SIMILAR PATTERNS OF AMINO ACIDS FOR 1ALZ_A_DVAA6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g19 GLUTATHIONE
TRANSFERASE GTE1

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 ALA A 216
VAL A 214
TRP A  26
TRP A 220
 None
None
None
GOL  A 303 (-4.7A)
 1.43A 1alzA-4g19A:
undetectable
1alzB-4g19A:
undetectable		 1alzA-4g19A:
5.02
1alzB-4g19A:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 ALA A 217
VAL A 215
TRP A  26
TRP A 221
 None
 1.43A 1alzA-4lmvA:
undetectable
1alzB-4lmvA:
undetectable		 1alzA-4lmvA:
5.85
1alzB-4lmvA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		4 ALA A 103
VAL A 105
TRP A 407
TRP A  66
 None
 1.46A 1alzA-5xd0A:
undetectable
1alzB-5xd0A:
undetectable		 1alzA-5xd0A:
2.70
1alzB-5xd0A:
2.49