SIMILAR PATTERNS OF AMINO ACIDS FOR 1A7Y_A_DVAA8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis)
PF00082
(Peptidase_S8)
3 THR A 211
THR A 213
PRO A 210
None
0.86A 1a7yA-1c3lA:
undetectable
1a7yA-1c3lA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.)
PF00067
(p450)
3 THR A 111
THR A 109
PRO A 107
None
0.74A 1a7yA-1cptA:
undetectable
1a7yA-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT


(Desulfovibrio
desulfuricans)
PF00374
(NiFeSe_Hases)
3 THR B 492
THR B 493
PRO B 491
FNE  B 543 (-3.8A)
None
FNE  B 543 (-3.7A)
0.77A 1a7yA-1e3dB:
undetectable
1a7yA-1e3dB:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE


(Rhodobacter
sphaeroides)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
3 THR A 107
THR A 109
PRO A 106
None
0.83A 1a7yA-1eu1A:
undetectable
1a7yA-1eu1A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
3 THR B 766
THR B 768
PRO B 765
None
0.85A 1a7yA-1ffvB:
undetectable
1a7yA-1ffvB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE


(Sus scrofa)
PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21)
3 THR A 554
THR A 555
PRO A 553
None
0.73A 1a7yA-1h7wA:
undetectable
1a7yA-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE


(Homo sapiens)
PF13460
(NAD_binding_10)
3 THR A 199
THR A 166
PRO A 201
None
0.83A 1a7yA-1he3A:
undetectable
1a7yA-1he3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
3 THR A 147
THR A 149
PRO A 146
None
0.82A 1a7yA-1j3uA:
undetectable
1a7yA-1j3uA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
3 THR A  99
THR A  97
PRO A  95
None
0.77A 1a7yA-1jioA:
undetectable
1a7yA-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)


(Escherichia
coli)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1)
3 THR A 688
THR A 687
PRO A 614
None
0.81A 1a7yA-1qafA:
undetectable
1a7yA-1qafA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS


(Escherichia
coli)
PF01614
(IclR)
3 THR A  99
THR A 100
PRO A  98
None
0.83A 1a7yA-1tf1A:
undetectable
1a7yA-1tf1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Arabidopsis
thaliana)
PF00903
(Glyoxalase)
3 THR A  94
THR A  95
PRO A  93
None
0.79A 1a7yA-1tg5A:
undetectable
1a7yA-1tg5A:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
3 THR A1035
THR A1032
PRO A1034
None
0.81A 1a7yA-1ux6A:
undetectable
1a7yA-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN


(Bacillus
subtilis)
PF02113
(Peptidase_S13)
3 THR A 204
THR A 203
PRO A 230
None
0.82A 1a7yA-1w5dA:
undetectable
1a7yA-1w5dA:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI


(Homo sapiens)
PF00089
(Trypsin)
3 THR A  37
THR A  36
PRO A  37
None
0.83A 1a7yA-1zlrA:
undetectable
1a7yA-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
3 THR C 241
THR C  37
PRO C  36
None
0.86A 1a7yA-1zrtC:
undetectable
1a7yA-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
3 THR A 107
THR A 106
PRO A   2
None
0.82A 1a7yA-2b42A:
undetectable
1a7yA-2b42A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c34 INHIBITOR OF
CYSTEINE PEPTIDASES


(Leishmania
mexicana)
PF09394
(Inhibitor_I42)
3 THR A  31
THR A  32
PRO A  30
None
0.80A 1a7yA-2c34A:
undetectable
1a7yA-2c34A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1


(Salmonella
enterica)
no annotation 3 THR A 255
THR A 256
PRO A 247
None
0.85A 1a7yA-2d4yA:
undetectable
1a7yA-2d4yA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1)
PF01499
(Herpes_UL25)
3 THR A 188
THR A 186
PRO A 191
None
0.85A 1a7yA-2f5uA:
undetectable
1a7yA-2f5uA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana)
PF00291
(PALP)
3 THR A 187
THR A 185
PRO A 154
None
PLP  A 400 (-3.6A)
None
0.83A 1a7yA-2isqA:
undetectable
1a7yA-2isqA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgy POSSIBLE EXPORTED
PROTEIN


(Mycobacterium
tuberculosis)
no annotation 3 THR A  16
THR A  17
PRO A  15
None
0.83A 1a7yA-2kgyA:
undetectable
1a7yA-2kgyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvc OBSCURIN-LIKE
PROTEIN 1


(Homo sapiens)
PF13927
(Ig_3)
3 THR A  19
THR A  67
PRO A  69
None
0.85A 1a7yA-2lvcA:
undetectable
1a7yA-2lvcA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnu REGULATORY PROTEIN
E2


(Alphapapillomavirus
9)
PF00508
(PPV_E2_N)
3 THR A 107
THR A 104
PRO A 106
None
0.78A 1a7yA-2nnuA:
undetectable
1a7yA-2nnuA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF16073
(SAT)
3 THR B  55
THR B  56
PRO B  54
None
0.72A 1a7yA-2pffB:
undetectable
1a7yA-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A


(Geobacillus
stearothermophilus)
PF00005
(ABC_tran)
3 THR A 856
THR A 857
PRO A 855
None
0.79A 1a7yA-2r6fA:
undetectable
1a7yA-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE


(Rhodococcus
jostii)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
3 THR A 236
THR A 237
PRO A 235
None
0.78A 1a7yA-2rfqA:
undetectable
1a7yA-2rfqA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs5 HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP2)


(Rhinovirus B)
PF00073
(Rhv)
3 THR 2 147
THR 2 145
PRO 2 149
None
0.80A 1a7yA-2rs52:
undetectable
1a7yA-2rs52:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN


(Rattus
norvegicus)
PF00012
(HSP70)
3 THR A  64
THR A  66
PRO A  63
None
0.83A 1a7yA-2v7zA:
undetectable
1a7yA-2v7zA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens)
PF07679
(I-set)
PF13927
(Ig_3)
3 THR A 228
THR A 230
PRO A 186
None
0.70A 1a7yA-2v9qA:
undetectable
1a7yA-2v9qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A


(Deinococcus
radiodurans)
PF00005
(ABC_tran)
3 THR A 761
THR A 762
PRO A 760
None
0.83A 1a7yA-2vf8A:
undetectable
1a7yA-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgr GLUTATHIONE
PEROXIDASE


(Schistosoma
mansoni)
PF00255
(GSHPx)
3 THR A 152
THR A 153
PRO A 151
None
None
POP  A1170 (-4.4A)
0.82A 1a7yA-2wgrA:
undetectable
1a7yA-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA)
3 THR F 587
THR F 588
PRO F 586
None
0.84A 1a7yA-2xwbF:
undetectable
1a7yA-2xwbF:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2


(Streptomyces
fradiae)
PF08659
(KR)
3 THR A  36
THR A  37
PRO A  35
None
0.74A 1a7yA-2z5lA:
undetectable
1a7yA-2z5lA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Homo sapiens)
PF01593
(Amino_oxidase)
3 THR A 276
THR A 278
PRO A 274
None
None
FAD  A 600 ( 4.9A)
0.83A 1a7yA-2z5xA:
undetectable
1a7yA-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT


(Hydrogenovibrio
marinus)
PF00374
(NiFeSe_Hases)
3 THR A 546
THR A 547
PRO A 545
CYN  A 605 (-3.7A)
None
CYN  A 605 ( 3.6A)
0.74A 1a7yA-3ayxA:
undetectable
1a7yA-3ayxA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3


(Saccharomyces
cerevisiae)
PF03571
(Peptidase_M49)
3 THR A 238
THR A 236
PRO A 240
None
0.83A 1a7yA-3cskA:
undetectable
1a7yA-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacteroides
fragilis)
PF13419
(HAD_2)
3 THR A  94
THR A  96
PRO A  93
None
0.85A 1a7yA-3d6jA:
undetectable
1a7yA-3d6jA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ


(Carboxydothermus
hydrogenoformans)
PF14450
(FtsA)
3 THR A 147
THR A 166
PRO A 165
None
0.81A 1a7yA-3h1qA:
undetectable
1a7yA-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
3 THR A 109
THR A 108
PRO A   4
None
0.82A 1a7yA-3hd8A:
undetectable
1a7yA-3hd8A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Herpetosiphon
aurantiacus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 THR A   3
THR A   4
PRO A   2
None
0.84A 1a7yA-3ik4A:
undetectable
1a7yA-3ik4A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00476
(DNA_pol_A)
3 THR A 636
THR A 638
PRO A 635
None
0.78A 1a7yA-3ikmA:
undetectable
1a7yA-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq2 SORTING NEXIN-7

(Homo sapiens)
PF00787
(PX)
3 THR A 133
THR A 135
PRO A 132
None
0.85A 1a7yA-3iq2A:
undetectable
1a7yA-3iq2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE


(Listeria
monocytogenes)
PF00171
(Aldedh)
3 THR A 122
THR A 124
PRO A 121
CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
0.84A 1a7yA-3k9dA:
undetectable
1a7yA-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
3 THR A  20
THR A  21
PRO A  19
None
0.83A 1a7yA-3kh5A:
undetectable
1a7yA-3kh5A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE


(Yersinia pestis)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 137
THR A 139
PRO A 136
None
0.80A 1a7yA-3lxmA:
undetectable
1a7yA-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei)
PF13847
(Methyltransf_31)
3 THR A 248
THR A 254
PRO A 150
None
0.84A 1a7yA-3mggA:
undetectable
1a7yA-3mggA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis)
PF01979
(Amidohydro_1)
3 THR A 390
THR A 391
PRO A 389
None
0.85A 1a7yA-3mpgA:
undetectable
1a7yA-3mpgA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE


(Vibrio
parahaemolyticus)
PF00171
(Aldedh)
3 THR A 117
THR A 119
PRO A 116
CL  A 453 ( 4.4A)
None
CL  A 453 ( 4.6A)
0.83A 1a7yA-3my7A:
undetectable
1a7yA-3my7A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
3 THR A 127
THR A 129
PRO A 125
None
0.79A 1a7yA-3nz4A:
undetectable
1a7yA-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II


(Streptococcus
suis)
PF00155
(Aminotran_1_2)
3 THR A 153
THR A 154
PRO A 152
None
0.80A 1a7yA-3op7A:
undetectable
1a7yA-3op7A:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdm COAT PROTEIN

(Hibiscus latent
Singapore virus)
PF00721
(TMV_coat)
3 THR P 103
THR P 104
PRO P 102
None
0.82A 1a7yA-3pdmP:
undetectable
1a7yA-3pdmP:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
3 THR A 268
THR A 270
PRO A 266
None
0.82A 1a7yA-3q1yA:
undetectable
1a7yA-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
3 THR L 553
THR L 554
PRO L 552
NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
0.75A 1a7yA-3rgwL:
undetectable
1a7yA-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)


(Triticum
aestivum)
PF00450
(Peptidase_S10)
3 THR B 344
THR B 346
PRO B 342
None
0.73A 1a7yA-3sc2B:
undetectable
1a7yA-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN


(Escherichia
coli)
PF00374
(NiFeSe_Hases)
3 THR L 532
THR L 533
PRO L 531
FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
0.72A 1a7yA-3uscL:
undetectable
1a7yA-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsu TLL2057 PROTEIN

(Thermosynechococcus
elongatus)
no annotation 3 THR A 103
THR A 105
PRO A 102
None
0.83A 1a7yA-3zsuA:
undetectable
1a7yA-3zsuA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1r LIP

(Serratia
marcescens)
PF12790
(T6SS-SciN)
3 THR A 143
THR A 145
PRO A 142
None
0.84A 1a7yA-4a1rA:
undetectable
1a7yA-4a1rA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP


(Thermotoga
maritima)
PF03030
(H_PPase)
3 THR A 421
THR A 423
PRO A 420
None
0.77A 1a7yA-4av6A:
undetectable
1a7yA-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE


(Bacillus
subtilis)
PF13277
(YmdB)
3 THR A 232
THR A 233
PRO A 201
None
0.84A 1a7yA-4b2oA:
undetectable
1a7yA-4b2oA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 3 THR A 295
THR A 297
PRO A 299
None
0.66A 1a7yA-4btpA:
undetectable
1a7yA-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC


(Homo sapiens)
PF00063
(Myosin_head)
PF00612
(IQ)
3 THR A 650
THR A 647
PRO A 649
None
0.79A 1a7yA-4byfA:
undetectable
1a7yA-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT


(Salmonella
enterica)
PF00374
(NiFeSe_Hases)
3 THR A 535
THR A 536
PRO A 534
NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
0.76A 1a7yA-4c3oA:
undetectable
1a7yA-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF09455
(Cas_DxTHG)
3 THR A 174
THR A 176
PRO A 173
None
0.80A 1a7yA-4eogA:
undetectable
1a7yA-4eogA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2


(Danio rerio)
PF03372
(Exo_endo_phos)
3 THR A 210
THR A 211
PRO A 209
None
0.67A 1a7yA-4f1hA:
undetectable
1a7yA-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
3 THR A 187
THR A 268
PRO A 186
None
0.80A 1a7yA-4fnqA:
undetectable
1a7yA-4fnqA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
3 THR A 149
THR A 148
PRO A 145
None
P6G  A 305 ( 4.5A)
None
0.77A 1a7yA-4h16A:
undetectable
1a7yA-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k24 ANTI-UPAR ANTIBODY,
HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H 116
THR H 117
PRO H 147
None
0.74A 1a7yA-4k24H:
undetectable
1a7yA-4k24H:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2j OSMOTIN: ANTIFUNGAL
LATICIFER PROTEIN


(Calotropis
procera)
PF00314
(Thaumatin)
3 THR A 187
THR A 189
PRO A 186
None
0.86A 1a7yA-4l2jA:
undetectable
1a7yA-4l2jA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae)
PF01095
(Pectinesterase)
3 THR A 143
THR A 111
PRO A 113
None
0.79A 1a7yA-4pmhA:
undetectable
1a7yA-4pmhA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN


(Pectobacterium
atrosepticum)
PF13416
(SBP_bac_8)
3 THR A 165
THR A 301
PRO A 303
None
0.85A 1a7yA-4ry1A:
undetectable
1a7yA-4ry1A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
3 THR A 162
THR A 166
PRO A 168
None
0.83A 1a7yA-4s3jA:
undetectable
1a7yA-4s3jA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA


(Bacillus
subtilis)
PF11638
(DnaA_N)
3 THR B  31
THR B  44
PRO B  46
None
0.84A 1a7yA-4tpsB:
undetectable
1a7yA-4tpsB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens)
PF03283
(PAE)
3 THR A 284
THR A 282
PRO A 287
None
0.79A 1a7yA-4uz1A:
undetectable
1a7yA-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
3 THR A 303
THR A 305
PRO A 302
None
0.84A 1a7yA-4wzbA:
undetectable
1a7yA-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)


(Chaetomium)
PF13472
(Lipase_GDSL_2)
3 THR A 288
THR A 285
PRO A 287
None
0.69A 1a7yA-4xvhA:
undetectable
1a7yA-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2


(Saccharomyces
cerevisiae)
PF16843
(Get5_bdg)
3 THR D  21
THR D  23
PRO D  25
None
0.78A 1a7yA-5bw8D:
undetectable
1a7yA-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum)
PF00026
(Asp)
3 THR A 114
THR A 116
PRO A 113
None
0.81A 1a7yA-5bwyA:
undetectable
1a7yA-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF13476
(AAA_23)
3 THR A1240
THR A1241
PRO A1239
None
0.84A 1a7yA-5dacA:
undetectable
1a7yA-5dacA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
3 THR D1944
THR D1946
PRO D1943
None
0.71A 1a7yA-5disD:
undetectable
1a7yA-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis)
PF03415
(Peptidase_C11)
3 THR B 388
THR B 282
PRO B 278
None
0.78A 1a7yA-5dynB:
undetectable
1a7yA-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI


(Homo sapiens)
PF00024
(PAN_1)
PF00089
(Trypsin)
3 THR A 393
THR A 390
PRO A 392
None
0.71A 1a7yA-5eodA:
undetectable
1a7yA-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3j ANTIBODY 2D10 SINGLE
CHAIN VARIABLE
FRAGMENT


(Mus musculus)
PF07686
(V-set)
3 THR C 284
THR C 283
PRO C 178
None
0.84A 1a7yA-5f3jC:
undetectable
1a7yA-5f3jC:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foh POLYSACCHARIDE
MONOOXYGENASE


(Neurospora
crassa)
PF03443
(Glyco_hydro_61)
3 THR A  46
THR A  47
PRO A  23
None
0.81A 1a7yA-5fohA:
undetectable
1a7yA-5fohA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris)
PF12783
(Sec7_N)
PF16213
(DCB)
3 THR A  66
THR A  64
PRO A  62
None
0.75A 1a7yA-5hasA:
undetectable
1a7yA-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB


(Bacillus
subtilis)
PF01638
(HxlR)
3 THR A  41
THR A  39
PRO A  43
None
0.69A 1a7yA-5hs8A:
undetectable
1a7yA-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Burkholderia
vietnamiensis)
PF00483
(NTP_transferase)
3 THR A  81
THR A  56
PRO A  83
None
0.85A 1a7yA-5ifyA:
undetectable
1a7yA-5ifyA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)


(Parageobacillus
thermoglucosidasius)
PF00171
(Aldedh)
3 THR A 144
THR A 146
PRO A 143
ACT  A1005 (-3.3A)
None
ACT  A1005 (-3.9A)
0.81A 1a7yA-5j78A:
undetectable
1a7yA-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00171
(Aldedh)
3 THR A 201
THR A 203
PRO A 200
None
0.81A 1a7yA-5jfmA:
undetectable
1a7yA-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Legionella
pneumophila)
PF00290
(Trp_syntA)
3 THR A 157
THR A 158
PRO A 156
None
0.86A 1a7yA-5k9xA:
undetectable
1a7yA-5k9xA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l82 ENTEROCOCCIN K1

(Enterococcus
faecium)
no annotation 3 THR A   8
THR A  10
PRO A   7
None
0.86A 1a7yA-5l82A:
undetectable
1a7yA-5l82A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31


(Saccharomyces
cerevisiae)
PF01125
(G10)
3 THR L  22
THR L  24
PRO L  21
None
0.83A 1a7yA-5lj3L:
undetectable
1a7yA-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Archaeoglobus
fulgidus)
no annotation 3 THR A 228
THR A 199
PRO A 201
TAM  A 303 (-3.9A)
None
None
0.84A 1a7yA-5mqzA:
undetectable
1a7yA-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
3 THR A  68
THR A  69
PRO A  67
None
0.83A 1a7yA-5ngkA:
undetectable
1a7yA-5ngkA:
1.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4


(Homo sapiens)
no annotation 3 THR D 386
THR D 388
PRO D 385
None
0.74A 1a7yA-5of4D:
undetectable
1a7yA-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
3 THR B 129
THR B 131
PRO B 127
None
0.80A 1a7yA-5tteB:
undetectable
1a7yA-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
3 THR A 505
THR A 502
PRO A 504
None
0.64A 1a7yA-5w1uA:
undetectable
1a7yA-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3


(Saccharomyces
cerevisiae)
no annotation 3 THR A 182
THR A 209
PRO A 181
None
0.80A 1a7yA-5xynA:
undetectable
1a7yA-5xynA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-)
no annotation 3 THR A  63
THR A  64
PRO A  62
None
0.85A 1a7yA-6a8mA:
undetectable
1a7yA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 3 THR A1074
THR A1076
PRO A1073
None
0.78A 1a7yA-6bq1A:
undetectable
1a7yA-6bq1A:
undetectable