SIMILAR PATTERNS OF AMINO ACIDS FOR 1AV2_C_DVAC6_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3b | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermotogamaritima) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | ALA A 149VAL A 151TRP A 154 | None | 0.86A | 1av2C-1b3bA:undetectable1av2D-1b3bA:undetectable | 1av2C-1b3bA:6.501av2D-1b3bA:6.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ehy | PROTEIN (SOLUBLEEPOXIDE HYDROLASE) (Agrobacteriumtumefaciens) |
PF00561(Abhydrolase_1) | 3 | ALA A 110VAL A 104TRP A 45 | None | 0.85A | 1av2C-1ehyA:undetectable1av2D-1ehyA:undetectable | 1av2C-1ehyA:5.651av2D-1ehyA:5.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gll | GLYCEROL KINASE (Escherichiacoli) |
no annotation | 3 | ALA Y 100VAL Y 88TRP Y 89 | None | 0.85A | 1av2C-1gllY:undetectable1av2D-1gllY:undetectable | 1av2C-1gllY:3.641av2D-1gllY:3.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5u | ARCHEASE, POSSIBLECHAPERONE (Thermotogamaritima) |
PF01951(Archease) | 3 | ALA A 62VAL A 67TRP A 70 | None | 0.81A | 1av2C-1j5uA:undetectable1av2D-1j5uA:undetectable | 1av2C-1j5uA:5.881av2D-1j5uA:5.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jyh | DNA GYRASEINHIBITORY PROTEIN (Escherichiacoli) |
PF06445(GyrI-like) | 3 | ALA A 49VAL A 69TRP A 47 | None | 0.83A | 1av2C-1jyhA:undetectable1av2D-1jyhA:undetectable | 1av2C-1jyhA:9.451av2D-1jyhA:9.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nd4 | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE (Klebsiellapneumoniae) |
PF01636(APH) | 3 | ALA A 35VAL A 49TRP A 24 | None | 0.88A | 1av2C-1nd4A:undetectable1av2D-1nd4A:undetectable | 1av2C-1nd4A:5.861av2D-1nd4A:5.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r2k | MOLYBDENUM COFACTORBIOSYNTHESIS PROTEINB (Escherichiacoli) |
no annotation | 3 | ALA B 58VAL B 60TRP B 63 | None | 0.84A | 1av2C-1r2kB:undetectable1av2D-1r2kB:undetectable | 1av2C-1r2kB:6.591av2D-1r2kB:6.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rbl | RIBULOSE 1,5BISPHOSPHATECARBOXYLASE/OXYGENASE (LARGE CHAIN) (Synechococcuselongatus) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 3 | ALA A 15VAL A 17TRP A 66 | None | 0.76A | 1av2C-1rblA:undetectable1av2D-1rblA:undetectable | 1av2C-1rblA:4.081av2D-1rblA:4.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sfr | ANTIGEN 85-A (Mycobacteriumtuberculosis) |
PF00756(Esterase) | 3 | ALA A 129VAL A 123TRP A 51 | None | 0.73A | 1av2C-1sfrA:undetectable1av2D-1sfrA:undetectable | 1av2C-1sfrA:6.901av2D-1sfrA:6.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sfs | HYPOTHETICAL PROTEIN (Geobacillusstearothermophilus) |
PF08924(DUF1906) | 3 | ALA A 154VAL A 158TRP A 189 | None | 0.72A | 1av2C-1sfsA:undetectable1av2D-1sfsA:undetectable | 1av2C-1sfsA:7.591av2D-1sfsA:7.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wom | SIGMA FACTOR SIGBREGULATION PROTEINRSBQ (Bacillussubtilis) |
PF12697(Abhydrolase_6) | 3 | ALA A 99VAL A 93TRP A 34 | None | 0.79A | 1av2C-1womA:undetectable1av2D-1womA:undetectable | 1av2C-1womA:18.331av2D-1womA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xje | RIBONUCLEOTIDEREDUCTASE,B12-DEPENDENT (Thermotogamaritima) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC) | 3 | ALA A 49VAL A 44TRP A 41 | None | 0.64A | 1av2C-1xjeA:undetectable1av2D-1xjeA:undetectable | 1av2C-1xjeA:1.741av2D-1xjeA:1.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yhu | HEMOGLOBIN B1A CHAIN (Riftiapachyptila) |
PF00042(Globin) | 3 | ALA C 24VAL C 19TRP C 16 | None | 0.73A | 1av2C-1yhuC:undetectable1av2D-1yhuC:undetectable | 1av2C-1yhuC:5.971av2D-1yhuC:5.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z5z | HELICASE OF THESNF2/RAD54 FAMILY (Sulfolobussolfataricus) |
PF00271(Helicase_C) | 3 | ALA A 809VAL A 807TRP A 828 | None | 0.71A | 1av2C-1z5zA:undetectable1av2D-1z5zA:undetectable | 1av2C-1z5zA:3.821av2D-1z5zA:3.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ljr | GLUTATHIONES-TRANSFERASE (Homo sapiens) |
PF00043(GST_C)PF02798(GST_N) | 3 | ALA A 158VAL A 162TRP A 84 | None | 0.76A | 1av2C-2ljrA:undetectable1av2D-2ljrA:undetectable | 1av2C-2ljrA:5.671av2D-2ljrA:5.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nlx | XYLULOSE KINASE (Escherichiacoli) |
PF00370(FGGY_N)PF02782(FGGY_C) | 3 | ALA A 374VAL A 369TRP A 402 | None | 0.84A | 1av2C-2nlxA:undetectable1av2D-2nlxA:undetectable | 1av2C-2nlxA:10.341av2D-2nlxA:10.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o8p | 14-3-3 DOMAINCONTAINING PROTEIN (Cryptosporidiumparvum) |
PF00244(14-3-3) | 3 | ALA A 18VAL A 20TRP A 23 | None | 0.83A | 1av2C-2o8pA:undetectable1av2D-2o8pA:undetectable | 1av2C-2o8pA:5.811av2D-2o8pA:5.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oz8 | MLL7089 PROTEIN (Mesorhizobiumjaponicum) |
PF13378(MR_MLE_C) | 3 | ALA A 204VAL A 209TRP A 242 | None | 0.71A | 1av2C-2oz8A:undetectable1av2D-2oz8A:undetectable | 1av2C-2oz8A:4.781av2D-2oz8A:4.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p0n | HYPOTHETICAL PROTEINNMB1532 (Neisseriameningitidis) |
PF01814(Hemerythrin) | 3 | ALA A 111VAL A 106TRP A 103 | None | 0.87A | 1av2C-2p0nA:undetectable1av2D-2p0nA:undetectable | 1av2C-2p0nA:10.201av2D-2p0nA:10.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p9n | ACTIN-RELATEDPROTEIN 2/3 COMPLEXSUBUNIT 1B (Bos taurus) |
PF00400(WD40) | 3 | ALA C 76VAL C 78TRP C 104 | None | 0.75A | 1av2C-2p9nC:undetectable1av2D-2p9nC:undetectable | 1av2C-2p9nC:3.521av2D-2p9nC:3.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2psf | RENILLA-LUCIFERIN2-MONOOXYGENASE (Renillareniformis) |
PF00561(Abhydrolase_1) | 3 | ALA A 123VAL A 117TRP A 60 | None | 0.82A | 1av2C-2psfA:undetectable1av2D-2psfA:undetectable | 1av2C-2psfA:4.621av2D-2psfA:4.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qf7 | PYRUVATE CARBOXYLASEPROTEIN (Rhizobium etli) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF00682(HMGL-like)PF02436(PYC_OADA)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | ALA A 869VAL A 864TRP A 861 | None | 0.84A | 1av2C-2qf7A:undetectable1av2D-2qf7A:undetectable | 1av2C-2qf7A:2.251av2D-2qf7A:2.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vak | SIGMA A (Avianorthoreovirus) |
PF03084(Sigma_1_2) | 3 | ALA A 83VAL A 85TRP A 105 | None | 0.80A | 1av2C-2vakA:undetectable1av2D-2vakA:undetectable | 1av2C-2vakA:5.531av2D-2vakA:5.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x05 | EXO-BETA-D-GLUCOSAMINIDASE (Amycolatopsisorientalis) |
PF00703(Glyco_hydro_2)PF02837(Glyco_hydro_2_N) | 3 | ALA A 63VAL A 65TRP A 81 | None | 0.89A | 1av2C-2x05A:undetectable1av2D-2x05A:undetectable | 1av2C-2x05A:1.741av2D-2x05A:1.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayf | NITRIC OXIDEREDUCTASE (Geobacillusstearothermophilus) |
PF00115(COX1) | 3 | ALA A 626VAL A 624TRP A 621 | HEM A 802 (-3.5A)LOP A 810 (-4.9A)LOP A 810 (-3.6A) | 0.82A | 1av2C-3ayfA:undetectable1av2D-3ayfA:undetectable | 1av2C-3ayfA:3.171av2D-3ayfA:3.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b12 | FLUOROACETATEDEHALOGENASE (Burkholderiasp.) |
PF00561(Abhydrolase_1) | 3 | ALA A 104VAL A 126TRP A 255 | FAH A 501 (-3.5A)NoneNone | 0.82A | 1av2C-3b12A:undetectable1av2D-3b12A:undetectable | 1av2C-3b12A:4.661av2D-3b12A:4.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bex | TYPE IIIPANTOTHENATE KINASE (Thermotogamaritima) |
PF03309(Pan_kinase) | 3 | ALA A 104VAL A 59TRP A 84 | None | 0.83A | 1av2C-3bexA:undetectable1av2D-3bexA:undetectable | 1av2C-3bexA:15.151av2D-3bexA:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bn1 | PEROSAMINESYNTHETASE (Caulobactervibrioides) |
PF01041(DegT_DnrJ_EryC1) | 3 | ALA A 252VAL A 257TRP A 260 | None | 0.87A | 1av2C-3bn1A:undetectable1av2D-3bn1A:undetectable | 1av2C-3bn1A:5.711av2D-3bn1A:5.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bv6 | METAL-DEPENDENTHYDROLASE (Vibrio cholerae) |
PF13483(Lactamase_B_3) | 3 | ALA A 146VAL A 148TRP A 151 | None | 0.89A | 1av2C-3bv6A:undetectable1av2D-3bv6A:undetectable | 1av2C-3bv6A:6.071av2D-3bv6A:6.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3deg | GTP-BINDING PROTEINLEPA (Escherichiacoli) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF06421(LepA_C) | 3 | ALA C 234VAL C 259TRP C 257 | None | 0.80A | 1av2C-3degC:undetectable1av2D-3degC:undetectable | 1av2C-3degC:5.431av2D-3degC:5.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqn | GLUCAN1,3-BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF12708(Pectate_lyase_3) | 3 | ALA A 444VAL A 475TRP A 505 | None | 0.87A | 1av2C-3eqnA:undetectable1av2D-3eqnA:undetectable | 1av2C-3eqnA:2.741av2D-3eqnA:2.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewi | N-ACYLNEURAMINATECYTIDYLYLTRANSFERASE (Mus musculus) |
no annotation | 3 | ALA A 86VAL A 88TRP A 91 | None | 0.83A | 1av2C-3ewiA:undetectable1av2D-3ewiA:undetectable | 1av2C-3ewiA:12.501av2D-3ewiA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibz | PUTATIVE TELLURIUMRESISTANT LIKEPROTEIN TERD (Streptomycescoelicolor) |
PF02342(TerD) | 3 | ALA A 100VAL A 98TRP A 167 | None | 0.88A | 1av2C-3ibzA:undetectable1av2D-3ibzA:undetectable | 1av2C-3ibzA:6.551av2D-3ibzA:6.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ijl | MUCONATECYCLOISOMERASE (Bacteroidesthetaiotaomicron) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | ALA A 317VAL A 312TRP A 309 | None | 0.82A | 1av2C-3ijlA:undetectable1av2D-3ijlA:undetectable | 1av2C-3ijlA:8.021av2D-3ijlA:8.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k3d | PROTEINRV1364C/MT1410 (Mycobacteriumtuberculosis) |
PF08448(PAS_4) | 3 | ALA A 13VAL A 11TRP A 7 | None | 0.88A | 1av2C-3k3dA:undetectable1av2D-3k3dA:undetectable | 1av2C-3k3dA:13.581av2D-3k3dA:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9b | LIVERCARBOXYLESTERASE 1 (Homo sapiens) |
PF00135(COesterase) | 3 | ALA A1422VAL A1424TRP A1547 | None | 0.81A | 1av2C-3k9bA:undetectable1av2D-3k9bA:undetectable | 1av2C-3k9bA:5.881av2D-3k9bA:5.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfl | METHIONYL-TRNASYNTHETASE (Leishmaniamajor) |
PF09334(tRNA-synt_1g) | 3 | ALA A 695VAL A 698TRP A 596 | None | 0.86A | 1av2C-3kflA:undetectable1av2D-3kflA:undetectable | 1av2C-3kflA:4.381av2D-3kflA:4.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lv4 | GLYCOSIDE HYDROLASEYXIA (Bacilluslicheniformis) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 3 | ALA A 131VAL A 174TRP A 104 | None | 0.87A | 1av2C-3lv4A:undetectable1av2D-3lv4A:undetectable | 1av2C-3lv4A:2.911av2D-3lv4A:2.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppo | GLYCINEBETAINE/CARNITINE/CHOLINE-BINDINGPROTEIN (Bacillussubtilis) |
PF04069(OpuAC) | 3 | ALA A 216VAL A 168TRP A 172 | None | 0.81A | 1av2C-3ppoA:undetectable1av2D-3ppoA:undetectable | 1av2C-3ppoA:5.461av2D-3ppoA:5.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3prx | COBRA VENOM FACTOR (Naja kaouthia) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 3 | ALA B 791VAL B 578TRP B 757 | None | 0.88A | 1av2C-3prxB:undetectable1av2D-3prxB:undetectable | 1av2C-3prxB:1.671av2D-3prxB:1.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9c | ACETYLPOLYAMINEAMIDOHYDROLASE (Mycoplanaramosa) |
PF00850(Hist_deacetyl) | 3 | ALA A 215VAL A 194TRP A 258 | None | 0.86A | 1av2C-3q9cA:undetectable1av2D-3q9cA:undetectable | 1av2C-3q9cA:2.681av2D-3q9cA:2.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s51 | FANCONI ANEMIA GROUPI PROTEIN HOMOLOG (Mus musculus) |
PF14674(FANCI_S1-cap)PF14675(FANCI_S1)PF14676(FANCI_S2)PF14677(FANCI_S3)PF14678(FANCI_S4)PF14679(FANCI_HD1)PF14680(FANCI_HD2) | 3 | ALA A 196VAL A 198TRP A 169 | None | 0.80A | 1av2C-3s51A:undetectable1av2D-3s51A:undetectable | 1av2C-3s51A:1.351av2D-3s51A:1.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sfz | APOPTOTIC PEPTIDASEACTIVATING FACTOR 1 (Mus musculus) |
PF00400(WD40)PF00931(NB-ARC)PF12894(ANAPC4_WD40) | 3 | ALA A 329VAL A 299TRP A 338 | None | 0.83A | 1av2C-3sfzA:undetectable1av2D-3sfzA:undetectable | 1av2C-3sfzA:1.801av2D-3sfzA:1.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uaj | ENVELOPE PROTEIN (Dengue virus) |
no annotation | 3 | ALA B 35VAL B 15TRP B 20 | None | 0.84A | 1av2C-3uajB:undetectable1av2D-3uajB:undetectable | 1av2C-3uajB:6.421av2D-3uajB:6.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v48 | PUTATIVEAMINOACRYLATEHYDROLASE RUTD (Escherichiacoli) |
PF00561(Abhydrolase_1) | 3 | ALA A 91VAL A 85TRP A 29 | None | 0.86A | 1av2C-3v48A:undetectable1av2D-3v48A:undetectable | 1av2C-3v48A:6.991av2D-3v48A:6.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4h | HYPOTHETICAL PROTEIN (Yersinia pestis) |
PF05638(T6SS_HCP) | 3 | ALA A 35VAL A 53TRP A 32 | None | 0.83A | 1av2C-3v4hA:undetectable1av2D-3v4hA:undetectable | 1av2C-3v4hA:10.001av2D-3v4hA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w04 | DWARF 88 ESTERASE (Oryza sativa) |
PF12697(Abhydrolase_6) | 3 | ALA A 150VAL A 144TRP A 85 | None | 0.87A | 1av2C-3w04A:undetectable1av2D-3w04A:undetectable | 1av2C-3w04A:8.331av2D-3w04A:8.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4asi | ACETYL-COACARBOXYLASE 1 (Homo sapiens) |
PF01039(Carboxyl_trans) | 3 | ALA A1739VAL A1716TRP A1699 | None | 0.85A | 1av2C-4asiA:undetectable1av2D-4asiA:undetectable | 1av2C-4asiA:1.861av2D-4asiA:1.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bj4 | AMPDH2 (Pseudomonasaeruginosa) |
PF01471(PG_binding_1)PF01510(Amidase_2) | 3 | ALA A 87VAL A 89TRP A 97 | NoneNoneFLC A1260 (-4.9A) | 0.79A | 1av2C-4bj4A:undetectable1av2D-4bj4A:undetectable | 1av2C-4bj4A:7.481av2D-4bj4A:7.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bvl | PHB DEPOLYMERASEPHAZ7 (Paucimonaslemoignei) |
PF01674(Lipase_2) | 3 | ALA A 295VAL A 244TRP A 287 | None | 0.88A | 1av2C-4bvlA:undetectable1av2D-4bvlA:undetectable | 1av2C-4bvlA:4.981av2D-4bvlA:4.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c90 | ALPHA-GLUCURONIDASEGH115 (Bacteroidesovatus) |
PF15979(Glyco_hydro_115) | 3 | ALA A 230VAL A 232TRP A 172 | None | 0.85A | 1av2C-4c90A:undetectable1av2D-4c90A:undetectable | 1av2C-4c90A:3.201av2D-4c90A:3.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cot | EXTRACELLULARENDO-ALPHA-(1->5)-L-ARABINANASE 2 (Bacillussubtilis) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 3 | ALA A 127VAL A 170TRP A 100 | NoneTRS A1471 (-3.9A)TRS A1471 (-3.5A) | 0.85A | 1av2C-4cotA:undetectable1av2D-4cotA:undetectable | 1av2C-4cotA:6.781av2D-4cotA:6.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f53 | SUSD HOMOLOG (Bacteroidesovatus) |
PF12741(SusD-like) | 3 | ALA A 202VAL A 48TRP A 45 | None | 0.88A | 1av2C-4f53A:undetectable1av2D-4f53A:undetectable | 1av2C-4f53A:2.621av2D-4f53A:2.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fx0 | PROBABLETRANSCRIPTIONALREPRESSOR PROTEIN (Mycobacteriumtuberculosis) |
PF12802(MarR_2) | 3 | ALA A 138VAL A 133TRP A 130 | None | 0.86A | 1av2C-4fx0A:undetectable1av2D-4fx0A:undetectable | 1av2C-4fx0A:7.971av2D-4fx0A:7.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jbe | GAMMA-GLUTAMYLPHOSPHATE REDUCTASE (Saccharomonosporaviridis) |
PF00171(Aldedh) | 3 | ALA A 287VAL A 282TRP A 279 | ALA A 287 ( 0.0A)VAL A 282 ( 0.6A)TRP A 279 ( 0.5A) | 0.86A | 1av2C-4jbeA:undetectable1av2D-4jbeA:undetectable | 1av2C-4jbeA:7.361av2D-4jbeA:7.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jx6 | PYRUVATE CARBOXYLASE (Rhizobium etli) |
PF00682(HMGL-like)PF02436(PYC_OADA) | 3 | ALA A 869VAL A 864TRP A 861 | None | 0.84A | 1av2C-4jx6A:undetectable1av2D-4jx6A:undetectable | 1av2C-4jx6A:5.061av2D-4jx6A:5.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jyp | HYDROLASE,ALPHA/BETA FOLDFAMILY PROTEIN (Arabidopsisthaliana) |
PF12697(Abhydrolase_6) | 3 | ALA A 98VAL A 92TRP A 33 | None | 0.82A | 1av2C-4jypA:undetectable1av2D-4jypA:undetectable | 1av2C-4jypA:9.801av2D-4jypA:9.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mkv | RIBULOSEBISPHOSPHATECARBOXYLASE LARGECHAIN (Pisum sativum) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 3 | ALA A 15VAL A 17TRP A 66 | None | 0.83A | 1av2C-4mkvA:undetectable1av2D-4mkvA:undetectable | 1av2C-4mkvA:3.791av2D-4mkvA:3.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4om9 | SERINE PROTEASE PET (Escherichiacoli) |
PF02395(Peptidase_S6) | 3 | ALA A 328VAL A 326TRP A 351 | None | 0.53A | 1av2C-4om9A:undetectable1av2D-4om9A:undetectable | 1av2C-4om9A:1.651av2D-4om9A:1.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oxc | E3 UBIQUITIN-PROTEINLIGASE XIAP (Homo sapiens) |
PF00653(BIR) | 3 | ALA A 44VAL A 42TRP A 73 | None | 0.86A | 1av2C-4oxcA:undetectable1av2D-4oxcA:undetectable | 1av2C-4oxcA:6.311av2D-4oxcA:6.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4piv | FATTY ACID SYNTHASE (Homo sapiens) |
PF08242(Methyltransf_12)PF08659(KR) | 3 | ALA A1272VAL A1245TRP A1297 | None | 0.87A | 1av2C-4pivA:undetectable1av2D-4pivA:undetectable | 1av2C-4pivA:3.181av2D-4pivA:3.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2c | CRISPR-ASSOCIATEDHELICASE CAS3 (Thermobaculumterrenum) |
PF00271(Helicase_C) | 3 | ALA A 230VAL A 235TRP A 238 | None | 0.85A | 1av2C-4q2cA:undetectable1av2D-4q2cA:undetectable | 1av2C-4q2cA:1.961av2D-4q2cA:1.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qjy | GH127BETA-L-ARABINOFURANOSIDASE (Geobacillusstearothermophilus) |
PF07944(Glyco_hydro_127) | 3 | ALA A 144VAL A 80TRP A 76 | None | 0.68A | 1av2C-4qjyA:undetectable1av2D-4qjyA:undetectable | 1av2C-4qjyA:3.341av2D-4qjyA:3.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtt | MULTIFUNCTIONALMETHYLTRANSFERASESUBUNIT TRM112 (Saccharomycescerevisiae) |
PF03966(Trm112p) | 3 | ALA A 64VAL A 59TRP A 56 | None | 0.80A | 1av2C-4qttA:undetectable1av2D-4qttA:undetectable | 1av2C-4qttA:5.831av2D-4qttA:5.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4usr | MONOOXYGENASE (Pseudomonasstutzeri) |
PF13738(Pyr_redox_3) | 3 | ALA A 181VAL A 179TRP A 47 | None | 0.86A | 1av2C-4usrA:undetectable1av2D-4usrA:undetectable | 1av2C-4usrA:4.391av2D-4usrA:4.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uuo | CYTOSOLIC MALATEDEHYDROGENASE (Trichomonasvaginalis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | ALA A 152VAL A 124TRP A 150 | None | 0.73A | 1av2C-4uuoA:undetectable1av2D-4uuoA:undetectable | 1av2C-4uuoA:6.801av2D-4uuoA:6.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xnv | P2Y PURINOCEPTOR 1,RUBREDOXIN, P2YPURINOCEPTOR 1 (Clostridiumpasteurianum;Homo sapiens) |
PF00001(7tm_1)PF00301(Rubredoxin) | 3 | ALA A 72VAL A 77TRP A 83 | None | 0.81A | 1av2C-4xnvA:undetectable1av2D-4xnvA:undetectable | 1av2C-4xnvA:4.611av2D-4xnvA:4.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwl | EXOGLUCANASE S (Clostridiumcellulovorans) |
PF02011(Glyco_hydro_48) | 3 | ALA A 598VAL A 593TRP A 590 | None | 0.70A | 1av2C-4xwlA:undetectable1av2D-4xwlA:undetectable | 1av2C-4xwlA:2.841av2D-4xwlA:2.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9s | EPOXIDE HYDROLASE (Solanumtuberosum) |
PF00561(Abhydrolase_1) | 3 | ALA A 111VAL A 102TRP A 40 | None | 0.89A | 1av2C-4y9sA:undetectable1av2D-4y9sA:undetectable | 1av2C-4y9sA:5.111av2D-4y9sA:5.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zfm | PUTATIVE6-PHOSPHO-BETA-GALACTOBIOSIDASE (Geobacillusstearothermophilus) |
PF00232(Glyco_hydro_1) | 3 | ALA A 476VAL A 470TRP A 15 | None | 0.85A | 1av2C-4zfmA:undetectable1av2D-4zfmA:undetectable | 1av2C-4zfmA:2.931av2D-4zfmA:2.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7m | BETA-XYLOSIDASE (Trichodermareesei) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 3 | ALA A 382VAL A 377TRP A 374 | NAG A1501 (-4.1A)NoneNone | 0.70A | 1av2C-5a7mA:undetectable1av2D-5a7mA:undetectable | 1av2C-5a7mA:1.951av2D-5a7mA:1.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3g | PROTEIN SHORT-ROOT (Arabidopsisthaliana) |
PF03514(GRAS) | 3 | ALA B 393VAL B 522TRP B 234 | None | 0.58A | 1av2C-5b3gB:undetectable1av2D-5b3gB:undetectable | 1av2C-5b3gB:5.751av2D-5b3gB:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3h | PROTEIN SHORT-ROOT (Arabidopsisthaliana) |
PF03514(GRAS) | 3 | ALA B 393VAL B 522TRP B 234 | None | 0.62A | 1av2C-5b3hB:undetectable1av2D-5b3hB:undetectable | 1av2C-5b3hB:5.751av2D-5b3hB:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3u | L-SERINEAMMONIA-LYASE (Rhizomucormiehei) |
PF00291(PALP) | 3 | ALA A 133VAL A 100TRP A 126 | None | 0.88A | 1av2C-5c3uA:undetectable1av2D-5c3uA:undetectable | 1av2C-5c3uA:5.171av2D-5c3uA:5.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5djo | KINESIN-LIKE PROTEIN (Mus musculus) |
PF00498(FHA)PF16183(Kinesin_assoc) | 3 | ALA A 89VAL A 87TRP A 148 | None | 0.86A | 1av2C-5djoA:undetectable1av2D-5djoA:undetectable | 1av2C-5djoA:11.831av2D-5djoA:11.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dnw | SHKAI2IB (Strigahermonthica) |
PF12697(Abhydrolase_6) | 3 | ALA A 98VAL A 92TRP A 33 | None | 0.74A | 1av2C-5dnwA:undetectable1av2D-5dnwA:undetectable | 1av2C-5dnwA:5.211av2D-5dnwA:5.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ees | 4-HYDROXY-TETRAHYDRODIPICOLINATEREDUCTASE (Corynebacteriumglutamicum) |
PF01113(DapB_N)PF05173(DapB_C) | 3 | ALA A 84VAL A 89TRP A 92 | None | 0.88A | 1av2C-5eesA:undetectable1av2D-5eesA:undetectable | 1av2C-5eesA:4.101av2D-5eesA:4.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fda | DIHYDROFOLATEREDUCTASE (Yersinia pestis) |
PF00186(DHFR_1) | 3 | ALA A 77VAL A 62TRP A 75 | None | 0.87A | 1av2C-5fdaA:undetectable1av2D-5fdaA:undetectable | 1av2C-5fdaA:9.241av2D-5fdaA:9.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5n | LH3HEXON-INTERLACINGCAPSID PROTEIN (Snakeatadenovirus A) |
PF01696(Adeno_E1B_55K) | 3 | ALA A 53VAL A 75TRP A 57 | None | 0.79A | 1av2C-5g5nA:undetectable1av2D-5g5nA:undetectable | 1av2C-5g5nA:5.151av2D-5g5nA:5.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5z | ABC TRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF01547(SBP_bac_1) | 3 | ALA A 429VAL A 380TRP A 384 | NoneNoneDQR A 544 (-4.1A) | 0.85A | 1av2C-5g5zA:undetectable1av2D-5g5zA:undetectable | 1av2C-5g5zA:2.851av2D-5g5zA:2.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gz4 | SNAKE VENOMPHOSPHODIESTERASE(PDE) (Naja atra) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 3 | ALA A 277VAL A 282TRP A 285 | None | 0.83A | 1av2C-5gz4A:undetectable1av2D-5gz4A:undetectable | 1av2C-5gz4A:1.901av2D-5gz4A:1.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8w | ATP-DEPENDENT DNAHELICASE TA0057 (Thermoplasmaacidophilum) |
PF06733(DEAD_2)PF06777(HBB)PF13307(Helicase_C_2) | 3 | ALA A 558VAL A 553TRP A 549 | None | 0.87A | 1av2C-5h8wA:undetectable1av2D-5h8wA:undetectable | 1av2C-5h8wA:4.351av2D-5h8wA:4.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hb3 | NUCLEOPORIN NIC96 (Chaetomiumthermophilum) |
PF04097(Nic96) | 3 | ALA A 508VAL A 503TRP A 500 | None | 0.85A | 1av2C-5hb3A:undetectable1av2D-5hb3A:undetectable | 1av2C-5hb3A:2.681av2D-5hb3A:2.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hr4 | MMEI (Methylophilusmethylotrophus) |
no annotation | 3 | ALA C 422VAL C 424TRP C 427 | None | 0.82A | 1av2C-5hr4C:undetectable1av2D-5hr4C:undetectable | 1av2C-5hr4C:2.721av2D-5hr4C:2.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzg | STRIGOLACTONEESTERASE D14 (Arabidopsisthaliana) |
PF12697(Abhydrolase_6) | 3 | ALA A 100VAL A 94TRP A 35 | None | 0.81A | 1av2C-5hzgA:undetectable1av2D-5hzgA:undetectable | 1av2C-5hzgA:4.351av2D-5hzgA:4.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j44 | SERINE PROTEASE SEPAAUTOTRANSPORTER (Shigellaflexneri) |
PF02395(Peptidase_S6) | 3 | ALA A 338VAL A 336TRP A 359 | None | 0.89A | 1av2C-5j44A:undetectable1av2D-5j44A:undetectable | 1av2C-5j44A:1.601av2D-5j44A:1.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9s | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (MANNOPINE) (Agrobacteriumfabrum) |
PF13416(SBP_bac_8) | 3 | ALA A 84VAL A 82TRP A 93 | None | 0.83A | 1av2C-5l9sA:undetectable1av2D-5l9sA:undetectable | 1av2C-5l9sA:4.091av2D-5l9sA:4.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lew | DNA POLYMERASE IIISUBUNIT ALPHA (Mycobacteriumtuberculosis) |
no annotation | 3 | ALA A 789VAL A 794TRP A 797 | None | 0.83A | 1av2C-5lewA:undetectable1av2D-5lewA:undetectable | 1av2C-5lewA:1.831av2D-5lewA:1.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m3x | ANGIOTENSINOGEN (Homo sapiens) |
no annotation | 3 | ALA A 71VAL A 73TRP A 133 | None | 0.79A | 1av2C-5m3xA:undetectable1av2D-5m3xA:undetectable | 1av2C-5m3xA:undetectable1av2D-5m3xA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msc | CARBOXYLIC ACIDREDUCTASE (Nocardiaiowensis) |
PF00501(AMP-binding) | 3 | ALA A 102VAL A 97TRP A 94 | None | 0.79A | 1av2C-5mscA:undetectable1av2D-5mscA:undetectable | 1av2C-5mscA:1.501av2D-5mscA:1.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nv3 | RIBULOSEBISPHOSPHATECARBOXYLASE LARGECHAIN (Rhodobactersphaeroides) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 3 | ALA A 16VAL A 18TRP A 68 | None | 0.79A | 1av2C-5nv3A:undetectable1av2D-5nv3A:undetectable | 1av2C-5nv3A:3.901av2D-5nv3A:3.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nxy | OSMOTICALLYACTIVATEDL-CARNITINE/CHOLINEABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN OPUCC (Bacillussubtilis) |
no annotation | 3 | ALA A 188VAL A 140TRP A 144 | None | 0.81A | 1av2C-5nxyA:undetectable1av2D-5nxyA:undetectable | 1av2C-5nxyA:undetectable1av2D-5nxyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nyj | ANBU (Hyphomicrobiumsp. MC1) |
PF00227(Proteasome) | 3 | ALA A 93VAL A 59TRP A 36 | None | 0.89A | 1av2C-5nyjA:undetectable1av2D-5nyjA:undetectable | 1av2C-5nyjA:4.441av2D-5nyjA:4.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uv2 | (+)-LIMONENESYNTHASE (Citrus sinensis) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 3 | ALA A 370VAL A 362TRP A 365 | None | 0.89A | 1av2C-5uv2A:undetectable1av2D-5uv2A:undetectable | 1av2C-5uv2A:4.761av2D-5uv2A:4.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xea | ENVELOPEGLYCOPROTEIN (Thogotothogotovirus) |
PF03273(Baculo_gp64) | 3 | ALA A 297VAL A 295TRP A 292 | None | 0.85A | 1av2C-5xeaA:undetectable1av2D-5xeaA:undetectable | 1av2C-5xeaA:4.351av2D-5xeaA:4.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxu | RIBOSOMAL PROTEINES19 (Toxoplasmagondii) |
PF01090(Ribosomal_S19e) | 3 | ALA T 53VAL T 50TRP T 65 | None A 21501 ( 4.5A)None | 0.84A | 1av2C-5xxuT:undetectable1av2D-5xxuT:undetectable | 1av2C-5xxuT:12.731av2D-5xxuT:12.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ap6 | PROBABLESTRIGOLACTONEESTERASE DAD2 (Petunia xhybrida) |
no annotation | 3 | ALA A 99VAL A 93TRP A 34 | None | 0.87A | 1av2C-6ap6A:undetectable1av2D-6ap6A:undetectable | 1av2C-6ap6A:undetectable1av2D-6ap6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ax6 | PROCOLLAGEN LYSYLHYDROXYLASE ANDGLYCOSYLTRANSFERASE (Acanthamoebapolyphagamimivirus) |
no annotation | 3 | ALA A 791VAL A 785TRP A 782 | IOD A 902 ( 3.9A)NoneNone | 0.88A | 1av2C-6ax6A:undetectable1av2D-6ax6A:undetectable | 1av2C-6ax6A:undetectable1av2D-6ax6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c0w | HISTONE H3-LIKECENTROMERIC PROTEINAHISTONE H4 (Homo sapiens;Homo sapiens) |
no annotationno annotation | 3 | ALA B 83VAL B 81TRP A 86 | ALA B 83 ( 0.0A)VAL B 81 ( 0.6A)TRP A 86 ( 0.5A) | 0.79A | 1av2C-6c0wB:undetectable1av2D-6c0wB:undetectable | 1av2C-6c0wB:undetectable1av2D-6c0wB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cia | ALDO/KETO REDUCTASE (Klebsiellapneumoniae) |
no annotation | 3 | ALA A 86VAL A 124TRP A 139 | None | 0.79A | 1av2C-6ciaA:undetectable1av2D-6ciaA:undetectable | 1av2C-6ciaA:undetectable1av2D-6ciaA:undetectable |