SIMILAR PATTERNS OF AMINO ACIDS FOR 1AGM_A_ACRA496_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2n CAPSID PROTEIN

(Rice yellow
mottle virus) 		PF00729
(Viral_coat) 		4 SER A 189
TRP A  98
LEU A  63
TRP A 103
 None
 1.47A 1agmA-1f2nA:
undetectable		 1agmA-1f2nA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 TRP A 437
GLU A 438
LEU A 652
TRP A 654
 ACR  A 700 (-4.8A)
ACR  A 700 (-3.5A)
None
None
 0.48A 1agmA-1lf9A:
29.7		 1agmA-1lf9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A) 		PF00073
(Rhv) 		4 SER 2 198
GLU 1  38
LEU 1  34
TRP 3 155
 None
 1.42A 1agmA-1r1a2:
undetectable		 1agmA-1r1a2:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 TRP A 429
GLU A 430
LEU A 653
TRP A 655
 ACR  A3000 (-4.9A)
ACR  A3000 (-3.6A)
None
None
 0.42A 1agmA-1ulvA:
31.7		 1agmA-1ulvA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		4 SER A 282
TRP A 217
LEU A 275
TRP A 262
 None
 1.20A 1agmA-2dh3A:
undetectable		 1agmA-2dh3A:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 TRP A 209
GLU A 210
LEU A 471
TRP A 473
 None
ACR  A 995 (-3.7A)
None
None
 0.16A 1agmA-2f6dA:
45.9		 1agmA-2f6dA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		4 TRP A 178
GLU A 179
LEU A 419
TRP A 421
 None
BTB  A 620 (-3.6A)
None
None
 0.37A 1agmA-2vn7A:
62.4		 1agmA-2vn7A:
47.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		4 SER A 265
TRP A 485
GLU A 488
LEU A 225
 None
 1.48A 1agmA-3ckbA:
undetectable		 1agmA-3ckbA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		5 SER A 143
TRP A 202
GLU A 203
LEU A 439
TRP A 441
 None
None
TRS  A 701 ( 3.8A)
None
None
 0.57A 1agmA-3eqaA:
70.0		 1agmA-3eqaA:
95.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 SER A 390
TRP A 653
GLU A 651
LEU A 620
 None
 1.40A 1agmA-3o8oA:
undetectable		 1agmA-3o8oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 SER A 595
GLU A 662
LEU A 611
TRP A 614
 None
 1.50A 1agmA-4cgtA:
undetectable		 1agmA-4cgtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2) 		4 SER E 119
GLU E 108
LEU E 102
TRP E  63
 None
 1.47A 1agmA-4f52E:
undetectable		 1agmA-4f52E:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k00 1,4-DIHYDROXY-2-NAPH
THOYL-COA HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF03061
(4HBT) 		4 SER A  62
TRP A  37
LEU A 124
TRP A 128
 None
 1.26A 1agmA-4k00A:
undetectable		 1agmA-4k00A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7k HYPOTHETICAL PROTEIN
JHP0584

(Helicobacter
pylori) 		no annotation 4 TRP A  99
GLU A 133
LEU A 159
TRP A 158
 None
 1.44A 1agmA-4r7kA:
undetectable		 1agmA-4r7kA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejs MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF09380
(FERM_C) 		4 SER A1919
GLU A1956
LEU A1856
TRP A1859
 None
 1.40A 1agmA-5ejsA:
undetectable		 1agmA-5ejsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 SER A 915
TRP A 962
LEU A 949
TRP A 890
 None
 1.42A 1agmA-5t8vA:
2.8		 1agmA-5t8vA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 SER A 294
TRP A 362
GLU A  31
LEU A 472
 None
 1.44A 1agmA-5wu7A:
undetectable		 1agmA-5wu7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 4 TRP A 212
GLU A 213
LEU A 451
TRP A 453
 None
B3P  A 652 (-3.7A)
None
None
 0.25A 1agmA-6fhvA:
62.7		 1agmA-6fhvA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 TRP A 207
GLU A 208
LEU A 447
TRP A 449
 None
ACR  A 801 (-3.9A)
None
None
 0.27A 1agmA-6fhwA:
60.6		 1agmA-6fhwA:
10.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 5 SER A 143
TRP A 202
GLU A 203
LEU A 439
TRP A 441
 None
 0.27A 1agmA-6frvA:
68.5		 1agmA-6frvA:
83.87