SIMILAR PATTERNS OF AMINO ACIDS FOR 1AV2_D_DVAD8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 VAL A 240
VAL A 236
TRP A 391
 None
 0.89A 1av2C-1clwA:
undetectable
1av2D-1clwA:
undetectable		 1av2C-1clwA:
2.32
1av2D-1clwA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwp EBULIN

(Sambucus ebulus) 		PF00652
(Ricin_B_lectin) 		3 VAL B 185
VAL B 171
TRP B 175
 None
 0.91A 1av2C-1hwpB:
undetectable
1av2D-1hwpB:
undetectable		 1av2C-1hwpB:
7.58
1av2D-1hwpB:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkf LEUKOCIDIN F SUBUNIT

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 VAL A  84
VAL A 166
TRP A 164
 None
 0.90A 1av2C-1lkfA:
undetectable
1av2D-1lkfA:
undetectable		 1av2C-1lkfA:
4.28
1av2D-1lkfA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		3 VAL A 464
VAL A 466
TRP A 313
 None
 0.72A 1av2C-1m1cA:
undetectable
1av2D-1m1cA:
undetectable		 1av2C-1m1cA:
1.76
1av2D-1m1cA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdu GELSOLIN PRECURSOR

(Homo sapiens) 		PF00626
(Gelsolin) 		3 VAL A  45
VAL A  22
TRP A  20
 None
 0.71A 1av2C-1mduA:
undetectable
1av2D-1mduA:
undetectable		 1av2C-1mduA:
7.87
1av2D-1mduA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 VAL A 225
VAL A  13
TRP A   1
 None
 0.89A 1av2C-1olpA:
undetectable
1av2D-1olpA:
undetectable		 1av2C-1olpA:
10.22
1av2D-1olpA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 VAL G  69
VAL G  46
TRP G  44
 None
 0.64A 1av2C-1rgiG:
undetectable
1av2D-1rgiG:
undetectable		 1av2C-1rgiG:
3.77
1av2D-1rgiG:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin)
PF01290
(Thymosin) 		3 VAL G  69
VAL G  46
TRP G  44
 None
 0.70A 1av2C-1t44G:
undetectable
1av2D-1t44G:
undetectable		 1av2C-1t44G:
10.14
1av2D-1t44G:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xte SERINE/THREONINE-PRO
TEIN KINASE SGK3

(Mus musculus) 		PF00787
(PX) 		3 VAL A  34
VAL A  10
TRP A  39
 None
 0.96A 1av2C-1xteA:
undetectable
1av2D-1xteA:
undetectable		 1av2C-1xteA:
8.04
1av2D-1xteA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B)
PF02461
(AMO) 		3 VAL B  91
VAL A 200
TRP B  87
 None
 0.82A 1av2C-1yewB:
undetectable
1av2D-1yewB:
undetectable		 1av2C-1yewB:
16.05
1av2D-1yewB:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		3 VAL A 276
VAL A 278
TRP A 309
 None
 0.95A 1av2C-1yleA:
undetectable
1av2D-1yleA:
undetectable		 1av2C-1yleA:
4.18
1av2D-1yleA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 VAL A 464
VAL A 474
TRP A 557
 None
 0.84A 1av2C-1yr2A:
undetectable
1av2D-1yr2A:
undetectable		 1av2C-1yr2A:
4.46
1av2D-1yr2A:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 VAL B 125
VAL B  38
TRP B 150
 None
 0.97A 1av2C-2amcB:
undetectable
1av2D-2amcB:
undetectable		 1av2C-2amcB:
2.41
1av2D-2amcB:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cop ACYL-COENZYME A
BINDING DOMAIN
CONTAINING 6

(Homo sapiens) 		PF00887
(ACBP) 		3 VAL A  43
VAL A  41
TRP A  65
 None
 0.87A 1av2C-2copA:
undetectable
1av2D-2copA:
undetectable		 1av2C-2copA:
13.43
1av2D-2copA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 VAL H  20
VAL H  83
TRP H  36
 None
 0.90A 1av2C-2d7tH:
undetectable
1av2D-2d7tH:
undetectable		 1av2C-2d7tH:
6.52
1av2D-2d7tH:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		3 VAL A 124
VAL A 186
TRP A 200
 None
 0.94A 1av2C-2depA:
undetectable
1av2D-2depA:
undetectable		 1av2C-2depA:
9.30
1av2D-2depA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK

(Mus musculus) 		PF00017
(SH2) 		3 VAL A  36
VAL A  49
TRP A  11
 None
 0.94A 1av2C-2eu0A:
undetectable
1av2D-2eu0A:
undetectable		 1av2C-2eu0A:
4.59
1av2D-2eu0A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		3 VAL A  88
VAL A 150
TRP A 166
 None
 0.93A 1av2C-2f8qA:
undetectable
1av2D-2f8qA:
undetectable		 1av2C-2f8qA:
3.78
1av2D-2f8qA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ff6 GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		3 VAL G  69
VAL G  46
TRP G  44
 None
 0.71A 1av2C-2ff6G:
undetectable
1av2D-2ff6G:
undetectable		 1av2C-2ff6G:
10.11
1av2D-2ff6G:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1

(Porphyromonas
gingivalis) 		PF00274
(Glycolytic) 		3 VAL A  98
VAL A 135
TRP A  92
 None
 0.90A 1av2C-2iqtA:
undetectable
1av2D-2iqtA:
undetectable		 1av2C-2iqtA:
4.12
1av2D-2iqtA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l1l EXPORTIN-1

(Homo sapiens) 		no annotation 3 VAL B 604
VAL B 602
TRP B 559
 None
 0.85A 1av2C-2l1lB:
undetectable
1av2D-2l1lB:
undetectable		 1av2C-2l1lB:
12.28
1av2D-2l1lB:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2

(Homo sapiens) 		PF08210
(APOBEC_N) 		3 VAL A 192
VAL A 187
TRP A 188
 None
 0.97A 1av2C-2nytA:
undetectable
1av2D-2nytA:
undetectable		 1av2C-2nytA:
6.90
1av2D-2nytA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		3 VAL A 187
VAL A 224
TRP A 222
 None
 0.85A 1av2C-2o0xA:
undetectable
1av2D-2o0xA:
undetectable		 1av2C-2o0xA:
3.19
1av2D-2o0xA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		3 VAL A 132
VAL A 164
TRP A 171
 SAH  A 301 (-3.8A)
None
None
 0.75A 1av2C-2oy0A:
undetectable
1av2D-2oy0A:
undetectable		 1av2C-2oy0A:
6.78
1av2D-2oy0A:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4q UPF0366 PROTEIN
C11ORF67

(Homo sapiens) 		PF04430
(DUF498) 		3 VAL A  57
VAL A 114
TRP A  29
 None
 0.94A 1av2C-2q4qA:
undetectable
1av2D-2q4qA:
undetectable		 1av2C-2q4qA:
8.41
1av2D-2q4qA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		3 VAL A 606
VAL A 656
TRP A 602
 None
 0.89A 1av2C-2qr7A:
undetectable
1av2D-2qr7A:
undetectable		 1av2C-2qr7A:
4.68
1av2D-2qr7A:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rso CHROMATIN-ASSOCIATED
PROTEIN SWI6

(Schizosaccharomyces
pombe) 		PF00385
(Chromo) 		3 VAL A  83
VAL A  86
TRP A 104
 None
 0.86A 1av2C-2rsoA:
undetectable
1av2D-2rsoA:
undetectable		 1av2C-2rsoA:
10.84
1av2D-2rsoA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		3 VAL A  98
VAL A 160
TRP A 172
 None
 0.84A 1av2C-2uwfA:
undetectable
1av2D-2uwfA:
undetectable		 1av2C-2uwfA:
3.53
1av2D-2uwfA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		3 VAL A 285
VAL A 281
TRP A 436
 None
 0.98A 1av2C-2v5iA:
undetectable
1av2D-2v5iA:
undetectable		 1av2C-2v5iA:
2.33
1av2D-2v5iA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		3 VAL A 308
VAL A 306
TRP A 334
 None
 0.97A 1av2C-2yocA:
undetectable
1av2D-2yocA:
undetectable		 1av2C-2yocA:
1.73
1av2D-2yocA:
1.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyb HYPOTHETICAL PROTEIN
TTHA1606

(Thermus
thermophilus) 		PF01784
(NIF3) 		3 VAL A 180
VAL A 166
TRP A 124
 None
 0.97A 1av2C-2yybA:
undetectable
1av2D-2yybA:
undetectable		 1av2C-2yybA:
5.61
1av2D-2yybA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5c PROTEIN YPL144W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		3 VAL A  42
VAL A 114
TRP A 116
 None
 0.81A 1av2C-2z5cA:
undetectable
1av2D-2z5cA:
undetectable		 1av2C-2z5cA:
7.94
1av2D-2z5cA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 VAL A  51
VAL A  49
TRP A  79
 None
 0.80A 1av2C-3c87A:
undetectable
1av2D-3c87A:
undetectable		 1av2C-3c87A:
3.61
1av2D-3c87A:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 VAL A 699
VAL A 742
TRP A 713
 None
 0.90A 1av2C-3dmkA:
undetectable
1av2D-3dmkA:
undetectable		 1av2C-3dmkA:
2.09
1av2D-3dmkA:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		3 VAL A 305
VAL A 308
TRP A 295
 None
 0.79A 1av2C-3e7gA:
undetectable
1av2D-3e7gA:
undetectable		 1av2C-3e7gA:
2.91
1av2D-3e7gA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 VAL A 132
VAL A 164
TRP A 171
 SAM  A4633 (-3.4A)
None
None
 0.89A 1av2C-3eluA:
undetectable
1av2D-3eluA:
undetectable		 1av2C-3eluA:
8.46
1av2D-3eluA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f65 CHAPERONE PROTEIN
FAEE

(Escherichia
coli) 		PF00345
(PapD_N) 		3 VAL A  82
VAL A  41
TRP A  84
 None
 0.89A 1av2C-3f65A:
undetectable
1av2D-3f65A:
undetectable		 1av2C-3f65A:
4.93
1av2D-3f65A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwq D-SERINE DEAMINASE

(Paraburkholderia
xenovorans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 VAL A 273
VAL A  71
TRP A  95
 None
 0.95A 1av2C-3gwqA:
undetectable
1av2D-3gwqA:
undetectable		 1av2C-3gwqA:
3.82
1av2D-3gwqA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		3 VAL A  41
VAL A 234
TRP A  43
 None
 0.65A 1av2C-3irvA:
undetectable
1av2D-3irvA:
undetectable		 1av2C-3irvA:
9.78
1av2D-3irvA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 VAL A 266
VAL A 262
TRP A 130
 None
 0.96A 1av2C-3jxfA:
undetectable
1av2D-3jxfA:
undetectable		 1av2C-3jxfA:
4.61
1av2D-3jxfA:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyg UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		PF01242
(PTPS) 		3 VAL A 132
VAL A 111
TRP A 103
 None
 0.97A 1av2C-3jygA:
undetectable
1av2D-3jygA:
undetectable		 1av2C-3jygA:
8.09
1av2D-3jygA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkj CD40 LIGAND

(Homo sapiens) 		PF00229
(TNF) 		3 VAL A 239
VAL A 237
TRP A 140
 None
 0.65A 1av2C-3lkjA:
undetectable
1av2D-3lkjA:
undetectable		 1av2C-3lkjA:
4.96
1av2D-3lkjA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lku UPF0363 PROTEIN
YOR164C

(Saccharomyces
cerevisiae) 		PF04190
(DUF410) 		3 VAL A  88
VAL A  82
TRP A 122
 None
 0.91A 1av2C-3lkuA:
undetectable
1av2D-3lkuA:
undetectable		 1av2C-3lkuA:
6.47
1av2D-3lkuA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		3 VAL A 132
VAL A 164
TRP A 171
 SFG  A 301 (-4.1A)
None
None
 0.72A 1av2C-3lkzA:
undetectable
1av2D-3lkzA:
undetectable		 1av2C-3lkzA:
4.30
1av2D-3lkzA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 VAL A  52
VAL A  50
TRP A  80
 None
 0.83A 1av2C-3mgaA:
undetectable
1av2D-3mgaA:
undetectable		 1av2C-3mgaA:
3.23
1av2D-3mgaA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 VAL A 256
VAL A 251
TRP A 253
 None
 0.96A 1av2C-3mjfA:
undetectable
1av2D-3mjfA:
undetectable		 1av2C-3mjfA:
3.80
1av2D-3mjfA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 3 VAL A 342
VAL A 352
TRP A 143
 None
 0.66A 1av2C-3nlcA:
undetectable
1av2D-3nlcA:
undetectable		 1av2C-3nlcA:
2.41
1av2D-3nlcA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 VAL A 351
VAL A 349
TRP A  28
 None
 0.61A 1av2C-3t8qA:
undetectable
1av2D-3t8qA:
undetectable		 1av2C-3t8qA:
8.14
1av2D-3t8qA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfz CYCLASE

(Streptomyces
sp. R1128) 		PF10604
(Polyketide_cyc2) 		3 VAL A  53
VAL A  37
TRP A  62
 None
None
CXS  A 171 (-4.4A)
 0.69A 1av2C-3tfzA:
undetectable
1av2D-3tfzA:
undetectable		 1av2C-3tfzA:
11.00
1av2D-3tfzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu5 GELSOLIN,PROTEIN
CORDON-BLEU,THYMOSIN
BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin) 		3 VAL B  45
VAL B  22
TRP B  20
 None
 0.73A 1av2C-3tu5B:
undetectable
1av2D-3tu5B:
undetectable		 1av2C-3tu5B:
4.65
1av2D-3tu5B:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		3 VAL A 166
VAL A 164
TRP A  64
 None
ADE  A 301 (-3.8A)
None
 0.92A 1av2C-3wazA:
undetectable
1av2D-3wazA:
undetectable		 1av2C-3wazA:
5.35
1av2D-3wazA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		3 VAL A 690
VAL A 685
TRP A 659
 None
 0.90A 1av2C-4av6A:
undetectable
1av2D-4av6A:
undetectable		 1av2C-4av6A:
3.69
1av2D-4av6A:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D

(Phanerochaete
chrysosporium) 		PF03443
(Glyco_hydro_61) 		3 VAL A  21
VAL A  19
TRP A  18
 None
 0.95A 1av2C-4b5qA:
undetectable
1av2D-4b5qA:
undetectable		 1av2C-4b5qA:
5.26
1av2D-4b5qA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A  54
VAL A  60
TRP A  58
 None
 0.73A 1av2C-4btmA:
undetectable
1av2D-4btmA:
undetectable		 1av2C-4btmA:
4.00
1av2D-4btmA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA

(Rattus
norvegicus) 		PF01239
(PPTA) 		3 VAL A 152
VAL A 158
TRP A 125
 None
 0.93A 1av2C-4gtvA:
undetectable
1av2D-4gtvA:
undetectable		 1av2C-4gtvA:
4.03
1av2D-4gtvA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu FAB 8M2 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H  20
VAL H  82
TRP H  36
 None
 0.80A 1av2C-4hfuH:
undetectable
1av2D-4hfuH:
undetectable		 1av2C-4hfuH:
8.85
1av2D-4hfuH:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 VAL A 260
VAL A 348
TRP A 358
 None
 0.85A 1av2C-4hjlA:
undetectable
1av2D-4hjlA:
undetectable		 1av2C-4hjlA:
4.48
1av2D-4hjlA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igv KIROLA

(Actinidia
deliciosa) 		PF00407
(Bet_v_1) 		3 VAL A 103
VAL A 105
TRP A 116
 None
 0.82A 1av2C-4igvA:
undetectable
1av2D-4igvA:
undetectable		 1av2C-4igvA:
8.08
1av2D-4igvA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE

(Cupriavidus
metallidurans) 		PF00378
(ECH_1) 		3 VAL A  51
VAL A  49
TRP A  14
 None
 0.89A 1av2C-4jcsA:
undetectable
1av2D-4jcsA:
undetectable		 1av2C-4jcsA:
6.92
1av2D-4jcsA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 101
VAL H  34
TRP H 101
 None
 0.89A 1av2C-4k3dH:
undetectable
1av2D-4k3dH:
undetectable		 1av2C-4k3dH:
5.62
1av2D-4k3dH:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14

(Homo sapiens) 		PF00229
(TNF) 		3 VAL A 217
VAL A 215
TRP A 114
 None
 0.75A 1av2C-4kg8A:
undetectable
1av2D-4kg8A:
undetectable		 1av2C-4kg8A:
11.21
1av2D-4kg8A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf9 HEMIN DEGRADING
FACTOR

(Pseudomonas
aeruginosa) 		PF05171
(HemS) 		3 VAL A 305
VAL A 314
TRP A 202
 None
HEM  A 400 ( 4.9A)
None
 0.59A 1av2C-4mf9A:
undetectable
1av2D-4mf9A:
undetectable		 1av2C-4mf9A:
4.30
1av2D-4mf9A:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A  30
VAL A  36
TRP A  34
 None
 0.70A 1av2C-4nfnA:
undetectable
1av2D-4nfnA:
undetectable		 1av2C-4nfnA:
4.45
1av2D-4nfnA:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51

(Mus musculus) 		PF03281
(Mab-21) 		3 VAL A 262
VAL A 252
TRP A 337
 None
 0.85A 1av2C-4oahA:
undetectable
1av2D-4oahA:
undetectable		 1av2C-4oahA:
3.75
1av2D-4oahA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pau NITROGEN REGULATORY
PROTEIN A

(Staphylococcus
aureus) 		PF13185
(GAF_2) 		3 VAL A 116
VAL A 119
TRP A 111
 None
 0.88A 1av2C-4pauA:
undetectable
1av2D-4pauA:
undetectable		 1av2C-4pauA:
15.94
1av2D-4pauA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkh GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin)
PF03250
(Tropomodulin) 		3 VAL B  96
VAL B  73
TRP B  71
 None
 0.61A 1av2C-4pkhB:
undetectable
1av2D-4pkhB:
undetectable		 1av2C-4pkhB:
4.42
1av2D-4pkhB:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		3 VAL G  96
VAL G  73
TRP G  71
 None
 0.70A 1av2C-4pkiG:
undetectable
1av2D-4pkiG:
undetectable		 1av2C-4pkiG:
8.47
1av2D-4pkiG:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		3 VAL A  98
VAL A 160
TRP A 172
 None
 0.89A 1av2C-4pueA:
undetectable
1av2D-4pueA:
undetectable		 1av2C-4pueA:
3.28
1av2D-4pueA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7g LEUCOTOXIN LUKDV

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 VAL A 110
VAL A 192
TRP A 190
 None
 0.93A 1av2C-4q7gA:
undetectable
1av2D-4q7gA:
undetectable		 1av2C-4q7gA:
5.09
1av2D-4q7gA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 3 VAL A 438
VAL A 254
TRP A 403
 None
 0.96A 1av2C-4qnlA:
undetectable
1av2D-4qnlA:
undetectable		 1av2C-4qnlA:
4.29
1av2D-4qnlA:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY

(Bordetella
pertussis) 		PF11563
(Protoglobin) 		3 VAL A  76
VAL A  89
TRP A  72
 None
None
HEM  A 200 (-3.2A)
 0.89A 1av2C-4uiqA:
undetectable
1av2D-4uiqA:
undetectable		 1av2C-4uiqA:
15.69
1av2D-4uiqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		3 VAL A 269
VAL A 105
TRP A  96
 None
 0.87A 1av2C-4v1uA:
undetectable
1av2D-4v1uA:
undetectable		 1av2C-4v1uA:
2.94
1av2D-4v1uA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		3 VAL C 340
VAL C 335
TRP C 550
 None
 0.98A 1av2C-4yfaC:
undetectable
1av2D-4yfaC:
undetectable		 1av2C-4yfaC:
3.66
1av2D-4yfaC:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		3 VAL G  45
VAL G  22
TRP G  20
 None
 0.77A 1av2C-4z94G:
undetectable
1av2D-4z94G:
undetectable		 1av2C-4z94G:
4.68
1av2D-4z94G:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		3 VAL A 332
VAL A 360
TRP A 143
 None
 0.92A 1av2C-4zasA:
undetectable
1av2D-4zasA:
undetectable		 1av2C-4zasA:
3.59
1av2D-4zasA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cze PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		3 VAL B  81
VAL B  79
TRP B   6
 None
 0.89A 1av2C-5czeB:
undetectable
1av2D-5czeB:
undetectable		 1av2C-5czeB:
17.95
1av2D-5czeB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czf PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		3 VAL C  81
VAL C  79
TRP C   6
 None
 0.92A 1av2C-5czfC:
undetectable
1av2D-5czfC:
undetectable		 1av2C-5czfC:
14.29
1av2D-5czfC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmu NHEJ POLYMERASE

(Methanocella
paludicola) 		no annotation 3 VAL A 194
VAL A 196
TRP A 272
 None
 0.74A 1av2C-5dmuA:
undetectable
1av2D-5dmuA:
undetectable		 1av2C-5dmuA:
4.63
1av2D-5dmuA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8e IGA FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL B  20
VAL B  83
TRP B  36
 None
 0.86A 1av2C-5e8eB:
undetectable
1av2D-5e8eB:
undetectable		 1av2C-5e8eB:
5.39
1av2D-5e8eB:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 VAL L 104
VAL L  95
TRP H  48
 None
 0.94A 1av2C-5eorL:
undetectable
1av2D-5eorL:
undetectable		 1av2C-5eorL:
6.25
1av2D-5eorL:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		3 VAL A  39
VAL A 133
TRP A  16
 None
 0.84A 1av2C-5gqtA:
undetectable
1av2D-5gqtA:
undetectable		 1av2C-5gqtA:
2.86
1av2D-5gqtA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h83 HETEROYOHIMBINE
SYNTHASE HYS

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  76
VAL A  78
TRP A 149
 None
 0.86A 1av2C-5h83A:
undetectable
1av2D-5h83A:
undetectable		 1av2C-5h83A:
6.02
1av2D-5h83A:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijv BOVINE FAB E03 HEAVY
CHAIN

(Bos taurus) 		no annotation 3 VAL H 136
VAL H  34
TRP H 134
 None
 0.90A 1av2C-5ijvH:
undetectable
1av2D-5ijvH:
undetectable		 1av2C-5ijvH:
5.39
1av2D-5ijvH:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		3 VAL A 132
VAL A 164
TRP A 171
 SAM  A 311 (-3.7A)
None
None
 0.77A 1av2C-5ikmA:
undetectable
1av2D-5ikmA:
undetectable		 1av2C-5ikmA:
5.38
1av2D-5ikmA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 153
VAL H  34
TRP H 151
 None
 0.84A 1av2C-5iltH:
undetectable
1av2D-5iltH:
undetectable		 1av2C-5iltH:
6.45
1av2D-5iltH:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1

(Staphylococcus
aureus) 		no annotation 3 VAL B  86
VAL B 170
TRP B 168
 None
 0.98A 1av2C-5k59B:
undetectable
1av2D-5k59B:
undetectable		 1av2C-5k59B:
8.59
1av2D-5k59B:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 3 VAL D 113
VAL D 193
TRP D 191
 None
 0.72A 1av2C-5k59D:
undetectable
1av2D-5k59D:
undetectable		 1av2C-5k59D:
4.52
1av2D-5k59D:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kw9 IGA(VH)-IGG(CH)
HEAVY CHAIN FAB
FRAGMENT

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H  20
VAL H  83
TRP H  36
 None
 0.78A 1av2C-5kw9H:
undetectable
1av2D-5kw9H:
undetectable		 1av2C-5kw9H:
5.26
1av2D-5kw9H:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		3 VAL A  82
VAL A  91
TRP A  93
 None
 0.95A 1av2C-5l9sA:
undetectable
1av2D-5l9sA:
undetectable		 1av2C-5l9sA:
4.09
1av2D-5l9sA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 VAL A 133
VAL A 150
TRP A 152
 None
 0.90A 1av2C-5mdnA:
undetectable
1av2D-5mdnA:
undetectable		 1av2C-5mdnA:
1.80
1av2D-5mdnA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n07 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR NSRR

(Streptomyces
coelicolor) 		PF02082
(Rrf2) 		3 VAL A  75
VAL A  77
TRP A  79
 None
 0.88A 1av2C-5n07A:
undetectable
1av2D-5n07A:
undetectable		 1av2C-5n07A:
8.73
1av2D-5n07A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN
CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1;
Rosellinia
necatrix
quadrivirus 1) 		no annotation
no annotation 		3 VAL B 904
VAL A 893
TRP B 906
 None
 0.90A 1av2C-5nd1B:
undetectable
1av2D-5nd1B:
undetectable		 1av2C-5nd1B:
undetectable
1av2D-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 VAL A1151
VAL A1101
TRP A1153
 None
 0.97A 1av2C-5vadA:
undetectable
1av2D-5vadA:
undetectable		 1av2C-5vadA:
4.32
1av2D-5vadA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnm PHOTOSYSTEM II
REACTION CENTER
PROTEIN Z

(Pisum sativum) 		PF01737
(Ycf9) 		3 VAL Z  51
VAL Z   9
TRP Z  47
 None
 0.83A 1av2C-5xnmZ:
undetectable
1av2D-5xnmZ:
undetectable		 1av2C-5xnmZ:
20.37
1av2D-5xnmZ:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 VAL C  55
VAL C  51
TRP C  15
 None
 0.83A 1av2C-5xynC:
undetectable
1av2D-5xynC:
undetectable		 1av2C-5xynC:
9.76
1av2D-5xynC:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 3 VAL A 396
VAL A 406
TRP A 408
 None
 0.87A 1av2C-6cmzA:
undetectable
1av2D-6cmzA:
undetectable		 1av2C-6cmzA:
undetectable
1av2D-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 3 VAL B  63
VAL B  61
TRP B  48
 None
 0.91A 1av2C-6cxhB:
undetectable
1av2D-6cxhB:
undetectable		 1av2C-6cxhB:
undetectable
1av2D-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 3 VAL A  93
VAL A 155
TRP A 167
 None
 0.84A 1av2C-6fheA:
undetectable
1av2D-6fheA:
undetectable		 1av2C-6fheA:
undetectable
1av2D-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 3 VAL A  98
VAL A 160
TRP A 174
 None
 0.88A 1av2C-6fhfA:
undetectable
1av2D-6fhfA:
undetectable		 1av2C-6fhfA:
undetectable
1av2D-6fhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 3 VAL A 706
VAL A 665
TRP A 702
 None
 0.78A 1av2C-6fuyA:
undetectable
1av2D-6fuyA:
undetectable		 1av2C-6fuyA:
undetectable
1av2D-6fuyA:
undetectable