SIMILAR PATTERNS OF AMINO ACIDS FOR 1AM6_A_HAEA555_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		4 HIS A  28
LEU A  74
THR A  75
THR A  76
 None
 0.65A 1am6A-1hvyA:
0.0		 1am6A-1hvyA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		4 HIS C 323
LEU C 369
THR C 370
THR C 371
 None
 0.61A 1am6A-1j3jC:
0.0		 1am6A-1j3jC:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
 0.22A 1am6A-1jd0A:
36.3		 1am6A-1jd0A:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 119
HIS A  94
HIS A  96
THR A 200
 ZN  A 901 ( 3.1A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.3A)
 1.05A 1am6A-1jd0A:
36.3		 1am6A-1jd0A:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 HIS A 261
HIS A 244
LEU A 280
THR A 233
 None
 1.03A 1am6A-1ka0A:
0.0		 1am6A-1ka0A:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		7 HIS A  92
HIS A  94
HIS A 111
LEU A 176
THR A 177
THR A 178
TRP A 187
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 0.30A 1am6A-1kopA:
29.8		 1am6A-1kopA:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 HIS A 361
HIS A 541
HIS A 366
LEU A 597
 FE2  A 840 (-3.3A)
FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
RS7  A 841 (-3.4A)
 1.10A 1am6A-1loxA:
0.0		 1am6A-1loxA:
17.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
 0.29A 1am6A-1rj6A:
37.1		 1am6A-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A 119
LEU A 198
THR A 199
 ZN  A 601 ( 3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
 1.09A 1am6A-1rj6A:
37.1		 1am6A-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
None
 0.31A 1am6A-1urtA:
36.9		 1am6A-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
HIS A 119
HIS A  94
THR A 199
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 ( 4.9A)
 1.02A 1am6A-1urtA:
36.9		 1am6A-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		7 HIS A 115
HIS A 117
HIS A 135
LEU A 216
THR A 217
THR A 218
TRP A 227
 ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ZN  A 283 ( 3.1A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
 0.29A 1am6A-1y7wA:
26.1		 1am6A-1y7wA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		6 HIS A 115
HIS A 135
LEU A 216
THR A 217
THR A 218
TRP A 227
 ZN  A 283 ( 3.2A)
ZN  A 283 ( 3.1A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
 1.50A 1am6A-1y7wA:
26.1		 1am6A-1y7wA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yht DSPB

(Aggregatibacter
actinomycetemcomitans) 		PF00728
(Glyco_hydro_20) 		4 HIS A 179
HIS A  51
LEU A 270
THR A 235
 None
 1.04A 1am6A-1yhtA:
undetectable		 1am6A-1yhtA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 HIS A  18
LEU A  66
THR A  67
THR A  68
 None
 0.67A 1am6A-2aazA:
undetectable		 1am6A-2aazA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flq NITRIC OXIDE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF02898
(NO_synthase) 		4 HIS A 307
HIS A 308
THR A 343
THR A 344
 None
 1.05A 1am6A-2flqA:
undetectable		 1am6A-2flqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		4 HIS A  88
LEU A  98
THR A  95
THR A  94
 PO4  A 501 ( 4.9A)
None
None
None
 1.03A 1am6A-2hekA:
undetectable		 1am6A-2hekA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.21A 1am6A-2it4A:
40.7		 1am6A-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 HIS A 235
LEU A 281
THR A 282
THR A 283
 None
 0.63A 1am6A-2oipA:
undetectable		 1am6A-2oipA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 HIS A 235
LEU A 281
THR A 282
THR A 283
 None
 0.92A 1am6A-2oipA:
undetectable		 1am6A-2oipA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		4 HIS A 237
HIS A 235
HIS A 255
LEU A 202
 MET  A 600 (-3.9A)
MET  A 600 (-4.4A)
MET  A 600 ( 4.3A)
MET  A 600 (-3.7A)
 0.87A 1am6A-2qs8A:
undetectable		 1am6A-2qs8A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		4 HIS A 255
HIS A 237
HIS A 235
LEU A 202
 MET  A 600 ( 4.3A)
MET  A 600 (-3.9A)
MET  A 600 (-4.4A)
MET  A 600 (-3.7A)
 0.97A 1am6A-2qs8A:
undetectable		 1am6A-2qs8A:
23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 118
HIS A 141
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
 0.27A 1am6A-2w2jA:
37.1		 1am6A-2w2jA:
38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
ZN  A   1 ( 4.7A)
None
None
 0.28A 1am6A-2zncA:
32.1		 1am6A-2zncA:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 HIS A 119
HIS A  94
HIS A  96
THR A 200
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
 1.02A 1am6A-2zncA:
32.1		 1am6A-2zncA:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ah5 THYMIDYLATE SYNTHASE
THYX

(Helicobacter
pylori) 		PF02511
(Thy1) 		4 HIS A 231
HIS A 234
LEU A 196
THR A 195
 None
SO4  A  10 (-4.7A)
FAD  A 240 (-4.4A)
None
 1.09A 1am6A-3ah5A:
undetectable		 1am6A-3ah5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 HIS A 163
HIS A 165
HIS A 182
LEU A 259
THR A 260
THR A 261
TRP A 270
 ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 (-3.1A)
None
ZN  A 378 ( 4.5A)
None
None
 0.24A 1am6A-3b1bA:
24.9		 1am6A-3b1bA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b47 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Geobacter
sulfurreducens) 		no annotation 4 HIS A 119
LEU A  82
THR A 156
THR A 157
 None
 1.01A 1am6A-3b47A:
undetectable		 1am6A-3b47A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5o CADD-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF12981
(DUF3865) 		4 HIS A 178
HIS A  94
THR A  89
THR A  88
 None
 1.07A 1am6A-3b5oA:
undetectable		 1am6A-3b5oA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  95
HIS A  97
HIS A 120
LEU A 199
THR A 200
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 0.40A 1am6A-3da2A:
42.0		 1am6A-3da2A:
59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 111
HIS A 113
HIS A 138
LEU A 219
THR A 220
TRP A 230
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
 0.70A 1am6A-3fe4A:
31.3		 1am6A-3fe4A:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 113
HIS A 138
HIS A 111
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
MG  A 901 (-3.4A)
None
 0.97A 1am6A-3fe4A:
31.3		 1am6A-3fe4A:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 LEU A 219
THR A 220
THR A 221
TRP A 230
 None
 0.44A 1am6A-3fe4A:
31.3		 1am6A-3fe4A:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 129
LEU A 235
THR A 236
TRP A 246
 None
 0.28A 1am6A-3jxfA:
33.6		 1am6A-3jxfA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgb THYMIDYLATE SYNTHASE
1/2

(Encephalitozoon
cuniculi) 		PF00303
(Thymidylat_synt) 		4 HIS A   7
LEU A  54
THR A  55
THR A  56
 None
 0.66A 1am6A-3kgbA:
undetectable		 1am6A-3kgbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 HIS A 226
LEU A 272
THR A 273
THR A 274
 None
 0.59A 1am6A-3kjrA:
undetectable		 1am6A-3kjrA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8r PUTATIVE PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIA COMPONENT

(Streptococcus
mutans) 		PF02255
(PTS_IIA) 		4 HIS A  82
LEU A  89
THR A  86
THR A  85
 None
 0.85A 1am6A-3l8rA:
undetectable		 1am6A-3l8rA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 0.17A 1am6A-3ml5A:
42.5		 1am6A-3ml5A:
55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 119
HIS A  94
HIS A  96
THR A 200
 ZN  A 263 ( 3.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.5A)
 1.02A 1am6A-3ml5A:
42.5		 1am6A-3ml5A:
55.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		4 HIS A  22
LEU A 106
THR A 103
THR A 102
 None
 0.78A 1am6A-3npkA:
undetectable		 1am6A-3npkA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb0 DIHYDRODIPICOLINATE
SYNTHASE

(Thermotoga
maritima) 		PF00701
(DHDPS) 		4 HIS A 117
LEU A  85
THR A  81
THR A  84
 None
 0.94A 1am6A-3pb0A:
undetectable		 1am6A-3pb0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 HIS A 117
HIS A  93
LEU A 211
THR A  49
 None
 1.02A 1am6A-3pkjA:
undetectable		 1am6A-3pkjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 HIS A  31
LEU A 120
THR A 117
THR A 116
 None
 0.79A 1am6A-3q1oA:
undetectable		 1am6A-3q1oA:
23.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		7 HIS A 123
HIS A 125
HIS A 142
LEU A 214
THR A 215
THR A 216
TRP A 225
 ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 3.2A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
 0.35A 1am6A-3q31A:
24.3		 1am6A-3q31A:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 HIS A 323
LEU A 369
THR A 370
THR A 371
 None
 0.58A 1am6A-3um6A:
undetectable		 1am6A-3um6A:
17.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
HIS A 119
THR A 198
THR A 199
TRP A 208
 ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
ZN  A 261 ( 4.4A)
None
None
 0.33A 1am6A-3uyqA:
40.8		 1am6A-3uyqA:
58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 119
HIS A  94
HIS A  96
THR A 199
 ZN  A 261 (-3.2A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
 1.02A 1am6A-3uyqA:
40.8		 1am6A-3uyqA:
58.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 HIS A 313
HIS A 333
LEU A  27
THR A  28
 None
 1.05A 1am6A-3wiqA:
undetectable		 1am6A-3wiqA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 491
HIS A 633
HIS A 602
THR A 623
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.3A)
CUO  A9002 (-3.4A)
CUO  A9002 ( 4.5A)
 1.10A 1am6A-4bedA:
undetectable		 1am6A-4bedA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2974
HIS B3106
HIS B3075
LEU B3093
 CUO  B9008 (-2.9A)
CUO  B9008 (-3.3A)
CUO  B9008 (-2.8A)
None
 0.97A 1am6A-4bedB:
undetectable		 1am6A-4bedB:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 HIS A  75
HIS A  73
HIS A 107
THR A 253
 None
 1.08A 1am6A-4cnsA:
undetectable		 1am6A-4cnsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 HIS A  75
HIS A  73
HIS A 107
THR A 253
 None
 1.10A 1am6A-4cntA:
undetectable		 1am6A-4cntA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 HIS A 242
HIS A 164
LEU A 239
THR A 240
 None
 0.99A 1am6A-4dyjA:
undetectable		 1am6A-4dyjA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		7 HIS A  89
HIS A  91
HIS A 108
LEU A 173
THR A 174
THR A 175
TRP A 184
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
 0.24A 1am6A-4g7aA:
29.9		 1am6A-4g7aA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		4 HIS A  91
HIS A 108
HIS A  89
THR A 174
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.4A)
 1.07A 1am6A-4g7aA:
29.9		 1am6A-4g7aA:
34.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 HIS B  -2
LEU B  56
THR B  55
THR B  22
 None
 1.02A 1am6A-4ii2B:
undetectable		 1am6A-4ii2B:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 HIS A 120
HIS A  48
HIS A 234
TRP A 148
 None
 0.63A 1am6A-4jqsA:
undetectable		 1am6A-4jqsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		4 HIS A 101
HIS A  34
LEU A 196
THR A 192
 None
 1.05A 1am6A-4k3fA:
undetectable		 1am6A-4k3fA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 HIS A 127
HIS A 126
HIS A 171
TRP A 224
 None
GOL  A 622 (-3.3A)
GOL  A 622 (-4.2A)
GOL  A 622 (-4.5A)
 0.84A 1am6A-4pspA:
undetectable		 1am6A-4pspA:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  64
THR A 200
THR A 199
TRP A   5
 None
None
ZN  A 301 ( 4.4A)
None
 1.08A 1am6A-4qk3A:
43.3		 1am6A-4qk3A:
95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
None
 0.22A 1am6A-4qk3A:
43.3		 1am6A-4qk3A:
95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
None
 1.46A 1am6A-4qk3A:
43.3		 1am6A-4qk3A:
95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 119
HIS A  94
HIS A  96
THR A 200
 ZN  A 301 (-3.1A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
 1.02A 1am6A-4qk3A:
43.3		 1am6A-4qk3A:
95.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r42 ALR3090 PROTEIN

(Nostoc sp. PCC
7120) 		PF05067
(Mn_catalase) 		4 HIS A  79
LEU A 156
THR A 152
THR A 155
 None
 1.08A 1am6A-4r42A:
undetectable		 1am6A-4r42A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		4 HIS A  87
THR A 199
THR A 198
TRP A  26
 CL  A 304 ( 4.9A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.94A 1am6A-4uovA:
31.2		 1am6A-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		7 HIS A 112
HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.26A 1am6A-4uovA:
31.2		 1am6A-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		4 HIS A 114
HIS A 131
HIS A 112
THR A 198
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 (-3.2A)
AZM  A 299 (-3.3A)
 1.07A 1am6A-4uovA:
31.2		 1am6A-4uovA:
36.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		4 HIS B 942
HIS B 937
HIS B 744
THR B 732
 ZN  B1101 (-3.2A)
ZN  B1101 (-3.2A)
None
None
 0.82A 1am6A-4wwxB:
undetectable		 1am6A-4wwxB:
16.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		7 HIS A  89
HIS A  91
HIS A 108
LEU A 173
THR A 174
THR A 175
TRP A 184
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 0.23A 1am6A-4x5sA:
29.8		 1am6A-4x5sA:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		6 HIS A 110
HIS A 112
HIS A 129
LEU A 190
THR A 191
TRP A 201
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 ( 3.1A)
None
ZN  A 301 (-4.3A)
None
 0.35A 1am6A-4xfwA:
26.4		 1am6A-4xfwA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 HIS A 160
HIS A 162
HIS A 179
LEU A 253
THR A 254
THR A 255
TRP A 264
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 0.22A 1am6A-4xixA:
25.7		 1am6A-4xixA:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		7 HIS A 165
HIS A 167
HIS A 184
LEU A 251
THR A 252
THR A 253
TRP A 262
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.1A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 0.32A 1am6A-4xz5A:
29.7		 1am6A-4xz5A:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		4 HIS A 184
HIS A 165
HIS A 167
THR A 253
 ZN  A 401 ( 3.1A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
BCT  A 402 ( 4.4A)
 1.09A 1am6A-4xz5A:
29.7		 1am6A-4xz5A:
32.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 HIS A 285
HIS A 321
HIS A 287
THR A 391
 KCX  A 191 ( 3.7A)
KCX  A 191 ( 3.5A)
KCX  A 191 ( 4.0A)
KCX  A 191 ( 2.9A)
 0.96A 1am6A-5c2cA:
undetectable		 1am6A-5c2cA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
 0.25A 1am6A-5cjfA:
36.3		 1am6A-5cjfA:
36.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e32 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 HIS A 295
LEU A 300
THR A 283
THR A 301
 None
 1.09A 1am6A-5e32A:
undetectable		 1am6A-5e32A:
24.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 151
LEU A 256
THR A 257
THR A 258
TRP A 267
 None
 0.36A 1am6A-5e5uA:
34.2		 1am6A-5e5uA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		7 HIS X  93
HIS X  95
HIS X 118
LEU X 196
THR X 197
THR X 198
TRP X 207
 ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
ZN  X 301 (-3.1A)
None
ZN  X 301 ( 4.4A)
None
None
 0.24A 1am6A-5eztX:
43.8		 1am6A-5eztX:
80.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3a ORF70

(Human
gammaherpesvirus
8) 		PF00303
(Thymidylat_synt) 		4 HIS A  52
LEU A  98
THR A  99
THR A 100
 None
 0.69A 1am6A-5h3aA:
undetectable		 1am6A-5h3aA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		7 HIS A  96
HIS A  98
HIS A 115
LEU A 181
THR A 182
THR A 183
TRP A 192
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
None
 0.36A 1am6A-5hpjA:
29.3		 1am6A-5hpjA:
35.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		5 HIS A  98
HIS A  96
THR A 183
THR A 182
TRP A  15
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
 1.40A 1am6A-5hpjA:
29.3		 1am6A-5hpjA:
35.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		4 HIS A 115
HIS A  98
THR A 182
THR A  40
 ZN  A 301 (-3.1A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.4A)
None
 0.94A 1am6A-5hpjA:
29.3		 1am6A-5hpjA:
35.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 HIS A 286
HIS A 322
HIS A 288
THR A 392
 KCX  A 192 ( 3.5A)
KCX  A 192 (-3.8A)
CAP  A 500 (-3.9A)
KCX  A 192 ( 3.1A)
 0.91A 1am6A-5hqlA:
undetectable		 1am6A-5hqlA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 603
THR B 599
THR B 602
TRP B 561
 None
 1.02A 1am6A-5ip9B:
undetectable		 1am6A-5ip9B:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		4 HIS A 121
LEU A  96
THR A  93
THR A  92
 PLP  A 501 ( 3.5A)
None
PLP  A 501 (-3.5A)
PLP  A 501 (-3.9A)
 0.89A 1am6A-5j8qA:
undetectable		 1am6A-5j8qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		4 HIS A 121
LEU A  96
THR A  93
THR A  92
 PLP  A 501 ( 3.5A)
None
PLP  A 501 (-3.5A)
PLP  A 501 (-3.9A)
 1.05A 1am6A-5j8qA:
undetectable		 1am6A-5j8qA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 0.25A 1am6A-5jn9A:
33.4		 1am6A-5jn9A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 119
HIS A  94
HIS A  96
THR A 200
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.9A)
 1.05A 1am6A-5jn9A:
33.4		 1am6A-5jn9A:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		4 HIS A 238
HIS A 183
HIS A 304
THR A 136
 FE2  A 502 (-4.5A)
FE2  A 502 (-4.0A)
FE2  A 502 (-3.8A)
None
 0.96A 1am6A-5kjaA:
undetectable		 1am6A-5kjaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		4 HIS A 238
HIS A 183
LEU A 483
THR A 136
 FE2  A 502 (-4.5A)
FE2  A 502 (-4.0A)
None
None
 1.07A 1am6A-5kjaA:
undetectable		 1am6A-5kjaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER

(Aequorea
victoria;
Mus musculus) 		PF00452
(Bcl-2)
PF01353
(GFP) 		4 HIS A 181
LEU A  60
THR A  62
THR A  63
 None
 1.00A 1am6A-5ktgA:
undetectable		 1am6A-5ktgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 HIS A 286
HIS A 322
HIS A 288
THR A 422
 KCX  A 193 ( 4.3A)
CAP  A 501 (-4.0A)
CAP  A 501 (-3.8A)
KCX  A 193 ( 3.7A)
 0.80A 1am6A-5macA:
undetectable		 1am6A-5macA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 HIS A 498
LEU A 551
THR A 548
THR A 547
 None
 0.82A 1am6A-5zqzA:
undetectable		 1am6A-5zqzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM
V-TYPE PROTON ATPASE
SUBUNIT C''

(Saccharomyces
cerevisiae) 		no annotation 4 LEU C 101
THR C  98
THR C  97
TRP A 802
 None
 0.86A 1am6A-6c6lC:
undetectable		 1am6A-6c6lC:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 4 HIS A 942
HIS A 937
HIS A 744
THR A 732
 ZN  A1101 (-3.3A)
ZN  A1101 (-3.4A)
None
None
 0.79A 1am6A-6cg0A:
undetectable		 1am6A-6cg0A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 7 HIS A 117
HIS A 119
HIS A 136
LEU A 201
THR A 202
THR A 203
TRP A 212
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 301 (-4.4A)
None
None
 0.21A 1am6A-6ekiA:
29.8		 1am6A-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 5 HIS A 119
HIS A 117
THR A 203
THR A 202
TRP A  33
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
ZN  A 301 (-4.4A)
None
 1.48A 1am6A-6ekiA:
29.8		 1am6A-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 4 HIS A 119
HIS A 136
HIS A 117
THR A 202
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-4.4A)
 1.10A 1am6A-6ekiA:
29.8		 1am6A-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 4 HIS A 136
HIS A 117
HIS A 119
THR A 203
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
 1.06A 1am6A-6ekiA:
29.8		 1am6A-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 7 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 0.36A 1am6A-6fe1A:
33.6		 1am6A-6fe1A:
14.90