SIMILAR PATTERNS OF AMINO ACIDS FOR 1AFS_A_TESA325_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cau CANAVALIN

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		4 LEU B 265
TYR B 258
THR B 269
ASN B 299
 None
 0.99A 1afsA-1cauB:
undetectable		 1afsA-1cauB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgr CANAVALIN

(Canavalia
ensiformis) 		no annotation 4 LEU X 265
TYR X 258
THR X 269
ASN X 299
 None
None
None
PO4  X1500 (-3.2A)
 1.04A 1afsA-1dgrX:
0.0		 1afsA-1dgrX:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 4 LEU B 599
TYR B 600
THR B 734
TYR B 721
 None
 1.09A 1afsA-1ej6B:
0.0		 1afsA-1ej6B:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		4 LEU A 354
THR A  72
ASN A  77
TYR A 259
 None
 1.28A 1afsA-1hlgA:
0.0		 1afsA-1hlgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 LEU A 140
TYR A 204
TRP A 135
ASN A  89
 None
 1.25A 1afsA-1k0fA:
0.4		 1afsA-1k0fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 TYR A 339
THR A 388
ASN A 235
TYR A 207
 None
 1.31A 1afsA-1mdfA:
0.5		 1afsA-1mdfA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		4 LEU A 963
TYR A 814
HIS A 961
ASN A 581
 None
 1.14A 1afsA-1no7A:
0.0		 1afsA-1no7A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		4 LEU A 385
TYR A 386
THR A 323
TRP A 326
 None
 1.37A 1afsA-1phzA:
0.0		 1afsA-1phzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		4 LEU A 218
TYR A 220
ASN A 138
TYR A 177
 None
 1.05A 1afsA-1r8yA:
0.0		 1afsA-1r8yA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ral 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 LEU A  54
TYR A  55
HIS A 117
ASN A 306
 None
 0.76A 1afsA-1ralA:
42.7		 1afsA-1ralA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ral 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 LEU A  54
TYR A  55
HIS A 117
THR A 226
 None
 0.82A 1afsA-1ralA:
42.7		 1afsA-1ralA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 LEU A 140
TYR A 204
TRP A 135
ASN A  89
 None
 1.31A 1afsA-1toaA:
undetectable		 1afsA-1toaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		4 LEU A 376
TYR A 369
THR A 380
ASN A 410
 None
 1.11A 1afsA-1uikA:
undetectable		 1afsA-1uikA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 LEU A 381
HIS A 384
THR A 336
ASN A 341
 None
NAG  A1701 ( 4.1A)
None
None
 1.29A 1afsA-1ukcA:
undetectable		 1afsA-1ukcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		4 LEU A  21
TYR A 260
ASN A 151
TYR A 268
 None
 1.04A 1afsA-1wiwA:
undetectable		 1afsA-1wiwA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		4 LEU B  24
HIS C 453
THR C  67
ASN C 244
 None
 1.17A 1afsA-2advB:
undetectable		 1afsA-2advB:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cav PROTEIN (CANAVALIN)

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		4 LEU A 265
TYR A 258
THR A 269
ASN A 299
 None
 1.04A 1afsA-2cavA:
undetectable		 1afsA-2cavA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 LEU A 167
TYR A  83
HIS A 171
THR A 201
 None
 1.26A 1afsA-2d0jA:
undetectable		 1afsA-2d0jA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3

(Salmonella
enterica) 		PF00669
(Flagellin_N) 		4 LEU A 250
HIS A 174
THR A  84
ASN A 242
 None
 1.38A 1afsA-2d4xA:
undetectable		 1afsA-2d4xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnu AMINOTRANSFERASE

(Helicobacter
pylori) 		PF01041
(DegT_DnrJ_EryC1) 		4 TYR A 316
HIS A 157
THR A  79
ASN A 108
 UD1  A 902 ( 4.5A)
PMP  A 901 (-3.9A)
None
None
 1.30A 1afsA-2fnuA:
undetectable		 1afsA-2fnuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzo UPF0301 PROTEIN
SO3346

(Shewanella
oneidensis) 		PF02622
(DUF179) 		4 LEU A 103
HIS A 154
ASN A   6
TYR A  26
 None
 0.92A 1afsA-2gzoA:
undetectable		 1afsA-2gzoA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqb TRANSCRIPTIONAL
ACTIVATOR OF COMK
GENE

(Bacillus
halodurans) 		PF02608
(Bmp) 		4 LEU A 227
TYR A 228
THR A  97
ASN A  88
 None
 1.13A 1afsA-2hqbA:
undetectable		 1afsA-2hqbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 LEU A 102
HIS A 163
THR B 152
ASN B  73
 None
 1.19A 1afsA-2incA:
undetectable		 1afsA-2incA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		4 TYR A 127
HIS A 107
THR A 115
ASN A 286
 FE2  A1326 ( 4.4A)
FE2  A1326 ( 3.4A)
None
None
 1.08A 1afsA-2ivpA:
undetectable		 1afsA-2ivpA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 TYR A 989
THR A1366
ASN A1373
TYR A1215
 None
 1.26A 1afsA-2nlkA:
undetectable		 1afsA-2nlkA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 TYR A 310
HIS A 326
THR A 250
ASN A 289
 None
 1.38A 1afsA-2qpsA:
5.8		 1afsA-2qpsA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		4 LEU A 316
TYR A 320
HIS A 309
THR A 410
 None
 1.33A 1afsA-2radA:
undetectable		 1afsA-2radA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 LEU M 103
TYR M 104
HIS M 688
THR M 117
 None
 1.39A 1afsA-2w4gM:
undetectable		 1afsA-2w4gM:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzv NFNB PROTEIN

(Mycolicibacterium
smegmatis) 		PF00881
(Nitroreductase) 		4 LEU A 116
TYR A 113
THR A 131
TYR A 137
 None
 1.12A 1afsA-2wzvA:
undetectable		 1afsA-2wzvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		4 LEU A  86
HIS A  85
ASN A 127
TYR A 185
 None
 0.84A 1afsA-2x63A:
undetectable		 1afsA-2x63A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		4 LEU A 454
TYR A 937
HIS A 415
TYR A 891
 None
 0.99A 1afsA-2yocA:
5.6		 1afsA-2yocA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		4 LEU A 159
TYR A 139
HIS A 221
TYR A 224
 None
 1.37A 1afsA-3c2uA:
undetectable		 1afsA-3c2uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		4 LEU A 203
HIS A 207
ASN A 132
TYR A 259
 None
 0.93A 1afsA-3caxA:
undetectable		 1afsA-3caxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LEU A  81
THR A 437
TRP A 436
ASN A 151
 None
 1.10A 1afsA-3ce6A:
undetectable		 1afsA-3ce6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPI

(Escherichia
coli) 		PF02501
(T2SSI) 		4 LEU I  51
TYR I  52
THR I  83
TRP I 111
 None
 1.11A 1afsA-3ci0I:
undetectable		 1afsA-3ci0I:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		4 LEU A 132
HIS A 137
THR A 150
TYR A 164
 None
 1.29A 1afsA-3d8uA:
undetectable		 1afsA-3d8uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e18 OXIDOREDUCTASE

(Listeria
innocua) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A  21
TYR A 306
HIS A  18
TRP A 125
 None
 1.27A 1afsA-3e18A:
undetectable		 1afsA-3e18A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11)
PF14710
(Nitr_red_alph_N)
PF14711
(Nitr_red_bet_C) 		4 LEU A1110
HIS B  20
THR B  31
ASN B  42
 None
None
None
SF4  B 803 (-4.9A)
 1.36A 1afsA-3egwA:
undetectable		 1afsA-3egwA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00814
(Peptidase_M22) 		4 TYR A 128
HIS A 107
THR A 278
ASN A 286
 MG  A 600 (-4.8A)
MG  A 600 (-3.9A)
None
None
 1.35A 1afsA-3enoA:
undetectable		 1afsA-3enoA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU B 540
TYR B 544
HIS B 493
THR B 665
 None
 1.21A 1afsA-3govB:
undetectable		 1afsA-3govB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 446
TYR A 423
HIS A 443
THR A 270
 None
 1.28A 1afsA-3h11A:
undetectable		 1afsA-3h11A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LEU A  64
THR A 373
TRP A 372
ASN A 125
 None
 1.11A 1afsA-3h9uA:
undetectable		 1afsA-3h9uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA

(Bacillus
subtilis) 		PF01510
(Amidase_2) 		4 LEU A  69
HIS A  57
TRP A  76
ASN A  86
 None
 1.20A 1afsA-3hmbA:
undetectable		 1afsA-3hmbA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 LEU A 135
THR A 174
TRP A 138
TYR A  76
 None
None
None
PLM  A 563 (-4.5A)
 1.23A 1afsA-3ib3A:
undetectable		 1afsA-3ib3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 4 LEU A 243
HIS A 247
THR A 226
ASN A 214
 None
 1.26A 1afsA-3ihmA:
undetectable		 1afsA-3ihmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 LEU A 403
TYR A 401
ASN A 246
TYR A 180
 None
None
None
MYA  A1001 (-4.3A)
 1.34A 1afsA-3iu1A:
undetectable		 1afsA-3iu1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm7 PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE /
2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE

(Yersinia
enterocolitica) 		PF07071
(KDGP_aldolase) 		4 LEU A  40
THR A 229
ASN A  15
TYR A 218
 None
 1.09A 1afsA-3lm7A:
6.6		 1afsA-3lm7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0z PUTATIVE ALDOLASE

(Klebsiella
pneumoniae) 		PF07071
(KDGP_aldolase) 		4 LEU A  40
THR A 229
ASN A  15
TYR A 218
 None
None
None
SO4  A 301 (-4.7A)
 1.13A 1afsA-3m0zA:
7.0		 1afsA-3m0zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 LEU A 313
HIS A 256
THR A  13
TYR A 338
 None
 1.22A 1afsA-3mczA:
undetectable		 1afsA-3mczA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE

(Bacillus
anthracis) 		PF07071
(KDGP_aldolase) 		4 LEU A  41
THR A 231
ASN A  16
TYR A 220
 None
 1.05A 1afsA-3muxA:
5.6		 1afsA-3muxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE

(Aliivibrio
fischeri) 		PF07071
(KDGP_aldolase) 		4 LEU A  40
THR A 229
ASN A  15
TYR A 218
 None
 1.14A 1afsA-3nzrA:
5.3		 1afsA-3nzrA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		4 LEU A 475
TYR A 556
HIS A 438
THR A 532
 None
SO4  A 610 (-4.2A)
None
None
 1.27A 1afsA-3o0yA:
undetectable		 1afsA-3o0yA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		4 TYR A 346
THR A 395
ASN A 242
TYR A 214
 None
None
HP8  A 601 (-4.0A)
None
 1.40A 1afsA-3o82A:
undetectable		 1afsA-3o82A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		4 LEU A 230
TYR A 207
THR A  98
ASN A 144
 SAM  A 237 (-4.8A)
None
SO4  A 235 (-3.8A)
SAM  A 237 (-3.9A)
 1.36A 1afsA-3ooiA:
undetectable		 1afsA-3ooiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo0 E3 UBIQUITIN-PROTEIN
LIGASE TRIM21
IG GAMMA-2A CHAIN C
REGION, A ALLELE

(Mus musculus) 		PF00622
(SPRY)
PF07654
(C1-set)
PF13765
(PRY) 		4 TYR B  50
HIS A 436
THR B 101
ASN B  97
 None
 1.24A 1afsA-3zo0B:
undetectable		 1afsA-3zo0B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 414
TYR A 412
HIS A 154
THR A 186
 None
 1.35A 1afsA-3zx1A:
undetectable		 1afsA-3zx1A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 LEU A 149
THR A 215
ASN A 251
TYR A 489
 None
 1.30A 1afsA-4be9A:
undetectable		 1afsA-4be9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		4 LEU A  49
TYR A  41
THR A 257
ASN A 242
 None
C5P  A1000 (-3.5A)
None
None
 1.36A 1afsA-4berA:
undetectable		 1afsA-4berA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxm ERPC

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 LEU A  39
TYR A 146
ASN A 107
TYR A  68
 None
 1.14A 1afsA-4bxmA:
undetectable		 1afsA-4bxmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxm ERPC

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 TYR A 146
THR A  71
ASN A 107
TYR A  68
 None
 1.40A 1afsA-4bxmA:
undetectable		 1afsA-4bxmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 LEU A 403
TYR A 401
ASN A 246
TYR A 180
 None
None
NHW  A1000 (-4.8A)
NHW  A1000 ( 4.6A)
 1.38A 1afsA-4c2xA:
undetectable		 1afsA-4c2xA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7w SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 LEU A  92
HIS A 116
THR A 142
TYR A  67
 None
 1.27A 1afsA-4d7wA:
undetectable		 1afsA-4d7wA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4den ACTINOHIVIN

(actinomycete
K97-0003) 		PF00652
(Ricin_B_lectin) 		4 TYR A 107
THR A  88
TRP A 119
ASN A 129
 2M4  A 201 (-4.6A)
None
None
None
 1.33A 1afsA-4denA:
undetectable		 1afsA-4denA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 LEU A 339
TYR A 357
HIS A 336
THR A 249
 None
 0.92A 1afsA-4fgvA:
undetectable		 1afsA-4fgvA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk8 FERREDOXIN--NADP
REDUCTASE

(Burkholderia
thailandensis) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 181
TYR A 147
ASN A  49
TYR A  75
 None
 1.25A 1afsA-4fk8A:
undetectable		 1afsA-4fk8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		4 LEU A 328
THR A 388
ASN A 288
TYR A 279
 None
None
CL  A 503 ( 4.9A)
None
 1.13A 1afsA-4fxqA:
undetectable		 1afsA-4fxqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 LEU C 347
TYR C 365
HIS C 344
THR C 257
 None
 0.86A 1afsA-4hb4C:
undetectable		 1afsA-4hb4C:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00652
(Ricin_B_lectin) 		4 LEU C  80
THR C  53
TRP C  87
ASN C  97
 None
 1.39A 1afsA-4hr6C:
undetectable		 1afsA-4hr6C:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 LEU A 540
TYR A 544
HIS A 493
THR A 665
 None
 1.26A 1afsA-4igdA:
undetectable		 1afsA-4igdA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE

(Mycobacterium
tuberculosis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A 179
THR A 277
ASN A 263
TYR A 209
 None
 1.29A 1afsA-4ol9A:
undetectable		 1afsA-4ol9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8x URICASE

(Bacillus
fastidiosus) 		PF01014
(Uricase) 		4 LEU A 106
TYR A 103
HIS A 105
TYR A   7
 None
 1.27A 1afsA-4r8xA:
undetectable		 1afsA-4r8xA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7d ATP-DEPENDENT DNA
HELICASE Q1

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		4 LEU A 579
TYR A 554
HIS A 584
ASN A 488
 None
 1.00A 1afsA-4u7dA:
undetectable		 1afsA-4u7dA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		4 LEU A 305
THR A 179
TRP A 180
ASN A 170
 None
 1.10A 1afsA-4v1uA:
undetectable		 1afsA-4v1uA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 581
THR A 518
TRP A 558
ASN A 554
 None
 1.29A 1afsA-4wz9A:
undetectable		 1afsA-4wz9A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsh ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 LEU B  82
THR B 143
ASN B  55
TYR B  47
 None
None
NAI  B 301 (-4.3A)
NAI  B 301 ( 4.8A)
 1.10A 1afsA-4xshB:
undetectable		 1afsA-4xshB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 LEU A1287
TYR A1250
THR A1229
TYR A1207
 None
 1.19A 1afsA-4yknA:
undetectable		 1afsA-4yknA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A2535
THR A2450
ASN A2524
TYR A2526
 None
 1.26A 1afsA-4z37A:
undetectable		 1afsA-4z37A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 LEU A 558
TYR A 557
THR A 504
ASN A1331
 None
 0.92A 1afsA-5a22A:
undetectable		 1afsA-5a22A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		4 LEU A 153
THR A  47
ASN A  54
TYR A 221
 None
 1.22A 1afsA-5a2oA:
undetectable		 1afsA-5a2oA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12859
(ANAPC1)
PF12862
(ANAPC5) 		4 LEU O 590
TYR O 591
HIS O 561
ASN A 776
 None
 1.09A 1afsA-5a31O:
undetectable		 1afsA-5a31O:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL

(Escherichia
virus T4;
Homo sapiens) 		PF00959
(Phage_lysozyme) 		4 LEU A1156
THR A 151
ASN A 101
TYR A 161
 None
 1.34A 1afsA-5bz6A:
undetectable		 1afsA-5bz6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmw EPSIN-5

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		4 LEU A 180
TYR A 173
THR A  69
ASN A 118
 GOL  A 201 ( 4.2A)
None
None
None
 1.37A 1afsA-5cmwA:
undetectable		 1afsA-5cmwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hci GPN-LOOP GTPASE 1

(Saccharomyces
cerevisiae) 		PF03029
(ATP_bind_1) 		4 LEU A 232
TYR A 229
ASN A 153
TYR A 137
 None
 1.35A 1afsA-5hciA:
undetectable		 1afsA-5hciA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 LEU A1328
THR A1087
ASN A1256
TYR A1105
 None
 1.38A 1afsA-5i6hA:
undetectable		 1afsA-5i6hA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		4 LEU A 147
HIS A 266
THR A 167
TYR A 251
 None
 1.13A 1afsA-5ig2A:
undetectable		 1afsA-5ig2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 LEU A 161
TYR A 157
THR A 118
TRP A 119
 None
 1.39A 1afsA-5j3pA:
undetectable		 1afsA-5j3pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcd CHITIN
ELICITOR-BINDING
PROTEIN

(Oryza sativa) 		PF01476
(LysM) 		4 LEU A 175
TYR A 192
THR A  48
ASN A  74
 None
 1.30A 1afsA-5jcdA:
undetectable		 1afsA-5jcdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jce CHITIN
ELICITOR-BINDING
PROTEIN

(Oryza sativa) 		PF01476
(LysM) 		4 LEU A 175
TYR A 192
THR A  48
ASN A  74
 None
 1.36A 1afsA-5jceA:
undetectable		 1afsA-5jceA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 HIS A 253
THR A  26
ASN A  29
TYR A 317
 None
 1.32A 1afsA-5jozA:
undetectable		 1afsA-5jozA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 TYR A 105
HIS A  99
THR A 118
TYR A 114
 None
None
CA  A 805 (-4.3A)
None
 1.40A 1afsA-5k8dA:
undetectable		 1afsA-5k8dA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L13,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00572
(Ribosomal_L13) 		4 LEU L 217
TYR L 216
HIS L 220
THR L 144
 None
G  A   8 ( 4.9A)
None
None
 1.10A 1afsA-5mlcL:
undetectable		 1afsA-5mlcL:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 LEU A 216
TYR A 909
THR A 624
ASN A 792
 None
 1.18A 1afsA-5n0cA:
undetectable		 1afsA-5n0cA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 LEU B 329
TYR B 327
HIS B 220
THR B 230
 None
 1.25A 1afsA-5nd1B:
undetectable		 1afsA-5nd1B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 LEU B 580
HIS B 437
THR B 570
ASN B 490
 None
 0.90A 1afsA-5nd1B:
undetectable		 1afsA-5nd1B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 4 LEU A 249
TYR A 248
HIS A 253
THR A 184
 None
 1.14A 1afsA-5ndxA:
7.6		 1afsA-5ndxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 LEU A  47
TYR A  57
HIS A 270
ASN A 371
 None
 1.33A 1afsA-5svcA:
undetectable		 1afsA-5svcA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN SA
UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00318
(Ribosomal_S2)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 LEU C 149
TYR C 146
THR A 107
TYR A 109
 None
None
G  21102 ( 3.2A)
U  21101 ( 3.9A)
 1.32A 1afsA-5xyiC:
undetectable		 1afsA-5xyiC:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yyl -

(-) 		no annotation 4 TYR A 115
THR A  79
ASN A  64
TYR A  42
 None
 1.26A 1afsA-5yylA:
undetectable		 1afsA-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 4 LEU A1014
THR A1104
ASN A1089
TYR A1083
 None
 1.38A 1afsA-6bq1A:
undetectable		 1afsA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 LEU A2274
TYR A2276
ASN A2491
TYR A2422
 None
 1.40A 1afsA-6fb3A:
undetectable		 1afsA-6fb3A:
12.46