SIMILAR PATTERNS OF AMINO ACIDS FOR 1A7Y_A_DVAA2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3p MINOR COAT PROTEIN

(Escherichia
virus M13) 		PF05357
(Phage_Coat_A) 		4 THR A 149
PRO A 170
THR A 169
PRO A 112
 None
 1.40A 1a7yA-1g3pA:
undetectable
1a7yC-1g3pA:
undetectable		 1a7yA-1g3pA:
4.23
1a7yC-1g3pA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE

(Homo sapiens) 		PF13460
(NAD_binding_10) 		4 THR A 166
PRO A 201
THR A 199
PRO A 152
 None
None
None
MBV  A1207 ( 4.5A)
 0.90A 1a7yA-1he3A:
undetectable
1a7yC-1he3A:
undetectable		 1a7yA-1he3A:
20.00
1a7yC-1he3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		4 THR A 135
PRO A 132
THR A 131
PRO A 157
 None
 1.46A 1a7yA-1p8rA:
undetectable
1a7yC-1p8rA:
undetectable		 1a7yA-1p8rA:
3.81
1a7yC-1p8rA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 THR A 269
PRO A 176
THR A 177
PRO A 310
 None
 1.38A 1a7yA-1pgsA:
undetectable
1a7yC-1pgsA:
undetectable		 1a7yA-1pgsA:
6.49
1a7yC-1pgsA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 THR A 240
PRO A 229
THR A 228
PRO A 231
 SO4  A 941 ( 4.4A)
2TH  A 949 ( 4.8A)
None
None
 1.34A 1a7yA-2gj4A:
undetectable
1a7yC-2gj4A:
undetectable		 1a7yA-2gj4A:
1.25
1a7yC-2gj4A:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 THR A  75
PRO A  77
THR A  34
PRO A  37
 None
 1.23A 1a7yA-2q7sA:
undetectable
1a7yC-2q7sA:
undetectable		 1a7yA-2q7sA:
6.33
1a7yC-2q7sA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 THR A 321
PRO A 203
THR A 202
PRO A 316
 None
None
FAD  A 618 (-4.3A)
None
 1.42A 1a7yA-2zxhA:
undetectable
1a7yC-2zxhA:
undetectable		 1a7yA-2zxhA:
2.33
1a7yC-2zxhA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 THR A 186
PRO A 306
THR A 184
PRO A 405
 None
 1.49A 1a7yA-3bolA:
undetectable
1a7yC-3bolA:
undetectable		 1a7yA-3bolA:
2.60
1a7yC-3bolA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 THR A 240
PRO A 229
THR A 228
PRO A 231
 None
 1.37A 1a7yA-3cemA:
undetectable
1a7yC-3cemA:
undetectable		 1a7yA-3cemA:
2.15
1a7yC-3cemA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dte IRRE PROTEIN

(Deinococcus
deserti) 		PF06114
(Peptidase_M78) 		4 THR A 193
PRO A 212
THR A 211
PRO A 214
 None
 1.39A 1a7yA-3dteA:
undetectable
1a7yC-3dteA:
undetectable		 1a7yA-3dteA:
18.42
1a7yC-3dteA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r08 MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 HEAVY CHAIN

(Cricetulus
migratorius) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H 117
PRO H 149
THR H 116
PRO H 213
 None
 1.45A 1a7yA-3r08H:
undetectable
1a7yC-3r08H:
undetectable		 1a7yA-3r08H:
12.90
1a7yC-3r08H:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf0 EXOPOLYPHOSPHATASE

(Yersinia pestis) 		no annotation 4 THR A 146
PRO A 148
THR A 147
PRO A 165
 None
 1.34A 1a7yA-3rf0A:
undetectable
1a7yC-3rf0A:
undetectable		 1a7yA-3rf0A:
14.00
1a7yC-3rf0A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		4 THR A 391
PRO A 390
THR A 414
PRO A 357
 None
 1.27A 1a7yA-4hzsA:
undetectable
1a7yC-4hzsA:
undetectable		 1a7yA-4hzsA:
5.99
1a7yC-4hzsA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 THR A  32
PRO A  30
THR A  31
PRO A  52
 None
 1.24A 1a7yA-4i84A:
undetectable
1a7yC-4i84A:
undetectable		 1a7yA-4i84A:
3.38
1a7yC-4i84A:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m29 BETA-XYLOSIDASE

(Caulobacter
vibrioides) 		PF01229
(Glyco_hydro_39) 		4 THR A 227
PRO A 201
THR A 228
PRO A 164
 None
 1.16A 1a7yA-4m29A:
undetectable
1a7yC-4m29A:
undetectable		 1a7yA-4m29A:
5.43
1a7yC-4m29A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 THR A 189
PRO B 244
THR A 188
PRO B 227
 None
 1.24A 1a7yA-4pelA:
undetectable
1a7yC-4pelA:
undetectable		 1a7yA-4pelA:
4.51
1a7yC-4pelA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhz CRY23AA1
CRY37AA1

(Bacillus
thuringiensis;
Bacillus
thuringiensis) 		PF03318
(ETX_MTX2)
no annotation 		4 THR B  32
PRO B  34
THR A 247
PRO A 245
 None
 1.19A 1a7yA-4rhzB:
undetectable
1a7yC-4rhzB:
undetectable		 1a7yA-4rhzB:
8.74
1a7yC-4rhzB:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 THR A  34
PRO A  32
THR A  33
PRO A  54
 None
 1.21A 1a7yA-4rt6A:
undetectable
1a7yC-4rt6A:
undetectable		 1a7yA-4rt6A:
1.82
1a7yC-4rt6A:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i65 NONSTRUCTURAL
PROTEINS ORF1A

(Porcine
reproductive
and respiratory
syndrome virus) 		PF16749
(Arteri_nsp7a) 		4 THR A 132
PRO A 135
THR A 134
PRO A 137
 None
 1.00A 1a7yA-5i65A:
undetectable
1a7yC-5i65A:
undetectable		 1a7yA-5i65A:
12.33
1a7yC-5i65A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 THR A 240
PRO A 229
THR A 228
PRO A 231
 None
 1.31A 1a7yA-5ikpA:
undetectable
1a7yC-5ikpA:
undetectable		 1a7yA-5ikpA:
1.22
1a7yC-5ikpA:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 THR A 951
PRO A 908
THR A 952
PRO A 984
 None
 1.35A 1a7yA-5x7sA:
undetectable
1a7yC-5x7sA:
undetectable		 1a7yA-5x7sA:
1.72
1a7yC-5x7sA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		4 THR A 477
PRO A 216
THR A 215
PRO A 218
 None
 1.29A 1a7yA-5xhqA:
undetectable
1a7yC-5xhqA:
undetectable		 1a7yA-5xhqA:
1.83
1a7yC-5xhqA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9y THIAZOLE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 4 THR A  42
PRO A  68
THR A  67
PRO A  70
 None
 1.28A 1a7yA-5z9yA:
undetectable
1a7yC-5z9yA:
undetectable		 1a7yA-5z9yA:
undetectable
1a7yC-5z9yA:
undetectable