SIMILAR PATTERNS OF AMINO ACIDS FOR 1AV2_B_DVAB8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 VAL A  22
VAL A  59
TRP A  57
 None
 0.88A 1av2A-1bf2A:
undetectable
1av2B-1bf2A:
undetectable		 1av2A-1bf2A:
2.38
1av2B-1bf2A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		3 VAL A 191
VAL A  85
TRP A 103
 None
 1.00A 1av2A-1ci9A:
undetectable
1av2B-1ci9A:
undetectable		 1av2A-1ci9A:
8.97
1av2B-1ci9A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		3 VAL A 164
VAL A 205
TRP A 168
 None
 0.87A 1av2A-1g38A:
undetectable
1av2B-1g38A:
undetectable		 1av2A-1g38A:
5.10
1av2B-1g38A:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 VAL A 269
VAL A 271
TRP A 290
 None
 0.95A 1av2A-1h7zA:
undetectable
1av2B-1h7zA:
undetectable		 1av2A-1h7zA:
7.63
1av2B-1h7zA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		3 VAL A 116
VAL A 139
TRP A 158
 None
 0.95A 1av2A-1hixA:
undetectable
1av2B-1hixA:
undetectable		 1av2A-1hixA:
8.86
1av2B-1hixA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 VAL A 959
VAL A 935
TRP A 933
 None
 0.85A 1av2A-1i8qA:
undetectable
1av2B-1i8qA:
undetectable		 1av2A-1i8qA:
1.42
1av2B-1i8qA:
1.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id2 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		3 VAL A  24
VAL A  22
TRP A  46
 None
 0.72A 1av2A-1id2A:
undetectable
1av2B-1id2A:
undetectable		 1av2A-1id2A:
8.89
1av2B-1id2A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00977
(His_biosynth) 		3 VAL F 141
VAL F 143
TRP F 157
 None
 1.00A 1av2A-1ka9F:
undetectable
1av2B-1ka9F:
undetectable		 1av2A-1ka9F:
5.49
1av2B-1ka9F:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		3 VAL A 229
VAL A 262
TRP A 264
 None
 0.95A 1av2A-1m2wA:
undetectable
1av2B-1m2wA:
undetectable		 1av2A-1m2wA:
2.87
1av2B-1m2wA:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		3 VAL A  32
VAL A  34
TRP A  80
 None
 0.66A 1av2A-1mbmA:
undetectable
1av2B-1mbmA:
undetectable		 1av2A-1mbmA:
12.94
1av2B-1mbmA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 VAL A 763
VAL A 797
TRP A 689
 None
 0.95A 1av2A-1ogyA:
undetectable
1av2B-1ogyA:
undetectable		 1av2A-1ogyA:
5.19
1av2B-1ogyA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uen KIAA0343 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		3 VAL A  21
VAL A  23
TRP A  35
 None
 0.88A 1av2A-1uenA:
undetectable
1av2B-1uenA:
undetectable		 1av2A-1uenA:
14.29
1av2B-1uenA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg4 HYPOTHETICAL PROTEIN
(RIKEN CDNA
6030486K23)

(Mus musculus) 		PF00076
(RRM_1) 		3 VAL A  47
VAL A  55
TRP A  29
 None
 0.76A 1av2A-1wg4A:
undetectable
1av2B-1wg4A:
undetectable		 1av2A-1wg4A:
9.88
1av2B-1wg4A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4c SPLICING FACTOR,
ARGININE/SERINE-RICH
1

(Mus musculus) 		PF00076
(RRM_1) 		3 VAL A  47
VAL A  55
TRP A  29
 None
 0.64A 1av2A-1x4cA:
undetectable
1av2B-1x4cA:
undetectable		 1av2A-1x4cA:
20.59
1av2B-1x4cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zub REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 VAL A 699
VAL A 614
TRP A 673
 None
 0.98A 1av2A-1zubA:
undetectable
1av2B-1zubA:
undetectable		 1av2A-1zubA:
8.41
1av2B-1zubA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME

(Homo sapiens) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 VAL A 293
VAL A 299
TRP A 297
 None
 0.86A 1av2A-1zxnA:
undetectable
1av2B-1zxnA:
undetectable		 1av2A-1zxnA:
3.74
1av2B-1zxnA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		3 VAL A 169
VAL A 165
TRP A 172
 None
 0.97A 1av2A-2cdaA:
undetectable
1av2B-2cdaA:
undetectable		 1av2A-2cdaA:
5.26
1av2B-2cdaA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csp RIM BINDING PROTEIN
2

(Homo sapiens) 		no annotation 3 VAL A  24
VAL A  26
TRP A  39
 None
 0.93A 1av2A-2cspA:
undetectable
1av2B-2cspA:
undetectable		 1av2A-2cspA:
8.04
1av2B-2cspA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbj PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE MER PRECURSOR

(Homo sapiens) 		no annotation 3 VAL A  25
VAL A  27
TRP A  40
 None
 0.92A 1av2A-2dbjA:
undetectable
1av2B-2dbjA:
undetectable		 1av2A-2dbjA:
13.89
1av2B-2dbjA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo1 CDNA FLJ14124 FIS,
CLONE MAMMA1002498

(Homo sapiens) 		PF07679
(I-set) 		3 VAL A  59
VAL A  69
TRP A  44
 None
 1.00A 1av2A-2eo1A:
undetectable
1av2B-2eo1A:
undetectable		 1av2A-2eo1A:
11.36
1av2B-2eo1A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 VAL A  28
VAL A  64
TRP A   4
 None
 0.89A 1av2A-2glxA:
undetectable
1av2B-2glxA:
undetectable		 1av2A-2glxA:
4.42
1av2B-2glxA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA

(Homo sapiens) 		PF00046
(Homeobox)
PF04814
(HNF-1_N) 		3 VAL A 142
VAL A 140
TRP A 171
 None
 0.96A 1av2A-2h8rA:
undetectable
1av2B-2h8rA:
undetectable		 1av2A-2h8rA:
5.69
1av2B-2h8rA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if6 HYPOTHETICAL PROTEIN
YIIX

(Escherichia
coli) 		PF05708
(Peptidase_C92) 		3 VAL A 193
VAL A  87
TRP A  19
 None
 0.84A 1av2A-2if6A:
undetectable
1av2B-2if6A:
undetectable		 1av2A-2if6A:
8.27
1av2B-2if6A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jw4 CYTOPLASMIC PROTEIN
NCK1

(Homo sapiens) 		PF00018
(SH3_1) 		3 VAL A   9
VAL A  44
TRP A  33
 None
 0.68A 1av2A-2jw4A:
undetectable
1av2B-2jw4A:
undetectable		 1av2A-2jw4A:
21.43
1av2B-2jw4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2miz M04 IMMUNOEVASIN

(Murid
betaherpesvirus
1) 		PF12216
(m04gp34like) 		3 VAL A  71
VAL A  64
TRP A  62
 None
 0.75A 1av2A-2mizA:
undetectable
1av2B-2mizA:
undetectable		 1av2A-2mizA:
6.94
1av2B-2mizA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mkk CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 1

(Homo sapiens) 		PF16367
(RRM_7) 		3 VAL A 282
VAL A 264
TRP A 266
 None
 0.91A 1av2A-2mkkA:
undetectable
1av2B-2mkkA:
undetectable		 1av2A-2mkkA:
11.69
1av2B-2mkkA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE

(Macaca
fascicularis) 		PF01408
(GFO_IDH_MocA) 		3 VAL X1031
VAL X1067
TRP X1005
 None
 0.78A 1av2A-2o4uX:
undetectable
1av2B-2o4uX:
undetectable		 1av2A-2o4uX:
3.08
1av2B-2o4uX:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogj DIHYDROOROTASE

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		3 VAL A 325
VAL A 321
TRP A  73
 None
 0.98A 1av2A-2ogjA:
undetectable
1av2B-2ogjA:
undetectable		 1av2A-2ogjA:
3.38
1av2B-2ogjA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oik HISTIDINE TRIAD
(HIT) PROTEIN

(Methylobacillus
flagellatus) 		PF01230
(HIT) 		3 VAL A  44
VAL A 100
TRP A  98
 None
 0.90A 1av2A-2oikA:
undetectable
1av2B-2oikA:
undetectable		 1av2A-2oikA:
10.00
1av2B-2oikA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 VAL A 735
VAL A 725
TRP A 422
 None
 0.83A 1av2A-2pi5A:
undetectable
1av2B-2pi5A:
undetectable		 1av2A-2pi5A:
2.26
1av2B-2pi5A:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhk NON-STRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 VAL A 194
VAL A 192
TRP A 203
 None
None
NO3  A   3 (-4.3A)
 0.84A 1av2A-2rhkA:
undetectable
1av2B-2rhkA:
undetectable		 1av2A-2rhkA:
10.19
1av2B-2rhkA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		3 VAL A 119
VAL A 117
TRP A 120
 None
 0.57A 1av2A-2x66A:
undetectable
1av2B-2x66A:
undetectable		 1av2A-2x66A:
5.63
1av2B-2x66A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE

(Synechococcus
sp. WH 8020) 		PF05996
(Fe_bilin_red) 		3 VAL A  54
VAL A  83
TRP A  52
 None
 0.62A 1av2A-2x9oA:
undetectable
1av2B-2x9oA:
undetectable		 1av2A-2x9oA:
8.33
1av2B-2x9oA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		3 VAL A 307
VAL A  48
TRP A  46
 None
 0.87A 1av2A-2x9pA:
undetectable
1av2B-2x9pA:
undetectable		 1av2A-2x9pA:
3.88
1av2B-2x9pA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 415
VAL A 463
TRP A 411
 None
 0.91A 1av2A-2xk9A:
undetectable
1av2B-2xk9A:
undetectable		 1av2A-2xk9A:
4.68
1av2B-2xk9A:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuz MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		3 VAL A  54
VAL A  64
TRP A  39
 None
 0.98A 1av2A-2yuzA:
undetectable
1av2B-2yuzA:
undetectable		 1av2A-2yuzA:
8.54
1av2B-2yuzA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		3 VAL A  75
VAL A  42
TRP A  66
 None
 0.63A 1av2A-2z8eA:
undetectable
1av2B-2z8eA:
undetectable		 1av2A-2z8eA:
2.70
1av2B-2z8eA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		3 VAL A 229
VAL A   3
TRP A 178
 None
 0.99A 1av2A-3aquA:
undetectable
1av2B-3aquA:
undetectable		 1av2A-3aquA:
4.41
1av2B-3aquA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beg SPLICING FACTOR,
ARGININE/SERINE-RICH
1

(Homo sapiens) 		PF00076
(RRM_1) 		3 VAL B 152
VAL B 160
TRP B 134
 None
 0.86A 1av2A-3begB:
undetectable
1av2B-3begB:
undetectable		 1av2A-3begB:
22.86
1av2B-3begB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 207
VAL A 253
TRP A 203
 None
 0.88A 1av2A-3c0iA:
undetectable
1av2B-3c0iA:
undetectable		 1av2A-3c0iA:
4.76
1av2B-3c0iA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		3 VAL A  24
VAL A  22
TRP A  46
 None
 0.78A 1av2A-3c75A:
undetectable
1av2B-3c75A:
undetectable		 1av2A-3c75A:
8.89
1av2B-3c75A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnc FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 VAL A 303
VAL A 305
TRP A 324
 None
 0.99A 1av2A-3cncA:
undetectable
1av2B-3cncA:
undetectable		 1av2A-3cncA:
6.11
1av2B-3cncA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A1191
VAL A1228
TRP A1187
 None
 0.97A 1av2A-3dlsA:
undetectable
1av2B-3dlsA:
undetectable		 1av2A-3dlsA:
4.83
1av2B-3dlsA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 3 VAL A  64
VAL A  73
TRP A  71
 None
 0.74A 1av2A-3dsmA:
undetectable
1av2B-3dsmA:
undetectable		 1av2A-3dsmA:
6.62
1av2B-3dsmA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2

(Schizosaccharomyces
pombe) 		PF04045
(P34-Arc) 		3 VAL D 179
VAL D 244
TRP D 170
 None
 0.72A 1av2A-3dwlD:
undetectable
1av2B-3dwlD:
undetectable		 1av2A-3dwlD:
5.58
1av2B-3dwlD:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		3 VAL A 210
VAL A 257
TRP A 206
 None
 0.79A 1av2A-3dxnA:
undetectable
1av2B-3dxnA:
undetectable		 1av2A-3dxnA:
5.49
1av2B-3dxnA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec9 UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Burkholderia
thailandensis) 		PF12680
(SnoaL_2) 		3 VAL A  89
VAL A 116
TRP A 114
 None
 0.65A 1av2A-3ec9A:
undetectable
1av2B-3ec9A:
undetectable		 1av2A-3ec9A:
8.55
1av2B-3ec9A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee9 NON-STRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 VAL A 194
VAL A 192
TRP A 203
 None
 0.90A 1av2A-3ee9A:
undetectable
1av2B-3ee9A:
undetectable		 1av2A-3ee9A:
9.57
1av2B-3ee9A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		3 VAL A  37
VAL A  41
TRP A  38
 None
 0.99A 1av2A-3fz0A:
undetectable
1av2B-3fz0A:
undetectable		 1av2A-3fz0A:
7.69
1av2B-3fz0A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		3 VAL A 291
VAL A 284
TRP A 304
 None
None
EDO  A   7 (-3.9A)
 0.83A 1av2A-3hbcA:
undetectable
1av2B-3hbcA:
undetectable		 1av2A-3hbcA:
4.37
1av2B-3hbcA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 VAL A 263
VAL A 310
TRP A 259
 None
 0.79A 1av2A-3hztA:
undetectable
1av2B-3hztA:
undetectable		 1av2A-3hztA:
3.29
1av2B-3hztA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1a SPECTINOMYCIN
PHOSPHOTRANSFERASE

(Legionella
pneumophila) 		PF01636
(APH) 		3 VAL A 253
VAL A 250
TRP A 254
 None
 0.94A 1av2A-3i1aA:
undetectable
1av2B-3i1aA:
undetectable		 1av2A-3i1aA:
3.46
1av2B-3i1aA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		3 VAL A 415
VAL A 463
TRP A 411
 None
 0.98A 1av2A-3i6uA:
undetectable
1av2B-3i6uA:
undetectable		 1av2A-3i6uA:
3.30
1av2B-3i6uA:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		3 VAL X 320
VAL X 350
TRP X 323
 None
 0.87A 1av2A-3j8gX:
undetectable
1av2B-3j8gX:
undetectable		 1av2A-3j8gX:
4.10
1av2B-3j8gX:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3

(Saccharomyces
cerevisiae) 		PF06544
(DUF1115)
PF08572
(PRP3) 		3 VAL K 341
VAL K 383
TRP K 428
 None
 0.87A 1av2A-3jcmK:
undetectable
1av2B-3jcmK:
undetectable		 1av2A-3jcmK:
2.73
1av2B-3jcmK:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		3 VAL A 312
VAL A 235
TRP A 180
 None
 0.91A 1av2A-3kl9A:
undetectable
1av2B-3kl9A:
undetectable		 1av2A-3kl9A:
3.49
1av2B-3kl9A:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwg NON-STRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 VAL A 194
VAL A 192
TRP A 203
 None
 0.91A 1av2A-3kwgA:
undetectable
1av2B-3kwgA:
undetectable		 1av2A-3kwgA:
6.82
1av2B-3kwgA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		3 VAL A  19
VAL A  17
TRP A 311
 None
 0.92A 1av2A-3l12A:
undetectable
1av2B-3l12A:
undetectable		 1av2A-3l12A:
5.05
1av2B-3l12A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lic SENSOR PROTEIN

(Shewanella
oneidensis) 		PF02743
(dCache_1) 		3 VAL A 283
VAL A 290
TRP A 288
 None
 0.96A 1av2A-3licA:
undetectable
1av2B-3licA:
undetectable		 1av2A-3licA:
6.67
1av2B-3licA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		3 VAL A 521
VAL A 490
TRP A  23
 None
 0.99A 1av2A-3n2oA:
undetectable
1av2B-3n2oA:
undetectable		 1av2A-3n2oA:
3.11
1av2B-3n2oA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9t NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 VAL A 194
VAL A 192
TRP A 203
 None
 0.91A 1av2A-3o9tA:
undetectable
1av2B-3o9tA:
undetectable		 1av2A-3o9tA:
8.26
1av2B-3o9tA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4l NEOGENIN

(Homo sapiens) 		PF00041
(fn3) 		3 VAL A 961
VAL A 963
TRP A 977
 None
 0.97A 1av2A-3p4lA:
undetectable
1av2B-3p4lA:
undetectable		 1av2A-3p4lA:
6.51
1av2B-3p4lA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		3 VAL A  93
VAL A 103
TRP A 101
 None
 0.83A 1av2A-3q6tA:
undetectable
1av2B-3q6tA:
undetectable		 1av2A-3q6tA:
3.40
1av2B-3q6tA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		3 VAL A 214
VAL A 192
TRP A 190
 None
 0.82A 1av2A-3qs1A:
undetectable
1av2B-3qs1A:
undetectable		 1av2A-3qs1A:
12.82
1av2B-3qs1A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		3 VAL A  43
VAL A  92
TRP A  19
 None
 0.97A 1av2A-3rucA:
undetectable
1av2B-3rucA:
undetectable		 1av2A-3rucA:
3.45
1av2B-3rucA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 3 VAL A 144
VAL A  87
TRP A  85
 None
 0.96A 1av2A-3wevA:
undetectable
1av2B-3wevA:
undetectable		 1av2A-3wevA:
2.08
1av2B-3wevA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		3 VAL A 314
VAL A  41
TRP A  50
 None
 0.97A 1av2A-3wvsA:
undetectable
1av2B-3wvsA:
undetectable		 1av2A-3wvsA:
6.22
1av2B-3wvsA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqb NEOGENIN

(Mus musculus) 		PF00041
(fn3) 		3 VAL A 992
VAL A 994
TRP A1008
 None
 0.88A 1av2A-4bqbA:
undetectable
1av2B-4bqbA:
undetectable		 1av2A-4bqbA:
6.51
1av2B-4bqbA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		3 VAL A 146
VAL A  37
TRP A  35
 None
 0.67A 1av2A-4d3yA:
undetectable
1av2B-4d3yA:
undetectable		 1av2A-4d3yA:
2.98
1av2B-4d3yA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgu LEGUMAIN

(Homo sapiens) 		PF01650
(Peptidase_C13) 		3 VAL A 141
VAL A  32
TRP A  30
 None
 0.55A 1av2A-4fguA:
undetectable
1av2B-4fguA:
undetectable		 1av2A-4fguA:
2.88
1av2B-4fguA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3t OXIDOREDUCTASE DPRE1

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		3 VAL A 346
VAL A 393
TRP A 391
 None
 1.00A 1av2A-4g3tA:
undetectable
1av2B-4g3tA:
undetectable		 1av2A-4g3tA:
4.85
1av2B-4g3tA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqo ORNITHINE
CARBAMOYLTRANSFERASE

(Vibrio
vulnificus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 VAL A 327
VAL A 329
TRP A 127
 None
 0.98A 1av2A-4jqoA:
undetectable
1av2B-4jqoA:
undetectable		 1av2A-4jqoA:
2.87
1av2B-4jqoA:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 VAL A  28
VAL A  64
TRP A   4
 None
 0.87A 1av2A-4koaA:
undetectable
1av2B-4koaA:
undetectable		 1av2A-4koaA:
5.16
1av2B-4koaA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4liy FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 VAL A 269
VAL A 271
TRP A 290
 None
 0.96A 1av2A-4liyA:
undetectable
1av2B-4liyA:
undetectable		 1av2A-4liyA:
5.09
1av2B-4liyA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qma CYSTEINE DIOXYGENASE
TYPE I

(Cupriavidus
pinatubonensis) 		PF05995
(CDO_I) 		3 VAL A  98
VAL A 139
TRP A  99
 None
None
EDO  A 308 (-3.9A)
 0.67A 1av2A-4qmaA:
undetectable
1av2B-4qmaA:
undetectable		 1av2A-4qmaA:
9.20
1av2B-4qmaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		3 VAL B 205
VAL B 207
TRP B 218
 None
 0.95A 1av2A-4rs1B:
undetectable
1av2B-4rs1B:
undetectable		 1av2A-4rs1B:
2.56
1av2B-4rs1B:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		3 VAL A  79
VAL A  75
TRP A  80
 None
 0.92A 1av2A-4s0vA:
undetectable
1av2B-4s0vA:
undetectable		 1av2A-4s0vA:
6.95
1av2B-4s0vA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 VAL A 203
VAL A 171
TRP A 169
 None
 1.00A 1av2A-4tr6A:
undetectable
1av2B-4tr6A:
undetectable		 1av2A-4tr6A:
4.42
1av2B-4tr6A:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		3 VAL A1427
VAL A1367
TRP A1415
 None
 1.00A 1av2A-4w4tA:
undetectable
1av2B-4w4tA:
undetectable		 1av2A-4w4tA:
3.21
1av2B-4w4tA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		3 VAL A   5
VAL A 130
TRP A 147
 None
 1.00A 1av2A-4x4jA:
undetectable
1av2B-4x4jA:
undetectable		 1av2A-4x4jA:
3.07
1av2B-4x4jA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhy YFIR

(Pseudomonas
aeruginosa) 		PF13689
(DUF4154) 		3 VAL A 174
VAL A 176
TRP A  61
 None
 0.94A 1av2A-4zhyA:
undetectable
1av2B-4zhyA:
undetectable		 1av2A-4zhyA:
9.73
1av2B-4zhyA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4f GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Thermomonospora
curvata) 		PF00903
(Glyoxalase) 		3 VAL A 108
VAL A 118
TRP A 116
 None
 0.93A 1av2A-5d4fA:
undetectable
1av2B-5d4fA:
undetectable		 1av2A-5d4fA:
8.11
1av2B-5d4fA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en2 GD01 HEAVY CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Mus musculus;
Argentinian
mammarenavirus) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		3 VAL A  97
VAL C 117
TRP A  33
 None
 0.92A 1av2A-5en2A:
undetectable
1av2B-5en2A:
undetectable		 1av2A-5en2A:
6.03
1av2B-5en2A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idk GENOME
POLYPROTEIN,SERINE
PROTEASE SUBUNIT
NS2B, SERINE
PROTEASE NS3

(West Nile virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		3 VAL A1003
VAL A1072
TRP A1005
 None
 0.61A 1av2A-5idkA:
undetectable
1av2B-5idkA:
undetectable		 1av2A-5idkA:
10.89
1av2B-5idkA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 766
VAL A 812
TRP A 762
 None
 0.80A 1av2A-5lohA:
undetectable
1av2B-5lohA:
undetectable		 1av2A-5lohA:
5.49
1av2B-5lohA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lub LEGUMAIN

(Homo sapiens) 		no annotation 3 VAL B 141
VAL B  32
TRP B  30
 None
 0.59A 1av2A-5lubB:
undetectable
1av2B-5lubB:
undetectable		 1av2A-5lubB:
4.33
1av2B-5lubB:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Escherichia
coli) 		PF01977
(UbiD) 		3 VAL A 385
VAL A 381
TRP A 386
 None
 1.00A 1av2A-5m1bA:
undetectable
1av2B-5m1bA:
undetectable		 1av2A-5m1bA:
3.01
1av2B-5m1bA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4k NUCLEOPROTEIN

(Human
coronavirus
NL63) 		PF00937
(Corona_nucleoca) 		3 VAL A  99
VAL A  58
TRP A  56
 None
 0.97A 1av2A-5n4kA:
undetectable
1av2B-5n4kA:
undetectable		 1av2A-5n4kA:
6.12
1av2B-5n4kA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 3 VAL A 239
VAL A 176
TRP A 237
 None
 0.66A 1av2A-5no8A:
undetectable
1av2B-5no8A:
undetectable		 1av2A-5no8A:
1.64
1av2B-5no8A:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Caenorhabditis
elegans) 		no annotation 3 VAL A 193
VAL A 226
TRP A 203
 ISN  A 302 (-3.4A)
None
None
 0.99A 1av2A-5ojiA:
undetectable
1av2B-5ojiA:
undetectable		 1av2A-5ojiA:
5.79
1av2B-5ojiA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owx GENOME POLYPROTEIN

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 VAL 2 160
VAL 2 107
TRP 2 105
 None
 0.90A 1av2A-5owx2:
undetectable
1av2B-5owx2:
undetectable		 1av2A-5owx2:
8.05
1av2B-5owx2:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		3 VAL 8 130
VAL 8 134
TRP 8 239
 None
 0.93A 1av2A-5udb8:
undetectable
1av2B-5udb8:
undetectable		 1av2A-5udb8:
3.26
1av2B-5udb8:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wox UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 3 VAL A  79
VAL A  94
TRP A  92
 None
 0.46A 1av2A-5woxA:
undetectable
1av2B-5woxA:
undetectable		 1av2A-5woxA:
undetectable
1av2B-5woxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 3 VAL A  35
VAL A  90
TRP A  88
 None
 0.77A 1av2A-5x3jA:
undetectable
1av2B-5x3jA:
undetectable		 1av2A-5x3jA:
undetectable
1av2B-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 3 VAL A 352
VAL A 340
TRP A 354
 None
 0.88A 1av2A-5x89A:
undetectable
1av2B-5x89A:
undetectable		 1av2A-5x89A:
undetectable
1av2B-5x89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yht HISTIDINOL-PHOSPHATA
SE

(Mycobacterium
tuberculosis) 		no annotation 3 VAL A  64
VAL A  82
TRP A  80
 None
 0.86A 1av2A-5yhtA:
undetectable
1av2B-5yhtA:
undetectable		 1av2A-5yhtA:
undetectable
1av2B-5yhtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdm -

(-) 		no annotation 3 VAL A 132
VAL A 108
TRP A 106
 None
 0.69A 1av2A-5zdmA:
undetectable
1av2B-5zdmA:
undetectable		 1av2A-5zdmA:
undetectable
1av2B-5zdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 3 VAL B 245
VAL B 178
TRP B 176
 None
 0.94A 1av2A-6bywB:
undetectable
1av2B-6bywB:
undetectable		 1av2A-6bywB:
undetectable
1av2B-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dhi -

(-) 		no annotation 3 VAL A 158
VAL A  49
TRP A  47
 None
 0.73A 1av2A-6dhiA:
undetectable
1av2B-6dhiA:
undetectable		 1av2A-6dhiA:
undetectable
1av2B-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 VAL A1218
VAL A1285
TRP A1284
 None
 0.88A 1av2A-6emkA:
undetectable
1av2B-6emkA:
undetectable		 1av2A-6emkA:
undetectable
1av2B-6emkA:
undetectable