SIMILAR PATTERNS OF AMINO ACIDS FOR 1AZM_A_AZMA262_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		4 PHE 1 112
LEU 3 102
THR 3 101
HIS 3 105
 None
 1.04A 1azmA-1bev1:
undetectable		 1azmA-1bev1:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1en4 MANGANESE SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 PHE A  18
HIS A  26
HIS A  81
TRP A 128
 None
MN  A 501 (-3.4A)
MN  A 501 (-3.4A)
None
 1.04A 1azmA-1en4A:
undetectable		 1azmA-1en4A:
24.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
None
 0.21A 1azmA-1jd0A:
35.5		 1azmA-1jd0A:
37.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A1022
HIS A 103
HIS A 978
LEU A1018
HIS A 163
 CU  A1051 (-3.2A)
CU  A1051 (-3.3A)
CU  A1052 ( 3.2A)
None
CU  A1050 (-3.3A)
 1.39A 1azmA-1kcwA:
undetectable		 1azmA-1kcwA:
12.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 HIS A  92
HIS A  94
HIS A 111
LEU A 176
THR A 177
TRP A 187
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
None
 0.38A 1azmA-1kopA:
29.7		 1azmA-1kopA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 HIS A  80
HIS A 128
HIS A  79
HIS A 270
 CUZ  A 801 (-3.3A)
CUZ  A 801 (-3.1A)
CUZ  A 801 (-3.3A)
CUZ  A 801 (-3.3A)
 1.06A 1azmA-1qniA:
undetectable		 1azmA-1qniA:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
None
 0.31A 1azmA-1rj6A:
36.0		 1azmA-1rj6A:
35.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 HIS A 277
HIS A 263
THR A 199
HIS A 200
 ZN  A 387 (-3.3A)
ZN  A 387 ( 3.3A)
None
ZN  A 387 ( 3.3A)
 1.06A 1azmA-1rrmA:
undetectable		 1azmA-1rrmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to5 SUPEROXIDE DISMUTASE

(Schistosoma
mansoni) 		PF00080
(Sod_Cu) 		4 HIS A  62
HIS A  45
HIS A  70
HIS A 119
 ZN  A 711 ( 3.1A)
CU  A 712 (-3.3A)
ZN  A 711 (-3.1A)
CU  A 712 (-3.2A)
 1.06A 1azmA-1to5A:
undetectable		 1azmA-1to5A:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
 0.29A 1azmA-1urtA:
36.6		 1azmA-1urtA:
44.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		4 PHE A  73
HIS A  52
HIS A 139
LEU A 142
 None
 1.06A 1azmA-1vzvA:
undetectable		 1azmA-1vzvA:
23.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		6 HIS A 115
HIS A 117
HIS A 135
LEU A 216
THR A 217
TRP A 227
 ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ZN  A 283 ( 3.1A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
None
 0.17A 1azmA-1y7wA:
25.3		 1azmA-1y7wA:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 HIS A  95
HIS A  70
HIS A 104
HIS A 151
 ZN  A 201 ( 3.1A)
CU  A 200 (-3.1A)
ZN  A 201 (-3.1A)
CU  A 200 (-3.2A)
 1.07A 1azmA-1z9pA:
undetectable		 1azmA-1z9pA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]

(Neisseria
meningitidis) 		no annotation 4 HIS C 104
HIS C  79
HIS C 113
HIS C 160
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.1A)
ZN  C 201 (-3.2A)
CU1  C 200 (-3.2A)
 1.06A 1azmA-2aqtC:
undetectable		 1azmA-2aqtC:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		4 PHE A 233
HIS A 251
LEU A 370
THR A 369
 None
 1.00A 1azmA-2b0tA:
undetectable		 1azmA-2b0tA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		4 PHE D 324
HIS D 320
LEU D 282
THR D 279
 None
 0.73A 1azmA-2gafD:
undetectable		 1azmA-2gafD:
17.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 PHE A  91
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
HIS A 200
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
PPF  A 500 (-3.9A)
None
 0.25A 1azmA-2it4A:
44.2		 1azmA-2it4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 HIS A  78
HIS A  76
HIS A 137
HIS A 285
 ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
None
ZN  A 493 (-3.5A)
 1.02A 1azmA-2pajA:
undetectable		 1azmA-2pajA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peb PUTATIVE DIOXYGENASE

(Nostoc
punctiforme) 		PF08883
(DOPA_dioxygen) 		4 PHE A  44
HIS A  14
HIS A  84
HIS A  12
 None
ZN  A 200 ( 3.1A)
ZN  A 200 ( 3.4A)
ZN  A 200 ( 3.1A)
 0.97A 1azmA-2pebA:
undetectable		 1azmA-2pebA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph0 UNCHARACTERIZED
PROTEIN

(Pectobacterium
carotovorum) 		PF06228
(ChuX_HutX) 		4 PHE A 126
HIS A  66
LEU A  17
THR A  16
 None
 0.92A 1azmA-2ph0A:
undetectable		 1azmA-2ph0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		4 HIS A 237
HIS A 235
HIS A 255
LEU A 202
 MET  A 600 (-3.9A)
MET  A 600 (-4.4A)
MET  A 600 ( 4.3A)
MET  A 600 (-3.7A)
 0.83A 1azmA-2qs8A:
undetectable		 1azmA-2qs8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		4 HIS A 255
HIS A 237
HIS A 235
LEU A 202
 MET  A 600 ( 4.3A)
MET  A 600 (-3.9A)
MET  A 600 (-4.4A)
MET  A 600 (-3.7A)
 0.96A 1azmA-2qs8A:
undetectable		 1azmA-2qs8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 HIS A  62
HIS A  60
HIS A 125
HIS A 249
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
None
None
 1.06A 1azmA-2qt3A:
undetectable		 1azmA-2qt3A:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 118
HIS A 141
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
 0.33A 1azmA-2w2jA:
35.0		 1azmA-2w2jA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
ZN  A   1 ( 4.7A)
None
 0.34A 1azmA-2zncA:
30.0		 1azmA-2zncA:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 163
HIS A 165
HIS A 182
LEU A 259
THR A 260
TRP A 270
 ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 (-3.1A)
None
ZN  A 378 ( 4.5A)
None
 0.19A 1azmA-3b1bA:
24.4		 1azmA-3b1bA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3caw O-SUCCINYLBENZOATE
SYNTHASE

(Bdellovibrio
bacteriovorus) 		no annotation 4 PHE A  93
LEU A 284
THR A 285
HIS A 286
 None
 1.03A 1azmA-3cawA:
undetectable		 1azmA-3cawA:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  95
HIS A  97
HIS A 120
LEU A 199
THR A 200
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 0.47A 1azmA-3da2A:
42.0		 1azmA-3da2A:
59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 PHE A 132
HIS A  95
HIS A  97
LEU A 199
THR A 200
TRP A 210
 4MD  A 401 (-4.6A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 1.00A 1azmA-3da2A:
42.0		 1azmA-3da2A:
59.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 PHE A  39
HIS A  29
THR A 141
TRP A 333
 None
 1.00A 1azmA-3dtyA:
undetectable		 1azmA-3dtyA:
17.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 111
HIS A 113
HIS A 138
LEU A 219
THR A 220
TRP A 230
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
 0.64A 1azmA-3fe4A:
30.5		 1azmA-3fe4A:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 165
HIS A 138
HIS A 113
THR A 220
 None
MG  A 901 (-3.2A)
MG  A 901 (-3.4A)
None
 1.03A 1azmA-3fe4A:
30.5		 1azmA-3fe4A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 HIS A  63
HIS A  61
HIS A 122
HIS A 246
 FE  A 502 (-3.1A)
FE  A 502 (-3.1A)
None
FE  A 502 ( 4.8A)
 0.97A 1azmA-3g77A:
undetectable		 1azmA-3g77A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l CYTOCHROME B

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 HIS C  98
LEU C 198
THR C 194
HIS C 197
 HEM  C 502 (-3.2A)
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.9A)
HEM  C 502 (-3.2A)
 1.06A 1azmA-3h1lC:
undetectable		 1azmA-3h1lC:
20.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 129
LEU A 235
THR A 236
TRP A 246
 None
 0.31A 1azmA-3jxfA:
32.7		 1azmA-3jxfA:
31.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 166
HIS A 129
THR A 236
TRP A 246
 None
 0.78A 1azmA-3jxfA:
32.7		 1azmA-3jxfA:
31.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
None
 0.23A 1azmA-3ml5A:
40.2		 1azmA-3ml5A:
50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 131
HIS A  96
THR A 199
TRP A 209
 AZM  A 264 (-4.4A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
None
 0.75A 1azmA-3ml5A:
40.2		 1azmA-3ml5A:
50.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 HIS A 277
HIS A 263
THR A 197
HIS A 198
 NAD  A1385 ( 3.6A)
FE2  A 501 (-3.3A)
None
FE2  A 501 (-3.3A)
 0.99A 1azmA-3ox4A:
undetectable		 1azmA-3ox4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 HIS A 117
HIS A  93
LEU A 211
THR A  49
 None
 1.03A 1azmA-3pkjA:
undetectable		 1azmA-3pkjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		6 HIS A 123
HIS A 125
HIS A 142
LEU A 214
THR A 215
TRP A 225
 ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 3.2A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-4.9A)
 0.35A 1azmA-3q31A:
23.5		 1azmA-3q31A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 4 HIS A 130
HIS A 178
HIS A 129
HIS A 326
 CUK  A 702 (-3.2A)
CUK  A 702 (-3.1A)
CUK  A 702 (-3.5A)
CUK  A 702 (-3.1A)
 0.98A 1azmA-3sbqA:
undetectable		 1azmA-3sbqA:
16.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A  96
HIS A 119
THR A 198
TRP A 208
 ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
ZN  A 261 ( 4.4A)
None
 0.27A 1azmA-3uyqA:
41.0		 1azmA-3uyqA:
54.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 119
HIS A  94
HIS A  96
THR A 199
 ZN  A 261 (-3.2A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
 1.05A 1azmA-3uyqA:
41.0		 1azmA-3uyqA:
54.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 130
HIS A  96
THR A 198
TRP A 208
 None
ZN  A 261 (-3.3A)
ZN  A 261 ( 4.4A)
None
 0.87A 1azmA-3uyqA:
41.0		 1azmA-3uyqA:
54.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		4 PHE A 246
HIS A 209
HIS A 207
THR A  63
 FUD  A 301 (-4.7A)
MN  A 302 ( 3.2A)
None
None
 1.03A 1azmA-3vnkA:
undetectable		 1azmA-3vnkA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 HIS A 117
HIS A  93
LEU A 211
THR A  49
 None
 1.01A 1azmA-3zg6A:
undetectable		 1azmA-3zg6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 183
HIS A 179
HIS A 209
HIS A  69
 CUO  A9001 (-3.4A)
CUO  A9001 (-3.4A)
None
CUO  A9001 (-3.1A)
 0.99A 1azmA-4bedA:
undetectable		 1azmA-4bedA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 491
HIS A 633
HIS A 602
LEU A 620
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.3A)
CUO  A9002 (-3.4A)
None
 0.94A 1azmA-4bedA:
undetectable		 1azmA-4bedA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 905
HIS A1046
HIS A1015
LEU A1033
 CUO  A9003 (-3.5A)
CUO  A9003 (-3.2A)
CUO  A9003 (-3.1A)
None
 1.03A 1azmA-4bedA:
undetectable		 1azmA-4bedA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1428
HIS A1424
HIS A1454
HIS A1320
 CUO  A9004 (-3.4A)
CUO  A9004 (-3.0A)
None
CUO  A9004 (-3.5A)
 1.05A 1azmA-4bedA:
undetectable		 1azmA-4bedA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B1851
HIS B1847
HIS B1877
HIS B1734
 CUO  B9005 (-3.2A)
CUO  B9005 (-3.2A)
None
CUO  B9005 (-3.4A)
 1.03A 1azmA-4bedB:
undetectable		 1azmA-4bedB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2264
HIS B2260
HIS B2290
HIS B2150
 CUO  B9006 (-3.2A)
CUO  B9006 (-3.2A)
None
CUO  B9006 (-3.3A)
 1.01A 1azmA-4bedB:
undetectable		 1azmA-4bedB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2570
HIS B2701
HIS B2670
LEU B2688
 CUO  B9007 (-3.3A)
CUO  B9007 (-3.1A)
CUO  B9007 (-3.4A)
None
 0.99A 1azmA-4bedB:
undetectable		 1azmA-4bedB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2674
HIS B2670
HIS B2700
HIS B2570
 CUO  B9007 (-3.4A)
CUO  B9007 (-3.4A)
None
CUO  B9007 (-3.3A)
 1.05A 1azmA-4bedB:
undetectable		 1azmA-4bedB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 PHE B1741
HIS B1878
HIS B1847
HIS B1734
 None
CUO  B9005 (-3.3A)
CUO  B9005 (-3.2A)
CUO  B9005 (-3.4A)
 1.06A 1azmA-4bedB:
undetectable		 1azmA-4bedB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzg ALDOSE 1-EPIMERASE

(Bacillus
subtilis) 		PF01263
(Aldose_epim) 		4 HIS A 101
LEU A  63
THR A  62
HIS A 177
 MAL  A 500 (-4.4A)
MAL  A 500 ( 4.5A)
MAL  A 500 (-4.1A)
MAL  A 500 (-4.0A)
 1.02A 1azmA-4bzgA:
undetectable		 1azmA-4bzgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 HIS A  75
HIS A  73
HIS A 107
THR A 253
 None
 1.05A 1azmA-4cnsA:
undetectable		 1azmA-4cnsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 HIS A  75
HIS A  73
HIS A 107
THR A 253
 None
 1.06A 1azmA-4cntA:
undetectable		 1azmA-4cntA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 HIS A 242
HIS A 164
LEU A 239
THR A 240
 None
 1.01A 1azmA-4dyjA:
undetectable		 1azmA-4dyjA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
HIS A  91
HIS A 108
LEU A 173
THR A 174
TRP A 184
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
 0.27A 1azmA-4g7aA:
28.5		 1azmA-4g7aA:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR

(Homo sapiens) 		PF00415
(RCC1) 		4 HIS C  46
LEU C 100
THR C  99
HIS C  98
 None
 1.04A 1azmA-4jhpC:
undetectable		 1azmA-4jhpC:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 HIS A 120
HIS A  48
HIS A 234
TRP A 148
 None
 0.61A 1azmA-4jqsA:
undetectable		 1azmA-4jqsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le6 ORGANOPHOSPHORUS
HYDROLASE

(Pseudomonas
pseudoalcaligenes) 		PF00753
(Lactamase_B) 		4 HIS A 139
HIS A 230
LEU A 250
HIS A 294
 ZN  A 405 (-3.3A)
None
None
ZN  A 406 (-3.2A)
 1.01A 1azmA-4le6A:
undetectable		 1azmA-4le6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbu SIMILAR TO
N-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF13420
(Acetyltransf_4) 		4 PHE A  70
HIS A 137
LEU A 141
THR A 140
 None
CD  A 204 ( 3.6A)
None
None
 1.05A 1azmA-4mbuA:
undetectable		 1azmA-4mbuA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 HIS A 127
HIS A 126
HIS A 171
TRP A 224
 None
GOL  A 622 (-3.3A)
GOL  A 622 (-4.2A)
GOL  A 622 (-4.5A)
 0.86A 1azmA-4pspA:
undetectable		 1azmA-4pspA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
 0.19A 1azmA-4qk3A:
38.6		 1azmA-4qk3A:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 PHE A 131
HIS A  96
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
 1.07A 1azmA-4qk3A:
38.6		 1azmA-4qk3A:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		5 HIS A 185
HIS A 253
HIS A 187
LEU A 349
HIS A 321
 ZN  A 501 (-3.6A)
ZN  A 501 ( 3.5A)
ZN  A 501 ( 3.4A)
3PE  A 503 ( 4.6A)
3PE  A 503 (-3.8A)
 1.49A 1azmA-4qn9A:
undetectable		 1azmA-4qn9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		5 HIS A 185
HIS A 253
HIS A 187
LEU A 349
HIS A 343
 ZN  A 501 (-3.6A)
ZN  A 501 ( 3.5A)
ZN  A 501 ( 3.4A)
3PE  A 503 ( 4.6A)
ZN  A 502 ( 3.6A)
 1.44A 1azmA-4qn9A:
undetectable		 1azmA-4qn9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 HIS A  58
HIS A  56
HIS A 117
HIS A 241
 FE2  A 502 ( 3.5A)
FE2  A 502 (-3.4A)
None
FE2  A 502 ( 3.7A)
 0.96A 1azmA-4r85A:
undetectable		 1azmA-4r85A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG

(Homo sapiens) 		PF00515
(TPR_1)
PF12895
(ANAPC3)
PF13181
(TPR_8) 		4 PHE A 516
LEU A 612
THR A 611
HIS A 615
 None
 0.96A 1azmA-4rg6A:
undetectable		 1azmA-4rg6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uht TRANSCRIPTIONAL
REGULATORY PROTEIN
CPXR

(Escherichia
coli) 		PF00486
(Trans_reg_C) 		4 PHE A 218
HIS A 200
LEU A 157
THR A 158
 None
 0.80A 1azmA-4uhtA:
undetectable		 1azmA-4uhtA:
16.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 HIS A 112
HIS A 114
HIS A 131
LEU A 197
THR A 198
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.35A 1azmA-4uovA:
30.5		 1azmA-4uovA:
36.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		4 HIS B 942
HIS B 937
HIS B 744
THR B 732
 ZN  B1101 (-3.2A)
ZN  B1101 (-3.2A)
None
None
 0.81A 1azmA-4wwxB:
undetectable		 1azmA-4wwxB:
16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
HIS A  91
HIS A 108
LEU A 173
THR A 174
TRP A 184
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
None
 0.26A 1azmA-4x5sA:
28.6		 1azmA-4x5sA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		6 HIS A 110
HIS A 112
HIS A 129
LEU A 190
THR A 191
TRP A 201
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 ( 3.1A)
None
ZN  A 301 (-4.3A)
None
 0.49A 1azmA-4xfwA:
25.6		 1azmA-4xfwA:
29.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 160
HIS A 162
HIS A 179
LEU A 253
THR A 254
TRP A 264
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
None
 0.30A 1azmA-4xixA:
25.7		 1azmA-4xixA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 HIS A 165
HIS A 167
HIS A 184
LEU A 251
THR A 252
TRP A 262
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.1A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
None
 0.31A 1azmA-4xz5A:
29.3		 1azmA-4xz5A:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zon VERRUCULOGEN
SYNTHASE

(Aspergillus
fumigatus) 		PF05721
(PhyH) 		4 PHE A 159
HIS A 129
HIS A 205
LEU A 222
 None
FE2  A 402 ( 3.6A)
FE2  A 402 (-3.6A)
None
 0.93A 1azmA-4zonA:
undetectable		 1azmA-4zonA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 157
HIS A 125
HIS A 120
HIS A 302
 ZN  A 401 ( 3.2A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 3.3A)
ZN  A 402 (-3.5A)
 1.01A 1azmA-4zyoA:
undetectable		 1azmA-4zyoA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 157
HIS A 161
HIS A 125
HIS A 298
 ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.03A 1azmA-4zyoA:
undetectable		 1azmA-4zyoA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 4 HIS A  95
HIS A 157
HIS A  97
HIS A 215
 ZN  A2001 ( 3.4A)
ZN  A2001 ( 3.3A)
ZN  A2001 ( 3.0A)
ZN  A2002 ( 3.0A)
 1.04A 1azmA-5b3rA:
undetectable		 1azmA-5b3rA:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
None
 0.18A 1azmA-5cjfA:
35.3		 1azmA-5cjfA:
34.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e57 TRANSCRIPTION
REGULATOR AMTR

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N) 		4 LEU A  33
THR A  36
HIS A  37
TRP A 114
 None
 0.87A 1azmA-5e57A:
undetectable		 1azmA-5e57A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 PHE A 187
HIS A 151
LEU A 256
THR A 257
TRP A 267
 None
 0.67A 1azmA-5e5uA:
32.8		 1azmA-5e5uA:
29.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 HIS X  93
HIS X  95
HIS X 118
LEU X 196
THR X 197
TRP X 207
 ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
ZN  X 301 (-3.1A)
None
ZN  X 301 ( 4.4A)
None
 0.28A 1azmA-5eztX:
40.9		 1azmA-5eztX:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		4 HIS X 118
HIS X  93
HIS X  95
THR X 198
 ZN  X 301 (-3.1A)
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
 1.03A 1azmA-5eztX:
40.9		 1azmA-5eztX:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		4 PHE X 129
HIS X  95
THR X 197
TRP X 207
 None
ZN  X 301 (-3.2A)
ZN  X 301 ( 4.4A)
None
 0.75A 1azmA-5eztX:
40.9		 1azmA-5eztX:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyj GP120 ENV ECTODOMAIN
GP41 ENV ECTODOMAIN

(Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF00517
(GP41) 		4 HIS G  72
HIS B 564
THR G  63
HIS G  66
 None
 1.05A 1azmA-5fyjG:
undetectable		 1azmA-5fyjG:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		6 HIS A  96
HIS A  98
HIS A 115
LEU A 181
THR A 182
TRP A 192
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
 0.42A 1azmA-5hpjA:
28.0		 1azmA-5hpjA:
31.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
HIS A  98
LEU A 181
THR A 183
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
 1.07A 1azmA-5hpjA:
28.0		 1azmA-5hpjA:
31.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		4 PHE A 197
HIS A 204
HIS A 231
HIS A 208
 None
ZN  A 302 ( 3.4A)
ZN  A 302 (-3.1A)
HQE  A 303 ( 3.0A)
 0.94A 1azmA-5i3aA:
undetectable		 1azmA-5i3aA:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
None
 0.32A 1azmA-5jn9A:
30.9		 1azmA-5jn9A:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A  96
LEU A 198
THR A 200
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
 1.05A 1azmA-5jn9A:
30.9		 1azmA-5jn9A:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 PHE A 362
HIS A 377
HIS A 404
HIS A 381
 None
ZN  A 511 ( 3.2A)
ZN  A 511 (-3.1A)
ZN  A 511 ( 3.3A)
 0.94A 1azmA-5m8tA:
undetectable		 1azmA-5m8tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 PHE A 557
HIS A 255
LEU A 236
HIS A 224
 None
 1.06A 1azmA-5xqoA:
undetectable		 1azmA-5xqoA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 4 HIS A 942
HIS A 937
HIS A 744
THR A 732
 ZN  A1101 (-3.3A)
ZN  A1101 (-3.4A)
None
None
 0.80A 1azmA-6cg0A:
undetectable		 1azmA-6cg0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 6 HIS A 117
HIS A 119
HIS A 136
LEU A 201
THR A 202
TRP A 212
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 301 (-4.4A)
None
 0.23A 1azmA-6ekiA:
29.5		 1azmA-6ekiA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
None
 0.40A 1azmA-6fe1A:
32.3		 1azmA-6fe1A:
15.83