SIMILAR PATTERNS OF AMINO ACIDS FOR 1AX9_A_EDRA999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 GLU A 193
SER A 194
PHE A 324
HIS A 435
 None
 0.64A 1ax9A-1aqlA:
48.2		 1ax9A-1aqlA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 GLY A 107
GLU A 193
PHE A 324
HIS A 435
 None
 0.62A 1ax9A-1aqlA:
48.2		 1ax9A-1aqlA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A 121
GLU A 202
SER A 203
PHE A 295
HIS A 447
 None
 1.17A 1ax9A-1b41A:
59.6		 1ax9A-1b41A:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		6 GLY A 122
TYR A 124
GLU A 202
SER A 203
PHE A 338
HIS A 447
 None
 1.22A 1ax9A-1b41A:
59.6		 1ax9A-1b41A:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		7 TRP A  86
GLY A 121
TYR A 124
GLU A 202
SER A 203
PHE A 338
HIS A 447
 None
 0.63A 1ax9A-1b41A:
59.6		 1ax9A-1b41A:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 GLY A 121
GLU A 202
SER A 203
PHE A 295
HIS A 447
 None
 1.21A 1ax9A-1c2oA:
59.7		 1ax9A-1c2oA:
58.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 GLY A 122
TYR A 124
SER A 203
PHE A 338
HIS A 447
 None
 1.34A 1ax9A-1c2oA:
59.7		 1ax9A-1c2oA:
58.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		4 TRP A  86
GLY A 120
GLU A 202
HIS A 447
 None
 0.93A 1ax9A-1c2oA:
59.7		 1ax9A-1c2oA:
58.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		7 TRP A  86
GLY A 121
TYR A 124
GLU A 202
SER A 203
PHE A 338
HIS A 447
 None
 0.68A 1ax9A-1c2oA:
59.7		 1ax9A-1c2oA:
58.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		5 GLY A 106
GLU A 188
SER A 189
PHE A 314
HIS A 399
 None
 0.86A 1ax9A-1c7jA:
44.3		 1ax9A-1c7jA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 GLY A 123
GLU A 208
SER A 209
PHE A 345
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.4A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.8A)
 0.66A 1ax9A-1cleA:
42.3		 1ax9A-1cleA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		4 GLY A 124
SER A 209
PHE A 345
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.8A)
 0.83A 1ax9A-1cleA:
42.3		 1ax9A-1cleA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		4 GLU A 208
SER A 209
PHE A 344
HIS A 449
 None
 1.00A 1ax9A-1crlA:
41.0		 1ax9A-1crlA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLU A 208
SER A 209
PHE A 345
HIS A 449
 None
 0.64A 1ax9A-1crlA:
41.0		 1ax9A-1crlA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		4 GLY A 124
SER A 209
PHE A 345
HIS A 449
 None
 0.84A 1ax9A-1crlA:
41.0		 1ax9A-1crlA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		4 GLY A 239
GLU A 235
PHE A 362
HIS A 360
 None
 0.90A 1ax9A-1f8rA:
undetectable		 1ax9A-1f8rA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 GLY A 119
TYR A 121
SER A 200
PHE A 331
HIS A 440
 EMM  A1999 (-3.5A)
None
EMM  A1999 ( 1.4A)
EMM  A1999 (-4.7A)
EMM  A1999 ( 3.8A)
 1.38A 1ax9A-1gqrA:
71.1		 1ax9A-1gqrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		6 TRP A  84
GLU A 199
SER A 200
PHE A 330
PHE A 331
HIS A 440
 SAF  A1998 (-3.8A)
SAF  A1998 (-3.5A)
EMM  A1999 ( 1.4A)
SAF  A1998 (-3.1A)
EMM  A1999 (-4.7A)
EMM  A1999 ( 3.8A)
 1.16A 1ax9A-1gqrA:
71.1		 1ax9A-1gqrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		7 TRP A  84
GLY A 118
TYR A 121
GLU A 199
SER A 200
PHE A 331
HIS A 440
 SAF  A1998 (-3.8A)
SAF  A1998 ( 3.5A)
None
SAF  A1998 (-3.5A)
EMM  A1999 ( 1.4A)
EMM  A1999 (-4.7A)
EMM  A1999 ( 3.8A)
 0.79A 1ax9A-1gqrA:
71.1		 1ax9A-1gqrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLU A 208
SER A 209
PHE A 345
HIS A 449
 None
 0.77A 1ax9A-1gz7A:
41.6		 1ax9A-1gz7A:
30.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 124
GLU A 208
SER A 209
PHE A 345
HIS A 449
 None
 0.91A 1ax9A-1gz7A:
41.6		 1ax9A-1gz7A:
30.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		4 GLY A 127
SER A 202
PHE A 259
HIS A 338
 None
 1.01A 1ax9A-1jkmA:
19.3		 1ax9A-1jkmA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A 107
GLU A 193
SER A 194
PHE A 324
HIS A 435
 None
 0.72A 1ax9A-1jmyA:
49.2		 1ax9A-1jmyA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		4 GLY A 142
GLU A 220
SER A 221
HIS A 467
 None
 0.86A 1ax9A-1k4yA:
51.3		 1ax9A-1k4yA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 GLY A 151
GLU A 237
PHE A 371
HIS A 480
 SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.96A 1ax9A-1qonA:
55.7		 1ax9A-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 TRP A  83
GLY A 149
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
SO4  A 593 ( 4.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 1.01A 1ax9A-1qonA:
55.7		 1ax9A-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 TRP A  83
GLY A 150
GLU A 237
PHE A 371
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
I40  A 997 (-4.9A)
SO4  A 593 (-4.1A)
 0.39A 1ax9A-1qonA:
55.7		 1ax9A-1qonA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 TRP A  83
GLY A 150
GLU A 237
SER A 238
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.1A)
 0.57A 1ax9A-1qonA:
55.7		 1ax9A-1qonA:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		4 GLY A 238
GLU A 235
PHE A 362
HIS A 360
 None
 0.95A 1ax9A-1tdkA:
undetectable		 1ax9A-1tdkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		4 GLY A 239
GLU A 235
PHE A 362
HIS A 360
 None
 0.85A 1ax9A-1tdkA:
undetectable		 1ax9A-1tdkA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 GLU A 216
SER A 217
PHE A 358
HIS A 463
 None
 0.64A 1ax9A-1thgA:
37.3		 1ax9A-1thgA:
31.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 GLY A 127
SER A 210
PHE A 342
HIS A 440
 EDO  A1902 (-3.6A)
EDO  A1902 (-2.4A)
EDO  A1902 (-4.3A)
EDO  A1902 ( 4.9A)
 0.84A 1ax9A-1ukcA:
38.6		 1ax9A-1ukcA:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		4 TRP A 684
GLY A 595
SER A 616
PHE A 487
 None
 0.80A 1ax9A-1x9sA:
undetectable		 1ax9A-1x9sA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		4 GLY A 315
PHE A 412
PHE A 413
HIS A 409
 None
None
None
9CR  A 201 (-4.8A)
 0.93A 1ax9A-1xiuA:
undetectable		 1ax9A-1xiuA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eom ZINC FINGER PROTEIN
95 HOMOLOG

(Homo sapiens) 		no annotation 4 GLY A  19
PHE A  28
PHE A  22
HIS A  31
 None
None
None
ZN  A 201 ( 3.0A)
 0.96A 1ax9A-2eomA:
undetectable		 1ax9A-2eomA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 GLY A 146
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 0.74A 1ax9A-2fj0A:
49.2		 1ax9A-2fj0A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 378
GLU A 351
PHE A 231
HIS A 397
 None
 0.85A 1ax9A-2ibuA:
undetectable		 1ax9A-2ibuA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 379
GLU A 351
PHE A 231
HIS A 397
 None
 0.86A 1ax9A-2ibuA:
undetectable		 1ax9A-2ibuA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nab ZINC FINGER PROTEIN
496

(Mus musculus) 		no annotation 4 GLY A  18
PHE A  27
PHE A  21
HIS A  30
 None
None
None
ZN  A 101 (-2.9A)
 0.95A 1ax9A-2nabA:
undetectable		 1ax9A-2nabA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 GLY A  92
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.5A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.87A 1ax9A-2o7rA:
18.5		 1ax9A-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 GLY A  93
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.6A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.93A 1ax9A-2o7rA:
18.5		 1ax9A-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE

(Shewanella
oneidensis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 GLY A  28
GLU A 134
SER A 132
HIS A  25
 None
 0.91A 1ax9A-2oasA:
undetectable		 1ax9A-2oasA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 TRP A 152
TYR A  25
SER A 232
HIS A  83
 None
None
FE  A 501 ( 3.8A)
None
 0.82A 1ax9A-2ohhA:
undetectable		 1ax9A-2ohhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 GLY B1948
GLU B1844
PHE B1883
HIS B1848
 None
 0.95A 1ax9A-2r7eB:
undetectable		 1ax9A-2r7eB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		4 GLY A 134
PHE A 184
PHE A 169
HIS A 155
 None
 0.97A 1ax9A-2rmpA:
undetectable		 1ax9A-2rmpA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 GLY A 238
SER A 242
PHE A 133
PHE A 134
 None
 0.82A 1ax9A-2uw2A:
undetectable		 1ax9A-2uw2A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 GLY A 333
GLU A 378
PHE A 316
HIS A 327
 None
 0.98A 1ax9A-2wzsA:
undetectable		 1ax9A-2wzsA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 GLY A 397
TYR A 260
PHE A  36
PHE A  81
 None
 0.95A 1ax9A-2yevA:
3.2		 1ax9A-2yevA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 156
GLU A 185
SER A 331
PHE A 258
 HC4  A 400 (-3.6A)
None
HC4  A 400 ( 4.4A)
HC4  A 400 ( 3.9A)
 0.99A 1ax9A-3a5rA:
undetectable		 1ax9A-3a5rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 GLY A  79
SER A 150
PHE A 197
HIS A 273
 DEP  A 304 (-3.6A)
DEP  A 304 (-1.5A)
None
DEP  A 304 (-4.1A)
 0.86A 1ax9A-3ailA:
18.1		 1ax9A-3ailA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		4 GLY A  78
GLU A 130
SER A 132
HIS A  81
 None
None
None
GOL  A 302 (-3.9A)
 0.96A 1ax9A-3bczA:
undetectable		 1ax9A-3bczA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 GLY A 313
GLU A 242
SER A 263
PHE A 353
 None
 0.82A 1ax9A-3be7A:
undetectable		 1ax9A-3be7A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 GLY A 313
GLU A 242
SER A 263
PHE A 353
 None
 0.96A 1ax9A-3be7A:
undetectable		 1ax9A-3be7A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 GLY A 341
PHE A 438
PHE A 439
HIS A 435
 None
None
None
9CR  A7223 (-4.3A)
 1.00A 1ax9A-3dzuA:
undetectable		 1ax9A-3dzuA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  67
GLU A  96
PHE A 153
HIS A  95
 None
CD  A 501 (-3.5A)
None
CD  A 501 (-3.4A)
 0.96A 1ax9A-3ip1A:
undetectable		 1ax9A-3ip1A:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A1142
GLU A1220
SER A1221
HIS A1468
 WW2  A 193 (-3.4A)
WW2  A 193 ( 4.2A)
WW2  A 193 (-1.4A)
None
 0.67A 1ax9A-3k9bA:
49.4		 1ax9A-3k9bA:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 GLY A 239
GLU A 235
PHE A 362
HIS A 360
 None
 0.99A 1ax9A-3kveA:
undetectable		 1ax9A-3kveA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		4 GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 0.97A 1ax9A-3nwoA:
13.8		 1ax9A-3nwoA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 293
SER A 267
PHE A  51
HIS A  55
 DAL  A2472 ( 4.5A)
None
ALA  A2473 ( 4.6A)
None
 0.88A 1ax9A-3q4dA:
2.2		 1ax9A-3q4dA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9x ASCH DOMAIN

(Vibrio cholerae) 		PF04266
(ASCH) 		4 GLU A 109
PHE A 126
PHE A 127
HIS A 123
 None
 0.99A 1ax9A-3s9xA:
undetectable		 1ax9A-3s9xA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 GLY A 238
SER A 242
PHE A 133
PHE A 134
 None
 0.90A 1ax9A-3vpoA:
undetectable		 1ax9A-3vpoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmr PROLINE
IMINOPEPTIDASE

(Streptomyces
halstedii) 		PF00561
(Abhydrolase_1) 		4 GLY A  39
TYR A 211
SER A 110
HIS A 277
 None
 0.88A 1ax9A-3wmrA:
12.9		 1ax9A-3wmrA:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 134
GLU A 219
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
None
 0.69A 1ax9A-4be9A:
43.6		 1ax9A-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.87A 1ax9A-4be9A:
43.6		 1ax9A-4be9A:
32.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 345
GLU A 318
PHE A 199
HIS A 364
 None
 0.96A 1ax9A-4c2kA:
undetectable		 1ax9A-4c2kA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 346
GLU A 318
PHE A 199
HIS A 364
 None
 0.93A 1ax9A-4c2kA:
undetectable		 1ax9A-4c2kA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c89 ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 GLY A 107
TYR A 110
SER A 174
HIS A 313
 None
 0.89A 1ax9A-4c89A:
15.3		 1ax9A-4c89A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmy FERRITIN

(Chlorobaculum
tepidum) 		PF00210
(Ferritin) 		4 GLU A 130
PHE A  43
PHE A  42
HIS A  46
 FE  A1165 (-3.0A)
None
None
None
 0.98A 1ax9A-4cmyA:
undetectable		 1ax9A-4cmyA:
16.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		4 GLY A 136
GLU A 217
SER A 218
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
 0.75A 1ax9A-4fnmA:
38.9		 1ax9A-4fnmA:
30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 493
PHE A 328
PHE A 327
HIS A 331
 None
 0.98A 1ax9A-4fysA:
undetectable		 1ax9A-4fysA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1g NUCLEOCAPSID

(Leanyer virus) 		PF00952
(Bunya_nucleocap) 		4 GLY A 149
PHE A  46
PHE A  45
HIS A  49
 None
None
None
U  E   8 ( 4.0A)
 0.99A 1ax9A-4j1gA:
undetectable		 1ax9A-4j1gA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		4 GLY A  80
SER A 151
PHE A 197
HIS A 274
 None
 0.85A 1ax9A-4p9nA:
18.1		 1ax9A-4p9nA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 GLY A 119
TYR A 121
SER A 200
PHE A 331
HIS A 440
 None
 1.24A 1ax9A-4qwwA:
62.2		 1ax9A-4qwwA:
65.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		7 TRP A  84
GLY A 118
TYR A 121
GLU A 199
SER A 200
PHE A 331
HIS A 440
 None
 0.71A 1ax9A-4qwwA:
62.2		 1ax9A-4qwwA:
65.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 163
GLU A 192
SER A 338
PHE A 265
 None
 0.96A 1ax9A-4wumA:
undetectable		 1ax9A-4wumA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		6 TRP A  82
GLY A 116
GLU A 197
SER A 198
PHE A 329
HIS A 438
 40V  A1001 (-3.3A)
40V  A1001 (-3.2A)
40V  A1001 (-3.2A)
40V  A1001 (-3.1A)
40V  A1001 (-4.0A)
40V  A1001 (-3.6A)
 0.65A 1ax9A-4xiiA:
61.8		 1ax9A-4xiiA:
52.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 GLY A  87
SER A 159
PHE A 207
HIS A 283
 None
 0.84A 1ax9A-4ypvA:
17.7		 1ax9A-4ypvA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztb PROTEASE NSP2

(Chikungunya
virus) 		PF01707
(Peptidase_C9) 		4 GLY A 240
SER A 242
PHE A 296
PHE A 275
 None
 0.95A 1ax9A-4ztbA:
undetectable		 1ax9A-4ztbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 4 GLU B 176
PHE B 479
PHE B 478
HIS B 483
 None
 0.82A 1ax9A-5cyrB:
undetectable		 1ax9A-5cyrB:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 GLY A 125
GLU A 203
SER A 204
HIS A 449
 None
 0.68A 1ax9A-5fv4A:
51.6		 1ax9A-5fv4A:
37.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		4 GLY A 387
GLU A 219
PHE A 245
HIS A 248
 A  C   1 ( 3.7A)
None
A  C   2 ( 4.2A)
None
 0.87A 1ax9A-5habA:
undetectable		 1ax9A-5habA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		4 GLY A  84
SER A 156
PHE A 203
HIS A 281
 None
 0.71A 1ax9A-5l2pA:
17.1		 1ax9A-5l2pA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 GLY A 258
SER A 262
PHE A 315
PHE A 319
 None
 1.00A 1ax9A-5nfhA:
undetectable		 1ax9A-5nfhA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		4 GLY A 238
GLU A 235
PHE A 362
HIS A 360
 None
 0.96A 1ax9A-5ts5A:
undetectable		 1ax9A-5ts5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		4 GLY A 239
GLU A 235
PHE A 362
HIS A 360
 None
 0.92A 1ax9A-5ts5A:
undetectable		 1ax9A-5ts5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases) 		4 GLY D 139
PHE D 232
PHE D 233
HIS D 229
 None
 0.89A 1ax9A-5xfaD:
undetectable		 1ax9A-5xfaD:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfo PHD FINGER PROTEIN 1

(Homo sapiens) 		PF00628
(PHD) 		4 GLY A 192
TYR A 169
PHE A 211
HIS A 212
 None
None
None
ZN  A 403 (-3.2A)
 0.96A 1ax9A-5xfoA:
2.0		 1ax9A-5xfoA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2

(Homo sapiens) 		PF00628
(PHD) 		4 GLY A 207
TYR A 184
PHE A 226
HIS A 227
 None
None
None
ZN  A 404 (-3.2A)
 1.00A 1ax9A-5xfrA:
undetectable		 1ax9A-5xfrA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 TRP A 245
GLY A 278
GLU A 359
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.3A)
SEB  A 360 ( 4.2A)
 0.93A 1ax9A-5ydjA:
60.2		 1ax9A-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 6 TRP A 245
GLY A 279
TYR A 282
GLU A 359
PHE A 490
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
SEB  A 360 ( 4.2A)
 0.37A 1ax9A-5ydjA:
60.2		 1ax9A-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypt STILBENECARBOXYLATE
SYNTHASE 1

(Marchantia
polymorpha) 		no annotation 4 GLY A 165
GLU A 194
SER A 340
PHE A 267
 None
 0.96A 1ax9A-5yptA:
undetectable		 1ax9A-5yptA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 4 GLY A 257
GLU A 254
PHE A 379
HIS A 377
 None
 0.95A 1ax9A-5z2gA:
undetectable		 1ax9A-5z2gA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 4 GLY A 258
GLU A 254
PHE A 379
HIS A 377
 None
 0.92A 1ax9A-5z2gA:
undetectable		 1ax9A-5z2gA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 TRP A 245
GLY A 278
PHE A 490
HIS A 600
 None
 0.99A 1ax9A-6arxA:
59.3		 1ax9A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 6 TRP A 245
GLY A 279
TYR A 282
GLU A 359
PHE A 490
HIS A 600
 None
 0.45A 1ax9A-6arxA:
59.3		 1ax9A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 6 TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
HIS A 600
 None
 0.67A 1ax9A-6arxA:
59.3		 1ax9A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 4 GLY A 341
GLU A 314
PHE A 196
HIS A 360
 None
 0.90A 1ax9A-6bj9A:
undetectable		 1ax9A-6bj9A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 4 GLY A 342
GLU A 314
PHE A 196
HIS A 360
 None
 0.91A 1ax9A-6bj9A:
undetectable		 1ax9A-6bj9A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 4 GLY A  91
TYR A 320
SER A 169
HIS A 421
 None
 1.00A 1ax9A-6g21A:
12.5		 1ax9A-6g21A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 TRP A   6
GLY A 779
TYR A 794
PHE A  15
 None
 1.01A 1ax9A-6gh2A:
undetectable		 1ax9A-6gh2A:
8.59