SIMILAR PATTERNS OF AMINO ACIDS FOR 1AL4_A_DVAA6_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A

([Haemophilus]
ducreyi) 		PF03498
(CDtoxinA) 		4 ALA A 101
VAL A  90
TRP A  91
TRP A 116
 None
 1.48A 1al4A-1sr4A:
undetectable
1al4B-1sr4A:
undetectable		 1al4A-1sr4A:
7.69
1al4B-1sr4A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 ALA A  23
VAL A  25
TRP A  55
TRP A  18
 GOL  A 441 ( 3.7A)
None
None
IMD  A 437 (-3.4A)
 1.25A 1al4A-3cc1A:
undetectable
1al4B-3cc1A:
undetectable		 1al4A-3cc1A:
4.58
1al4B-3cc1A:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyy RESPONSE REGULATOR

(Xanthomonas
campestris) 		PF00990
(GGDEF) 		4 ALA A 159
VAL A 157
TRP A 209
TRP A 165
 None
 1.43A 1al4A-3qyyA:
undetectable
1al4B-3qyyA:
undetectable		 1al4A-3qyyA:
13.25
1al4B-3qyyA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu9 BETA-GALACTOSIDASE

(Streptococcus
pneumoniae) 		no annotation 4 ALA A1876
VAL A1878
TRP A1975
TRP A1861
 None
 1.25A 1al4A-4cu9A:
undetectable
1al4B-4cu9A:
undetectable		 1al4A-4cu9A:
7.58
1al4B-4cu9A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 ALA A 217
VAL A 215
TRP A  26
TRP A 221
 None
 1.49A 1al4A-4lmvA:
undetectable
1al4B-4lmvA:
undetectable		 1al4A-4lmvA:
9.17
1al4B-4lmvA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yla AROMATIC
PRENYLTRANSFERASE

(Marinactinospora
thermotolerans) 		PF11991
(Trp_DMAT) 		4 ALA A 108
TRP A 123
TRP A  77
TRP A  67
 None
 1.47A 1al4A-4ylaA:
undetectable
1al4B-4ylaA:
undetectable		 1al4A-4ylaA:
18.64
1al4B-4ylaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		4 ALA A 407
VAL A 373
TRP A 376
TRP A 535
 None
 1.10A 1al4A-5axhA:
undetectable
1al4B-5axhA:
undetectable		 1al4A-5axhA:
2.52
1al4B-5axhA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ALA A 429
VAL A 531
TRP A 512
TRP A 420
 None
 1.27A 1al4A-5lm8A:
undetectable
1al4B-5lm8A:
undetectable		 1al4A-5lm8A:
2.78
1al4B-5lm8A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		4 ALA A 103
VAL A 105
TRP A 407
TRP A  66
 None
 1.46A 1al4A-5xd0A:
undetectable
1al4B-5xd0A:
undetectable		 1al4A-5xd0A:
2.49
1al4B-5xd0A:
2.49