SIMILAR PATTERNS OF AMINO ACIDS FOR 1AEG_A_4APA296_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cij PROTEIN (HALOALKANE
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00561
(Abhydrolase_1) 		4 HIS A 289
GLY A 171
LEU A 263
ASP A 260
 None
 0.79A 1aegA-1cijA:
undetectable		 1aegA-1cijA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		4 HIS A 169
GLY A 172
LEU A 243
ASP A 246
 HEM  A 350 (-3.5A)
HEM  A 350 (-3.5A)
None
None
 0.45A 1aegA-1fhfA:
23.9		 1aegA-1fhfA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus) 		PF07745
(Glyco_hydro_53) 		4 HIS A 159
GLY A 155
LEU A 203
ASP A 206
 None
 0.64A 1aegA-1fobA:
undetectable		 1aegA-1fobA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 613
GLY A 617
LEU A 454
ASP A 451
 None
 0.85A 1aegA-1h17A:
undetectable		 1aegA-1h17A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 613
LYS A 614
GLY A 617
ASP A 451
 None
 0.83A 1aegA-1h17A:
undetectable		 1aegA-1h17A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4o PEROXIREDOXIN 5

(Homo sapiens) 		PF08534
(Redoxin) 		4 GLY A  46
THR A 147
GLY A  41
LEU A 116
 BEZ  A1162 (-3.1A)
BEZ  A1162 ( 4.0A)
None
None
 0.85A 1aegA-1h4oA:
undetectable		 1aegA-1h4oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		6 HIS A 259
GLY A 262
LYS A 263
MET A 367
LEU A 369
ASP A 372
 HEM  A 800 (-3.4A)
HEM  A 800 (-3.3A)
None
None
None
None
 0.44A 1aegA-1itkA:
32.5		 1aegA-1itkA:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iyn CHLOROPLASTIC
ASCORBATE PEROXIDASE

(Nicotiana
tabacum) 		PF00141
(peroxidase) 		4 HIS A 163
GLY A 166
LEU A 221
ASP A 224
 HEM  A 296 (-3.4A)
HEM  A 296 (-3.2A)
HEM  A 296 ( 4.9A)
None
 0.37A 1aegA-1iynA:
32.9		 1aegA-1iynA:
32.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2w SORBITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		4 HIS A 173
GLY A 128
GLY A 131
LEU A 170
 None
 0.85A 1aegA-1k2wA:
undetectable		 1aegA-1k2wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 GLY A 241
THR A 181
GLY A 101
ASP A 141
 None
CDM  A1284 (-3.6A)
ANP  A1285 (-2.9A)
CDM  A1284 (-2.9A)
 0.78A 1aegA-1oj4A:
undetectable		 1aegA-1oj4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 5 HIS A 185
GLY A  71
MET A 222
LEU A 226
ASP A 213
 None
 1.49A 1aegA-1onsA:
undetectable		 1aegA-1onsA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		4 GLY B 475
GLY B 524
LEU B 297
ASP B 245
 POP  B 999 (-3.1A)
POP  B 999 (-2.9A)
None
None
 0.85A 1aegA-1ox4B:
undetectable		 1aegA-1ox4B:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7l AMINOACYLASE-1

(Homo sapiens) 		PF01546
(Peptidase_M20) 		4 HIS A  80
GLY B 347
GLY A 151
ASP A  82
 ZN  A1002 ( 3.2A)
None
None
None
 0.85A 1aegA-1q7lA:
undetectable		 1aegA-1q7lA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgj PEROXIDASE N

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		4 HIS A 165
GLY A 168
LEU A 239
ASP A 242
 HEM  A1350 (-3.4A)
HEM  A1350 (-3.5A)
None
None
 0.44A 1aegA-1qgjA:
24.2		 1aegA-1qgjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo4 PEROXIDASE

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		4 HIS A 169
GLY A 172
LEU A 243
ASP A 246
 HEM  A 374 (-3.5A)
HEM  A 374 (-3.4A)
None
None
 0.45A 1aegA-1qo4A:
24.2		 1aegA-1qo4A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE

(Salmonella
enterica) 		PF00583
(Acetyltransf_1) 		4 HIS A 127
GLY A 131
MET A 112
LEU A  78
 None
 0.83A 1aegA-1s5kA:
undetectable		 1aegA-1s5kA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME

(Arachis
hypogaea) 		PF00141
(peroxidase) 		4 HIS A 169
GLY A 172
LEU A 236
ASP A 239
 HEM  A 300 ( 3.3A)
HEM  A 300 (-3.4A)
HEM  A 300 ( 4.9A)
None
 0.39A 1aegA-1schA:
25.0		 1aegA-1schA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2e 2-HYDROXY-6-KETONONA
-2,4-DIENEDIOIC ACID
HYDROLASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 GLY A 135
THR A 137
GLY A 243
LEU A 220
 None
 0.74A 1aegA-1u2eA:
undetectable		 1aegA-1u2eA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpq HYPOTHETICAL PROTEIN
TM1631

(Thermotoga
maritima) 		PF01904
(DUF72) 		4 GLY A  75
THR A  73
MET A  92
LEU A 132
 None
 0.87A 1aegA-1vpqA:
undetectable		 1aegA-1vpqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		4 GLY A 541
THR A 543
LEU A 109
ASP A 113
 None
 0.62A 1aegA-1w7cA:
undetectable		 1aegA-1w7cA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y80 PREDICTED COBALAMIN
BINDING PROTEIN

(Moorella
thermoacetica) 		PF02310
(B12-binding) 		4 HIS A 101
GLY A 178
LEU A 149
ASP A  99
 B1M  A 301 (-3.6A)
B1M  A 301 (-3.2A)
B1M  A 301 (-4.3A)
B1M  A 301 (-4.2A)
 0.85A 1aegA-1y80A:
undetectable		 1aegA-1y80A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydm HYPOTHETICAL PROTEIN
YQGN

(Bacillus
subtilis) 		PF01812
(5-FTHF_cyc-lig) 		4 GLY A 137
GLY A 134
LEU A 167
ASP A 170
 SO4  A 301 (-3.8A)
SO4  A 301 (-3.3A)
None
None
 0.85A 1aegA-1ydmA:
undetectable		 1aegA-1ydmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aky ADENYLATE KINASE

(Saccharomyces
cerevisiae) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 GLY A  11
THR A 184
GLY A  90
LEU A  62
 None
None
AP5  A 301 (-4.3A)
AP5  A 301 ( 4.1A)
 0.85A 1aegA-2akyA:
undetectable		 1aegA-2akyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b44 GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		4 HIS A 293
GLY A 240
GLY A 285
ASP A 214
 ZN  A 400 ( 3.1A)
None
PO4  A 500 (-3.6A)
ZN  A 400 ( 2.2A)
 0.77A 1aegA-2b44A:
undetectable		 1aegA-2b44A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 THR A 548
GLY A 553
LEU A 527
ASP A 524
 None
 0.83A 1aegA-2bxyA:
undetectable		 1aegA-2bxyA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		4 GLY A 297
GLY A  91
LEU A  70
ASP A  80
 None
 0.81A 1aegA-2canA:
undetectable		 1aegA-2canA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 GLY A  92
THR A 131
GLY A  86
LEU A 140
 None
 0.86A 1aegA-2iw1A:
undetectable		 1aegA-2iw1A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxh POLY(U)-BINDING-SPLI
CING FACTOR PUF60

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLY A 251
LYS A 250
GLY A 253
ASP A 222
 None
 0.82A 1aegA-2kxhA:
undetectable		 1aegA-2kxhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2luw METALLOPROTEASE

(Vibrio
vulnificus) 		PF04151
(PPC) 		4 GLY A  18
LYS A  17
GLY A  15
ASP A  45
 None
 0.71A 1aegA-2luwA:
undetectable		 1aegA-2luwA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg4 UNCHARACTERIZED
PROTEIN

(Aeropyrum
pernix) 		no annotation 4 GLY A  58
THR A   5
GLY A  78
LEU A  13
 None
 0.86A 1aegA-2pg4A:
undetectable		 1aegA-2pg4A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvk YJHT

(Escherichia
coli) 		PF01344
(Kelch_1) 		4 GLY A 126
THR A 124
GLY A 190
LEU A 205
 None
 0.74A 1aegA-2uvkA:
undetectable		 1aegA-2uvkA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xj6 ASCORBATE PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		4 HIS A 163
GLY A 166
LEU A 205
ASP A 208
 HEM  A1001 (-3.2A)
HEM  A1001 (-3.2A)
HEM  A1001 ( 4.9A)
None
 0.40A 1aegA-2xj6A:
34.5		 1aegA-2xj6A:
36.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		4 GLY A 316
THR A 267
GLY A 320
LEU A 135
 None
 0.72A 1aegA-2xxlA:
undetectable		 1aegA-2xxlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 GLY A 537
GLY A 540
LEU A 550
ASP A 554
 None
 0.70A 1aegA-2y6iA:
undetectable		 1aegA-2y6iA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		4 GLY A 138
THR A 287
GLY A 133
LEU A 168
 None
 0.74A 1aegA-2yrrA:
undetectable		 1aegA-2yrrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		4 GLY A 272
GLY A  55
LEU A  34
ASP A  44
 None
 0.83A 1aegA-2zukA:
undetectable		 1aegA-2zukA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		5 GLY B 198
LYS B 210
THR B 211
GLY B 208
LEU B  51
 None
 1.16A 1aegA-3adaB:
undetectable		 1aegA-3adaB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		4 GLY A 366
THR A 358
GLY A 373
ASP A 376
 None
 0.79A 1aegA-3d5eA:
undetectable		 1aegA-3d5eA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e2n CYTOCHROME C
PEROXIDASE

(Pisum sativum;
Saccharomyces
cerevisiae) 		PF00141
(peroxidase) 		7 HIS A 168
GLY A 171
LYS A 172
THR A 173
MET A 223
LEU A 225
ASP A 228
 HEM  A 296 (-3.2A)
HEM  A 296 (-3.2A)
None
HEM  A 296 (-4.3A)
None
HEM  A 296 (-4.8A)
None
 0.96A 1aegA-3e2nA:
47.6		 1aegA-3e2nA:
93.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		4 THR A  76
GLY A 308
LEU A 301
ASP A 299
 None
 0.72A 1aegA-3efvA:
undetectable		 1aegA-3efvA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffs INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		4 GLY A  67
GLY A  61
MET A  58
LEU A 278
 None
 0.86A 1aegA-3ffsA:
undetectable		 1aegA-3ffsA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fok UNCHARACTERIZED
PROTEIN CGL0159

(Corynebacterium
glutamicum) 		no annotation 5 GLY A 244
THR A 271
GLY A 273
LEU A  89
ASP A  50
 None
 1.15A 1aegA-3fokA:
undetectable		 1aegA-3fokA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		4 HIS A 292
GLY A 210
LEU A 264
ASP A 262
 SEP  A 165 ( 3.9A)
None
None
None
 0.66A 1aegA-3ga7A:
undetectable		 1aegA-3ga7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		4 HIS A 292
GLY A 215
GLY A 210
LEU A 264
 SEP  A 165 ( 3.9A)
None
None
None
 0.66A 1aegA-3ga7A:
undetectable		 1aegA-3ga7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  99
GLY A  97
MET A  69
LEU A  47
 None
 0.76A 1aegA-3gazA:
undetectable		 1aegA-3gazA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdl ROYAL PALM TREE
PEROXIDASE

(Roystonea regia) 		PF00141
(peroxidase) 		4 HIS A 169
GLY A 172
LEU A 245
ASP A 248
 HEM  A 305 (-3.4A)
HEM  A 305 ( 3.2A)
HEM  A 305 (-4.8A)
None
 0.39A 1aegA-3hdlA:
24.4		 1aegA-3hdlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		4 GLY A 249
THR A 247
LEU A 154
ASP A 121
 None
 0.86A 1aegA-3ipcA:
undetectable		 1aegA-3ipcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		4 HIS A 213
GLY A 310
GLY A 218
LEU A 209
 None
 0.85A 1aegA-3ivrA:
undetectable		 1aegA-3ivrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh9 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Pseudomonas
aeruginosa) 		PF08534
(Redoxin) 		4 GLY A  62
LYS A 145
GLY A 147
LEU A 142
 None
 0.80A 1aegA-3kh9A:
undetectable		 1aegA-3kh9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 HIS A 417
THR A 411
GLY A 402
ASP A 324
 None
 0.80A 1aegA-3q9tA:
undetectable		 1aegA-3q9tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		4 HIS A 180
GLY A 217
GLY A 153
MET A 156
 None
 0.87A 1aegA-3s6jA:
undetectable		 1aegA-3s6jA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		4 HIS A 196
GLY A 199
GLY A 203
ASP A 146
 None
None
None
ZN  A 472 (-3.1A)
 0.85A 1aegA-3tp9A:
undetectable		 1aegA-3tp9A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsc PUTATIVE
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 HIS A 191
GLY A 146
GLY A 149
LEU A 188
 None
 0.79A 1aegA-3tscA:
undetectable		 1aegA-3tscA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLY A  90
THR A  61
GLY A  58
ASP A  53
 None
None
NAG  A 547 ( 3.9A)
NAG  A 547 (-3.6A)
 0.80A 1aegA-3uggA:
undetectable		 1aegA-3uggA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		6 HIS A 314
GLY A 317
LYS A 318
THR A 319
LEU A 421
ASP A 424
 HEM  A1500 (-3.2A)
HEM  A1500 (-3.2A)
None
HEM  A1500 (-3.8A)
None
None
 0.38A 1aegA-3ut2A:
32.1		 1aegA-3ut2A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 HIS A 195
GLY A 150
GLY A 153
LEU A 192
 None
None
PG4  A 305 ( 4.2A)
None
 0.74A 1aegA-3uveA:
undetectable		 1aegA-3uveA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		4 HIS A 263
GLY A 266
LYS A 267
ASP A 375
 HEM  A 801 (-3.3A)
HEM  A 801 (-3.1A)
None
None
 0.57A 1aegA-3wxoA:
31.5		 1aegA-3wxoA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus) 		PF00141
(peroxidase) 		4 HIS A 171
GLY A 174
LEU A 245
ASP A 248
 HEM  A1307 (-3.4A)
HEM  A1307 (-3.3A)
HEM  A1307 ( 4.7A)
None
 0.41A 1aegA-4a5gA:
24.3		 1aegA-4a5gA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 GLY A 257
GLY A  54
LEU A  33
ASP A  43
 None
 0.85A 1aegA-4adeA:
undetectable		 1aegA-4adeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 GLY A 537
GLY A 540
LEU A 550
ASP A 554
 None
 0.81A 1aegA-4areA:
undetectable		 1aegA-4areA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 258
GLY A 256
LEU A 350
ASP A 220
 None
 0.71A 1aegA-4c2kA:
undetectable		 1aegA-4c2kA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		6 HIS A 270
GLY A 273
LYS A 274
THR A 275
LEU A 378
ASP A 381
 HEM  A1741 (-3.4A)
HEM  A1741 (-3.4A)
None
HEM  A1741 (-3.8A)
None
None
 0.34A 1aegA-4c51A:
32.0		 1aegA-4c51A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ch1 PROTEIN SUP-12,
ISOFORM B

(Caenorhabditis
elegans) 		PF00076
(RRM_1) 		4 GLY A  77
THR A  68
GLY A  79
ASP A  48
 None
 0.85A 1aegA-4ch1A:
undetectable		 1aegA-4ch1A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuo BANYAN PEROXIDASE

(Ficus
benghalensis) 		PF00141
(peroxidase) 		4 HIS A 169
GLY A 172
LEU A 243
ASP A 246
 HEM  A1307 (-3.3A)
HEM  A1307 (-3.3A)
HEM  A1307 ( 4.9A)
None
 0.43A 1aegA-4cuoA:
24.2		 1aegA-4cuoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		4 LYS A  73
THR A  74
GLY A 106
LEU A 122
 None
 0.77A 1aegA-4dppA:
undetectable		 1aegA-4dppA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eme M18 ASPARTYL
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF02127
(Peptidase_M18) 		4 GLY A 459
GLY A 528
MET A 436
LEU A 328
 None
 0.83A 1aegA-4emeA:
undetectable		 1aegA-4emeA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 HIS A 486
GLY A 521
GLY A 514
ASP A 459
 ZN  A1003 (-3.4A)
None
None
None
 0.80A 1aegA-4g9iA:
undetectable		 1aegA-4g9iA:
15.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		5 HIS A 192
GLY A 195
MET A 248
LEU A 250
ASP A 253
 HEM  A 401 (-3.4A)
HEM  A 401 (-3.2A)
None
None
None
 0.43A 1aegA-4gedA:
36.6		 1aegA-4gedA:
39.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		4 LYS A  35
THR A  36
GLY A  68
LEU A  84
 None
None
KPI  A 184 ( 3.5A)
None
 0.74A 1aegA-4hnnA:
undetectable		 1aegA-4hnnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 HIS A 102
GLY A 179
LEU A 150
ASP A 100
 COB  A 301 (-3.7A)
COB  A 301 (-3.2A)
COB  A 301 (-4.3A)
COB  A 301 (-3.5A)
 0.71A 1aegA-4jgiA:
undetectable		 1aegA-4jgiA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		5 GLY A 264
GLY A 173
MET A 246
LEU A 243
ASP A 242
 None
 1.34A 1aegA-4kqkA:
undetectable		 1aegA-4kqkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli) 		PF07859
(Abhydrolase_3) 		5 HIS A 292
GLY A 215
GLY A 210
LEU A 264
ASP A 262
 SEB  A 165 ( 4.1A)
None
None
None
None
 0.87A 1aegA-4kryA:
undetectable		 1aegA-4kryA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 GLY A 650
GLY A 448
LEU A 427
ASP A 437
 None
 0.81A 1aegA-4ppmA:
undetectable		 1aegA-4ppmA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		4 HIS A 343
GLY A 131
GLY A 345
LEU A 349
 ZN  A 502 ( 3.6A)
None
None
3PE  A 503 ( 4.6A)
 0.73A 1aegA-4qn9A:
undetectable		 1aegA-4qn9A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
HEMOPEXIN

(Haemophilus
influenzae;
Oryctolagus
cuniculus) 		PF00045
(Hemopexin)
PF05860
(Haemagg_act) 		4 GLY B 135
THR B 150
LEU A 552
ASP A 551
 None
 0.83A 1aegA-4rt6B:
undetectable		 1aegA-4rt6B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usc PEROXIDASE

(Trachycarpus
fortunei) 		PF00141
(peroxidase) 		4 HIS A 169
GLY A 172
LEU A 245
ASP A 248
 HEM  A1318 (-3.3A)
HEM  A1318 (-3.1A)
HEM  A1318 (-4.8A)
None
 0.42A 1aegA-4uscA:
24.4		 1aegA-4uscA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 GLY A 454
GLY A 587
LEU A 582
ASP A 583
 None
 0.61A 1aegA-4wd9A:
undetectable		 1aegA-4wd9A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER

(Escherichia
coli) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 GLY A 118
THR A 120
LEU A  83
ASP A  80
 None
None
None
480  A 303 (-2.4A)
 0.79A 1aegA-4y13A:
undetectable		 1aegA-4y13A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLY A 248
THR A 424
GLY A 251
LEU A 434
 MGD  A1003 (-3.8A)
MGD  A1003 ( 4.9A)
None
None
 0.81A 1aegA-5chcA:
undetectable		 1aegA-5chcA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 GLY A 134
THR A 136
GLY A 333
LEU A 128
 None
 0.83A 1aegA-5ereA:
undetectable		 1aegA-5ereA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff5 PAAA

(Pantoea
agglomerans) 		PF00899
(ThiF) 		4 HIS A 280
GLY A 282
LEU A 275
ASP A 277
 None
 0.78A 1aegA-5ff5A:
undetectable		 1aegA-5ff5A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 HIS C 149
THR C 162
GLY C 158
LEU C 135
 None
 0.77A 1aegA-5fmgC:
undetectable		 1aegA-5fmgC:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		4 GLY A 305
GLY A  97
LEU A  76
ASP A  86
 None
 0.84A 1aegA-5h7dA:
undetectable		 1aegA-5h7dA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxf 3C PROTEASE

(Enterovirus A) 		PF00548
(Peptidase_C3) 		4 GLY A 160
THR A 153
GLY A 150
LEU A  11
 None
 0.78A 1aegA-5hxfA:
undetectable		 1aegA-5hxfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		6 HIS A 279
GLY A 282
LYS A 283
THR A 284
LEU A 386
ASP A 389
 HEM  A 801 (-3.2A)
HEM  A 801 (-3.3A)
None
HEM  A 801 (-3.9A)
None
None
 0.38A 1aegA-5kqiA:
32.5		 1aegA-5kqiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		4 GLY A 272
GLY A  55
LEU A  34
ASP A  44
 None
 0.87A 1aegA-5m49A:
undetectable		 1aegA-5m49A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9m COBYRIC ACID
SYNTHASE

(Staphylococcus
aureus) 		no annotation 4 HIS A 179
GLY A 161
GLY A 177
LEU A 184
 None
 0.78A 1aegA-5n9mA:
undetectable		 1aegA-5n9mA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 GLY A 688
LYS A 689
THR A 336
GLY A 681
LEU A 433
 None
 1.11A 1aegA-5nqdA:
undetectable		 1aegA-5nqdA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 4 HIS A  64
GLY A  39
GLY A  68
ASP A  62
 None
 0.82A 1aegA-5o7gA:
undetectable		 1aegA-5o7gA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 GLY A  79
THR A 586
LEU A 389
ASP A 386
 None
 0.82A 1aegA-5t9gA:
undetectable		 1aegA-5t9gA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twt PEROXIDASE PVI9

(Panicum
virgatum) 		PF00141
(peroxidase) 		4 HIS A 167
GLY A 170
LEU A 233
ASP A 236
 HEM  A 301 (-3.3A)
HEM  A 301 (-3.0A)
HEM  A 301 (-4.2A)
None
 0.39A 1aegA-5twtA:
25.2		 1aegA-5twtA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		4 HIS A 143
GLY A 186
GLY A 141
ASP A 121
 EDO  A 509 ( 3.5A)
None
None
None
 0.78A 1aegA-5uamA:
undetectable		 1aegA-5uamA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 4 LYS D  33
THR D  34
GLY D  66
LEU D  82
 None
None
AKG  D 401 ( 3.8A)
None
 0.82A 1aegA-5ui3D:
undetectable		 1aegA-5ui3D:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v76 MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		no annotation 4 HIS A 144
GLY A 171
GLY A 147
LEU A 102
 None
 0.73A 1aegA-5v76A:
undetectable		 1aegA-5v76A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm2 ALCOHOL
DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  37
GLY A  64
MET A 115
LEU A 129
 None
 0.86A 1aegA-5vm2A:
undetectable		 1aegA-5vm2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 6 HIS A 279
GLY A 282
LYS A 283
THR A 284
LEU A 386
ASP A 389
 HEM  A 800 (-2.9A)
HEM  A 800 (-3.6A)
None
HEM  A 800 (-3.6A)
None
None
 0.59A 1aegA-5whsA:
31.9		 1aegA-5whsA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 HIS A 107
GLY A 438
GLY A  87
ASP A 105
 ZN  A 502 (-3.4A)
None
None
None
 0.83A 1aegA-5x4jA:
undetectable		 1aegA-5x4jA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t PROTEIN L3

(Spinacia
oleracea) 		PF00297
(Ribosomal_L3) 		5 HIS D 156
GLY D 161
THR D 124
MET D 165
LEU D 168
 C  A2803 ( 3.7A)
None
None
None
C  A2651 ( 4.7A)
 1.23A 1aegA-5x8tD:
undetectable		 1aegA-5x8tD:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeo CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 GLY A 179
GLY A 176
MET A 223
LEU A 208
 PLP  A 401 (-4.0A)
PLP  A 401 (-3.7A)
None
None
 0.67A 1aegA-5xeoA:
undetectable		 1aegA-5xeoA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 4 HIS A  55
GLY A  59
THR A 210
ASP A  85
 None
 0.73A 1aegA-5yo8A:
undetectable		 1aegA-5yo8A:
14.74