SIMILAR PATTERNS OF AMINO ACIDS FOR 1ALZ_B_DVAB8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		4 VAL A 262
TRP A 225
VAL A 175
TRP A 237
 None
 1.39A 1alzA-2rjoA:
undetectable
1alzB-2rjoA:
undetectable		 1alzA-2rjoA:
3.54
1alzB-2rjoA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Chaetomium
thermophilum) 		PF08662
(eIF2A) 		4 VAL A 194
TRP A 206
VAL A 172
TRP A 183
 None
 1.27A 1alzA-4noxA:
undetectable
1alzB-4noxA:
undetectable		 1alzA-4noxA:
1.90
1alzB-4noxA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF08662
(eIF2A) 		4 VAL A 502
TRP A 515
VAL A 463
TRP A 499
 None
 1.25A 1alzA-4u1fA:
undetectable
1alzB-4u1fA:
undetectable		 1alzA-4u1fA:
1.97
1alzB-4u1fA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT

(Aquifex
aeolicus) 		PF02091
(tRNA-synt_2e) 		4 VAL A 155
TRP A  48
TRP A  14
VAL A  79
 None
 1.50A 1alzA-5f5wA:
undetectable
1alzB-5f5wA:
undetectable		 1alzA-5f5wA:
5.69
1alzB-5f5wA:
7.10