SIMILAR PATTERNS OF AMINO ACIDS FOR 1AL4_A_DVAA8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)

(Thermotoga
maritima) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 VAL A 154
TRP A 125
VAL A 123
TRP A 157
 None
 1.50A 1al4A-1c3cA:
undetectable
1al4B-1c3cA:
undetectable		 1al4A-1c3cA:
4.36
1al4B-1c3cA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 VAL A1059
TRP A1030
VAL A1028
TRP A1032
 None
 1.37A 1al4A-1lu4A:
undetectable
1al4B-1lu4A:
undetectable		 1al4A-1lu4A:
6.47
1al4B-1lu4A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i04 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		4 VAL A 279
TRP A 286
VAL A 305
TRP A 277
 EDO  A 402 (-4.1A)
None
None
None
 1.27A 1al4A-4i04A:
undetectable
1al4B-4i04A:
undetectable		 1al4A-4i04A:
4.83
1al4B-4i04A:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i05 CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		4 VAL A 279
TRP A 286
VAL A 305
TRP A 277
 None
 1.37A 1al4A-4i05A:
undetectable
1al4B-4i05A:
undetectable		 1al4A-4i05A:
5.10
1al4B-4i05A:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf9 HEMIN DEGRADING
FACTOR

(Pseudomonas
aeruginosa) 		PF05171
(HemS) 		4 VAL A 305
TRP A 344
VAL A 314
TRP A 317
 None
None
HEM  A 400 ( 4.9A)
None
 1.47A 1al4A-4mf9A:
undetectable
1al4B-4mf9A:
undetectable		 1al4A-4mf9A:
4.30
1al4B-4mf9A:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT

(Aquifex
aeolicus) 		PF02091
(tRNA-synt_2e) 		4 VAL A  79
VAL A 155
TRP A  48
TRP A  14
 None
 1.24A 1al4A-5f5wA:
undetectable
1al4B-5f5wA:
undetectable		 1al4A-5f5wA:
7.10
1al4B-5f5wA:
7.10