SIMILAR PATTERNS OF AMINO ACIDS FOR 1AQ7_B_AG2B4_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
None
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.80A 1aq7A-1a0jA:
41.1		 1aq7A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		7 HIS A  57
ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.48A 1aq7A-1a0jA:
41.1		 1aq7A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 0GJ  A 245 (-2.7A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-3.5A)
0GJ  A 245 (-1.4A)
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
 0.70A 1aq7A-1a5iA:
31.5		 1aq7A-1a5iA:
37.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afq BOVINE
GAMMA-CHYMOTRYPSIN

(Bos taurus) 		PF00089
(Trypsin) 		5 SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
0FG  C 301 ( 3.0A)
None
0FG  C 301 (-3.4A)
0FG  C 301 ( 4.4A)
 0.64A 1aq7A-1afqC:
9.3		 1aq7A-1afqC:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		4 HIS A  57
SER A 195
VAL A 213
GLY A 216
 0H8  A   1 (-3.3A)
0H8  A   1 (-1.5A)
None
0H8  A   1 (-4.2A)
 0.60A 1aq7A-1au8A:
35.3		 1aq7A-1au8A:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0GJ  A   1 ( 2.7A)
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
 0.64A 1aq7A-1bqyA:
34.7		 1aq7A-1bqyA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		5 HIS P  57
SER P 190
SER P 195
VAL P 213
GLY P 216
 1NB  P   1 (-3.9A)
1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
 0.55A 1aq7A-1bruP:
36.3		 1aq7A-1bruP:
40.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cte CATHEPSIN B

(Rattus
norvegicus) 		PF00112
(Peptidase_C1) 		5 ASP A 143
SER A  39
VAL A  52
GLY A  91
GLY A  99
 None
 1.28A 1aq7A-1cteA:
undetectable		 1aq7A-1cteA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cte CATHEPSIN B

(Rattus
norvegicus) 		PF00112
(Peptidase_C1) 		5 SER A  90
SER A  39
VAL A  52
GLY A  92
GLY A  99
 None
 1.12A 1aq7A-1cteA:
undetectable		 1aq7A-1cteA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		6 HIS B  57
SER B 190
SER B 195
VAL B 213
GLY B 216
GLY B 226
 None
 0.77A 1aq7A-1dlkB:
36.2		 1aq7A-1dlkB:
43.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		7 HIS B  57
ASP B 189
SER B 190
GLN B 192
SER B 195
GLY B 216
GLY B 226
 None
 0.55A 1aq7A-1ekbB:
36.6		 1aq7A-1ekbB:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		7 HIS A 460
ASP A 611
SER A 612
SER A 617
VAL A 638
GLY A 641
GLY A 648
 SO4  A2001 ( 3.9A)
None
None
SO4  A2001 ( 2.7A)
None
None
None
 0.54A 1aq7A-1elvA:
31.4		 1aq7A-1elvA:
30.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 ASP C 189
SER C 190
GLN C 192
SER C 195
GLY C 219
 None
 1.39A 1aq7A-1eptC:
12.7		 1aq7A-1eptC:
81.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		8 HIS A  57
ASP C 189
SER C 190
GLN C 192
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.47A 1aq7A-1eptA:
3.0		 1aq7A-1eptA:
90.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1euf DUODENASE

(Bos taurus) 		PF00089
(Trypsin) 		5 HIS A  57
SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.69A 1aq7A-1eufA:
35.6		 1aq7A-1eufA:
38.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fi8 NATURAL KILLER CELL
PROTEASE 1

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 HIS A  57
SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.51A 1aq7A-1fi8A:
35.9		 1aq7A-1fi8A:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-3.2A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.90A 1aq7A-1fiwA:
34.4		 1aq7A-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.6A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
 0.68A 1aq7A-1fizA:
33.8		 1aq7A-1fizA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fq3 GRANZYME B

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
SER A 190
SER A 195
VAL A 213
GLY A 216
 SO4  A 800 (-4.3A)
None
SO4  A 800 (-2.4A)
None
None
 0.85A 1aq7A-1fq3A:
34.9		 1aq7A-1fq3A:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-3.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.59A 1aq7A-1fxyA:
37.7		 1aq7A-1fxyA:
55.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 ASP A 145
SER A 200
VAL A 334
GLY A 329
GLY A 141
 None
 1.04A 1aq7A-1gk2A:
undetectable		 1aq7A-1gk2A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpz COMPLEMENT C1R
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 HIS A 485
SER A 637
VAL A 657
GLY A 668
 None
 0.34A 1aq7A-1gpzA:
26.6		 1aq7A-1gpzA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvl KALLIKREIN 6

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.47A 1aq7A-1gvlA:
27.7		 1aq7A-1gvlA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
BEN  A 250 (-2.9A)
BEN  A 250 (-2.9A)
BEN  A 250 (-3.8A)
BEN  A 250 (-3.6A)
None
BEN  A 250 (-3.9A)
BEN  A 250 (-3.3A)
 0.76A 1aq7A-1h4wA:
42.6		 1aq7A-1h4wA:
72.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		8 HIS E  57
ASP E 189
SER E 190
GLN E 192
SER E 195
VAL E 213
GLY E 216
GLY E 226
 None
 0.48A 1aq7A-1h9hE:
43.5		 1aq7A-1h9hE:
82.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		6 HIS H  57
ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 None
 0.66A 1aq7A-1id5H:
33.6		 1aq7A-1id5H:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		6 HIS T  57
ASP T 189
SER T 195
VAL T 213
GLY T 216
GLY T 226
 SO4  T 600 (-3.8A)
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
 0.46A 1aq7A-1j17T:
42.9		 1aq7A-1j17T:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		6 HIS H  57
ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 None
 0.63A 1aq7A-1kigH:
34.2		 1aq7A-1kigH:
40.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 SER A 208
SER A 150
GLY A 144
GLY A  12
 None
None
ATP  A 535 ( 3.2A)
None
 0.71A 1aq7A-1kvkA:
undetectable		 1aq7A-1kvkA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		7 HIS A  57
ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.46A 1aq7A-1mbqA:
40.6		 1aq7A-1mbqA:
65.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 HIS K  57
SER K 195
VAL K 213
GLY K 226
 None
 0.49A 1aq7A-1mkxK:
27.3		 1aq7A-1mkxK:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.72A 1aq7A-1npmA:
37.2		 1aq7A-1npmA:
45.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS H  57
ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 CR9  H 256 (-3.9A)
CR9  H 256 (-2.4A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
CR9  H 256 ( 3.8A)
CR9  H 256 (-3.0A)
 0.51A 1aq7A-1o5fH:
34.9		 1aq7A-1o5fH:
41.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ASP A1105
SER A1059
GLN A 969
GLY A1063
GLY A1106
 FMN  A2508 (-3.0A)
FMN  A2508 ( 3.9A)
AKG  A2510 ( 2.7A)
FMN  A2508 (-3.1A)
FMN  A2508 (-3.4A)
 1.49A 1aq7A-1ofeA:
undetectable		 1aq7A-1ofeA:
9.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.66A 1aq7A-1op2A:
33.8		 1aq7A-1op2A:
41.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.55A 1aq7A-1orfA:
34.3		 1aq7A-1orfA:
35.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		5 GLN A 343
SER A 341
VAL A 378
GLY A 367
GLY A 374
 CA  A 605 (-2.9A)
None
None
None
None
 1.49A 1aq7A-1p49A:
undetectable		 1aq7A-1p49A:
15.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		6 HIS C  57
ASP C 189
SER C 190
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.59A 1aq7A-1pfxC:
34.5		 1aq7A-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		8 HIS A  56
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 210
GLY A 213
GLY A 223
 ARG  A 703 (-4.3A)
ARG  A 703 (-2.0A)
ARG  A 703 (-2.5A)
ARG  A 703 (-3.1A)
ARG  A 703 (-2.3A)
ARG  A 703 (-4.5A)
ARG  A 703 ( 3.7A)
ARG  A 703 (-2.6A)
 0.50A 1aq7A-1pq5A:
34.1		 1aq7A-1pq5A:
44.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		4 HIS D 757
SER D 895
VAL D 913
GLY D 916
 None
 0.48A 1aq7A-1pytD:
30.5		 1aq7A-1pytD:
33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		7 HIS A 483
ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 656
GLY A 667
 None
NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.36A 1aq7A-1q3xA:
34.0		 1aq7A-1q3xA:
29.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		5 HIS G  57
ASP G 189
SER G 195
GLY G 216
GLY G 226
 None
 0.74A 1aq7A-1sgfG:
35.9		 1aq7A-1sgfG:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		4 HIS A  57
ASP A 189
SER A 195
GLY A 216
 None
 0.62A 1aq7A-1spjA:
37.4		 1aq7A-1spjA:
42.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1via SHIKIMATE KINASE

(Campylobacter
jejuni) 		PF01202
(SKI) 		4 SER A  15
SER A  18
GLY A  82
GLY A  11
 None
None
SO4  A 176 (-3.4A)
None
 0.69A 1aq7A-1viaA:
undetectable		 1aq7A-1viaA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		7 HIS A  57
ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.45A 1aq7A-1ym0A:
35.9		 1aq7A-1ym0A:
39.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 HIS A 483
SER A 633
VAL A 653
GLY A 656
GLY A 667
 None
 0.58A 1aq7A-1zjkA:
29.3		 1aq7A-1zjkA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 368  A 901 (-4.0A)
368  A 901 (-2.8A)
368  A 901 (-1.4A)
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.44A 1aq7A-1zlrA:
33.5		 1aq7A-1zlrA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix) 		PF00089
(Trypsin) 		4 HIS A  57
ASP A 189
GLY A 216
GLY A 226
 SO4  A 301 (-3.8A)
None
None
None
 0.56A 1aq7A-2aipA:
34.1		 1aq7A-2aipA:
39.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-4.1A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.57A 1aq7A-2eekA:
40.5		 1aq7A-2eekA:
62.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 226
 None
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
 0.61A 1aq7A-2ei8A:
35.6		 1aq7A-2ei8A:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
VAL A 213
GLY A 216
GLY A 226
 None
DT8  A 700 (-3.5A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
 0.48A 1aq7A-2ei8A:
35.6		 1aq7A-2ei8A:
38.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei9 NON-LTR
RETROTRANSPOSON
R1BMKS ORF2 PROTEIN

(Bombyx mori) 		PF14529
(Exo_endo_phos_2) 		5 HIS A 171
SER A 194
VAL A 198
GLY A 219
GLY A 221
 None
 1.32A 1aq7A-2ei9A:
undetectable		 1aq7A-2ei9A:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 227
 None
 0.51A 1aq7A-2f91A:
36.4		 1aq7A-2f91A:
44.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipp CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		5 SER B  90
SER A  39
VAL B  52
GLY B  92
GLY B  99
 None
 1.23A 1aq7A-2ippB:
undetectable		 1aq7A-2ippB:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 HIS B  57
SER C 217
SER C 195
VAL C 213
GLY C 226
 None
 1.03A 1aq7A-2jetB:
14.1		 1aq7A-2jetB:
38.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 SER B 470
GLN B 522
GLY B 529
GLY B 467
 None
 0.66A 1aq7A-2o8eB:
undetectable		 1aq7A-2o8eB:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 HIS A 487
SER A 659
VAL A 677
GLY A 680
 None
 0.60A 1aq7A-2odpA:
21.4		 1aq7A-2odpA:
17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2olg PRO-PHENOLOXIDASE
ACTIVATING ENZYME-I

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		4 HIS A 155
SER A 315
VAL A 334
GLY A 347
 None
 0.34A 1aq7A-2olgA:
26.4		 1aq7A-2olgA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS A  57
ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
BEN  A 245 (-3.0A)
BEN  A 245 (-4.4A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.64A 1aq7A-2oq5A:
34.9		 1aq7A-2oq5A:
37.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A

(Sus scrofa) 		PF00089
(Trypsin) 		4 HIS A  57
ASP B 189
SER B 195
GLY B 216
 None
BEN  B   1 (-3.0A)
BEN  B   1 ( 4.0A)
BEN  B   1 (-3.5A)
 0.57A 1aq7A-2pkaA:
7.5		 1aq7A-2pkaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pks THROMBIN HEAVY CHAIN
FRAGMENT

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP C 229
SER C 235
VAL C 255
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.57A 1aq7A-2pksC:
9.6		 1aq7A-2pksC:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.57A 1aq7A-2psyA:
38.4		 1aq7A-2psyA:
47.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC

(Escherichia
coli) 		PF01032
(FecCD) 		5 SER A  94
SER A 246
VAL A 243
GLY A 254
GLY A  89
 None
 1.36A 1aq7A-2qi9A:
undetectable		 1aq7A-2qi9A:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS B 485
ASP B 631
SER B 637
VAL B 657
GLY B 660
GLY B 668
 None
 0.64A 1aq7A-2qy0B:
31.7		 1aq7A-2qy0B:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.50A 1aq7A-2r0lA:
35.0		 1aq7A-2r0lA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		8 HIS U  57
ASP U 189
SER U 190
GLN U 192
SER U 195
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.53A 1aq7A-2r2wU:
34.4		 1aq7A-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS S  57
ASP S 189
SER S 190
GLN S 192
SER S 195
GLY S 216
GLY S 226
 None
 0.82A 1aq7A-2wpmS:
36.0		 1aq7A-2wpmS:
41.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		4 HIS A 163
SER A 318
VAL A 342
GLY A 356
 None
 0.42A 1aq7A-2xxlA:
26.1		 1aq7A-2xxlA:
26.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS A  59
ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 230
GLY A 240
 None
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.50A 1aq7A-2zecA:
32.4		 1aq7A-2zecA:
40.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 SER A 634
VAL A 601
GLY A 704
GLY A 708
 None
 0.67A 1aq7A-3aqpA:
undetectable		 1aq7A-3aqpA:
14.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		6 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.52A 1aq7A-3beuA:
32.1		 1aq7A-3beuA:
36.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT

(Mus musculus) 		PF00503
(G-alpha) 		4 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.70A 1aq7A-3cx6A:
undetectable		 1aq7A-3cx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT

(Mus musculus) 		PF00503
(G-alpha) 		5 SER A 268
SER A 248
VAL A 247
GLY A  57
GLY A  55
 None
None
None
GDP  A 775 ( 4.2A)
None
 1.24A 1aq7A-3cx6A:
undetectable		 1aq7A-3cx6A:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS H  57
ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.73A 1aq7A-3f6uH:
34.3		 1aq7A-3f6uH:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g01 GRANZYME C

(Mus musculus) 		PF00089
(Trypsin) 		4 HIS A  65
SER A 204
VAL A 218
GLY A 221
 None
 0.47A 1aq7A-3g01A:
31.4		 1aq7A-3g01A:
36.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 SER A 145
VAL A 166
GLY A 160
GLY A 149
 None
 0.71A 1aq7A-3gafA:
undetectable		 1aq7A-3gafA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS B 490
ASP B 640
SER B 646
VAL B 666
GLY B 669
GLY B 679
 None
 0.58A 1aq7A-3govB:
35.1		 1aq7A-3govB:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		7 HIS A  57
ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.73A 1aq7A-3gymA:
35.0		 1aq7A-3gymA:
40.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2s PUTATIVE NADH-FLAVIN
REDUCTASE

(Lactobacillus
paracasei) 		PF13460
(NAD_binding_10) 		5 ASP A 133
SER A  71
VAL A  72
GLY A  75
GLY A  77
 None
NDP  A 301 (-3.2A)
None
None
None
 1.48A 1aq7A-3h2sA:
undetectable		 1aq7A-3h2sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		4 ASP A2570
VAL A2538
GLY A2546
GLY A2548
 None
 0.65A 1aq7A-3javA:
undetectable		 1aq7A-3javA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 HIS A 457
SER A 595
VAL A 613
GLY A 626
 None
 0.49A 1aq7A-3nxpA:
23.2		 1aq7A-3nxpA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5t TCR N30 BETA

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 HIS A  30
SER A  95
VAL A 103
GLY A  98
GLY A 100
 None
 1.29A 1aq7A-3q5tA:
undetectable		 1aq7A-3q5tA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS B  57
ASP B 189
SER B 195
VAL B 213
GLY B 226
 None
 0.66A 1aq7A-3r3gB:
33.5		 1aq7A-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS B  57
ASP B 189
VAL B 213
GLY B 216
GLY B 226
 None
 0.45A 1aq7A-3r3gB:
33.5		 1aq7A-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rp2 RAT MAST CELL
PROTEASE II

(Rattus rattus) 		PF00089
(Trypsin) 		4 HIS A  57
SER A 195
VAL A 213
GLY A 216
 None
 0.52A 1aq7A-3rp2A:
35.0		 1aq7A-3rp2A:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		6 HIS A  56
ASP A 189
SER A 195
VAL A 209
GLY A 212
GLY A 223
 None
 0.59A 1aq7A-3s69A:
34.4		 1aq7A-3s69A:
44.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s9b VIPERA RUSSELLI
PROTEINASE RVV-V
GAMMA

(Daboia
siamensis) 		PF00089
(Trypsin) 		4 HIS A  57
ASP A 189
VAL A 213
GLY A 216
 None
 0.69A 1aq7A-3s9bA:
33.6		 1aq7A-3s9bA:
41.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09272
(Hepsin-SRCR) 		4 HIS A 203
SER A 353
VAL A 375
GLY A 388
 None
 0.35A 1aq7A-3t2nA:
25.5		 1aq7A-3t2nA:
29.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		6 HIS A 836
ASP A 973
SER A 974
SER A 979
GLY A1000
GLY A1010
 None
 0.50A 1aq7A-3w94A:
36.6		 1aq7A-3w94A:
35.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7

(Homo sapiens) 		PF04548
(AIG1) 		4 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.68A 1aq7A-3zjcA:
undetectable		 1aq7A-3zjcA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		5 HIS A 268
ASP A 474
SER A 471
GLY A 455
GLY A 475
 FAD  A1493 (-4.0A)
None
FAD  A1493 (-2.7A)
FAD  A1493 (-3.5A)
None
 1.30A 1aq7A-4at0A:
undetectable		 1aq7A-4at0A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		7 HIS A 211
ASP A 356
GLN A 359
SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.6A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.70A 1aq7A-4bxwA:
33.0		 1aq7A-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7w SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		5 HIS A 129
ASP A 204
GLN A 206
SER A 133
GLY A 139
 None
 1.37A 1aq7A-4d7wA:
undetectable		 1aq7A-4d7wA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.78A 1aq7A-4d9rA:
34.9		 1aq7A-4d9rA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  41
ASP A 181
SER A 182
GLN A 184
GLY A 208
GLY A 218
 None
 0.36A 1aq7A-4dgjA:
36.8		 1aq7A-4dgjA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS A  41
ASP A 181
SER A 182
SER A 187
GLY A 208
GLY A 218
 None
 0.55A 1aq7A-4dgjA:
36.8		 1aq7A-4dgjA:
37.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqu PUTATIVE GLUTATHIONE
TRANSFERASE

(Sphingobium
chlorophenolicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 HIS A 284
ASP A  11
SER A 288
GLY A  85
GLY A   2
 None
 1.27A 1aq7A-4fquA:
undetectable		 1aq7A-4fquA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS H 483
ASP H 627
SER H 628
VAL H 653
GLY H 656
GLY H 667
 None
 0.56A 1aq7A-4fxgH:
32.9		 1aq7A-4fxgH:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		5 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.66A 1aq7A-4gsoA:
undetectable		 1aq7A-4gsoA:
44.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h4f CHYMOTRYPSIN-C

(Homo sapiens) 		PF00089
(Trypsin) 		4 HIS A  57
SER A 195
VAL A 213
GLY A 216
 None
 0.63A 1aq7A-4h4fA:
36.4		 1aq7A-4h4fA:
34.29