SIMILAR PATTERNS OF AMINO ACIDS FOR 1A7Y_B_DVAB8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)


(Pseudomonas
fluorescens)
PF01494
(FAD_binding_3)
3 THR A 217
THR A 192
PRO A 194
None
0.73A 1a7yB-1cj2A:
undetectable
1a7yB-1cj2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.)
PF00067
(p450)
3 THR A 111
THR A 109
PRO A 107
None
0.72A 1a7yB-1cptA:
undetectable
1a7yB-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0b SWI6 PROTEIN

(Schizosaccharomyces
pombe)
PF01393
(Chromo_shadow)
3 THR A 304
THR A 306
PRO A 302
None
0.87A 1a7yB-1e0bA:
undetectable
1a7yB-1e0bA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT


(Desulfovibrio
desulfuricans)
PF00374
(NiFeSe_Hases)
3 THR B 492
THR B 493
PRO B 491
FNE  B 543 (-3.8A)
None
FNE  B 543 (-3.7A)
0.85A 1a7yB-1e3dB:
undetectable
1a7yB-1e3dB:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE


(Streptomyces
clavuligerus)
PF00491
(Arginase)
3 THR A 149
THR A 162
PRO A 151
None
0.88A 1a7yB-1gq7A:
undetectable
1a7yB-1gq7A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME


(Homo sapiens)
PF00390
(malic)
PF03949
(Malic_M)
3 THR A 113
THR A 115
PRO A 109
None
0.83A 1a7yB-1gz4A:
undetectable
1a7yB-1gz4A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H  62
THR H  64
PRO H  60
None
0.74A 1a7yB-1h3pH:
undetectable
1a7yB-1h3pH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE


(Sus scrofa)
PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21)
3 THR A 554
THR A 555
PRO A 553
None
0.83A 1a7yB-1h7wA:
undetectable
1a7yB-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE


(Homo sapiens)
PF13460
(NAD_binding_10)
3 THR A 199
THR A 166
PRO A 201
None
0.83A 1a7yB-1he3A:
undetectable
1a7yB-1he3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
3 THR A 147
THR A 149
PRO A 146
None
0.87A 1a7yB-1j3uA:
undetectable
1a7yB-1j3uA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
3 THR A  99
THR A  97
PRO A  95
None
0.81A 1a7yB-1jioA:
undetectable
1a7yB-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)


(Escherichia
coli)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1)
3 THR A 688
THR A 687
PRO A 614
None
0.81A 1a7yB-1qafA:
undetectable
1a7yB-1qafA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqh PAPILLOMAVIRUS
TRANSCRIPTION FACTOR
E2


(Alphapapillomavirus
7)
PF00508
(PPV_E2_N)
3 THR A 107
THR A 104
PRO A 106
None
0.84A 1a7yB-1qqhA:
undetectable
1a7yB-1qqhA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus)
PF13242
(Hydrolase_like)
3 THR A 243
THR A 245
PRO A 241
None
0.77A 1a7yB-1qyiA:
undetectable
1a7yB-1qyiA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tue REGULATORY PROTEIN
E2


(Alphapapillomavirus
7)
PF00508
(PPV_E2_N)
3 THR B 111
THR B 108
PRO B 110
None
0.87A 1a7yB-1tueB:
undetectable
1a7yB-1tueB:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujt KIAA1568 PROTEIN

(Homo sapiens)
PF00041
(fn3)
3 THR A 112
THR A 111
PRO A  29
None
0.83A 1a7yB-1ujtA:
undetectable
1a7yB-1ujtA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
3 THR A1035
THR A1032
PRO A1034
None
0.87A 1a7yB-1ux6A:
undetectable
1a7yB-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)


(Mycobacterium
tuberculosis)
PF03405
(FA_desaturase_2)
3 THR A  64
THR A  66
PRO A  62
None
0.87A 1a7yB-1za0A:
undetectable
1a7yB-1za0A:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
3 THR C 241
THR C  37
PRO C  36
None
0.85A 1a7yB-1zrtC:
undetectable
1a7yB-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d07 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE


(Homo sapiens)
PF03167
(UDG)
3 THR A 121
THR A 196
PRO A 198
None
0.85A 1a7yB-2d07A:
undetectable
1a7yB-2d07A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzj SYNAPTIC
GLYCOPROTEIN SC2


(Homo sapiens)
no annotation 3 THR A  46
THR A  44
PRO A  48
None
0.82A 1a7yB-2dzjA:
undetectable
1a7yB-2dzjA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana)
PF00291
(PALP)
3 THR A 187
THR A 185
PRO A 154
None
PLP  A 400 (-3.6A)
None
0.88A 1a7yB-2isqA:
undetectable
1a7yB-2isqA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnu REGULATORY PROTEIN
E2


(Alphapapillomavirus
9)
PF00508
(PPV_E2_N)
3 THR A 107
THR A 104
PRO A 106
None
0.72A 1a7yB-2nnuA:
undetectable
1a7yB-2nnuA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE


(Corynebacterium
glutamicum)
PF00483
(NTP_transferase)
3 THR A  32
THR A  30
PRO A  34
None
0.79A 1a7yB-2pa4A:
undetectable
1a7yB-2pa4A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF16073
(SAT)
3 THR B  55
THR B  56
PRO B  54
None
0.80A 1a7yB-2pffB:
undetectable
1a7yB-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE


(Rhodococcus
jostii)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
3 THR A 236
THR A 237
PRO A 235
None
0.87A 1a7yB-2rfqA:
undetectable
1a7yB-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs5 HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP2)


(Rhinovirus B)
PF00073
(Rhv)
3 THR 2 147
THR 2 145
PRO 2 149
None
0.81A 1a7yB-2rs52:
undetectable
1a7yB-2rs52:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN


(Rattus
norvegicus)
PF00012
(HSP70)
3 THR A  64
THR A  66
PRO A  63
None
0.85A 1a7yB-2v7zA:
undetectable
1a7yB-2v7zA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens)
PF07679
(I-set)
PF13927
(Ig_3)
3 THR A 228
THR A 230
PRO A 186
None
0.76A 1a7yB-2v9qA:
undetectable
1a7yB-2v9qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2


(Streptomyces
fradiae)
PF08659
(KR)
3 THR A  36
THR A  37
PRO A  35
None
0.79A 1a7yB-2z5lA:
undetectable
1a7yB-2z5lA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Homo sapiens)
PF01593
(Amino_oxidase)
3 THR A 276
THR A 278
PRO A 274
None
None
FAD  A 600 ( 4.9A)
0.77A 1a7yB-2z5xA:
undetectable
1a7yB-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE


(Flavobacterium
sp.)
PF00144
(Beta-lactamase)
3 THR A 320
THR A 318
PRO A 322
None
0.86A 1a7yB-2zm2A:
undetectable
1a7yB-2zm2A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
3 THR A 115
THR A 113
PRO A 117
None
0.77A 1a7yB-3ai7A:
undetectable
1a7yB-3ai7A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT


(Hydrogenovibrio
marinus)
PF00374
(NiFeSe_Hases)
3 THR A 546
THR A 547
PRO A 545
CYN  A 605 (-3.7A)
None
CYN  A 605 ( 3.6A)
0.83A 1a7yB-3ayxA:
undetectable
1a7yB-3ayxA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3


(Saccharomyces
cerevisiae)
PF03571
(Peptidase_M49)
3 THR A 238
THR A 236
PRO A 240
None
0.73A 1a7yB-3cskA:
undetectable
1a7yB-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacteroides
fragilis)
PF13419
(HAD_2)
3 THR A  94
THR A  96
PRO A  93
None
0.87A 1a7yB-3d6jA:
undetectable
1a7yB-3d6jA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens)
PF00626
(Gelsolin)
3 THR A 702
THR A 704
PRO A 700
None
0.85A 1a7yB-3fg6A:
undetectable
1a7yB-3fg6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ


(Carboxydothermus
hydrogenoformans)
PF14450
(FtsA)
3 THR A 147
THR A 166
PRO A 165
None
0.75A 1a7yB-3h1qA:
undetectable
1a7yB-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
3 THR A 109
THR A 108
PRO A   4
None
0.85A 1a7yB-3hd8A:
undetectable
1a7yB-3hd8A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00476
(DNA_pol_A)
3 THR A 636
THR A 638
PRO A 635
None
0.75A 1a7yB-3ikmA:
undetectable
1a7yB-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)


(Helicobacter
pylori)
PF00483
(NTP_transferase)
3 THR A  22
THR A  20
PRO A  24
None
0.87A 1a7yB-3jujA:
undetectable
1a7yB-3jujA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE


(Nostoc
punctiforme)
PF00903
(Glyoxalase)
3 THR A  54
THR A  56
PRO A  52
None
0.86A 1a7yB-3kolA:
undetectable
1a7yB-3kolA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei)
PF13847
(Methyltransf_31)
3 THR A 248
THR A 254
PRO A 150
None
0.84A 1a7yB-3mggA:
undetectable
1a7yB-3mggA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
3 THR A 127
THR A 129
PRO A 125
None
0.70A 1a7yB-3nz4A:
undetectable
1a7yB-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc9 UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE


(Entamoeba
histolytica)
PF01704
(UDPGP)
3 THR A  12
THR A  10
PRO A  14
None
0.83A 1a7yB-3oc9A:
undetectable
1a7yB-3oc9A:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
3 THR A  69
THR A  70
PRO A 425
None
0.81A 1a7yB-3oksA:
undetectable
1a7yB-3oksA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens)
PF13927
(Ig_3)
3 THR A 410
THR A 367
PRO A 366
None
0.81A 1a7yB-3p40A:
undetectable
1a7yB-3p40A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
3 THR A 268
THR A 270
PRO A 266
None
0.70A 1a7yB-3q1yA:
undetectable
1a7yB-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
3 THR A  76
THR A  77
PRO A 426
None
0.83A 1a7yB-3q8nA:
undetectable
1a7yB-3q8nA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT


(Mycobacterium
marinum)
PF00202
(Aminotran_3)
3 THR A  68
THR A  69
PRO A 424
None
0.80A 1a7yB-3r4tA:
undetectable
1a7yB-3r4tA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
3 THR L 553
THR L 554
PRO L 552
NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
0.84A 1a7yB-3rgwL:
undetectable
1a7yB-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)


(Triticum
aestivum)
PF00450
(Peptidase_S10)
3 THR B 344
THR B 346
PRO B 342
None
0.66A 1a7yB-3sc2B:
undetectable
1a7yB-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN


(Escherichia
coli)
PF00374
(NiFeSe_Hases)
3 THR L 532
THR L 533
PRO L 531
FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
0.81A 1a7yB-3uscL:
undetectable
1a7yB-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsu TLL2057 PROTEIN

(Thermosynechococcus
elongatus)
no annotation 3 THR A 103
THR A 105
PRO A 102
None
0.84A 1a7yB-3zsuA:
undetectable
1a7yB-3zsuA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP


(Thermotoga
maritima)
PF03030
(H_PPase)
3 THR A 421
THR A 423
PRO A 420
None
0.81A 1a7yB-4av6A:
undetectable
1a7yB-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 3 THR A 295
THR A 297
PRO A 299
None
0.71A 1a7yB-4btpA:
undetectable
1a7yB-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC


(Homo sapiens)
PF00063
(Myosin_head)
PF00612
(IQ)
3 THR A 650
THR A 647
PRO A 649
None
0.87A 1a7yB-4byfA:
undetectable
1a7yB-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT


(Salmonella
enterica)
PF00374
(NiFeSe_Hases)
3 THR A 535
THR A 536
PRO A 534
NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
0.84A 1a7yB-4c3oA:
undetectable
1a7yB-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 THR A 250
THR A 248
PRO A 252
None
0.78A 1a7yB-4dzaA:
undetectable
1a7yB-4dzaA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF09455
(Cas_DxTHG)
3 THR A 174
THR A 176
PRO A 173
None
0.80A 1a7yB-4eogA:
undetectable
1a7yB-4eogA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2


(Danio rerio)
PF03372
(Exo_endo_phos)
3 THR A 210
THR A 211
PRO A 209
None
0.80A 1a7yB-4f1hA:
undetectable
1a7yB-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
caccae)
PF07523
(Big_3)
PF13306
(LRR_5)
3 THR A 193
THR A 217
PRO A 192
None
0.80A 1a7yB-4fd0A:
undetectable
1a7yB-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)


(Mycobacteroides
abscessus)
PF00202
(Aminotran_3)
3 THR A  72
THR A  73
PRO A 423
None
0.79A 1a7yB-4ffcA:
undetectable
1a7yB-4ffcA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
3 THR A 149
THR A 148
PRO A 145
None
P6G  A 305 ( 4.5A)
None
0.80A 1a7yB-4h16A:
undetectable
1a7yB-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k24 ANTI-UPAR ANTIBODY,
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H 116
THR H 117
PRO H 147
None
0.84A 1a7yB-4k24H:
undetectable
1a7yB-4k24H:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
3 THR A 310
THR A 308
PRO A 306
None
0.75A 1a7yB-4lmpA:
undetectable
1a7yB-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Chromohalobacter
salexigens)
PF03480
(DctP)
3 THR A 200
THR A 202
PRO A 198
None
0.78A 1a7yB-4n8gA:
undetectable
1a7yB-4n8gA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
3 THR A 257
THR A 259
PRO A 255
None
0.80A 1a7yB-4ovjA:
undetectable
1a7yB-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae)
PF01095
(Pectinesterase)
3 THR A 143
THR A 111
PRO A 113
None
0.79A 1a7yB-4pmhA:
undetectable
1a7yB-4pmhA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile)
PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore)
3 THR A 728
THR A 726
PRO A 730
None
0.87A 1a7yB-4r04A:
undetectable
1a7yB-4r04A:
0.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN


(Pectobacterium
atrosepticum)
PF13416
(SBP_bac_8)
3 THR A 165
THR A 301
PRO A 303
None
0.88A 1a7yB-4ry1A:
undetectable
1a7yB-4ry1A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
3 THR A 162
THR A 166
PRO A 168
None
0.82A 1a7yB-4s3jA:
undetectable
1a7yB-4s3jA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA


(Bacillus
subtilis)
PF11638
(DnaA_N)
3 THR B  31
THR B  44
PRO B  46
None
0.84A 1a7yB-4tpsB:
undetectable
1a7yB-4tpsB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans)
PF00730
(HhH-GPD)
3 THR A 152
THR A 150
PRO A 154
None
0.79A 1a7yB-4uobA:
undetectable
1a7yB-4uobA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens)
PF03283
(PAE)
3 THR A 284
THR A 282
PRO A 287
None
0.85A 1a7yB-4uz1A:
undetectable
1a7yB-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnz LIGHT CHAIN OF
ANTIBODY VRC06B


(Homo sapiens)
no annotation 3 THR L  10
THR L  97
PRO L   8
None
0.87A 1a7yB-4xnzL:
undetectable
1a7yB-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)


(Chaetomium)
PF13472
(Lipase_GDSL_2)
3 THR A 288
THR A 285
PRO A 287
None
0.78A 1a7yB-4xvhA:
undetectable
1a7yB-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS


(Bartonella
clarridgeiae)
no annotation 3 THR A 131
THR A 129
PRO A 134
None
0.81A 1a7yB-4yk2A:
undetectable
1a7yB-4yk2A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ac9 VP1

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
3 THR 1  68
THR 1  70
PRO 1 188
None
0.84A 1a7yB-5ac91:
undetectable
1a7yB-5ac91:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2


(Saccharomyces
cerevisiae)
PF16843
(Get5_bdg)
3 THR D  21
THR D  23
PRO D  25
None
0.75A 1a7yB-5bw8D:
undetectable
1a7yB-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
3 THR D1944
THR D1946
PRO D1943
None
0.87A 1a7yB-5disD:
undetectable
1a7yB-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis)
PF03415
(Peptidase_C11)
3 THR B 388
THR B 282
PRO B 278
None
0.82A 1a7yB-5dynB:
undetectable
1a7yB-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI


(Homo sapiens)
PF00024
(PAN_1)
PF00089
(Trypsin)
3 THR A 393
THR A 390
PRO A 392
None
0.80A 1a7yB-5eodA:
undetectable
1a7yB-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris)
PF12783
(Sec7_N)
PF16213
(DCB)
3 THR A  66
THR A  64
PRO A  62
None
0.73A 1a7yB-5hasA:
undetectable
1a7yB-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB


(Bacillus
subtilis)
PF01638
(HxlR)
3 THR A  41
THR A  39
PRO A  43
None
0.62A 1a7yB-5hs8A:
undetectable
1a7yB-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Burkholderia
vietnamiensis)
PF00483
(NTP_transferase)
3 THR A  81
THR A  56
PRO A  83
None
0.84A 1a7yB-5ifyA:
undetectable
1a7yB-5ifyA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE


(Plasmodium
falciparum)
PF07992
(Pyr_redox_2)
3 THR A 394
THR A 392
PRO A 396
None
0.83A 1a7yB-5jwbA:
undetectable
1a7yB-5jwbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31


(Saccharomyces
cerevisiae)
PF01125
(G10)
3 THR L  22
THR L  24
PRO L  21
None
0.86A 1a7yB-5lj3L:
undetectable
1a7yB-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1m MATRIX PROTEIN 1

(Influenza C
virus)
PF03026
(CM1)
3 THR A  23
THR A  21
PRO A  19
None
0.80A 1a7yB-5m1mA:
undetectable
1a7yB-5m1mA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Archaeoglobus
fulgidus)
no annotation 3 THR A 228
THR A 199
PRO A 201
TAM  A 303 (-3.9A)
None
None
0.86A 1a7yB-5mqzA:
undetectable
1a7yB-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4


(Homo sapiens)
no annotation 3 THR D 386
THR D 388
PRO D 385
None
0.78A 1a7yB-5of4D:
undetectable
1a7yB-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
3 THR B 129
THR B 131
PRO B 127
None
0.71A 1a7yB-5tteB:
undetectable
1a7yB-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
3 THR A 129
THR A 131
PRO A 127
None
0.83A 1a7yB-5udhA:
undetectable
1a7yB-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens)
PF07686
(V-set)
3 THR G  10
THR G 104
PRO G   8
None
0.80A 1a7yB-5ujzG:
undetectable
1a7yB-5ujzG:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
3 THR A 505
THR A 502
PRO A 504
None
0.75A 1a7yB-5w1uA:
undetectable
1a7yB-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3


(Saccharomyces
cerevisiae)
no annotation 3 THR A 182
THR A 209
PRO A 181
None
0.85A 1a7yB-5xynA:
undetectable
1a7yB-5xynA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 3 THR A1074
THR A1076
PRO A1073
None
0.83A 1a7yB-6bq1A:
undetectable
1a7yB-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-)
no annotation 3 THR M 152
THR M 154
PRO M 150
None
0.86A 1a7yB-6criM:
undetectable
1a7yB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae)
no annotation 3 THR A1086
THR A1051
PRO A1050
None
0.86A 1a7yB-6eojA:
undetectable
1a7yB-6eojA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR


(Chaetomium
thermophilum)
no annotation 3 THR A 349
THR A 395
PRO A 351
None
0.88A 1a7yB-6fa5A:
undetectable
1a7yB-6fa5A:
undetectable