SIMILAR PATTERNS OF AMINO ACIDS FOR 1A7Y_B_DVAB2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum)
PF00314
(Thaumatin)
3 THR A 190
PRO A 187
THR A 188
None
0.81A 1a7yB-1aunA:
undetectable
1a7yB-1aunA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 THR A 117
PRO A 224
THR A 223
None
0.87A 1a7yB-1bhgA:
undetectable
1a7yB-1bhgA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.)
PF00067
(p450)
3 THR A 109
PRO A 107
THR A 111
None
0.79A 1a7yB-1cptA:
undetectable
1a7yB-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei)
PF00840
(Glyco_hydro_7)
3 THR A   5
PRO A   8
THR A   7
None
0.76A 1a7yB-1eg1A:
undetectable
1a7yB-1eg1A:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
3 THR A 194
PRO A 192
THR A 193
None
0.87A 1a7yB-1fuuA:
undetectable
1a7yB-1fuuA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H  64
PRO H  60
THR H  62
None
0.85A 1a7yB-1h3pH:
undetectable
1a7yB-1h3pH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE


(Sus scrofa)
PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21)
3 THR A 555
PRO A 553
THR A 554
None
0.86A 1a7yB-1h7wA:
undetectable
1a7yB-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3e SEQA PROTEIN

(Escherichia
coli)
PF03925
(SeqA)
3 THR A  84
PRO A  72
THR A  70
None
0.85A 1a7yB-1j3eA:
undetectable
1a7yB-1j3eA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
3 THR A 149
PRO A 146
THR A 147
None
0.85A 1a7yB-1j3uA:
undetectable
1a7yB-1j3uA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
3 THR A  97
PRO A  95
THR A  99
None
0.82A 1a7yB-1jioA:
undetectable
1a7yB-1jioA:
7.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kj0 SERINE PROTEASE
INHIBITOR I


(Schistocerca
gregaria)
PF05375
(Pacifastin_I)
3 THR A   5
PRO A  21
THR A  20
None
0.81A 1a7yB-1kj0A:
undetectable
1a7yB-1kj0A:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrr SEQA PROTEIN

(Escherichia
coli)
PF03925
(SeqA)
3 THR A 149
PRO A 137
THR A 135
None
0.83A 1a7yB-1lrrA:
undetectable
1a7yB-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE


(Pyrococcus
abyssi)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 139
PRO A 136
THR A 137
None
0.86A 1a7yB-1ml4A:
undetectable
1a7yB-1ml4A:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA


(Mycobacterium
tuberculosis)
PF01625
(PMSR)
3 THR A  63
PRO A  60
THR A  61
None
0.87A 1a7yB-1nwaA:
undetectable
1a7yB-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus)
PF13242
(Hydrolase_like)
3 THR A 245
PRO A 241
THR A 243
None
0.81A 1a7yB-1qyiA:
undetectable
1a7yB-1qyiA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS


(Escherichia
coli)
PF01614
(IclR)
3 THR A 100
PRO A  98
THR A  99
None
0.83A 1a7yB-1tf1A:
undetectable
1a7yB-1tf1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Arabidopsis
thaliana)
PF00903
(Glyoxalase)
3 THR A  95
PRO A  93
THR A  94
None
0.88A 1a7yB-1tg5A:
undetectable
1a7yB-1tg5A:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
3 THR A1032
PRO A1034
THR A1035
None
0.70A 1a7yB-1ux6A:
undetectable
1a7yB-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI


(Homo sapiens)
PF00089
(Trypsin)
3 THR A  36
PRO A  37
THR A  37
None
0.63A 1a7yB-1zlrA:
undetectable
1a7yB-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zn6 PHAGE-RELATED
CONSERVED
HYPOTHETICAL PROTEIN


(Bordetella
bronchiseptica)
PF02586
(SRAP)
3 THR A 201
PRO A 197
THR A 199
None
0.83A 1a7yB-1zn6A:
undetectable
1a7yB-1zn6A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
3 THR C  37
PRO C  36
THR C 241
None
0.83A 1a7yB-1zrtC:
undetectable
1a7yB-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwt MAJOR STRUCTURAL
SUBUNIT OF
BUNDLE-FORMING PILUS


(Escherichia
coli)
PF05307
(Bundlin)
3 THR A  99
PRO A 137
THR A 136
None
0.88A 1a7yB-1zwtA:
undetectable
1a7yB-1zwtA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE


(Pestivirus A)
PF00998
(RdRP_3)
3 THR A 573
PRO A 575
THR A 574
None
0.83A 1a7yB-2cjqA:
undetectable
1a7yB-2cjqA:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE


(Phanerochaete
chrysosporium)
no annotation 3 THR A 252
PRO A 100
THR A  98
None
0.85A 1a7yB-2cl2A:
undetectable
1a7yB-2cl2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksk SUGARCANE DEFENSIN 5

(Saccharum
officinarum)
PF00304
(Gamma-thionin)
3 THR A   2
PRO A   5
THR A   4
None
0.82A 1a7yB-2kskA:
undetectable
1a7yB-2kskA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljp RIBONUCLEASE P
PROTEIN COMPONENT


(Escherichia
coli)
PF00825
(Ribonuclease_P)
3 THR A  34
PRO A  31
THR A  30
None
0.84A 1a7yB-2ljpA:
undetectable
1a7yB-2ljpA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens)
PF07679
(I-set)
PF13927
(Ig_3)
3 THR A 230
PRO A 186
THR A 228
None
0.89A 1a7yB-2v9qA:
undetectable
1a7yB-2v9qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus)
PF03583
(LIP)
3 THR A  23
PRO A  25
THR A  24
None
0.88A 1a7yB-2veoA:
undetectable
1a7yB-2veoA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A


(Deinococcus
radiodurans)
PF00005
(ABC_tran)
3 THR A 762
PRO A 760
THR A 761
None
0.86A 1a7yB-2vf8A:
undetectable
1a7yB-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmp PAPG PROTEIN

(Escherichia
coli)
PF03628
(PapG_C)
3 THR B 243
PRO B 245
THR B 244
None
0.86A 1a7yB-2wmpB:
undetectable
1a7yB-2wmpB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3q INTERLEUKIN-15
RECEPTOR ALPHA CHAIN


(Homo sapiens)
no annotation 3 THR B  57
PRO B  59
THR B  58
None
0.84A 1a7yB-2z3qB:
undetectable
1a7yB-2z3qB:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2


(Streptomyces
fradiae)
PF08659
(KR)
3 THR A  37
PRO A  35
THR A  36
None
0.83A 1a7yB-2z5lA:
undetectable
1a7yB-2z5lA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Homo sapiens)
PF01593
(Amino_oxidase)
3 THR A 278
PRO A 274
THR A 276
None
FAD  A 600 ( 4.9A)
None
0.79A 1a7yB-2z5xA:
undetectable
1a7yB-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
3 THR A 266
PRO A 269
THR A 268
None
0.87A 1a7yB-3aupA:
undetectable
1a7yB-3aupA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
3 THR A 121
PRO A 151
THR A 150
None
0.88A 1a7yB-3cmuA:
undetectable
1a7yB-3cmuA:
0.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
3 THR A1121
PRO A1151
THR A1150
None
0.89A 1a7yB-3cmuA:
undetectable
1a7yB-3cmuA:
0.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
3 THR A2121
PRO A2151
THR A2150
None
0.89A 1a7yB-3cmuA:
undetectable
1a7yB-3cmuA:
0.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
3 THR A5121
PRO A5151
THR A5150
None
0.89A 1a7yB-3cmuA:
undetectable
1a7yB-3cmuA:
0.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens)
PF00626
(Gelsolin)
3 THR A 704
PRO A 700
THR A 702
None
0.77A 1a7yB-3fg6A:
undetectable
1a7yB-3fg6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmt PROTEIN SEQA

(Escherichia
coli)
PF03925
(SeqA)
PF17206
(SeqA_N)
3 THR A 149
PRO A 137
THR A 135
None
0.87A 1a7yB-3fmtA:
undetectable
1a7yB-3fmtA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN


(Drosophila
melanogaster)
PF00989
(PAS)
PF14598
(PAS_11)
3 THR A 254
PRO A 256
THR A 255
None
0.84A 1a7yB-3gecA:
undetectable
1a7yB-3gecA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ


(Carboxydothermus
hydrogenoformans)
PF14450
(FtsA)
3 THR A 166
PRO A 165
THR A 147
None
0.85A 1a7yB-3h1qA:
undetectable
1a7yB-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hag CAPSID PROTEIN

(Orthohepevirus
A)
PF03014
(SP2)
3 THR A 217
PRO A 219
THR A 218
None
0.83A 1a7yB-3hagA:
undetectable
1a7yB-3hagA:
2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Herpetosiphon
aurantiacus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 THR A   4
PRO A   2
THR A   3
None
0.85A 1a7yB-3ik4A:
undetectable
1a7yB-3ik4A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00476
(DNA_pol_A)
3 THR A 638
PRO A 635
THR A 636
None
0.66A 1a7yB-3ikmA:
undetectable
1a7yB-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN


(Escherichia
coli)
PF13538
(UvrD_C_2)
PF13604
(AAA_30)
3 THR D 239
PRO D 204
THR D 205
None
0.84A 1a7yB-3k70D:
undetectable
1a7yB-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE


(Listeria
monocytogenes)
PF00171
(Aldedh)
3 THR A 124
PRO A 121
THR A 122
None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
0.77A 1a7yB-3k9dA:
undetectable
1a7yB-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE


(Nostoc
punctiforme)
PF00903
(Glyoxalase)
3 THR A  56
PRO A  52
THR A  54
None
0.87A 1a7yB-3kolA:
undetectable
1a7yB-3kolA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE


(Yersinia pestis)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 139
PRO A 136
THR A 137
None
0.82A 1a7yB-3lxmA:
undetectable
1a7yB-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8l CAPSID PROTEIN

(Feline
calicivirus)
PF00915
(Calici_coat)
3 THR A 131
PRO A 133
THR A 132
None
0.88A 1a7yB-3m8lA:
undetectable
1a7yB-3m8lA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei)
PF13847
(Methyltransf_31)
3 THR A 254
PRO A 150
THR A 248
None
0.88A 1a7yB-3mggA:
undetectable
1a7yB-3mggA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mh9 LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis)
no annotation 3 THR C 114
PRO C 117
THR C 116
None
0.87A 1a7yB-3mh9C:
undetectable
1a7yB-3mh9C:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mha LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis)
PF07161
(LppX_LprAFG)
3 THR A 114
PRO A 117
THR A 116
None
0.88A 1a7yB-3mhaA:
undetectable
1a7yB-3mhaA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE


(Vibrio
parahaemolyticus)
PF00171
(Aldedh)
3 THR A 119
PRO A 116
THR A 117
None
CL  A 453 ( 4.6A)
CL  A 453 ( 4.4A)
0.76A 1a7yB-3my7A:
undetectable
1a7yB-3my7A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
3 THR A 129
PRO A 125
THR A 127
None
0.74A 1a7yB-3nz4A:
undetectable
1a7yB-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II


(Streptococcus
suis)
PF00155
(Aminotran_1_2)
3 THR A 154
PRO A 152
THR A 153
None
0.89A 1a7yB-3op7A:
undetectable
1a7yB-3op7A:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens)
PF13927
(Ig_3)
3 THR A 367
PRO A 366
THR A 410
None
0.87A 1a7yB-3p40A:
undetectable
1a7yB-3p40A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
3 THR A 270
PRO A 266
THR A 268
None
0.87A 1a7yB-3q1yA:
undetectable
1a7yB-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf0 EXOPOLYPHOSPHATASE

(Yersinia pestis)
no annotation 3 THR A 146
PRO A 148
THR A 147
None
0.87A 1a7yB-3rf0A:
undetectable
1a7yB-3rf0A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)


(Triticum
aestivum)
PF00450
(Peptidase_S10)
3 THR B 346
PRO B 342
THR B 344
None
0.75A 1a7yB-3sc2B:
undetectable
1a7yB-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE


(Paecilomyces
sp.
'thermophila')
no annotation 3 THR A 248
PRO A  98
THR A  96
None
0.88A 1a7yB-3wdyA:
undetectable
1a7yB-3wdyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis)
PF03583
(LIP)
3 THR A  23
PRO A  25
THR A  24
None
0.87A 1a7yB-3zpxA:
undetectable
1a7yB-3zpxA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP


(Thermotoga
maritima)
PF03030
(H_PPase)
3 THR A 423
PRO A 420
THR A 421
None
0.85A 1a7yB-4av6A:
undetectable
1a7yB-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 3 THR A 297
PRO A 299
THR A 295
None
0.77A 1a7yB-4btpA:
undetectable
1a7yB-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 3 THR A 297
PRO A 299
THR A 298
None
0.89A 1a7yB-4btpA:
undetectable
1a7yB-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC


(Homo sapiens)
PF00063
(Myosin_head)
PF00612
(IQ)
3 THR A 647
PRO A 649
THR A 650
None
0.64A 1a7yB-4byfA:
undetectable
1a7yB-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cni INTERLEUKIN-6

(Homo sapiens)
PF00489
(IL6)
3 THR C 137
PRO C 139
THR C 138
None
0.86A 1a7yB-4cniC:
undetectable
1a7yB-4cniC:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2


(Danio rerio)
PF03372
(Exo_endo_phos)
3 THR A 211
PRO A 209
THR A 210
None
0.73A 1a7yB-4f1hA:
undetectable
1a7yB-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
3 THR A 268
PRO A 186
THR A 187
None
0.77A 1a7yB-4fnqA:
undetectable
1a7yB-4fnqA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE


(Thermothelomyces
thermophila)
no annotation 3 THR A 210
PRO A 234
THR A 232
None
0.87A 1a7yB-4g4iA:
undetectable
1a7yB-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k24 ANTI-UPAR ANTIBODY,
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H 117
PRO H 147
THR H 116
None
0.80A 1a7yB-4k24H:
undetectable
1a7yB-4k24H:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN


(Xylanimonas
cellulosilytica)
PF01471
(PG_binding_1)
PF03734
(YkuD)
3 THR A 248
PRO A 250
THR A 249
None
0.89A 1a7yB-4lpqA:
undetectable
1a7yB-4lpqA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Chromohalobacter
salexigens)
PF03480
(DctP)
3 THR A 202
PRO A 198
THR A 200
None
0.89A 1a7yB-4n8gA:
undetectable
1a7yB-4n8gA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh7 ORNITHINE
CARBAMOYLTRANSFERASE


(Brucella
melitensis)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 211
PRO A 187
THR A 186
None
0.85A 1a7yB-4oh7A:
undetectable
1a7yB-4oh7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
3 THR A 259
PRO A 255
THR A 257
None
0.74A 1a7yB-4ovjA:
undetectable
1a7yB-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 THR A 169
PRO A 172
THR A 171
None
0.88A 1a7yB-4qorA:
undetectable
1a7yB-4qorA:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
3 THR A 109
PRO A  75
THR A 111
PO4  A 401 (-4.1A)
None
None
0.87A 1a7yB-4u39A:
undetectable
1a7yB-4u39A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu9 MEDI7814

(Homo sapiens)
PF07686
(V-set)
3 THR B  95
PRO B  93
THR B  94
None
0.78A 1a7yB-4uu9B:
undetectable
1a7yB-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
3 THR A 305
PRO A 302
THR A 303
None
0.88A 1a7yB-4wzbA:
undetectable
1a7yB-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)


(Chaetomium)
PF13472
(Lipase_GDSL_2)
3 THR A 285
PRO A 287
THR A 288
None
0.58A 1a7yB-4xvhA:
undetectable
1a7yB-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
3 THR A 152
PRO A 187
THR A 186
None
0.89A 1a7yB-5ah5A:
undetectable
1a7yB-5ah5A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum)
PF00026
(Asp)
3 THR A 116
PRO A 113
THR A 114
None
0.73A 1a7yB-5bwyA:
undetectable
1a7yB-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF13476
(AAA_23)
3 THR A1241
PRO A1239
THR A1240
None
0.83A 1a7yB-5dacA:
undetectable
1a7yB-5dacA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
3 THR D1946
PRO D1943
THR D1944
None
0.71A 1a7yB-5disD:
undetectable
1a7yB-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis)
PF03415
(Peptidase_C11)
3 THR B 282
PRO B 278
THR B 388
None
0.78A 1a7yB-5dynB:
undetectable
1a7yB-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI


(Homo sapiens)
PF00024
(PAN_1)
PF00089
(Trypsin)
3 THR A 390
PRO A 392
THR A 393
None
0.70A 1a7yB-5eodA:
undetectable
1a7yB-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE


(Legionella
pneumophila)
PF04389
(Peptidase_M28)
3 THR A 321
PRO A 327
THR A 326
None
0.89A 1a7yB-5gneA:
undetectable
1a7yB-5gneA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB


(Bacillus
subtilis)
PF01638
(HxlR)
3 THR A  39
PRO A  43
THR A  41
None
0.84A 1a7yB-5hs8A:
undetectable
1a7yB-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)


(Parageobacillus
thermoglucosidasius)
PF00171
(Aldedh)
3 THR A 146
PRO A 143
THR A 144
None
ACT  A1005 (-3.9A)
ACT  A1005 (-3.3A)
0.72A 1a7yB-5j78A:
undetectable
1a7yB-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00171
(Aldedh)
3 THR A 203
PRO A 200
THR A 201
None
0.71A 1a7yB-5jfmA:
undetectable
1a7yB-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31


(Saccharomyces
cerevisiae)
PF01125
(G10)
3 THR L  24
PRO L  21
THR L  22
None
0.89A 1a7yB-5lj3L:
undetectable
1a7yB-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
3 THR A  69
PRO A  67
THR A  68
None
0.87A 1a7yB-5ngkA:
undetectable
1a7yB-5ngkA:
1.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4


(Homo sapiens)
no annotation 3 THR D 388
PRO D 385
THR D 386
None
0.64A 1a7yB-5of4D:
undetectable
1a7yB-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
3 THR B 131
PRO B 127
THR B 129
None
0.82A 1a7yB-5tteB:
undetectable
1a7yB-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens)
PF00117
(GATase)
PF06418
(CTP_synth_N)
3 THR A 428
PRO A 426
THR A 427
None
0.89A 1a7yB-5u03A:
undetectable
1a7yB-5u03A:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum)
no annotation 3 THR A   5
PRO A   8
THR A   7
THR  A   5 ( 0.8A)
PRO  A   8 ( 1.1A)
THR  A   7 ( 0.8A)
0.83A 1a7yB-5w0aA:
undetectable
1a7yB-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
3 THR A 502
PRO A 504
THR A 505
None
0.52A 1a7yB-5w1uA:
undetectable
1a7yB-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE


(Pseudomonas
putida)
no annotation 3 THR A 217
PRO A 193
THR A 192
None
0.88A 1a7yB-6dllA:
undetectable
1a7yB-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eio ANTIFREEZE PROTEIN

(uncultured
bacterium)
no annotation 3 THR A 210
PRO A 181
THR A 208
None
0.89A 1a7yB-6eioA:
undetectable
1a7yB-6eioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus)
no annotation 3 THR A1828
PRO A1820
THR A1826
None
0.87A 1a7yB-6fb3A:
undetectable
1a7yB-6fb3A:
undetectable