.35A 1brpA-4u2mA:
undetectable		 1brpA-4u2mA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		5 LEU A 135
ALA A 149
GLY A 145
LEU A 162
GLN A 138
 None
 1.35A 1brpA-4x8fA:
undetectable		 1brpA-4x8fA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		5 PHE A 180
ALA A 174
GLY A 201
LEU A 211
PHE A 252
 None
 1.18A 1brpA-4yisA:
undetectable		 1brpA-4yisA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 5 ALA A 576
GLY A 337
TYR A 339
GLN A 345
HIS A 355
 None
 1.30A 1brpA-5aa6A:
undetectable		 1brpA-5aa6A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 PHE A 545
ALA A 542
GLY A 537
PHE A 223
LEU A 419
 None
None
JAA  A 601 (-3.1A)
None
None
 1.20A 1brpA-5ecoA:
undetectable		 1brpA-5ecoA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		5 LEU A 931
PHE A 497
GLY A 486
PHE A 483
PHE A 959
 None
 1.40A 1brpA-5fswA:
undetectable		 1brpA-5fswA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5f TAU CLASS
GLUTATHIONE
S-TRANSFERASE

(Mangifera
indica) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 103
PHE A 197
GLY A 157
TYR A 158
PHE A 166
 None
None
PEG  A1226 (-3.4A)
None
None
 1.15A 1brpA-5g5fA:
undetectable		 1brpA-5g5fA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 LEU A 248
ALA A 451
GLY A 456
TYR A 457
PHE A 515
 None
 1.33A 1brpA-5gslA:
undetectable		 1brpA-5gslA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN

(Pedobacter
heparinus) 		PF16265
(DUF4918) 		6 LEU A  60
PHE A 228
PHE A 116
TYR A 121
LEU A 166
GLN A 165
 None
 1.27A 1brpA-5h0kA:
undetectable		 1brpA-5h0kA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb5 NUCLEOPORIN NUP145

(Chaetomium
thermophilum) 		PF04096
(Nucleoporin2) 		5 LEU A  88
PHE A 136
ALA A  64
PHE A  38
PHE A 131
 None
 1.22A 1brpA-5hb5A:
undetectable		 1brpA-5hb5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmm EXODEOXYRIBONUCLEASE

(Escherichia
virus T5) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		5 ALA A 129
GLY A  27
PHE A 112
LEU A 149
PHE A 281
 None
 1.32A 1brpA-5hmmA:
undetectable		 1brpA-5hmmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 PHE A 259
ALA A 194
GLY A 172
PHE A 201
LEU A  93
 None
None
OAS  A 169 ( 3.1A)
None
None
 1.39A 1brpA-5jd5A:
undetectable		 1brpA-5jd5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		5 PHE A 483
ALA A  93
MET A  94
PHE A 104
TYR A  91
 None
 1.25A 1brpA-5jjtA:
undetectable		 1brpA-5jjtA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8

(Homo sapiens) 		no annotation 5 LEU A 433
ALA A 456
GLY A 451
HIS A 445
PHE A 414
 6S8  A 601 ( 4.8A)
6S8  A 601 ( 3.8A)
None
6S8  A 601 (-3.9A)
6S8  A 601 (-4.6A)
 1.10A 1brpA-5kdiA:
undetectable		 1brpA-5kdiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzh BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		5 ALA A  72
GLY A  66
PHE A  45
TYR A  65
GLN A  63
 None
 1.07A 1brpA-5kzhA:
undetectable		 1brpA-5kzhA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 LEU A 662
ALA A 671
GLY A 681
LEU A 644
GLN A 642
 None
 1.27A 1brpA-5l46A:
undetectable		 1brpA-5l46A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 560
ALA A 448
GLY A 443
LEU A 583
PHE A 130
 None
 1.41A 1brpA-5lewA:
undetectable		 1brpA-5lewA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oow CHAPERONE PROTEIN
DNAK

(Escherichia
coli) 		no annotation 5 LEU A 324
ALA A 191
PHE A 200
LEU A 219
PHE A 356
 None
 1.42A 1brpA-5oowA:
undetectable		 1brpA-5oowA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		5 LEU A  82
GLY A  32
PHE A  14
HIS A  46
PHE A  47
 None
 1.23A 1brpA-5tf2A:
undetectable		 1brpA-5tf2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 5 LEU A 120
MET A 137
GLY A 123
PHE A  37
LEU A 104
 None
 1.34A 1brpA-5tu4A:
undetectable		 1brpA-5tu4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 LEU A1363
GLY A1117
PHE A 505
LEU A1285
PHE A1049
 None
 1.26A 1brpA-5wlhA:
undetectable		 1brpA-5wlhA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 LEU A 530
ALA A 440
MET A 436
PHE A 504
LEU A 461
 None
 1.28A 1brpA-5wu7A:
undetectable		 1brpA-5wu7A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A

(Danio rerio;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A1015
ALA A1063
GLY A1030
LEU A1046
PHE A 132
 None
 1.40A 1brpA-5xszA:
undetectable		 1brpA-5xszA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 LEU A 399
ALA A 316
LEU A 336
HIS A 519
PHE A 495
 None
 1.38A 1brpA-5y86A:
undetectable		 1brpA-5y86A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 PHE A 449
ALA A 361
PHE A 490
LEU A 384
GLN A 385
 None
SEB  A 360 ( 3.7A)
None
None
None
 1.41A 1brpA-5ydjA:
undetectable		 1brpA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 LEU A 247
PHE A 327
ALA A 237
GLY A 240
HIS A 255
 None
 1.29A 1brpA-5za2A:
undetectable		 1brpA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME

(Trypanosoma
brucei) 		no annotation 5 LEU E 114
ALA E 158
GLY E 162
TYR E 180
PHE E  41
 None
None
None
PGE  E 402 (-4.8A)
None
 1.38A 1brpA-6bm7E:
undetectable		 1brpA-6bm7E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 612
GLY A 584
TYR A 585
LEU A 638
GLN A 634
 None
 1.21A 1brpA-6c6lA:
undetectable		 1brpA-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 5 PHE A 131
GLY A  92
PHE A  74
LEU A 239
GLN A 238
 None
 1.21A 1brpA-6enoA:
undetectable		 1brpA-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gi2 FERRIC ENTEROBACTIN
ESTERASE

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A  67
ALA A  85
GLY A  87
LEU A 262
PHE A  22
 None
 1.39A 1brpA-6gi2A:
undetectable		 1brpA-6gi2A:
undetectable