SIMILAR PATTERNS OF AMINO ACIDS FOR 1A7Y_B_DVAB8_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cj2 | PROTEIN(P-HYDROXYBENZOATEHYDROXYLASE) (Pseudomonasfluorescens) |
PF01494(FAD_binding_3) | 3 | THR A 217THR A 192PRO A 194 | None | 0.73A | 1a7yB-1cj2A:undetectable | 1a7yB-1cj2A:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpt | CYTOCHROME P450-TERP (Pseudomonas sp.) |
PF00067(p450) | 3 | THR A 111THR A 109PRO A 107 | None | 0.72A | 1a7yB-1cptA:undetectable | 1a7yB-1cptA:5.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e0b | SWI6 PROTEIN (Schizosaccharomycespombe) |
PF01393(Chromo_shadow) | 3 | THR A 304THR A 306PRO A 302 | None | 0.87A | 1a7yB-1e0bA:undetectable | 1a7yB-1e0bA:5.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3d | [NIFE] HYDROGENASELARGE SUBUNIT (Desulfovibriodesulfuricans) |
PF00374(NiFeSe_Hases) | 3 | THR B 492THR B 493PRO B 491 | FNE B 543 (-3.8A)NoneFNE B 543 (-3.7A) | 0.85A | 1a7yB-1e3dB:undetectable | 1a7yB-1e3dB:4.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gq7 | PROCLAVAMINATEAMIDINO HYDROLASE (Streptomycesclavuligerus) |
PF00491(Arginase) | 3 | THR A 149THR A 162PRO A 151 | None | 0.88A | 1a7yB-1gq7A:undetectable | 1a7yB-1gq7A:6.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz4 | NAD-DEPENDENT MALICENZYME (Homo sapiens) |
PF00390(malic)PF03949(Malic_M) | 3 | THR A 113THR A 115PRO A 109 | None | 0.83A | 1a7yB-1gz4A:undetectable | 1a7yB-1gz4A:2.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3p | ANTIBODY FABFRAGMENT (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | THR H 62THR H 64PRO H 60 | None | 0.74A | 1a7yB-1h3pH:undetectable | 1a7yB-1h3pH:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7w | DIHYDROPYRIMIDINEDEHYDROGENASE (Sus scrofa) |
PF01180(DHO_dh)PF07992(Pyr_redox_2)PF14691(Fer4_20)PF14697(Fer4_21) | 3 | THR A 554THR A 555PRO A 553 | None | 0.83A | 1a7yB-1h7wA:undetectable | 1a7yB-1h7wA:1.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1he3 | BILIVERDIN IX BETAREDUCTASE (Homo sapiens) |
PF13460(NAD_binding_10) | 3 | THR A 199THR A 166PRO A 201 | None | 0.83A | 1a7yB-1he3A:undetectable | 1a7yB-1he3A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3u | ASPARTASE (Bacillus sp.YM55-1) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | THR A 147THR A 149PRO A 146 | None | 0.87A | 1a7yB-1j3uA:undetectable | 1a7yB-1j3uA:2.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 3 | THR A 99THR A 97PRO A 95 | None | 0.81A | 1a7yB-1jioA:undetectable | 1a7yB-1jioA:7.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qaf | PROTEIN (COPPERAMINE OXIDASE) (Escherichiacoli) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3)PF07833(Cu_amine_oxidN1) | 3 | THR A 688THR A 687PRO A 614 | None | 0.81A | 1a7yB-1qafA:undetectable | 1a7yB-1qafA:2.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qqh | PAPILLOMAVIRUSTRANSCRIPTION FACTORE2 (Alphapapillomavirus7) |
PF00508(PPV_E2_N) | 3 | THR A 107THR A 104PRO A 106 | None | 0.84A | 1a7yB-1qqhA:undetectable | 1a7yB-1qqhA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qyi | HYPOTHETICAL PROTEIN (Staphylococcusaureus) |
PF13242(Hydrolase_like) | 3 | THR A 243THR A 245PRO A 241 | None | 0.77A | 1a7yB-1qyiA:undetectable | 1a7yB-1qyiA:2.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tue | REGULATORY PROTEINE2 (Alphapapillomavirus7) |
PF00508(PPV_E2_N) | 3 | THR B 111THR B 108PRO B 110 | None | 0.87A | 1a7yB-1tueB:undetectable | 1a7yB-1tueB:5.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ujt | KIAA1568 PROTEIN (Homo sapiens) |
PF00041(fn3) | 3 | THR A 112THR A 111PRO A 29 | None | 0.83A | 1a7yB-1ujtA:undetectable | 1a7yB-1ujtA:9.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 3 | THR A1035THR A1032PRO A1034 | None | 0.87A | 1a7yB-1ux6A:undetectable | 1a7yB-1ux6A:4.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1za0 | POSSIBLEACYL-[ACYL-CARRIERPROTEIN] DESATURASEDESA2 (ACYL-[ACP]DESATURASE)(STEAROYL-ACPDESATURASE) (Mycobacteriumtuberculosis) |
PF03405(FA_desaturase_2) | 3 | THR A 64THR A 66PRO A 62 | None | 0.87A | 1a7yB-1za0A:undetectable | 1a7yB-1za0A:3.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrt | CYTOCHROME B (Rhodobactercapsulatus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 3 | THR C 241THR C 37PRO C 36 | None | 0.85A | 1a7yB-1zrtC:undetectable | 1a7yB-1zrtC:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d07 | G/TMISMATCH-SPECIFICTHYMINE DNAGLYCOSYLASE (Homo sapiens) |
PF03167(UDG) | 3 | THR A 121THR A 196PRO A 198 | None | 0.85A | 1a7yB-2d07A:undetectable | 1a7yB-2d07A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dzj | SYNAPTICGLYCOPROTEIN SC2 (Homo sapiens) |
no annotation | 3 | THR A 46THR A 44PRO A 48 | None | 0.82A | 1a7yB-2dzjA:undetectable | 1a7yB-2dzjA:8.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 3 | THR A 187THR A 185PRO A 154 | NonePLP A 400 (-3.6A)None | 0.88A | 1a7yB-2isqA:undetectable | 1a7yB-2isqA:4.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nnu | REGULATORY PROTEINE2 (Alphapapillomavirus9) |
PF00508(PPV_E2_N) | 3 | THR A 107THR A 104PRO A 106 | None | 0.72A | 1a7yB-2nnuA:undetectable | 1a7yB-2nnuA:5.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pa4 | UTP-GLUCOSE-1-PHOSPHATEURIDYLYLTRANSFERASE (Corynebacteriumglutamicum) |
PF00483(NTP_transferase) | 3 | THR A 32THR A 30PRO A 34 | None | 0.79A | 1a7yB-2pa4A:undetectable | 1a7yB-2pa4A:8.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pff | FATTY ACID SYNTHASESUBUNIT BETA (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF16073(SAT) | 3 | THR B 55THR B 56PRO B 54 | None | 0.80A | 1a7yB-2pffB:undetectable | 1a7yB-2pffB:1.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rfq | 3-HSA HYDROXYLASE,OXYGENASE (Rhodococcusjostii) |
PF02771(Acyl-CoA_dh_N)PF08028(Acyl-CoA_dh_2) | 3 | THR A 236THR A 237PRO A 235 | None | 0.87A | 1a7yB-2rfqA:undetectable | 1a7yB-2rfqA:3.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rs5 | HUMAN RHINOVIRUS 14COAT PROTEIN(SUBUNIT VP2) (Rhinovirus B) |
PF00073(Rhv) | 3 | THR 2 147THR 2 145PRO 2 149 | None | 0.81A | 1a7yB-2rs52:undetectable | 1a7yB-2rs52:7.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7z | HEAT SHOCK COGNATE71 KDA PROTEIN (Rattusnorvegicus) |
PF00012(HSP70) | 3 | THR A 64THR A 66PRO A 63 | None | 0.85A | 1a7yB-2v7zA:undetectable | 1a7yB-2v7zA:3.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9q | ROUNDABOUT HOMOLOG 1 (Homo sapiens) |
PF07679(I-set)PF13927(Ig_3) | 3 | THR A 228THR A 230PRO A 186 | None | 0.76A | 1a7yB-2v9qA:undetectable | 1a7yB-2v9qA:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5l | TYLACTONE SYNTHASESTARTER MODULE ANDMODULES 1 & 2 (Streptomycesfradiae) |
PF08659(KR) | 3 | THR A 36THR A 37PRO A 35 | None | 0.79A | 1a7yB-2z5lA:undetectable | 1a7yB-2z5lA:6.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5x | AMINE OXIDASE[FLAVIN-CONTAINING]A (Homo sapiens) |
PF01593(Amino_oxidase) | 3 | THR A 276THR A 278PRO A 274 | NoneNoneFAD A 600 ( 4.9A) | 0.77A | 1a7yB-2z5xA:undetectable | 1a7yB-2z5xA:1.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zm2 | 6-AMINOHEXANOATE-DIMER HYDROLASE (Flavobacteriumsp.) |
PF00144(Beta-lactamase) | 3 | THR A 320THR A 318PRO A 322 | None | 0.86A | 1a7yB-2zm2A:undetectable | 1a7yB-2zm2A:6.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 3 | THR A 115THR A 113PRO A 117 | None | 0.77A | 1a7yB-3ai7A:undetectable | 1a7yB-3ai7A:1.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE LARGESUBUNIT (Hydrogenovibriomarinus) |
PF00374(NiFeSe_Hases) | 3 | THR A 546THR A 547PRO A 545 | CYN A 605 (-3.7A)NoneCYN A 605 ( 3.6A) | 0.83A | 1a7yB-3ayxA:undetectable | 1a7yB-3ayxA:1.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csk | PROBABLEDIPEPTIDYL-PEPTIDASE3 (Saccharomycescerevisiae) |
PF03571(Peptidase_M49) | 3 | THR A 238THR A 236PRO A 240 | None | 0.73A | 1a7yB-3cskA:undetectable | 1a7yB-3cskA:1.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6j | PUTATIVE HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bacteroidesfragilis) |
PF13419(HAD_2) | 3 | THR A 94THR A 96PRO A 93 | None | 0.87A | 1a7yB-3d6jA:undetectable | 1a7yB-3d6jA:4.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg6 | ADSEVERIN (Homo sapiens) |
PF00626(Gelsolin) | 3 | THR A 702THR A 704PRO A 700 | None | 0.85A | 1a7yB-3fg6A:undetectable | 1a7yB-3fg6A:3.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1q | ETHANOLAMINEUTILIZATION PROTEINEUTJ (Carboxydothermushydrogenoformans) |
PF14450(FtsA) | 3 | THR A 147THR A 166PRO A 165 | None | 0.75A | 1a7yB-3h1qA:undetectable | 1a7yB-3h1qA:4.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hd8 | XYLANASE INHIBITOR (Triticumaestivum) |
PF14541(TAXi_C)PF14543(TAXi_N) | 3 | THR A 109THR A 108PRO A 4 | None | 0.85A | 1a7yB-3hd8A:undetectable | 1a7yB-3hd8A:3.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikm | DNA POLYMERASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00476(DNA_pol_A) | 3 | THR A 636THR A 638PRO A 635 | None | 0.75A | 1a7yB-3ikmA:undetectable | 1a7yB-3ikmA:0.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3juj | UDP-GLUCOSEPYROPHOSPHORYLASE(GALU) (Helicobacterpylori) |
PF00483(NTP_transferase) | 3 | THR A 22THR A 20PRO A 24 | None | 0.87A | 1a7yB-3jujA:undetectable | 1a7yB-3jujA:3.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kol | GLYOXALASE/BLEOMYCINRESISTANCEPROTEIN/DIOXYGENASE (Nostocpunctiforme) |
PF00903(Glyoxalase) | 3 | THR A 54THR A 56PRO A 52 | None | 0.86A | 1a7yB-3kolA:undetectable | 1a7yB-3kolA:8.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgg | METHYLTRANSFERASE (Methanosarcinamazei) |
PF13847(Methyltransf_31) | 3 | THR A 248THR A 254PRO A 150 | None | 0.84A | 1a7yB-3mggA:undetectable | 1a7yB-3mggA:7.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nz4 | PHENYLALANINEAMMONIA-LYASE (Taxuscanadensis) |
PF00221(Lyase_aromatic) | 3 | THR A 127THR A 129PRO A 125 | None | 0.70A | 1a7yB-3nz4A:undetectable | 1a7yB-3nz4A:1.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oc9 | UDP-N-ACETYLGLUCOSAMINEPYROPHOSPHORYLASE (Entamoebahistolytica) |
PF01704(UDPGP) | 3 | THR A 12THR A 10PRO A 14 | None | 0.83A | 1a7yB-3oc9A:undetectable | 1a7yB-3oc9A:2.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oks | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 3 | THR A 69THR A 70PRO A 425 | None | 0.81A | 1a7yB-3oksA:undetectable | 1a7yB-3oksA:2.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p40 | NEUROFASCIN (Homo sapiens) |
PF13927(Ig_3) | 3 | THR A 410THR A 367PRO A 366 | None | 0.81A | 1a7yB-3p40A:undetectable | 1a7yB-3p40A:2.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1y | LIN2199 PROTEIN (Listeriainnocua) |
PF00294(PfkB) | 3 | THR A 268THR A 270PRO A 266 | None | 0.70A | 1a7yB-3q1yA:undetectable | 1a7yB-3q1yA:5.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q8n | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 3 | THR A 76THR A 77PRO A 426 | None | 0.83A | 1a7yB-3q8nA:undetectable | 1a7yB-3q8nA:7.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4t | 4-AMINOBUTYRATEAMINOTRANSFERASEGABT (Mycobacteriummarinum) |
PF00202(Aminotran_3) | 3 | THR A 68THR A 69PRO A 424 | None | 0.80A | 1a7yB-3r4tA:undetectable | 1a7yB-3r4tA:2.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgw | MEMBRANE-BOUNDHYDROGENASE (NIFE)LARGE SUBUNIT HOXG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 3 | THR L 553THR L 554PRO L 552 | NFU L1004 (-3.8A)NoneNFU L1004 (-3.6A) | 0.84A | 1a7yB-3rgwL:undetectable | 1a7yB-3rgwL:1.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sc2 | SERINECARBOXYPEPTIDASE II(CPDW-II) (Triticumaestivum) |
PF00450(Peptidase_S10) | 3 | THR B 344THR B 346PRO B 342 | None | 0.66A | 1a7yB-3sc2B:undetectable | 1a7yB-3sc2B:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usc | HYDROGENASE-1 LARGECHAIN (Escherichiacoli) |
PF00374(NiFeSe_Hases) | 3 | THR L 532THR L 533PRO L 531 | FCO L 601 (-3.7A)NoneFCO L 601 (-3.5A) | 0.81A | 1a7yB-3uscL:undetectable | 1a7yB-3uscL:2.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zsu | TLL2057 PROTEIN (Thermosynechococcuselongatus) |
no annotation | 3 | THR A 103THR A 105PRO A 102 | None | 0.84A | 1a7yB-3zsuA:undetectable | 1a7yB-3zsuA:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4av6 | K(+)-STIMULATEDPYROPHOSPHATE-ENERGIZED SODIUM PUMP (Thermotogamaritima) |
PF03030(H_PPase) | 3 | THR A 421THR A 423PRO A 420 | None | 0.81A | 1a7yB-4av6A:undetectable | 1a7yB-4av6A:2.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btp | P1 (Pseudomonasphage phi8) |
no annotation | 3 | THR A 295THR A 297PRO A 299 | None | 0.71A | 1a7yB-4btpA:undetectable | 1a7yB-4btpA:3.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4byf | UNCONVENTIONALMYOSIN-IC (Homo sapiens) |
PF00063(Myosin_head)PF00612(IQ) | 3 | THR A 650THR A 647PRO A 649 | None | 0.87A | 1a7yB-4byfA:undetectable | 1a7yB-4byfA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases) | 3 | THR A 535THR A 536PRO A 534 | NFU A1004 (-3.7A)NoneNFU A1004 (-3.8A) | 0.84A | 1a7yB-4c3oA:undetectable | 1a7yB-4c3oA:2.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dza | LYSINE RACEMASE (Proteusmirabilis) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 3 | THR A 250THR A 248PRO A 252 | None | 0.78A | 1a7yB-4dzaA:undetectable | 1a7yB-4dzaA:8.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eog | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF09455(Cas_DxTHG) | 3 | THR A 174THR A 176PRO A 173 | None | 0.80A | 1a7yB-4eogA:undetectable | 1a7yB-4eogA:5.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1h | TYROSYL-DNAPHOSPHODIESTERASE 2 (Danio rerio) |
PF03372(Exo_endo_phos) | 3 | THR A 210THR A 211PRO A 209 | None | 0.80A | 1a7yB-4f1hA:undetectable | 1a7yB-4f1hA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fd0 | LEUCINE RICHHYPOTHETICAL PROTEIN (Bacteroidescaccae) |
PF07523(Big_3)PF13306(LRR_5) | 3 | THR A 193THR A 217PRO A 192 | None | 0.80A | 1a7yB-4fd0A:undetectable | 1a7yB-4fd0A:9.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ffc | 4-AMINOBUTYRATEAMINOTRANSFERASE(GABT) (Mycobacteroidesabscessus) |
PF00202(Aminotran_3) | 3 | THR A 72THR A 73PRO A 423 | None | 0.79A | 1a7yB-4ffcA:undetectable | 1a7yB-4ffcA:3.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h16 | SHORT CHAIN ALCOHOLDEHYDROGENASE-RELATED DEHYDROGENASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 3 | THR A 149THR A 148PRO A 145 | NoneP6G A 305 ( 4.5A)None | 0.80A | 1a7yB-4h16A:undetectable | 1a7yB-4h16A:3.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k24 | ANTI-UPAR ANTIBODY,HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | THR H 116THR H 117PRO H 147 | None | 0.84A | 1a7yB-4k24H:undetectable | 1a7yB-4k24H:7.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmp | ALANINEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 3 | THR A 310THR A 308PRO A 306 | None | 0.75A | 1a7yB-4lmpA:undetectable | 1a7yB-4lmpA:4.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n8g | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Chromohalobactersalexigens) |
PF03480(DctP) | 3 | THR A 200THR A 202PRO A 198 | None | 0.78A | 1a7yB-4n8gA:undetectable | 1a7yB-4n8gA:7.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovj | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Alicyclobacillusacidocaldarius) |
PF13416(SBP_bac_8) | 3 | THR A 257THR A 259PRO A 255 | None | 0.80A | 1a7yB-4ovjA:undetectable | 1a7yB-4ovjA:4.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmh | PECTINESTERASE (Sitophilusoryzae) |
PF01095(Pectinesterase) | 3 | THR A 143THR A 111PRO A 113 | None | 0.79A | 1a7yB-4pmhA:undetectable | 1a7yB-4pmhA:3.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r04 | TOXIN A (Clostridioidesdifficile) |
PF11713(Peptidase_C80)PF12918(TcdB_N)PF12919(TcdA_TcdB)PF12920(TcdA_TcdB_pore) | 3 | THR A 728THR A 726PRO A 730 | None | 0.87A | 1a7yB-4r04A:undetectable | 1a7yB-4r04A:0.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ry1 | PERIPLASMIC SOLUTEBINDING PROTEIN (Pectobacteriumatrosepticum) |
PF13416(SBP_bac_8) | 3 | THR A 165THR A 301PRO A 303 | None | 0.88A | 1a7yB-4ry1A:undetectable | 1a7yB-4ry1A:3.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3j | CORTICAL-LYTICENZYME (Bacillus cereus) |
PF00704(Glyco_hydro_18)PF01476(LysM) | 3 | THR A 162THR A 166PRO A 168 | None | 0.82A | 1a7yB-4s3jA:undetectable | 1a7yB-4s3jA:2.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tps | CHROMOSOMALREPLICATIONINITIATOR PROTEINDNAA (Bacillussubtilis) |
PF11638(DnaA_N) | 3 | THR B 31THR B 44PRO B 46 | None | 0.84A | 1a7yB-4tpsB:undetectable | 1a7yB-4tpsB:10.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uob | ENDONUCLEASE III-3 (Deinococcusradiodurans) |
PF00730(HhH-GPD) | 3 | THR A 152THR A 150PRO A 154 | None | 0.79A | 1a7yB-4uobA:undetectable | 1a7yB-4uobA:5.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uz1 | NOTUM (Homo sapiens) |
PF03283(PAE) | 3 | THR A 284THR A 282PRO A 287 | None | 0.85A | 1a7yB-4uz1A:undetectable | 1a7yB-4uz1A:2.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xnz | LIGHT CHAIN OFANTIBODY VRC06B (Homo sapiens) |
no annotation | 3 | THR L 10THR L 97PRO L 8 | None | 0.87A | 1a7yB-4xnzL:undetectable | 1a7yB-4xnzL:8.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvh | CARBOHYDRATEESTERASE FAMILY 2(CE2) (Chaetomium) |
PF13472(Lipase_GDSL_2) | 3 | THR A 288THR A 285PRO A 287 | None | 0.78A | 1a7yB-4xvhA:undetectable | 1a7yB-4xvhA:3.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yk2 | BARTONELLA EFFECTORPROTEIN (BEP)SUBSTRATE OF VIRBT4SS (Bartonellaclarridgeiae) |
no annotation | 3 | THR A 131THR A 129PRO A 134 | None | 0.81A | 1a7yB-4yk2A:undetectable | 1a7yB-4yk2A:4.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ac9 | VP1 (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | THR 1 68THR 1 70PRO 1 188 | None | 0.84A | 1a7yB-5ac91:undetectable | 1a7yB-5ac91:4.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bw8 | UBIQUITIN-LIKEPROTEIN MDY2 (Saccharomycescerevisiae) |
PF16843(Get5_bdg) | 3 | THR D 21THR D 23PRO D 25 | None | 0.75A | 1a7yB-5bw8D:undetectable | 1a7yB-5bw8D:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dis | MALTOSE-BINDINGPERIPLASMICPROTEIN,NUCLEAR PORECOMPLEX PROTEINNUP214 (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8) | 3 | THR D1944THR D1946PRO D1943 | None | 0.87A | 1a7yB-5disD:undetectable | 1a7yB-5disD:2.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dyn | PUTATIVE PEPTIDASE (Bacteroidesfragilis) |
PF03415(Peptidase_C11) | 3 | THR B 388THR B 282PRO B 278 | None | 0.82A | 1a7yB-5dynB:undetectable | 1a7yB-5dynB:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eod | COAGULATION FACTORXI (Homo sapiens) |
PF00024(PAN_1)PF00089(Trypsin) | 3 | THR A 393THR A 390PRO A 392 | None | 0.80A | 1a7yB-5eodA:undetectable | 1a7yB-5eodA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5has | SEC7 (Thielaviaterrestris) |
PF12783(Sec7_N)PF16213(DCB) | 3 | THR A 66THR A 64PRO A 62 | None | 0.73A | 1a7yB-5hasA:undetectable | 1a7yB-5hasA:2.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hs8 | HTH-TYPETRANSCRIPTIONALREGULATOR YODB (Bacillussubtilis) |
PF01638(HxlR) | 3 | THR A 41THR A 39PRO A 43 | None | 0.62A | 1a7yB-5hs8A:undetectable | 1a7yB-5hs8A:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ify | GLUCOSE-1-PHOSPHATETHYMIDYLYLTRANSFERASE (Burkholderiavietnamiensis) |
PF00483(NTP_transferase) | 3 | THR A 81THR A 56PRO A 83 | None | 0.84A | 1a7yB-5ifyA:undetectable | 1a7yB-5ifyA:6.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwb | TYPE IINADH:UBIQUINONEOXIDOREDUCTASE (Plasmodiumfalciparum) |
PF07992(Pyr_redox_2) | 3 | THR A 394THR A 392PRO A 396 | None | 0.83A | 1a7yB-5jwbA:undetectable | 1a7yB-5jwbA:3.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lj3 | PRE-MRNA-SPLICINGFACTOR BUD31 (Saccharomycescerevisiae) |
PF01125(G10) | 3 | THR L 22THR L 24PRO L 21 | None | 0.86A | 1a7yB-5lj3L:undetectable | 1a7yB-5lj3L:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m1m | MATRIX PROTEIN 1 (Influenza Cvirus) |
PF03026(CM1) | 3 | THR A 23THR A 21PRO A 19 | None | 0.80A | 1a7yB-5m1mA:undetectable | 1a7yB-5m1mA:9.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqz | PUTATIVEBRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Archaeoglobusfulgidus) |
no annotation | 3 | THR A 228THR A 199PRO A 201 | TAM A 303 (-3.9A)NoneNone | 0.86A | 1a7yB-5mqzA:undetectable | 1a7yB-5mqzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | GENERALTRANSCRIPTION FACTORIIH SUBUNIT4,P52,GENERALTRANSCRIPTION FACTORIIH SUBUNIT 4 (Homo sapiens) |
no annotation | 3 | THR D 386THR D 388PRO D 385 | None | 0.78A | 1a7yB-5of4D:undetectable | 1a7yB-5of4D:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tte | E3 UBIQUITIN-PROTEINLIGASE ARIH1 (Homo sapiens) |
PF01485(IBR) | 3 | THR B 129THR B 131PRO B 127 | None | 0.71A | 1a7yB-5tteB:undetectable | 1a7yB-5tteB:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5udh | E3 UBIQUITIN-PROTEINLIGASE ARIH1 (Homo sapiens) |
PF01485(IBR) | 3 | THR A 129THR A 131PRO A 127 | None | 0.83A | 1a7yB-5udhA:undetectable | 1a7yB-5udhA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ujz | SCFV (Homo sapiens) |
PF07686(V-set) | 3 | THR G 10THR G 104PRO G 8 | None | 0.80A | 1a7yB-5ujzG:undetectable | 1a7yB-5ujzG:3.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 3 | THR A 505THR A 502PRO A 504 | None | 0.75A | 1a7yB-5w1uA:undetectable | 1a7yB-5w1uA:2.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyn | PLATINUM SENSITIVITYPROTEIN 3 (Saccharomycescerevisiae) |
no annotation | 3 | THR A 182THR A 209PRO A 181 | None | 0.85A | 1a7yB-5xynA:undetectable | 1a7yB-5xynA:3.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 3 | THR A1074THR A1076PRO A1073 | None | 0.83A | 1a7yB-6bq1A:undetectable | 1a7yB-6bq1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cri | - (-) |
no annotation | 3 | THR M 152THR M 154PRO M 150 | None | 0.86A | 1a7yB-6criM:undetectable | 1a7yB-6criM:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | PROTEIN CFT1 (Saccharomycescerevisiae) |
no annotation | 3 | THR A1086THR A1051PRO A1050 | None | 0.86A | 1a7yB-6eojA:undetectable | 1a7yB-6eojA:1.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fa5 | PUTATIVE MRNASPLICING FACTOR (Chaetomiumthermophilum) |
no annotation | 3 | THR A 349THR A 395PRO A 351 | None | 0.88A | 1a7yB-6fa5A:undetectable | 1a7yB-6fa5A:undetectable |