SIMILAR PATTERNS OF AMINO ACIDS FOR 1A8U_A_BEZA295

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 GLY A  27
SER A  94
PHE A 181
TRP A  28
HIS A 253
 PPI  A 278 ( 3.7A)
PPI  A 278 ( 2.7A)
None
None
PPI  A 278 ( 4.0A)
 1.25A 1a8uA-1a8sA:
42.1		 1a8uA-1a8sA:
45.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		8 GLY A  31
PHE A  32
LEU A 125
PHE A 163
TRP A 205
THR A 230
LEU A 231
HIS A 257
 None
None
None
None
CL  A 278 (-4.6A)
None
None
None
 0.62A 1a8uA-1brtA:
50.3		 1a8uA-1brtA:
98.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		8 GLY A  31
PHE A  32
SER A  98
PHE A 163
TRP A 205
THR A 230
LEU A 231
HIS A 257
 None
None
None
None
CL  A 278 (-4.6A)
None
None
None
 0.63A 1a8uA-1brtA:
50.3		 1a8uA-1brtA:
98.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		5 GLY A 134
SER A 135
LEU A 246
THR A 116
LEU A 117
 None
 1.26A 1a8uA-1c4xA:
25.9		 1a8uA-1c4xA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 GLY A 389
LEU A 362
PHE A3993
THR A 328
LEU A 323
 None
 1.35A 1a8uA-1cj0A:
2.0		 1a8uA-1cj0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctt CYTIDINE DEAMINASE

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2) 		5 GLY A 242
LEU A 215
PHE A  92
THR A 279
LEU A 280
 None
 1.27A 1a8uA-1cttA:
undetectable		 1a8uA-1cttA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		5 GLY A 399
SER A 400
LEU A 405
PHE A  80
LEU A  25
 None
 1.41A 1a8uA-1ehkA:
undetectable		 1a8uA-1ehkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus) 		PF04389
(Peptidase_M28) 		5 GLY A 101
PHE A 159
SER A 100
LEU A 261
THR A 220
 None
 1.49A 1a8uA-1f2pA:
3.1		 1a8uA-1f2pA:
24.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		7 GLY A  31
MET A  99
LEU A 125
PHE A 162
TRP A 204
LEU A 233
HIS A 259
 None
 0.29A 1a8uA-1hkhA:
48.4		 1a8uA-1hkhA:
68.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		6 SER A  98
MET A  99
LEU A 125
PHE A 162
TRP A 204
HIS A 259
 None
 0.70A 1a8uA-1hkhA:
48.4		 1a8uA-1hkhA:
68.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ism BONE MARROW STROMAL
CELL ANTIGEN 1

(Homo sapiens) 		PF02267
(Rib_hydrolayse) 		5 GLY A   6
SER A   8
LEU A  11
TRP A 111
LEU A 109
 None
 1.27A 1a8uA-1ismA:
undetectable		 1a8uA-1ismA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 GLY A  12
SER A  14
LEU A  18
THR A  38
LEU A  41
 None
 1.27A 1a8uA-1j6uA:
undetectable		 1a8uA-1j6uA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfr LIPASE

(Streptomyces
exfoliatus) 		PF03403
(PAF-AH_p_II) 		5 GLY A  62
PHE A  63
SER A 131
MET A 132
HIS A 209
 None
 0.75A 1a8uA-1jfrA:
16.0		 1a8uA-1jfrA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		5 GLY A  89
SER A 172
MET A 173
LEU A 232
HIS A 260
 None
None
PT  A 288 (-2.7A)
None
None
 0.90A 1a8uA-1jjfA:
14.3		 1a8uA-1jjfA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6z CYTOCHROME C4

(Pseudomonas
stutzeri) 		PF00034
(Cytochrom_C) 		5 GLY A 103
PHE A 107
LEU A 174
THR A 146
LEU A 150
 None
None
None
HEC  A 200 ( 4.2A)
HEC  A 200 (-4.8A)
 1.03A 1a8uA-1m6zA:
undetectable		 1a8uA-1m6zA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 GLY A 161
PHE A 162
LEU A 155
TRP A 159
LEU A 134
 None
 1.38A 1a8uA-1p1mA:
undetectable		 1a8uA-1p1mA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		5 GLY A 468
SER A 461
LEU A 450
LEU A 459
HIS A 471
 None
 1.29A 1a8uA-1sqjA:
undetectable		 1a8uA-1sqjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 GLY A  26
PHE A  27
SER A  96
PHE A 159
HIS A 247
 PGO  A 601 ( 3.7A)
PGO  A 609 (-4.9A)
PGO  A 601 (-2.5A)
None
PGO  A 601 ( 4.7A)
 0.84A 1a8uA-1womA:
32.1		 1a8uA-1womA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		5 GLY A 183
PHE A 167
PHE A 153
THR A 186
LEU A 230
 None
 1.23A 1a8uA-1zwxA:
undetectable		 1a8uA-1zwxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		5 GLY A  80
PHE A  78
SER A  81
LEU A  39
LEU A  83
 None
 1.39A 1a8uA-1zypA:
undetectable		 1a8uA-1zypA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 GLY A 227
PHE A 223
LEU A 258
PHE A 145
LEU A 240
 None
 1.36A 1a8uA-2cy8A:
undetectable		 1a8uA-2cy8A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d40 PUTATIVE GENTISATE
1,2-DIOXYGENASE

(Escherichia
coli) 		PF07883
(Cupin_2) 		5 GLY A 257
PHE A 325
MET A 256
PHE A 323
LEU A 138
 None
 1.36A 1a8uA-2d40A:
undetectable		 1a8uA-2d40A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 5 GLY A  25
PHE A  26
SER A 124
MET A 125
HIS A 355
 None
 0.65A 1a8uA-2hihA:
14.0		 1a8uA-2hihA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		5 GLY A 439
PHE A 443
LEU A 559
PHE A 456
LEU A 549
 None
 1.13A 1a8uA-2i7nA:
undetectable		 1a8uA-2i7nA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7p PANTOTHENATE KINASE
3

(Homo sapiens) 		PF03630
(Fumble) 		5 GLY A 214
PHE A 218
LEU A 334
PHE A 231
LEU A 324
 None
 1.07A 1a8uA-2i7pA:
undetectable		 1a8uA-2i7pA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		5 GLY A 197
LEU A  36
PHE A 226
THR A 253
LEU A 276
 None
 1.44A 1a8uA-2p4zA:
2.1		 1a8uA-2p4zA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		5 GLY A  44
SER A 120
MET A 121
LEU A 204
HIS A 231
 GOL  A1259 (-3.2A)
GOL  A1259 (-2.9A)
None
None
GOL  A1259 (-3.9A)
 0.80A 1a8uA-2uz0A:
14.7		 1a8uA-2uz0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 GLY A 443
LEU A 488
PHE A 471
THR A 475
LEU A 478
 None
 1.33A 1a8uA-2w1zA:
undetectable		 1a8uA-2w1zA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 GLY A 253
SER A 255
MET A 256
LEU A 259
LEU A 283
 None
IPA  A1408 (-4.2A)
IPA  A1408 (-3.1A)
None
None
 1.15A 1a8uA-2wgyA:
undetectable		 1a8uA-2wgyA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		5 GLY A  22
PHE A  23
SER A  89
MET A  90
HIS A 243
 None
 0.86A 1a8uA-2xmzA:
28.1		 1a8uA-2xmzA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		5 PHE A  48
LEU A  57
PHE A  37
THR A 299
LEU A 300
 None
 1.09A 1a8uA-2xn6A:
undetectable		 1a8uA-2xn6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF03717
(PBP_dimer) 		5 GLY A 218
PHE A 197
SER A 222
MET A 219
LEU A 223
 None
 1.45A 1a8uA-2z2mA:
undetectable		 1a8uA-2z2mA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl3 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Helicobacter
pylori) 		PF00574
(CLP_protease) 		5 GLY A 101
PHE A 103
LEU A  33
THR A  91
LEU A  63
 None
 1.47A 1a8uA-2zl3A:
undetectable		 1a8uA-2zl3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adl RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo sapiens) 		PF00035
(dsrm) 		5 PHE A 201
MET A 221
LEU A 164
LEU A 167
HIS A 226
 None
 1.45A 1a8uA-3adlA:
undetectable		 1a8uA-3adlA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqk POLY(A) POLYMERASE

(Escherichia
coli) 		PF01743
(PolyA_pol)
PF12626
(PolyA_pol_arg_C)
PF12627
(PolyA_pol_RNAbd) 		5 GLY A 413
LEU A 408
PHE A 386
TRP A 412
LEU A 393
 None
 1.17A 1a8uA-3aqkA:
undetectable		 1a8uA-3aqkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu7 GENTISATE
1,2-DIOXYGENASE

(Ruegeria
pomeroyi) 		PF07883
(Cupin_2) 		5 GLY A 275
PHE A 346
MET A 274
PHE A 344
LEU A 153
 None
 1.41A 1a8uA-3bu7A:
undetectable		 1a8uA-3bu7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhw D-METHIONINE
TRANSPORT SYSTEM
PERMEASE PROTEIN
METI

(Escherichia
coli) 		PF00528
(BPD_transp_1) 		5 GLY A  24
PHE A  21
SER A  23
LEU A 154
LEU A 157
 None
 1.38A 1a8uA-3dhwA:
undetectable		 1a8uA-3dhwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0x LIPASE-ESTERASE
RELATED PROTEIN

(Clostridium
acetobutylicum) 		PF12146
(Hydrolase_4) 		5 GLY A  21
LEU A 112
PHE A 118
THR A 199
HIS A 224
 OXE  A 243 (-3.8A)
None
None
None
OXE  A 243 (-4.1A)
 1.50A 1a8uA-3e0xA:
27.5		 1a8uA-3e0xA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER

([Haemophilus]
ducreyi) 		PF04310
(MukB)
PF13558
(SbcCD_C) 		5 GLY A1402
SER A1404
LEU A1290
THR A1446
LEU A1450
 None
 1.49A 1a8uA-3eujA:
undetectable		 1a8uA-3eujA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2e SIRV COAT PROTEIN

(Rudivirus) 		PF12193
(Sulf_coat_C) 		5 GLY A 102
MET A  99
LEU A  96
PHE A  79
THR A 122
 None
CIT  A 200 ( 4.7A)
None
None
None
 1.30A 1a8uA-3f2eA:
undetectable		 1a8uA-3f2eA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f67 PUTATIVE
DIENELACTONE
HYDROLASE

(Klebsiella
pneumoniae) 		PF01738
(DLH) 		5 GLY A 227
LEU A 232
PHE A 119
TRP A 228
THR A 117
 None
 1.21A 1a8uA-3f67A:
16.8		 1a8uA-3f67A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 GLY A 522
PHE A 520
LEU A 559
THR A 540
LEU A 568
 None
 0.95A 1a8uA-3fjoA:
2.9		 1a8uA-3fjoA:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fob BROMOPEROXIDASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		6 GLY A  32
SER A  99
MET A 100
PHE A 164
THR A 231
HIS A 258
 CL  A 401 ( 4.1A)
CL  A 401 (-2.9A)
CL  A 401 (-4.5A)
None
None
None
 0.54A 1a8uA-3fobA:
45.3		 1a8uA-3fobA:
48.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fob BROMOPEROXIDASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		6 GLY A  32
SER A  99
PHE A 164
TRP A  33
THR A 231
HIS A 258
 CL  A 401 ( 4.1A)
CL  A 401 (-2.9A)
None
None
None
None
 1.31A 1a8uA-3fobA:
45.3		 1a8uA-3fobA:
48.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 GLY A 616
MET A 619
LEU A 622
THR A 659
LEU A 658
 None
 1.38A 1a8uA-3g06A:
undetectable		 1a8uA-3g06A:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 GLY A  27
SER A  94
MET A  95
TRP A  28
HIS A 251
 EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
EEE  A 300 (-4.6A)
None
EEE  A 300 (-4.3A)
 1.29A 1a8uA-3heaA:
43.3		 1a8uA-3heaA:
39.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		5 GLY A  60
SER A 132
MET A 133
LEU A 158
HIS A 279
 F4P  A 314 ( 3.7A)
F4P  A 314 (-1.2A)
None
F4P  A 314 (-4.8A)
F4P  A 314 (-4.3A)
 0.84A 1a8uA-3jweA:
25.3		 1a8uA-3jweA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvd LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 PHE D 161
SER D 139
LEU D  81
THR D 130
LEU D 133
 None
 1.37A 1a8uA-3kvdD:
undetectable		 1a8uA-3kvdD:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw9 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 MET A 383
LEU A 395
PHE A 423
THR A 488
LEU A 489
 None
 1.45A 1a8uA-3lw9A:
undetectable		 1a8uA-3lw9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		5 PHE A  95
SER A  63
LEU A  59
THR A  31
LEU A  34
 None
 1.21A 1a8uA-3o82A:
2.5		 1a8uA-3o82A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ova CCA-ADDING ENZYME

(Archaeoglobus
fulgidus) 		PF01909
(NTP_transf_2)
PF09249
(tRNA_NucTransf2) 		5 GLY A 153
PHE A 154
LEU A   7
PHE A 238
THR A 188
 None
 1.43A 1a8uA-3ovaA:
undetectable		 1a8uA-3ovaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 GLY A 545
PHE A 543
LEU A 582
THR A 563
LEU A 591
 None
 0.95A 1a8uA-3qfsA:
undetectable		 1a8uA-3qfsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN

(Enterococcus
gallinarum) 		PF01636
(APH) 		5 GLY A 101
PHE A 202
MET A 105
LEU A 108
LEU A 206
 None
 1.47A 1a8uA-3tdwA:
undetectable		 1a8uA-3tdwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyd LC-EST1C

(uncultured
organism) 		PF00326
(Peptidase_S9) 		5 GLY A 327
SER A 399
MET A 400
THR A 449
HIS A 479
 None
 0.75A 1a8uA-3wydA:
16.0		 1a8uA-3wydA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 GLY A  25
SER A  20
LEU A  44
THR A  53
LEU A  54
 None
 1.21A 1a8uA-3zhyA:
4.2		 1a8uA-3zhyA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b29 DIMETHYLSULFONIOPROP
IONATE LYASE

(Roseovarius
nubinhibens) 		PF16867
(DMSP_lyase) 		5 GLY A 119
PHE A  94
LEU A  50
THR A 179
LEU A 178
 PO4  A1200 (-3.6A)
None
None
EDO  A1201 (-3.5A)
None
 1.24A 1a8uA-4b29A:
undetectable		 1a8uA-4b29A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cni INTERLEUKIN-6

(Homo sapiens) 		PF00489
(IL6) 		5 GLY C  90
LEU C 126
PHE C 170
THR C 119
LEU C 122
 None
 1.42A 1a8uA-4cniC:
undetectable		 1a8uA-4cniC:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0j PROBABLE HYDROLYTIC
ENZYME

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 GLY A  74
SER A 142
MET A 143
THR A 271
HIS A 313
 SO4  A 402 ( 3.4A)
SO4  A 402 ( 2.4A)
None
EDO  A 407 ( 4.0A)
SO4  A 402 ( 3.6A)
 0.87A 1a8uA-4f0jA:
28.9		 1a8uA-4f0jA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME

(unidentified) 		PF12146
(Hydrolase_4) 		5 GLY A  57
PHE A  58
SER A 126
MET A 127
HIS A 257
 SPD  A 301 (-3.5A)
None
SPD  A 301 ( 2.3A)
None
SPD  A 301 (-3.2A)
 0.84A 1a8uA-4fblA:
21.7		 1a8uA-4fblA:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		10 GLY A  31
PHE A  32
SER A  98
MET A  99
LEU A 125
PHE A 163
TRP A 205
THR A 230
LEU A 231
HIS A 257
 None
 0.51A 1a8uA-4iq4A:
50.7		 1a8uA-4iq4A:
98.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		5 GLY A 184
PHE A 186
SER A 227
PHE A 605
THR A 603
 None
 1.34A 1a8uA-4jc8A:
undetectable		 1a8uA-4jc8A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		5 GLY A 437
SER A 435
MET A 436
LEU A 389
LEU A 391
 None
 1.41A 1a8uA-4kvlA:
undetectable		 1a8uA-4kvlA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Bacillus sp.
H-257) 		PF12146
(Hydrolase_4) 		5 GLY A  28
PHE A  29
SER A  97
MET A  98
HIS A 226
 SO4  A 302 (-3.6A)
None
SO4  A 302 (-2.7A)
None
SO4  A 302 (-3.9A)
 0.68A 1a8uA-4lheA:
21.4		 1a8uA-4lheA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 GLY A 398
PHE A 397
LEU A 402
PHE A 318
TRP A 393
 None
 0.86A 1a8uA-4lq1A:
undetectable		 1a8uA-4lq1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 PHE A 646
LEU A 664
PHE A 117
TRP A 647
LEU A 661
 None
 1.42A 1a8uA-4m0mA:
9.5		 1a8uA-4m0mA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5) 		5 GLY A 506
SER A 505
LEU A 387
THR A 614
LEU A 500
 GLY  A 506 ( 0.0A)
SER  A 505 ( 0.0A)
LEU  A 387 ( 0.5A)
THR  A 614 ( 0.8A)
LEU  A 500 ( 0.6A)
 1.38A 1a8uA-4mtpA:
undetectable		 1a8uA-4mtpA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		5 GLY A  49
PHE A  50
SER A 116
MET A 117
HIS A 266
 None
 0.69A 1a8uA-4ns4A:
28.4		 1a8uA-4ns4A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens) 		PF08242
(Methyltransf_12)
PF08659
(KR) 		5 GLY A2035
PHE A2036
SER A2032
LEU A1460
LEU A1980
 None
 1.16A 1a8uA-4pivA:
4.3		 1a8uA-4pivA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qok MEL5 TCR CHAIN BETA

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY E  87
PHE E  88
LEU E  21
THR E  10
LEU E  11
 None
 1.44A 1a8uA-4qokE:
undetectable		 1a8uA-4qokE:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx1 ESTERASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		5 GLY A  50
SER A  10
PHE A 149
LEU A  11
HIS A 190
 None
 1.45A 1a8uA-4tx1A:
4.4		 1a8uA-4tx1A:
25.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uhh ESTERASE

(Thermogutta
terrifontis) 		PF00561
(Abhydrolase_1) 		5 GLY A  34
PHE A  35
SER A 101
MET A 102
HIS A 250
 None
None
CAD  A1275 (-3.6A)
None
None
 0.72A 1a8uA-4uhhA:
32.4		 1a8uA-4uhhA:
30.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x90 GROUP XV
PHOSPHOLIPASE A2

(Homo sapiens) 		PF02450
(LCAT) 		5 GLY A  12
SER A 165
MET A 166
THR A 329
HIS A 359
 None
MPD  A 409 (-3.5A)
None
None
None
 0.61A 1a8uA-4x90A:
13.3		 1a8uA-4x90A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgh CITRATE SYNTHASE

(Burkholderia
thailandensis) 		PF00285
(Citrate_synt) 		5 GLY A 144
PHE A 254
LEU A 176
THR A 394
LEU A 173
 None
 1.40A 1a8uA-4xghA:
undetectable		 1a8uA-4xghA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		5 GLY A 458
PHE A 368
SER A 461
LEU A 361
LEU A 294
 None
 1.35A 1a8uA-4xniA:
undetectable		 1a8uA-4xniA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Mycobacterium
tuberculosis) 		PF01180
(DHO_dh) 		5 GLY A  67
PHE A  68
LEU A 104
THR A 315
LEU A 113
 FMN  A 401 (-3.2A)
None
FMN  A 401 ( 4.3A)
FMN  A 401 (-3.6A)
FMN  A 401 ( 4.6A)
 1.46A 1a8uA-4xq6A:
undetectable		 1a8uA-4xq6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		5 GLY A  48
PHE A  49
SER A 123
MET A 124
HIS A 281
 None
 0.68A 1a8uA-4zwnA:
22.9		 1a8uA-4zwnA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		5 GLY A  48
SER A 123
MET A 124
LEU A 151
HIS A 281
 None
 0.93A 1a8uA-4zwnA:
22.9		 1a8uA-4zwnA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 5 GLY A  85
PHE A  86
SER A 182
MET A 183
HIS A 426
 None
 0.52A 1a8uA-5ah1A:
13.5		 1a8uA-5ah1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		5 GLY A  92
PHE A  95
LEU A 214
THR A 341
LEU A 337
 None
 1.15A 1a8uA-5b58A:
undetectable		 1a8uA-5b58A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		5 GLY A 415
SER A 417
LEU A 441
THR A 353
LEU A 352
 None
 1.25A 1a8uA-5b5rA:
undetectable		 1a8uA-5b5rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		5 GLY A 418
SER A 417
LEU A 441
THR A 353
LEU A 352
 None
 1.24A 1a8uA-5b5rA:
undetectable		 1a8uA-5b5rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bjx WLAL PROTEIN

(Campylobacter
jejuni) 		no annotation 5 GLY A 278
SER A 277
THR A 375
LEU A 378
HIS A 350
 NAD  A 702 (-3.2A)
None
None
None
None
 1.34A 1a8uA-5bjxA:
4.3		 1a8uA-5bjxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq5 INSERTION SEQUENCE
IS5376 PUTATIVE
ATP-BINDING PROTEIN

(Geobacillus
stearothermophilus) 		PF01695
(IstB_IS21) 		5 GLY A 169
SER A 198
MET A 168
LEU A 196
LEU A 104
 None
 1.07A 1a8uA-5bq5A:
undetectable		 1a8uA-5bq5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd8 TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Deinococcus
radiodurans) 		PF12802
(MarR_2) 		5 GLY A  66
SER A  65
LEU A 139
THR A  61
LEU A 143
 None
 1.48A 1a8uA-5dd8A:
undetectable		 1a8uA-5dd8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idt GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		5 GLY A 175
PHE A 136
PHE A 119
THR A  43
LEU A  44
 None
 1.30A 1a8uA-5idtA:
undetectable		 1a8uA-5idtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irp ALANINE RACEMASE 2

(Bacillus
subtilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 294
SER A 296
LEU A 299
THR A 361
LEU A 359
 None
 1.20A 1a8uA-5irpA:
undetectable		 1a8uA-5irpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		5 PHE A  71
SER A 175
MET A 176
LEU A 343
HIS A 373
 None
 0.56A 1a8uA-5jkjA:
23.1		 1a8uA-5jkjA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 GLY A 454
SER A 447
LEU A 436
LEU A 445
HIS A 457
 None
 1.25A 1a8uA-5jwzA:
undetectable		 1a8uA-5jwzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd CCZ1

(Chaetomium
thermophilum) 		PF08217
(DUF1712) 		5 GLY B  18
PHE B  19
LEU B 239
THR B  46
LEU B  47
 None
 1.47A 1a8uA-5lddB:
undetectable		 1a8uA-5lddB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 5 GLY A  37
PHE A  38
SER A 114
MET A 115
HIS A 284
 None
 0.77A 1a8uA-5o7gA:
23.7		 1a8uA-5o7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		6 GLY A  65
SER A 152
MET A 153
LEU A 178
LEU A 238
HIS A 265
 None
None
None
IPA  A 303 ( 4.5A)
None
None
 1.02A 1a8uA-5volA:
15.0		 1a8uA-5volA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w35 DNA PRIMASE

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A 158
PHE A 157
LEU A 144
PHE A 249
LEU A 204
 None
 1.39A 1a8uA-5w35A:
undetectable		 1a8uA-5w35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 5 GLY A 400
SER A 399
LEU A 394
LEU A 444
HIS A 465
 U  B   5 ( 3.2A)
U  B   5 ( 4.3A)
None
None
None
 1.27A 1a8uA-5wzkA:
undetectable		 1a8uA-5wzkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Geobacillus sp.
12AMOR1) 		no annotation 5 GLY A  28
PHE A  29
SER A  97
MET A  98
HIS A 226
 None
 0.73A 1a8uA-5xksA:
21.3		 1a8uA-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 5 GLY A 191
SER A 154
MET A 190
LEU A 238
LEU A 151
 MLY  A 194 ( 4.6A)
None
MLY  A 240 ( 3.5A)
None
None
 1.40A 1a8uA-5z5cA:
undetectable		 1a8uA-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk6 HENDRA VIRUS MATRIX
PROTEIN

(Hendra
henipavirus) 		no annotation 5 GLY A 130
PHE A 129
SER A 131
LEU A 145
LEU A 113
 None
 1.39A 1a8uA-6bk6A:
undetectable		 1a8uA-6bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 5 SER A 747
LEU A 750
TRP A 777
LEU A 785
HIS A 428
 None
 1.31A 1a8uA-6c6lA:
undetectable		 1a8uA-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-) 		no annotation 5 PHE A  38
LEU A  47
PHE A  23
LEU A  10
HIS A 228
 None
 1.36A 1a8uA-6c7vA:
undetectable		 1a8uA-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 5 GLY A 253
SER A 251
LEU A 275
THR A 379
LEU A 248
 None
 1.50A 1a8uA-6co0A:
undetectable		 1a8uA-6co0A:
undetectable